Academic literature on the topic 'Cocaine habit'

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Journal articles on the topic "Cocaine habit"

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Dalby, J. Thomas. "Sherlock Holmes's cocaine habit." Irish Journal of Psychological Medicine 8, no. 1 (March 1991): 73–74. http://dx.doi.org/10.1017/s0790966700016475.

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Duan, Ying, Lingtong Jin, Wenjie Du, Shubo Jin, Yiming Meng, Yonghui Li, Jianjun Zhang, Jing Liang, Nan Sui, and Fang Shen. "Alterations of Dopamine Receptors and the Adaptive Changes of L-Type Calcium Channel Subtypes Regulate Cocaine-Seeking Habit in Tree Shrew." Life 12, no. 7 (June 30, 2022): 984. http://dx.doi.org/10.3390/life12070984.

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The putamen (Put) is necessary for habitual actions, while the nucleus caudate (Cd) is critical for goal-directed actions. However, compared with the natural reward (such as sucrose)-seeking habit, how drug-related dysfunction or imbalance between the Put and Cd is involved in cocaine-seeking habit, which is not easy to bias behavior to goal-directed actions, is absent. Therefore, in our present study, in comparison with sucrose-habitual behavior, we evaluated the distinctive changes of the two subtypes of dopamine (DA) receptors (D1R and D2R) in cocaine-seeking habitual behavior animals. Moreover, the adaptive changes of Cav1.2 and Cav1.3, as prime downstream targets of D1R and D2R respectively, were also assessed. Our results showed that a similar percentage of the animals exhibited habitual seeking behavior after cocaine or sucrose variable-interval self-administration (SA) training in tree shrews. In addition, compared with animals with non-habitual behavior, animals with cocaine habitual behavior showed higher D1Rs and Cav1.2 expression in the Put accompanied with lower D2Rs and Cav1.3 expression in the Cd. However, after sucrose SA training, animals with habitual behavior only showed lower membrane expression of D2R in the Put than animals with non-habitual behavior. These results suggested that the upregulation of D1Rs-Cav1.2 signaling may lead to hyper-excitability of the Put, and the inactivation of D2Rs-Cav1.3 signaling may result in depressed activity in the Cd. This imbalance function between the Put and Cd, which causes an inability to shift between habits and goal-directed actions, may underlie the compulsive addiction habit.
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Ersche, K. D. "Habit formation in humans with cocaine addiction." European Neuropsychopharmacology 27 (October 2017): S531—S532. http://dx.doi.org/10.1016/s0924-977x(17)31007-6.

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&NA;. "Few kick the cocaine habit for good." Drugs & Therapy Perspectives 13, no. 8 (April 1999): 5–8. http://dx.doi.org/10.2165/00042310-199913080-00002.

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&NA;. "Bupropion helps crack the habit in cocaine addicts." Inpharma Weekly &NA;, no. 1535 (April 2006): 18. http://dx.doi.org/10.2165/00128413-200615350-00048.

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Miles, Felicity J., Barry J. Everitt, and Anthony Dickinson. "Oral cocaine seeking by rats: Action or habit?" Behavioral Neuroscience 117, no. 5 (2003): 927–38. http://dx.doi.org/10.1037/0735-7044.117.5.927.

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Sterk-Elifson, Claire. "Just for Fun?: Cocaine Use among Middle-Class Women." Journal of Drug Issues 26, no. 1 (January 1996): 63–76. http://dx.doi.org/10.1177/002204269602600105.

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The focus of this article is on middle-class female cocaine users. It explores the women's perspective and challenges the notion of cocaine use being a problem of poor, minority populations. The women were either introduced to cocaine by a male or female friend, mostly in the context of “just for fun.” Although all women continued to use cocaine, they had to develop their own cocaine connections and their use became less linked to personal relationships. Most women stressed that they had a “controlled” habit, although the nature of their use indicated that they were addicted. The women linked their control to the resources available to them to hide and support their cocaine use. They put much time and energy into trying to maintain these resources, however, they are not always successful. The findings reveal a need for further studies exploring drug use among middle-class women and the link between drug use and power or control.
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Terra Filho, Mário, Chen Chin Yen, Ubiratan de Paula Santos, and Daniel Romero Muñoz. "Pulmonary alterations in cocaine users." Sao Paulo Medical Journal 122, no. 1 (February 2004): 26–31. http://dx.doi.org/10.1590/s1516-31802004000100007.

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CONTEXT: Brazilian researchers have recently recognized a marked increase in the number of people using abusable drugs and the consequences of this habit. It has become a major public health problem in a potentially productive segment of the general population. In the last few years, several medical articles have given special emphasis to pulmonary complications related to cocaine use. This review is based on this information and experience acquired with groups of cocaine users. OBJECTIVE: To present to physicians the pulmonary aspects of cocaine use and warn about the various effects this drug has on the respiratory system, stressing those related to long-term use. DESIGN: Narrative review. METHOD: Pulmonary complications are described. These may include infections (Staphylococcus aureus, pulmonary tuberculosis, acquired immunodeficiency syndrome/aids, etc.), aspiration pneumonia, lung abscess, empyema, septic embolism, non-cardiogenic pulmonary edema, barotrauma, pulmonary granulomatosis, bronchiolitis obliterans and organizing pneumonia, pneumonitis and interstitial fibrosis, pneumonitis hypersensitivity, lung infiltrates and eosinophilia in individuals with bronchial hyperreactivity, diffuse alveolar hemorrhage, vasculitis, pulmonary infarction, pulmonary hypertension and alterations in gas exchange. It is concluded that physicians should give special attention to the various pulmonary and clinical manifestations related to cocaine use, particularly in young patients.
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Hamid, Ammar, and Priyanka Patel. "An unusual presentation of oro-naso-palatal fistula." Dental Update 46, no. 9 (October 2, 2019): 825–26. http://dx.doi.org/10.12968/denu.2019.46.9.825.

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This case report is of a 29-year-old male who complained of nasal escape of food and fluids through his nose for 6 months. Further questioning revealed a previous cocaine habit which has now ceased. Examination revealed a septal perforation and CT scanning revealed a 16 mm wide sagittal bone defect involving most of the hard palate as well as absence of the inferior half of the nasal septum. A diagnosis of septal perforation leading to an oro-naso-palatal fistula was made. This rather unusual presentation and clinical findings are discussed within this article. CPD/Clinical Relevance: The effects of cocaine misuse on the oral mucosa are presented.
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Pierce, R. Christopher, and Louk J. M. J. Vanderschuren. "Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction." Neuroscience & Biobehavioral Reviews 35, no. 2 (November 2010): 212–19. http://dx.doi.org/10.1016/j.neubiorev.2010.01.007.

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Dissertations / Theses on the topic "Cocaine habit"

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Miles, Felicity Jane. "Oral cocaine seeking in rats : action or habit?" Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620540.

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Javanmard, Sahar. "Synthesis and pharmacology of site-specific cocaine abuse treatment agents." Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/30952.

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Moore, Susanna. "Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5010.

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Synthesis and Pharmacology of Potential Site-Directed Therapeutic Agents for Cocaine Abuse Susanna Moore 235 Pages Directed by Dr. David M. Collard and Dr. Howard M. Deutsch Stimulants such as cocaine continue to dominate the nations illicit drug problem. An effective medication for any aspect of cocaine addiction has not been developed. Cocaine binds, although not selectively, to the dopamine transporter (DAT) and disrupts normal dopamine (DA) neurotransmission between neurons. While the dopamine hypothesis for the mechanism of action of cocaine has been widely accepted, cocaine also possesses the ability to block the uptake of serotonin at the serotonin transporter (5-HTT) and norepinephrine at the norepinephrine transporter (NET). The purpose of the work described herein is directed towards synthesizing and testing compounds selective for the DAT, leading to the identification of candidates as potential pharmacotherapies for cocaine dependence. A series of disubstituted and trisubstituted [2.2.2] and [2.2.1]bicycles were synthesized and tested for inhibitor potency in [3H]WIN 35,428 (WIN) binding at the DAT and for inhibition of [3H]DA uptake. Based on results from some of the pharmacology data new regio- and stereochemical isomers of bicyclic [2.2.1]heptanes and [2.2.2]octanes were synthesized. This will lead to further structure-activity-relationships, which will provide a better understanding of the structural requirements needed to bind at the DAT.
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Zhang, Liang. "Synthesis and pharmacology of site-specific cocaine abuse treatment agents : 2-(aminomethyl)-3-phenylbicyclo[221] and [221]-alkane dopamine uptake inhibitors." Thesis, Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/26015.

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Coons, Susanna. "Synthesis and pharmacology of site-specific cocaine abuse treatment agents : 6-(N,N-Dimethylamino)-5-(4-chlorophenyl)bicyclo[222]octan-2-yl benzoate." Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/27609.

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Howell, Simon Peter. "Force of habit the mystical foundations of the narcotic." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1002994.

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This thesis aims to investigate and deconstruct the relationship between the narcotic, its narrative, and western modernity. To reveal the relationship, this thesis argues that it is possible to understand the philosophical, political, cultural and ethical dimensions of western modernity through the ulterior lens of the narcotic. As such, this thesis investigates western modernity's relationship to (a) cocaine as a specific narcotic, and (b) the concept of the narcotic with all its attendant connotations of addictions, illegitimacy, transgression, illegality, and so on. Accordingly, the thesis is both interpretive of the historical narrative of the narcotic of cocaine, and generative in its deconstruction of the relationship between western modernity and the concept of the narcotic. The deconstruction of this relationship ultimately reveals both prior narratives not as oppositional, but as supplementary. This has radical consequences for the manner in which we engage with narcotic use and the user - if the narcotic is supplement to the logic of western modernity, at each attempt to expel the use and user of the narcotic, rather then create difference, we self implicate ourselves in that expulsion and distance. To seek a new and more just means of dealing with the concept of the narcotic, and its use, therefore requires a new epistemological framework which can at once contemplate both narratives at the same time. To this end, the thesis suggests the use of critical complexity theory as one such methodological tool, if supplemented by the thoughts and strategies of Derridian deconstruction and Foucauldian discourse analysis.
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Williamson, Anna Public Health &amp Community Medicine Faculty of Medicine UNSW. "The effect of cocaine use on outcomes for the treatment of heroin dependence in Sydney, Australia." Awarded by:University of New South Wales. School of Public Health and Community Medicine, 2005. http://handle.unsw.edu.au/1959.4/24973.

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This thesis explored the effect of cocaine use on treatment outcomes for heroin dependent individuals in Sydney, Australia. A naturalistic, longitudinal design was employed in order to examine the effects of cocaine on outcomes over a two year period. Study 1 assessed the prevalence and correlates of cocaine use among heroin dependent individuals. Cocaine use was found to be common among entrants to all three of the major treatment modalities in NSW. Heroin users who also used cocaine (CU) displayed a poorer clinical profile at baseline than non-cocaine users (NCU), reporting higher levels of drug use and dependence, and a greater prevalence of needle risk-taking and criminal behaviour. Study 2 examined outcomes three months post-study entry. CU and NCU were found to have been equally well retained in treatment. Despite significantly reduced levels of cocaine use amongst the cohort, however, CU continued to display the higher levels of drug-related harm that characterized them at baseline. In order to determine whether cocaine use itself was responsible for the greater levels of harm observed amongst CU, or whether instead CU were an inherently more dysfunctional group for whom cocaine use merely served as a marker, comparisons were made within groups on the basis of cocaine use patterns over the study period. The results of these analyses demonstrated that commencing cocaine use resulted in a clear decline in functioning, whereas cessation resulted in corresponding improvements. In Study 3 outcomes were examined twelve months post-study. Baseline cocaine use was again found to predict poorer outcome, despite a large scale reduction in cocaine use amongst the cohort. Importantly, CU were significantly less likely than NCU to be abstinent from heroin at twelve months and more likely to have been incarcerated since study entry. In addition, the effect of persistence of cocaine use was examined. Results indicated that the harms associated with cocaine use increased with increasing persistence of use. Outcomes at two years post-study entry were explored in Study 4. At this time CU and NCU recorded similar outcomes in most domains. Thus, it appeared that the harms caused by cocaine use may take a substantial period of time to diminish. Patterns of cocaine use and motivations for cessation and commencement were also examined. Responses suggested that cocaine use amongst the cohort was largely opportunistic, with participants ceasing use for a variety of reasons, including the financial and psychological problems caused by cocaine use. Past year prevalence of cocaine dependence was measured in this study, with the majority of those who had used cocaine in the past year meeting criteria for dependence. In Study 5, generalized estimating equations were used to measure the effect of baseline cocaine use on major outcome variables over the entire two year study period. Even after controlling for treatment variables, heroin use and other baseline polydrug use, the results of this study confirmed previous findings within the thesis by demonstrating the negative effect of baseline cocaine use on most outcome variables. Evidently, cocaine use among dependent heroin users has serious, long lasting, consequences. To date, however, there has been a stark lack of research examining the effect of cocaine use on treatment outcomes for heroin dependence. To that end, the results of this thesis are encouraging, suggesting that treatment for heroin dependence may also aid in reducing cocaine use among this group.
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Bain, Katherine Alison. "Chased by the dragon the experience of relapse in cocaine and heroin users /." Diss., Pretoria : [s.n.], 2004. http://upetd.up.ac.za/thesis/available/etd-10192004-100341.

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Gonzalez, Marin Maria del Carmen. "Habits in relapse : role of the discriminative stimulus properties of drugs of abuse in behavioral automatisms." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR22009/document.

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L’addiction aux drogues peut être considérée comme une maladie neurologique chronique avec des rechutes récurrentes en période d’abstinence qui constituent le problème majeur dans le traitement de l’addiction aux drogues. Grâce à un modèle animal de rechute, il a été montré qu’un rongeur pouvait réinstaller un comportement de recherche de drogue lorsqu’il était réexposé à la drogue elle-même, à des indices associés à la drogue, ou encore à un stress. Dans notre équipe, nous avons évalué la contribution relative des différentes propriétés de la cocaïne, de l’héroïne et de la nicotine (incitative, discriminative et renforçante) dans la réinstallation d’un comportement de recherche de nourriture. Afin de dissocier les propriétés discriminatives et renforçantes, les rats ont été entraînés à s’auto-administrer une récompense alimentaire. Nous avons alors trouvé que : 1) La cocaïne et la nicotine agissent comme des stimuli internes qui acquièrent un contrôle discriminatif sur le comportement, étant donné que la cocaïne et la nicotine, contrairement à l’héroïne, peuvent réinstaller un comportement éteint de recherche de nourriture lorsque ce comportement a été préalablement acquis sous les effets de la cocaïne et de la nicotine, respectivement. 2) La réinstallation induite par la cocaïne et la nicotine est indépendante de la valeur actuelle de la récompense, ce qui indique que la cocaïne et la nicotine contrôlent l’activation de comportements automatiques, habituels, liés à la drogue. Puis, afin d’identifier la façon dont les drogues d’abus entraînent la formation d’habitudes, nous avons également étudié les effets d’une sensibilisation à la cocaïne à différents moments d’un apprentissage instrumental pour une récompense alimentaire, après une dévaluation de la récompense. Nous avons alors trouvé que la sensibilisation à la cocaïne ne favorisait pas le développement de comportements de type habituel. Cette série d’expériences constitue une première étape dans la comparaison des processus automatiques produits par la cocaïne et la nicotine. Si l’activation de comportements de type habituel, automatique, peut être généralisée à d’autres drogues d’abus, nous pourrons considérer que la rechute vers la recherche et la prise de drogue est en partie sous le contrôle de processus automatiques, ce qui pourrait expliquer la forte probabilité de rechute, même après de longues périodes d’abstinence et malgré la connaissance des conséquences néfastes qui en découlent
Drug addiction can be considered as a chronic brain disease with recurrent relapse during abstinence periods which remains the major problem for the treatment of drug addiction. Using an animal model of drug relapse, it has been shown that a rodent can reinstate a drug-seeking behavior when re-exposed to the drug itself, drug associated cues or stress. In our research group, we assessed the relative contribution of the different properties of cocaine, heroin and nicotine (incentive, discriminative and reinforcing) in food-seeking reinstatement, and in order to dissociate the discriminative from the reinforcing properties, rats were trained to self-administer a non-drug reward (food). We found that: 1) Cocaine and nicotine act as internal stimuli that acquires discriminative control over behavior, since cocaine and nicotine, but not heroin, can reinstate an extinguished food-seeking behavior when this behavior has been previously performed under the effects of cocaine and nicotine respectively. 2) Cocaine- and nicotine-induced reinstatement is independent of the current value of the outcome, which indicates that cocaine and nicotine control the activation of automatic, drug-related habitual behaviors. Then, in order to identify the way drugs of abuse lead to the formation of habits, we also examined the effects of cocaine sensitization at different stages of instrumental training for a food reward after outcome devaluation. We found that, globally, cocaine sensitization does not promote the development of habit-based behaviors. This series of experiments represent a first step in the comparison of automatic processes produced by cocaine and nicotine. If the activation of automatic, habit-based behaviors can be generalized to other drugs of abuse, we could consider that relapse to drug-seeking and drug-taking is partly under the control of automatic processes, which could explain the high probability of relapse, even after extended periods of abstinence and despite the knowledge of the adverse consequences
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De, Pirro Silvana. "Substance-specific modulation of the affective and neurobiological effects of heroin and cocaine in human addicts." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/71904/.

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This dissertation investigates how the settings of drug use influence the affective and neurobiological response to heroin versus cocaine in addicts. Chapter 1 reviews the neuropharmacology of heroin and cocaine and the theoretical background for drugs-settings interactions, including a detailed discussion of findings from previous studies in animals and humans that show how the same settings can influence in opposite directions the reinforcing effect of heroin and cocaine. Cocaine self-administration, for example, was greatly facilitated when rats were tested outside the home environment relative to rats test at home. The opposite pattern was found for heroin. Translational studies in humans yielded similar results. Indeed, heroin and cocaine co-abusers reported using the two drugs in distinct settings: heroin preferentially at home and cocaine preferentially outside the home. The aim of this dissertation is to determine whether the setting could also influence in opposite manner the affective and neurobiological response to heroin and cocaine in human addicts. Chapter 2 illustrates the findings of a study aimed at testing the hypothesis that the affective state experienced under cocaine or heroin is the result of an interaction between central and peripheral drug effects and the surroundings of drug use. According to this hypothesis, when cocaine is taken at home there is a mismatch between the familiar environment and the peripheral effects such as arousal, increased heart rate, increased respiratory rate, and increased muscular tension (which are usually produced in stressful situations). This mismatch dampens cocaine-rewarding effects. A mismatch would also occurs when heroin (which produces sedation and decreases heart rate, respiratory rate, and muscular tension) is used outside the home in contexts requiring vigilance. We found indeed that co-abusers subjectively experienced opposite changes in arousal, heart rate, respiratory rate, and muscular tension in response to cocaine (increase) versus heroin (decrease). Most important, using a novel two-dimensional visual test, we found that in agreement with the working hypothesis the valence of the affective state produced by heroin and cocaine shifted in opposite directions as a function of the setting of drug use: heroin was reported to be more pleasant at home than outside the home, and vice versa for cocaine. Chapter 3 illustrates the results of in which emotional imagery was combined with fMRI to investigation the neurobiological underpinnings of drug and setting interactions in addicts. Heroin and cocaine co-abusers were asked to recreate real-world settings of drug use during fMRI. In agreement with the working hypothesis, we found that heroin and cocaine imagery produced opposite changes in BOLD in the prefrontal cortex and in the striatum, regions implicated in brain reward in humans. Furthermore the same pattern of dissociation was observed in the cerebellum, suggesting that that a fronto-triatal-cerebellar network is implicated in processing drug-setting interactions. Chapter 4 includes a summary of the results, a general discussion, and suggestions for future research and implication. The major finding is that the environment surrounding drug use can influence in opposite manner the affective and neurobiological response to heroin and cocaine, suggesting that therapeutic approaches to the treatment of drug addiction should take into account the distinctive effects of different classes of drugs as well as the contexts of drug use. The Appendix includes reprints of two papers reporting on additional studies conducted during the course of the Ph.D. program, which are not directly germane to the aims of the dissertation. Other three papers are in the pre-submission stage.
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Books on the topic "Cocaine habit"

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Gold, Mark S. Cocaine. New York: PlenumMedical Book Co, 1993.

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Johanson, Chris-Ellyn. Cocaine: A new epidemic. London: Burke, 1988.

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Shaffer, Howard. Quitting cocaine: The struggle against impulse. Lexington, Mass: Lexington Books, 1989.

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Cocaine. New York: Rosen Pub. Group, 1991.

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McFarland, Rhoda. Cocaine. New York: Rosen Pub. Group, 2000.

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1942-, Mirin Steven M., ed. Cocaine. Washington, DC: American Psychiatric Press, 1987.

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Weiss, Roger D. Cocaine. Washington, DC: American Psychiatric Press, 1987.

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1942-, Mirin Steven M., and Bartel Roxanne L, eds. Cocaine. 2nd ed. Washington, DC: American Psychiatric Press, 1994.

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Cocaine. New York: Plenum Medical Book Co., 1993.

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Canada, Canada Health. Cocaine use: Recommendations in treatment and rehabilitation. Ottawa: Heatlh Canada, 2001.

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Book chapters on the topic "Cocaine habit"

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Gray, Elizabeth Kelly. "Federal Regulation Begins, 1875–1914." In Habit Forming, 194–218. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/oso/9780190073121.003.0010.

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Abstract States and municipalities began restricting opiate and cocaine sales in the 1870s; the US government followed, as it sought international cooperation to limit the drug trade. Numerous jurisdictions passed laws to reduce use. Although the Pure Food and Drug Act combated proprietary medicines, many regarded drug regulation as a state matter. In 1898, however, the nation annexed the Philippines and sought to end drug use there. This required international cooperation, and the United States passed domestic legislation to underscore its anti-drug commitment. The 1909 Smoking Opium Act restricted imports, and the 1914 Harrison Anti-Narcotic Act required prescriptions for cocaine and opiate sales. Prejudice bolstered support. Many associated cocaine use with black men, and many American opiate users were young, working-class men using heroin. Meanwhile, in the West there were bans on marijuana, whose perceived users were Mexican immigrants, and efforts to ban peyote, which some Native Americans used.
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Malleck, Dan. "W. A. Hammond, ‘Remarks on Cocaine and the So-called Cocaine Habit’, Journal of Nervous and Mental Disease, 13, 1886, 754–58." In Drugs, Alcohol and Addiction in the Long Nineteenth Century, 127–30. Routledge, 2020. http://dx.doi.org/10.4324/9780429436109-23.

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Manic, Mihajlo. "The Influence of Internet Addiction on the Mental Health of Young People." In Fighting for Empowerment in an Age of Violence, 211–17. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-4964-6.ch012.

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The author points out that the intensive use of the internet and its “charm” in recent years have led to the emergence of a phenomenon known as “internet addiction.” The internet itself is a harmless tool, but improper use of the network can increase the risk of addiction, mental health, and social relations disorders. Most people think that addiction is related only to the use of chemical compounds such as alcohol, nicotine, cocaine, and heroin, but experts believe that anything that stimulates a human being and makes them feel energetic can be addictive. Addiction treatment is not limited to drug therapy. Whenever a habit becomes compulsive, such as gambling, drugs, alcohol, or even playing computer games, chatting, surfing the web, it can also be considered addictive. Behavioral addictions should not be neglected due to lack of “material.” What makes people addicted is a pleasant experience in performing that behavior, just as addicts feel when they use chemical drugs.
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"THE RISE AND FALL AND RISE OF COCAINE IN THE UNITED STATES." In Consuming Habits, 215–37. Routledge, 2005. http://dx.doi.org/10.4324/9780203993163-18.

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Malleck, Dan. "‘The Prevalence of the Morphin and Cocain Habits’, Jama, 60, 1913, 1363–64." In Drugs, Alcohol and Addiction in the Long Nineteenth Century, 366–67. Routledge, 2020. http://dx.doi.org/10.4324/9780429436079-39.

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