Relevant bibliographies by topics / Cochlea – Diseases

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Cochlea – Diseases'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2022

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Journal articles on the topic "Cochlea – Diseases"

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Munnamalai, Vidhya, Nabilah H. Sammudin, Caryl A. Young, Ankita Thawani, Richard J. Kuhn, and Donna M. Fekete. "Embryonic and Neonatal Mouse Cochleae Are Susceptible to Zika Virus Infection." Viruses 13, no. 9 (September 14, 2021): 1823. http://dx.doi.org/10.3390/v13091823.

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Congenital Zika Syndrome (CZS) is caused by vertical transmission of Zika virus (ZIKV) to the gestating human fetus. A subset of CZS microcephalic infants present with reduced otoacoustic emissions; this test screens for hearing loss originating in the cochlea. This observation leads to the question of whether mammalian cochlear tissues are susceptible to infection by ZIKV during development. To address this question using a mouse model, the sensory cochlea was explanted at proliferative, newly post-mitotic or maturing stages. ZIKV was added for the first 24 h and organs cultured for up to 6 days to allow for cell differentiation. Results showed that ZIKV can robustly infect proliferating sensory progenitors, as well as post-mitotic hair cells and supporting cells. Virus neutralization using ZIKV-117 antibody blocked cochlear infection. AXL is a cell surface molecule known to enhance the attachment of flavivirus to host cells. While Axl mRNA is widely expressed in embryonic cochlear tissues susceptible to ZIKV infection, it is selectively downregulated in the post-mitotic sensory organ by E15.5, even though these cells remain infectible. These findings may offer insights into which target cells could potentially contribute to hearing loss resulting from fetal exposure to ZIKV in humans.
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Kim, Sungwook, Ruchire Wijesinghe, Jaeyul Lee, Muhammad Shirazi, Pilun Kim, Jeong Jang, Mansik Jeon, and Jeehyun Kim. "Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization." Electronics 7, no. 8 (July 31, 2018): 133. http://dx.doi.org/10.3390/electronics7080133.

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The precise identification of intra-cochlear microstructures is an essential otorhinolaryngological requirement to diagnose the progression of cochlea related diseases. Thus, we demonstrated an experimental procedure to investigate the most optimal wavelength range, which can enhance the visualization of ex vivo intra-cochlear microstructures using multiple wavelengths (i.e., 860 nm, 1060 nm, and 1300 nm) based optical coherence tomography (OCT) systems. The high-resolution tomograms, volumetric, and quantitative evaluations obtained from Basilar membrane, organ of Corti, and scala vestibule regions revealed complementary comparisons between the aforementioned three distinct wavelengths based OCT systems. Compared to 860 nm and 1300 nm wavelengths, 1060 nm wavelength OCT was discovered to be an appropriate wavelength range verifying the simultaneously obtainable high-resolution and reasonable depth range visualization of intra-cochlear microstructures. Therefore, the implementation of 1060 nm OCT can minimize the necessity of two distinct OCT systems. Moreover, the results suggest that the performed qualitative and quantitative analysis procedure can be used as a powerful tool to explore further anatomical structures of the cochlea for future studies in otorhinolaryngology.
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Sekiya, Tetsuji, Ken Kojima, Masahiro Matsumoto, Matthew C. Holley, and Juichi Ito. "REBUILDING LOST HEARING USING CELL TRANSPLANTATION." Neurosurgery 60, no. 3 (March 1, 2007): 417–33. http://dx.doi.org/10.1227/01.neu.0000249189.46033.42.

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Abstract OBJECTIVE The peripheral auditory nervous system (cochlea and auditory nerve) has a complex anatomy, and it has traditionally been thought that once the sensorineural structures are damaged, restoration of hearing is impossible. In the past decade, however, the potential to restore lost hearing has been intensively investigated using molecular and cell biological techniques, and we can now part with such a pessimistic view. In this review, we examine an important field in hearing restoration research: cell transplantation. METHODS Most efforts in this field have been directed to the replacement of hair cells by transplantation to the cochlea. Here, we focus on transplantation to the auditory nerve, from the side of the cerebellopontine angle rather than the cochlea. RESULTS Delivery of cells to the cochlea is potentially damaging, and nerve cells transplanted distally to the Schwann-glial transitional zone (cochlear side) may become inhibited when they reach the transitional zone. The auditory nerve is probably the most suitable route for cell transplantation. CONCLUSION The auditory nerve occupies an important position not only in neurosurgery but also in various diseases in other disciplines, and several lines of recent evidence indicate that it is a key target for hearing restoration. It is familiar to most neurosurgeons, and the recent advances in the molecular and cell biology of inner-ear development are of direct importance to neurorestorative medicine. In this article, we review the anatomy, development, and molecular biology of the auditory nerve and cochlea, with emphasis on the advances in cell transplantation.
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Jackler, Robert K., and William P. Dillon. "Computed Tomography and Magnetic Resonance Imaging of the Inner Ear." Otolaryngology–Head and Neck Surgery 99, no. 5 (November 1988): 494–504. http://dx.doi.org/10.1177/019459988809900508.

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The majority of temporal bone radiographic studies are obtained either for middle ear and mastoid disease or in the evaluation of retrocochlear pathology. With recent technologic advances, diagnostic imaging of the inner ear has developed an increasing role in the evaluation and management of diseases that affect the cochlea, semicircular canals, and the vestibular and cochlear aqueducts. High-resolution computed tomography (CT) provides excellent detail of the osseous labyrinth, whereas magnetic resonance imaging (MRI) generates images derived from the membranous labyrinth and its associated neural elements. Optimal techniques for obtaining high quality CT and MRI images of the normal and diseased inner ear are presented. CT has proved useful in the evaluation of inner ear malformations, cochlear otosclerosis, labyrinthine fistulization from cholesteatoma, translabyrinthine fractures, otic capsule osteodystrophies, in the assessment of cochlear patency before cochlear implantation, and in the localization of prosthetic devices such as stapes wires and cochlear implants. While MRI produces discernible images of the soft tissue and fluid components of the inner ear, it has yet to demonstrate any unique advantages in the evaluation of inner ear disease. However, MRI produces excellent and highly useful images of the audiovestibular and facial nerves, cerebellopontine angle, and brain.
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Guo, Weiwei, Haijin Yi, Zhang Yan, Lili Ren, Lei Chen, Li Dong Zhao, Yu Ning, David Z. Z. He, and Shi-Ming Yang. "The morphological and functional development of the stria vascularis in miniature pigs." Reproduction, Fertility and Development 29, no. 3 (2017): 585. http://dx.doi.org/10.1071/rd15183.

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The purpose of this study was to examine the morphological and functional development of the lateral wall of the scala media of the cochlea in miniature pigs; light and transmission electron microscopy and electrophysiology were used for this purpose. We showed that the lateral wall of the scala media of the cochlea appears at embryonic Day 21 (E21) when the cochlear duct begins to form. From E28 to E49, the lateral wall can be distinguished according to its position along the cochlea. At E56, cells in the lateral wall begin to differentiate into three different types. At E70, three cell types, marginal, intermediate and basal, can be clearly distinguished. At E91, the stria vascularis is adult-like and the organ of Corti is also morphologically mature. The average endocochlear potential measured from the second turn of the cochlea (at E98, postnatal Day 1 (P1), P13 and P30) was 71.4 ± 2.5 (n = 7), 78.8 ± 1.5 (n = 10), 77.3 ± 2.3 (n = 10) and 78.0 ± 2.1 mV (n = 10), respectively. Our results suggest that in miniature pigs the stria vascularis develops during the embryonic period, concurrent with maturation of the organ of Corti. The magnitude of the endocochlear potential reached its mature level when the stria vascularis was morphologically adult-like at E98. These findings provide a morphological and functional basis for future animal studies using the miniature pig model concerning the pathogenesis of various inner-ear diseases.
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Engel, Frank, Rosemarie Blatz, Reinhard Schliebs, Michael Palmer, and Sucharit Bhakdi. "Bacterial Cytolysin Perturbs Round Window Membrane Permeability Barrier In Vivo: Possible Cause of Sensorineural Hearing Loss in Acute Otitis Media." Infection and Immunity 66, no. 1 (January 1, 1998): 343–46. http://dx.doi.org/10.1128/iai.66.1.343-346.1998.

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ABSTRACT The passage of radioiodinated streptolysin-O (SLO) and albumin through the round window membrane (RWM) was studied in vivo. When applied to the middle ear, SLO became quantitatively entrapped in this compartment and no passage to the cochlea occurred. However, flux of radioiodinated albumin through the toxin-damaged RWM was observed. We propose that the passage of noxious macromolecules, such as proteases, from a purulent middle-ear effusion may be facilitated by pore-forming toxins, resulting in cochlear damage and sensorineural hearing loss.
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Sillman, Jonathon S., Michael J. Larouere, Alfred L. Nuttall, Merle Lawrence, and Josef M. Miller. "Recent Advances in Cochlear Blood Flow Measurements." Annals of Otology, Rhinology & Laryngology 97, no. 1 (January 1988): 1–8. http://dx.doi.org/10.1177/000348948809700101.

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Changes in blood flow to the inner ear have been thought to influence or underlie a number of cochlear diseases, including some forms of noise-induced hearing loss, sudden hearing loss, and Meniere's disease. Recently, important advances have been made in two technologies for the study of cochlear blood flow. The first is in the area of vital microscopic studies of cochlear microcirculation, and the second is based on the introduction of laser technology in the form of laser Doppler flowmetry. In this report, measurements are given of changes in cochlear circulation caused by carbon dioxide breathing, intravenous phenylephrine injection, systemic hemodilution, positive end expiratory pressure, and direct electrical stimulation of the cochlea. From these changes, we observe that cochlear blood circulation responds to systemic blood pressure alterations and is subject to local flow control mechanisms. Linearity and speed of response of the laser Doppler instrumentation also are shown. These advances show promise for contributing to our knowledge of control mechanisms of inner ear blood flow and for revealing the influence of various pharmacologic agents of potential clinical value.
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Su, Zhongwu, Hao Xiong, Jiaqi Pang, Hanqing Lin, Lan Lai, Huasong Zhang, Weijian Zhang, and Yiqing Zheng. "LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss." Oxidative Medicine and Cellular Longevity 2019 (October 27, 2019): 1–13. http://dx.doi.org/10.1155/2019/6150148.

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Long noncoding RNA (lncRNA) disorder has been found in many kinds of age-associated diseases. However, the role of lncRNA in the development of age-related hearing loss (AHL) is still largely unknown. This study sought to uncover AHL-associated lncRNAs and the function. RNA-sequencing was conducted to profile lncRNA expression in the cochlea of an early-onset AHL mouse model. RT-qPCR assay was used to validate the expression pattern of lncRNAs. ATP assay, JC-1 assay, mitochondrial probe staining, CCK-8 assay, Western blot, and immunocytochemistry were performed to detect the effects of lncRNA AW112010 in HEI-OC1 cells and the mouse cochlea. We identified 88 significantly upregulated lncRNAs and 46 significantly downregulated lncRNAs in the cochlea of aged C57BL/6 mice. We focused on the significantly upregulated AW112010. Silencing of AW112010 decreased the ATP level, mitochondrial membrane potential, and cell viability and increased mitochondrial ROS generation under oxidative stress in HEI-OC1 cells. AW112010 overexpression promoted cell survival in HEI-OC1 cells. AW112010 knockdown reduced mitochondrial mass and impaired mitochondrial biogenesis in HEI-OC1 cells. Activation of mitochondrial biogenesis by resveratrol and STR1720 promoted cell survival. The mitochondrial biogenesis process was activated in the cochlea of aged mice. Moreover, AW112010 regulated AMPK signaling in HEI-OC1 cells. Transcription factor Arid5b elevated in the aged cochlea and induced AW112010 expression and mitochondrial biogenesis in HEI-OC1 cells. Taken together, lncRNAs are dysregulated with aging in the cochlea of C57BL/6 mice. The Arid5b/AW112010 signaling was induced in the aged mouse cochlea and positively modulated the mitochondrial biogenesis to maintain mitochondrial function.
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Meli, Damian N., Roney S. Coimbra, Dominik G. Erhart, Gerard Loquet, Caroline L. Bellac, Martin G. Täuber, Ulf Neumann, and Stephen L. Leib. "Doxycycline Reduces Mortality and Injury to the Brain and Cochlea in Experimental Pneumococcal Meningitis." Infection and Immunity 74, no. 7 (July 2006): 3890–96. http://dx.doi.org/10.1128/iai.01949-05.

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ABSTRACT Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis. Doxycycline is a clinically used antibiotic with anti-inflammatory effects that lead to reduced cytokine release and the inhibition of MMPs. Here, doxycycline inhibited TACE with a 50% inhibitory dose of 74 μM in vitro and reduced the amount of tumor necrosis factor alpha released into the cerebrospinal fluid by 90% in vivo. In an infant rat model of pneumococcal meningitis, a single dose of doxycycline (30 mg/kg) given as adjuvant therapy in addition to ceftriaxone 18 h after infection significantly reduced the mortality, the blood-brain barrier disruption, and the extent of cortical brain injury. Adjuvant doxycycline (30 mg/kg given subcutaneously once daily for 4 days) also attenuated hearing loss, as assessed by auditory brainstem response audiometry, and neuronal death in the cochlear spiral ganglion at 3 weeks after infection. Thus, doxycycline, probably as a result of its anti-inflammatory properties, had broad beneficial effects in the brain and the cochlea and improved survival in this model of pneumococcal meningitis in infant rats.
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El Ganzoury, Mona M., Terez B. Kamel, Lobna H. Khalil, and A. M. Seliem. "Cochlear Dysfunction in Children following Cardiac Bypass Surgery." ISRN Pediatrics 2012 (July 1, 2012): 1–6. http://dx.doi.org/10.5402/2012/375038.

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Background. Sensorineural hearing loss after procedures including extracorporeal circulation and hypothermia is greater than general population. Mild hypothermia has a protective role on cochlea; however, deep hypothermia may result in cochlear injury. This research aimed at assessing auditory function in children after open heart surgery in relation to different hypothermic techniques. Subjects and Methods. Forty children with acyanotic heart diseases who underwent open heart surgery were included: group I: twenty patients subjected to mild hypothermia (33° to 37°C), group II: twenty patients subjected to moderate hypothermia (28° to 32°C). Audiological assessment included basic evaluation and otoacoustic emissions. Results. Both groups had distortion-product otoacoustic emissions (DPOAEs) amplitude >3 dB SPL at all frequencies. However, group II showed lower amplitude at overall and at high frequencies (4.416–8.837 KHz) than group I. Transient evoked otoacoustic emissions (TEOAEs) showed partial pass in three patients of group I (15%) and in 15 patients of group II (75%). Moreover, group II showed statistical significant reduction in overall TEOAEs amplitude as well as at high frequencies (2–4 KHz). Conclusions. Patients exposed to moderate hypothermic technique had subtle cochlear dysfunction. Otoacoustic emissions should be used for early detection of subtle cochlear dysfunction in operated cardiac children.
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Dissertations / Theses on the topic "Cochlea – Diseases"

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McMahon, Catherine. "The mechanisms underlying normal spike activity of the primary afferent synapse in the cochlea and its dysfunction : an investigation of the possible mechanisms of peripheral tinnitus and auditory neuropathy." University of Western Australia. School of Biomedical and Chemical Sciences, 2004. http://theses.library.uwa.edu.au/adt-WU2003.0034.

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[Truncated abstract] One of the problems in researching tinnitus is that it has often been assumed that the physiological mechanisms underlying the tinnitus percept cannot be objectively measured. Nonetheless, it is generally accepted that the percept results from altered spontaneous neural activity at some site along the auditory pathway, although it is still debated whether it is produced by: synchronisation of activity of adjacent neurones; a change in the temporal pattern of activity of individual neurones; or an increase in the spontaneous firing rate per se. Similarly, it is possible that the recently coined “auditory neuropathy” is produced by under-firing of the primary afferent synapse, although several other mechanisms can also produce the symptoms described by this disorder (normal cochlear mechanical function but absent, or abnormal, synchronous neural firing arising from the cochlea and auditory brainstem, known as the auditory brainstem response, or ABR). Despite an absent ABR, some subjects can detect pure tones at near-normal levels, although their ability to integrate complex sounds, such as speech, is severely degraded in comparison with the pure-tone audiogram. The aim of the following study was to investigate the normal mechanisms underlying neural firing at the primary afferent synapse, and its regulation, to determine the possible mechanisms underlying over-firing (tinnitus) or under-firing (auditory neuropathy) of primary afferent neurones.
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Zizz, Carol Anne 1958. "SUPPRESSION OF SPONTANEOUS OTOACOUSTIC EMISSIONS." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276339.

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Mauriac, Stéphanie. "Bases moléculaires de la physiopathologie de la voie de signalisation de la polarité planaire dépendante des protéines Gi." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0080.

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La perte auditive est le trouble sensoriel le plus commun avec 40 % des personnes de plus de 65 ans affectées, entraînant, chez ces patients une dégradation de leur qualité de vie et un isolement sociale. Les principales causes sont le vieillissement ou l'exposition au bruit, mais les mutations génétiques sont aussi à l'origine de déficits auditifs. Parmi ces surdités, le Syndrome de Chudley McCullough (CMCS) est une maladie rare caractérisée par une surdité sévère et précoce associée à des anomalies cérébrales (Chudley et al., 1997). Récemment, des mutations du gène GPSM2 (G protein signaling modulator 2) ont été décrites comme étant responsables de cette pathologie sans que l'on en connaisse les mécanismes (Walsh et al., 2010). A l'aide d'un modèle d'étude murin de cette pathologie, nous avons identifié les bases moléculaires de la pathologie ainsi qu’une nouvelle fonction moléculaire pour Gpsm2 sur la modulation du cytosquelette d’actine. La perturbation de cette fonction affect à la fois la maturation des cellules auditives et la croissance des jeunes neurones, pouvant expliquer les surdités et l’hypoplasie du corps calleux décrits chez ces patients (Mauriac et al., 2017). De plus, nous avons identifié les partenaires de Gpsm2, les protéines Gαi, comme indispensables à la fonction auditive (Beer-Hammer et al., 2018). Au niveau moléculaire, nous avons découvert une nouvelle interaction de Gpsm2 avec une protéine essentielle à la maturation des cellules auditives et impliquées dans les surdités de type Usher, la Whirlin.Par conséquent, notre étude a permis de clarifier l’étiologie du CMCS et de montrer que sa complexité et son aspect multisyndromique sont dus au rôle multifonctionnel du complexe Gpsm2/G⍺i non seulement sur la dynamique de la tubuline dans des cellules en prolifération et en post-mitotiques (Ezan et al., 2013), mais aussi sur la dynamique d’actine (Mauriac et al., 2017)
Hearing loss is the most common sensory disorder, affecting 40% of people over 65 years old, leading for these patients, to the deterioration of their quality of life and to their social isolation. The main causes are aging or exposure to noise. However, many genes can also cause deafness. Among these deafnesses, the Chudley McCullough Syndrome (CMCS) is a rare disease characterized by severe and early deafness associated with brain abnormalities (Chudley et al., 1997). Recently, mutations in the GPSM2 (G protein signaling modulator 2) gene were found to be causative of this pathology, but the molecular basis were unknown (Walsh et al., 2010). Using a murine model of this pathology, we identified the molecular basis of this pathology as well as a new molecular function for Gpsm2 on the modulation of actin cytoskeleton. The disruption of this function leads to defect of the maturation of auditory hair cells and the reduction of the outgrowth of young neurons which may explain the deafness and the hypoplasia of the corpus callosum described in these patients (Mauriac et al., 2017). In addition, we identified partners of Gpsm2, Gαi proteins, as essential for auditory function (Beer-Hammer et al., 2018). At the molecular level, we have discovered a new interaction of Gpsm2 with a protein essential for the maturation of auditory cells and involved in Usher type deafness, Whirlin.Therefore, our study clarified the etiology of CMCS and show that the complexity and multisyndromic aspect of this pathology is due to the multifunctional role of the complex Gpsm2/G⍺i not only on tubulin dynamics in proliferating cells and post-mitotic cells (Ezan et al., 2013), but also on actin dynamics (Mauriac et al., 2017)
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Killick, Richard. "The molecular cloning of chick and mouse tectorins and cochlear homologues of the amiloride-sensitive epithelial sodium channel." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295959.

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Tan, Lirong. "Identification of Disease Biomarkers from Brain fMRI Data using Machine Learning Techniques: Applications in Sensorineural Hearing Loss and Attention Deficit Hyperactivity Disorder." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689755.

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Abramides, Patricia Arena. "Avaliação sequencial do equilíbrio pré e pós-implante coclear em pacientes com surdez pós-lingual." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-25112014-150742/.

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INTRODUÇÃO: A literatura é discordante com relação à interferência do IC sobre o equilíbrio corporal. Sendo assim, resolvemos avaliar o equilíbrio corporal de pacientes surdos pós-linguais, submetidos a implante coclear unilateral. OBJETIVO: Observar o equilíbrio corporal pré e pós-implante coclear (IC) ao longo de 1 ano. CASUÍSTICA E METODOLOGIA: Estudo prospectivo observacional realizado com 24 pacientes adultos, surdos pós-linguais submetidos à avaliação vestibular antes e depois da cirurgia de implante coclear unilateral. A avaliação vestibular contou com um questionário sobre vertigem, prova calórica (PC), cadeira rotatória (CR) e posturografia dinâmica computadorizada (PDC) aplicados no pré-operatório, 60, 120, 180 dias e 1 ano após a cirurgia de IC. RESULTADOS: A tontura foi referida por 13 (54,2%) pacientes pré-IC, enquanto 11 (45.8%) não apresentaram a queixa. Ao final do estudo 11 sujeitos (84,6%) referiram melhora da tontura, em 1 (7,7%) permaneceu inalterada e em 1 (7,7%) piorou. Dos 24 pacientes apenas 5 indivíduos (20,8%) desenvolveram tontura no pós-operatório imediato com resolução completa após um mês. A prova calórica identificou 7 (29,2%) sujeitos normorreflexos, 8 (33,3%) com hiporreflexia ou arreflexia unilateral , 3 (12,5%) com hiporreflexia bilateral e 6 (25%) com arreflexia vestibular bilateral (AVB).Houve interferência do estímulo elétrico em ambas as orelhas e na evolução da recuperação postural após ativação do IC, que promoveu a melhora significativa dos índices da PDC ao longo de um ano de acompanhamento. Ao final do estudo, as médias numéricas das condições avaliadas pela PDC mostraram-se superiores nos indivíduos que apresentaram resposta à prova calórica em relação àqueles que possuíam AVB. CONCLUSÃO: Foi decisiva a presença ou não de resposta pós-calórica na evolução do equilíbrio corporal ao longo de 1 ano. A ausência de resposta pós-calórica na avaliação pré-operatória implicou em pior prognóstico na evolução do equilíbrio corporal. No entanto, o melhor desempenho postural dos sujeitos com AVB pode ser explicado pelo melhor aproveitamento da informação visual. É fundamental documentar a presença de função vestibular antes da cirurgia de IC, pois dela depende o prognóstico do individuo em relação às habilidades de aprendizado e recuperação postural ao longo do tempo
INTRODUCTION: There is no consensus in the literature with regard to the effects of cochlear implantation (CI) on vestibular function and balance in patients with deafness. Because of this fact we decided to assess vestibular function before and after unilateral cochlear implantation (CI) in patients with postlingual deafness. OBJECTIVE: To assess balance before and after cochlear implantation (CI) over the course of 1 year. PATIENTS AND METHODS: prospective, observational study sought to assess balance in 24 postlingually deaf adults undergoing vestibular evaluation before and after cochlear implantation (CI). Vestibular assessment consisting of a vertigo questionnaire, caloric tests (CT), rotary chair testing (RC), and computerized dynamic posturography (CDP) was performed preoperatively and at 60, 120, 180 days and 1 year after CI. RESULTS: Overall, 13 patients (54.2%) reported preoperative dizziness and 11 (45.8%) did not have the symptom pre-CI. At the end of the study dizziness ameliorated in 11 (84.6%), remained unchanged in 1 (7.7%) and worsened in 1 (7.7%). Only 5 of the 24 patients (20.8%) developed immediate postoperative dizziness, which resolved within a month. The caloric tests identified 7 (29.2%) patients with normal reflexes, 8 (33.3%) with unilateral areflexia or hyporeflexia, 3 (12.5%) with bilateral hyporeflexia, and 6 (25%) with bilateral vestibular loss (BVL). Electrical stimulation affected both ears and interfered with the progression of postural recovery after CI activation, which led to a significant improvement in CDP values over the course of 1 year of follow-up. At the end of the study, the mean values of the conditions assessed by CDP were higher in individuals who had responded to caloric tests than in individuals with BVL. The better postural performance of subjects with BVL may be due to better use of visual information. CONCLUSION: The presence or absence of CT response was a decisive determinant of balance outcomes over the year after surgery. The absence of post-caloric response in preoperative assessment resulted in a worse prognosis in the evolution of body balance. However, patients with BVL were able to use the visual information for postural stabilization with improvement in the Composite Score. It is essential that vestibular assessment findings be documented before CI surgery because a patient\'s prognosis in terms of learning skills and postural recovery over time depends on this information
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Pinsetta, Flávio Roberto. "Síntese e relação estrutura-toxicidade de derivados aminoglicosídeos como potenciais protótipos na busca de um fármaco seguro para o tratamento da Doença de Ménière." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-03052010-182901/.

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Os aminoglicosídeos são antibióticos utilizados para o tratamento de muitas infecções bacterianas graves. A maioria é produzida por microorganismos (gêneros Streptomyces e Actinomyces), mas a semi-síntese resultam na descoberta de notáveis aminoglicosídeos. Apesar de seu mecanismo de ação seletivo, os aminoglicosídeos são extremamente tóxicos. A nefrotoxicidade e ototoxicidade são mais freqüentemente observadas. Sabe-se que a Doença de Ménière pode ser tratada através da destruição seletiva das células vestibulares, preservando-se as células cocleares (tecidos da orelha interna). Antibióticos aminoglicosídeos são usados para esta finalidade, mas podem paralelamente causar danos cocleares (surdez). O estudo de relação estrutura-toxicidade dos resíduos de fragmentação de antibióticos aminoglicosídeos pode originar produtos simplificados, com atividade vestibular seletiva, dissociada da atividade coclear, mais seguros para o tratamento da Doença de Ménière. Em trabalhos anteriores, os ensaios envolvendo 2-desoxi-estreptamina e estreptidina demonstraram que não são tóxicos ao tecido coclear, quando comparados com os compostos originais. Neamina, outro fragmento de neomicina, se mostrou mais tóxica ao vestíbulo que a própria neomicina, mas aprensentou também grande toxicidade coclear. A substituição da unidade diamino-glicosídica de neamina, contendo o grupo 2-desoxi-estreptamina, por outras unidades glicosídicas (glicose, galactose, glicosamina) representa uma tentativa de eliminar a atividade cocleotóxica e manter a atividade vestibulotóxica original (100%). A mesma idéia pode ser também aplicada ao resíduo de estreptidina. Desta forma, foram sintetizados, dois pseudos-dissacarídeos, 2-desoxi-estreptamina ligado a galactose (48) e 2-desoxi-estreptamina ligado a glicose (49), ambas as ligações em posição referente ao carbono glicosídico anomérico. Apenas o pseudo-dissacarídeo 2-desoxi-estreptamina ligado a galactose (48) foi obtido com massa suficiente para analise ototóxica, o qual apresentou atividade vestibular seletiva como desejado, no tratamento da doença de Ménière. Ensaios de atividade antimicrobiana foram realizados empregando ambos pseudos-dissacarídeos sintetizados, 2-desoxi-estreptamina ligada a galactose (48) e 2-desoxi-estreptamina ligada a glicose (49), porém não apresentaram uma concentração inibitória mínima (MIC) significativa para as cepas testadas.
Aminoglycosides are antibiotics used for the treatment of many serious bacterial infections. Most are produced by microorganisms (genera Streptomyces and Actinomyces), but products obtained by semi-synthesis resulted in the discovery of remarkable aminoglycosides. Despite their selective mechanism of action, the aminoglycosides are highly toxic. The nephrotoxicity and ototoxicity are more frequently observed. It is known that Ménière\'s disease can be treated by selective destruction of the vestibular cells, preserving the cells cochlear (inner ear tissues). Aminoglycoside antibiotics are used for this purpose but may cause cochlear damage (deafness). The study of structure-toxicity of residues fragmentation of aminoglycoside antibiotics may lead to simplified products, with selective vestibular activity, dissociated from the cochlear activity, safer for the treatment of Ménière\'s disease. In previous work, the experiments involving 2-deoxy-streptamine and streptidine demonstrated that they are not toxic to the cochlear tissue, when compared with the original compound. Neamina, another fragment of neomycin, was more toxic to the vestibular tissue than neomycin, but also presented great cochlear toxicity. The replacement of the diamino-glycoside unit of neamina containing the 2-deoxy-streptamine by other glycosidic units (glucose, galactose, glucosamine) is an attempt to eliminate the cochlear toxicity and maintain the original vestibular toxicity (100%). The same idea can also be applied to the streptidine residue. Thus, two pseudo-disaccharides, 2-deoxy-streptamine linked to galactose (48) and 2-deoxy-streptamine linked to glucose (49), both linked to the position on the glycoside anomeric carbon. Only the pseudo-disaccharide 2-deoxy-streptamine linked to galactose (48) was obtained in sufficient quantity to perform the ototoxic assay, which presented selective vestibular activity as desired in the treatment of Ménière\'s disease. Antimicrobial activity assays were performed with both pseudo-disaccharides synthesized 2-deoxy-streptamine linked to galactose (48) and 2-deoxy- streptamine linked to glucose (49), but did not show a minimum inhibitory concentration (MIC) significant against the strains tested.
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Goßow-Müller-Hohenstein, Elmen. "Hydropsdiagnostik mit Tieftonmodulation von Distorsionsprodukt-Otoemissionen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15349.

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Ein tieffrequenter lauter Suppressorton verlagert das Corti-Organ periodisch in Richtung Scala vestibuli und Scala tympani. Simultan registrierte DPOAE (Distorsionsprodukte otoakustischer Emissionen) werden in beiden Richtungen unterschiedlich supprimiert. Bei Vorliegen eines endolymphatischen Hydrops (EH) ist die Beweglichkeit der Basilarmembran eingeschränkt, so daß keine oder eine nur geringe Modulation des DPOAE-Pegels entstehen kann. In dieser Arbeit wird die diagnostische Aussagekraft von Messungen tieftonmodulierter DPOAE bei zwei Patientenkollektiven mit Verdacht auf EH im Vergleich mit einem Normalkollektiv (n = 22) geprüft: bei Patienten mit M. Menière (n = 23) und Patienten mit Ohrdruckgefühl ohne Schwindelsymptomatik (n = 8). Bei den M. Menière-Patienten sind die ipsilateralen Modulationstiefen (MD) im Median hochsignifikant geringer als die des Normalkollektivs. Dies wird als Hinweis auf einen EH gewertet. Bei Primärtonpegeln mit L2 = 20 dB SL ergibt sich für den Grenzwert der MD mit 6 dB die Sensitivität von 64% und die Spezifität von 90%. Die kontralateralen MD der M. Menière-Patienten sind im Median signifikant geringer als die des Normalkollektivs. Für Primärtonpegel mit L2 = 20 dB SL liegen 33% der Werte unter dem Grenzwert, von diesen Ohren ist die Hälfte symptomfrei. Auch im kontralateralen Ohr kann ein – eventuell asymptomatischer – Hydrops vorliegen. Die Ergebnisse der Patienten mit Ohrdruckgefühl ohne Schwindel zeigen im Median hochsignifikant geringere MD als die der Normalhörenden und unterscheiden sich nicht signifikant von den Werten der ipsilateralen Ohren der M. Menière-Patienten. Das Ohrdruckgefühl kann auf einen cochleären Hydrops hinweisen und die weitere Entwicklung eines EH ankündigen. Bei den Verlaufsuntersuchungen zeigen die MD beider Patientenkollektive, deren Symptomatik sich während dieses Zeitraums änderte, Variabilitäten: mit Zunahme der Heftigkeit der spezifischen Symptome nimmt die MD ab und umgekehrt. Die Tieftonmodulation scheint den Zustand der Cochlea widerspiegeln zu können. Im Vergleich mit den in der Klinik gängigen Verfahren zur Hydropsdiagnostik wie der ECochG oder dem Glyceroltest erweist sich das in dieser Arbeit angewandte objektive Verfahren als vorteilhaft: es ist schnell durchführbar, nicht belastend und nicht invasiv. Es eignet sich als Screeningverfahren und kann zur Verlaufskontrolle eingesetzt werden.
The cochlear partition is moved periodically towards scala vestibuli and scala tympani by a low-frequency high-level suppressor tone. Simultaneously recorded DPOAEs (distortion product otoacoustic emissions) are suppressed differently in both directions. This modulation of the DPOAE level may be reduced or even missing if the displacement of the basilar membrane is inhibited by endolymphatic hydrops (EH). In this thesis the diagnostic significance of the low-frequency modulation of DPOAEs is tested in two patient groups with suspected EH: patients with Menière’s disease (n = 23) and patients with aural fullness without vertigo (n = 8), compared to a control group of normal hearing adults (n = 22). In the patients with Menière’s disease the ipsilateral modulation depths (median) are high significantly lower than in the control group. This can be interpreted as a sign of EH. At primary tone levels with L2 = 20 dB SL and a limiting value of 6 dB modulation depth (MD), a sensitivity of 64% and a specificity of 90% are found. The contralateral MDs of the patients with Menière’s disease (median) are significantly lower than in the control group. At primary tone levels with L2 = 20 dB SL, 33% of the MDs are below the limiting value, half of these ears are symptom-free. So in the contralateral ear a possibly asymptomatic hydrops may be present as well. The patients with aural fullness without vertigo show high significantly lower MDs (median) than the normal hearing adults and no significant difference to the ipsilateral MDs of the patients with Menière’s disease. Aural fullness can be a sign of cochlear hydrops and may indicate the further development of EH. During the course of disease the MDs of both patient groups vary when symptoms change: with increasing intensity of the specific symptoms the MD is reduced and vice versa. Low-frequency modulation seems to reflect the state of the cochlea. Compared to the generally used clinical tests for the assessment of EH like ECochG or the glycerol test, the objective method presented in this thesis is advantageous: it is fast, not straining and non-invasive. It is suitable for screening and can be used to monitor the course of disease.
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Hsiu-Lien, Cheng, and 鄭秀蓮. "The comparison of cochlear traveling time in Meniere’s disease and normal hearing ears using derived-band cochlear compound action potentials and auditory brainstem responses." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/44926540443587003516.

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碩士
國立台北護理學院
聽語障礙科學研究所
96
Background: This study is designed for comparing the cochlear traveling time difference between ears of Meniere’s disease (MD) patients and normal subjects. Both derived-band auditory brainstem responses (ABRs) and compound action potentials (CAPs) detecting techniques were used. To improve the recognized waveform latencies, the CAP was detected by using the Biologic TM-EcochGtrode system electrodes. Derived-band technique was adopted and modified from previous literature by applying an ipsilateral high-pass masking noise. Material and Methods: This study received institutional review board approval. Twenty-two unilateral Meniere’s disease patients (8 males, 14 females) diagnosed according to the 1995 guidelines published by American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS, 1995) were included with the symptom presented within one week, aged 26 to 60 years, and thirty ears from thirty subjects with hearing sensitivity within normal limits (15 left, 15 right), aged 20 to 43 years. All subjects underwent extratympanic electrode insertion using the Biologic TM-ECochGtrode system (Biologic Systems Corp, Mundelein,Ill) and ABR responses to six stimulus conditions were obtained, including click alone and click presented with various ipsilateral pink noise high-pass filtered maskers (cut-off frequencies were close to 8000, 4000, 2000, 1000 and 500 Hz). Six auditory brainstem evoked potentials are recorded and subtracted by each other, resulting in above 8000 Hz, 8000-4000 Hz, 4000-2000 Hz, 2000-1000 Hz and 1000-500 Hz five derived-band ABRs. Estimates from derived-band ABRs and CAP were comparable to each other. Results: More than 85 % for both derived-band CAP and wave V latencies can be identified in a low-frequency band (500-1000 Hz). The percentage of recognizable latency presented in derived-band CAP (93.4 %) is higher than the one in ABR wave V (89.0 %) across all frequencies. Both peak latencies presented in derived-band CAP and ABR wave V increase as the cochlea is masked from 8 kHz and higher down to 0.5 kHz. The absolute band-derived latency distribution presented in MD group overlaps the one in normal hearing group either observed in CAP or wave V. The latency difference between click alone and band-derived ABR detected both in CAP and wave V, also revealed no significant difference compared between experimental and normal groups. However, the latency change between click alone and band-derived ABR evaluated in both CAP and wave V, significant increase in MD group when compared with normal hearing group at low frequency band (500-1000 Hz) (P< 0.05). Conclusion: 1. Recognizable latencies presented in derived-band CAP are improved by tympanic membrane electrodes recording. 2. With this modified derived-band CAP recording, the identification ratio of cochlear traveling wave velocity in CAP is higher than the one in ABR wave V. 3. By comparing the absolute peak latency values at each band-derived frequency between MD group and control group, there is no significant difference. This result may be referred to the variation of disease progression in collected MD patients in this study. 4. Both band-derived CAP and ABR wave V can detect the alteration of the cochlear traveling wave velocity in a low frequency band of 500-1000 Hz when compared using latency change in MD group. This result suggests that the derived-band technique may be more sensitive in detecting an endolymphatic hydrop condition in an assumed low frequency map in the cochlea.
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Koehler, Karl R. "Reconstitution of mouse inner ear sensory development from pluripotent stem cells." Thesis, 2014. http://hdl.handle.net/1805/6238.

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Indiana University-Purdue University Indianapolis (IUPUI)
The inner ear contains specialized sensory epithelia that detect head movements, gravity and sound. Hearing loss and imbalance are primarily caused by degeneration of the mechanosensitive hair cells in sensory epithelia or the sensory neurons that connect the inner ear to the brain. The controlled derivation of inner ear sensory epithelia and neurons from pluripotent stem cells will be essential for generating in vitro models of inner ear disorders or developing cell-based therapies. Despite some recent success in deriving hair cells from mouse embryonic stem (ES) cells, it is currently unclear how to derive inner ear sensory cells in a fully defined and reproducible manner. Progress has likely been hindered by what is known about induction of the nonneural and preplacodal ectoderm, two critical precursors during inner ear development. The studies presented here report the step-wise differentiation of inner ear sensory epithelia from mouse ES cells in three-dimensional culture. We show that nonneural, preplacodal and pre-otic epithelia can be generated from ES cell aggregates by precise temporal control of BMP, TGFβ and FGF signaling, mimicking in vivo development. Later, in a self-guided process, vesicles containing supporting cells emerge from the presumptive otic epithelium and give rise to hair cells with stereocilia bundles and kinocilium. Remarkably, the vesicles developed into large cysts with sensory epithelia reminiscent of vestibular sense organs (i.e. the utricle, saccule and crista), which sense head movements and gravity in the animal. We have designated these stem cell-derived structures inner ear organoids. In addition, we discovered that sensory-like neurons develop alongside the organoids and form putative synapses with hair cells in a similar fashion to the hair cell-to-neuron circuit that forms in the developing embryo. Our data thus establish a novel in vitro model of inner ear organogenesis that can be used to gain deeper insight into inner ear development and disorder.
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Books on the topic "Cochlea – Diseases"

1

International Cochlea-Symposion. (8th 1987 Halle an der Saale, Germany). VIII International Cochlea-Symposion: Halle (Saale), May 28.-31., 1987. Edited by Loebe Lutz-Peter and Lotz Peter. Halle (Saale): Martin-Luther-Universität Halle-Wittenberg, 1988.

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2

A, Uziel, and Mondain M, eds. Cochlear implants in children: European Symposium on Paediatric Cochlear Implantation, Montpellier/La Grande Motte, May 26-28, 1994. Basel: Karger, 1995.

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Serbetcioglu, Mustafa Bulent. Estimation and comparison of cochlear travelling wave measures in subjects withnormal hearing and patients with Mínières disease. Manchester: University of Manchester, 1995.

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1945-, Ryan Allen F., ed. Gene therapy of cochlear deafness: Present concepts and future aspects. Basel: Karger, 2009.

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International Symposium on Ophthalmo-Neuro-Otology (1985 Budapest, Hungary). Proceedings of the International Symposium on Ophthalmo-Neuro-Otology, Budapest, Hungary, October 4-5, 1985. [Budapest] Published by the Ophthalmo-Otological Section of the Hungarian Oto-Rhino-Laryngological Society, 1985.

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European Symposium on Paediatric Cochlear Implantation 1994 montpelli and A. S. Uziel. Cochlear Implants in Children: 2nd European Symposium on Pediatric Cochlear Implantation, Montpellier/LA Grande Motte, May 26-28, 1994 (Advances in Oto-Rhino-Laryngology). S. Karger Publishers (USA), 1995.

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Goodyer, Paul. Kidney/ear syndromes. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0170.

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Malformations of the external ear may signal renal disease, but it is actually the disorders of the inner ear which reflect molecular pathways that are also crucial for kidney development. In a number of monogenic renal diseases, renal dysplasia is associated with deafness. Disorders of the kidney and inner ear are also linked in complex syndromes such as the human ciliopathies. In some cases, the loss of specific genes affects shared transport physiology, basement membrane assembly, or energy metabolism.The kidney and cochlea have a common susceptibility to toxins that are selectively concentrated by comparable uptake mechanisms in the two tissues.This chapter provides an overview of the many ways in which pathologies of the two organs are linked.
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Scott, Gazelle G., and Saini Sanjay, eds. Hepatobiliary and pancreatic radiology: Imaging and intervention. New York: Thieme, 1998.

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S, Robinette Martin, and Glattke Theodore J, eds. Otoacoustic emissions: Clinical applications. New York: Thieme, 1997.

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(Editor), G. Scott Gazelle, Sanjay Saini (Editor), and Peter R. Mueller (Editor), eds. Hepatobiliary and Pancreatic Radiology: Imaging and Intervention. Thieme Medical Publishers, 1997.

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Book chapters on the topic "Cochlea – Diseases"

1

Yamaguchi, T., T. Himi, Y. Harabuchi, M. Hamamoto, and A. Kataura. "Cochlear Implantation in a Patient with Mitochondrial Disease-Kearns-Sayre Syndrome: A Case Report." In Cochlear Implant and Related Sciences Update, 321–23. Basel: KARGER, 1997. http://dx.doi.org/10.1159/000059031.

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Damen, G. W. J. A., E. A. M. Mylanus, and A. F. M. Snik. "Cochlear Implantation and Quality of Life in Deafness." In Handbook of Disease Burdens and Quality of Life Measures, 3887–904. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_226.

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Saeed, S. R., and D. J. Mawman. "Cochlear Implant Outcomes and Quality of Life in the Elderly." In Handbook of Disease Burdens and Quality of Life Measures, 2667–73. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_155.

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Shinjo, Yukiko, Yulian Jin, and Kimitaka Kaga. "Cochlear Implantation for a Child with Auditory Nerve Disease: a Case Report." In Neuropathies of the Auditory and Vestibular Eighth Cranial Nerves, 77–82. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-09433-3_9.

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Low, W. K., R. Burgess, and C. K. Teoh. "Cochlear Implantation in a Patient with Cogan�s Syndrome, Chronic Ear Disease and on Steroid Therapy." In Advances in Oto-Rhino-Laryngology, 157–59. Basel: KARGER, 2000. http://dx.doi.org/10.1159/000059226.

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Kaga, Kimitaka, and Yusuke Akamatsu. "Environmental Sound Perception in Patients with Cochlear Implants Compared with That in Patients with Auditory Nerve Diseases (Auditory Neuropathy) and Cortical Deafness." In Neuropathies of the Auditory and Vestibular Eighth Cranial Nerves, 53–59. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-09433-3_6.

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"Cochlea." In Handbook of Disease Burdens and Quality of Life Measures, 4170–71. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_5329.

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"Cochlear Implant." In Handbook of Disease Burdens and Quality of Life Measures, 4171. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-0-387-78665-0_5330.

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Bansal, Mohan. "Hearing Aids and Cochlear Implants." In Diseases of Ear, Nose and Throat, 173. Jaypee Brothers Medical Publishers (P) Ltd., 2013. http://dx.doi.org/10.5005/jp/books/11788_15.

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Näätänen, Risto, Teija Kujala, and Gregory Light. "Neurological disorders." In The Mismatch Negativity, 113–52. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198705079.003.0006.

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The MMN amplitude is decreased and/or peak latency prolonged in a large number of different neurological disorders, such as neurodegenerative diseases, brain lesions, cochlear lesions, chronic pain, or tinnitus. This is to a great extent due to a decreased brain plasticity affecting the formation of memory traces for different sensory stimuli essential for different cognitive operations of the brain. Furthermore, MMN can serve as a measure of recovery or neural reorganization in different neurological disorders. For example, the recovery from aphasic symptoms after stroke was associated with the enhancement of MMN. MMN has also been useful in determining neural plastic changes of the auditory system associated with cochlear implantation.
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Conference papers on the topic "Cochlea – Diseases"

1

Willenborg, K., A. Giesemann, and T. Lenarz. "Hydrops-MRT: Correlation of cochlear and vestibular hydrops with clinical symptoms in Ménière's disease." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640691.

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Gyoneva, Lazarina, Mohammad F. Hadi, Yoav Segal, Kevin D. Dorfman, and Victor H. Barocas. "Role of Lateral Interactions in Type IV Collagen Network Mechanics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14625.

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The basement membrane is a specialized part of the extra-cellular matrix. It is usually characterized as a scaffold for epithelial cells but in some tissues it serves other, mechanical, roles [1]. The mechanical properties of the basement membrane are mainly determined by one of its main constituents — type IV collagen. Unlike the well-known fibrous type I collagen, collagen IV assembles into planar networks (Fig. 1) [2]. The α 1(IV) and α 2(IV) collagen IV chains assemble into the so-called major chain network, present in all basement membranes. The α 3(IV), α 4(IV), α 5(IV) collagen IV chains form the minor chain network which is found only in the adult basement membranes of the kidney glomerular capillaries (GBM), ocular lens (LBM), cochlea, and the testes [3]. The minor chains have a higher number of cysteine residues, allowing them to form a higher number of lateral interactions. In the minor chain network, the greater potential to interact laterally manifests in the formation of super-coils, which are rarely observed in the major chain network [4]. Increasing the number of cross-links in a polymeric material is known to increase material stiffness; therefore, it is believed that the minor chain network confers basement membranes with additional strength and stability [5]. In the hereditary disease Alport syndrome, a mutation causes the absence of the minor chain network. The GBM and LBM of Alport patients appear weakened and unable to meet their mechanical demands, further supporting this theory [6]. The objective of this study was to evaluate the importance of cross-linking in the minor chains for the mechanical properties of type IV collagen networks, specifically in the GBM and LBM where the absence of the minor chains has an observed mechanical effect.
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Doobe, G., A. Ernst, I. Todt, and P. Mittmann. "Lateral Semicircular Canal Occlusion, Saccus Decompression And Cochlear Implantation: A New Approach For Refractory Menière's Disease And Functional Deafness." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640294.

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Lauer, G., P. Mittmann, J. Wagner, R. Seidl, and A. Ernst. "Longterm Follow-up in patients with simultaneous labyrinthectomy and cochlear implantation unilateral Menière's disease and profound sensorineural hearing loss." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686435.

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Kamal, B., I. Todt, and H. Sudhoff. "Lateral semicircular canal occlusion, endodolymphatic sac surgery and cochlear implantation: A low destructive treatment option for single sided Meniere's Disease and Deafness." In 100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN? Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1728455.

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