Academic literature on the topic 'Cognition disorders – Diagnosis'
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Journal articles on the topic "Cognition disorders – Diagnosis"
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Trotti, Rebekah L., Sunny Abdelmageed, David A. Parker, Dean Sabatinelli, Carol A. Tamminga, Elliot S. Gershon, Sarah K. Keedy, et al. "Neural Processing of Repeated Emotional Scenes in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder." Schizophrenia Bulletin 47, no. 5 (March 6, 2021): 1473–81. http://dx.doi.org/10.1093/schbul/sbab018.
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Abstract Impaired emotional processing and cognitive functioning are common in schizophrenia, schizoaffective disorder, and bipolar disorders, causing significant socioemotional disability. While a large body of research demonstrates abnormal cognition/emotion interactions in these disorders, previous studies investigating abnormalities in the emotional scene response using event-related potentials (ERPs) have yielded mixed findings, and few studies compare findings across psychiatric diagnoses. The current study investigates the effects of emotion and repetition on ERPs in a large, well-characterized sample of participants with schizophrenia-bipolar syndromes. Two ERP components that are modulated by emotional content and scene repetition, the early posterior negativity (EPN) and late positive potential (LPP), were recorded in healthy controls and participants with schizophrenia, schizoaffective disorder, bipolar disorder with psychosis, and bipolar disorder without psychosis. Effects of emotion and repetition were compared across groups. Results displayed significant but small effects in schizophrenia and schizoaffective disorder, with diminished EPN amplitudes to neutral and novel scenes, reduced LPP amplitudes to emotional scenes, and attenuated effects of scene repetition. Despite significant findings, small effect sizes indicate that emotional scene processing is predominantly intact in these disorders. Multivariate analyses indicate that these mild ERP abnormalities are related to cognition, psychosocial functioning, and psychosis severity. This relationship suggests that impaired cognition, rather than diagnosis or mood disturbance, may underlie disrupted neural scene processing in schizophrenia-bipolar syndromes.
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Kauliņa, Anda. "Cognitive Analysis of 9 to 11-Year-Old Children With Intellectual Development Disorders." Journal of Pedagogy and Psychology "Signum Temporis" 9, no. 1 (December 20, 2017): 16–22. http://dx.doi.org/10.1515/sigtem-2017-0006.
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Abstract Cognitive development significantly influences efficiency and results of child’s understanding and comprehension of the world. Attention and cognition play a significant role to ensure academic achievement and success. Attention is essential for purposeful planning of action and systematic work. Attention is necessary to follow the study material and for physical survival in everyday life. Cognition is significant in decision making and evaluating possible outcomes, being especially important in children with cognitive development disorders. The aim of the present study was to find out the peculiarities of the cognitive processes in 9 to 11-year-old children with cognitive development disorders. Previous literature suggests that children with intellectual development disorders are at increased risk of general cognitive disorders. To test this assumption and establish cognitive abilities in children with intellectual development disorders, the following subtests of the Vienna Test System (VTS) were used: CPM/S2 (Raven's Coloured Progressive Matrices), B19 (Double Labyrinth Test) and WAFF (Perception and Attention Functions: Focused Attention). VTS is one of the leading computer-based psychophysiological testing systems in Europe. In addition to testing, behavioural observations were also carried out. Study results reveal that children with a shared diagnosis are not as similar when it comes to cognition and attention. Not all children within the sample group exhibited reduced attention and concentration, although the whole participant sample was diagnosed with intellectual development disorder. Meanwhile, risk factors hindering normal cognitive development were identified.
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Foley, J. M., M. J. Wright, A. L. Gooding, M. Ettenhofer, M. Kim, M. Choi, S. A. Castellon, et al. "Operationalization of the updated diagnostic algorithm for classifying HIV-related cognitive impairment and dementia." International Psychogeriatrics 23, no. 5 (November 19, 2010): 835–43. http://dx.doi.org/10.1017/s1041610210002085.
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ABSTRACTBackground: This study applies the updated HIV-Associated Neurocognitive Disorders (HAND) diagnostic algorithm.Methods: Participants were 210 HIV-infected-adults, classified using proposed HAND criteria: HIV-Associated Dementia (HAD), Mild Neurocognitive Disorder (MND), Asymptomatic Neurocognitive Impairment (ANI).Results: The algorithm yielded: normal = 32.8%, ANI = 21.4%, MND = 34.3%, and HAD = 11.4%. Normal participants performed superior to HAND-defined participants on cognition, and HAD participants performed more poorly on global cognition and executive functioning. Two distinct subgroups of interest emerged: (1) functional decline without cognitive impairment; (2) severe cognitive impairment and minimal functional compromise.Conclusions: The algorithm discriminates between HIV-infected cognitively impaired individuals. Diagnosis yields two unique profiles requiring further investigation. Findings largely support the algorithm's utility for diagnosing HIV-cognitive-impairment, but suggest distinct subsets of individuals with discrepant cognitive/functional performances that may not be readily apparent by conventional application of HAND diagnosis.
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Lewandowski, K. E., S. H. Sperry, B. M. Cohen, and D. Öngür. "Cognitive variability in psychotic disorders: a cross-diagnostic cluster analysis." Psychological Medicine 44, no. 15 (April 7, 2014): 3239–48. http://dx.doi.org/10.1017/s0033291714000774.
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Background.Cognitive dysfunction is a core feature of psychotic disorders; however, substantial variability exists both within and between subjects in terms of cognitive domains of dysfunction, and a clear ‘profile’ of cognitive strengths and weaknesses characteristic of any diagnosis or psychosis as a whole has not emerged. Cluster analysis provides an opportunity to group individuals using a data-driven approach rather than predetermined grouping criteria. While several studies have identified meaningful cognitive clusters in schizophrenia, no study to date has examined cognition in a cross-diagnostic sample of patients with psychotic disorders using a cluster approach. We aimed to examine cognitive variables in a sample of 167 patients with psychosis using cluster methods.Method.Subjects with schizophrenia (n = 41), schizo-affective disorder (n = 53) or bipolar disorder with psychosis (n = 73) were assessed using a battery of cognitive and clinical measures. Cognitive data were analysed using Ward's method, followed by a K-means cluster approach. Clusters were then compared on diagnosis and measures of clinical symptoms, demographic variables and community functioning.Results.A four-cluster solution was selected, including a ‘neuropsychologically normal’ cluster, a globally and significantly impaired cluster, and two clusters of mixed cognitive profiles. Clusters differed on several clinical variables; diagnoses were distributed amongst all clusters, although not evenly.Conclusions.Identification of groups of patients who share similar neurocognitive profiles may help pinpoint relevant neural abnormalities underlying these traits. Such groupings may also hasten the development of individualized treatment approaches, including cognitive remediation tailored to patients' specific cognitive profiles.
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Chen, Ruei-An, Chun-Yi Lee, Yu Lee, Chi-Fa Hung, Yu-Chi Huang, Pao-Yen Lin, Sheng-Yu Lee, and Liang-Jen Wang. "Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders." PeerJ 7 (August 1, 2019): e7432. http://dx.doi.org/10.7717/peerj.7432.
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Background Cognitive impairments in patients with depressive disorders have a negative impact on their daily skill functioning and quality of life. In this study, we evaluated the cognitive profiles and associated factors of patients with depressive disorders with the Brief Assessment of Cognition in Affective Disorders (BAC-A). Methods This cross-sectional study consisted of 75 patients with depressive disorders (56 patients with major depressive disorder (MDD) and 19 patients with depressive disorder NOS or dysthymic disorder (non-MDD)). We evaluated the participants’ cognitive functions at euthymic status using the BAC-A. The BAC-A includes six subtests derived from the Brief Assessment of Cognition in Schizophrenia (BAC-S) and Affective Processing Tests. The current severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17), and we recorded any psychotropic drugs being used by the patients. Results We observed no differences in cognitive profiles in the MDD group and non-MDD group after adjusting for educational levels, severity of depression, and psychotropic drugs. Instead, the HAMD-17 scores were negatively correlated to cognitive performance in working memory, motor speed, verbal fluency, attention and processing speed, executive function, composite score, and the six indexes of the Affective Processing Test measured by the BAC-A. A longer illness duration was associated with worse performance of four indexes of the Affective Processing Test. Furthermore, benzodiazepine use was associated with a worse performance of verbal memory, and antidepressant use was associated with better motor speed performance. Conclusion The current severity of depressive symptoms and psychotropic drugs being taken, not the diagnosis category, are associated with cognitive impairments in patients with depressive disorders. Clinicians should pay particular attention to managing residual depressive symptoms and prescribing adequate psychotropic drugs in order to eliminate depressive patients’ cognitive deficits.
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Kuklińska, Marta, Emilia J. Sitek, Bogna Brockhuis, Anna Barczak, Beata Hintze, and Ewa Narożańska. "Behavioural variant frontotemporal dementia – selected diagnostic dilemmas in neuropsychiatry." Aktualności Neurologiczne 20, no. 2 (October 30, 2020): 71–81. http://dx.doi.org/10.15557/an.2020.0010.
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Introduction: Differential diagnosis of behavioural variant frontotemporal dementia remains a challenge for neurologists and psychiatrists as some behavioural symptoms of this illness and psychiatric disorders, such as apathy, are not specific. Aim: The paper aims at presenting the differential diagnosis of behavioural variant frontotemporal dementia and primary psychiatric disorders. Discussion: Behavioural symptoms of behavioural variant frontotemporal dementia overlap with symptoms typical for primary psychiatric disorders. Psychotic symptoms, apathy and inappropriate behaviour are prominent in schizophrenia. Repetitive behaviours are typical for obsessive-compulsive disorders. Inattention and impulsivity are common in attention deficit and hyperactivity disorder. Disinhibition is typical of mania in the context of bipolar disorder. Thus, all these psychiatric diagnoses need to be considered in the differential diagnosis of behavioural variant frontotemporal dementia. This condition is associated with language deficits and more widespread executive and social cognition deficits. Also, the presence of neurological symptoms, such as oculomotor dysfunction, upper/lower motor neuron dysfunction or bradykinesia, may facilitate the diagnosis. Functional decline is observed during follow-up in behavioural variant frontotemporal dementia, but not in phenocopy syndrome. Conclusions: Differential diagnosis requires integration of behavioural and neuropsychological data with the results of neurological assessment and neuroimaging work-up. In ambiguous cases, if genetic testing is negative, only longitudinal observation can confirm the diagnosis of behavioural variant frontotemporal dementia or phenocopy syndrome.
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Pillon, B., B. Dubois, and Y. Agid. "Testing cognition may contribute to the diagnosis of movement disorders." Neurology 46, no. 2 (February 1, 1996): 329–34. http://dx.doi.org/10.1212/wnl.46.2.329.
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Vega-Rodríguez, Yuri E., Elena Garayzabal-Heinze, and Esther Moraleda-Sepúlveda. "Language Development Disorder in Fetal Alcohol Spectrum Disorders (FASD), a Case Study." Languages 5, no. 4 (October 10, 2020): 37. http://dx.doi.org/10.3390/languages5040037.
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Prenatal alcohol exposure can cause developmental damage in children. There are different types and ranges of alterations that fall under the name of fetal alcohol spectrum disorders (FASD). Disabilities in learning, cognition, and behavior are observed. Environmental conditions are an influencing factor in this population since they are generally adverse and are either not diagnosed at an early stage or given the appropriate support and approach. We present a case study of a 9-year-old child, in which all the variables affecting his development (FASD diagnosis and socioenvironmental conditions) were observed and analyzed. His early childhood under institutional care, the move to a foster home at the age of 6, and several measures of evaluation from foster care to the present are described. Difficulties in vocabulary, access to vocabulary, morphology, syntax, grammar, oral narrative, pragmatics, speech, and communication were observed, along with cognitive difficulties in memory, perception and executive functioning, social adaptation, learning, and behavior. An early diagnosis and approach enable this population to develop skills in different dimensions to address early adversity despite their neurological and behavioral commitment. Speech-language pathologist services are crucial for the diagnosis and treatment of the language and communication difficulties that characterize this syndrome.
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Ducharme, Simon, Annemiek Dols, Robert Laforce, Emma Devenney, Fiona Kumfor, Jan van den Stock, Caroline Dallaire-Théroux, et al. "Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders." Brain 143, no. 6 (March 4, 2020): 1632–50. http://dx.doi.org/10.1093/brain/awaa018.
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Abstract The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-onset dementia. The diagnosis of bvFTD remains challenging because of the limited accuracy of neuroimaging in the early disease stages and the absence of molecular biomarkers, and therefore relies predominantly on clinical assessment. BvFTD shows significant symptomatic overlap with non-degenerative primary psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders and even personality disorders. To date, ∼50% of patients with bvFTD receive a prior psychiatric diagnosis, and average diagnostic delay is up to 5–6 years from symptom onset. It is also not uncommon for patients with primary psychiatric disorders to be wrongly diagnosed with bvFTD. The Neuropsychiatric International Consortium for Frontotemporal Dementia was recently established to determine the current best clinical practice and set up an international collaboration to share a common dataset for future research. The goal of the present paper was to review the existing literature on the diagnosis of bvFTD and its differential diagnosis with primary psychiatric disorders to provide consensus recommendations on the clinical assessment. A systematic literature search with a narrative review was performed to determine all bvFTD-related diagnostic evidence for the following topics: bvFTD history taking, psychiatric assessment, clinical scales, physical and neurological examination, bedside cognitive tests, neuropsychological assessment, social cognition, structural neuroimaging, functional neuroimaging, CSF and genetic testing. For each topic, responsible team members proposed a set of minimal requirements, optimal clinical recommendations, and tools requiring further research or those that should be developed. Recommendations were listed if they reached a ≥ 85% expert consensus based on an online survey among all consortium participants. New recommendations include performing at least one formal social cognition test in the standard neuropsychological battery for bvFTD. We emphasize the importance of 3D-T1 brain MRI with a standardized review protocol including validated visual atrophy rating scales, and to consider volumetric analyses if available. We clarify the role of 18F-fluorodeoxyglucose PET for the exclusion of bvFTD when normal, whereas non-specific regional metabolism abnormalities should not be over-interpreted in the case of a psychiatric differential diagnosis. We highlight the potential role of serum or CSF neurofilament light chain to differentiate bvFTD from primary psychiatric disorders. Finally, based on the increasing literature and clinical experience, the consortium determined that screening for C9orf72 mutation should be performed in all possible/probable bvFTD cases or suspected cases with strong psychiatric features.
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Korostil, M., and A. Feinstein. "Anxiety disorders and their clinical correlates in multiple sclerosis patients." Multiple Sclerosis Journal 13, no. 1 (January 2007): 67–72. http://dx.doi.org/10.1177/1352458506071161.
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Objective To assess prevalence rates and clinical correlates of anxiety disorders in patients with multiple sclerosis (MS). Methods Demographic and neurological data were collected on 140 consecutive clinic attendees, and their lifetime and point prevalences of anxiety disorders were determined with the Structured Clinical Interview for DSM-IV disorders (SCID-IV). All subjects completed the self-report Hospital Anxiety and Depression Scale (HADS). Suicidal intent was rated with the Beck Suicide Scale (BSS), psychosocial stressors and supports were quantified with Social Stress and Support Interview (SSSI), and cognition assessed with Neuropsychological Screening Battery for MS. Results The lifetime prevalence of any anxiety disorder was 35.7%, with panic disorder (10%), obsessive compulsive disorder (8.6%), and generalized anxiety disorder (18.6%), the most common diagnoses obtained. Subjects with an anxiety disorder were more likely to be female, have a history of depression, drink to excess, report higher social stress and have contemplated suicide. The diagnosis of an anxiety disorder had been missed in the majority of subjects, therefore, they had not received treatment. A discriminant function analysis identified a series of variables that correctly classified 75% of patients with an anxiety disorder. Conclusion Anxiety disorders are common in patients with MS, but are frequently overlooked and under-treated. Risk factors include being female, a co-morbid diagnosis of depression, and limited social support. Clinicians should evaluate all MS subjects for anxiety disorders, as they represent a treatable cause of disability in MS.
Dissertations / Theses on the topic "Cognition disorders – Diagnosis"
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李穎 and W. Lee. "Subjective cognitive impairments in Schizophrenia and related disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31384948.
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Clarnette, Roger M. "Predictors of cognitive decline in those with subjective memory complaint." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0245.
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[Truncated abstract] Background: Dementia, largely due to Alzheimer's disease (AD), is a major public health problem. The early identification of disease is an important challenge for clinicians because treatment of AD is now available. A simple and accurate means of stratifying risk for AD and identifying early disease is needed so that risk factor modification and treatment can occur optimally. To date, despite many attempts, an accurate means of standardising an approach to the assessment of subtle cognitive symptoms has not been developed. A subjective complaint of poor memory has been identified as a possible marker for underlying brain disease. This study examines the utility of neuropsychological scores, homocysteine levels, APOE genotyping and brain imaging as predictors of cognitive decline in individuals with subjective memory complaint (SMC). Method Eighty subjects with SMC were recruited from memory clinics and the community (MC: 1). Forty-two control subjects were also examined (MC: 0). CAMDEX was used to describe baseline clinical features. The CAMCOG was used as a global test of cognition and was administered annually for four years. At baseline, neuropsychological testing was administered. Cranial CT scanning, measurement of plasma homocysteine and APOE genotyping were completed. Categorical variables were analysed using chi-square according to Pearson's method. Continuous data was analysed using Student's t-tests and Mann-Whitney tests. A logistic regression model was used to identify independent contributors to the presence of memory complaint. Participants were then matched for age, gender and time to follow-up (up for three years) to determine longitudinal predictors of cognitive decline. ... Baseline CAMCOG scores were greater in the control group (MC:0 = 98.3 ? 2.8, MC:1 94.2 ? 5.5, Z ?4.46, p 0.000). There were no differences in neuropsychological scores, concentration of total plasma homocysteine, APOE genotype or brain scan measurements. Using the Wald stepwise selection method, logistic regression could not be established due to non-convergence regardless of whether or not the continuous variables were re-coded into dichotomous variables. A matching process that created 32 pairs of controls/subjects allowed follow-up analysis. The controls showed significant improvement with time on the CAMCOG unlike subjects (mean ? SD, controls 1.5 ?-3.0, Z - 2.61, p 0.01, subjects 0.2 ? 3.2, Z ? 0.24, p 0.81). The logistic regression analysis showed that group membership could not be defined by any single independent variable. When group membership was abandoned and those with stable scores were compared to those who declined no clear meaningful independent predictors of decline apart from age were identified. Conclusions: Methodological issues such as small sample size and inadequate follow up duration were identified that may have precluded identification of predictive factors for cognitive decline. The results indicate that complaints of memory problems are not associated with established risk factors for Alzheimer's disease and fail to predict objective cognitive decline over three years. Future studies should continue trying to identify robust predictors of cognitive decline in later life.
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Tarantello, Concetta. "The role of subjective memory complaints in predicting cognitive impairment associated with future Alzheimer’s disease: a community based study." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/6190.
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In recent years there has been a substantial increase in research examining the role of subjective memory complaints (SMC) in cognitive function and Alzheimer’s disease. These studies have related SMC to many different cognitive outcomes, such as retaining normal cognitive function, a fluctuating cognitive performance and the development of Alzheimer’s disease. Most of these studies have focused on older populations and have employed a limited assessment of cognitive function. This limits the available evidence regarding the clinical utility of SMC. The literature on the role of SMC in younger subjects is scarce. It is not known whether memory complaints are useful in predicting future cases of Alzheimer’s disease in younger community-based subjects. Aims: The main aim of the present study was to determine whether SMC predict the development of cognitive impairment in a younger cohort of subjects, many of whom were under the age of 70 years (73%), based on their risk profile and neuropsychological assessment. A further aim was to ascertain whether the DRS or 7MS are sensitive screening tools for MCI and examine whether the presence of SMC affects the 3-year cognitive outcome of subjects. To address these aims, this study consisted of two parts: a cross-sectional design and a longitudinal follow-up component. Methods: This study was carried out with 86 community-dwelling subjects recruited via advertisement within the catchment area of Central Sydney Area Health Service. The mean age of the subjects was 63.1 years (SD=8.4). Subjective memory complaints were assessed using a single question. Cognitive function was assessed using a comprehensive battery of tests, selected on the basis of their sensitivity to identifying cognitive impairment typically associated with Alzheimer’s disease. After the initial analysis between those with SMC and without SMC, subjects were further classified according to their performance on an episodic memory task (i.e., delayed verbal recall, Rey, 1964) as having normal memory function, SMC or aMCI. Results: Part 1 - Subjective memory complaints (SMC) were reported by 63% of the sample. The initial analysis between subjects with SMC (n=54) and without SMC (n=32) suggested an initial relationship between SMC and cognitive functioning. Subjects with SMC had impaired global cognitive functioning on two brief screening tests (7MS and DRS), working memory, verbal recall and visuomotor speed. However, subsequent screening with the delayed verbal recall test showed that 12 of the 54 subjects with SMC demonstrated significant cognitive impairment, scoring 2 SD below the control group mean. After these subjects were removed to form the aMCI group, the cognitive differences between subjects with SMC and without SMC were no longer apparent. Subjects with aMCI showed evidence of multiple cognitive deficits (below 1 SD of control group mean) with a high percentage of subjects demonstrating impairment on tests of verbal learning, verbal recall, verbal ability and visuomotor speed. Further analysis showed a significant association between age and subjects identified as having SMC (r=-.581, p<.001) and aMCI (r=.692, p<.001). From the age of 60 onwards, both the SMC and aMCI groups demonstrated a more rapid cognitive decline with increasing age in several cognitive domains. Part 2 - After a mean interval of 3.2 years, 43 subjects were followed up. Subjects with aMCI showed evidence of greater decline on both screening tests (7MS; DRS), whilst the SMC group had significantly higher scores. This trend was also apparent with other neuropsychological testing. The analysis of change over time in cognitive function showed that the majority of subjects (both SMC aMCI) either remained stable or improved their cognitive performance. It is likely that the small sample size and short follow-up interval of the present study contributed to the present observation of no change in cognitive function over time. Discussion: The present findings suggest that subjective memory complaints are a poor predictor of cognitive function. In isolation, SMC are unlikely to be useful for identifying cases with significant cognitive impairment. This is particularly relevant for subjects under the age of 70 years. However, for subjects over the age of 70 years, SMC are likely to identify significant cases with neuropsychological assessment (such as animal fluency and delayed recall). Conclusion: The present study showed that SMC are a poor predictor of cognitive function in subjects under the age of 70 years. This study provided evidence that selected and relatively quick to administer formal neuropsychological tests of cognitive function (in particular tests of animal fluency and delayed recall) are better able to identify those at risk of developing cognitive impairment associated with Alzheimer’s disease, at an earlier age. This would thus allow exposure to earlier treatment options, such as donepezil, aricept, vitamin E, and memantine”.
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Tarantello, Concetta. "The role of subjective memory complaints in predicting cognitive impairment associated with future Alzheimer’s disease: a community based study." University of Sydney, 2009. http://hdl.handle.net/2123/6190.
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Doctor of Philosophy(PhD)In recent years there has been a substantial increase in research examining the role of subjective memory complaints (SMC) in cognitive function and Alzheimer’s disease. These studies have related SMC to many different cognitive outcomes, such as retaining normal cognitive function, a fluctuating cognitive performance and the development of Alzheimer’s disease. Most of these studies have focused on older populations and have employed a limited assessment of cognitive function. This limits the available evidence regarding the clinical utility of SMC. The literature on the role of SMC in younger subjects is scarce. It is not known whether memory complaints are useful in predicting future cases of Alzheimer’s disease in younger community-based subjects. Aims: The main aim of the present study was to determine whether SMC predict the development of cognitive impairment in a younger cohort of subjects, many of whom were under the age of 70 years (73%), based on their risk profile and neuropsychological assessment. A further aim was to ascertain whether the DRS or 7MS are sensitive screening tools for MCI and examine whether the presence of SMC affects the 3-year cognitive outcome of subjects. To address these aims, this study consisted of two parts: a cross-sectional design and a longitudinal follow-up component. Methods: This study was carried out with 86 community-dwelling subjects recruited via advertisement within the catchment area of Central Sydney Area Health Service. The mean age of the subjects was 63.1 years (SD=8.4). Subjective memory complaints were assessed using a single question. Cognitive function was assessed using a comprehensive battery of tests, selected on the basis of their sensitivity to identifying cognitive impairment typically associated with Alzheimer’s disease. After the initial analysis between those with SMC and without SMC, subjects were further classified according to their performance on an episodic memory task (i.e., delayed verbal recall, Rey, 1964) as having normal memory function, SMC or aMCI. Results: Part 1 - Subjective memory complaints (SMC) were reported by 63% of the sample. The initial analysis between subjects with SMC (n=54) and without SMC (n=32) suggested an initial relationship between SMC and cognitive functioning. Subjects with SMC had impaired global cognitive functioning on two brief screening tests (7MS and DRS), working memory, verbal recall and visuomotor speed. However, subsequent screening with the delayed verbal recall test showed that 12 of the 54 subjects with SMC demonstrated significant cognitive impairment, scoring 2 SD below the control group mean. After these subjects were removed to form the aMCI group, the cognitive differences between subjects with SMC and without SMC were no longer apparent. Subjects with aMCI showed evidence of multiple cognitive deficits (below 1 SD of control group mean) with a high percentage of subjects demonstrating impairment on tests of verbal learning, verbal recall, verbal ability and visuomotor speed. Further analysis showed a significant association between age and subjects identified as having SMC (r=-.581, p<.001) and aMCI (r=.692, p<.001). From the age of 60 onwards, both the SMC and aMCI groups demonstrated a more rapid cognitive decline with increasing age in several cognitive domains. Part 2 - After a mean interval of 3.2 years, 43 subjects were followed up. Subjects with aMCI showed evidence of greater decline on both screening tests (7MS; DRS), whilst the SMC group had significantly higher scores. This trend was also apparent with other neuropsychological testing. The analysis of change over time in cognitive function showed that the majority of subjects (both SMC aMCI) either remained stable or improved their cognitive performance. It is likely that the small sample size and short follow-up interval of the present study contributed to the present observation of no change in cognitive function over time. Discussion: The present findings suggest that subjective memory complaints are a poor predictor of cognitive function. In isolation, SMC are unlikely to be useful for identifying cases with significant cognitive impairment. This is particularly relevant for subjects under the age of 70 years. However, for subjects over the age of 70 years, SMC are likely to identify significant cases with neuropsychological assessment (such as animal fluency and delayed recall). Conclusion: The present study showed that SMC are a poor predictor of cognitive function in subjects under the age of 70 years. This study provided evidence that selected and relatively quick to administer formal neuropsychological tests of cognitive function (in particular tests of animal fluency and delayed recall) are better able to identify those at risk of developing cognitive impairment associated with Alzheimer’s disease, at an earlier age. This would thus allow exposure to earlier treatment options, such as donepezil, aricept, vitamin E, and memantine”.
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Huang, Chaorui. "Mild cognitive impairment : neuroimaging markers for early diagnosis of dementia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-633-2/.
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Wasielewski, Sean. "Discrimination of brain-damaged, depressed, and normal subjects using the Woodcock-Johnson tests of cognitive ability-revised." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1117101.
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The purpose of this investigation was to examine the validity of the Woodcock Johnson Tests of Cognitive Ability-Revised (WJTCA-R) in discriminating between individuals with neurological or psychiatric impairments and those without known impairment. The primary question was whether WJTCA-R Standard Battery test scores significantly differentiated between individuals with brain-damage (n = 36), depression (n = 21), and without known impairments (n = 32). Archival data obtained for the development of a new neuropsychological assessment measure utilizing the WJTCA-R was analyzed. The results of a discriminant functions analysis indicated that significant differences between the groups existed on the WJTCA-R. Based on WJTCA-R Standard Battery performance alone, participants had a 53% chance of being correctly classified into their diagnostic group. Brain-damaged individuals had the best chance of being correctly classified while correct classification of depressed individuals was only slightly greater than that obtained from random assignment. In addition to moderately supporting the use of a multi-factored, theory-driven assessment instrument, the results of this study have clinical relevance for the development of diagnosis-specific recommendations for brain-damaged and depressed individuals.Department of Educational Psychology
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Harrison, Benjamin James, and habj@unimelb edu au. "Functional imaging studies of executive-attention in humans comparing healthy subjects & patients with neuropsychiatric disorders." Swinburne University of Technology, 2006. http://adt.lib.swin.edu.au./public/adt-VSWT20060227.101116.
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One of the major goals of cognitive neuroscience is to better understand the psychological and
neural bases of human executive-attention. Executive or supervisory attention refers to a collection
of higher-order cognitive functions whose primary contribution to behavior is to support controlled
information processing and action. The capacity to control attention is essential for our adaptive
interaction with the environment because it allows flexibility in our responses to ever changing
situational contexts and demands. Executive-attention processes therefore play a unique role in
shaping the human experience.
Use of three-dimensional functional neuroimaging has fast become the empirical standard for
investigating how executive-attention is implemented in the human brain. Most recently, emphasis
has been placed on the use of these techniques to parse discrete components of a putative neural
network relating to action-monitoring and cognitive control processes of the medial and lateral
prefrontal cortex. This work has relied heavily on the use of popular experimental paradigms such
as the Stroop task and their unique capacity to challenge such processes in humans. These tasks
have also been especially useful for conceptualizing the nature of higher-cognitive dysfunction in
complex brain disorders such as schizophrenia.
The focus of this thesis concerns a novel application of the Stroop paradigm and functional imaging
approach to examine executive-attention performance in healthy subjects and patients with
schizophrenia and obsessive-compulsive disorder. On one hand, this work aimed to address
current ideas on the nature of executive-control mechanisms and how they may be compromised in
these two common psychiatric disorders. On the other hand, this work aimed to examine important
conceptual and methodological issues associated with functional imaging approaches to the study
of higher-cognition and cognitive psychopathology in humans.
In line with connectionist models of executive-attention phenomena, the first study in this thesis
investigated the effects of task practice on a larger-scale neurocognitive network associated with
performance of the Stroop task in healthy subjects. This study involved the use of a novel methodological approach to model physiological covariances or ?functional connectivity? in PET
data, which generated previously unseen and interesting insights into the neural basis of Stroop
phenomena, whilst complimenting existing ideas on the role of the anterior cingulate and lateral
prefrontal cortex in mediating executive-control functions. These findings were then extended to a
comparative study of patients with schizophrenia and obsessive-compulsive disorder. This study
largely corroborated previous reports of prefrontal executive dysfunction in schizophrenia,
although patients also showed evidence for a compensatory strengthening of connectivity in a
fronto-parietal network that accompanied task practice. This finding has important implications for
existing models of higher-cognitive dysfunction and abnormal brain integration in schizophrenia.
For patients with OCD compared to healthy subjects, performance of the Stroop task evoked a
pattern of abnormal connectivity among predominantly corticostriatal regions, including a
previously reported hyperfunction of the dorsal anterior cingulate cortex. While this latter result
has been linked to a specific disturbance of action-monitoring in patients with OCD, the current
study suggests that this may map onto a more extensive corticostriatal network abnormality in line
with current theoretical models of this illness.
One caveat raised in the first study of patients with schizophrenia concerned the effects of illnesschronicity
and medication on functional imaging studies of higher-cognition and prefrontal
function in schizophrenia. To address this, a second clinical study was undertaken in patients with
a first-episode of schizophrenia (diagnosis confirmed at follow-up) who were examined before and
after commencing antipsychotic treatment. Overall, the findings from this study support the idea of
trait-like disturbances of prefrontal executive function in schizophrenia; however, they also
suggested that aspects of this disturbance may be specific to the critical, early stage of illness -
implicating progressive changes with illness chronicity and/or treatment intervention. These
findings are discussed in relation to the developmental context of cognitive psychopathology in
schizophrenia.
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Aubin, Ginette. "Daily activities in people with schizophrenia : relationships with cognition and community functioning." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115848.
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While most people with schizophrenia face the functional consequences of a lifelong disorder, very few studies have investigated the specific domain of daily living activities performance. The purpose of this thesis was to examine the relationships between daily activity performance, cognitive deficits, and community functioning in people with schizophrenia. More specifically, the objectives were: 1) to describe functional limitations during daily task performance, 2) to explore the existence of subgroups of participants with similar functional limitations profiles, 3) to explore the relationships between daily task performance and cognitive functions as well as 4) with community functioning. This thesis tested the hypothesis that limitations in task performance negatively influence community functioning.A sample of 82 individuals with schizophrenia and 28 healthy controls participated in this study and were assessed during a meal preparation task with the Perceive, Recall, Plan and Perform (PRPP) System of Task Analysis and on cognitive tests of visuospatial memory, spatial working memory, visuomotor coordination, planning and selective attention. Community functioning was assessed with the Independent living Skills Survey and the Multnomah Community Ability Scale. Limitations in the Perceive, Recall and Plan quadrants of the PRPP System, were found in participants with schizophrenia when compared to a control group (n = 28), as well as in the complete sample (n = 82). Participants in the high-efficiency subgroup ( n =36) were more independent in daily living and performed better on the visuospatial associative learning task than the low-efficiency subgroup (n = 46). At the specific level of individual profiles, participants were distributed along a continuum of low- to high-functioning on the PRPP System factors and on functional, cognitive, and clinical characteristics.
The associative learning task was most associated with task performance, along with working memory and planning. Finally, less efficient planning skills were associated with a lower level of community functioning, confirming the hypothesis. These results emphasize the relationship of associative visual memory to daily task performance, as well as that of efficiency in daily activities for residential status. Integrating these findings into the rehabilitation process will contribute to better meeting the needs of people with schizophrenia.
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李永浩 and Wing-ho Peter Lee. "Information processing deficits and outcome patterns in schizophrenic patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31231858.
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Harris, Rebekah Lynn. "Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9774/.
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Diabetes is a disease with a deleterious pathology that currently impacts 4.5 million individuals within the United States. This study examined the ability of a specific neuropsychological battery to identify and classify dementia type, investigated the impact of diabetes on cognition and analyzed the ability of the memory measures of the 7 Minute Screen (7MS) and the Rey-Osterrieth Recall to correctly categorize dementia type when not used in combination with a full battery. The battery in addition to exhaustive patient history, medical chart review and pertinent tests were used in initial diagnosis. Results indicated the battery was sufficient in the identification and classification of dementia type. Within the sample, diabetes did not appear to significantly impact overall battery results whereby only two measures were minimally affected by diabetes. Finally, the memory measures of the 7MS and the Rey-Osterrieth Recall were sufficient to predict membership into the Alzheimer's (AD) and vascular dementia (VD) groups with 86.4% accuracy. The classification percentage dropped to 68.3% with addition of the mild cognitive impairment category. The full battery correctly classified AD and VD dementia 87.5% and appeared to be the most robust.
Books on the topic "Cognition disorders – Diagnosis"
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Lahera, Guillermo, Paloma García-Ramo, and Salvador Ruiz-Murugarren. Social cognition in bipolar disorder. New York: Nova Science Publishers, 2012.
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Folstein, Marshal F. Mini-mental state examination: Clinical guide. Lutz, FL: Psychological Assessment Resources, 2002.
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Cognitive assessment for clinicians. 2nd ed. Oxford: Oxford University Press, 2007.
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Cognitive assessment for clinicians. Oxford: Oxford University Press, 1994.
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Burns, Jeffrey M. Early diagnosis and treatment of mild cognitive impairment. Chichester, West Sussex: John Wiley & Sons, 2008.
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Burns, Jeffrey M. Early diagnosis and treatment of mild cognitive impairment. Chichester, West Sussex: John Wiley & Sons, 2008.
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P, Tsai James, ed. Leading-edge cognitive disorders research. New York: Nova Science Publishers, 2008.
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Burns, Jeffrey M. Mild cognitive impairment and early Alzheimer's disease: Detections and diagnosis. Chichester, England: John Wiley & Sons, 2008.
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L, Landow Melanie, ed. Cognitive impairment: Causes, diagnosis, and treatments. Hauppauge, N.Y: Nova Science Publishers, 2009.
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1949-, Miller Bruce L., and Boeve Bradley F, eds. The behavioral neurology of dementia. Cambridge: Cambridge University Press, 2009.
Find full textBook chapters on the topic "Cognition disorders – Diagnosis"
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Nichelli, Paolo, and Anna Magherini. "Role of Visuospatial Cognition Assessment in the Diagnosis and Research of Atypical Parkinsonian Disorders." In Atypical Parkinsonian Disorders, 213–33. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-834-x:213.
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Robichaud, Melisa, Naomi Koerner, and Michel J. Dugas. "Diagnosis and Assessment." In Cognitive Behavioral Treatment for Generalized Anxiety Disorder, 43–75. Second edition. | New York, NY : Routledge, 2019. | Revision of: Cognitive behavioral treatment for generalized anxiety disorder / Michel J. Dugas, Melisa Robichaud.: Routledge, 2019. http://dx.doi.org/10.4324/9781315709741-3.
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Thoma, Patrizia. "Diagnostics and Therapy of Cognitive Disorders." In essentials, 27–33. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-36400-7_6.
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Ng, Yi Shiau, Nichola Z. Lax, Laurence A. Bindoff, and Doug M. Turnbull. "Mitochondrial Neurodegenerative Disorders I: Parkinsonism and Cognitive Deficits." In Diagnosis and Management of Mitochondrial Disorders, 223–39. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-05517-2_14.
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Larner, A. J. "Diagnosis (2): Disorders Causing Dementia and Cognitive Impairment." In Dementia in Clinical Practice: A Neurological Perspective, 279–96. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75259-4_9.
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McLean, Peter D., and Sheila R. Woody. "The Nature of Anxiety." In Anxiety Disorders in Adults, 26–47. Oxford University Press, 2001. http://dx.doi.org/10.1093/med:psych/9780195116250.003.0002.
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This chapter explores the extent of current knowledge on the general nature of anxiety. It begins with a discussion of categorical and dimensional views of anxiety, including issues of diagnosis, subtyping, and comorbidity. It reviews research findings into the presence of a negative affect common to anxiety states, and cognitive factors that distinguish anxiety syndromes, as well as a hierarchical model of anxiety that incorporates information from both perspectives. Finally, results from research examining distinct components of the anxiety response (behavior, cognition, and physiology) are outlined.
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Alici, Yesne, Soenke Boettger, and William S. Breitbart. "Delirium and Cognitive Impairment." In Psycho-Oncology in Palliative and End of Life Care, 94—C5.P124. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/med/9780197615935.003.0005.
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Abstract Cognitive syndromes are prevalent in palliative care settings. Delirium is the most common and often serious neuropsychiatric disorder found in palliative care settings. Delirium is characterized by abrupt onset, fluctuating disturbance in awareness, attention, cognition, and perception. Delirium is associated with increased morbidity and mortality, causing distress in patients, family members, and staff. Delirium is often underrecognized or misdiagnosed and inappropriately treated or untreated. Clinicians who care for patients with advanced cancer and at the end-of-life must be able to diagnose delirium accurately, undertake appropriate assessment of etiologies, and understand the benefits and risks of pharmacologic and nonpharmacologic interventions currently available. Dementia and other neurocognitive disorders can also be encountered in palliative care settings, have multifactorial etiologies ranging from cancer-treatments to brain metastases, and include neurodegenerative illnesses comorbidly, especially in the oldest old patient population. This chapter presents an overview of the assessment and management of delirium in cancer patients in palliative care settings. Other cognitive syndromes will be briefly described with a focus on the assessment and differential diagnosis. Professional issues, including communication challenges, ethical dilemmas, legal requirements, and service development agendas will be considered.
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Prasad, Barre Vijaya, Sumit Kumar, and Shazia W. Ali. "Foundations of Neuropsychology." In Examining Biological Foundations of Human Behavior, 94–121. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2860-0.ch007.
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Neuropsychology is one of the branches in neuroscience (or sub-branch of psychology) that seeks to understand the brain structure and further relates it with specific human behavior and psychological processes. Neuropsychology's central aim is to understand how the brain produces behavior, mental processes, and cognition and then applies it for diagnosis and treatment of different behavioral and cognitive defects in various neurological disorders. Neuropsychology is a field that draws information and material from neurology, cognitive psychology, and psychiatry and also act as a junction point for investigators belonging to related disciplines. Its central aim is to understand how brain functioning influences behavior and cognition. Further, the chapter discusses the relationship between structure and function of the brain, the rise of neuropsychology as a distinct discipline, logic of cerebral organization, and localization and lateralization of functions. Finally, the authors had also explain the approaches and methodologies of clinical and cognitive neuropsychologists.
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Sugiura, Motoaki. "A Cognitive Neuroscience Approach to Self and Mental Health." In Advances in Bioinformatics and Biomedical Engineering, 1–10. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2113-8.ch001.
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Elucidating the neural mechanisms underlying cognitive processes related to self has been a promising approach to enhancing the scientific knowledge of mental health and mental disorders. However, relevant data from functional neuroimaging studies have not yet converged. The multi-layered model of self-processing proposed here reconciles these seemingly controversial findings by assuming there are three layers of self, including the physical self, interpersonal relationships, and social value. A schema that associates the representations of output and feedback in different cortical networks was conceptualized for each layer of self. The concepts of self-related cognition and mental disorders may be reconstructed based on this three-layer structure. The brain regions that accommodate the proposed schema are assumed to respond during the detection of error relative to a prediction; consequently, this neural response may be used for diagnosis and evaluation of mental disorders and health.
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Zanarini, Mary C. "History of the Borderline Diagnosis." In In the Fullness of Time, 1–6. Oxford University Press, 2018. http://dx.doi.org/10.1093/med-psych/9780195370607.003.0001.
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The borderline diagnosis was first described by Alfred Stern in 1938. However, “borderline personality disorder” (BPD) did not enter the official nomenclature of American psychiatry until 1980. Between these two time points, psychoanalysts and psychiatrists carefully described aspects of borderline psychopathology, particularly cognitive symptoms. Two of the most careful and influential descriptions of the borderline diagnosis in the 1960s and 1970s were those of Otto Kernberg, who described the broad concept of borderline personality organization (BPO), and John Gunderson, who described the affective, cognitive, impulsive, and interpersonal symptoms of BPD. After 1980, BPD was often described as being a subthreshold variant of various diagnostic spectrums (e.g., mood disorders, impulsive disorders, trauma disorders) that were in vogue at that time. However, BPD is now commonly accepted as a well-validated disorder with a characteristic symptom profile that distinguishes it from other disorders, including other personality disorders.
Conference papers on the topic "Cognition disorders – Diagnosis"
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Almeida, Mariana, Paulo Caramelli, Maira Barbosa, Ana Paula Santos, and Karolina Carmona. "ALCOHOL CONSUMPTION AND COGNITIVE AND FUNCTIONAL PERFORMANCE IN OLDER ADULTS AGED 75+ YEARS: THE PIETÀ STUDY." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda034.
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Introduction: The relationship between alcohol and cognition is complex. Objective: To investigate the association of alcohol consumption with cognitive impairment, functionality, psychiatric and neurological diagnoses. Methods: Cross-sectional population-based study. 602 subjects 75+ years were categorized according to the number of drinks consumed per week: 0 (abstainers); 0.1 to 7 (light); 7.1 to 14 (moderate); > 14 (heavy). Cognitive diagnoses were established: dementia, cognitive impairment no dementia (CIND) and without cognitive impairment. Results: On multivariate analysis there was no association between cognitive profile and current or previous alcohol consumption. When previous alcohol consumption was treated as dichotomous variable, no association emerged with cognitive profile (p=0.109). As for current habit of alcohol intake treated as dichotomous variable, the absence of alcohol consumption was associated with dementia (OR=2.34; 95%CI: 1.39- 3.90), stroke (p=0.014), current major depression (p=0.013), parkinsonism (p=0.041) and worse functionality (p=0.001). Cachaça consumption was associated with dementia (OR=2.52; 95%CI: 1.25-5.04). Conclusion: Absence of current alcohol consumption was associated with diagnosis of dementia, stroke, major depression, parkinsonism and worse functionality. On the other hand, intake of cachaça was associated with dementia.
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Rabbani, Naila, and Paul John Thornalley. "Blood Biomarkers associated with Autism Spectrum Disorder may Provide Early Diagnosis." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0151.
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Autism spectrum disorders (ASD) are a collection of neuropsychiatric disorders. ASD affects 1 in 87 in Qatar and is expected to increase. The high variability and heterogeneity of the symptoms makes diagnosis of ASD difficult and uncertain, particularly at the early stages of development. If detected early, clinical support can be given to promote optimal development and well-being of children with ASD and even achieve complete remission. The current method of diagnosing ASD is by observations and interviews made by experts in child development to assess child behavior, communication and cognition: the ADOS test. There is often delay in referral for expert diagnosis; delay is typically >18 months in Qatar and >4 years in EU and USA. The diagnostic accuracy is 60 – 70%. Mutations in proteins transporters of amino acids have been linked to some cases of ASD. We hypothesized that levels of amino acids in blood, including amino acids damaged by modification by sugars (glycation), oxidation and nitration may provide novel biomarker for diagnosis of ASD at very young age.
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Baptista, Maria Alice, Nathália Kimura, Isabel Lacerda, Felipe Silva, and Marcia Cristina Dourado. "YOUNG AND LATE ONSET DEMENTIA: HOW DO THEY DIFFER IN TERMS OF DOMAINS OF AWARENESS?" In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda042.
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Background: Young onset dementia (YOD) is a diagnosis given when the neurocognitive process sets in before 65 years age. The YOD dementia process poses specific challenges related to financial issues, work and social demands, marriage, and parenthood, including losses and shifting roles, care responsibilities, as well as prospects for the future. Those challenges might account for the difference in awareness between YOD and late onset dementia (LOD). Awareness can be defined as the recognition of changes caused by deficits related to the disease process, which may include the ability to recognize a specific deficit, the emotional response to the difficulties presented and the ability to understand the impact of the disease in activities of daily living Objectives: This study is designed to investigate differences in awareness of cognitive functioning and health condition, functional activity impairments, emotional state, and social functioning and relationships among people with young onset (YOD) and late onset dementia (LOD); and examine associations between awareness and its domains with cognition, functionality, neuropsychiatric symptoms, social and emotional functioning and quality of life (QoL) in both groups. Methods: This is a cross-sectional design study. A group of 136 people with dementia and their respective caregivers (YOD = 50 and LOD = 86) were consecutively selected from an Alzheimer’s disease outpatient unit in Rio de Janeiro, Brazil. We assessed awareness of disease, dementia severity, cognition, functionality, neuropsychiatric symptoms, social and emotional functioning, and quality of life. Results: People with YOD were more aware of disease (total score), more aware of their cognitive functioning and health condition and of their functional activity impairments than people with LOD, even if this group was more severely cognitive impaired and had a worse level of functionality than LOD group. Besides, people with YOD had more neuropsychiatric symptoms than people with LOD. Multivariate linear regressions showed that functionality has a wide relationship to awareness for people with YOD. While neuropsychiatric symptoms and quality of life has a greater relation to awareness for people with LOD. Conclusions Different clinical variables are associated to different domains in YOD and LOD groups, reinforcing the heterogeneity of awareness in dementia.
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Innocencio, Giovanna de Camargo, Juliana de Souza Rosa, Patrick de Abreu Cunha Lopes, Paulo Roberto Hernandes Júnior, and Jhoney Francieis Feitosa. "Clinical overview and therapeutic management of the cognitive and behavorial aspects of Huntington’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.177.
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Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease classified among chorea that, in addition to motor symptoms, is characterized by neuropsychiatric disorders. Objectives: to analyze the cognitive and behavioral clinical aspects of Huntington’s disease and the therapeutic management of these symptoms. Methods: a literature review was carried out from the Scielo and PubMed database, using “Huntington’s disease”, “Cognition”, “Behavior” and “Treatment” as descriptors, where 11 articles were selected between 2001 and 2018. Results: the nature of cognitive and behavioral symptoms in HD are very dynamic, and cognitive dysfunctions are present prior to diagnosis. The most common clinical challenges include executive dysfunction, mainly slow thinking and attention disorders, apathy, depression and irritability. One study used data from the European Huntington’s Disease Network and evaluated almost 2.000 carriers of the mutation, in which 47.4% reported apathy, while depression and irritability occurred in 42.1%, and aggression and psychosis occurred in 38.6%. Other studies have confirmed apathy as an early manifestation related to its progression. For the therapeutic management of chorea, tetrabenazine is used, while antidepressants can be effective in mood symptoms. On the other hand, antipsychotics can lead to the advance and rapid progress of the disease. Small controlled studies with atomoxetine, donepezil and rivastigmine have found no positive effects on patients’ cognition. Recent publications have shown that circulating levels of brain-derived neutrotrophic factors in HD correlate with mood, cognition and motor function and can serve as markers of treatment success, while growth factor I is associated with cognitive decline and can provide biomarker targets for treatment validation. Conclusion: cognitive and behavioral symptoms in HD are very diversified and some strategies may have potential therapies and/or deleterious ones.
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Senna, Priscylla de, Wyllians Borelli, Wagner Brum, Eduardo Zimmer, Márcia Chaves, Arthur Schuh, and Raphael Castilhos. "FUNCTIONAL COGNITIVE DISORDER AS THE MOST FREQUENT DIAGNOSIS IN PUBLIC MEMORY CLINIC." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda059.
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Background: Functional cognitive disorder (FCD) has been described as a blind spot of dementia care. Objectives: Identify the frequency of FCD in a tertiary memory clinic (TMC). Methods: A retrospective analysis was conducted to identify new referrals from the primary care setting to a TMC from southern Brazil over 2014 to 2020. Diagnostic protocol included neurologic evaluation, cognitive screening, neuroimaging and laboratory testing. FCD was defined as cognitive complaints without objective cognitive decline, in the absence of evidence of neurodegenerative disease. Data is shown in mean (SD). Results: 516 patients (61% females, mean age 70.76±10.3 years) with a mean of 4.5 (+-3.94) years of education were referred. The diagnoses were: FCD (146, 28.3%); Alzheimer’s dementia (115, 22.3%); Mild Cognitive Impairment (51, 9.9%), vascular dementia (36, 7%); other types, including less common causes of dementia and rare pathologies (168, 7.6%). FCD patients were younger (66.2 (±9.4) vs. 72.6, p <0.001), and showed higher Geriatric Depression Scale than non-FCD patients (7.4 (±4.5) vs. 5.3 (±3.7), p <0.001). Education level did not differ. Conclusions: FCD was the most frequent diagnosis. Primary care strategies may greatly improve early diagnosis and treatment to these patients.
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Formoso, Carolina Rodrigue, Raphael Machado Castilhos, Wyllians Vendramini Borelli, Matheus Zschornack Strelow, and Marcia Fagundes Chaves. "ANTICHOLINERGIC BURDEN IN DEMENTIA." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda031.
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Background: The anticholinergic burden is associated with a greater risk of functional/ cognitive decline and morbidity/mortality. Objectives: Our aim was to quantify the anticholinergic burden in the first visit in our dementia tertiary outpatient clinic. Methods: We performed a retrospective analysis of all first visit medical records of patients referred from primary health care to the outpatient dementia clinic of a tertiary hospital in Porto Alegre with a final diagnosis of dementia or Mild Cognitive Impairment (MCI) between 2014-2019. We evaluated all medications in use and we calculated a final score using Brazilian Anticholinergic Activity Drug (BAAD) score. This scale classified drugs according to its central anticholinergic activity from 1 to 3, with higher values indicating greater activity. The final score is the sum of the score for each drug. We divided the sample in two groups (score=0 and ⩾ 1) and performed a logist regression using age, sex, dementia diagnosis and MMSE as covariates. Results: We identified 199 final diagnoses of dementia (mostly Alzheimer’s Disease (AD) [45.2%]) and 39 of MCI. Most patients with dementia (76.4%) and MCI (74.3%) had at least a BAAD score = 1. Median (IQI) BAAD score was higher in VD, 4 (1.0-6.5). In the regression analysis, BAAD score was associated with MMSE, controlling for covariates. Conclusions: In our sample, the anticholinergic burden was high and correlated with dementia severity.
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Cecato, Juliana, and Livia Galeote. "SENILITY AND COGNITIVE PERFORMANCE: ANALYSIS OF WECHSLER SCALE IN ELDERLY WITH MAJOR NEUROCOGNITIVE DISORDER." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda074.
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Background: CHC theory is a hierarchical model of intelligence, organized through cognitive skills and dividing the construct into crystallized and fluid. Objective: To describe the correlation among crystallized and fluid abilities in healthy people diagnosed with dementia. Methods: 45 subjects with 50 to 89 years old and at least 1 year of schooling. They were submitted to a detailed clinical interview and, later, to a neuropsychological evaluation. RAVLT, Wechsler Intelligence Scale (WAIS-III or WASI) and FDT were applied. Sample was divided into 2 groups: healthy elderly (without cognitive and functional decline) and those diagnosed with dementia (GE). The diagnosis of dementia was based on the DSM-5. Results: RAVLT and the Wechsler Scale differentiated HE from DG (p <0.0001). FDT did not show a statistically significant difference in the Counting, Reading and Inhibition items, showing that tasks involve time were not able to differentiate healthy individuals from DG. To compare the performance IQ it is evident that the performance in fluid skills is less effective, when compared to the crystallized items (IQ verbal), in differentiating healthy subjects from dementia. Conclusion: Tasks involving learning, delayed recall memory and recognition, that is, crystallized tasks, are more effective in differentiating dementia when compared to fluid tasks (processing speed).
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Yanickiy, Mihail, A. V. Soloduhin, and Andrey Seryy. "COGNITIVE IMPAIRMENT IN SOMATIC DISEASES: ETIOPATHOGENESIS, DIAGNOSTIC METHODS AND POSSIBILITIES OF PSYCHOLOGICAL CORRECTION." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-157.
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The general clinical and psychological characteristics of cognitive disorders in somatic diseases
are given. Groups of such disorders are distinguished depending on their etiology. Methods of diagnosis
of cognitive disorders are characterized and psychological methods of their correction are substantiated.
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Santos, Priscila, Daniel Godoy Pinto, Jussara Alves Celestino, and Marina Cisoto. "MentalPlus® as a Tool for Early Detection of Dementias." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.355.
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Introduction: The research’s objective is to identify early signs and symptoms of dementia through the MentalPlus® game. Dementias is a Neurocognitive Major Disorder, and as a diagnostic criterion, it is impaired in the areas of intricate attention, executive function, learning, memory, language, perceptomotor or social cognition. Method: MentalPlus® was created for timely evaluation and cognitive rehabilitation, considering the various diseases that cause cognitive dysfunction, such as dementia, heart problems, organic disorders, among others, in addition to surgical interventions and external factors. This instrument used to evaluate postoperative cognitive dysfunctions, which often affect elderly patients, confirms the validity and accessibility of the MentalPlus application. Results: Table 1 shows that the elderly in the group tested had statistically lower education than the control group (p < 0.001). Table 2 shows that for all domains of MentalPlus , on the hits part, the tested elderly group showed statistically lower values than the control group (p < 0.05), except only in the executive function (p = 0.231) and selective attention (p = 0.057), errors were also statistically higher in the elderly tested for almost all domains (p < 0.05), except in short-term memory (p = 0.206) and long-term memory (p = 0.179). At the same time, omissions were statistically higher in the elderly tested for all MP domains (p < 0.05). Conclusion: MentalPlus® identifies early signs of dementia in older people and is useful for the evaluator and the target audience, as it provides reliable data in a considerably short time.
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Socher, Karen, Douglas Nunes, Deborah Lopes, Artur Coutinho, Daniele Faria, Paula Squarzoni, Geraldo Busatto Filho, Carlos Buchpighel, Ricardo Nitrini,, and Sonia Brucki. "VISUAL MEDIAL TEMPORAL ATROPHY SCALES IN CLINICIAN PRACTICE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda102.
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Background: Visual atrophy scales from the medial temporal region are auxiliary biomarker methods in Alzheimer’s Disease(AD).They may correlated with progression from preclinical to clinical AD. Objective: We aimed to compare medial temporal lobe atrophy (MTA) and entorhinal cortex atrophy (ERICA) scales for magnetic resonance image as a useful tool for probable AD diagnosis and evaluate their accuracy, sensitivity and specificity, regarding clinical diagnosis and 11C-PIB-PET. Methods: 2 neurologists blinded to diagnosis classified 113 adults (over 65y) through MTA and ERICA scales and correlated with sociodemographic data, amyloid brain cortical burden through the 11C-PIB-PET and clinical cognitive status, divided into 30 cognitive unimpaired (CU) individuals, 52 MCI and 31 dementia compatible with AD (DCAD). Results: Inter-rater reliability of these atrophy scales was excellent (0.8- 1) by Cohen analysis. CU group had significantly lower MTA scores (median value 0) than ERICA (median value 1)for both hemispheres. 11C-PIB-PET was positive in 45% of the whole sample. In MCI and DCAD groups, ERICA depicted greater sensitivity and MTA greater specificity. Accuracy was under 70% for both scores in all clinical groups. Conclusion: Our study achieved a moderate sensitivity for ERICA score and could be a better screening tool for DCAD or MCI than MTA score. But, none of them could be considered a useful biomarker in preclinical AD.
Reports on the topic "Cognition disorders – Diagnosis"
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Madu, Laura, Jacqueline Sharp, and Bobby Bellflower. Efficacy of Integrating CBT for Mental Health Care into Substance Abuse Treatment in Patients with Comorbid Disorders of Substance Abuse and Mental Illness. University of Tennessee Health Science Center, April 2021. http://dx.doi.org/10.21007/con.dnp.2021.0004.
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Abstract: Multiple studies have found that psychiatric disorders, like mood disorders and substance use disorders, are highly comorbid among adults with either disorder. Integrated treatment refers to the treatment of two or more conditions and the use of multiple therapies such as the combination of psychotherapy and pharmacotherapy. Integrated therapy for comorbidity per numerous studies has consistently been superior to the treatment of individual disorders separately. The purpose of this QI project was to identify the effectiveness of Cognitive Behavioral Therapy (CBT) instead of current treatment as usual for treating Substance Use Disorder (SUD) or mental health diagnosis independently. It is a retrospective chart review. The review examines CBT's efficacy for engaging individuals with co-occurring mood and substance u se disorders in treatment by enhancing adherence and preventing disengagement and relapse. Methods: Forty adults aged 26-55 with a DSM-IV diagnosis of a mood disorder of Major Depressive Disorder and/or anxiety and concurrent substance use disorder (at least weekly use in the past month). Participants received 12 sessions of individual integrated CBT treatment delivered with case management over a 12-week period. Results: The intervention was associated with significant improvements in mood disorder, substance use, and coping skills at 4, 8, and 12 weeks post-treatment. Conclusions: These results provide some evidence for the effectiveness of the integrated CBT intervention in individuals with co-occurring disorders. Of note, all psychotherapies are efficacious; however, it would be more advantageous to develop a standardized CBT that identifies variables that facilitate treatment outcomes specifically to comorbid disorders of substance use and mood disorders. It is concluded that there is potentially more to be gained from further studies using randomized controlled designs to determine its efficacy.
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Robledo-Castro, Carolina, Gisella Bonilla-Santos, and Piedad Rocío Lerma-Castaño. Computer-based cognitive training programs: effects on executive functions in children with attention deficit hyperactivity disorder (ADHD). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0046.
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Review question / Objective: This systematic review aimed to synthesize the existing literature reporting the effects of computer-based cognitive training on the executive functions of children with ADHD. Condition being studied: Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder diagnosed in childhood, characterized by a persistent pattern of inattention, hyperactivity, and impulsivity. Today it is recognized that ADHD is associated with an alteration in the volume and level of activation in prefrontal areas related to executive functions. Based on these clinical findings, some authors suggest that ADHD is not a disorder of primary attention origin but instead responds to an alteration in the synaptic circuits of some brain areas, including the prefrontal neocortex, areas involved in cognitive regulation and control, and processes known as executive functions.
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Osadchyi, Viacheslav V., Hanna B. Varina, Kateryna P. Osadcha, Olesia O. Prokofieva, Olha V. Kovalova, and Arnold E. Kiv. Features of implementation of modern AR technologies in the process of psychological and pedagogical support of children with autism spectrum disorders. [б. в.], November 2020. http://dx.doi.org/10.31812/123456789/4413.
Full textAbstract:
The article deals with the actual issue of the specificity and algorithm of the introduction of innovative AR technologies in the process of psychological and pedagogical support of children with autism spectrum disorders (ASD). An innovative element of theoretical and methodological analysis of the problem and empirical research is the detection of vectors of a constructive combination of traditional psycho-correctional and psycho-diagnostic approaches with modern AR technologies. The analysis of publications on the role and possibilities of using AR technologies in the process of support children with ASD (autism spectrum disorder) and inclusive environment was generally conducted by surfing on the Internet platforms containing the theoretical bases for data publications of scientific journals and patents. The article also analyzes the priorities and potential outcomes of using AR technologies in psycho-correction and educational work with autistic children. According to the results of the analysis of scientific researches, Unified clinical protocol of primary, secondary (specialized), tertiary (highly specialized) medical care and medical rehabilitation “Autism spectrum disorders (disorders of general development)”, approaches for correction, development and education of children with ASD, AR technologies were selected for further implementation in a comprehensive program of psychological and pedagogical support for children with ASD. The purpose of the empirical study is the search, analysis and implementation of multifunctional AR technologies in the psycho-correctional construct of psychological and pedagogical support of children with ASD. According to the results of the pilot study, the priorities and effectiveness of using AR technologies in the development of communicative, cognitive, emotional-volitional, mnemonic abilities of children and actualization of adaptive potential and adaptive, socially accepted behaviors are made. The possibilities and perspectives of using AR technologies as an element of inclusive environment, with regard to nosology and phenomenology, need further investigation.
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The Centre for Attention Learning and Memory (CALM) Approach to Neurodevelopmental Research – MRC Cognition and Brain Sciences Unit University Of Cambridge. ACAMH, April 2021. http://dx.doi.org/10.13056/acamh.15509.
Full textAbstract:
Our thinking around neurodevelopmental disorders is undergoing a period of rapid change. The traditional approach, endorsed by classification systems such as the Diagnostic Statistical Manual, defines neurodevelopmental disorders such as autism and attention-deficit hyperactivity disorder (ADHD) as distinct categories.
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Language stability in primary school-aged children hinders catch up for those with language disorders. ACAMH, May 2018. http://dx.doi.org/10.13056/acamh.10552.
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In 2017, the Journal of Clinical Psychology and Psychiatry published the latest results of the Surrey Communication and Language in Education Study (SCALES), in which Courtenay Frazier Norbury and colleagues investigated language growth and stability in a population cohort of children with varying degrees of verbal and nonverbal cognitive abilities and a wide range of additional diagnoses.
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Roles of Speech-Language Pathologists in the Identification, Diagnosis, and Treatment of Individuals With Cognitive-Communication Disorders: Position Statement. Rockville, MD: American Speech-Language-Hearing Association, 2005. http://dx.doi.org/10.1044/policy.ps2005-00110.
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PTSD in very young children, and proof-of-concept trial – In Conversation Prof. Tim Dalgleish. ACAMH, September 2021. http://dx.doi.org/10.13056/acamh.17201.
Full textAbstract:
The focus of this podcast is on the JCPP paper 'The early course and treatment of posttraumatic stress disorder in very young children: diagnostic prevalence and predictors in hospital-attending children and a randomized controlled proof-of-concept trial of trauma-focused cognitive therapy, for 3- to 8-year-olds'