Relevant bibliographies by topics / Cognition disorders

Academic literature on the topic 'Cognition disorders'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Cognition disorders"

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Fourrier, Célia, Gaurav Singhal, and Bernhard T. Baune. "Neuroinflammation and cognition across psychiatric conditions." CNS Spectrums 24, no. 1 (February 2019): 4–15. http://dx.doi.org/10.1017/s1092852918001499.

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Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder, bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the quality of life of patients and the recovery of those conditions. There is therefore a great need for consideration for cognitive dysfunction in the management of psychiatric disorders. The redundant pattern of cognitive impairments across such conditions suggests possible shared mechanisms potentially leading to their development. Here, we review for the first time the possible role of inflammation in cognitive dysfunctions across psychiatric disorders. Raised inflammatory processes (microglia activation and elevated cytokine levels) across diagnoses could therefore disrupt neurobiological mechanisms regulating cognition, including Hebbian and homeostatic plasticity, neurogenesis, neurotrophic factor, the HPA axis, and the kynurenine pathway. This redundant association between elevated inflammation and cognitive alterations across psychiatric disorders hence suggests that a cross-disorder approach using pharmacological and nonpharmacological (ie, physical activity and nutrition) anti-inflammatory/immunomodulatory strategies should be considered in the management of cognition in psychiatry.
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Doyle, Alysa E., Pieter J. Vuijk, Nathan D. Doty, Lauren M. McGrath, Brian L. Willoughby, Ellen H. O’Donnell, H. Kent Wilson, et al. "Cross-Disorder Cognitive Impairments in Youth Referred for Neuropsychiatric Evaluation." Journal of the International Neuropsychological Society 24, no. 1 (August 4, 2017): 91–103. http://dx.doi.org/10.1017/s1355617717000601.

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AbstractObjectives: Studies suggest that impairments in some of the same domains of cognition occur in different neuropsychiatric conditions, including those known to share genetic liability. Yet, direct, multi-disorder cognitive comparisons are limited, and it remains unclear whether overlapping deficits are due to comorbidity. We aimed to extend the literature by examining cognition across different neuropsychiatric conditions and addressing comorbidity. Methods: Subjects were 486 youth consecutively referred for neuropsychiatric evaluation and enrolled in the Longitudinal Study of Genetic Influences on Cognition. First, we assessed general ability, reaction time variability (RTV), and aspects of executive functions (EFs) in youth with non-comorbid forms of attention-deficit/hyperactivity disorder (ADHD), mood disorders and autism spectrum disorder (ASD), as well as in youth with psychosis. Second, we determined the impact of comorbid ADHD on cognition in youth with ASD and mood disorders. Results: For EFs (working memory, inhibition, and shifting/ flexibility), we observed weaknesses in all diagnostic groups when participants’ own ability was the referent. Decrements were subtle in relation to published normative data. For RTV, weaknesses emerged in youth with ADHD and mood disorders, but trend-level results could not rule out decrements in other conditions. Comorbidity with ADHD did not impact the pattern of weaknesses for youth with ASD or mood disorders but increased the magnitude of the decrement in those with mood disorders. Conclusions: Youth with ADHD, mood disorders, ASD, and psychosis show EF weaknesses that are not due to comorbidity. Whether such cognitive difficulties reflect genetic liability shared among these conditions requires further study. (JINS, 2018, 24, 91–103)
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Woodruff, Bryan. "Disorders of Cognition." Seminars in Neurology 31, no. 01 (February 2011): 018–28. http://dx.doi.org/10.1055/s-0031-1271314.

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de Sousa, Paulo, William Sellwood, Martin Griffiths, and Richard P. Bentall. "Disorganisation, thought disorder and socio-cognitive functioning in schizophrenia spectrum disorders." British Journal of Psychiatry 214, no. 2 (August 24, 2018): 103–12. http://dx.doi.org/10.1192/bjp.2018.160.

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BackgroundPoor social cognition is prevalent in schizophrenia spectrum disorders. Some authors argue that these effects are symptom-specific and that socio-cognitive difficulties (e.g. theory of mind) are strongly associated with thought disorder and symptoms of disorganisation.AimsThe current review tests the strength of this association.MethodWe meta-analysed studies published between 1980 and 2016 that tested the association between social cognition and these symptoms in schizophrenia spectrum disorders.ResultsOur search (PsycINFO, MEDLINE and Web of Science) identified 123 studies (N = 9107). Overall effect size as r = −0.313, indicating a moderate association between symptoms and social cognition. Subanalyses yielded a moderate association between symptoms and theory of mind (r = −0.349) and emotion recognition (r = −0.334), but smaller effect sizes for social perception (r = −0.188), emotion regulation (r = −0.169) and attributional biases (r = −0.143).ConclusionsThe association is interpreted within models of communication that highlight the importance of mentalisation and processing of partner-specific cues in conversational alignment and grounding.Declaration of interestsNone.
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Chamard, Ludivine, Sabrina Ferreira, Alexa Pijoff, Manon Silvestre, Eric Berger, and Eloi Magnin. "Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia." Behavioural Neurology 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6423461.

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Objectives. To describe cognitive assessment including social cognition in SPG4 patients.Methods. We reported a series of nine patients with SPG4 mutation with an extensive neuropsychological examination including social cognition assessment.Results. None of our patients presented with mental retardation or dementia. All presented with mild cognitive impairment with a high frequency of attention deficit (100%), executive disorders (89%), and social cognition impairment (78%). An asymptomatic patient for motor skills presented with the same cognitive profile. No correlation was found in this small sample between cognitive impairment and motor impairment, age at disease onset, or disease duration.Conclusions. SPG4 phenotypes share some cognitive features of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Cognitive disorders including executive disorders and social cognition impairment are frequent in SPG4 patients and might sometimes occur before motor disorders. Therefore, cognitive functions including social cognition should be systematically assessed in order to improve the clinical management of this population.
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Kauliņa, Anda. "Cognitive Analysis of 9 to 11-Year-Old Children With Intellectual Development Disorders." Journal of Pedagogy and Psychology "Signum Temporis" 9, no. 1 (December 20, 2017): 16–22. http://dx.doi.org/10.1515/sigtem-2017-0006.

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Abstract Cognitive development significantly influences efficiency and results of child’s understanding and comprehension of the world. Attention and cognition play a significant role to ensure academic achievement and success. Attention is essential for purposeful planning of action and systematic work. Attention is necessary to follow the study material and for physical survival in everyday life. Cognition is significant in decision making and evaluating possible outcomes, being especially important in children with cognitive development disorders. The aim of the present study was to find out the peculiarities of the cognitive processes in 9 to 11-year-old children with cognitive development disorders. Previous literature suggests that children with intellectual development disorders are at increased risk of general cognitive disorders. To test this assumption and establish cognitive abilities in children with intellectual development disorders, the following subtests of the Vienna Test System (VTS) were used: CPM/S2 (Raven's Coloured Progressive Matrices), B19 (Double Labyrinth Test) and WAFF (Perception and Attention Functions: Focused Attention). VTS is one of the leading computer-based psychophysiological testing systems in Europe. In addition to testing, behavioural observations were also carried out. Study results reveal that children with a shared diagnosis are not as similar when it comes to cognition and attention. Not all children within the sample group exhibited reduced attention and concentration, although the whole participant sample was diagnosed with intellectual development disorder. Meanwhile, risk factors hindering normal cognitive development were identified.
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Jones, Barbara Pendleton, Connie C. Duncan, Pim Brouwers, and Allan F. Mirsky. "Cognition in eating disorders." Journal of Clinical and Experimental Neuropsychology 13, no. 5 (September 1991): 711–28. http://dx.doi.org/10.1080/01688639108401085.

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Gjelsvik, Bergljot, Darko Lovric, and J. Mark G. Williams. "Embodied cognition and emotional disorders." Journal of Experimental Psychopathology 9, no. 3 (July 1, 2018): pr.035714. http://dx.doi.org/10.5127/pr.035714.

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Research into embodied cognition (EC) in cognitive neuroscience and psychology has risen exponentially over the last 25 years, covering a vast area of research; from understanding how ability to judge speech sounds depends on an intact motor cortex, to why people perceive hills as steeper when carrying a heavy backpack. Although there are many theories addressing these phenomena, increasing evidence across EC studies suggests simulation (i.e., re-enactment of the motor-sensory aspects of meaning) as an important basis of knowledge. The authors 1) review evidence for the EC paradigm’s claim to simulation effects in cognition, suggesting that simulation exists within a “distributed plus hub” model, 2) discuss the implications of simulation for the understanding of cognitive dysfunctions in emotional disorders, particularly depression, 3) suggest that emotional disorders arises as a result of failed simulation processes, hypothesizing that semantic processing reactivates motor-sensory simulations previously associated with low mood ( enactment/re-enactment networks), and that truncation of such simulation by means of over-use of language-based, abstract processing, motivated by a wish to reduce the affective disturbance associated with episodic, embodied representations, maintains psychopathology, 4) review evidence for effects of truncated simulation on emotional pathology, and 5) discuss the relevance of EC to treatments of emotional pathology.
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Eifert, Georg H., and Lyn Craill. "The Relationship between Affect, Behaviour, and Cognition in Behavioural and Cognitive Treatments of Depression and Phobic Anxiety." Behaviour Change 6, no. 2 (June 1989): 96–103. http://dx.doi.org/10.1017/s0813483900007634.

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Cognitive theories and therapies of emotional dysfunctions are based on the premise that the affective, behavioural, and cognitive response repertoires are fused and highly interdependent. Such views have been criticised with the argument that affect and cognition are relatively independent and that there is a much more direct and stronger link between affect and behaviour. In an attempt to clarify potential differences in the interplay between affect, behaviour, and cognition in unipolar depression and phobic anxiety, a quantitative review of the relative efficacy of performance-based (behavioural) versus cognitive intervention for these disorders was conducted. The relative superiority of cognitive over performance-based interventions in the treatment of unipolar depression supports the notion of a reasonably direct link between cognition and affect for this disorder providing a fairly effective pathway for treatment. On the other hand, the relative success of performance-based techniques in the treatment of phobias suggests that for these disorders the link between behaviour and affect is more direct and much stronger than the link between cognition and affect. It is concluded that the relative effectiveness of cognitive and performance-based intervention techniques depends on and points to differences in the specific type of affect-behaviour-cognition interface that underlies and is controlling depression and phobic anxiety.
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Alghamdi, Huda Othman. "Relationship Between Behavioural Disorders and Social Cognition among Orphans in Saudi Arabia." International Education Studies 13, no. 6 (May 27, 2020): 85. http://dx.doi.org/10.5539/ies.v13n6p85.

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This study aimed to investigate the relationship between behavioural disorders and social cognition among orphans in Saudi Arabia by adopting a phenomenological qualitative approach. To achieve this aim, 50 subjects were selected to participate in this study through a purposive sampling. The participants were subjected to a semi-structured interview session which lasted from 45 minutes to an hour. After data has been gathered, Interpretative Phenomenological Analysis was used to analyse data into themes which were categorized into three: Symptoms of Behavioural Disorders, Social Cognitions, and Factors. The results of the study showed that emotional and behavioural disorders that orphans face in Saudi Arabia were manifested by symptoms of disorders such as Posttraumatic Stress Disorder, Oppositional Defiant Disorder, and Social Phobia. Factors that tend to have a significant effect on behavioural problems among orphans consisted of traumatic events, events prior to admittance in the orphanage such as physical abuse, and the overall physical environment of the orphanage, which can be at risk of being conducive for bullying and fighting among orphans. Furthermore, there might be a relationship between behavioural disorders and social cognition among orphans in Saudi Arabia.
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Dissertations / Theses on the topic "Cognition disorders"

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Airaksinen, Eija. "Cognitive functions in depression and anxiety disorders : findings from a population-based study /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-954-8/.

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Lynham, Amy. "Measuring cognition across mood and psychotic disorders." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/116386/.

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Cognitive impairments are present in both schizophrenia and bipolar disorder and are strong predictors of functional outcomes for patients. One barrier in cognitive research of these disorders is the lack of large, well-characterised cross-disorder samples with cognitive data. The aims of this thesis were to examine cognition across the bipolar / schizophrenia diagnostic spectrum and to develop a new online cognitive battery for use in psychiatric research. Cognition was examined in participants with bipolar disorder, schizoaffective disorder and schizophrenia through a meta-analysis of existing studies and analysing data from a large well-characterised sample. The main finding was that there is a gradient of increasing cognitive impairment from bipolar disorder through schizoaffective disorder – bipolar type to schizoaffective disorder – depressive type and schizophrenia. Participants with the subtypes of schizoaffective disorder differed in their cognitive performance. Lifetime history of psychosis was associated with cognitive performance across disorders. An online cognitive battery was developed to assess the domains outlined by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. The battery was validated against the MATRICS Consensus Cognitive Battery and showed that the tasks provided valid measurements of the majority of the MATRICS domains. A large sample of participants with a range of psychiatric disorders was recruited online. An examination of cognition in participants with major depressive disorder, bipolar disorder and schizophrenia showed that cognitive profiles were similar across disorders but participants with schizophrenia have more severe impairments than participants with bipolar disorder. An important concluding observation was that poorer cognitive performance was associated with poorer functional outcome across disorders. The findings of this thesis add to a growing literature showing the importance of examining cognitive function across psychiatric disorders. To date, it is the first study to develop and utilise an online cognitive assessment for psychiatric research.
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Nowotny, Ewa. "Social cognition and HIV-associated neurocognitive disorders." Thesis, University of East London, 2016. http://roar.uel.ac.uk/5399/.

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Introduction: The introduction of antiretroviral therapy has successfully transformed the Human Immunodeficiency Virus (HIV) into a long-term condition. However, nearly half of those living with HIV experience cognitive difficulties (HIV-associated Neurocognitive Disorders; HAND). The adverse effects of HIV on cognitive function have been well-documented. However, it has not been established whether individuals with HAND present with deficits in social cognition, specifically related to the ability to understand other people’s intentions and feelings (Theory of Mind; ToM). The present study aimed to address this gap in the research and explore whether individuals with HAND show deficits in cognitive and affective aspects of ToM, and whether these are related to general cognitive abilities. Method: Sixteen individuals with HAND between the ages of 26 and 60 (mean age = 46.81 years) were recruited from a rehabilitation centre for individuals living with HAND. Participants completed a neuropsychological test battery and two social cognition tests (verbal test of cognitive ToM and visual test of affective ToM). Data obtained using standardised measures was analysed quantitatively and descriptively. Results: The individual and group-level analyses indicate that individuals with HAND show impairments in social cognition, with greater deficits observed in the domain of mentalising (cognitive ToM) than affect recognition (affective ToM). Consistent with the correlational analyses, tentative links can be made between social cognition and processing speed, executive function and memory, although the manner in which these domains impact on social cognition requires further research. Implications: A key clinical implication is that social cognition should be routinely tested in individuals with HAND as part of a standard assessment of cognitive function. The findings further indicate that it might be useful to evaluate multiple domains of social cognition and interpret the results in the context of findings from other neuropsychological assessments.
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Crino, Natalie. "Metacognition and eating disorders." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12643.

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Cognitive theories of emotional disorder maintain that psychological dysfunction is associated with a disturbance in thoughts and beliefs. In contrast, the self-regulatory executive function theory of emotional disorder (Wells & Matthews, 1994), posits that psychological disturbance is associated with metacognitive beliefs that promote the use of dysfunctional metacognitive control strategies. The aim of the thesis was to investigate whether metacognitive beliefs and metacognitive control strategies are associated with symptoms and features of eating disorders. In pursuit of this aim, two studies were undertaken examining: features of cognition between diagnostic groups, and compared to a non-clinical group; the inter-relatedness of cognitive and metacognitive constructs and their associations with symptoms; strategy-use during body exposure and cognitive predictors of state- and physical appearance anxiety; cognitive and metacognitive predictors of early treatment response in patients undergoing cognitive behaviour therapy (CBT) for an eating disorder. In Study 1, 90 clinical- and 108 non-clinical participants engaged in a guided 3-minute body exposure task, and then completed questionnaires measuring affective state, and engagement in- and efficacy of thought control strategies. In Study 2, 103 clinical participants engaged in either day-hospital or outpatient CBT. After 12-weeks of treatment, symptom measures were re-administered. The overall results indicated that, firstly, eating disorder subgroups have a similar cognitive profile, but differ substantially from a non-clinical group. Secondly, the pattern of inter-relationships between cognitive and metacognitive variables was found to be multidimensional. Thirdly, the clinical group displayed a greater tendency to use maladaptive thinking strategies in general, but not under body exposure conditions. Fourthly, metacognitive variables were only found to be associated with features of the disorder that are not specific to eating disorders. However, they were found to predict degree of treatment change in dietary restraint, bulimia, body dissatisfaction and stress, which suggests that targeting metacognitive processes may be important for facilitating change in these symptoms.
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Eddy, Clare Margaret. "Social cognition in disorders of the basal ganglia." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/366/.

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Patients with disorders of the basal ganglia, such as Parkinson’s disease, Huntington’s disease and Tourette’s Syndrome, exhibit characteristic motor symptoms and less obvious cognitive deficits. These deficits can be understood with reference to the model of cortico-striato-thalamo-cortical circuitry proposed by Alexander et al. (1986) which highlights how the basal ganglia can affect the functioning of the whole of the frontal lobe. This thesis explored the possibility that patients with these disorders also have difficulties with social cognition. Patients with Parkinson’s exhibited deficits in reasoning about mental states. These deficits can largely be attributed to executive dysfunction which results from disordered activity in the circuitry linking the dorsolateral prefrontal cortex and the basal ganglia. Patients with Huntington’s exhibited reduced fear responses which most likely results from abnormal amygdala activity. Patients with Tourette’s exhibited deficits on a wide range of social cognitive tasks involving reasoning about mental states, non-literal language interpretation and economic decision making. These difficulties probably reflect dysfunction in circuitry linking the anterior cingulate and insula with the basal ganglia. These studies offer insight into the neuroanatomical basis of the behavioural symptoms associated with these conditions whilst highlighting the necessity to develop more precise and inclusive models of frontostriatal circuitry.
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Fish, Scott Christopher. "Pupillary response measures of processing resource allocation during theory of mind task performance in schizophrenia." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3360156.

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Thesis (Ph. D.)--University of California, San Diego and San Diego State University, 2009.
Title from first page of PDF file (viewed August 11, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 36-39).
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Whitcomb-Smith, Stacy. "The Role of Cognitive Factors in the Development of Seasonal Affective Disorder Episodes." Fogler Library, University of Maine, 2003. http://www.library.umaine.edu/theses/pdf/Whitcomb-SmithS2003.pdf.

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Lee, W. "Subjective cognitive impairments in Schizophrenia and related disorders." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31384948.

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王得寶 and Tak-po Mike Wong. "Memory profile of people with mild cognitive impairment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41547834.

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Wong, Tak-po Mike. "Memory profile of people with mild cognitive impairment." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41547834.

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Books on the topic "Cognition disorders"

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Damasceno, Benito. Research on Cognition Disorders. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-57267-9.

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Lahera, Guillermo, Paloma García-Ramo, and Salvador Ruiz-Murugarren. Social cognition in bipolar disorder. New York: Nova Science Publishers, 2012.

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McDonald, Skye. Clinical Disorders of Social Cognition. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003027034.

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J, Stein Dan, and Young Jeffrey E. 1950-, eds. Cognitive science and clinical disorders. San Diego: Academic Press, 1992.

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Kimbarow, Michael L. Cognitive communication disorders. San Diego: Plural Publishing Inc., 2011.

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Ira, Margolin David, ed. Cognitive neuropsychology in clinical practice. New York: Oxford University Press, 1992.

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A, Magaro Peter, ed. Cognitive bases of mental disorders. Newbury Park, Calif: Sage, 1991.

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Snowling, Margaret J. Dyslexia: A cognitive developmental perspective. Oxford, UK: B. Blackwell, 1990.

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Fairburn, Christopher G. Cognitive behavior therapy and eating disorders. New York: Guilford Press, 2008.

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Roland, Jouvent, Chapouthier Georges, France. Ministère de l'enseignement supérieur et de la recherche., and Maison des sciences de l'homme (Paris, France). Fondation., eds. La cognition réparée ?: Perturbations et récupérations des fonctions cognitives. Paris, France: Fondation maison des sciences de l'homme, 2008.

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Book chapters on the topic "Cognition disorders"

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Freudenreich, Oliver. "Cognition in Schizophrenia." In Psychotic Disorders, 385–97. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-29450-2_29.

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Gregg, Noël. "Spelling Disorders." In Neuropsychology and Cognition, 14–33. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0297-1_2.

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Gregg, Noël. "Motor Disorders." In Neuropsychology and Cognition, 91–105. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0297-1_5.

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Foidel, Sarah E. "Evaluating Cognition and Performance Through Cognitive Domains." In Neurocognitive Behavioral Disorders, 71–98. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11268-4_4.

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Gregg, Noël. "Written Syntax Disorders." In Neuropsychology and Cognition, 34–53. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0297-1_3.

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Schaller, Ulrich Max, and Reinhold Rauh. "Moral Cognition." In Encyclopedia of Autism Spectrum Disorders, 1–9. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4614-6435-8_102404-1.

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Bauminger-Zviely, Nirit. "Social Cognition." In Encyclopedia of Autism Spectrum Disorders, 2883–84. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_107.

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Bauminger-Zviely, Nirit. "Social Cognition." In Encyclopedia of Autism Spectrum Disorders, 4416–17. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_107.

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Schaller, Ulrich Max, and Reinhold Rauh. "Moral Cognition." In Encyclopedia of Autism Spectrum Disorders, 2966–74. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_102404.

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Hedges, Dawson, Thomas J. Farrer, Erin D. Bigler, and Ramona O. Hopkins. "Cognition in Affective Disorders." In The Brain at Risk, 21–35. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14260-5_2.

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Conference papers on the topic "Cognition disorders"

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Santana, Beatriz Franco de, Flávia Arbex Borim, Deusivania Silva Falcão, Meire Cachioni, Samila Tavares Batistoni, Ruth Melo, Anita Neri, and Monica Yassuda. "COGNITION, FUNCTIONAL STATUS AND FRAILTY AMONG THE OLDEST OLD." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda101.

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Background: Frailty is defined as a recognizable state of increased vulnerability resulting from age-associated decline of function in various physiological systems. Objective: To assess possible associations between cognition, function status and frailty in a sample of oldest old with performance below cut off scores for dementia in the MMSE. Methods: Sociodemographic, cognitive, functional status and frailty data were obtained from 130 individuals.Frailty was defined by Fried’s frailty phenotype.Functional status was measured by the Functional Activities Questionnaire.The Cognitive Dementia Rating scale was applied to assess dementia severity. Results: In all,28% were male and 72% female,mean age of 82.4 years(SD=5.3).40% were illiterate and 94% had held jobs based on manual activity.In the sample 54.6% had functional impairment.Among participants with normal cognition and functional status,6.1% were frail,8.4% pre-frail and 7.6% robust,among those with impaired cognition and preserved functional status,13% were frail,6.9% pre-frail and 0.7% robust;among those with impaired cognition and functional status,30,7% were frail,19.2% pre-frail and 4.6% robust;and among those with preserved cognition and impaired functional status,0% were frail or robust and 2.3% pre-frail. Conclusion: Participants with impaired cognition and functional status included the largest number of frail and pre-frail participants. These results suggest that impaired cognition and functional status are associated with frailty among the oldest old.
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Dourado, Marcia, José Pedro Simões Neto, Gilberto Alves, and Cândida Alves. "FACIAL EXPRESSION RECOGNITION IN MILD AND MODERATE ALZHEIMER’S DISEASE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda006.

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Background: Facial expression recognition is essential for social cognition. Objectives: To compare facial expression recognition in mild and moderate Alzheimer’s disease (AD) and identify the cognitive and clinical factors associated with impairment according to disease severity. Methods: Participants with AD (n=52). FACES includes four subtasks: matching expressions with picture stimuli (tasks1and 2), labelling emotions (task 3) and recognizing emotional situations (task 4). Results: There were significant differences between groups in FACES global score, task 2 and task 4. In mild AD, FACES global score was related to educational level and cognition; comprehension and constructive praxis impacted task 1; cognitive flexibility impacted task 2, and task 3 was related to word finding. There were no significant associations in task 4 after adjusting for level of cognition. The moderate AD group showed that awareness of emotional state was related to FACES global score, constructive praxis impacted task 2, task 3 was related to neuropsychiatric symptoms, and the ability to recognize emotions through situations impacted task 4. There was no significant associations in task 2, after adjusting for level of cognition. Conclusions: There are emotional processing difficulties across AD stages. However, there was no influence of cognitive impairment in the recognition of emotional situations in both groups.
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Silva, Rogeria Cristina, Raquel Luíza Carvalho, and Marcia Cristina Dourado. "THE IMPACT OF ALZHEIMER’S DISEASE ON EMOTIONAL PROCESSING." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda053.

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Background: Emotional processing involves the ability of the individual to infer emotional information. There is no consensus about how Alzheimer’s disease (AD) affects emotional processing. Objective: We aim to systematically review the impact of AD on emotion processing Method: We conducted a search based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The literature search was performed using the electronic databases MEDLINE (Pubmed) and Science Citation Index (ISI). The following descriptors were used in the review process: emotion or emotional processing, cognition or cognitive functions and Alzheimer disease or Alzheimer’s disease. This systematic review was recorded in the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42018115891. Results: We identified 425 articles, 19 of which met our criteria. Visual emotional stimuli were the most used among studies. Most studies used tasks of emotional naming, discrimination, identification and correspondence. The results were contradictory. Many studies reported that individuals with AD were impaired on emotional perception tasks, while others results reported preserved skills. The relationship between emotional processing and cognition is also unclear. Some studies suggested that general cognitive performance affects performance in emotional perception tasks among people with AD, but other studies have shown deficits in recognizing emotion, regardless cognitive performance. Conclusions: Studies are scarce, present contradictory results, and report impairment in emotional processing in relation to cognition. Moreover, analyzes of correlation between emotion processing and cognitive functioning failed to reveal clear relationships.
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Fernandes, Katarina, Henrique da Silva, Roberta Baradel, Raquel Fornari, Patrícia Vanzella, Katerina Lukasova, and Maria Carthery Goulart. "EFFICACY OF COGNITIVE TRAINING FOCUSED ON DIFFERENT MEMORY SUBSYSTEMS FOR COMMUNITY DWELLING ELDERLY INDIVIDUALS." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda105.

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Background: With the aging process, some memory subsystems as the episodic and working memory change. Cognitive training has been suggested for prevention of cognitive decline but previous studies have conflicting results. Objective: To verify the efficacy of two types of multidimensional cognitive training programs, one focusing on internal strategies to boost episodic memory (EMT) and another based on activities targeting speed processing and working memory (WMT). Methods: One hundred thirty six community dwelling older adults (aged 60 or over and living independently) took part in the study, 76 undertook EMT, 30 undertook WMT and 30 participated in a control program that focused on autobiographical memory (AMT). Training occurred during 8 weekly group sessions of 1,5h. All groups participated in lectures about cognition and aging during the training. They received activities to practice at home. A neuropsychological battery was applied before and after the interventions. Results: ANOVA of repeated measures pointed to significant higher scores in global cognition (ACER), their memory subtest, and in recall score of categorized noun pictures. The interaction showed that the episodic group improved more than the others in the recall of pictures (interaction between group and task p <0,01). Conclusion: The results demonstrated immediate gains after training in specific episodic memory trained skills.
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Palma, Giovanni, Mariana Lima, Clarisse Friedlaender, Celso Furtado, Rodrigo Lasmar, Ana Carolina Rodrigues, and Paulo Caramelli. "SOCCER HEADING AND COGNITIVE PERFORMANCE IN PROFESSIONAL SOCCER PLAYERS: TWO-YEAR LONGITUDINAL DATA." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda098.

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Background: Soccer is the most popular sport worldwide, in which players purposely hit the ball with the head. Although researchers have focused on the effects of concussions in contact sports, the role of sub-concussive impacts (e.g., heading) has gained attention. Objective: To investigate the effects of soccer heading on cognitive functioning in active soccer players. Methods: Male professional soccer players (n=9), and non-athletes (n=25), matched by age and education, were submitted to computerized cognitive tests and to the Neupsilin. All subjects were tested on two occasions – T0 and T2 – separated by two years. Results: Intragroup analyses revealed that while controls improved their performance in 11 variables from T0 to T2, soccer players only improved in one test. However, controls had a worst performance in two variables. In T2, players performed better in the immediate memory test. Among players, no significant correlations were found between number of headings per game and cognition in T0 and T2. Conclusion: There was no evidence of cognitive impairment in soccer players in T0 and T2. They even outperformed controls in some tests. However, the improvement (probable learning effect) observed from T0 to T2 in controls was consistent over the players unvarying performance. Further investigations are needed to clarify relationships between soccer heading and cognition.
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Lacerda, Isabel, Raquel Santos, Tatiana Belfort, José Neto, and Marcia Dourado. "DOMAINS OF AWARENESS WITH COMPLEX JUDGEMENTS ARE ASSOCIATED TO EXECUTIVE FUNCTION IN ALZHEIMER’ DISEASE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda049.

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Background: Awareness is a multidimensional construct and there is a lack of research investigating the association between awareness domains and other deficits than cognition. Objective: Our aim is to investigate the influence of executive dysfunction in awareness domains. Methods: 75 people with mild-to-moderate AD completed assessments about global cognitive function, executive functioning, and their awareness of disease. Their primary caregivers’ dyad provided information about demographics, awareness of disease, dementia severity, neuropsychiatric symptoms, and functional status. Results: Executive dysfunction was predictor for more complex domains of awareness: awareness of disease, of emotional state and of social functioning and relationships. Awareness of cognitive functioning and health condition and of functional activity impairments exhibit only global cognitive function as a predictor. Conclusions: Findings confirm some degree of independence between awareness domains and identify the more complexity of some domains beside others. These results suggest that different interventions are necessary in domains of awareness.
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Almeida, Mariana, Paulo Caramelli, Maira Barbosa, Ana Paula Santos, and Karolina Carmona. "ALCOHOL CONSUMPTION AND COGNITIVE AND FUNCTIONAL PERFORMANCE IN OLDER ADULTS AGED 75+ YEARS: THE PIETÀ STUDY." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda034.

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Introduction: The relationship between alcohol and cognition is complex. Objective: To investigate the association of alcohol consumption with cognitive impairment, functionality, psychiatric and neurological diagnoses. Methods: Cross-sectional population-based study. 602 subjects 75+ years were categorized according to the number of drinks consumed per week: 0 (abstainers); 0.1 to 7 (light); 7.1 to 14 (moderate); > 14 (heavy). Cognitive diagnoses were established: dementia, cognitive impairment no dementia (CIND) and without cognitive impairment. Results: On multivariate analysis there was no association between cognitive profile and current or previous alcohol consumption. When previous alcohol consumption was treated as dichotomous variable, no association emerged with cognitive profile (p=0.109). As for current habit of alcohol intake treated as dichotomous variable, the absence of alcohol consumption was associated with dementia (OR=2.34; 95%CI: 1.39- 3.90), stroke (p=0.014), current major depression (p=0.013), parkinsonism (p=0.041) and worse functionality (p=0.001). Cachaça consumption was associated with dementia (OR=2.52; 95%CI: 1.25-5.04). Conclusion: Absence of current alcohol consumption was associated with diagnosis of dementia, stroke, major depression, parkinsonism and worse functionality. On the other hand, intake of cachaça was associated with dementia.
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Lucena, Aline De, Paulo Fernando Santos, and Marcia Cristina Dourado. "AFFECTIVE THEORY OF MIND IN PEOPLE WITH ALZHEIMER’S DISEASE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda052.

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Background: In recent years, interest has been growing in cognitive and affective ToM functioning in individuals suffering from neurodegenerative disorders, such as Alzheimer’s disease (AD). However, the affective ToM has been less investigated. Objective: This study aims to compare affective ToM performance in persons with mild to moderate AD and healthy older controls (HOC), and its relationship with cognition. Methods: A cross-sectional study of 97 mild to moderate AD individuals and 40 HOC. To assess affective ToM, participants were administered a task that examines ability to comprehend the emotional situation nature along with the appropriate emotional state that one would experience in that situation. Assessments of cognition, dementia severity, functionality, awareness of disease and neuropsychiatric symptoms were completed for AD group. Results: Analyses of emotional reasoning indicated a group effect on performance. There was a significant difference between the AD and HOC groups in terms of their ability to understand situations of sadness, surprise, anger, and happiness, with the moderate AD showing the worst performance for all emotional situations. Ability to appropriately name the emotional state was significantly different for surprise, anger, and happiness, but not for sadness, with both AD groups showing lower performance for surprise and anger, and with the mild AD showing better performance for happiness. In both AD groups, ability to understand the emotional situation and to name the emotion was significantly correlated with cognitive impairment and awareness of disease. Neuropsychiatric symptoms were significantly correlated in moderate AD group. Conclusions: Impairment in understanding the emotional aspects of situations can lead moderate AD people to experience conflicts in family and social situations. Mild AD people can experience same conflicts when their preserved ability in understanding the emotional situation is underestimated.
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Souza, João Pedro Ferrari, Wagner Brum, Lucas Hauschild, Lucas Da Ros, Pâmela Lukasewicz Ferreira, Bruna Bellaver, Douglas Leffa, et al. "ASSOCIATION OF VASCULAR RISK AND ALZHEIMER’S DISEASE PATHOLOGY WITH NEURODEGENERATION AND COGNITIVE DECLINE." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda024.

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Background: It is not fully understood how vascular risk factors (VRFs) are associated with Alzheimer’s disease (AD) pathology to promote neurodegeneration and cognitive decline. Objective: Investigate whether VRF burden synergistically interacts with AD pathology to accelerate neurodegeneration and cognitive decline in cognitively unimpaired (CU) individuals. Methods: We assessed 503 CU participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Individuals were dichotomized as having an elevated VRF burden if ≥ 2 VRFs (V+) and as presenting biological AD if CSF p-tau181 ≥ 24 pg/mL and CSF Aβ1-42 ≤ 976.6 pg/mL [(AT)+]. Neurodegeneration was assessed with plasma neurofilament light (NfL) and cognition with the modified version of the Preclinical Alzheimer’s Cognitive Composite. Results: Linear mixed-effects models demonstrated that an elevated VRF burden interacted with AD pathology to promote higher rates of neurodegeneration (β=5.68, p=.005) and cognitive decline (β=- 0.43, p=.019). Survival analysis demonstrated that only (AT)+V+ individuals had a significantly greater risk of clinical progression to cognitive impairment (adjusted Hazard Ratio=3.5, p <.001). Conclusion: Our results suggest that VRF burden and AD pathology synergistically lead to neurodegeneration and cognitive decline, favoring the onset of cognitive impairment. These findings support that the clinical evaluation of VRF burden might improve the clinical assessment especially of subjects at higher risk for developing cognitive impairment.
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Baptista, Maria Alice, Nathália Kimura, Isabel Lacerda, Felipe Silva, and Marcia Cristina Dourado. "YOUNG AND LATE ONSET DEMENTIA: HOW DO THEY DIFFER IN TERMS OF DOMAINS OF AWARENESS?" In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda042.

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Background: Young onset dementia (YOD) is a diagnosis given when the neurocognitive process sets in before 65 years age. The YOD dementia process poses specific challenges related to financial issues, work and social demands, marriage, and parenthood, including losses and shifting roles, care responsibilities, as well as prospects for the future. Those challenges might account for the difference in awareness between YOD and late onset dementia (LOD). Awareness can be defined as the recognition of changes caused by deficits related to the disease process, which may include the ability to recognize a specific deficit, the emotional response to the difficulties presented and the ability to understand the impact of the disease in activities of daily living Objectives: This study is designed to investigate differences in awareness of cognitive functioning and health condition, functional activity impairments, emotional state, and social functioning and relationships among people with young onset (YOD) and late onset dementia (LOD); and examine associations between awareness and its domains with cognition, functionality, neuropsychiatric symptoms, social and emotional functioning and quality of life (QoL) in both groups. Methods: This is a cross-sectional design study. A group of 136 people with dementia and their respective caregivers (YOD = 50 and LOD = 86) were consecutively selected from an Alzheimer’s disease outpatient unit in Rio de Janeiro, Brazil. We assessed awareness of disease, dementia severity, cognition, functionality, neuropsychiatric symptoms, social and emotional functioning, and quality of life. Results: People with YOD were more aware of disease (total score), more aware of their cognitive functioning and health condition and of their functional activity impairments than people with LOD, even if this group was more severely cognitive impaired and had a worse level of functionality than LOD group. Besides, people with YOD had more neuropsychiatric symptoms than people with LOD. Multivariate linear regressions showed that functionality has a wide relationship to awareness for people with YOD. While neuropsychiatric symptoms and quality of life has a greater relation to awareness for people with LOD. Conclusions Different clinical variables are associated to different domains in YOD and LOD groups, reinforcing the heterogeneity of awareness in dementia.
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Reports on the topic "Cognition disorders"

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Madu, Laura, Jacqueline Sharp, and Bobby Bellflower. Efficacy of Integrating CBT for Mental Health Care into Substance Abuse Treatment in Patients with Comorbid Disorders of Substance Abuse and Mental Illness. University of Tennessee Health Science Center, April 2021. http://dx.doi.org/10.21007/con.dnp.2021.0004.

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Abstract: Multiple studies have found that psychiatric disorders, like mood disorders and substance use disorders, are highly comorbid among adults with either disorder. Integrated treatment refers to the treatment of two or more conditions and the use of multiple therapies such as the combination of psychotherapy and pharmacotherapy. Integrated therapy for comorbidity per numerous studies has consistently been superior to the treatment of individual disorders separately. The purpose of this QI project was to identify the effectiveness of Cognitive Behavioral Therapy (CBT) instead of current treatment as usual for treating Substance Use Disorder (SUD) or mental health diagnosis independently. It is a retrospective chart review. The review examines CBT's efficacy for engaging individuals with co-occurring mood and substance u se disorders in treatment by enhancing adherence and preventing disengagement and relapse. Methods: Forty adults aged 26-55 with a DSM-IV diagnosis of a mood disorder of Major Depressive Disorder and/or anxiety and concurrent substance use disorder (at least weekly use in the past month). Participants received 12 sessions of individual integrated CBT treatment delivered with case management over a 12-week period. Results: The intervention was associated with significant improvements in mood disorder, substance use, and coping skills at 4, 8, and 12 weeks post-treatment. Conclusions: These results provide some evidence for the effectiveness of the integrated CBT intervention in individuals with co-occurring disorders. Of note, all psychotherapies are efficacious; however, it would be more advantageous to develop a standardized CBT that identifies variables that facilitate treatment outcomes specifically to comorbid disorders of substance use and mood disorders. It is concluded that there is potentially more to be gained from further studies using randomized controlled designs to determine its efficacy.
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Dyulicheva, Yulia Yu, Yekaterina A. Kosova, and Aleksandr D. Uchitel. he augmented reality portal and hints usage for assisting individuals with autism spectrum disorder, anxiety and cognitive disorders. [б. в.], November 2020. http://dx.doi.org/10.31812/123456789/4412.

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The augmented reality applications are effectively applied in education and therapy for people with special needs. We propose to apply the augmented reality portal as a special tool for the teachers to interact with people at the moment when a panic attack or anxiety happens in education process. It is expected that applying the augmented reality portal in education will help students with ASD, ADHD and anxiety disorder to feel safe at discomfort moment and teachers can interact with them. Our application with the augmented reality portal has three modes: for teachers, parents, and users. It gives the ability to organize personalized content for students with special needs. We developed the augmented reality application aimed at people with cognitive disorders to enrich them with communication skills through associations understanding. Applying the augmented reality application and the portal discovers new perspectives for learning children with special needs. The AR portal creates illusion of transition to another environment. It is very important property for children with ADHD because they need in breaks at the learning process to change activity (for example, such children can interact with different 3D models in the augmented reality modes) or environment. The developed AR portal has been tested by a volunteer with ASD (male, 21 years old), who confirmed that the AR portal helps him to reduce anxiety, to feel calm down and relaxed, to switch attention from a problem situation.
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Stuart, Nicole, Karina Dorrington, Andrew Sheridan, and Carmela Pestell. The Neuropsychological Correlates of Sluggish Cognitive Tempo: A Systematic Review Protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0102.

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Review question / Objective: The objective the current review is to delineate the cognitive profile of SCT, particularly where it is similar to or different from ADHD-related inattention. In addition, the review will provide an analysis of methodological factors that might account for discrepancies in research findings and guidance for future studies. Condition being studied: Sluggish cognitive tempo (SCT) is a constellation of symptoms originally identified among children with the inattentive subtype of attention deficit hyperactivity disorder (ADHD-I). These symptoms include daydreaming, inconsistent alertness, hypoactivity and lethargy. Although there is considerable overlap with ADHD-I, factor analytic and convergent and discriminant validity studies suggest that SCT is a distinct construct. Moreover, there is evidence that SCT may be common in a number of other disorders, including depression and autism - suggesting that SCT might represent an important transdiagnostic construct.
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Ylvisaker, Mark. Rehabilitation of Children and Adults With Cognitive-Communication Disorders After Brain Injury. Rockville, MD: American Speech-Language-Hearing Association, 2003. http://dx.doi.org/10.1044/policy.tr2003-00146.

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Minshew, Nancy J., and Shaun M. Eack. A Randomized Clinical Trial of Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorders. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada612297.

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Minshew, Nancy J., and Shaun M. Each. A Randomized Clinical Trial of Cognitive Enhancement Therapy for Adults with Autism Spectrum Disorders. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada582498.

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Robledo-Castro, Carolina, Gisella Bonilla-Santos, and Piedad Rocío Lerma-Castaño. Computer-based cognitive training programs: effects on executive functions in children with attention deficit hyperactivity disorder (ADHD). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0046.

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Review question / Objective: This systematic review aimed to synthesize the existing literature reporting the effects of computer-based cognitive training on the executive functions of children with ADHD. Condition being studied: Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder diagnosed in childhood, characterized by a persistent pattern of inattention, hyperactivity, and impulsivity. Today it is recognized that ADHD is associated with an alteration in the volume and level of activation in prefrontal areas related to executive functions. Based on these clinical findings, some authors suggest that ADHD is not a disorder of primary attention origin but instead responds to an alteration in the synaptic circuits of some brain areas, including the prefrontal neocortex, areas involved in cognitive regulation and control, and processes known as executive functions.
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Osadchyi, Viacheslav V., Hanna B. Varina, Kateryna P. Osadcha, Olesia O. Prokofieva, Olha V. Kovalova, and Arnold E. Kiv. Features of implementation of modern AR technologies in the process of psychological and pedagogical support of children with autism spectrum disorders. [б. в.], November 2020. http://dx.doi.org/10.31812/123456789/4413.

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The article deals with the actual issue of the specificity and algorithm of the introduction of innovative AR technologies in the process of psychological and pedagogical support of children with autism spectrum disorders (ASD). An innovative element of theoretical and methodological analysis of the problem and empirical research is the detection of vectors of a constructive combination of traditional psycho-correctional and psycho-diagnostic approaches with modern AR technologies. The analysis of publications on the role and possibilities of using AR technologies in the process of support children with ASD (autism spectrum disorder) and inclusive environment was generally conducted by surfing on the Internet platforms containing the theoretical bases for data publications of scientific journals and patents. The article also analyzes the priorities and potential outcomes of using AR technologies in psycho-correction and educational work with autistic children. According to the results of the analysis of scientific researches, Unified clinical protocol of primary, secondary (specialized), tertiary (highly specialized) medical care and medical rehabilitation “Autism spectrum disorders (disorders of general development)”, approaches for correction, development and education of children with ASD, AR technologies were selected for further implementation in a comprehensive program of psychological and pedagogical support for children with ASD. The purpose of the empirical study is the search, analysis and implementation of multifunctional AR technologies in the psycho-correctional construct of psychological and pedagogical support of children with ASD. According to the results of the pilot study, the priorities and effectiveness of using AR technologies in the development of communicative, cognitive, emotional-volitional, mnemonic abilities of children and actualization of adaptive potential and adaptive, socially accepted behaviors are made. The possibilities and perspectives of using AR technologies as an element of inclusive environment, with regard to nosology and phenomenology, need further investigation.
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Hu, Yang Yang, Xing Zhang, Yue Luo, and Yadong Wang. Systematic review and Meta analysis of the efficacy and safety of rifaximin in the prevention and treatment of hepatic encephalopathy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2023. http://dx.doi.org/10.37766/inplasy2023.2.0061.

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Review question / Objective: P：Liver cirrhosis patients with risk factors associated with HE attack;HE patients caused by chronic liver diseases represented by cirrhosis. I: Rifaximin treatment. C: Other drugs or placebo. O：HE incidence; HE improvement; All-cause mortality; Blood ammonia level; PSE index; mental state; NCT-A; NCT-B; Adverse events. Condition being studied: Hepatic encephalopathy(HE) is a neuropsychiatric disorder syndrome based on metabolic disorders, which is caused by severe acute and chronic liver dysfunction or various abnormalities of portosystemic shunt (hereinafter referred to as portosystemic shunt). The research data shows that the prevalence of OHE in patients with cirrhosis is 10-14%, and the prevalence of HE in patients with decompensated cirrhosis is 16-21%. HE can lead to 60-80% of patients with liver cirrhosis with mild cognitive impairment, affecting their ability of daily life and quality of life. When OHE occurs, the one-year mortality rate of patients with liver cirrhosis is 64%, which brings a heavy economic burden to patients and public health resources. Therefore, the prevention and early management of HE is very important.
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Holloway, Marjan G. Pilot Trial of Inpatient Cognitive Therapy for the Prevention of Suicide in Military Personnel with Acute Stress Disorder or Post-Traumatic Stress Disorder. Fort Belvoir, VA: Defense Technical Information Center, August 2013. http://dx.doi.org/10.21236/ada594615.

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