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Relevant bibliographies by topics / COCHLEAR PROGENITORS

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Journal articles
Dissertations / Theses
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Academic literature on the topic 'COCHLEAR PROGENITORS'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "COCHLEAR PROGENITORS"

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Udagawa, Tomokatsu, Patrick J. Atkinson, Beatrice Milon, et al. "Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration." PLOS Biology 19, no. 11 (2021): e3001445. http://dx.doi.org/10.1371/journal.pbio.3001445.

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Cochlear supporting cells (SCs) are glia-like cells critical for hearing function. In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has been shown to nonmitotically regenerate SCs. Here, we ablated Lgr5+ SCs using Lgr5-DTR mice and found mitotic regeneration of SCs by GER cells in vivo. With lineage tracing, we show that the GER houses progenitor cells that robustly divide and migrate into the organ of Corti to replenish ablated SCs. Regenerated SCs display coordinated calcium transients, markers of the SC subtype inner phalangea

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Li, Xiao-Jun, and Angelika Doetzlhofer. "LIN28B/let-7control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling." Proceedings of the National Academy of Sciences 117, no. 36 (2020): 22225–36. http://dx.doi.org/10.1073/pnas.2000417117.

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Mechano-sensory hair cells within the inner ear cochlea are essential for the detection of sound. In mammals, cochlear hair cells are only produced during development and their loss, due to disease or trauma, is a leading cause of deafness. In the immature cochlea, prior to the onset of hearing, hair cell loss stimulates neighboring supporting cells to act as hair cell progenitors and produce new hair cells. However, for reasons unknown, such regenerative capacity (plasticity) is lost once supporting cells undergo maturation. Here, we demonstrate that the RNA binding protein LIN28B plays an im

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Munnamalai, Vidhya, Nabilah H. Sammudin, Caryl A. Young, Ankita Thawani, Richard J. Kuhn, and Donna M. Fekete. "Embryonic and Neonatal Mouse Cochleae Are Susceptible to Zika Virus Infection." Viruses 13, no. 9 (2021): 1823. http://dx.doi.org/10.3390/v13091823.

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Congenital Zika Syndrome (CZS) is caused by vertical transmission of Zika virus (ZIKV) to the gestating human fetus. A subset of CZS microcephalic infants present with reduced otoacoustic emissions; this test screens for hearing loss originating in the cochlea. This observation leads to the question of whether mammalian cochlear tissues are susceptible to infection by ZIKV during development. To address this question using a mouse model, the sensory cochlea was explanted at proliferative, newly post-mitotic or maturing stages. ZIKV was added for the first 24 h and organs cultured for up to 6 d

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Lin, Jizhen, Ling Feng, Shinji Fukudome, Yuki Hamajima, Tina Huang, and Samuel Levine. "Cochlear Stem Cells/Progenitors and Degenerative Hearing Disorders." Current Medicinal Chemistry 14, no. 27 (2007): 2937–43. http://dx.doi.org/10.2174/092986707782360051.

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5

Feng, Ling. "Differentiation of cochlear neural progenitors with SV40 in vitro." Molecular and Cellular Pharmacology 1, no. 1 (2009): 11–22. http://dx.doi.org/10.4255/mcpharmacol.09.03.

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Lin, Jizhen, Ling Feng, Yuki Hamajima, et al. "Directed differentiation of mouse cochlear neural progenitors in vitro." American Journal of Physiology-Cell Physiology 296, no. 3 (2009): C441—C452. http://dx.doi.org/10.1152/ajpcell.00324.2008.

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Multipotent cochlear neural progenitors (CNPs) in the organ of Corti hold the promise for cell replacement in degenerative hearing disorders. However, not much is known about the CNPs and the specific conditions for their differentiation. Here we isolate the CNPs from the postnatal day 1 organ of Corti in mice and demonstrate their capability to self-renew and to differentiate into hair cell-like and neuronal cell-like phenotypes under the guidance of sonic hedgehog (SHH), epidermal growth factor (EGF), retinoic acid (RA), and brain-derived neurotrophic factor (BDNF), herein termed SERB (abbre

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Otsuka, Kelly S., Christopher Nielson, Matthew A. Firpo, Albert H. Park, and Anna E. Beaudin. "Early Life Inflammation and the Developing Hematopoietic and Immune Systems: The Cochlea as a Sensitive Indicator of Disruption." Cells 10, no. 12 (2021): 3596. http://dx.doi.org/10.3390/cells10123596.

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Emerging evidence indicates that perinatal infection and inflammation can influence the developing immune system and may ultimately affect long-term health and disease outcomes in offspring by perturbing tissue and immune homeostasis. We posit that perinatal inflammation influences immune outcomes in offspring by perturbing (1) the development and function of fetal-derived immune cells that regulate tissue development and homeostasis, and (2) the establishment and function of developing hematopoietic stem cells (HSCs) that continually generate immune cells across the lifespan. To disentangle t

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8

Kwan, Kelvin Y., and Patricia M. White. "Understanding the differentiation and epigenetics of cochlear sensory progenitors in pursuit of regeneration." Current Opinion in Otolaryngology & Head & Neck Surgery 29, no. 5 (2021): 366–72. http://dx.doi.org/10.1097/moo.0000000000000741.

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9

Breuskin, Ingrid, Morgan Bodson, Nicolas Thelen, et al. "Sox10 promotes the survival of cochlear progenitors during the establishment of the organ of Corti." Developmental Biology 335, no. 2 (2009): 327–39. http://dx.doi.org/10.1016/j.ydbio.2009.09.007.

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10

Gnedeva, Ksenia, Xizi Wang, Melissa M. McGovern, et al. "Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal." Proceedings of the National Academy of Sciences 117, no. 24 (2020): 13552–61. http://dx.doi.org/10.1073/pnas.2000175117.

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Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium—the organ of Corti—progenitor cells exit the cell cycle in a coordinated wave between E12.5 and E14.5 before the initiation of sensory receptor cell differentiation, making it a unique system for studying the molecular mechanisms controlling the switch between proliferation and differentiation. Here we identify the Yap/Tead complex as a key regulator of the self-renewal gene network in organ of Corti progenitor cells. We sho

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Dissertations / Theses on the topic "COCHLEAR PROGENITORS"

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BRUNO, MARINA. "ROLE OF BIOACTIVE SPHINGOLIPIDS IN INNER EAR AND SKELETAL MUSCLE BIOLOGY." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072579.

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Sphingolipids are a class of complex lipids known to be not only structural components of biological membranes, but also bioactive molecules involved in several processes, such as cell differentiation, proliferation, motility and cell survival. Between them, we focused on sphingosine 1-phosphate (S1P) and ceramide 1-phosphate (C1P). S1P is intracellularly produced by sphingosine kinase (SK) 1 and SK2 and exerts many of its action consequently to its ligation to S1P specific receptors (S1PR), S1P1–5, whereas C1P is generated by the action of ceramide kinase and it is able to via activation of d

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2

Nishimura, Koji. "Transplantation of murine induced pluripotent stem cell-derived neural progenitors into the cochlea." Kyoto University, 2012. http://hdl.handle.net/2433/157416.

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Book chapters on the topic "COCHLEAR PROGENITORS"

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Lin, Jizhen, Water Low, and Catherine Verfaillie. "Cochlear Stem Cells/Progenitors." In Stem Cells and Regenerative Medicine. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812775771_0013.

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