Dissertations / Theses on the topic 'Cognitive decline'
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Hogervorst, Eva. "Age-related cognitive decline and cognition enhancers." Maastricht : Maastricht : Neuropsych Publishers ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=6058.
Full textMcAulay, Vincent. "Cognitive decline during acute hypoglycaemia." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24922.
Full textDe, Marco Matteo. "Cognitive and physical stimulation, genetic risk and cognitive decline." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3379/.
Full textMiralbell, Blanch Júlia. "Biomarkers of cognitive decline and dementia." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/91068.
Full textEl terme deteriorament cognitiu (DC) es refereix al contínuum de canvis cognitius associats a l’envelliment sa i patològic. El diagnòstic precoç de les persones amb DC és clau, ja que els tractaments són més eficaços quan s’inicien als inicis de la malaltia. Els biomarcadors s’han proposat com a eines pel diagnòstic precoç del DC i la demència. Es consideren indicadors in vivo de la patologia i s’han plantejat com a possibles eines pel diagnòstic, pronòstic i seguiment del DC i la patologia subjacent. L’objectiu general de la present tesi era explorar els mecanismes patofisiològics subjacents al deteriorament cognitiu vascular (DCV) i la (MA). Per aquest motiu, vàrem mesurar diversos biomarcadors sanguinis i de LCR en persones sanes i en persones amb diagnòstic de deteriorament cognitiu i vàrem relacionar-los amb canvis de l’estructura cerebral i de la cognició. L’objectiu final era identificar possibles biomarcadors pel diagnòstic precoç d’aquestes malalties. Els estudis I i II s’emmarquen dins del projecte Barcelona-ASIA Neuropsicologia i tenien com a objectiu estudiar la relació entre biomarcadors en plasma de malaltia vascular cerebral (MVC) i canvis estructurals i cognitius. Els resultats obtinguts mostren que els biomarcadors d’inflamació i trombosi vascular es relacionen amb un perfil de deteriorament cognitiu vascular tant a nivell cognitiu com estructural. La lesió microvascular dels tractes de SB còrtico-subcorticals mediaria l’associació entre aquests mecanismes i la cognició. Els marcadors de disfunció endotelial es relacionen amb un perfil cognitiu diferent, que és característic tant de processos vasculars com neurodegeneratius. L’estudi III té com a objectiu valorar el possible ús dels biomarcadors de líquid cefaloraquidi pel diagnòstic de la MA. En concret, vàrem estudiar els perfils estructurals i cognitius en persones amb deteriorament cognitiu emprant punts de tall de líquid cefaloraquidi com a criteri d’agrupació. Els resultats mostren que pacients amb DC i amb nivells patològics de t-tau i p-tau al LCR (però no d’Aβ1-42) presenten un perfil cognitiu i estructural de MA. En conclusió, els resultats obtinguts en la present tesi suggereixen que, complementaris a l’observació clínica, els biomarcadors de LCR i plasma, així com els indicadors de morfologia cerebral podrien ser d’ús pel diagnòstic precoç del DCL i la demència.
Lu, Zhengdong. "Constrained clustering and cognitive decline detection /." Full text open access at:, 2008. http://content.ohsu.edu/u?/etd,650.
Full textMarston, Kieran John. "Preventing cognitive decline through resistance training." Thesis, Marston, Kieran John (2019) Preventing cognitive decline through resistance training. PhD thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/51337/.
Full textFortman, James Alexander. "Computer-Based Cognitive Training for Age-Related Cognitive Decline and Mild Cognitive Impairment." Antioch University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1353454752.
Full textSaxton, Judith. "Cognitive and functional decline in Alzheimer's disease." Thesis, University of Reading, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254512.
Full textMorrell, Lucy. "Informant reported cognitive decline in older adults." Thesis, Canterbury Christ Church University, 2017. http://create.canterbury.ac.uk/16424/.
Full textLi, Xiaoxia. "A Semiparametric Trajectory Model for Cognitive Decline." Diss., North Dakota State University, 2017. http://hdl.handle.net/10365/25922.
Full textNite, Leesa C. (Leesa Celeste). "Cognitive Decline in Chronic Pain Patients: A Neuropsychological Evaluation." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc331398/.
Full textMcGuinness, Bernadette. "Neuropsychological profiling and biomarkers of cognitive decline in mild cognitive impairment subjects." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602499.
Full textCadar, D. "The role of lifestyle behaviours on cognitive functioning and on cognitive decline." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1406203/.
Full textThompson, Juliann. "Sex Differences in Cognitive Decline in Mild Cognitive Impairment and Alzheimer's Disease." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6412.
Full textAndersson, Christin. "Predictors of cognitive decline in memory clinic patients /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-232-3/.
Full textJia, Xueli. "Nutrition, survival, and cognitive decline in older people." Thesis, University of Aberdeen, 2007. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=186836.
Full textLin, Ping-hsiu. "Functional change in older adults ‘at risk’ of dementia." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27495.
Full textSjölinder, Marie. "Age-related cognitive decline and navigation in electronic environments." Doctoral thesis, Stockholm University, Department of Psychology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1038.
Full textThe older population is increasing, as is life expectancy. Technical devices are becoming more widespread and used for many everyday tasks. Knowledge about new technology is important to remain as an active and independent part of the society. However, if an old user group should have equal access to this technology, new demands will be placed on the design of interfaces and devices. With respect to old users it is and will be important to develop technical devices and interfaces that take the age-related decline in physical and cognitive abilities into account. The aim of this work was to investigate to what extent the age-related cognitive decline affects performance on different computer-related tasks and the use of different interfaces. With respect to the use of computer interfaces, two studies were conducted. In the first study, the information was presented with a hierarchical structure. In the second study the information was presented as a 3D-environment, and it was also investigated how an overview map could support navigation. The third study examined the age-related cognitive decline in the use of a small mobile phone display with a hierarchical information structure. The results from the studies showed that the most pronounced age-related difference was found in the use of the 3D-environment. Within this environment, prior experience was found to have the largest impact on performance. Regarding the hierarchical information structures, prior experience seemed to have a larger impact on performance of easy tasks, while age and cognitive abilities had a larger impact on performance of more complex tasks. With respect to navigation aids, the overview map in the 3D-environment did not reduce the age-differences; however, it contributed to a better perceived orientation and reduced the feeling of being lost.
Dongen, Martinus Cornelis Johannes Maria van. "Efficacy of Ginkgo biloba in dementia and cognitive decline." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6864.
Full textSjölinder, Marie. "Age-related cognitive decline and navigation in electronic environments /." Stockholm : Department of Psychology, Stockholm University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1038.
Full textAmend, Diane Lisa. "Cognitive decline in depressed elderly with olfactory identification impairment." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186685.
Full textMesserotti, Benvenuti Simone. "Psychobiological mechanisms underlying cognitive decline in cardiac surgery patients." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422056.
Full textLe innovazioni tecnologiche conseguite nella seconda metà del XX secolo hanno ridotto le complicazioni maggiori e la mortalità nei pazienti sottoposti a cardiochirurgia. Nonostante gli evidenti benefici clinici nella pratica medica, un numero significativo di pazienti presenta disfunzioni neurologiche e/o psicologiche nel periodo postoperatorio che, a loro volta, sono responsabili per l’incremento della mortalità perioperatoria e della morbidità postoperatoria. Tali disfunzioni neurologiche e cognitive in seguito a cardiochirurgia sono il risultato di diversi fattori preoperatori e/o intraoperatori. Mentre le variabili demografiche, biomediche e psicologiche (tra cui ansia e depressione) rappresentano importati fattori preoperatori associati allo stato di salute postoperatorio, l’ipoperfusione cerebrale, l’embolizzazione e/o i processi neuroinfiammatori associati al bypass cardiopolmonare durante la chirurgia rappresentano fattori di rischio intraoperatori per le disfunzioni neurologiche e cognitive postoperatorie. Sebbene vi sia un sempre crescente interesse nello studio delle disfunzioni psicologiche in seguito a cardiochirurgia, i meccanismi psicobiologici sottostanti il declino cognitivo postoperatorio devono ancora essere indagati. Perciò, nella presente tesi sono descritti quattro studi che, per prima cosa, avevano lo scopo di indagare l’entità del declino cognitivo e della depressione in seguito a cardiochirurgia e, in secondo luogo, miravano ad identificare alcuni fattori di stampo psicobiologico coinvolti nel declino cognitivo e depressione postoperatori. L’Esperimento I mirava, come scopo principale, a fornire nuove evidenze circa la relazione, nel periodo preoperatorio, tra ansia, depressione, disfunzioni cognitive e punteggi di rischio biomedico (lo Stroke Index e l’European System for Cardiac Operative Risk Evaluation) in pazienti in attesa di intervento cardiochirurgico. I risultati del presente studio hanno indicato che, mentre entrambi i punteggi di rischio biomedico erano associati allo stato cognitivo preoperatorio dei pazienti cardiochirurgici, solo l’European System for Cardiac Operative Risk Evaluation teneva in considerazione anche i fattori di rischio associati all’ansia e depressione. Lo scopo principale degli Esperimenti II e III era indagare l’associazione fra fattori emodinamici cerebrali perioperatori e disfunzioni cognitive in seguito a cardiochirurgia. L’Esperimento II è stato disegnato per indagare se l’ipoperfusione cerebrale preoperatoria potesse essere un predittore di declino cognitivo postoperatorio nei pazienti sottoposti a cardiochirurgia, anche dopo aver controllato per i più comuni fattori di rischio demografici e biomedici. L’Esperimento II ha mostrato che l’incidenza del declino cognitivo si associava selettivamente all’ipoperfusione nell’arteria cerebrale media sinistra, mentre la velocità di flusso ematico nell’arteria cerebrale media destra non correlava con il declino cognitivo postoperatorio. L’ipoperfusione cerebrale sinistra, quindi, sembra rappresentare un fattore di rischio indipendente per il declino cognitivo in pazienti sottoposti a cardiochirurgia. L’Esperimento III è stato disegnato per determinare il ruolo dell’asimmetria e della natura della microembolizzazione intraoperatoria sul declino cognitivo postoperatorio in pazienti sottoposti a chirurgia valvolare. L’Esperimento III ha mostrato che la microembolizzazione intraoperatoria nell’arteria cerebrale media sinistra correlava significativamente sia con il declino cognitivo nell’immediato postoperatorio (alle dimissioni) che a distanza nel tempo (a 3 mesi dall’intervento chirurgico), mentre gli eventi embolici nell’arteria cerebrale media destra non erano associati né al declino cognitivo immediato né a distanza nel tempo. Inoltre, i microemboli solidi correlavano significativamente con il declino cognitivo immediato ma non al follow-up di 3 mesi. Al contrario, è stata riscontrata un’associazione significativa tra gli eventi microembolici gassosi ed il declino cognitivo immediato e a 3 mesi di distanza dall’intervento chirurgico. Dato il ruolo rilevante giocato dalla depressione come fattore di rischio per le disfunzioni cognitive postoperatorie, lo scopo principale dell’Esperimento IV è stato quello di indagare, nel periodo postoperatorio, se e come la depressione potesse influenzare l’attività elettroencefalografica durante un compito di imagery emozionale, il quale, a sua volta, implica sia un’elaborazione di tipo cognitivo che emozionale. Sebbene nessuna differenza tra i gruppi sia stata riscontrata nell’attività elettroencefalografica a riposo, rispetto ai controlli non depressi, si osservava nei pazienti depressi una ridotta attività theta frontale durante il compito di imagery emozionale. Inoltre, una ridotta ampiezza della theta frontale si associava selettivamente a disregolazione emozionale (ridotta capacità di reappraisal). Questi esperimenti, considerati nel loro insieme, forniscono una migliore e più approfondita comprensione dei meccanismi psicologici e fisiologici sottostanti il fenomeno del declino cognitivo e depressione postoperatori in pazienti cardiochirurgici. In conclusione, la presente tesi suggerisce la possibilità di includere sia una valutazione cognitiva e affettiva pre e postoperatoria che misure emodinamiche e/o elettroencefalografiche oggettive in grado di predire e/o facilitare il trattamento delle disfunzioni psicologiche postoperatorie nei pazienti sottoposti a cardiochirurgia
Xicota, Vila Laura 1987. "Biomarkers and cognitive function in Down syndrome : validation for phenotyping cognitive impairment." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/482222.
Full textEls assajos clínics que cerquen la millora del rendiment cognitiu tenen la necessitat de disposar de biomarcadors que reflecteixin els processos que tenen lloc en el cervell. En la síndrome de Down aquesta informació és crucial per a entendre la progressió del declini cognitiu o per a avaluar els efectes beneficiosos d’un tractament però encara hi ha pocs biomarcadors disponibles per a aquesta afectació. Hem avaluat l’associació entre biomarcadors (bioquímics, genètics), funcions executives i declini cognitiu, en el context d’un assaig clínic, tenint en compte factors extrínsecs (educació, dieta) que poden afectar la interpretació dels resultats. Els nostres demostren que un perfil lipídic alterat o unes concentracions incrementades d’homocisteïna en plasma estan associats a pitjors funcions executives. També observem una associació entre concentracions incrementades de pèptids amiloides i signes primerencs de demència. També he optimitzat una nova tècnica de cultiu tissular i cel·lular per a obtenir precursors neuronals de l’epiteli olfactiu per a l’estudi de biomarcadors. Els resultats d’aquest estudi podrien proporcionar noves eines per a avaluar l’eficàcia de tractament i el risc de declini cognitiu en el context d’assaigs clínics en la síndrome de Down.
Clarnette, Roger M. "Predictors of cognitive decline in those with subjective memory complaint." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0245.
Full textFarias, Alyne Matos Napoleão. "Estimulação cognitiva em idosos sedentários com transtorno cognitivo leve." Universidade Católica de Brasília, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2459.
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In Brazil the number of elderly people is increasing and this transformation in the age structure is taking place without an improvement of the living conditions. With increased life expectancy there is a greater probability of chronic and degenerative diseases, such as Mild Cognitive Disorder (MCD). The use of cognitive stimuli through cognitive stimulation therapies (CST) causes them to regress and / or interfere with advancement. The objective was to analyze changes in cognitive profile, with emphasis on memory, before and after the execution of cognitive stimulation workshops, as well as to identify socioeconomic characteristics of sedentary elderly people who attend the Mixed Health Unit of Taguatinga, Federal District (UMS-DF). It was a descriptive experimental quantitative study, with elderly (≥60 years), diagnosed with MCD. The composite sample of 9 elderly of the OEC in the experimental group (G1) and 10 elderly did not undergo intervention in the control group (G2). The data collection was done by structured interview, application in the first and last meeting of the mini mental state examination, verbal fluency, clock, memory of figures and list of words. The CST offered to the G1, stimulation techniques were used, for one hour, weekly, in 10 meetings. In G2, daily life activities were reported for the same period, without cognitive stimulation. The descriptive data were evaluated by means of descriptive measures: means, standard deviations, median, absolute and relative frequency, with p <= 0,05. The chi-square test and t-test were applied using the SPSS 20.0 program and the R. software. Results showed mean age of 75 ± years, 84.2% female, 89.5% retired and 89.5% widowed. 17 elderly (89.5%) reported better memory a year ago. After CST, 8 (88.9%) elderly of the G1 considered their current memory as good. Although the G1 elderly had higher scores in all tests after the CST, the difference between the tests was not significant (p = 1.0). No significant differences were found in the Miniexame of the Mental State (p = 0.436). The test of the clock design evidenced the low level of schooling. G1 (p> 1) and G2 (p = 0.621), the tests were not statistically significant, affirming no or almost no change in the cognitive profile. In the tests of verbal fluency (p = 0.367), word memory and figures (p = 0.351), G2 showed no recovery in recall, despite reporting an increase in group sociability. It was concluded that although the CST do not have significant results, they have a visible effect on social integration, exchange of experiences and personal empowerment. This method can help nursing to design more effective methods and implementations for the treatment and rehabilitation of not only elderly people with MCD, but with different cognitive conditions. Perhaps longer-term studies can improve such outcomes and encompass the positive aspects of physical activity in the cognitive area.
No Brasil, é crescente o número de idosos e essa transformação na estrutura etária dá-se sem que haja um melhoramento das condições de vida. Com o aumento da expectativa de vida, há maior probabilidade de doenças crônicas e degenerativas, como o Transtorno Cognitivo Leve (TCL). A utilização de estímulos cognitivos, através de oficinas de estimulação cognitiva (OEC), causa seu retrocesso e/ou interfere no avanço. O objetivo foi analisar modificações no perfil cognitivo, com ênfase na memória, antes e após a execução das oficinas de estimulação cognitiva, assim como identificar características socioeconômicas de idosos sedentários que frequentam a Unidade Mista de Saúde de Taguatinga do Distrito Federal (UMST-DF). Foi um estudo quantitativo experimental descritivo, com idosos (≥60 anos), diagnosticados com TCL. A amostra composta de nove idosos das OEC no grupo experimental (G1) e dez idosos que não sofreram intervenção no grupo controle (G2). A coleta de dados foi feita por entrevista estruturada, aplicação no primeiro e último encontro do Miniexame do Estado Mental (MEEM), fluência verbal, relógio, memória de figuras e lista de palavras. As OEC oferecidas ao G1 utilizaram técnicas de estimulação, por uma hora, semanalmente, em dez encontros. No G2, foram feitos relatos das atividades da vida diária, pelo mesmo período, sem estimulação cognitiva. Os dados descritivos foram avaliados pelas medidas descritivas: médias, desvios padrões, mediana, frequência absoluta e relativa, com p<=0,05. Foram aplicados teste de qui-quadrado e teste t pelo programa SPSS 20.0 e software R. Resultados mostraram idade média de 75± anos, 84,2% feminino, 89,5% aposentados e 89,5% viúvos. 17 idosos (89,5%) relataram memória melhor há um ano. Após as OEC, oito (88,9%) idosos do G1 consideraram sua memória atual como boa. Apesar dos idosos do G1 terem pontuações maiores em todos os testes após as OEC, a diferença entre os testes não foram significativas (p= 1,0). No MEEM não surgiu diferença significativa (p=0,436). O teste do desenho do relógio evidenciou o baixo nível de escolaridade: G1 (p>1) e G2 (p= 0,621); os testes não foram significativos, afirmando nenhuma ou quase nenhuma mudança no perfil cognitivo. Nos testes de fluência verbal (p=0,367), de memória de palavras e o de figuras (p=,0,351), o G2 não mostrou recuperação na evocação da memória, apesar de relatar aumento na sociabilidade em grupo. Concluiu-se que, apesar das OEC não terem resultados estatisticamente significativos, possuem efeito visível na integração social, troca de experiências e empoderamento pessoal. Esse método pode auxiliar a enfermagem a traçar métodos e implementações mais eficazes para o tratamento e reabilitação, não só pessoas idosas com TCL, mas com diversas condições cognitivas. Talvez estudos com prazos maiores possam aprimorar tais resultados e abranger os aspectos positivos das atividades físicas na área cognitiva.
Hemmy, Laura Sue. "Educational attainment and rate of cognitive decline in Alzheimer's disease." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1189.
Full textAlexander, Jane. "Cognitive decline and Alzheimer's disease in persons with Down syndrome." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21546.pdf.
Full textSaxby, Brian Kent. "Blood pressure, antihypertensive treatment and cognitive decline in older adults." Thesis, University of Newcastle Upon Tyne, 2009. http://hdl.handle.net/10443/1500.
Full textLittlejohn, Jenna. "Central and peripheral auditory changes and cognitive decline in ageing." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/21719/.
Full textRöhr, Susanne, Arno Villringer, Matthias C. Angermeyer, Tobias Luck, and Steffi G. Riedel-Heller. "Outcomes of stable and unstable patterns of subjective cognitive decline." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215683.
Full textMorris, Rose Elizabeth. "Gait as a predictor for cognitive decline in Parkinson's disease." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3725.
Full textEuser, S. M. "Determinants of cognitive decline and dementia in the very old." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/14187.
Full textMilane, Russell Edward. "Alternative Augmentative Care Planning in Patients with a Cognitive Decline." Thesis, Grand Canyon University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10976265.
Full textNurse dissatisfaction occurs when the quality in communication of persons affected by a cognitive decline is impacted during the transmission process. It is necessary to understand the nurse’s perception of this situation and how alternative augmentative communication (AAC) patient-centered care intervention (PCCI) care planning provides the most advantageous strategy. The purpose of this Direct Practice Improvement (DPI) project is to understand how ten nurses perceived their level of dissatisfaction while communicating with patients with a cognitive decline before and after implementation of an AAC PCCI care plan intervention at a Long Term Care Home (LTCH) in Southeast Iowa. This project demonstrated the importance of implementing AAC PCCI care planning as a means to decrease nurse dissatisfaction when caring for individuals with cognitive decline. Their perception was measured prior and following implementation of the care plan. The project utilized Watson’s theory of human caring to support the perceptual and qualitative nature of this project. A case study framework using qualitative open-ended questions solicited the nurse’s personal perceptual view and experiences in answering the clinical questions. The data results of (N=10) nurse’s narratives were analyzed. A confidence interval of 95% provided statistical significance supporting AAC PCCI care planning implementation as a means to improve nurse satisfaction. The measurable practice outcome of this project’s AAC PCCI care planning implementation is effective in decreasing nurse dissatisfaction. A future recommendation is to provide a quantitative approach as a means to provide additional reliability.
JANJUA, ZAFFAR HAIDER. "SENSOR-BASED BEHAVIORAL MONITORING FOR EARLY DETECTION OF COGNITIVE DECLINE." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/391782.
Full textChan, Kelly J. "The Bilingual Advantage in Cognitive Control and its Consequences for Cognitive Decline in Natural Aging." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/cmc_theses/1133.
Full textBauer, Corinna Mae. "Multimodal analysis in normal aging, mild cognitive impairment, and Alzheimer's disease: group differentiation, baseline cognition, and prediction of future cognitive decline." Thesis, Boston University, 2013. https://hdl.handle.net/2144/10937.
Full textAlzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that makes it difficult to distinguish from normal aging. It begins with an impairment of memory that develops into amnestic mild cognitive impairment (aMCI) and later to dementia as deficits become apparent in other cognitive domains. Effective biomarkers that differentiate normal aging, MCI, and AD and predict future cognitive decline are needed. Potential biomarkers have been studied in isolation, but their impact when combined is not understood. The goal of this project is to determine the optimal combination of CSF biomarkers, MRI morphometry, FDG PET metabolism, and neuropsychological test scores to differentiate between normal aging subjects and those with MCI and AD. This study addresses: 1) the optimal normalization region and partial volume correction method to quantify FDG PET analysis, 2) the effects of adjusting MRI-based cortical thickness measures for differences in gray/white matter tissue contrast in normal aging and disease, 3) whether multimodal multivariate stepwise logistic regression models can predict group membership, and 4) whether multimodal multivariate stepwise linear regression models can determine which imaging and CSF biomarker variables best predict future cognitive decline. The results indicate that normalizing FDG PET to the cerebellum along with using a gray matter mask for partial volume correction provides optimal prediction. In contrast, age-associated changes in gray/white matter intensity ratio did not differentiate between the groups and only slightly improved the efficacy of cortical thickness as a biomarker. MRI morphometry of the gray matter and neuropsychological test scores were better able to discriminate between the groups than FDG PET or CSF biomarker concentrations. Combining all modalities significantly improved the index of discrimination, especially at the earliest stages of the disease. MRI gray matter morphometry variables were more highly associated with baseline cognitive function and best predicted future cognitive decline compared to other variables. Overall these findings demonstrate that a multimodal approach using MRI morphometry, FDG PET metabolism, neuropsychological test scores, and CSF biomarkers provides significantly better discrimination than any modality alone. Hence, the variables important for discriminating between the groups may be candidates for biomarkers in human clinical interventional trials.
Quadros, Junior Antonio Carlos de. "Dança de salão, funções executivas e memória em idosos institucionalizados /." Rio Claro : [s.n.], 2008. http://hdl.handle.net/11449/87426.
Full textAbstract: Aging causes physical and/or cognitive decline. Moreover, some consequences of older adult's institutionalization seem to exert a negative influence on their physical and cognitive spheres, which are generally are impaired. Anyhow, aerobic exercise can benefit both spheres. So, this research is divided into Study #1 (transversal) and Study #2 (longitudinal). OBJECTIVE: accomplish the profile of physical activity level, basic functional independence, executive functions, memory and general cognitive state of older adults living in the long-care homes at Rio Claro-SP (Study #1), and to analyze the possible effects of a Ballroom Dancing program in those variables (Study #2). MATERIAL AND METHODS: the sample selected in the framework of the Study#1 was randomized and achieved 89,8% of institutionalized population. With regard to Study #2, the sample included 14 older adults in the control group and 13 older adults in the training group. The training consisted by three sessions of Ballroom Dancing a week, during six months. The same battery of tests and questionnaires was applied to both studies. The data were analyzed with p<0,05. Along the Study #1, the mean and the standard-desviation e quarters were calculated, as well as the Pearson correlation coefficient concerning the physical activity level and the basic functional independence with other variables. Along the Study #2, ANOVA two-way, three-way e fourway was used, according with the test, in addition to the Pearson correlation coefficient. RESULTS: in both studies, older adult's engagement was lower than expected. Study #1 shows that: age=75.3 years old; Mini Exam of Mental State=11.5 points; Geriatric Depression Scale=12.8 points; Modified Baecke 100 Questionnaire for Older Adults=1.0 point, and Katz Scale of Basic Functional Independence=4.5 points, in addition... (Complete abstract click electronic access below)
Orientador: Sebastião Gobbi
Coorientador: Ruth Ferreira Santos
Banca: Hanna Karen Moreira Antunes
Banca: Cátia Mary Volp
Mestre
Camire, Walter P. "Predictors and Classification Systems of Cognitive Decline or Impairment During Aging." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/CamireWP2005.pdf.
Full textRafnsson, Snorri Björn. "Cardiovascular diseases, risk factors and cognitive decline in the general population." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/30665.
Full textGriffin, Sarah C. "LONELINESS, CYNICAL HOSTILITY, AND COGNITIVE DECLINE IN AMERICANS ABOVE AGE 50." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4192.
Full textRouanet, Anais. "Study of dementia and cognitive decline accounting for selection by death." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0243/document.
Full textThe purpose of this work is to develop statistical tools to study the general or the prediagnosis cognitive decline, while accounting for the selection by death and interval censoring. In cohort studies, the time-to-dementia-onset is interval-censored as the dementia status is assessed intermittently. This issue can lead to an under-estimation of the risk of dementia, due to the competing risk of death: subjects with dementia are at high risk to die and can thus die prior to the diagnosis visit. First, we propose a joint latent class illness-death model for longitudinal data correlated to an interval-censored time-to-event, competing with the time-to-death. This model is applied on the Paquid cohort to identify profiles of pre-dementia cognitive declines associated with different risks of dementia and death. Using this methodology, we compare dynamic prognostic models for dementia based on repeated measures of cognitive markers, accounting for interval censoring. Secondly, we conduct a simulation study to clarify the interpretation of maximum likelihood estimators of joint and mixed models as well as GEE estimators, frequently used to handle incomplete longitudinal data truncated by death. Maximum likelihood estimators target the individual change among the subjects currently alive. GEE estimators with independent working correlation matrix, weighted by the inverse probability to be observed given that the subject is alive, target the population-averaged change among the dynamic population of survivors. These results justify the use of joint models in dementia studies, which are promising statistical tools to better understand the natural history of dementia
Runge, Shannon K. "Genetic Moderators of Cognitive Decline in the Health and Retirement Study." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6374.
Full textHamilton, Joanne M. "Cognitive, motor, and behavioral correlates of functional decline in Huntington's disease /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9975028.
Full textPorter, Tenielle L. S. "Genetic determinants of rates of cognitive decline in preclinical Alzheimer’s Disease." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2018. https://ro.ecu.edu.au/theses/2114.
Full textFabbri, Elisa <1985>. "NAFLD and cognitive decline in older adults: a longitudinal cohort study." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8791/1/Fabbri_Elisa_tesi.pdf.
Full textMarioni, Riccardo Emilio. "Inflammation and cognition : the association between biomarker levels, their genetic determinants, and age-related cognitive decline." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4436.
Full textCastiglione, Alessandro. "Aging, cognitive decline and hearing loss: outcomes of auditory rehabilitation in older adults." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424842.
Full textIntroduzione. Il ripristino di una funzione neurosensoriale negli anziani può consentire un significativo miglioramento del loro stato cognitivo. Anche se condizioni cliniche specifiche possono compromettere la gestione e ridurre drasticamente il raggiungimento di risultati accettabili, la riabilitazione uditiva con impianti cocleari o apparecchi acustici resta ad oggi uno dei mezzi più efficaci. I progressi della ricerca e della tecnologia suggeriscono un "adattamento" funzionale nei processi centrali che potrebbe influenzare le altre attività connesse o meno strettamente correlate con la funzione uditiva, come la memoria di lavoro, processi frontale e pre-frontali, orientamento, calcolo, logica e funzioni esecutive. Dal momento che il legame tra la perdita dell'udito e il declino cognitivo è stato chiarito, la comunità scientifica è ora alla ricerca dell’evidenza scientifica mancante dell’efficacia della riabilitazione uditiva nel ridurre o contrastare il declino cognitivo. Materiali e Metodi. Soggetti con deficit uditivo con più di 65 anni di età, affetti da sordità lieve-profonda sono stati arruolati in questo studio; la valutazione audiologica completa e la valutazione dello stato cognitivo sono stati effettuati al fine di definire punteggi personali per il confronto longitudinale dopo la riabilitazione uditiva. Un gruppo di controllo di 20 soggetti è stato creato a fini statistici e realizzato con soggetti normo-udenti senza declino cognitive, omogenei per età e condizioni cliniche. Diversi sottogruppi sono stati creati per ridurre l'eterogeneità in termini di entità della perdita di udito, di durata della deprivazione neurosensoriale, del tipo di riabilitazione e di training uditivo. Un follow up di 6-12 mesi è stata effettuato, ove possibile per pazienti selezionati. Risultati. Ad oggi, 77 soggetti sono stati inclusi nel presente studio e divisi in 5 gruppi diversi in base ai tipi e gradi di perdita dell'udito. Non tutti i soggetti sono riusciti a completare la batteria di test previsti, tuttavia le analisi statistiche con t-student e fisher test e chi quadro, quando possibile applicarli, hanno mostrato una differenza significativa nei punteggi di depressione e stato cognitivo, prima e dopo la riabilitazione uditiva. Non sono risultate differenze significative tra il gruppo di controllo ed i pazienti con buon esito della riabilitazione. Discussione. La riabilitazione uditiva presenta una significativa efficacia anche tra gli adulti più anziani con diversi gradi di perdita di udito e miglioramenti positivi sono rilevabili in termini di isolamento sociale, depressione e le prestazioni cognitive. Nella ricerca futura, sarà di fondamentale importanza svelare come le capacità neurosensoriali siano legate al funzionamento cognitivo nell'invecchiamento. Oggi, l’approccio medico convenzionale spesso non è sufficiente per valutare le persone più anziane con comorbidità. In definitiva, un approccio multidisciplinare rimane ancora l'opzione migliore, ed il geriatra dovrebbe includere specifiche indagini neurosensoriali per gestire i pazienti anziani che sono generalmente a rischio di declino cognitivo e perdita di udito.
Donnelly, Karen J. "The development of an instrument for assessing cognitive ability and screening for the cognitive decline associated with dementia in people with moderate to profound intellectual disability." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/83727/4/Karen_Donnelly_Thesis.pdf.
Full textEdwards, Carolyn Anne. "The role of the frontal cortex in normal age-related memory performance." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389161.
Full textLittbrand, Rebecka. "WEAVING IN WOOD : An architectural strategy in Umeå that strive to decrease loneliness and include elderly with physical and cognitive impairments." Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173960.
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