Journal articles on the topic 'Cognition in old age – Longitudinal studies'
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1
Sánchez-Izquierdo, Macarena, and Rocío Fernández-Ballesteros. "Cognition in Healthy Aging." International Journal of Environmental Research and Public Health 18, no. 3 (January 22, 2021): 962. http://dx.doi.org/10.3390/ijerph18030962.
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The study of cognitive change across a life span, both in pathological and healthy samples, has been heavily influenced by developments in cognitive psychology as a theoretical paradigm, neuropsychology and other bio-medical fields; this alongside the increase in new longitudinal and cohort designs, complemented in the last decades by the evaluation of experimental interventions. Here, a review of aging databases was conducted, looking for the most relevant studies carried out on cognitive functioning in healthy older adults. The aim was to review not only longitudinal, cross-sectional or cohort studies, but also by intervention program evaluations. The most important studies, searching for long-term patterns of stability and change of cognitive measures across a life span and in old age, have shown a great range of inter-individual variability in cognitive functioning changes attributed to age. Furthermore, intellectual functioning in healthy individuals seems to decline rather late in life, if ever, as shown in longitudinal studies where age-related decline of cognitive functioning occurs later in life than indicated by cross-sectional studies. The longitudinal evidence and experimental trials have shown the benefits of aerobic physical exercise and an intellectually engaged lifestyle, suggesting that bio-psycho-socioenvironmental factors concurrently with age predict or determine both positive or negative change or stability in cognition in later life.
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Ahmed, Tamer, and Helen-Maria Vasiliadis. "Global Cognition Modified the Longitudinal Relationship Between Anemia and Depression in Old Age: The IMIAS Study." Innovation in Aging 4, Supplement_1 (December 1, 2020): 168–69. http://dx.doi.org/10.1093/geroni/igaa057.546.
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Abstract Background: We examined the longitudinal relationships between hemoglobin concentrations or the severity of anemia and depression and whether baseline cognitive function modifies these longitudinal relationships over 4 years of follow-up. Methods: A total of 1608 community-dwelling older adults from the International Mobility in Aging Study (IMIAS) aged 65 to 74 years were recruited in Natal (Brazil), Manizales (Colombia), Kingston (Ontario, Canada), and Saint-Hyacinthe (Quebec, Canada). The study outcome was depression, defined by a score of 16 or over in the Center for Epidemiologic Studies Depression Scale (CES-D). Longitudinal associations over four years follow-up were examined using generalized estimating equations. Models reported were either unadjusted and adjusted for research sites, alcohol drinking status, body mass index, chronic conditions, activities of daily life disabilities, and polypharmacy. Results: Longuitinal relationships suggested an evidence of multiplicative interaction by baseline global cognition in which 1g/dL increase in hemoglobin concentrations there was a significant reduction in the risk of depression with a stronger effect among participants with good cognitive function (Odds Ratio (OR)=0.85, 95% CI: 0.78-0.92) compared to those with poor cognition (OR=0.89, 95% CI: 0.80-0.97). Anemia and poor cognition at baseline were associated with an increased risk of depression over 4 years of follow-up (OR=5.80, 95% CI: 1.84-18.23). Global cognition was an effect modifier of the longitudinal association between the severity of anemia and depression. Conclusion: In international samples of older adults, hemoglobin concentrations, as well as the severity of anemia, were independent risk factors for depression and these associations differed by global cognitive function.
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Ahmed, Tamer, and Helen-Maria Vasiliadis. "331 - Global cognition modified the relationship between Anemia and Depression in old age: longitudinal analysis from The IMIAS Study." International Psychogeriatrics 32, S1 (October 2020): 90. http://dx.doi.org/10.1017/s1041610220002318.
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Running head:role of global cognition in the association between Anemia and depression.Background:We examined the longitudinal relationships between hemoglobin concentrations or Anemia and depression and whether baseline cognitive function modifies these longitudinal relationships over 4 years of follow-up.Methods:A total of 1608 community-dwelling older adults from the International Mobility in Aging Study (IMIAS) aged 65 to 74 years were recruited in Natal (Brazil), Manizales (Colombia), Kingston (Ontario, Canada), and Saint-Hyacinthe (Quebec, Canada). The study outcome was depression, defined by a score of 16 or over in the Center for Epidemiologic Studies Depression Scale (CES-D). Longitudinal associations over four years follow-up were examined using generalized estimating equations. Models reported were either unadjusted and adjusted for research sites, alcohol drinking status, body mass index, chronic conditions, activities of daily life disabilities, and polypharmacy.Results:Longuitinal relationships suggested an evidence of multiplicative interaction by baseline global cognition in which 1g/dL increase in hemoglobin concentrations there was a significant reduction in the risk of depression with a stronger effect among participants with good cognitive function (Odds Ratio (OR)=0.85, 95% CI: 0.78-0.92) compared to those with poor cognition (OR=0.89, 95% CI: 0.80-0.97). Anemia and poor cognition at baseline were associated with an increased risk of depression over four years of follow-up (OR=5.80, 95% CI: 1.84-18.23). Global cognition was also an effect modifier of the longitudinal association between the severity of Anemia and depression.Conclusion:In international samples of older adults, hemoglobin concentrations, as well as the severity of Anemia, were independent risk factors for depression, and these associations differed by global cognitive function.
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Schilling, Oliver K. "ALCOHOL CONSUMPTION AND MEMORY: A LONGITUDINAL ANALYSIS OF RECIPROCAL IMPACTS ACROSS OLD AGE." Innovation in Aging 3, Supplement_1 (November 2019): S651. http://dx.doi.org/10.1093/geroni/igz038.2416.
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Abstract Research on the association of alcohol consumption with cognitive aging revealed mixed evidence: Whereas a u-shaped relationship has been found in many studies, suggesting that low to moderate alcohol consumption predicts more favorable cognitive outcomes than abstinence, other findings suggest that alcohol is a more linearly related risk factor for cognitive decline. These inconsistencies may partly be due to methodological variation in the statistical modeling of intraindividual changes in both, alcohol consumption and cognition across old age. The present study analyzed longitudinal change in and the mutual effects between alcohol consumption habits and verbal episodic memory (word list recall), using vector autoregressive (VAR) mixed models with nonlinear cross-lagged effects. Data from the English Longitudinal Study of Ageing was examined, including N=13388 aged 50+ (M=67.6, SD=9.25; 54.7% female), assessed at up to eight occasions with two-year follow-up intervals (2002/3–2016/17). The self-reported one-year frequency of alcohol drinking days (ADD) served as indicator of alcohol consumption. Basically, ADD predicted follow-up memory performance in a reverse u-shaped fashion, indicating best memory performance after moderate ADD, compared with both ends of the ADD continuum (i.e., drinking never vs. every day). Considering moderators, most notably age did not interact with cross-lagged effects, suggesting that those observed across an older age-range were not more (or less) vulnerable to effects of alcohol consumption on memory performance. Thus, this study adds further support for non-detrimental, if not beneficial, effects of moderate alcohol consumption on cognitive aging – regarding in particular age-related loss of episodic memory.
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Zhang, Li, Jiao Yang, Zhangyi Liao, Xiaomeng Zhao, Xuefeng Hu, Wenli Zhu, and Zhaofeng Zhang. "Association between Diabetes and Cognitive Function among People over 45 Years Old in China: A Cross-Sectional Study." International Journal of Environmental Research and Public Health 16, no. 7 (April 11, 2019): 1294. http://dx.doi.org/10.3390/ijerph16071294.
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Objectives: The aim of this study is to identify the relationship between diabetes status including characteristics of diabetes and cognition among the middle-aged and elderly population (≥45 years) in China. Methods: A sample of 8535 people who participated in the China Health and Retirement Longitudinal Study (CHARLS) from June 2011 to March 2012 was analyzed. Two cognitive domains including episodic memory and executive function were measured through questionnaires. People were classified into four groups: no diabetes, controlled diabetes, untreated diabetes, treated but uncontrolled diabetes. Weighted multiple regression model was conducted to explore the association between diabetes and cognition in full sample as well as three different age groups (45–59, 60–74, ≥75). Adjustments were made for demographics and cardiovascular risk factors. Results: After adjusting several covariates, untreated diabetes (β = −0.192, p < 0.05) was significantly associated with episodic memory. In the age group of 45–69 years, untreated diabetes (β = −0.471, p < 0.05) and HbA1c level (β = −0.074, p < 0.05) were significantly associated with episodic memory. When adjusting for cardiovascular risk factors, all correlations were non-significant. Conclusion: The cross-sectional study suggests that untreated diabetes and HbA1c are the potential risk factor for cognitive impairment, and these associations are more significant in the age group of 45–59 years old. Cardiovascular factors are important mediating factors in the pathway between diabetes and cognitive impairment. More longitudinal studies are needed to confirm these associations.
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Ikeuchi, Tomoko, Satoshi Seino, Yu Taniguchi, Miki Narita, Takumi Abe, Hidenori Amano, Akihiko Kitamura, and Shoji Shinkai. "INFLUENCING FACTORS OF SUBJECTIVE AGE: FINDINGS FROM THE KUSATSU LONGITUDINAL STUDY ON AGING AND HEALTH." Innovation in Aging 3, Supplement_1 (November 2019): S695—S696. http://dx.doi.org/10.1093/geroni/igz038.2561.
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Abstract Background: Subjective age (SA) has been found to be a biopsychosocial marker of aging, yet little is known about factors that influence SA development. This study examined factors influencing SA using longitudinal data of community-dwelling older Japanese. Methods: Data drawn from the Kusatsu Longitudinal Study were collected during annual health check-ups in 2017 and 2018 from participants (aged 65-95) who completed all the measurement items used for this analysis (N=981). SA was indexed by asking participants to specify in years how old they felt. Proportional discrepancy scores ((subjective age - chronological age)/chronological age ×100) were calculated to indicate younger or older SAs and used as a dependent variable. As influencing factors of SA, chronological age, sex, years of schooling, history of smoking, cognitive function (using MMSE scores, range 14-30 at baseline), depressive symptoms, physical function (gait speed), and social function (employment status) were examined. Analyses were performed with random-effects GLS regression models. Results: Significant partial regression coefficients were found for cognitive function (0.48%, CI: 0.18, 0.79), years of schooling (-0.42%, CI: -0.69, -0.15), depressive symptoms (0.32%, CI: 0.11, 0.53), and chronological age (-0.18%, CI: -0.30, -0.68). Implications: This study found that older age and longer years of schooling were associated with younger SA, while better cognition and depressive symptoms were linked to older SA. Better cognition being associated with older SA was inconsistent with existing studies. This may be due in part to the association of better cognition and the level of satisfaction influenced by awareness of age-related physical/social changes.
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Zeng, Yue, and Yu-Chih Chen. "Grandparenting and Health in Later Life: Intensity and Age, Gender, and Urbanicity Variations." Innovation in Aging 4, Supplement_1 (December 1, 2020): 26. http://dx.doi.org/10.1093/geroni/igaa057.084.
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Abstract Grandparents play increasingly indispensable roles in providing family care. Although prior cross-sectional studies have shown a positive link between grandparenting and health, we know little about the optimal engagement level of grandparenting, its longitudinal implications, and variations on health outcomes. Guided by the role theory and social model of health promotion, we used propensity score analysis and multilevel analysis with three biennial waves of China Health and Retirement Longitudinal Study (2011-2015) to examine the longitudinal impacts of grandparenting intensity (no, low-, moderate-, and high-intensity) on health (mobility limitations, depressive symptoms, cognition, and self-rated health) among 4,925 older adults aged 45 and older, and how these impacts vary by age (45-59/60+), gender (male/female), and urbanicity (urban/rural). Controlling for the baseline sociodemographics (e.g., education and income), health limitations (e.g., ADLs and IADLs), and health behaviors (e.g., drinking and smoking), our results showed that, compared to no grandparenting, grandparenting provided at a moderate level was associated with fewer mobility limitations, lower depressive symptoms, and better cognition. Furthermore, grandparenting had a positive impact on physical, mental and cognitive health for 60+ older adults but not for the young-old. Both older males and females showed better physical health if they provided care at a low level, but older females showed better self-rated health. Older adults in the rural area showed better physical health; for the urban area older adults, better cognition. Findings suggest that policies aimed at supporting grandparents should consider the optimal threshold and variations by age, gender, and urbanicity.
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Irace, Alexandria, Nicole Armstrong, Jennifer Deal, Alexander Chern, Luigi Ferrucci, Frank Lin, Susan Resnick, and Justin Golub. "A Longitudinal Analysis of the Association Between Subclinical Hearing Loss and Cognition." Innovation in Aging 4, Supplement_1 (December 1, 2020): 895–96. http://dx.doi.org/10.1093/geroni/igaa057.3301.
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Abstract Several studies have demonstrated that age-related hearing loss (defined as >25 dB pure tone average [PTA]) is longitudinally associated with worse cognition. We aimed to investigate whether subclinical hearing loss (SCHL), or imperfect hearing traditionally categorized as normal (PTA ≤25 dB), may be similarly linked to cognitive decline. Subjects included cognitively normal adults ≥50 years old in the Baltimore Longitudinal Study of Aging with PTA ≤25 dB measured between January 1991 - September 1994 who had repeated cognitive assessments from January 1991 - November 2019 (n=263). The exposure was hearing based on the better ear PTA. The outcomes were standardized test scores in the following domains: learning/memory, mental status, executive function, visuospatial ability, and language. Multivariable linear-mixed effects models with random intercepts and slopes and unstructured variance-covariance structure were used to model the association between hearing and change in cognition over time, adjusting for baseline age, sex, years of education, and race. Mean age was 68.3 years (standard deviation [SD]=8.9) and follow-up ranged from 0-27.7 years (mean=12.5, SD=7.9). A 10-dB worsening in hearing was longitudinally associated with an annual decline of 0.016 SDs (95% confidence interval [CI]: 0.0002, 0.033) in California Verbal Learning Test (CVLT) short-delayed recall, 0.019 SDs (95% CI: 0.002, 0.036) in CVLT long-delayed recall, and 0.017 SDs (95% CI: 0.006, 0.028) in letter fluency after covariate adjustment. Poorer hearing among those with SCHL was associated with steeper declines in memory and verbal fluency scores. This relationship may begin at earlier levels of hearing loss than previously recognized.
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Hertzog, Christopher, Arthur F. Kramer, Robert S. Wilson, and Ulman Lindenberger. "Enrichment Effects on Adult Cognitive Development." Psychological Science in the Public Interest 9, no. 1 (October 2008): 1–65. http://dx.doi.org/10.1111/j.1539-6053.2009.01034.x.
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In this monograph, we ask whether various kinds of intellectual, physical, and social activities produce cognitive enrichment effects—that is, whether they improve cognitive performance at different points of the adult life span, with a particular emphasis on old age. We begin with a theoretical framework that emphasizes the potential of behavior to influence levels of cognitive functioning. According to this framework, the undeniable presence of age-related decline in cognition does not invalidate the view that behavior can enhance cognitive functioning. Instead, the course of normal aging shapes a zone of possible functioning, which reflects person-specific endowments and age-related constraints. Individuals influence whether they function in the higher or lower ranges of this zone by engaging in or refraining from beneficial intellectual, physical, and social activities. From this point of view, the potential for positive change, or plasticity, is maintained in adult cognition. It is an argument that is supported by newer research in neuroscience showing neural plasticity in various aspects of central nervous system functioning, neurochemistry, and architecture. This view of human potential contrasts with static conceptions of cognition in old age, according to which decline in abilities is fixed and individuals cannot slow its course. Furthermore, any understanding of cognition as it occurs in everyday life must make a distinction between basic cognitive mechanisms and skills (such as working-memory capacity) and the functional use of cognition to achieve goals in specific situations. In practice, knowledge and expertise are critical for effective functioning, and the available evidence suggests that older adults effectively employ specific knowledge and expertise and can gain new knowledge when it is required. We conclude that, on balance, the available evidence favors the hypothesis that maintaining an intellectually engaged and physically active lifestyle promotes successful cognitive aging. First, cognitive-training studies have demonstrated that older adults can improve cognitive functioning when provided with intensive training in strategies that promote thinking and remembering. The early training literature suggested little transfer of function from specifically trained skills to new cognitive tasks; learning was highly specific to the cognitive processes targeted by training. Recently, however, a new generation of studies suggests that providing structured experience in situations demanding executive coordination of skills—such as complex video games, task-switching paradigms, and divided attention tasks—train strategic control over cognition that does show transfer to different task environments. These studies suggest that there is considerable reserve potential in older adults' cognition that can be enhanced through training. Second, a considerable number of studies indicate that maintaining a lifestyle that is intellectually stimulating predicts better maintenance of cognitive skills and is associated with a reduced risk of developing Alzheimer's disease in late life. Our review focuses on longitudinal evidence of a connection between an active lifestyle and enhanced cognition, because such evidence admits fewer rival explanations of observed effects (or lack of effects) than does cross-sectional evidence. The longitudinal evidence consistently shows that engaging in intellectually stimulating activities is associated with better cognitive functioning at later points in time. Other studies show that meaningful social engagement is also predictive of better maintenance of cognitive functioning in old age. These longitudinal findings are also open to important rival explanations, but overall, the available evidence suggests that activities can postpone decline, attenuate decline, or provide prosthetic benefit in the face of normative cognitive decline, while at the same time indicating that late-life cognitive changes can result in curtailment of activities. Given the complexity of the dynamic reciprocal relationships between stimulating activities and cognitive function in old age, additional research will be needed to address the extent to which observed effects validate a causal influence of an intellectually engaged lifestyle on cognition. Nevertheless, the hypothesis that an active lifestyle that requires cognitive effort has long-term benefits for older adults' cognition is at least consistent with the available data. Furthermore, new intervention research that involves multimodal interventions focusing on goal-directed action requiring cognition (such as reading to children) and social interaction will help to address whether an active lifestyle enhances cognitive function. Third, there is a parallel literature suggesting that physical activity, and aerobic exercise in particular, enhances older adults' cognitive function. Unlike the literature on an active lifestyle, there is already an impressive array of work with humans and animal populations showing that exercise interventions have substantial benefits for cognitive function, particularly for aspects of fluid intelligence and executive function. Recent neuroscience research on this topic indicates that exercise has substantial effects on brain morphology and function, representing a plausible brain substrate for the observed effects of aerobic exercise and other activities on cognition. Our review identifies a number of areas where additional research is needed to address critical questions. For example, there is considerable epidemiological evidence that stress and chronic psychological distress are negatively associated with changes in cognition. In contrast, less is known about how positive attributes, such as self-efficacy, a sense of control, and a sense of meaning in life, might contribute to preservation of cognitive function in old age. It is well known that certain personality characteristics such as conscientiousness predict adherence to an exercise regimen, but we do not know whether these attributes are also relevant to predicting maintenance of cognitive function or effective compensation for cognitive decline when it occurs. Likewise, more information is needed on the factors that encourage maintenance of an active lifestyle in old age in the face of elevated risk for physiological decline, mechanical wear and tear on the body, and incidence of diseases with disabling consequences, and whether efforts to maintain an active lifestyle are associated with successful aging, both in terms of cognitive function and psychological and emotional well-being. We also discuss briefly some interesting issues for society and public policy regarding cognitive-enrichment effects. For example, should efforts to enhance cognitive function be included as part of a general prevention model for enhancing health and vitality in old age? We also comment on the recent trend of business marketing interventions claimed to build brain power and prevent age-related cognitive decline, and the desirability of direct research evidence to back claims of effectiveness for specific products.
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Hueluer, Gizem, and George W. Rebok. "THE ROLE OF WORK AND RETIREMENT IN COGNITIVE AND BRAIN AGING." Innovation in Aging 3, Supplement_1 (November 2019): S24. http://dx.doi.org/10.1093/geroni/igz038.090.
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Abstract According to the “use it or lose it” hypothesis of cognitive aging, cognitive enrichment and cognitively engaging activities are associated with the maintenance of high levels of cognitive functioning in old age. Similar ideas have been brought forward with respect to characteristics of individuals’ work environment, with more cognitively enriching work demands providing an optimal environment for cognitive development and maintenance. The goal of this research group is to showcase new developments in research on work, retirement and cognitive aging. Hülür et al. examine the role of perceived work environment for cohort differences in trajectories of cognitive change based on 56-year longitudinal data from the Seattle Longitudinal Study. Andel et al. use data from the Swedish Adoption/Twin Study of Aging to examine trajectories of cognitive aging before vs. after retirement with two-slope growth curve models. Zulka et al. conduct a systematic literature review on the association between retirement and cognition and examine the role of factors such as occupational experiences and the cognitive domain studied. Burzynska et al. investigate the relationship between stressful and stimulating occupational exposures and structural brain health and cognition in older age. The discussion by George Rebok will focus on how these findings contribute to our understanding of the role of occupational experiences for cognitive and brain aging and how they can be utilized to promote maintenance of cognitive functioning in old age.
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Yang, Lei, and Zhenbo Wang. "Early-Life Conditions and Cognitive Function in Middle-and Old-Aged Chinese Adults: A Longitudinal Study." International Journal of Environmental Research and Public Health 17, no. 10 (May 15, 2020): 3451. http://dx.doi.org/10.3390/ijerph17103451.
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A range of previous studies have suggested that early-life conditions (ELCs) are associated with various health problems throughout life in Western societies. The aim of this study was to investigate whether, and how, early-life conditions predicted the level and trajectory of cognitive function in middle- and old-aged Chinese adults. Data were obtained from China Health and Retirement Longitudinal Study which comprised 16,258 adults at baseline. Cognitive function was assessed using mental intactness and episodic memory and ELCs were measured by early parental death, childhood socioeconomic status (SES), food deprivation, and childhood health. Growth curve modeling was used to examine the trajectory of cognitive function (three waves in a 6-year period)with particular attention paid to the effects of ELCs on cognition. The results show that early maternal death is associated with the baseline cognitive level among middle- and old-aged Chinese adults (β range between −0.44 and −0.35, p < 0.05), but that this association is also largely attenuated by adulthood education. Higher childhood SES predicts an enhanced level of baseline cognition in both age groups (β range between 0.08 and 1.27, p < 0.001), but only protects against cognitive decline at baseline in middle-aged adults. Participants who were less healthy during childhood tended to have lower cognitive performance than those who had enjoyed good health (β range between −0.36 and −0.14, p < 0.05). The results of this study highlight the detrimental impact of deleterious ELCs on cognitive function throughout later life.
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Schaie, K. Warner. "The impact of longitudinal studies on understanding development from young adulthood to old age." International Journal of Behavioral Development 24, no. 3 (September 2000): 257–66. http://dx.doi.org/10.1080/01650250050118231.
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This essay considers progress in understanding adult development in the study of behaviour during the 20th century. It describes the influence of methodological advances including paradigmatic shifts from cross-sectional to longitudinal studies, advances in measurement, the impact of confirmatory factor analysis, and consideration of age as the dependent variable. A theoretical framework for understanding adult cognitive development is presented. Different types of longitudinal studies, the issue of structural invariance across age, sources of individual differences and the impact of cohort differences are discussed. Finally projections are made for future research.
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Besser, Lilah M., Lun-Ching Chang, Jana A. Hirsch, Daniel A. Rodriguez, John Renne, Stephen R. Rapp, Annette L. Fitzpatrick, Susan R. Heckbert, Joel D. Kaufman, and Timothy M. Hughes. "Longitudinal Associations between the Neighborhood Built Environment and Cognition in US Older Adults: The Multi-Ethnic Study of Atherosclerosis." International Journal of Environmental Research and Public Health 18, no. 15 (July 28, 2021): 7973. http://dx.doi.org/10.3390/ijerph18157973.
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Few studies have examined associations between neighborhood built environments (BE) and longitudinally measured cognition. We examined whether four BE characteristics were associated with six-year change in global cognition and processing speed. We obtained data on 1816 participants without dementia from the Multi-Ethnic Study of Atherosclerosis. BE measures included social destination density, walking destination density, proportion of land dedicated to retail, and network ratio (street connectivity). Global cognition was measured with the Cognitive Abilities Screening Instrument (CASI) and processing speed with the Digit Symbol Coding test (DSC). Multivariable random intercept logistic models tested associations between neighborhood BE at 2010–2012 and maintained/improved cognition (versus decline) from 2010–2018, and mediation by minutes of physical activity (PA)/week. The sample was an average of 67 years old (standard deviation = 8.2) (first cognitive measurement) and racially/ethnically diverse (29% African American, 11% Chinese, 17% Hispanic, 44% White). Compared to individuals with no walking destinations in the 1-mile surrounding their residence, those with 716 walking destinations (maximum observed) were 1.24 times more likely to have maintain/improved DSC score (Odds ratio: 1.24; 95% confidence interval: 1.03–1.45). No other associations were observed between BE and cognition, and PA minutes/week did not mediate the association between walking destination density and DSC change. This study provides limited evidence for an association between greater neighborhood walking destinations and maintained/improved processing speed in older age and no evidence for associations between the other BE characteristics and cognition. Future studies with finer grained BE and cognitive measures and longer-term follow up may be required.
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Licht, Carmilla M. M., Lise C. van Turenhout, Jan Berend Deijen, Lando L. J. Koppes, Willem van Mechelen, Jos W. R. Twisk, and Madeleine L. Drent. "The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study." International Journal of Endocrinology 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/181327.
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Several studies have demonstrated an association between polymorphisms in the insulin-like growth factor-1 (IGF-1) gene and IGF-1 serum levels. IGF-1 levels have been associated with cognitive functioning in older persons and growth hormone deficient patients. The present study investigates whether IGF-1 polymorphisms, IGF-1 levels, and cognition are interconnected in healthy adults. Data of 277 participants (mean age: 42.4 years) of the Amsterdam Growth and Health Longitudinal Study on IGF-1 promoter polymorphisms, IGF-1 serum level, spatial working memory (SWM), paired associate learning (PAL), and IQ tests were analyzed. (M)ANOVAs were applied to confirm the associations between IGF-1 polymorphisms and IGF-1 levels and between IGF-1 levels and cognition. Three groups were distinguished based on specific IGF-1 polymorphism alleles: a homozygote 192 bp/192 bp genotype, a heterozygote 192 bp/x genotype, and a noncarrier x/x genotype. Although different IGF-1 levels were found for the three genotypes, performance on all cognitive tasks and IQ measures was similar. Despite the associations between IGF-1 polymorphisms and IGF-1 levels, no association was found between cognition and IGF-1 levels. It seems that IGF-1 does not play a role in the cognitive performance of healthy middle-aged adults. Possible, IGF-1 fulfills a more developmental and protective role in cognition which becomes apparent during childhood, old-age, or disease.
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Rodriguez, Francisca S., Alexander Pabst, Kathrin Heser, Luca Kleineidam, Andre Hajek, Marion Eisele, Susanne Röhr, et al. "Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)." Journal of Alzheimer's Disease 79, no. 4 (February 16, 2021): 1589–99. http://dx.doi.org/10.3233/jad-201008.
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Background: Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer’s disease and related dementias. Objectives: The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events. Methods: Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson’s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant’s general practitioner. Results: Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant. Conclusion: Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.
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Huang, Chang-Quan, Zheng-Rong Wang, Yong-Hong Li, Yi-Zhou Xie, and Qing-Xiu Liu. "Cognitive function and risk for depression in old age: a meta-analysis of published literature." International Psychogeriatrics 23, no. 4 (October 12, 2010): 516–25. http://dx.doi.org/10.1017/s1041610210000049.
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ABSTRACTBackground: We assessed the relationship between cognitive impairment (including mild cognitive impairment with no signs of dementia, and dementia) and risk for depression in old age (60 years and older).Methods: MEDLINE, EMBASE and the Cochrane Library database were used to identify potential studies. All of the clinical studies that produced data on the association between cognitive function and risk of depression among individuals aged 55 years or older were identified and included in this review. The studies were classified into cross-sectional and longitudinal subsets. The quantitative meta-analysis of cross-sectional and longitudinal studies were performed. For prevalence and incidence rates of depression, odds risk (OR) and relative risk (RR) were calculated, respectively.Results: Since all but two studies found in the search were for individuals aged 60 years or over, we assessed and reported on results for this larger group only. In this review we included 13 cross-sectional and four prospective longitudinal studies. The quantitative meta-analysis showed that, in old age, individuals with non-dementia cognitive impairment had neither significant higher prevalence nor incidence rates of depression than those without (odds risk (OR): 1.48, 95% confidence intervals (95% CI): 0.87–2.52; relative risk (RR): 1.12, 95% CI: 0.62–2.01). In old age, individuals with dementia had both significant higher prevalence and incidence rates of depression than those without (OR: 1.82, 95% CI: 1.15–2.89; RR: 3.92, 95% CI: 1.93–7.99).Conclusions: Despite the methodological limitations of this meta-analysis, we found that in old age, there was no association between depression and cognitive impairment with no dementia; however, there was a definite association between depression and dementia and thus dementia might be a risk for depression.
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Robinson, Andrew C., Roseanne McNamee, Yvonne S. Davidson, Michael A. Horan, Julie S. Snowden, Lynn McInnes, Neil Pendleton, and David M. A. Mann. "Scores Obtained from a Simple Cognitive Test of Visuospatial Episodic Memory Performed Decades before Death Are Associated with the Ultimate Presence of Alzheimer Disease Pathology." Dementia and Geriatric Cognitive Disorders 45, no. 1-2 (2018): 79–90. http://dx.doi.org/10.1159/000486827.
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Background: Community- or population-based longitudinal studies of cognitive ability with a brain donation end point offer an opportunity to examine relationships between pathology and cognitive state prior to death. Discriminating the earliest signs of dementing disorders, such as Alzheimer disease (AD), is necessary to undertake early interventions and treatments. Methods: The neuropathological profile of brains donated from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age, including CERAD (Consortium to Establish a Registry for Alzheimer’s Disease) and Braak stage, was assessed by immunohistochemistry. Cognitive test scores collected 20 years prior to death were correlated with the extent of AD pathology present at death. Results: Baseline scores from the Memory Circle test had the ability to distinguish between individuals who developed substantial AD pathology and those with no, or low, AD pathology. Predicted test scores at the age of 65 years also discriminated between these pathology groups. The addition of APOE genotype further improved the discriminatory ability of the model. Conclusions: The results raise the possibility of identifying individuals at future risk of the neuropathological changes associated with AD over 20 years before death using a simple cognitive test. This work may facilitate early interventions, therapeutics and treatments for AD by identifying at-risk and minimally affected (in pathological terms) individuals.
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Forte, Giuseppe, and Maria Casagrande. "Effects of Blood Pressure on Cognitive Performance in Aging: A Systematic Review." Brain Sciences 10, no. 12 (November 27, 2020): 919. http://dx.doi.org/10.3390/brainsci10120919.
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Introduction: Cognitive functions play a crucial role in daily functioning. Unfortunately, some cognitive abilities decline in the process of healthy aging. An increasing body of evidence has highlighted the role of lifestyle habits and cardiovascular diseases, such as high blood pressure, in increasing the risk of cognitive decline. Surprisingly, although hypertension is a modifiable risk factor for cerebrovascular damage, the role of hypertension on cognitive impairment development is not still clear. Several key questions remain unresolved, and there are many inconsistent results in studies considering this topic. This review is aimed to systematically analyze the results found by the studies that investigated whether high blood pressure, in both hypertensive and healthy people, is related to cognitive performance. Furthermore, it points to evaluate the role of age in this relationship. Method: The review process was conducted according to the PRISMA statement. Restrictions were made, selecting the studies in English and published in peer-review journals, including at least one cognitive measure and blood pressure measurement. Studies that included participants with medical conditions, dementia, psychiatric disorders, strokes, and brain injury were excluded. Cross-sectional and longitudinal studies were analyzed separately. Finally, blood pressure measured at young life (18–39 years), midlife (age 40–64 years), elderly (65–74 years), and old age (≥75 years) were considered. Results: The review allows 68 studies to be selected, which include 154,935 participants. The results provided evidence of an adverse effect of exposure to high blood pressure on cognitive performance. High blood pressure in midlife was linked with poorer cognitive functioning; this evidence was found in cross-sectional and longitudinal studies. However, this association declines with increasing age and tends to become inconsistent. In older people, the relationship between blood pressure and cognitive performance is non-linear, highlighting a beneficial effect of high blood pressure on cognition. Conclusions: Despite some limitations, this review showed that cardiovascular and neuro-cognitive systems do not operate in isolation, but they are related. Blood pressure can be considered an early biomarker of cognitive impairment, and the necessity of early blood pressure measurement and control was underlined.
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Van Baarsen, Berna, Marijtje A. J. Van Duijn, Johannes H. Smit, Tom A. B. Snijders, and Kees P. M. Knipscheer. "Patterns of Adjustment to Partner Loss in Old Age: The Widowhood Adaptation Longitudinal Study." OMEGA - Journal of Death and Dying 44, no. 1 (February 2002): 5–36. http://dx.doi.org/10.2190/pdux-be94-m4el-0pdk.
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The present longitudinal study aims to explain emotional and social loneliness experienced by older adults ( N=99) during two-and-a-half years of widowhood. Utilization of multilevel analysis and a “visual” cluster analysis with prescribed classification criteria enabled us to search for average adaptational developments as well as individual variability in the adjustment process. Results were interpreted within the theory of mental incongruity. Adjustment to loneliness appears to develop along different individual-specific curves. About 30 percent of the bereaved had not adapted in two-and-a-half years to their loss in terms of emotional loneliness. Presence of favorable opportunities such as good health and high self-esteem as well as coping efforts like social behavior resulted in lower levels of emotional and social loneliness. It is concluded that the adjustment process among older bereaved does not exist. Moreover, including measures of cognitions and attitudes that are related to the relational needs and desires of widow(er)s may enlarge our knowledge of how older adults adapt to partner death.
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Romeiser, Jamie L., Dylan M. Smith, and Sean A. P. Clouston. "Musical instrument engagement across the life course and episodic memory in late life: An analysis of 60 years of longitudinal data from the Wisconsin Longitudinal Study." PLOS ONE 16, no. 6 (June 24, 2021): e0253053. http://dx.doi.org/10.1371/journal.pone.0253053.
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Background As the global burden of dementia increases, the absence of treatment underscores the need for identification of factors that may improve cognitive reserve–the ability to stave off cognitive decline in old age. The beneficial association between musical instrument engagement and episodic memory has been identified in children, young adults, and older adults. Yet, previous studies in musical instrument engagement have rarely examined the potential for adolescence and adulthood exposures to independently improve cognition, nor have they been linked with the rate of memory decline over time in older adults. We investigated whether adolescent musical instrument engagement and continued musical instrument engagement over the adult life course were separately associated with higher episodic memory, as well as rate of decline in a large longitudinal cohort. Methods Data were from a prospective cohort of high school graduates from 1957. High school music engagement (HSME) was ascertained through graduate yearbooks and assessed as membership in musical performance groups. A questionnaire was used to assess musical engagement through adulthood (MEA) at ages 35, 55, and 65. The episodic memory score was composed of immediate and delayed recall task scores, and was assessed when participants were aged approximately 65 and 72 years old among 5,718 individuals. Linear mixed models were used to assess the association between music, and memory performance and decline over time. Results Of high school graduates who participated in the study, 38.1% played music in high school, and 21.1% played music in adulthood. While musical engagement was more common in those who played in childhood, 40% of those who played continuously as an adult did not play in high school. High HSME (B = 0.348, p = 0.049) and continuous MEA (B = 0.424, p = 0.012) were associated with higher memory scores at age 65 after covariate adjustment. When examining memory decline, the benefits of high HSME decreased over time (B = -0.435, p = 0.048), while the rate of decline did not differ between MEA groups. Exploratory models revealed differential benefits for HSME and immediate recall, and MEA and delayed recall. Conclusion This study provides further evidence that musical engagement in childhood or adulthood is associated with non-musical cognitive reserve. These two exposures may act differentially in different domains of episodic memory. Further work is needed to determine the relationship between musicianship and the rate of cognitive decline.
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Terrera, Graciela Muniz, Carol Brayne, and Fiona Matthews. "One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors." International Psychogeriatrics 22, no. 2 (November 12, 2009): 291–99. http://dx.doi.org/10.1017/s1041610209990937.
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ABSTRACTBackground: Cognitive decline in old age varies among individuals. The identification of groups of individuals with similar patterns of cognitive change over time may improve our ability to see whether the effect of risk factors is consistent across groups.Methods: Whilst accounting for the missing data, growth mixture models (GMM) were fitted to data from four interview waves of a population-based longitudinal study of aging, the Cambridge City over 75 Cohort Study (CC75C). At all interviews global cognition was assessed using the Mini-mental State Examination (MMSE).Results: Three patterns were identified: a slow decline with age from a baseline of cognitive ability (41% of sample), an accelerating decline from a baseline of cognitive impairment (54% of sample) and a steep constant decline also from a baseline of cognitive impairment (5% of sample). Lower cognitive scores in those with less education were seen at baseline for the first two groups. Only in those with good performance and steady decline was the effect of education strong, with an increased rate of decline associated with poor education. Good mobility was associated with higher initial score in the group with accelerating change but not with rate of decline.Conclusion: Using these analytical methods it is possible to detect different patterns of cognitive change with age. In this investigation the effect of education differs with group. To understand the relationship of potential risk factors for cognitive decline, careful attention to dropout and appropriate analytical methods, in addition to long-term detailed studies of the population points, are required.
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Perry, Susan. "Behavioural variation and learning across the lifespan in wild white-faced capuchin monkeys." Philosophical Transactions of the Royal Society B: Biological Sciences 375, no. 1803 (June 2020): 20190494. http://dx.doi.org/10.1098/rstb.2019.0494.
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Natural selection has evidently mediated many species characteristics relevant to the evolution of learning, including longevity, length of the juvenile period, social organization, timing of cognitive and motor development, and age-related shifts in behavioural propensities such as activity level, flexibility in problem-solving and motivation to seek new information. Longitudinal studies of wild populations can document such changes in behavioural propensities, providing critical information about the contexts in which learning strategies develop, in environments similar to those in which learning strategies evolved. The Lomas Barbudal Monkey Project provides developmental data for the white-faced capuchin, Cebus capucinus , a species that has converged with humans regarding many life-history and behavioural characteristics. In this dataset, focused primarily on learned aspects of foraging behaviour, younger capuchins are more active overall, more curious and opportunistic, and more prone to inventing new investigative and foraging-related behaviours. Younger individuals more often seek social information by watching other foragers (especially older foragers). Younger individuals are more creative, playful and inventive, and less neophobic, exhibiting a wider range of behaviours when engaged in extractive foraging. Whereas adults more often stick with old solutions, younger individuals often incorporate recently acquired experience (both social and asocial) when foraging. This article is part of the theme issue ‘Life history and learning: how childhood, caregiving and old age shape cognition and culture in humans and other animals'.
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Panza, Francesco, Madia Lozupone, Rodolfo Sardone, Petronilla Battista, Marco Piccininni, Vittorio Dibello, Maddalena La Montagna, et al. "Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life." Therapeutic Advances in Chronic Disease 10 (November 9, 2018): 204062231881100. http://dx.doi.org/10.1177/2040622318811000.
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The peripheral hearing alterations and central auditory processing disorder (CAPD) associated with age-related hearing loss (ARHL), may impact cognitive disorders in older age. In older age, ARHL is also a significant marker for frailty, another age-related multidimensional clinical condition with a nonspecific state of vulnerability, reduced multisystem physiological reserve, and decreased resistance to different stressors (i.e. sensorial impairments, psychosocial stress, diseases, injuries). The multidimensional nature of frailty required an approach based on different pathogeneses because this clinical condition may include sensorial, physical, social, nutritional, cognitive, and psychological phenotypes. In the present narrative review, the cumulative epidemiological evidence coming from several longitudinal population-based studies, suggested convincing links between peripheral ARHL and incident cognitive decline and dementia. Moreover, a few longitudinal case-control and population-based studies also suggested that age-related CAPD in ARHL, may be central in determining an increased risk of incident cognitive decline, dementia, and Alzheimer’s disease (AD). Cumulative meta-analytic evidence confirmed cross-sectional and longitudinal association of both peripheral ARHL and age-related CAPD with different domains of cognitive functions, mild cognitive impairment, and dementia, while the association with dementia subtypes such as AD and vascular dementia remained unclear. However, ARHL may represent a modifiable condition and a possible target for secondary prevention of cognitive impairment in older age, social isolation, late-life depression, and frailty. Further research is required to determine whether broader hearing rehabilitative interventions including coordinated counseling and environmental accommodations could delay or halt cognitive and global decline in the oldest old with both ARHL and dementia.
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Cardona, Juan F., Facundo Manes, Josefina Escobar, Jéssica López, and Agustín Ibáñez. "Potential Consequences of Abandonment in Preschool-Age: Neuropsychological Findings in Institutionalized Children." Behavioural Neurology 25, no. 4 (2012): 291–301. http://dx.doi.org/10.1155/2012/782624.
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Objective:Several longitudinal studies had shown that early deprivation and institutionalization during the first six months of life affects the emotional, cognitive, social and neurophysiologic development. Nevertheless, our understanding of possible similar effects of delayed institutionalization, in preschool-age remains unclear to this day. The goal of this study is to evaluate the cognitive performance of institutionalized children with history of preschool-age physical abandonment.Method:18 male institutionalized children with history of abandonment during the preschool-age (2–5 years old) and comparison group matched by age, handedness, gender, educational and socioeconomic level were tested on multiple tasks of attention, memory and executive functions.Results:We found a cognitive impairment in the institutionalized children in several measures of attention, memory and executive functions. This is the first report of cognitive impairment related to late abandonment and institutionalization effects (after 2 years old), extending the already known effects on early institutionalization.Conclusions:This preliminary study suggests that environmental factors including abandonment and institutional care, can affect not only the infancy period, but also the preschool period providing new insights into our understanding of neurocognitive development.
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Nyqvist, Fredrica, Janna Gustavsson, and Yngve Gustafsson. "Social Capital and Health in the Oldest Old." International Journal of Ageing and Later Life 1, no. 1 (June 20, 2006): 91–114. http://dx.doi.org/10.3384/ijal.1652-8670.061191.
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The aim of this study was to measure social capital in the oldest old, and its association with different dimensions of health. The Umeå 85+ study is a cross-sectional study of 253 people, aged 85 years, 90 years and 95 years or older. A principal component factor analysis was performed to assess classes of information measuring the structural and the cognitive components of social capital on an individual level. In the final model, one factor consisting of attachment, social integration and social network emerged which accounted for 55 per cent of the total variance. We analysed the association between structural social capital and various dimensions of health such as depressive symptoms, functional ability and self-rated health. This study suggests that structural social capital may partially explain depressive symptoms but not functional ability or self-rated health. We conclude that social capital is a relevant resource for the oldest old, but we suggest a different approach when measuring social capital in this age group, such as conducting a longitudinal study or including retrospective questions in the study. The oldest old may have had a high level of social capital, but our study could not identify this statistically.
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Ouanes, S., E. Castelao, A. Von Gunten, M. Preisig, and J. Popp. "Cortisol, life events and cognition in non-demented subjects: A population-based study." European Psychiatry 33, S1 (March 2016): S77—S78. http://dx.doi.org/10.1016/j.eurpsy.2016.01.021.
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BackgroundOlder people are particularly exposed to stressful events, known to activate the hypothalamus-pituitary-adrenal axis. Many studies highlighted the possible deleterious effects of elevated cortisol on cognition, assuming a likely role of stressful events. Yet, very few studies actually examined these assumed links between life events, cortisol and cognition.ObjectiveTo examine associations between salivary cortisol, cognition and life events in a population of non-demented old individuals.MethodsA cross-sectional analysis was conducted using data from Colaus/PsyColaus, a longitudinal population-based study involving 6733 Lausanne residents. Salivary cortisol samples (upon waking, 30 minutes after waking, at 11 am and at 8 pm) were obtained from 799 non-demented participants aged at least 60.Life events, activities of daily life along with depressive symptoms were assessed using a standardized questionnaire. A comprehensive neuropsychological test battery was used to determine the Clinical Dementia Rating (CDR).For multiple comparisons, P values were adjusted (P′) according to Holm-Bonferroni's method.ResultsCortisol at 11 am and cortisol area under the curve (AUC) were positively correlated with CDR sum of boxes (CDRSOB) scores (P′ = 0.035; Rho = 0.097 and P′ = 0.024; Rho = 0.110, respectively). The association between cortisol AUC and CDRSOB remained significant after controlling for age, sex, body mass index, education, smoking and depression (P = 0.001; β = 0.001; R2 change = 0.016).The number and the total impact of life events were associated neither with cortisol nor with CDRSOB.ConclusionsElevated cortisol was associated with poorer cognitive functioning yet independently of life events. This suggests that the increased cortisol associated with poorer cognition might be not a mere reflection of stressful events but rather explained by other factors, yet to be elucidated.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Silverstein, Merril, Woosang Hwang, and Joseph Blankholm. "Tracing the Religious Life Course: Intergenerational Sources of Later Life Religiosity." Innovation in Aging 4, Supplement_1 (December 1, 2020): 657. http://dx.doi.org/10.1093/geroni/igaa057.2268.
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Abstract The development of religiosity in later life has its origins in earlier phases of the life course, yet few studies have investigated the contribution of early forms of religious exposure to religious beliefs and behaviors in old age. This investigation uses multigenerational data from the Longitudinal Study of Generations taken from 385 baby-boom children age 16-26 and their parents, linked to religious orientations of these children in midlife and old age. Relying on the “chains of risk” perspective, we found that parental religious intensity in 1971 strengthened their children’s behavioral and cognitive religiosity in later life through their indirect effects on children’s early and midlife religiosity. Our results demonstrate both intergenerational and life course forms of stability in religious belief and practice. Evidence suggests that parental influence creates religious momentum in their children that carries from adolescence/young adulthood through the unfolding of human lives into old age. Part of a symposium sponsored by the Religion, Spirituality and Aging Interest Group.
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Boyle, Patricia A., Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, and David A. Bennett. "To what degree is late life cognitive decline driven by age-related neuropathologies?" Brain 144, no. 7 (March 20, 2021): 2166–75. http://dx.doi.org/10.1093/brain/awab092.
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Abstract The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated that the three most studied of these, Alzheimer’s disease, infarcts, and Lewy bodies, account for ∼40% of the variation in late life cognitive decline. However, that estimate did not incorporate many other diseases that are now recognized as potent drivers of cognitive decline [e.g. limbic predominant age-related TDP-43 encephalopathy (LATE-NC), hippocampal sclerosis, other cerebrovascular conditions]. We examined the degree to which person-specific cognitive decline in old age is driven by a wide array of neuropathologies. Deceased participants (n = 1164) from two longitudinal clinical-pathological studies, the Rush Memory and Aging Project and Religious Orders Study, completed up to 24 annual evaluations including 17 cognitive performance tests and underwent brain autopsy. Neuropathological examinations provided 11 pathological indices, including markers of Alzheimer’s disease, non- Alzheimer’s disease neurodegenerative diseases (i.e. LATE-NC, hippocampal sclerosis, Lewy bodies), and cerebrovascular conditions (i.e. macroscopic infarcts, microinfarcts, cerebral amyloid angiopathy, atherosclerosis, and arteriolosclerosis). Mixed effects models examined the linear relation of pathological indices with global cognitive decline, and random change point models examined the relation of the pathological indices with the onset of terminal decline and rates of preterminal and terminal decline. Cognition declined an average of about 0.10 unit per year (estimate = −0.101, SE = 0.003, P < 0.001) with considerable heterogeneity in rates of decline (variance estimate for the person-specific slope of decline was 0.0094, P < 0.001). When considered separately, 10 of 11 pathological indices were associated with faster decline and accounted for between 2% and 34% of the variation in decline, respectively. When considered simultaneously, the 11 pathological indices together accounted for 43% of the variation in decline; Alzheimer’s disease-related indices accounted for 30–36% of the variation, non-Alzheimer’s disease neurodegenerative indices 4–10%, and cerebrovascular indices 3–8%. Finally, the 11 pathological indices combined accounted for less than a third of the variation in the onset of terminal decline (28%) and rates of preterminal (32%) and terminal decline (19%). Although age-related neuropathologies account for a large proportion of the variation in late life cognitive decline, considerable variation remains unexplained even after considering a wide array of neuropathologies. These findings highlight the complexity of cognitive ageing and have important implications for the ongoing effort to develop effective therapeutics and identify novel treatment targets.
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Tamnes, Christian K., Kristine B. Walhovd, Håkon Grydeland, Dominic Holland, Ylva Østby, Anders M. Dale, and Anders M. Fjell. "Longitudinal Working Memory Development Is Related to Structural Maturation of Frontal and Parietal Cortices." Journal of Cognitive Neuroscience 25, no. 10 (October 2013): 1611–23. http://dx.doi.org/10.1162/jocn_a_00434.
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Parallels between patterns of brain maturation and cognitive development have been observed repeatedly, but studies directly testing the relationships between improvements in specific cognitive functions and structural changes in the brain are lacking. Working memory development extends throughout childhood and adolescence and likely plays a central role for cognitive development in multiple domains and in several neurodevelopmental disorders. Neuroimaging, lesion, and electrophysiological studies indicate that working memory emerges from coordinated interactions of a distributed neural network in which fronto-parietal cortical regions are critical. In the current study, verbal working memory function, as indexed by performance on the Keep Track task, and volumes of brain regions were assessed at two time points in 79 healthy children and adolescents in the age range of 8–22 years. Longitudinal change in cortical and subcortical volumes was quantified by the use of Quantitative Anatomical Regional Change. Improvement in working memory was related to cortical volume reduction in bilateral prefrontal and posterior parietal regions and in regions around the central sulci. Importantly, these relationships were not explained by differences in gender, age, or intelligence level or change in intellectual abilities. Furthermore, the relationships did not interact with age and were not significantly different in children, young adolescents, and old adolescents. The results provide the first direct evidence that structural maturation of a fronto-parietal cortical network supports working memory development.
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Lövdén, Martin, Laura Fratiglioni, M. Maria Glymour, Ulman Lindenberger, and Elliot M. Tucker-Drob. "Education and Cognitive Functioning Across the Life Span." Psychological Science in the Public Interest 21, no. 1 (August 2020): 6–41. http://dx.doi.org/10.1177/1529100620920576.
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Cognitive abilities are important predictors of educational and occupational performance, socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to impairments in older adults’ everyday functions, but people differ from one another in their rates of cognitive decline over the course of adulthood and old age. Hence, identifying factors that protect against compromised late-life cognition is of great societal interest. The number of years of formal education completed by individuals is positively correlated with their cognitive function throughout adulthood and predicts lower risk of dementia late in life. These observations have led to the propositions that prolonging education might (a) affect cognitive ability and (b) attenuate aging-associated declines in cognition. We evaluate these propositions by reviewing the literature on educational attainment and cognitive aging, including recent analyses of data harmonized across multiple longitudinal cohort studies and related meta-analyses. In line with the first proposition, the evidence indicates that educational attainment has positive effects on cognitive function. We also find evidence that cognitive abilities are associated with selection into longer durations of education and that there are common factors (e.g., parental socioeconomic resources) that affect both educational attainment and cognitive development. There is likely reciprocal interplay among these factors, and among cognitive abilities, during development. Education–cognitive ability associations are apparent across the entire adult life span and across the full range of education levels, including (to some degree) tertiary education. However, contrary to the second proposition, we find that associations between education and aging-associated cognitive declines are negligible and that a threshold model of dementia can account for the association between educational attainment and late-life dementia risk. We conclude that educational attainment exerts its influences on late-life cognitive function primarily by contributing to individual differences in cognitive skills that emerge in early adulthood but persist into older age. We also note that the widespread absence of educational influences on rates of cognitive decline puts constraints on theoretical notions of cognitive aging, such as the concepts of cognitive reserve and brain maintenance. Improving the conditions that shape development during the first decades of life carries great potential for improving cognitive ability in early adulthood and for reducing public-health burdens related to cognitive aging and dementia.
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Leggieri, Attanasio, Palladino, Cellerino, Lucini, Paolucci, Terzibasi Tozzini, de Girolamo, and D’Angelo. "Identification and Expression of Neurotrophin-6 in the Brain of Nothobranchius furzeri: One More Piece in Neurotrophin Research." Journal of Clinical Medicine 8, no. 5 (April 30, 2019): 595. http://dx.doi.org/10.3390/jcm8050595.
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Neurotrophins contribute to the complexity of vertebrate nervous system, being involved in cognition and memory. Abnormalities associated with neurotrophin synthesis may lead to neuropathies, neurodegenerative disorders and age-associated cognitive decline. The genome of teleost fishes contains homologs of some mammalian neurotrophins as well as a gene coding for an additional neurotrophin (NT-6). In this study, we characterized this specific neurotrophin in the short-lived fish Nothobranchius furzeri, a relatively new model for aging studies. Thus, we report herein for the first time the age-related expression of a neurotrophin in a non-mammalian vertebrate. Interestingly, we found comparable expression levels of NT-6 in the brain of both young and old animals. More in detail, we used a locked nucleic acid probe and a riboprobe to investigate the neuroanatomical distribution of NT-6 mRNA revealing a significant expression of the neurotrophin in neurons of the forebrain (olfactory bulbs, dorsal and ventral telencephalon, and several diencephalic nuclei), midbrain (optic tectum, longitudinal tori, and semicircular tori), and hindbrain (valvula and body of cerebellum, reticular formation and octavolateral area of medulla oblongata). By combining in situ hybridization and immunohistochemistry, we showed that NT-6 mRNA is synthesized in mature neurons. These results contribute to better understanding the evolutionary history of neurotrophins in vertebrates, and their role in the adult brain.
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Cadar, Dorina, Lucy Stirland, and Graciela Muniz Terrera. "MULTIMORBIDITY, MENTAL HEALTH, AND TERMINAL DECLINE IN LATER LIFE." Innovation in Aging 3, Supplement_1 (November 2019): S619—S620. http://dx.doi.org/10.1093/geroni/igz038.2308.
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Abstract The close interlink between physical and mental health outcomes has long been recognised in gerontological research. Mental-physical comorbidities – the presence of at least one physical health long term condition, and at least one mental health-related long term condition are common in older age individuals. Numerous studies have shown a positive association between the prevalence of multimorbidity and age so, as the population of older individuals in developed nations continues to grow, multimorbidity is likely to become increasingly higher in ageing populations. A major goal in current gerontological neuropsychology and neuroepidemiological research is to better understand how interindividual differences in cognitive and mental health in old age emerge. Cognitive reserve (a marker of brain resilience) may come into play when facing stressors that affect cognitive decline and mental health, such as suffering from chronic diseases. We present data from three different longitudinal studies of ageing i) the Lothian Birth Cohort of 1921, ii) PREVENT and iii) the English Longitudinal Study of Ageing from the United Kingdom. These studies are ideally placed to address key research questions related to mental ageing, psychological health, terminal decline and their determinants. We explored the following objectives: 1) to investigate the association between an increasing number of chronic physical conditions, medication and mental disorders 2) to assess the role of childhood intelligence and education on the terminal decline in later life 3) to investigate the associations between different markers of cognitive reserve and dementia
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Granone, Francesca, Sandra Damnotti, and Chiara Chicco. "Integrating a Mediated Learning Experience with Karlstad-model: A Longitudinal Study on a One-Year-Old Child with Down Syndrome." International Journal of Social Science Studies 9, no. 4 (June 28, 2021): 35. http://dx.doi.org/10.11114/ijsss.v9i4.5277.
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The study intends to raise a discussion regarding the question of whether a Mediated Learning Experience (MLE) can be considered applicable to children younger than two years with Down Syndrome (DS), to stimulate their cognitive abilities. In fact, currently MLE approach is used mainly for children of at least two years of age. The longitudinal study has been conducted for six months with a one-year-old child with DS (named T.) between 12 and 18-months of age. Sessions of video recording was conducted each week, videotaping the boy and his mother interacting in different object permanence and cause-effect activities. The article presents first a discussion about similar characteristics that can be identified between MLE and the Karlstad-model, an established approach used regularly in Norway to enhance the communication abilities of children with DS already from the first months. Then, the research presents and discusses how simple activities used also to introduce the Karlstad-model for enhancing child’s communication ability can be used to support specific cognitive functions. The study raises interest about the possibility of defining activities suitable for an MLE approach with focus on children younger than two years of age with DS. The results obtained are not generalizable but provide a starting point for discussion that opens up to possible qualitative and quantitative subsequent studies carried out on larger populations.
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Kremen, William S., Carol E. Franz, and Michael J. Lyons. "VETSA: The Vietnam Era Twin Study of Aging." Twin Research and Human Genetics 16, no. 1 (October 30, 2012): 399–402. http://dx.doi.org/10.1017/thg.2012.86.
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The Vietnam Era Twin Study of Aging (VETSA) is a longitudinal behavioral genetic study with a primary focus on cognitive and brain aging in men. It comprises a subset of over 1,200 twins from the Vietnam Era Twin Registry. Like many other studies of aging, the VETSA includes many different phenotypes, but there are some key features that distinguish it from most other behavioral genetic aging studies. First, the initial assessment was conducted when all participants were middle-aged. Second, the age range of participants is narrow; all were in their 50s at the time of the initial recruitment. Third, the study includes an extensive and demanding neurocognitive test battery that was designed to provide good coverage of different cognitive abilities and avoid ceiling effects in middle-aged adults. Fourth, young adult cognitive test data (at an average age of 20 years) are available to provide a gauge of cognitive change. These features make the VETSA ideal for studying the heterogeneity of within-individual trajectories from midlife to old age, and for early detection of risk factors for cognitive decline.
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Pastor-Mallol, Estanislao, and Edith Santó-Rañé. "The ability to manage self-proposed projects between 1;3 and 2;0 years old: a study of inhibition and resistance to interference." Anales de Psicología 31, no. 2 (April 25, 2015): 534. http://dx.doi.org/10.6018/analesps.31.2.159121.
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<p>This study examines very young children’s ability to manage self-proposed projects by using the inhibitory function and resistance to interference. In a natural environment and using an observational method, we conducted a longitudinal study of a sample observed at 1;3, 1;6, 1;9 and 2;0 years old. The research was divided into two studies which followed different procedures and looked at the projects carried out, the interferences produced and the functioning of inhibition. We observed significant differences in the execution of inhibition at the different age groups. We also describe general cognitive functions in terms of significant patterns, and determine that the use of inhibition is linked not only to age but also to the activity complexity level and the type of interference. <strong></strong></p>
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Yoneda, Tomiko, Jonathan Rush, Graciela Muniz Terrera, Almar Kok, Boo Johansson, Scott Hofer, Daniel Mroczek, and Andrea Piccinin. "Inter-Individual and Intra-Individual Relationships Between Neuroticism and Cognition: A Coordinated Analysis." Innovation in Aging 4, Supplement_1 (December 1, 2020): 387–88. http://dx.doi.org/10.1093/geroni/igaa057.1248.
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Abstract Existing literature indicates a relatively consistent relationship between neuroticism and cognitive functioning (CF). Interindividually, high levels of neuroticism may predispose individuals to cognitive aging and dementia-related neuropathology. Intraindividually, increases in neuroticism may be intrinsic to the aging process or to dementia pathology. These hypotheses are not mutually exclusive, though the relationships are rarely examined using the same individuals, which may contribute to publication bias and confusion regarding the hypotheses as mutually exclusive. Data were drawn from the Origins of Variance in the Oldest-Old (Sweden, Mage=83.6, 67% female), Swedish Adoption/Twin Study of Aging (Sweden, Mage=60.4, 59% female), and Longitudinal Aging Study Amsterdam (Netherlands; Mage=68.1, 52% female). Controlling for age, sex, education, and depressive symptoms, parallel process latent growth models were fit independently in each sample (NT=3293) to simultaneously estimate growth parameters of neuroticism with three measures of CF (processing speed, learning/memory, and reasoning). Multilevel meta-analysis estimated the pooled covariation between neuroticism and CF at baseline and overtime, revealing a significantly negative intercept-intercept relationship across datasets (covariance= -0.46, 95% CIs [-0.90,-0.02], z=-2.02, p=0.04, τ2=0.06). The slope-slope covariances were consistently negative, but the meta-analytic pooled estimate was not significant despite some significant individual estimates across studies. Overall, results provide some evidence for intraindividual and interindividual relationships between neuroticism and CF, such that higher neuroticism is associated with lower CF, and neuroticism tends to increase as CF decreases. Identification of the early indicators and risk factors for cognitive decline may facilitate development of screening assessments and aid in treatment strategies for dementia care services.
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Chen, Yao, Chen’Xi’ Nan Ma, Lan Luo, Jieyun Yin, Zhan Gao, Zengli Yu, and Zhongxiao Wan. "The cross-sectional association between mean corpuscular volume level and cognitive function in Chinese over 45 years old: Evidence from the China Health and Retirement Longitudinal Study." PLOS ONE 15, no. 12 (December 3, 2020): e0243227. http://dx.doi.org/10.1371/journal.pone.0243227.
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Fewer studies have focused on the independent association between mean corpuscular volume (MCV) and cognitive performance. This study was designed to characterize the cross-sectional association between MCV and cognitive performance in a large sample of Chinese residents (age≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4023 male and 4173 female adults with MCV ≥ 80 fl were included for analysis. By multivariable linear regression analysis, for the total subjects, MCV level was significantly negatively associated with global cognitive function and episodic memory. When adjusted by sex, only in male subjects, higher MCV level was associated with reduced scores for global cognitive function, episodic memory and mental status. Via binary logistic regression analysis, the higher MCV level (MCV>100 fl) was associated with poor global cognitive function (OR = 1.601; 95% CI = 1.198–2.139; p = 0.001), episodic memory (OR = 1.679; 95% CI = 1.281–2.201; p<0.001), and mental status (OR = 1.422; 95% CI = 1.032–1.959; p = 0.031) for the whole participants. When testing this association by sex, the significant relationship between higher MCV level with worse episodic memory was observed both in male (OR = 1.690; 95% CI = 1.211–2.358; p = 0.002) and female (OR = 1.729; 95% CI = 1.079–2.770; p = 0.023) subjects; while the association between higher MCV level and poor global cognitive function (OR = 1.885; 95% CI = 1.329, 2.675; p<0.001) and mental status (OR = 1.544; 95% CI = 1.034, 2.306; p = 0.034) only existed in male subjects. Further studies are warranted to clarify the association between MCV level and cognitive performance by considering sex into consideration both cross-sectionally and longitudinally.
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Kleineidam, Luca, Andrea R. Zammit, Alyssa DeVito, Richard B. Lipton, Oliver Peters, Alfredo Ramirez, Michael Wagner, and Graciela Muniz Terrera. "THE APOE-ε4 ALLELE AND AGE SYNERGISTICALLY DRIVE DISEASE PROGRESSION IN ALZHEIMER’S DISEASE." Innovation in Aging 3, Supplement_1 (November 2019): S943. http://dx.doi.org/10.1093/geroni/igz038.3427.
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Abstract The Apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD) and other neurodegenerative dementias. Cross-sectional case-control studies suggest that the effect of APOE-ε4 decreases in old age. However, since APOE- ε4 is associated with mortality, these studies might be prone to bias due to selective survival. Therefore, we used multi-state-modeling in longitudinal cohort studies to examine the effect of APOE-ε4 on the transition through cognitive states (i.e. cognitively normal, mild cognitive impairment (MCI) and dementia) while taking death as a competing risk into account. Results from the German AgeCoDe study (n=3000, aged 75-101 years) showed that APOE-ε4 increases the risk for cognitive deterioration in all disease stages. Contrary to results from cross-sectional studies, the effect of APOE-ε4 on the transition from MCI to dementia increased with increasing age (HR=1.044, 95%-CI=1.001-1090). The direction of this effect was confirmed in a smaller sample from the Einstein Aging Study (n=744, HR=1.032, 95%-CI=0.949-1.122). To examine the pathophysiological basis of these results, generalized additive models were used to study AD biomarkers in the liquor of 1045 patients with MCI or AD-dementia. Here, increased amyloid (Abeta1-42) pathology was associated with increased tau pathology (pTau181), consistent with the amyloid-cascade-hypothesis. Interestingly, higher age and presence of the APOE-ε4 synergistically lowered the amount of amyloid required to exacerbate tau pathology (interaction p=0.012). Taken together, our results suggest that the effect of APOE-ε4 on disease progression increases with advancing age. An altered neuroinflammatory response to neurodegeneration should be further explored as potential underlying mechanism.
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LIU, HUEI-MEI, FENG-MING TSAO, and PATRICIA K. KUHL. "Age-related changes in acoustic modifications of Mandarin maternal speech to preverbal infants and five-year-old children: a longitudinal study." Journal of Child Language 36, no. 4 (February 23, 2009): 909–22. http://dx.doi.org/10.1017/s030500090800929x.
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ABSTRACTAcoustic-phonetic exaggeration of infant-directed speech (IDS) is well documented, but few studies address whether these features are modified with a child's age. Mandarin-speaking mothers were recorded while addressing an adult and their child at two ages (0 ; 7–1 ; 0 and 5 ; 0) to examine the acoustic-phonetic differences between IDS and child-directed speech (CDS). CDS exhibits an exaggeration pattern resembling that of IDS – expanded vowel space, longer vowels, higher pitch and greater lexical tone differences – when compared to ADS. Longitudinal analysis demonstrated that the extent of acoustic exaggeration is significantly smaller in CDS than in IDS. Age-related changes in maternal speech provide some support for the hypothesis that mothers adjust their speech directed toward children as a function of the child's language ability.
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Barry, Lisa. "Behavioral and Social Considerations." Innovation in Aging 4, Supplement_1 (December 1, 2020): 855. http://dx.doi.org/10.1093/geroni/igaa057.3147.
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Abstract Cognitive, behavioral and social dimensions also demonstrate increasing heterogeneity with aging. For example, a longitudinal study of over 1,000 clergy revealed increasing heterogeneity in cognitive function and rate of decline with aging. Moreover, studies of individuals with probable Alzheimer’s disease have shown heterogeneity in terms of clinical manifestations and rates of cognitive decline. Older adults also demonstrate greater heterogeneity in mood, anxiety, and the nature and patterns of symptoms over time. Heterogeneity of overall health status increases with aging, as does reported quality of life. Health and Retirement Study (HRS) data have shown that low socioeconomic status or being an underrepresented minority are both associated with greater intra-individual variability in health status in old age, with greatest differences seen in Hispanics. Finally, early life adversity can contribute to heterogeneity of multidimensional health trajectories even in late life.
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Wadhawan, Abhishek, Aline Dagdag, Allyson Duffy, Melanie L. Daue, Kathy A. Ryan, Lisa A. Brenner, John W. Stiller, et al. "Positive association between Toxoplasma gondii IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study." Pteridines 28, no. 3-4 (December 20, 2017): 185–94. http://dx.doi.org/10.1515/pterid-2017-0019.
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AbstractToxoplasma gondii (T. gondii) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have been inconsistent, possibly as a consequence of high heterogeneity. We have now studied this association in a more homogeneous population, [that is (i.e.) Old Order Amish (OOA)] with previously reported high T. gondii seroprevalence. In 306 OOA with a mean age of 46.1±16.7 years, including 191 (62.4%) women in the Amish Wellness Study, we obtained both T. gondii IgG titers (by enzyme-linked immunosorbent assay [ELISA]), and depression screening questionnaires (Patient Health Questionnaire [PHQ-9] [n=280] and PHQ-2 [n=26]). Associations between T. gondii IgG and dysphoria/hopelessness and anhedonia scores on depression screening questionnaires were analyzed using multivariable linear methods with adjustment for age and sex. Serointensity was associated with both current dysphoria/hopelessness (p=0.045) and current combined anhedonia and dysphoria/hopelessness (p=0.043), while associations with simple anhedonia and past/lifelong (rather than current) phenotypes were not significant. These results indicate the need for larger longitudinal studies to corroborate the association between dysphoria/hopelessness and T. gondii IgG-titers. Current hopelessness is a known risk factor for SSDV which responds particularly well to cognitive behavioral therapy, and may be a focused treatment target for T. gondii-positive individuals at high-risk for SSDV.
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Gilbert, Laura, Nicole Dear, Allahna L. Esber, Michael Iroezindu, Emmanuel Bahemana, Hannah Kibuuka, John Owuoth, et al. "1540. Prevalence and Risk Factors associated with HIV and Syphilis Co-infection in the African Cohort Study." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S769—S770. http://dx.doi.org/10.1093/ofid/ofaa439.1720.
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Abstract Background Each year, 6 million new syphilis cases are diagnosed globally. Seroprevalence studies in low-income countries (LIC) are limited but is estimated at 3.5-4.6%. Few studies have researched prevalence of sexually transmitted infections (STIs) in people living with human immunodeficiency virus (HIV; PLWH). Current guidelines for PLWH in LIC recommend STI testing for symptomatic persons and those with a new HIV diagnosis, which may lead to high rates of undiagnosed STIs. Here we provide updated STI prevalence rates and risk factors for syphilis co-infection in PLWH in the African Cohort Study (AFRICOS). Methods AFRICOS is an ongoing longitudinal study enrolling PLWH in four African countries where participants undergo routine medical exams, sociobehavioral questionnaires, and laboratory extraction for study purposes every 6 months. Enrollment syphilis data was extracted to determine screen-positive and serologically-confirmed syphilis prevalence rates for this study. Bivariate and multivariate analysis were performed to determine risk factors for HIV and syphilis co-infection and reported as adjusted prevalence ratios (APR) with 95% confidence intervals (CI). Results Between January 2013 and March 1, 2020, 2883 PLWH enrolled. Prevalence of screen-positive and confirmed syphilis was 5.2% and 3%, respectively. Among PLWH with confirmed syphilis, 58.6% were women, mean age was 37.8 years old (IQR 31.658, 45.011, p = 0.068), and genital ulcers were documented in 1.61% participants. In the multivariate model, participants with confirmed syphilis co-infection were more likely to have none or some primary education [2.65 (1.34, 5.230)], demonstrate impaired cognition [2.1 (1.25, 3.590], and consume alcohol [1.88 (1.19, 2.970] compared to those without syphilis. Conclusion In conclusion, our findings suggest that syphilis rates remain elevated at endemic levels in LIC where diagnosis remains challenging. Based on our analysis, current STI guidelines for PLWH in Africa are likely leading to a large proportion of undiagnosed STIs and potentially contributing to community spread. While this study observed that lower education level, alcoholism, and impaired cognition were associated with syphilis co-infection, further studies are needed to investigate these associations. Disclosures All Authors: No reported disclosures
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Brañas, Marcelo J. A. A., Marcos S. Croci, Ana Beatriz Ravagnani Salto, Victoria F. Doretto, Eduardo Martinho, Marcos Macedo, Euripedes C. Miguel, Leonardo Roever, and Pedro M. Pan. "Neuroimaging Studies of Nonsuicidal Self-Injury in Youth: A Systematic Review." Life 11, no. 8 (July 22, 2021): 729. http://dx.doi.org/10.3390/life11080729.
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Nonsuicidal self-injury (NSSI) is prevalent and affects mainly the youth population. It is prospectively associated with suicide attempts, making it a target for suicide prevention. Recently, several studies have investigated neural pathways of NSSI using neuroimaging. However, there is a lack of systematized appraisal of these findings. This systematic review aims to identify and summarize the main neuroimaging findings of NSSI in youth. We followed PRISMA statement guidelines and searched MEDLINE, APA PsycInfo, and Google Scholar databases for neuroimaging studies, irrespective of imaging modality, specifically investigating NSSI in samples with a mean age of up to 25 years old. Quality assessment was made using the Newcastle–Ottawa and Joanna Briggs Institute scales. The initial search retrieved 3030 articles; 21 met inclusion criteria, with a total of 938 subjects. Eighteen studies employed functional neuroimaging techniques such as resting-state and task-based fMRI (emotional, interpersonal exposure/social exclusion, pain, reward, and cognitive processing paradigms). Three studies reported on structural MRI. An association of NSSI behavior and altered emotional processing in cortico-limbic neurocircuitry was commonly reported. Additionally, alterations in potential circuits involving pain, reward, interpersonal, self-processing, and executive function control processes were identified. NSSI has complex and diverse neural underpinnings. Future longitudinal studies are needed to understand its developmental aspects better.
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Sastre, Vanessa, Daniel Lapresa, Javier Arana, Rafael Ibáñez, and M. Teresa Anguera. "Observational Analysis of Lateral Preference in Kumite Initiation: A Starting Point in the Longitudinal Programming of Formative Karate." Perceptual and Motor Skills 128, no. 5 (August 9, 2021): 2367–80. http://dx.doi.org/10.1177/00315125211039198.
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We used observational methodology to analyze lateral conditioning in the technical-tactical performance of high level 8–9-year-old karatekas, specifically in relation to the guard action that supports the technical action and the body segment with which it is performed. We designed an ad hoc observation instrument to analyze lateral preference in the technical-tactical actions that take place during the kumite. We relied on LINCE software for data registration, and we found good inter-observer reliability, calculated with Cohen's Kappa coefficient. Generalizability Theory supported the homogeneity of the behavior deployed by these combatants. Our results represent a starting point in the longitudinal programming of karate. By relating our results and those of other studies that have addressed lateral performance in formative karate in the kumite modality, we are able to draw a roadmap of a karateka's path towards the equilaterality that is inherent in an elite competitor: (a) the 8-9 year old karateka must overcome a conditioned lateral prevalence by adopting a forward non-dominant leg guard so as to then attack with the dominant body segment; (b) the eqilateral use of the right or left fist must occur later, between the 12–13 year age group and the senior category; and (c) there will then be less decisive lateral conditioning in the execution of offensive leg techniques.
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Segel-Karpas, Dikla, Amit Shrira, and Margie E. Lachman. "AN ECOLOGICAL MOMENTARY OUTLOOK ON SUBJECTIVE AGING." Innovation in Aging 3, Supplement_1 (November 2019): S50—S51. http://dx.doi.org/10.1093/geroni/igz038.198.
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Abstract Cross-sectional and longitudinal studies showed that subjective age – individuals’ perceptions of their own age as older or younger in relation to their actual age, is an important predictor of physical, cognitive, and mental health. Despite some initial findings suggesting that subjective aging responses to variations in the daily experiences, less is known about how daily and momentary experiences shape how old people feel, and how their perceived age affects their daily experiences. In this symposium, five studies using daily diaries and experience sampling methods will be presented and discussed to explore how subjective aging affects, and is affected by, daily changes. In the first presentation, Neupert will discuss her findings regarding the covariation of anticipatory next-day health-related stressors and coping with felt-age, suggesting that forecasting and coping with future stressors play a role in subjective aging. Presenting findings from his experience-moment-sampling study, Hughes will discuss the momentary association between subjective age and mind wandering. Zhang and Segel-Karpas will present findings from studies focusing on attitudes towards aging. Zhang will focus on state vs. trait subjective aging, exploring their association with daily variability in control and competence, while Segel-Karpas will focus on the moderating role of attitudes in the daily associations between subjective age and mental health. Finally, Shrira will present a study of rehabilitation patients, finding that subjective aging is related to physical and mental health, especially for patients with high age-awareness. Professor Lachman will lead a discussion.
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Grant, Shakira J., Lindsay M. Hannan, Jessica L. Brand, Robert E. Richard, Daniel Y. Wu, Solomon A. Graf, Jonathan Grim, Nicholas Burwick, and Thomas R. Chauncey. "Impact of Neurocognitive Dysfunction in a Veteran Population Undergoing First Outpatient Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma." Blood 134, Supplement_1 (November 13, 2019): 5883. http://dx.doi.org/10.1182/blood-2019-122580.
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INTRODUCTION Older adults (age > 70 years) with multiple myeloma (MM) are at higher risk of early mortality partly due to age-related factors, including impairments of cognition and function. To date, few studies have investigated the prevalence of neurocognitive impairment prior to autologous hematopoietic stem cell transplantation (ASCT) and its impact on post-transplant outcomes. We hypothesize, for patients with MM undergoing first outpatient ASCT, age >70 years or the presence of comorbid neurocognitive dysfunction decreases the time to first unplanned hospitalization occurring within 30 days post ASCT, and increases the overall length of stay (LOS) on the transplant service. METHODS We conducted a retrospective cohort study of 76 consecutive patients who underwent first ASCT at the Puget Sound Veterans Health Administration, for MM between January 2017 and December 2018. Patients with the following were excluded: amyloidosis, anaplastic plasmacytoma, and POEMS. Comprehensive psychological evaluations performed within 30 days prior to ASCT included: cognitive screening [Montreal Cognitive Assessment (MOCA)], depression [Patient Health Questionnaire-9 (PHQ-9)], and anxiety [General Anxiety Disorder- 7 (GAD-7)]. Functional status was assessed by activities of daily living (ADLS) and instrumental activities of daily living (IADLS). Data sources for table 1, included the institutional stem cell transplant database, and comprehensive electronic medical record review for each patient. This included vital status as of 7/15/19. Total LOS on the transplant service was measured as the time from arrival until discharge post-engraftment. For eligible patients, all portions of ASCT, including, stem cell collection, conditioning and stem cell infusion were completed as an outpatient. Statistical analyses were performed using SAS version 9.4. Kaplan Meier curves were generated to explore the association of cognitive scores and 1) time until first unplanned hospitalization within 30 days post-ASCT and 2) outpatient LOS on the stem cell transplant service. RESULTS Of the 76 patients undergoing ASCT, median age was 67 (range 40-79), 29% (22/76) were ≥ 70 years old . 67% (51/76) underwent ASCT within 1 year from diagnosis. The majority (73/76) scored ≥ 70 on a provider-assessed Karnofsky performance scale. Of those with MOCA scores available (n=64), impairments in cognition ranged from suspected mild cognitive impairment (MOCA 20-25) to probable cognitive impairment (MOCA 15-19), in 50% (32/64) and 6%( 8/64) of patients respectively. Those with MOCA scores< 26 were more likely to have ≥ 1 IADL impairment compared to those with scores ≥ 26 (Fisher Exact p=0.014). A total of 19 patients underwent planned hospitalization for conditioning followed by stem cell rescue, and therefore were not included in our analysis of unplanned hospitalization. Of the 57% (33/59) of patients with an unplanned inpatient admission within 30 days post-ASCT, the median time to first admission was 11 days. A total of 61% (17/28) and 53%(10/19) patients with MOCA <26 and ≥26, respectively, required hospitalization post-ASCT (log-rank p-value=0.70). There was no difference in the time to first unplanned hospitalization by age (<70, ≥70 years; log-rank p-value 0.58). Median time spent on the transplant service was 78 days (range 30 - 118). Suspected cognitive impairment did not influence time on the outpatient transplant service (median: 79 days MOCA <26 and 77 days MOCA ≥ 26, log-rank p-value=0.38). Median number of days on the transplant service differed by age group (log-rank p-value=0.02),) 76 vs 79 days in those age <70 and ≥70 respectively. CONCLUSION We found a high prevalence of cognitive impairment in MM patients undergoing first ASCT. However, we found no significant association between cognitive impairment or age and 30-day unplanned hospitalization. Older age (>70 years) was associated with a longer transplant service LOS. Thus, select older patients may have higher utilization of hospital resources post-ASCT compared to their younger counterparts. However confounding variables and selection bias may have influenced these preliminary results and additional analyses are ongoing. Future studies will evaluate the impact of age and pre-transplant neurocognitive function on additional outcomes, including longitudinal neurocognitive deterioration and impact on long-term morbidity and mortality. Disclosures Graf: TG Therapeutics: Research Funding; AstraZeneca: Research Funding; BeiGene: Research Funding.
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Johansson, Yvonne A., Catharina Gillsjö, and Elisabeth Kenne Sarenmalm. "Symptoms and Well-Being in Older Hospitalized Patients with Cognitive Impairment, As Self-Reported and Reported in Patient Records: A Quantitative Exploratory Subgroup Analysis." Dementia and Geriatric Cognitive Disorders Extra 11, no. 2 (May 5, 2021): 71–77. http://dx.doi.org/10.1159/000515822.
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<b><i>Introduction:</i></b> Given the aging population and the high prevalence of cognitive impairment in older hospitalized patients, it is essential to provide good fundamental care to these vulnerable patients, who easily might be affected by poor outcomes as delirium. Risk factors for delirium are, for example, cognitive impairment, old age, pain, and sleep deprivation. Different symptoms are often unidentified in hospitals, and associated with poor well-being, but this is rarely studied in older patients with cognitive impairment. The study aim was to examine symptoms and sense of well-being in older hospitalized patients with cognitive impairment, as self-reported and reported in patient records. <b><i>Methods:</i></b> Exploratory quantitative subgroup (<i>n</i> = 25) analysis of a point-prevalence study (<i>n</i> = 210). Inclusion criteria were age ≥65, and cognitive impairment. Data were collected through structured interviews, validated instruments, and patient records. Associations between well-being and symptoms, and concordance between the occurrence of self-reported symptoms and symptoms reported in patient records were analyzed. <b><i>Results:</i></b> The patients reported severe and distressing symptoms that were sparsely reported (14%) in their records. As well were cognitive impairment, and the patients’ own descriptions of their well-being. Some symptoms and the total symptom burden were associated with poor well-being. <b><i>Discussion/Conclusion:</i></b> To our knowledge, this hypothesis-generating study is one of few studies that describe both symptoms and well-being as self-reported and reported in patient records, in vulnerable patients due to old age, cognitive impairment, and hospitalization. Despite the limited sample size, the results indicate that symptoms were more insufficient alleviated in these patients compared to patients with normal cognitive function in other studies. To our knowledge, this has not been shown previously. Additionally, patients’ own experiences were sparsely reported in their records. A larger sample size and longitudinal design has the potential to determine if symptom alleviation differs between patients with and without cognitive impairment, and if a total symptom burden increases the risk of poor outcomes as delirium in vulnerable patients.
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Mutua, Agnes M., Margaret Nampijja, Alison M. Elliott, John M. Pettifor, Thomas N. Williams, Amina Abubakar, Emily L. Webb, and Sarah H. Atkinson. "Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children." Nutrients 12, no. 6 (June 3, 2020): 1662. http://dx.doi.org/10.3390/nu12061662.
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Vitamin D deficiency is common worldwide and young children are among the most affected groups. Animal studies suggest a key role for vitamin D in brain development. However, studies investigating the effects of vitamin D on neurobehavioural outcomes in children are inconclusive and evidence is limited in sub-Saharan Africa. We evaluated the effect of vitamin D status on cognitive and motor outcomes using prospective data from the Entebbe Mother and Baby Study birth cohort. We analysed data from 302 Ugandan children with 25-hydroxyvitamin D (25(OH)D) measurements below five years and developmental measures at five years of age. We used multivariable linear regression, adjusted for potential confounders, to estimate the effect of 25(OH)D on cognitive and motor outcomes. Of 302 children, eight (2.7%) had 25(OH)D levels <50 nmol/L, 105 (35.8%) had levels 50–75 nmol/L and 189 (62.6%) had levels >75 nmol/L. There was no evidence that earlier vitamin D status was associated with cognitive and motor outcomes in five-year-old Ugandan children. This study adds to the sparse literature and highlights the need for further longitudinal studies on vitamin D and neurobehavioural outcomes in children living in sub-Saharan Africa.
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Arandia, Gabriela, Annette Boles, Veronica Lopez, and Volker Neugebauer. "DIABETES AS A RISK FACTOR FOR MILD COGNITIVE IMPAIRMENT IN OLDER RESIDENTS OF RURAL WEST TEXAS." Innovation in Aging 3, Supplement_1 (November 2019): S860. http://dx.doi.org/10.1093/geroni/igz038.3160.
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Abstract While a growing body of evidence suggests a link between diabetes and Alzheimer’s disease, few studies have examined the impact of diabetes on mild cognitive impairment, the precursor to Alzheimer’s disease, especially among older, rural, and ethnically diverse populations. Using data from Project FRONTIER (Facing Rural Obstacles to Healthcare Now Through Intervention, Education, & Research), a longitudinal cohort aging study in rural West Texas, the aim of this study was to compare the risk for mild cognitive impairment among participants who, according to blood sugar levels, were pre-diabetic/diabetic versus normal. This study uses baseline and 3-year follow-up data from a subsample (recruited from Cochran County) of the larger, four-county sample of Project FRONTIER. The study sample (n=206) ranged from 40 to 87 years old (mean age: 58.3 + 11.7 years old), was predominantly female (73.3%), White (88.4%), with slightly over half self-reporting as Hispanic (51.0%). Logistic regression results revealed that those who had prediabetes/diabetes had 1.81 times the risk for developing mild cognitive impairment compared to those who had normal blood sugar levels. These findings indicate the need for earlier intervention for improved diabetes prevention, self-management, and control (diet, physical activity, treatments) to help offset the development of mild cognitive impairment, which could progress to Alzheimer’s disease later in life. More research is needed to confirm the link between pre-diabetes/diabetes and mild cognitive impairment in other populations and settings.
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Ghisletta, Paolo, John J. McArdle, and Ulman Lindenberger. "Longitudinal Cognition-Survival Relations in Old and Very Old Age." European Psychologist 11, no. 3 (January 2006): 204–23. http://dx.doi.org/10.1027/1016-9040.11.3.204.
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We use a statistical model that combines longitudinal and survival analyses to estimate the influence of level and change in cognition on age at death in old and very old individuals. Data are from the Berlin Aging Study, in which an initial sample of 516 elderly individuals with an age range of 70 to 103 years was assessed up to 11 times across a period of up to 13 years. Four cognitive ability domains were assessed by two variables each: perceptual speed (Digit Letter and Identical Pictures), episodic memory (Paired Associates and Memory for Text), fluency (Categories and Word Beginnings), and verbal knowledge (Vocabulary and Spot-a-Word). Longitudinal models on cognition controlled for dementia diagnosis and retest effects, while survival models on age at death controlled for age, sex, socioeconomic status, sensory and motor performance, and broad personality characteristics. Results indicate: (1) Individual differences in the level of and in the linear change in performance are present for all cognitive variables; (2) when analyzed independently of cognitive performance, all covariates, except broad personality factors, predict survival; (3) when cognitive performance is accounted for, age, sex, and motor performance do predict survival, while socioeconomic status and broad personality factors do not, and sensory performance does only at times; (4) when cognitive variables are analyzed independently of each other, both level and change in speed and fluency, as well as level in memory and knowledge predict survival; (5) when all cognitive variables are analyzed simultaneously using a two-stage procedure, none of them is significantly associated to survival. In agreement with others, our findings suggest that survival is related to cognitive development in old and very old age in a relatively global, rather than ability-specific, manner.