Relevant bibliographies by topics / Cochlea development

Academic literature on the topic 'Cochlea development'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Cochlea development"

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Chen, Penghui, Yongchuan Chai, Haijin Liu, Gen Li, Longhao Wang, Tao Yang, and Hao Wu. "Postnatal Development of Microglia-Like Cells in Mouse Cochlea." Neural Plasticity 2018 (July 31, 2018): 1–5. http://dx.doi.org/10.1155/2018/1970150.

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Microglial cells are involved in surveillance and cleaning of the central nervous system. Recently, microglial-like cells (MLC) have been found in an adult cochlea and investigated for their role in cochlear inflammation. The presence and potential roles of MLCs during the development of the cochlea, however, remain unclear. In this study, immunostaining was performed using the MLC-specific marker IBA1 to characterize the presence, distribution, and morphology of MLCs in the developing cochlea. From P0 to P14, MLCs were present in a variety of cochlear regions including the modiolus, spiral lamina, spiral ganglion, spiral ligament, and the organ of Corti. Interestingly, the overall number of MLCs in a mouse cochlea steadily increased since P0, peaks at P5, then gradually decreased from P5 to P14. In the spiral ligament, the distribution of the MLCs trends to shift from the type I/II fibrocyte-rich regions to the type III/IV fibrocyte-rich regions during the course of cochlear development, accompanied by the morphological changes of MLCs from the amoeboid, activated form to the ramified, quiescent form. Our results suggested that MLCs experience drastic morphological and distributional changes during postnatal cochlear development, which may play a role in the maturing and remodeling of the cochlea.
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Yu, J.-F., K.-C. Lee, Y.-L. Wan, and Y.-C. Peng. "Curvature measurement of human bilateral cochleae." Journal of Laryngology & Otology 129, no. 11 (September 21, 2015): 1085–90. http://dx.doi.org/10.1017/s0022215115002480.

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AbstractObjective:This study aimed to characterise the geometry of the human bilateral spiral cochlea by measuring curvature and length.Method:Eight subjects were recruited in this study. Magnetic resonance imaging was used to visualise the right and left cochlea. Visualisation of the cochlear spiral was enhanced by T2 weighting and further processing of the raw images. The spirals were divided into three segments: the basal turn, the middle turn and the apex turn. The length and curvature of each segment were non-invasively measured.Results:The mean left and right cochlear lengths were 3.11 cm and 3.95 cm, respectively. The measured lengths of the cochlear spiral are consistent with data in the literature derived from anatomical dissections. Overall, the apex turn segment of the cochlea had the greatest degree of curvature (p < 0.05). The mean apex turn segment curvatures for left and right cochleae were 9.65 cm−1 and 10.09 cm−1, respectively.Conclusion:A detailed description of the cochlear spiral is provided, using measurements of curvature and length. These data will provide a valuable reference in the development of cochlear implantation procedures for minimising the potential damage during implantation.
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Hang, Jianfeng, Wenlu Pan, Aoshuang Chang, Shun Li, Cuixian Li, Mingyu Fu, and Jie Tang. "Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats." Neural Plasticity 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/4545826.

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Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear. The electromotility of OHCs driven by prestin is responsible for the cochlear amplification which is required for normal hearing in adult animals. Postnatal expression of prestin and activity of OHCs may contribute to the maturation of hearing in rodents. However, the temporal and spatial expression of prestin in cochlea during the development is not well characterized. In the present study, we examined the expression and function of prestin from the OHCs in apical, middle, and basal turns of the cochleae of postnatal rats. Prestin first appeared at postnatal day 6 (P6) for basal turn, P7 in middle turn, and P9 for apical turn of cochlea. The expression level increased progressively over the next few days and by P14 reached the mature level for all three segments. By comparison with the time course of the development of auditory brainstem response for different frequencies, our data reveal that prestin expression synchronized with the hearing development. The present study suggests that the onset time of hearing may require the expression of prestin and is determined by the mature function of OHCs.
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Keppeler, Daniel, Christoph A. Kampshoff, Anupriya Thirumalai, Carlos J. Duque-Afonso, Jannis J. Schaeper, Tabea Quilitz, Mareike Töpperwien, et al. "Multiscale photonic imaging of the native and implanted cochlea." Proceedings of the National Academy of Sciences 118, no. 18 (April 26, 2021): e2014472118. http://dx.doi.org/10.1073/pnas.2014472118.

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The cochlea of our auditory system is an intricate structure deeply embedded in the temporal bone. Compared with other sensory organs such as the eye, the cochlea has remained poorly accessible for investigation, for example, by imaging. This limitation also concerns the further development of technology for restoring hearing in the case of cochlear dysfunction, which requires quantitative information on spatial dimensions and the sensorineural status of the cochlea. Here, we employed X-ray phase-contrast tomography and light-sheet fluorescence microscopy and their combination for multiscale and multimodal imaging of cochlear morphology in species that serve as established animal models for auditory research. We provide a systematic reference for morphological parameters relevant for cochlear implant development for rodent and nonhuman primate models. We simulate the spread of light from the emitters of the optical implants within the reconstructed nonhuman primate cochlea, which indicates a spatially narrow optogenetic excitation of spiral ganglion neurons.
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Swain, Santosh Kumar. "Cochlear deformities and its implication in cochlear implantation: a review." International Journal of Research in Medical Sciences 10, no. 10 (September 27, 2022): 2339. http://dx.doi.org/10.18203/2320-6012.ijrms20222547.

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Hearing loss is one of the world’s leading causes of chronic health conditions. Cochlea plays a vital role in the hearing mechanisms and it converts sound energy into electrical stimuli which are transmitted to the brain through the neural pathway. The human cochlea is difficult to explore because of its vulnerability and bordering bony capsule. Congenital malformation of the inner ear or cochlea is an important cause of congenital sensorineural hearing loss. The deformity of the cochlea may result from arrested development of cochlea at different stages of fetal life or from abnormal development due to genetic abnormalities. There are hair cells responsible for converting sound energy into electrical impulses. These hair cells are easily damaged, which results in permanent hearing loss. Cochlear implants are surgically implantable biomedical devices that bypass the sensory hair cells and directly stimulate the remaining fibers of the auditory nerve with an electric current. Cochlear implantation is capable of restoring a surprisingly large degree of auditory perception to patient that is suffering from severe to profoundly deaf. Children with cochlear anomalies are thought to have poorer outcomes with cochlear implantations, therefore would be poorer candidates due to their diminished ability to interpolate and use auditory information provided through a cochlear implant. Parents should be counselled to establish realistic post-implant expectations in case of children with cochlear deformity. So, patient selection has emerged as one of the most vital determinants of successful outcomes after pediatric cochlear implantation.
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Szczepek, Agnieszka J., Tatyana Dudnik, Betül Karayay, Valentina Sergeeva, Heidi Olze, and Alina Smorodchenko. "Mast Cells in the Auditory Periphery of Rodents." Brain Sciences 10, no. 10 (October 1, 2020): 697. http://dx.doi.org/10.3390/brainsci10100697.

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Mast cells (MCs) are densely granulated cells of myeloid origin and are a part of immune and neuroimmune systems. MCs have been detected in the endolymphatic sac of the inner ear and are suggested to regulate allergic hydrops. However, their existence in the cochlea has never been documented. In this work, we show that MCs are present in the cochleae of C57BL/6 mice and Wistar rats, where they localize in the modiolus, spiral ligament, and stria vascularis. The identity of MCs was confirmed in cochlear cryosections and flat preparations using avidin and antibodies against c-Kit/CD117, chymase, tryptase, and FcεRIα. The number of MCs decreased significantly during postnatal development, resulting in only a few MCs present in the flat preparation of the cochlea of a rat. In addition, exposure to 40 µM cisplatin for 24 h led to a significant reduction in cochlear MCs. The presence of MCs in the cochlea may shed new light on postnatal maturation of the auditory periphery and possible involvement in the ototoxicity of cisplatin. Presented data extend the current knowledge about the physiology and pathology of the auditory periphery. Future functional studies should expand and translate this new basic knowledge to clinics.
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Köles, László, Judit Szepesy, Eszter Berekméri, and Tibor Zelles. "Purinergic Signaling and Cochlear Injury-Targeting the Immune System?" International Journal of Molecular Sciences 20, no. 12 (June 18, 2019): 2979. http://dx.doi.org/10.3390/ijms20122979.

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Hearing impairment is the most common sensory deficit, affecting more than 400 million people worldwide. Sensorineural hearing losses currently lack any specific or efficient pharmacotherapy largely due to the insufficient knowledge of the pathomechanism. Purinergic signaling plays a substantial role in cochlear (patho)physiology. P2 (ionotropic P2X and the metabotropic P2Y) as well as adenosine receptors expressed on cochlear sensory and non-sensory cells are involved mostly in protective mechanisms of the cochlea. They are implicated in the sensitivity adjustment of the receptor cells by a K+ shunt and can attenuate the cochlear amplification by modifying cochlear micromechanics. Cochlear blood flow is also regulated by purines. Here, we propose to comprehend this field with the purine-immune interactions in the cochlea. The role of harmful immune mechanisms in sensorineural hearing losses has been emerging in the horizon of cochlear pathologies. In addition to decreasing hearing sensitivity and increasing cochlear blood supply, influencing the immune system can be the additional avenue for pharmacological targeting of purinergic signaling in the cochlea. Elucidating this complexity of purinergic effects on cochlear functions is necessary and it can result in development of new therapeutic approaches in hearing disabilities, especially in the noise-induced ones.
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Henley, Charles M. "Kanamycin Depletes Cochlear Polyamines in the Developing Rat." Otolaryngology–Head and Neck Surgery 110, no. 1 (January 1994): 103–9. http://dx.doi.org/10.1177/019459989411000112.

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Developing mammals are more sensitive to aminoglycoside antibiotics and other ototoxic agents than adults, with maximum sensitivity occurring during the period of anatomic and functional maturation of the cochlea. For the aminoglycoside antibiotics, the hypersensitive period in rats occurs during the second and third postnatal weeks. Toxicity is initially expressed as outer hair cell (OHC) damage in the high-frequency, basal region of the cochlea. Distortion-product otoacoustic emissions (DPOAEs), physiologic measures of OHC function, are particularly sensitive to aminoglycoside exposure during the period of rapid cochlear physiologic development. Toxicity is characterized by increased DPOAE thresholds and decreased amplitudes. The mechanism of developmental sensitivity to aminoglycosides is unknown. A potential biochemical target of aminoglycosides is the ornithine decarboxylase (ODC)-polyamine pathway. ODC activity is elevated in the developing rat cochlea, aminoglycosides inhibit cochlear ODC in developing rats, and α-difluoromethylornithine (a specific ODC inhibitor) impairs development of cochlear function. In the present study we demonstrate an incomplete polyamnine response to aminoglycoside damage, characterized by inhibition of the polyamines spermidine and spermine and accumulation of putrescine in the organ of Corti. Aminoglycoside inhibition of polyamine synthesis may mediate developmental ototoxic hypersensitivity by interfering with developmental and repair processes.
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Kössl, M., E. Foeller, M. Drexl, M. Vater, E. Mora, F. Coro, and I. J. Russell. "Postnatal Development of Cochlear Function in the Mustached Bat, Pteronotus parnellii." Journal of Neurophysiology 90, no. 4 (October 2003): 2261–73. http://dx.doi.org/10.1152/jn.00100.2003.

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Postnatal development of the mustached bat's cochlea was studied by measuring cochlear microphonic and compound action potentials. In adults, a cochlear resonance is involved in enhanced tuning to the second harmonic constant frequency component (CF2) of their echolocation calls at ∼61 kHz This resonance is present immediately after birth in bats that do not yet echolocate. Its frequency is lower (46 kHz) and the corresponding threshold minimum of cochlear microphonic potentials is broader than in adults. Long-lasting ringing of the cochlear microphonic potential after tone stimulus offset that characterizes the adult auditory response close to CF2 is absent in newborns. In the course of the first 5 postnatal weeks, there is a concomitant upward shift of CF2 and the frequency of cochlear threshold minima. Up to the end of the third postnatal week, sensitivity of auditory threshold minima and the Q value of the cochlear resonance increase at a fast rate. Between 2 and 4 wk of age, two cochlear microphonic threshold minima are found consistently in the CF2 range that differ in their level-dependent dynamic growth behavior and are 1.5–5.7 kHz apart from each other. In older animals, there is a single minimum that approaches adult tuning in its sharpness. The data provide evidence to show that during maturation of the cochlea, the frequency and the sensitivity of the threshold minimum associated with CF2 increases and that these increases are associated with the fusion of two resonances that are partly dissociated in developing animals.
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Vlajkovic, Srdjan M., and Peter R. Thorne. "Purinergic Signalling in the Cochlea." International Journal of Molecular Sciences 23, no. 23 (November 28, 2022): 14874. http://dx.doi.org/10.3390/ijms232314874.

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The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues. Two families of P2 receptors, ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors, activate intracellular signalling pathways that regulate cochlear development, homeostasis, sensory transduction, auditory neurotransmission and response to stress. Of particular interest is a purinergic hearing adaptation, which reflects the critical role of the P2X2 receptor in adaptive cochlear response to elevated sound levels. Other P2 receptors are involved in the maturation of neural processes and frequency selectivity refinement in the developing cochlea. Extracellular ATP signalling is regulated by a family of surface-located enzymes collectively known as “ectonucleotidases” that hydrolyse ATP to adenosine. Adenosine is a constitutive cell metabolite with an established role in tissue protection and regeneration. The differential activation of A1 and A2A adenosine receptors defines the cochlear response to injury caused by oxidative stress, inflammation, and activation of apoptotic pathways. A1 receptor agonism, A2A receptor antagonism, and increasing adenosine levels in cochlear fluids all represent promising therapeutic tools for cochlear rescue from injury and prevention of hearing loss.
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Dissertations / Theses on the topic "Cochlea development"

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Newbold, Carrie. "Electrode tissue interface : development and findings of an in vitro model /." Connect to thesis, 2006. http://repository.unimelb.edu.au/10187/1692.

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In the period immediately following the implantation of a cochlear implant electrode array within the cochlear environment, the power required to stimulate the auditory nerve at preset current levels increases. This rise is due to increases in electrode impedance which in turn is suggested to be a result of tissue growth around the electrode array. The foreign body response initiated by the immune system encapsulates the array in a matrix of fibrous tissue, separating the electrode array from the rest of the body. A second change in electrode impedance occurs with the onset of electrical stimulation. A transitory reduction in impedance has been recorded in animals and humans after stimulation of electrodes. Impedance returns to pre-stimulation levels following the cessation of stimulation. It was suggested that these changes in impedance with stimulation were also related to the tissue growth around the electrode array. A more thorough understanding of the interface was required to ascertain these concepts.
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Erichsen, Susan. "Corticosteroid receptors and Na,K-ATPase in the developing mouse cochlea /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4526-8/.

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Goodyear, Richard John. "Distribution and development of hair-cell surface and extracellular matrix components in the chick inner ear." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359083.

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Wannaprasert, Thanakul. "Comparative anatomy of the mammalian bony cochlea and its ontogenetic development in humans." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/14173/.

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The cochlea is the organ for sound reception. Mammals place varied functional demands on their sense of hearing to meet the requirements of a broad range of ecological niches and diverse behaviours. However, documenting potentially related adaptations of the cochlea to eco-behavioural traits is difficult due to its complex geometry. The present study aims to determine whether the bony cochlea carries eco-behavioural traits that can be used to contextualize our understanding of the fossil record and evolutionary transitions. This study also includes work on ontogenetic changes since these can yield important insights into evolutionary processes resulting in differences of the adult phenotypes. Advanced techniques in micro-CT imaging, 3D image visualization, geometric morphometrics and statistical methods were used to study morphological variations of the bony cochlea across 45 adult eutherian species. Also, the same set of techniques was used to study 12 human fetal (approximately four to nine months of gestation) cochleae in comparison with five adult cochleae. Results revealed that there was a considerable range of variation in form of the mammalian bony cochlea. Potential links between the bony cochlear morphology and hearing, ecology and behaviour were found. Dimensions of the bony cochlea may be indicative of the eco-behavioural niche that a mammal occupies; e.g., fewer than two spiral turns is associated with obligate marine species. Rodents also showed remarkable variation in the cochlear morphology, more so than any other group of mammals studied, reflecting their diverse eco-behavioural traits. Results from the human developmental study showed that whilst the general coiled shape was achieved at the midgestational age, there was size related morphological change during the postnatal period. The round window size reached mature state prior to birth, by approximately the second trimester, whereas the oval window continued to change in size after birth. The postnatal enlargement may be determined by functional requirements of air-borne hearing, particularly with respect to frequency range and sensitivity.
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Rau, Angela. "The mouse tectorins : molecular cloning and mRNA expression during inner ear development." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341072.

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Kishimoto, Ippei. "Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis." Kyoto University, 2020. http://hdl.handle.net/2433/253160.

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Duncan, Jeremy Shane. "Cochlear neurosensory specification and competence: you gata have Gata." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2864.

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Early prosensory specification to develop competence in the otic epithelium is disrupted by mutations of Eya1, Pax2, Sox2, Jag1, and Gata3. Mutations in these genes apparently disrupt sensory competence and may affect Atoh1 upregulation, a gene known to be necessary for sensory cell differentiation within the ear. How these genes interact with each other and other factors within the genetic network of the ear to refine and restrict sensory specification and impart competence to the developing organ of Corti is not known. These genes also interact with other factors expressed adjacent to or within the developing organ of Corti and provide the context to allow prosensory cells, after cell cycle exit, to appropriately respond to Atoh1 expression and differentiate as hair cells. Gata3 is expressed throughout the early placode. As ear development continues Gata3 is restricted to all prosensory areas except that of the saccule. In addition, it is expressed in a subset of delaminating neuroblasts. Gata3 continues to be highly expressed in the cochlear sensory epithelia as cells differentiate, and is expressed in all cells of the organ of Corti through adult. The human disorder caused by haploinsufficiency of Gata3 is known as Hypoparathyriodism, Deafness, and Renal dysplasia syndrome, and has been linked in mice to early hair cell death. I investigated the role of Gata3 in cochlear neurosensory specification utilizing a mouse Gata3 knockout model and a conditionally deleted Gata3 line combined with two cre driver lines (Foxg1cre and Pax2cre). Although both cre lines are expressed in the inner ear with only a slight difference in onset of expression there are major phenotypic differences. While the Foxg1cre:Gata3f/f deletion resulted in an ear closely matching that of the null mutant with a cochlear duct devoid of neurosensory cells, the Pax2cre:Gata3f/f cochlear duct contained patches of partially differentiated hair cells. Through the use of qRT-PCR and in situ hybridization of both mutants I was able to paint a picture of how Gata3 interacts with other prosensory genes to upregulate downstream genes. In particular, Atoh1, was downregulated but not absent with the loss of Gata3. Indicating that Gata3 is one of a set of factors necessary for the proper upregulation of Atoh1 in the cochlea.
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Duque, Afonso Carlos Javier [Verfasser]. "Development and Application of Tools for the Characterization of the Optogenetics Stimulation of the Cochlea / Carlos Javier Duque Afonso." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1217062645/34.

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Harvey, David. "Structural and functional development of the cochlea in normal (CBA/Ca) and hearing impaired shaker-1 (sh-1/sh-1) mice." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329832.

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Markessis, Emily. "Development of an objective procedure allowing frequency selectivity measurements using the masking function of auditory steady state evoked potentials." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209990.

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Introduction

Les surdités cochléaires induisent, outre une audibilité réduite, une série de distorsions de la représentation neurale des sons. Deux des mécanismes à la base de ces distorsions sont d’une part une atteinte de la sélectivité fréquentielle et d’autre part des zones neuro-épithéliales non fonctionnelles. Tant le premier que le second mécanisme apparaissent dans une proportion variable et non prédictible d’un sujet à un autre. Deux tests permettent le diagnostic de ces atteintes spécifiques: la Courbe d’Accord (Tuning Curve: TC) et le Threshold Equalising Noise (TEN) test. La TC, mesurée par une technique psychoacoustique chez un adulte collaborant (Psychophysical TC: PTC), consiste en la mesure du niveau de bruit (masqueur) nécessaire pour masquer un son pur (signal) de fréquence et d’intensité fixes. Le TEN test consiste en la mesure des seuils auditifs dans le silence et en présence d’un bruit égalisateur de seuil (TEN). Ces tests qui requièrent des capacités cognitives adultes normales, ne sont pas applicables aux populations pédiatriques prélinguales.

Ce travail de thèse avait pour but le développement d’un équivalent objectif et non invasif des TCs et du TEN test applicable aux populations pédiatriques. La méthode objective choisie fut les potentiels auditifs stationnaires ou ASSEPs (Auditory Steady State Evoked Potentials). Les ASSEPs sont une réponse électrophysiologique cérébrale évoquée par un stimulus acoustique de longue durée modulé en amplitude et/ou en fréquence.

Méthodes & Résultats

Etape 1

Les développements méthodologiques ont été réalisés sur l’espèce canine et humaine adulte. Les ASSEPs n’ayant jamais été préalablement enregistrés chez le chien, une première étape à consister à définir chez cette espèce les paramètres d’enregistrement optimaux (modulation en amplitude optimale) dont on sait qu’ils interagissent avec l’état veille-sommeil, avec la fréquence testée et probablement avec l’espèce animale investiguée.

A cette fin, les seuils auditifs obtenus chez 32 chiens à l’aide des ASSEPs ont été validés à cinq fréquences audiométriques par comparaison aux seuils obtenus avec les potentiels auditifs du tronc cérébral évoqués aux bouffées tonales.

Les seuils obtenus aux ASSEPs avec les paramètres optimaux d’enregistrement (légèrement différents des paramètres optimaux humains) étaient similaires à ceux obtenus aux bouffées tonales.

Ces résultats ont été publiés dans Clinical Neurophysiology (Markessis et al. 2006; 117: 1760-1771).

Etape 2

La possibilité de mesurer des TCs à l’aide des ASSEPs (ASSEP-TCs) a été évaluée sur 10 chiens. Les données canines ont été comparées à des données de la littérature, çàd aux TC enregistrées chez d’autres espèces et avec d’autres méthodes. Des ASSEP-TCs ont également été enregistrées chez 7 humains adultes et confrontées aux PTCs obtenues chez les mêmes sujets. Les PTCs sont typiquement energistrées avec un signal sinusoïdal alors que le stimulus utilisé pour évoquer un ASSEP est une sinusoïde modulée en amplitude. L’effet des sinusoïdes modulées en amplitude sur les paramètres qualitatifs et quantitatifs des TCs a donc été évalué en comparant les PTCs obtenues avec un son pur et avec un son pur modulé en amplitude chez 10 humains adultes.

Les résultats ont révélé que les ASSEP-TCs enregistrées chez le chien et l’humain présentaient des paramètres qualitatifs et quantitatifs similaires respectivement à ceux décrits dans la littérature et aux PTCs. Par ailleurs, auncun effet des stimuli modulés en amplitude sur les paramètres des PTCs n’a été démontré.

Ces données ont été publiées dans Ear & Hearing (Markessis et al. 2009, 30: 43-53).

Etape 3

Les ASSEP-TCs ont été validées chez 10 chiens en comparant les données aux TC enregistrées par électrocochléographie (Compound Action Potential TC: CAP-TC). Le masqueur utilisé pour les CAP-TCs est typiquement une sinusoïde alors que le masqueur utilisé pour les ASSEP-TCs est un bruit à bande étroite. Dès lors, une comparaison du type de masqueur (sinusoïde vs bruit à bande étroite) sur les paramètres des CAP-TCs et ASSEP-TCs a été réalisée chez 10 chiens.

Les ASSEP-TCs chez le chien se sont révélées qualitativement et quantitativement similaires aux CAP-TCs quel que soit le type de masqueur. Elles presentaient par ailleurs l’avantage d’être moins variables, plus précises et non invasives par rapport aux CAP-TCs.

Ces données ont été publiées dans International Journal of Audiology (Markessis et al. 2010, 49 ;455-62).

Etape 4

Afin d’étudier la validité de la procédure à mettre en évidence des changements de sélectivité fréquentielle dus à une atteinte cochléaire, des ASSEP-TCs ont été obtenues chez 10 chiens cochléo-lésés suite à un trauma acoustique. Les Produits de Distorsion Acoustiques, les potentiels évoqués auditifs du tronc cérébral évoqués par un clic et les ASSEPs à cinq fréquences audiométriques ont été enregisrés afin de délimiter l’étendue de la lésion.

Les ASSEP-TCs ont été fortement altérées, mais pas comme attendu ni suggéré par les mesures fonctionnelles indiquant que le trauma acoustique a créé une lésion différente de celle espérée.

Cette étude doit être poursuivie, des lésions moins importantes créées et une validation histopathologique réalisée.

Etape 5

Le TEN test a été mesuré à l’aide des ASSEPs (ASSEP-TEN) chez 12 adultes et cinq enfants normo-entendants. Les données adultes ont été confrontées aux données comportementales. L’effet des stimuli ASSEP (son pur modulé en amplitude) sur les TEN test a également été investigué en comparant les données comportementales obtenues avec une sinusoïde et avec une sinusoïde modulée en amplitude chez 24 adultes.

Les seuils masqués enregistrés aux ASSEPs étaient supérieurs à ceux mesurés par une épreuve comportementale. L’élévation des seuils masqués pose un problème potentiel de dynamique.

La procédure doit être testée chez des patients présentant une surdité cochléaire attendu que la différence entre les seuils auditifs mesurés aux ASSEPs et par une épreuve comportementale est moindre dans cette population. Dans la mesure où le problème de dynamique résiduelle persiste chez les patients malentendants, d’autres stimuli ou algorithmes d’enregistrement doivent être utilisés.

Etape 6

Le TEN est un stimulus large bande. Il peut dès lors se révéler intolérable chez des patients présentant une atteinte auditive restreinte à une region fréquentielle. L’effet du filtrage du TEN sur les seuils et la sonie du TEN a été étudié chez 24 sujets normo-entendants et 35 patients présentant une perte cochléaire dans les hautes fréquences.

Le filtrage passe-haut du TEN s’est avéré être une solution satisfaisante.

Ces données ont été publiées dans International Journal of Audiology (Markessis et al. 2006; 45: 91-98).

Etape 7

L’effet de l’intensité du TEN sur le diagnostic des zones neuro-épithéliales non fonctionnelles a été investigué chez 24 patients en mesurant les seuils masqués à quatre intensités de TEN différentes. La fiabilité du TEN test a également été évaluée.

Le TEN est une procédure fiable. L’intensité du TEN a affecté le diagnostic chez cinq patients. Ce résultat est interprété en termes de degré de l’atteinte du complexe neurosensoriel.

Ces données ont été publiées dans International Journal of Audiology (Markessis et al. 2009; 48: 55-62).

Conclusion

Un algorithme permettant la mesure de TC et du TEN test objective à l’aide des ASSEPs a été développé. L’implémentation clinique de l’algorithme appliqué à l’enregistrement des CA paraît envisageable. Une importante étape de la corrélation entre modifications anatomiques (à l’aide de l’histopathologie) et physiologiques (ASSEP-TC et CAP-TC) est maintenant celle qui s’impose. Les données préliminaires obtenues sur le TEN test électrophysiologique chez des sujets normo-entendants suggèrent que son implémentation clinique puisse se heurter à un problème de dynamique si ce dernier est confirmé en présence de surdités cochléaires. Plusieurs pistes potentielles de solutions ont été avancées.


Doctorat en Sciences biomédicales et pharmaceutiques
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Books on the topic "Cochlea development"

1

Eby, Thomas L. Development of the facial recess: Implications for cochlear implantation. St. Louis, MO: American Laryngological, Rhinological and Otological Society, 1996.

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NIH Consensus Development Conference on Cochlear Implants in Adults and Children (1995 Bethesda, Md.). NIH Consensus Development Conference on Cochlear Implants in Adults and Children. Bethesda, MD: National Institutes of Health, 1995.

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H, Wada, ed. Proceedings of the International Symposium on Recent Developments in Auditory Mechanics. Singapore: World Scientific, 2000.

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Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Amsterdam: Elsevier, 1996.

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Bondarew, Veronica, and Peter Seligman. Cochlear Story. CSIRO Publishing, 2012. http://dx.doi.org/10.1071/9780643097520.

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Cochlear Ltd, together with its university partner and many other collaborators, has returned hearing to over 160 000 people thanks to the development of its hearing implant. This book documents the human story behind that development. It delves into the commercial planning and implementation that led to the product’s success in an international, highly competitive market, and the human drama that was experienced in achieving it. Chapters are structured around the development of the science. Woven within that structure are the personal and business stories that have enabled successful outcomes in the relatively new age of biomedical engineering. The Cochlear Story aims to put this Australian development on the world map in recognition of Australian medicine, science, technology and business. New from CSIRO PUBLISHING, the Bright Ideas series explores the innovation, application and continuing impact of major scientific inventions throughout history. From the compass to the bionic ear, each book will provide a fascinating and accessible story on a single invention that has changed our everyday lives.
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Goodyer, Paul. Kidney/ear syndromes. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0170.

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Malformations of the external ear may signal renal disease, but it is actually the disorders of the inner ear which reflect molecular pathways that are also crucial for kidney development. In a number of monogenic renal diseases, renal dysplasia is associated with deafness. Disorders of the kidney and inner ear are also linked in complex syndromes such as the human ciliopathies. In some cases, the loss of specific genes affects shared transport physiology, basement membrane assembly, or energy metabolism.The kidney and cochlea have a common susceptibility to toxins that are selectively concentrated by comparable uptake mechanisms in the two tissues.This chapter provides an overview of the many ways in which pathologies of the two organs are linked.
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P, Haggard M., Page M. L, Duphar Medical Relations, and Royal College of Physicians of London., eds. Clinical developments in cochlear implants. Southampton: Duphar Medical Relations, 1990.

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Kronenberger, William G., and David B. Pisoni. Neurocognitive Functioning in Deaf Children with Cochlear Implants. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190880545.003.0016.

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Cochlear implantation restores some attributes of hearing and spoken language to prelingually deaf children. However, reduced access to auditory and spoken-language experiences for children with cochlear implants can alter the development of downstream neurocognitive functions such as sequential processing and self-regulatory language skills, which are critical building blocks for executive functioning. Executive functioning is the active regulation of cognitive, behavioral, and emotional processes in the service of planned, organized, controlled, goal-driven behavior. This chapter presents findings from two primary lines of research on the development of executive functioning in prelingually deaf, early implanted children with cochlear implants. The first is identification of specific executive function domains that are at risk for delay in children with cochlear implants compared to hearing children. The second is reciprocal influences of executive function and spoken-language skills throughout development in children and adolescents with cochlear implants.
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Marozeau, Jeremy, Charles J. Limb, and Alexandre Lehmann, eds. Music and Cochlear Implants: Recent Developments and Continued Challenges. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88971-434-6.

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Kandler, Karl, ed. The Oxford Handbook of the Auditory Brainstem. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190849061.001.0001.

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The Oxford Handbook of the Auditory Brainstem provides an in-depth reference to the organization and function of ascending and descending auditory pathways in the mammalian brainstem. Individual chapters are organized along the auditory pathway, beginning with the cochlea and ending with the auditory midbrain. Each chapter provides an introduction to the respective area and summarizes our current knowledge before discussing the disputes and challenges that the field currently faces.The handbook emphasizes the numerous forms of plasticity that are increasingly observed in many areas of the auditory brainstem. Several chapters focus on neuronal modulation of function and plasticity on the synaptic, neuronal, and circuit level, especially during development, aging, and following peripheral hearing loss. In addition, the book addresses the role of trauma-induced maladaptive plasticity with respect to its contribution in generating central hearing dysfunction, such as hyperacusis and tinnitus.The book is intended for students and postdoctoral fellows starting in the auditory field and for researchers of related fields who wish to get an authoritative and up-to-date summary of the current state of auditory brainstem research. For clinical practitioners in audiology, otolaryngology, and neurology, the book is a valuable resource of information about the neuronal mechanisms that are currently discussed as major candidates for the generation of central hearing dysfunction.
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Book chapters on the topic "Cochlea development"

1

Groves, Andrew K., and Donna M. Fekete. "New Directions in Cochlear Development." In Understanding the Cochlea, 33–73. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-52073-5_3.

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Goodrich, Lisa V. "Early Development of the Spiral Ganglion." In The Primary Auditory Neurons of the Mammalian Cochlea, 11–48. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-3031-9_2.

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Pujol, R., M. Lavigne-Rebillard, and M. Lenoir. "Development of Sensory and Neural Structures in the Mammalian Cochlea." In Development of the Auditory System, 146–92. New York, NY: Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4612-2186-9_4.

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Nogueira, Waldo, Waldemar Würfel, Richard T. Penninger, and Andreas Büchner. "Development of a Model of the Electrically Stimulated Cochlea." In Biomedical Technology, 145–61. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10981-7_10.

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Jung, Young, Jun-Hyuk Kwak, Hanmi Kang, Wandoo Kim, and Shin Hur. "Development of Piezoelectric Artificial Cochlea Inspired by Human Hearing Organ." In Biomimetic and Biohybrid Systems, 145–52. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22979-9_15.

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Fritzsch, Bernd, Jennifer Kersigo, Tian Yang, Israt Jahan, and Ning Pan. "Neurotrophic Factor Function During Ear Development: Expression Changes Define Critical Phases for Neuronal Viability." In The Primary Auditory Neurons of the Mammalian Cochlea, 49–84. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-3031-9_3.

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Dabdoub, Alain, and Bernd Fritzsch. "Connecting the Inner Ear to the Central Auditory System: Molecular Development and Characteristics of the Primary Auditory Neurons and Their Network." In The Primary Auditory Neurons of the Mammalian Cochlea, 1–10. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-3031-9_1.

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Cakir, Ahmet, Benoit M. Dawant, and Jack H. Noble. "Development of a $$\upmu $$CT-based Patient-Specific Model of the Electrically Stimulated Cochlea." In Medical Image Computing and Computer Assisted Intervention − MICCAI 2017, 773–80. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-66182-7_88.

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Kaga, Kimitaka. "Gestational Development of the Human Auditory System Including the Cochlea and the Central Auditory Pathways." In ABRs and Electrically Evoked ABRs in Children, 39–49. Tokyo: Springer Japan, 2022. http://dx.doi.org/10.1007/978-4-431-54189-9_3.

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Tateya, Tomoko. "Cochlear Development." In Regenerative Medicine for the Inner Ear, 101–13. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54862-1_12.

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Conference papers on the topic "Cochlea development"

1

Steele, Charles R., Alissa Fitzgerald, Thomas Kenny, Kian-Meng Lim, and Sunil Puria. "Possibilities for a Silicon Model of the Cochlea." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1604.

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Abstract The purpose of this study is to resolve questions regarding the fundamental physical behavior of the cochlea of the inner ear. We seek a convergence of measurement and computation on physical models that capture essential features. Since there are unique features in the performance of the cochlea, the physical models could lead to device development. A much longer-term goal is a device for the assistance of hearing impaired individuals. The cochlea can be modeled as a tube of fluid divided by a partition, a portion of which is elastic and called the basilar membrane (BM). In preliminary work, the cochlear partition is constructed on a silicon wafer using current capabilities for micro-machining. The silicon nitride partition is inserted into a chamber of Plexiglas which is filled with solute and has a “stapes” for acoustic input and a “round window”. The silicon BM has the correct length, but is wider and isotropic. The measurements, supported by calculations, show that the deviation from the actual structure has a detrimental effect on the sharpness of the spatial distribution of the response for a fixed input frequency. Possibilities for improved models and for an active non-linear model with distributed sensors and actuators are discussed.
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Lehmann, M., S. Dazert, and S. Volkenstein. "The demographic change in the cochlea implant population – development over the first 1000 implantations." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640449.

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Liu, Derek, Wihan Kim, Sangmin Kim, Kumara Ratnayake, Scott Mattison, John S. Oghalai, and Brian E. Applegate. "Development of a 3-D vibrometry system for vector of motion measurements in the living cochlea." In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, edited by Joseph A. Izatt and James G. Fujimoto. SPIE, 2022. http://dx.doi.org/10.1117/12.2612280.

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Joyce, Bryan S., and Pablo A. Tarazaga. "Active Artificial Hair Cells Using Nonlinear Feedback Control." In ASME 2014 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/smasis2014-7419.

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There is interest in developing devices that mimic the sound transduction of the cochlear hair cells. Current artificial hair cell (AHC) designs have focused on passive transduction of sound into electrical signals. However, measurements inside living cochleae have revealed that a nonlinear amplification is at work in mammalian hearing. This amplification lowers the threshold for sound detection allowing mammals to hear faint sounds. The nonlinearity results in an amplitude compression whereby a large range of sound pressure levels produces a smaller range of displacements. This compressive nonlinearity gives the ear a large dynamic range. This work seeks to develop and analyze active artificial hair cells which employ a bio-inspired amplification to improve performance. This paper examines two artificial hair cell designs. The first is an 18.5 in long aluminum cantilever beam which is excited and controlled using piezoelectric actuators along the length of the beam. The second design is a one inch piezoelectric bimorph beam subject to a base excitation. In both cases a nonlinear feedback control law is implemented which reduces the beam’s linear viscous damping and introduces a cubic damping term. Model and experimental results show the control law amplified the response of the artificial hair cell to low excitation levels near the resonance frequency. Increasing input levels produced a compressive nonlinearity at resonance similar to that observed in measurements from mammalian cochleae. This work could lead to the development of new bio-inspired sensors with a lower threshold of detection, improved frequency sensitivity, and larger dynamic range.
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Richter, Claus-Peter, Changyow Claire Kwan, Xiaodong Tan, Stuart R. Stock, Carmen Soriano Hoyuelos, and Xianghui Xiao. "Microanatomy of the cochlear hook." In Developments in X-Ray Tomography XI, edited by Bert Müller and Ge Wang. SPIE, 2017. http://dx.doi.org/10.1117/12.2275187.

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Lawand, Nishant S., Paddy J. French, J. J. Briaire, and J. H. M. Frijns. "Development of probes for cochlear implants." In 2011 IEEE Sensors. IEEE, 2011. http://dx.doi.org/10.1109/icsens.2011.6127178.

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OVERSTREET, III, E. H., A. N. TEMCHIN, and M. A. RUGGERO. "DEVELOPMENT OF COCHLEAR MECHANICS IN THE GERBIL." In Proceedings of the International Symposium. WORLD SCIENTIFIC, 2003. http://dx.doi.org/10.1142/9789812704931_0030.

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Ngelayang, Thailis Bounya Anak, and Rhonira Latif. "Development of micro-electromechanical system (MEMS) cochlear biomodel." In INTERNATIONAL CONFERENCE ON MATHEMATICS, ENGINEERING AND INDUSTRIAL APPLICATIONS 2014 (ICoMEIA 2014). AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4915808.

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Gesink, S. "Impedance-development with direct-fitting after cochlear implantation." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686376.

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Hatzigiannakoglou, Paul, and Areti Okalidou. "A MOBILE-BASED REHABILITATION VR AND AR SERIOUS GAME FOR COCHLEAR IMPLANTED CHILDREN." In International Technology, Education and Development Conference. IATED, 2017. http://dx.doi.org/10.21125/inted.2017.0959.

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