Academic literature on the topic 'Cochlea – Physiology'

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Journal articles on the topic "Cochlea – Physiology"

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Robles, Luis, and Mario A. Ruggero. "Mechanics of the Mammalian Cochlea." Physiological Reviews 81, no. 3 (2001): 1305–52. http://dx.doi.org/10.1152/physrev.2001.81.3.1305.

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In mammals, environmental sounds stimulate the auditory receptor, the cochlea, via vibrations of the stapes, the innermost of the middle ear ossicles. These vibrations produce displacement waves that travel on the elongated and spirally wound basilar membrane (BM). As they travel, waves grow in amplitude, reaching a maximum and then dying out. The location of maximum BM motion is a function of stimulus frequency, with high-frequency waves being localized to the “base” of the cochlea (near the stapes) and low-frequency waves approaching the “apex” of the cochlea. Thus each cochlear site has a c
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Szczepek, Agnieszka J., Tatyana Dudnik, Betül Karayay, Valentina Sergeeva, Heidi Olze, and Alina Smorodchenko. "Mast Cells in the Auditory Periphery of Rodents." Brain Sciences 10, no. 10 (2020): 697. http://dx.doi.org/10.3390/brainsci10100697.

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Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never been documented. In this work, we show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis. The identity of MCs was confirmed in cochlear cryosections and flat preparations using avidin and antibodies against c-Kit/CD117, chymase,
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Köles, László, Judit Szepesy, Eszter Berekméri, and Tibor Zelles. "Purinergic Signaling and Cochlear Injury-Targeting the Immune System?" International Journal of Molecular Sciences 20, no. 12 (2019): 2979. http://dx.doi.org/10.3390/ijms20122979.

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Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology. P2 (ionotropic P2X and the metabotropic P2Y) as well as adenosine receptors expressed on cochlear sensory and non-sensory cells are involved mostly in protective mechanisms of the cochlea. They are implicated in the sensitivity adjustment of the receptor cells by a K
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Delprat, Benjamin, Jérôme Ruel, Matthieu J. Guitton, et al. "Deafness and Cochlear Fibrocyte Alterations in Mice Deficient for the Inner Ear Protein Otospiralin." Molecular and Cellular Biology 25, no. 2 (2005): 847–53. http://dx.doi.org/10.1128/mcb.25.2.847-853.2005.

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ABSTRACT In the cochlea, the mammalian auditory organ, fibrocytes of the mesenchymal nonsensory regions play important roles in cochlear physiology, including the maintenance of ionic and hydric components in the endolymph. Occurrence of human deafness in fibrocyte alterations underlines their critical roles in auditory function. We recently described a novel gene, Otos, which encodes otospiralin, a small protein of unknown function that is produced by the fibrocytes of the cochlea and vestibule. We now have generated mice with deletion of Otos and found that they show moderate deafness, with
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Meenderink, Sebastiaan W. F., and Marcel van der Heijden. "Reverse Cochlear Propagation in the Intact Cochlea of the Gerbil: Evidence for Slow Traveling Waves." Journal of Neurophysiology 103, no. 3 (2010): 1448–55. http://dx.doi.org/10.1152/jn.00899.2009.

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The inner ear can produce sounds, but how these otoacoustic emissions back-propagate through the cochlea is currently debated. Two opposing views exist: fast pressure waves in the cochlear fluids and slow traveling waves involving the basilar membrane. Resolving this issue requires measuring the travel times of emissions from their cochlear origin to the ear canal. This is problematic because the exact intracochlear location of emission generation is unknown and because the cochlea is vulnerable to invasive measurements. We employed a multi-tone stimulus optimized to measure reverse travel tim
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Kikidis, Dimitrios, and Athanasios Bibas. "A Clinically Oriented Introduction and Review on Finite Element Models of the Human Cochlea." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/975070.

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Due to the inaccessibility of the inner ear, direct in vivo information on cochlear mechanics is difficult to obtain. Mathematical modelling is a promising way to provide insight into the physiology and pathology of the cochlea. Finite element method (FEM) is one of the most popular discrete mathematical modelling techniques, mainly used in engineering that has been increasingly used to model the cochlea and its elements. The aim of this overview is to provide a brief introduction to the use of FEM in modelling and predicting the behavior of the cochlea in normal and pathological conditions. I
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Emadi, Gulam, Claus-Peter Richter, and Peter Dallos. "Stiffness of the Gerbil Basilar Membrane: Radial and Longitudinal Variations." Journal of Neurophysiology 91, no. 1 (2004): 474–88. http://dx.doi.org/10.1152/jn.00446.2003.

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Experimental data on the mechanical properties of the tissues of the mammalian cochlea are essential for understanding the frequency- and location-dependent motion patterns that result in response to incoming sound waves. Within the cochlea, sound-induced vibrations are transduced into neural activity by the organ of Corti, the gross motion of which is dependent on the motion of the underlying basilar membrane. In this study we present data on stiffness of the gerbil basilar membrane measured at multiple positions within a cochlear cross section and at multiple locations along the length of th
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Jeong, Sung-Wook, and Lee-Suk Kim. "A New Classification of Cochleovestibular Malformations and Implications for Predicting Speech Perception Ability after Cochlear Implantation." Audiology and Neurotology 20, no. 2 (2015): 90–101. http://dx.doi.org/10.1159/000365584.

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Objectives: The aims of this study were to introduce a new classification of cochleovestibular malformation (CVM) and to investigate how well this classification can predict speech perception ability after cochlear implantation in children with CVM. Methods: Fifty-nine children with CVM who had used a cochlear implant for more than 3 years were included. CVM was classified into 4 subtypes based on the morphology of the cochlea and the modiolus on temporal bone computed tomography (TBCT): normal cochlea and normal modiolus (type A, n = 16), malformed cochlea and partial modiolus (type B, n = 31
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Jones, Timothy A., Sherri M. Jones, and Kristina C. Paggett. "Emergence of Hearing in the Chicken Embryo." Journal of Neurophysiology 96, no. 1 (2006): 128–41. http://dx.doi.org/10.1152/jn.00599.2005.

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It is commonly held that hearing generally begins on incubation day 12 (E12) in the chicken embryo ( Gallus domesticus). However, little is known about the response properties of cochlear ganglion neurons for ages younger than E18. We studied ganglion neurons innervating the basilar papilla of embryos (E12–E18) and hatchlings (P13–P15). We asked first, when do primary afferent neurons begin to encode sounds? Second, when do afferents evidence frequency selectivity? Third, what range of characteristic frequencies (CFs) is represented in the late embryo? Finally, how does sound transfer from air
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Zheng, Jiefu, Chunfu Dai, Peter S. Steyger, et al. "Vanilloid Receptors in Hearing: Altered Cochlear Sensitivity by Vanilloids and Expression of TRPV1 in the Organ of Corti." Journal of Neurophysiology 90, no. 1 (2003): 444–55. http://dx.doi.org/10.1152/jn.00919.2002.

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Capsaicin, the vanilloid that selectively activates vanilloid receptors (VRs) on sensory neurons for noxious perception, has been reported to increase cochlear blood flow (CBF). VR-related receptors have also been found in the inner ear. This study aims to address the question as to whether VRs exist in the organ of Corti and play a role in cochlear physiology. Capsaicin or the more potent VR agonist, resiniferatoxin (RTX), was infused into the scala tympani of guinea pig cochlea, and their effects on cochlear sensitivity were investigated. Capsaicin (20 μM) elevated the threshold of auditory
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Dissertations / Theses on the topic "Cochlea – Physiology"

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Jäger, Wanje. "Physiological aspects of cochlear excitation and neurotransmitter release /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3294-8/.

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Cheng, Jun. "Signal processing approaches on otoacoustic emissions /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4058-4.

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Ku, Emery Mayon. "Modelling the human cochlea." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/64535/.

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One of the salient features of the human cochlea is the incredible dynamic range it possesses—the loudest bearable sound is 10,000,000 times greater than the softest detectable sound; this is in part due to an active process. More than twelve thousand hairlike cells known as outer hair cells are believed to expand and contract in time to amplify cochlear motions. However, the cochlea’s response is more than just the sum of its parts: the local properties of outer hair cells can have unexpected consequences for the global behaviour of the system. One such consequence is the existence of otoacou
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Jaggers, Robert Maxwell. "Is Polyvinylidene diflouride (PVDF) film biocompatible in the Murine Cochlea?" Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1440944212.

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Lennan, George William Thomas. "Mechanoelectrical transduction by hair cells of the neonatal mouse in tissue culture." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296617.

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McMahon, Catherine. "The mechanisms underlying normal spike activity of the primary afferent synapse in the cochlea and its dysfunction : an investigation of the possible mechanisms of peripheral tinnitus and auditory neuropathy." University of Western Australia. School of Biomedical and Chemical Sciences, 2004. http://theses.library.uwa.edu.au/adt-WU2003.0034.

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[Truncated abstract] One of the problems in researching tinnitus is that it has often been assumed that the physiological mechanisms underlying the tinnitus percept cannot be objectively measured. Nonetheless, it is generally accepted that the percept results from altered spontaneous neural activity at some site along the auditory pathway, although it is still debated whether it is produced by: synchronisation of activity of adjacent neurones; a change in the temporal pattern of activity of individual neurones; or an increase in the spontaneous firing rate per se. Similarly, it is possible tha
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O'Beirne, Greg A. "Mathematical modelling and electrophysiological monitoring of the regulation of cochlear amplification." University of Western Australia. School of Biomedical and Chemical Sciences, 2005. http://theses.library.uwa.edu.au/adt-WU2006.0115.

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[Truncated abstract] The cochlea presumably possesses a number of regulatory mechanisms to maintain cochlear sensitivity in the face of disturbances to its function. Evidence for such mechanisms can be found in the time-course of the recovery of CAP thresholds during experimental manipulations, and in observations of slow oscillations in cochlear micromechanics following exposure to low-frequency tones (the “bounce phenomenon”) and other perturbations. To increase our understanding of these oscillatory processes within the cochlea, and OHCs in particular, investigations into cochlear regulatio
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Zagaeski, Mark. "Information processing in the mammalian auditory periphery." Thesis, Boston University, 1991. https://hdl.handle.net/2144/37176.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Inner hair cells (IHC) are the primary sensory cells of the mammalian cochlea. They transduce sound energy into a changing receptor potential which stimulates electrical activity in the Type I spiral ganglion
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Jing, Zhizi Verfasser], Nicola [Akademischer Betreuer] Strenzke, Tobias [Akademischer Betreuer] [Moser, Fred [Akademischer Betreuer] Wolf, and Martin [Akademischer Betreuer] Göpfert. "Sound Encoding in the Mouse Cochlea: Molecular Physiology and Optogenetic Stimulation / Zhizi Jing. Gutachter: Tobias Moser ; Fred Wolf ; Martin Göpfert. Betreuer: Nicola Strenzke." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1050288599/34.

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Markessis, Emily. "Development of an objective procedure allowing frequency selectivity measurements using the masking function of auditory steady state evoked potentials." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209990.

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<u><b>Introduction</u></b><p><p align = "justify">Les surdités cochléaires induisent, outre une audibilité réduite, une série de distorsions de la représentation neurale des sons. Deux des mécanismes à la base de ces distorsions sont d’une part une atteinte de la sélectivité fréquentielle et d’autre part des zones neuro-épithéliales non fonctionnelles. Tant le premier que le second mécanisme apparaissent dans une proportion variable et non prédictible d’un sujet à un autre. Deux tests permettent le diagnostic de ces atteintes spécifiques: la Courbe d’Accord (Tuning Curve: TC) et le Threshold E
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Books on the topic "Cochlea – Physiology"

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Williamstown, Mass ). Mechanics of Hearing Workshop (11th 2011. What fire is in mine ears: Progress in auditory biomechanics : proceedings of the 11th International Mechanics of Hearing Workshop, Williamstown, Massachusetts, 16-22 July 2011 / editors, Christopher A. Shera, Elizabeth S. Olson. American Institute of Physics, 2011.

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service), SpringerLink (Online, ed. Cochlear Mechanics: Introduction to a Time Domain Analysis of the Nonlinear Cochlea. Springer US, 2012.

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F, Grandori, Cianfrone G, and Kemp D. T, eds. Cochlear mechanisms and otoacoustic emissions: 2nd International Symposium on Cochlear Mechanics and Otoacoustic Emissions. Karger, 1990.

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College), NATO Advanced Research Workshop on Auditory Frequency Selectivity (1986 Wolfson. Auditory frequency selectivity. Plenum Press, 1986.

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Harrison, Robert V. The biology ofhearing and deafness. Thomas, 1988.

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The biology of hearing and deafness. Thomas, 1988.

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Compression for clinicians. Singular Pub. Group, 1998.

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Compression for clinicians. 2nd ed. Thomson Delmar, 2006.

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Mechanics, and Biophysics of Hearing (Conference) (1990 University of Wisconsin Madison WI). The Mechanics and biophysics of hearing: Proceedings of a conference held at the University of Wisconsin, Madison, WI, June 25-29, 1990. Springer-Verlag, 1990.

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Salami, Angelo. Neuroplasticity in the auditory brainstem: From physiology to the drug therapy. Nova Science Publishers, 2011.

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Book chapters on the topic "Cochlea – Physiology"

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Adunka, Oliver F. "Physiology of Cochlea." In Encyclopedia of Otolaryngology, Head and Neck Surgery. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_805.

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Pusz, Max, and Philip Littlefield. "Physiology of Cochlear Nerve." In Encyclopedia of Otolaryngology, Head and Neck Surgery. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_806.

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Abbas, Paul J., and Charles A. Miller. "Biophysics and Physiology." In Cochlear Implants: Auditory Prostheses and Electric Hearing. Springer New York, 2004. http://dx.doi.org/10.1007/978-0-387-22585-2_5.

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Schmiedt, Richard A. "The Physiology of Cochlear Presbycusis." In The Aging Auditory System. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0993-0_2.

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Irvine, Dexter R. F. "Cochlear Nucleus: Anatomy and Physiology." In The Auditory Brainstem. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71057-5_4.

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Rhode, William S., and Steven Greenberg. "Physiology of the Cochlear Nuclei." In Springer Handbook of Auditory Research. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2838-7_3.

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Manis, Paul B., John C. Scott, and George A. Spirou. "Physiology of the Dorsal Cochlear Nucleus Molecular Layer." In The Mammalian Cochlear Nuclei. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2932-3_28.

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Vater, Marianne. "Cochlear Physiology and Anatomy in Bats." In Animal Sonar. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-7493-0_20.

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Guinan, John J. "Physiology and Function of Cochlear Efferents." In Encyclopedia of Computational Neuroscience. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7320-6_431-1.

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Kros, Corné J. "Physiology of Mammalian Cochlear Hair Cells." In Springer Handbook of Auditory Research. Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-0757-3_6.

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Conference papers on the topic "Cochlea – Physiology"

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Liu, Shuangqin, Douglas A. Gauthier, Ethan Mandelup, and Robert D. White. "Experimental Investigation of a Hydromechanical Scale Model of the Gerbil Cochlea." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67778.

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In this research, an uncoiled scale gerbil cochlea is designed and fabricated. The cochlea model is an uncoiled, 16 times scale model of the real gerbil cochlea and has only one duct. Both the basilar membrane width and the duct size vary along the length of the device, in analogy to the physiology. The cochlea duct is filled with silicone oil and driven by a modal exciter (shaker) at different frequencies. The movement of the basilar membrane is measured using laser vibrometry at different locations along the basilar membrane. The ratio of the basilar membrane velocity to drive velocity is co
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Rios, Francisco, Raquel Fernandez-Ramos, Jorge Romero-Sanchez, and Jose Francisco Martin. "Corti's organ physiology-based cochlear model: a microelectronic prosthetic implant." In Microtechnologies for the New Millennium 2003, edited by Angel Rodriguez-Vazquez, Derek Abbott, and Ricardo Carmona. SPIE, 2003. http://dx.doi.org/10.1117/12.499032.

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Becker, Sebastian, and Herbert Hudde. "A physiology-based auditory model elucidating the function of the cochlear amplifier and related phenomena. Part II: Model parameters and simulations." In ICA 2013 Montreal. ASA, 2013. http://dx.doi.org/10.1121/1.4799318.

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Hudde, Herbert, and Sebastian Becker. "A physiology-based auditory model elucidating the function of the cochlear amplifier and related phenomena. Part I: Model structure and computational method." In ICA 2013 Montreal. ASA, 2013. http://dx.doi.org/10.1121/1.4798788.

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