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Journal articles on the topic 'Coagulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 September 2024

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1

Xiao, Shu Hu, Yong Hui Song, Ping Zeng, Jian Feng Peng, and Dong Sheng Zhang. "Comparative Study on the Treatment of Berberine Wastewater by Chemical- and Electro-Coagulation Processes: Zeta Potential Analysis." Advanced Materials Research 599 (November 2012): 496–500. http://dx.doi.org/10.4028/www.scientific.net/amr.599.496.

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The comparative study on treating the berberine pharmaceutical wastewater by chemical-coagulation and electro-coagulation was carried out, and the Zeta potential, ζ was analyzed to reveal the coagulation mechanisms. The results indicated that electro-coagulation and pulse electro-coagulation could be more effective than traditional chemical-coagulation for berberine removal from wastewater: the removal efficiencies of electro-coagulation and pulse electro-coagulation processes reached above 87.6%, while the removal efficiencies were lower than 35% for the PFS and PAC coagulations. The ζ potential analysis revealed that charge neutralization was the main mechanisms for berberine removal.

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2

Bergdahl, Björn, and Bertil Vällfors. "Studies on coagulation and the development of an automatic computerized bipolar coagulator." Journal of Neurosurgery 75, no. 1 (July 1991): 148–51. http://dx.doi.org/10.3171/jns.1991.75.1.0148.

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✓ A new computerized bipolar coagulator is described in which tissue heating is switched off automatically when adequate vessel occlusion has been achieved, thus preventing overheating, undue tissue damage, cutting, and sticking of the forceps. Experiments with radiofrequency (rf) heating of albumin or arteries revealed an impedance minimum at the moment of coagulation. The attainment of this impedance minimum is transmitted electronically via a microprocessor to the coagulator, which automatically shuts off the rf energy supply. In experiments, adequate artery strength and avoidance of the drawbacks of conventional coagulation methods were achieved when rf heating was shut off soon after the impedance minimum was reached. Neither irrigation for cooling nor cleaning of the forceps tips was necessary. Electronic feedback through the same cables as used for coagulation enabled the use of conventional bipolar cables and forceps. The bipolar coagulator described can also be used for conventional bipolar coagulation under visual control. The microcomputer enables: 1) automatic coagulation cycles that start when tissue is picked up in the forceps and stop automatically on completion of the seal; 2) the change of power setting from a pedal and activation of automatic cycles by the pedal as described above or surgeon-controlled coagulation, which facilitates the use of alternative debridement with inactive forceps; 3) cable testing; and 4) negligible disturbance of the intraoperative monitoring equipment.

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3

Hallén, Elin, Anne Lundén, Anna-Maria Tyrisevä, Maria Westerlind, and Anders Andrén. "Composition of poorly and non-coagulating bovine milk and effect of calcium addition." Journal of Dairy Research 77, no. 4 (September 8, 2010): 398–403. http://dx.doi.org/10.1017/s0022029910000671.

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Ninety-nine individual milk samples from 37 cows in lactation week 10–35, selected for producing well or poorly/non-coagulating milk, were compared regarding protein composition, total calcium content, casein micelle size, pH, and coagulating properties after addition of 0·05% CaCl2. The results showed that a low κ-casein concentration in milk was a risk factor for non-coagulation. CaCl2 addition improved coagulating properties (coagulation time, curd firmness) of nearly all samples and eliminated differences between poorly/non-coagulating and well-coagulating milk, particularly regarding curd firmness. A second, independent data set with 18 non-coagulating or well-coagulating milk samples were analysed for protein composition, where indications of a similar association with κ-casein was observed.

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4

Tian, Chenhao, Yuehan Wu, Mingzhi Wei, and Chenghong Feng. "A novel understanding of residual nano-Al13 formation and degradation during coagulation and flocculation: a proof based on ESI-TOF-MS." Environmental Science: Nano 5, no. 11 (2018): 2712–21. http://dx.doi.org/10.1039/c8en00921j.

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Nano-Al₁₃ species changes in coagulation can be detected by optimized ESI-MS. Al₁₃ clusters can be aggregated by Al_m and Al_o instantly in AlCl₃ coagulation. Al₁₃ clusters are efficient components in both AlCl₃ and PACl coagulations.

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5

Pazzola, Michele. "Coagulation Traits of Sheep and Goat Milk." Animals 9, no. 8 (August 8, 2019): 540. http://dx.doi.org/10.3390/ani9080540.

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Milk production from sheep and goat species is continuously growing worldwide, and its main use is for cheesemaking. Given that the final quality of cheese is linked to the traits of raw milk cheese yield at dairy plants, it is often calculated by using predictive formulas based on fat and protein content. Predictive formulas have been studied for bovine milk and are very effective but not appropriate for sheep and goat milk. Several methods, which simulate the actual coagulation processes, are available at the laboratories. This article reviews the available literature about rennet coagulation and cheese yield traits from sheep and goat milk and the methods used at the laboratory level. In general, if compared to cow milk, sheep and goat milk are characterized by shorter rennet coagulation times and a very limited amount of non-coagulating samples. Curd firmness of sheep milk is almost independent from the rennet coagulation time, and some coagulation traits can be predicted by infrared spectra. In addition, coagulation traits are characterized by appropriate values of heritability to be considered in selective breeding plans. With regard to goat milk, rennet coagulation time and cheese yield are strongly influenced by the breed effect.

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6

Yanada, H., N. Nishimura, and T. Imagawa. "Acceleration of coagulation of particles in oil utilizing an a.c. electric field." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 218, no. 3 (March 1, 2004): 317–26. http://dx.doi.org/10.1243/095440604322900444.

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This paper describes an experimental investigation of the coagulation of particles in oil accelerated by the action of an a.c. electric field. The ultimate goal of the investigation is to develop a high-performance electrostatic filter for insulating liquids. In order to reveal the coagulation mechanism and find out the mechanical conditions suitable for the coagulation, the effects of various factors on the coagulation are investigated using spherical silica particles of 2, 4 and 6 μm in diameter. The coagulating state of the silica particles in oil is observed using a video-microscope with a CCD (charge coupled device) camera under various conditions. It is shown that the coagulation is better promoted with larger particles and that the particles having a small diameter are not easily coagulated. It is also shown that the oscillation amplitude relative to the double-layer thickness dominates the coagulation phenomenon. The experimental results suggest that when the surface charge on a particle and the charge in the surrounding double layer are appropriately polarized by the influence of the a.c. electric field, the coagulation is accelerated by virtue of a (relatively) strong attractive force acting between two-particle-double-layer pairs.

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7

Galeeva, N. V., and I. E. Kravchenko. "INDICATORS OF HEMOSTASIS IN PATIENTS WITH CHRONIC HEPATITIS C." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 6 (December 15, 2018): 279–85. http://dx.doi.org/10.18821/1560-9529-2018-23-6-279-285.

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Goal of the study is to reveal the particular features of hemostasis in patients with chronic hepatitis C in dynamics of natural course of disease. Materials and methods. The indices of hemostasis in 535 patients with chronic hepatitis C were assessed by the number of platelets, degree of their aggregation with the use of inductor of adenosine triphosphate and without it (spontaneous aggregation of platelets). Coagulative hemostasis was analyzed by the activated partial thromboplastin time, antitrombin III, prothrombin ratio, prothrombin time, fibrinogen concentration in plasma and international normalized ratio. Based on the number of Tr, typical for the disseminated intravascular coagulation syndrome, conditionally the patients were divided into 3 groups: I group - hypercoagulability; II - transient phase between hyper and hypocoagulation and III- hypocoagulation, which also included patients with liver cirrhosis. Results and discussion. Independent on the phase of disseminated intravascular coagulation syndrome, increase of aggregation of Tr with the growth of maximal amplitude was observed. The main part of studied indices of coagulative hemostasis indicated at the condition of hypocoagulation in patients with chronic hepatitis C - this is significant increase of activated partial thromboplastin time, prothrombin time, international normalized ratio and decrease of fibrinogen concentration in the studied groups by the phases of disseminated intravascular coagulation syndrome. Value of antitrombin III changed oppositely, it decreased, so that plasma hemostasis tends to the hypercoagulation. Conclusion. Under the chronic hepatitis C all phases of disseminated intravascular coagulation syndrome were observed with the disorder of thrombocytic coagulative hemostasis. There was followed up multidirectional change of hemostasis which obtained in the most cases character of delitescent course of disseminated intravascular coagulation syndrome.

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8

Galeeva, N. V., and I. E. Kravchenko. "INDICATORS OF HEMOSTASIS IN PATIENTS WITH CHRONIC HEPATITIS C." Epidemiology and Infectious Diseases (Russian Journal) 23, no. 6 (December 15, 2018): 279–85. http://dx.doi.org/10.18821/1560-9529-2019-23-6-279-285.

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Goal of the study is to reveal the particular features of hemostasis in patients with chronic hepatitis C in dynamics of natural course of disease. Materials and methods. The indices of hemostasis in 535 patients with chronic hepatitis C were assessed by the number of platelets, degree of their aggregation with the use of inductor of adenosine triphosphate and without it (spontaneous aggregation of platelets). Coagulative hemostasis was analyzed by the activated partial thromboplastin time, antitrombin III, prothrombin ratio, prothrombin time, fibrinogen concentration in plasma and international normalized ratio. Based on the number of Tr, typical for the disseminated intravascular coagulation syndrome, conditionally the patients were divided into 3 groups: I group - hypercoagulability; II - transient phase between hyper and hypocoagulation and III- hypocoagulation, which also included patients with liver cirrhosis. Results and discussion. Independent on the phase of disseminated intravascular coagulation syndrome, increase of aggregation of Tr with the growth of maximal amplitude was observed. The main part of studied indices of coagulative hemostasis indicated at the condition of hypocoagulation in patients with chronic hepatitis C - this is significant increase of activated partial thromboplastin time, prothrombin time, international normalized ratio and decrease of fibrinogen concentration in the studied groups by the phases of disseminated intravascular coagulation syndrome. Value of antitrombin III changed oppositely, it decreased, so that plasma hemostasis tends to the hypercoagulation. Conclusion. Under the chronic hepatitis C all phases of disseminated intravascular coagulation syndrome were observed with the disorder of thrombocytic coagulative hemostasis. There was followed up multidirectional change of hemostasis which obtained in the most cases character of delitescent course of disseminated intravascular coagulation syndrome.

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9

Fu, Yong. "The Forming Mechanism of a New Oil-Mineral Aggregate." Advanced Materials Research 211-212 (February 2011): 1176–81. http://dx.doi.org/10.4028/www.scientific.net/amr.211-212.1176.

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A new Oil-Mineral Aggregate with bentonite and calsium hydroxide and sawdust has been done. Through several dozens of experiments, the coagulation efficiency with bentonite and Ca(OH)2 and sawdust is 94.53%. The functions of bentonite are coagulation, adsorption and emulsification. Calsium hydroxide is a good coagulant-mate, and strengthen the coagulating function of bentonite. It can be used as the source of calcium ions, which can strongly adsorb on both bentonite and oil droplets, and is helpful for the coagulation between bentonite and oil droplets. Sawdust is also very important in the OMA, its fouctions are buoyant, bridge-made and adsorbant.

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10

Okazaki, Masako, Hideharu Sakamoto, Makoto Suzuki, and Katsuji Oguchi. "Effects of Single and Multiple Moxibustions on Activity of Platelet Function, Blood Coagulation and Fibrinolysis in Mice." American Journal of Chinese Medicine 18, no. 01n02 (January 1990): 77–85. http://dx.doi.org/10.1142/s0192415x90000113.

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The effects of single and multiple moxibustions on platelet function, blood coagulation and fibrinolytic activity in ddY mice were studied. The increase in platelet aggregation and ATP-release after a single moxibustion was dependent on moxa weight and the kind of platelet stimulus. Blood coagulative activity tended to increase in the early phase after a single moxibustion. However, multiple moxibustions maintained the homeostasis on blood coagulation and fibrinolytic activiity. This investigation suggests that the effects of moxibustion on platelet functions and coagulative and fibrinolytic activities cause an enhancement of the phagocytic activity in the host defense mechanism.

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11

Granovsky, Boris L., and Alexander V. Kryvoshaev. "Coagulation Processes with Gibbsian Time Evolution." Journal of Applied Probability 49, no. 3 (September 2012): 612–26. http://dx.doi.org/10.1239/jap/1346955321.

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We prove that a stochastic process of pure coagulation has at any time t ≥ 0 a time-dependent Gibbs distribution if and only if the rates ψ(i, j) of single coagulations are of the form ψ(i; j) = if(j) + jf(i), where f is an arbitrary nonnegative function on the set of positive integers. We also obtain a recurrence relation for weights of these Gibbs distributions that allow us to derive the general form of the solution and the explicit solutions in three particular cases of the function f. For the three corresponding models, we study the probability of coagulation into one giant cluster by time t > 0.

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12

Granovsky, Boris L., and Alexander V. Kryvoshaev. "Coagulation Processes with Gibbsian Time Evolution." Journal of Applied Probability 49, no. 03 (September 2012): 612–26. http://dx.doi.org/10.1017/s0021900200009414.

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We prove that a stochastic process of pure coagulation has at any timet≥ 0 a time-dependent Gibbs distribution if and only if the rates ψ(i,j) of single coagulations are of the form ψ(i;j) =if(j) +jf(i), wherefis an arbitrary nonnegative function on the set of positive integers. We also obtain a recurrence relation for weights of these Gibbs distributions that allow us to derive the general form of the solution and the explicit solutions in three particular cases of the functionf. For the three corresponding models, we study the probability of coagulation into one giant cluster by timet> 0.

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13

Maslov, Artem, and Marta Mashevska. "BLOOD COAGULATION MONITORING SYSTEM." Measuring Equipment and Metrology 81, no. 3 (2020): 24–27. http://dx.doi.org/10.23939/istcmtm2020.03.024.

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14

Chee, YL. "Coagulation." Journal of the Royal College of Physicians of Edinburgh 44, no. 1 (2014): 42–45. http://dx.doi.org/10.4997/jrcpe.2014.110.

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15

Aird, William C. "Coagulation." Critical Care Medicine 33, Suppl (December 2005): S485—S487. http://dx.doi.org/10.1097/01.ccm.0000186267.66402.24.

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16

Rubin, Peter C. "Coagulation." Current Obstetrics & Gynaecology 1, no. 4 (December 1991): 185. http://dx.doi.org/10.1016/0957-5847(91)90044-x.

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17

Albanese, Alessio, Antonio Tuttolomondo, Carmelo Anile, Giovanni Sabatino, Angelo Pompucci, Antonio Pinto, Guiseppe Licata, and Annunziato Mangiola. "Spontaneous chronic subdural hematomas in young adults with a deficiency of coagulation factor XIII." Journal of Neurosurgery 102, no. 6 (June 2005): 1130–32. http://dx.doi.org/10.3171/jns.2005.102.6.1130.

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✓ Chronic subdural hematomas (SDHs) generally occur in elderly patients. Its pathogenesis is usually related to head trauma with tearing and rupture of the bridging veins, although in some cases a history of trauma is not recognizable. There are many reports regarding the association between spontaneous chronic SDHs and an alteration in coagulative parameters. A coagulative disorder should be suspected when an unexplained hemorrhage occurs, especially in a young patient. The authors report on three young men with a deficiency in coagulation factor XIII (FXIII) who underwent surgery for chronic SDHs. The role of FXIII in the pathogenesis of chronic SDH is emphasized. In patients with unexplained chronic SDH all coagulation parameters and factors should be screened to identify an eventual coagulative disorder.

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18

Dempfle, Carl-Erik. "Disseminated intravascular coagulation and coagulation disorders." Current Opinion in Anaesthesiology 17, no. 2 (April 2004): 125–29. http://dx.doi.org/10.1097/00001503-200404000-00006.

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19

Bailleul, I. F. "Spatial coagulation with bounded coagulation rate." Journal of Evolution Equations 11, no. 3 (March 9, 2011): 675–86. http://dx.doi.org/10.1007/s00028-011-0105-3.

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20

Mercer, Paul F., and Rachel C. Chambers. "Coagulation and coagulation signalling in fibrosis." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832, no. 7 (July 2013): 1018–27. http://dx.doi.org/10.1016/j.bbadis.2012.12.013.

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21

Islam, MA, S. Sultana, MSI Sojib, MSR Siddiki, MF Rahman, MA Mannan, R. Jahan, and MS Bari. "Chemical and microbial quality of whey from cow milk using calf rennet, microbial rennet, lactic acid and papaya latex." Bangladesh Journal of Animal Science 50, no. 2 (February 8, 2022): 107–13. http://dx.doi.org/10.3329/bjas.v50i2.58138.

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The purpose of the study was to determine the quality of whey obtained from cow milk using different types of coagulants (microbial rennet, calf rennet, lactic acid and papaya latex). The quality of whey was evaluated with the help of chemical and microbial tests. Results revealed that maximum whey yield (765 mL/L milk) was obtained from lactic acid coagulation which was 17 mL higher than that of the microbial rennet coagulation (p=0.000). The pH was found significantly (p<0.05) higher when the microbial rennet was used as coagulants. Whey obtained by the lactic acid coagulation was superior in terms of chemical quality compared to the whey obtained by coagulating action of other coagulating agents (p=0.000-0.001). Total solids and lactose content was found highest (7.2% and 4.8%, respectively) in lactic acid whey which was significantly higher (≈1%) than that of the other types of whey (p=0.000). In addition, protein content was also found higher (p<0.05) in whey obtained by lactic coagulation. On the other hand, efficiency of fat and ash recovery in curd was found lowest in calf rennet (p=0.000) among the studied coagulants. However, phosphorus content was highest (p=0.005) in calf rennet whey and the whey obtained by microbial rennet coagulation had the lowest (p=0.000) calcium concentration. Microbial load was found maximum (117 cfu × 104/mL) in whey drained out in microbial rennet coagulation, whereas, papaya latex whey had the lowest count (78 cfu × 104/ml), and the microbial count of other two whey was intermediate of them (p=0.000-0.001). In general, considering all the quality attributes, lactic acid whey was found better followed by calf rennet and papaya latex. It indicates more nutrient recovery in the curd produced by the microbial rennet. Bang. J. Anim. Sci. 2021. 50 (2): 107-113

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22

Johnson, K., L. Aarden, Y. Choi, E. De Groot, and A. Creasey. "The proinflammatory cytokine response to coagulation and endotoxin in whole blood." Blood 87, no. 12 (June 15, 1996): 5051–60. http://dx.doi.org/10.1182/blood.v87.12.5051.bloodjournal87125051.

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Acute inflammatory illnesses, including the sepsis syndrome, often include a component of coagulation. A human whole blood culture system was developed so that the relationship between coagulation activation and cytokine responses in the presence or absence of lipopolysaccharide (LPS) could be evaluated. In the absence of LPS stimulation, coagulation activation resulted in a novel pattern of cytokine production. During a 4-hour culture of coagulating blood, significant production of interleukin-8 (IL-8; >2,000 pg/mL) was observed, whereas other proinflammatory cytokines including IL-1 beta, IL-6, or tumor necrosis factor a were undetectable or less than 35 pg/mL. The cytokine profile was distinct from that of fully anticoagulated, LPS-stimulated blood, which showed levels of all the indicated proinflammatory cytokines > or = 2,000 pg/mL over the same time period. Over 24 to 48 hours, the coagulation-induced cytokine response was characterized by marked and sustained IL-8 production, limited IL-6 generation (with kinetics delayed relative to IL-8), and minimal or undetectable tumor necrosis factor alpha levels. The magnitude of the whole blood IL-8 response correlated with the level of coagulation activation as determined by measurement of thrombin-antithrombin III complex formation. The combined stimuli of coagulation activation and LPS challenge induced a synergistic enhancement of IL-8 production but not of IL-6. Coagulation-induced cytokine production and the synergistic production of IL-8 by coagulation and LPS could be attenuated by hirudin or tissue factor pathway inhibitor (TFPI). Studies to elucidate mechanisms implicated (1) the TFPI third Kunitz and carboxy-terminus as important structural components for TFPI regulation of coagulation activation and (2) thrombin as a candidate mediator of the mononuclear cell cytokine response to coagulation activation. In summary, a unique aspect of the crosstalk between the coagulation and cytokine cascades in whole blood is shown with the identification of IL-8 as a key proinflammatory participant.

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23

Malacarne, Massimo, Piero Franceschi, Paolo Formaggioni, Sandro Sandri, Primo Mariani, and Andrea Summer. "Influence of micellar calcium and phosphorus on rennet coagulation properties of cows milk." Journal of Dairy Research 81, no. 2 (December 17, 2013): 129–36. http://dx.doi.org/10.1017/s0022029913000630.

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The main requirement for milk processed in most cheese typologies is its rennet coagulation ability. Despite the increasing number of studies, the causes for abnormal coagulation of milk are not fully understood. The aim of this study was to ascertain relationships between milk characteristics and its rennet coagulation ability, focusing on the influence of calcium (Ca) and phosphorus (P). Ca and P are essential constituents of the micelles. Micellar P can be present as part of colloidal calcium phosphate (inorganic-P) or covalently bound to caseins as phosphate groups (casein-P). Eighty one herd milk samples (SCC<400 000 cell/ml) were classified as Optimal (8), Suboptimal (39) Poor (29) and Non-coagulating milk (5), according to their rennet coagulation parameters as assessed by lactodynamographic test. Samples were analysed for their chemical composition (basic composition, protein fractions, minerals and salt equilibria), physicochemical parameters (pH and titratable acidity) and rheological properties. Optimal milk was characterised by the highest contents of major constituents, protein fractions and minerals, lowest content of chloride and highest values of titratable acidity. Non-coagulating milk was characterised by the highest values of pH and the lowest of titratable acidity. At micellar level, Optimal milk showed the highest values of colloidal Ca, casein-P and colloidal Mg (g/100 g casein), while Non-coagulating milk showed the lowest values. Interestingly, there was no statistical difference regarding the content of colloidal inorganic-P (g/100 g casein) between Optimal and Non-coagulating milks. Overall, high mineralisation of the micelle (expressed as g inorganic-P/100 g casein) positively affect its rennetability. However, excessive mineralisation could lead to a reduction of the phosphate groups (g casein-P/100 g casein) available for curd formation.

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24

Dwarakanath, H., P. Gurumoorthi, K. Jayaraj Rao, and C. N. Pagote. "Studies on Alum as Milk Coagulating Agent in the Manufacture of Paneer – An Indian Cottage Cheese." Journal of Food Engineering and Technology 9, no. 2 (December 15, 2020): 64–72. http://dx.doi.org/10.32732/jfet.2020.9.2.64.

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Alum is a white crystalline double sulphate of aluminum and potassium that is commonly used as an astringent. Utilising its protein binding property, alum was studied as coagulating agent of milk in the preparation of paneer. Paneer is a soft variety of cottage cheese very popular in Indian sub-continent, used in various culinary dishes. Its preparation essentially involves acid coagulation of hot milk and pressing of the hot coagulum to form a compact block which is then cooled by immersing in chilled water. Citric acid and vinegar are commonly used as coagulating agents of milk during paneer manufacture. However, when alum was used as a coagulating agent, it was observed that most of the proteins were amalgamated during coagulation process resulting in enhanced yield of paneer. It also resulted in reduced solids losses in whey. However, use of alum resulted in a slight astringency in paneer, hence it was recommended to be used in combination with common coagulant i.e. citric acid. The solids content (losses) in whey were 6.62, 6.08, and 6.32 %, respectively for citric acid, alum and citric acid + alum mixture used as coagulating agents. Similarly, the yields of paneer were 16.42, 19.04 and 16.99 %. The alum coagulated paneer looked glossy and attractive which was indicated by reflectance values of 83.75% as against 79% for control paneer sample. The paneer made by alum coagulation had slightly brittle texture.

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25

Kim, Byung-Wook. "Pathologic validation of ablation therapy for gastric epithelial neoplasia: comparison of argon plasma coagulations vs. coagulation forceps." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 82. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.82.

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82 Background: Ablation therapy has been introduced as an alternative in the management of gastric epithelial neoplasia. However, most of previous studies were retrospective observational studies and has not been validated pathologically. The aim of this study was to validate the effect of ablation therapy for gastric epithelial neoplasia pathologically. Methods: After ablation therapy either by argon plasma coagulations (APC) or by coagulation forceps for gastric epithelial neoplasia, immediate endoscopic resection for the lesions was performed. Consequent histologic mappings for the lesions were followed for the residual tumors. Factors which can affect the residual tumors were analyzed. Results: Twenty nine patients among 33 patients who underwent APC (87.9%) and 21 patients among 26 patients who underwent coagulation forceps (80.8%) showed residual tumors. Factors such as type of coagulation therapy, size of the lesion, type of the lesion (elevated vs. flat) and coagulation time/cm2 of the lesion were not associated with complete removal of the lesions. Conclusions: Ablation therapy is inadequate for complete removal of gastric epithelial neoplasia and this therapy cannot replace endoscopic resection. Clinical trial information: KCT0001587.

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Kasireddy, Nithya, Elizabeth M. Cummins, Huy Q. Pham, Amina Rafique, and Damir B. Khismatullin. "Small-Volume Noncontact Assessment of Blood Coagulation Via Acoustic Tweezing Coagulometry." Blood 138, Supplement 1 (November 5, 2021): 3178. http://dx.doi.org/10.1182/blood-2021-153819.

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Abstract Introduction: Blood coagulation analysis is routinely performed to assess bleeding and thrombotic risks in surgical and critical care patients as well as in patients with diseases that cause coagulation abnormalities (e.g., hemophilia, thrombophilia and sickle cell disease). Majority of coagulation assays are based on photo-optical measurement of coagulation onset in blood plasma such as prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) and viscoelastic measurement of coagulating whole blood, often referred to as "global coagulation analysis", mostly done by thromboelastography (TEG, ROTEM) but they require large sample volume (> 0.5ml) requiring venipuncture, have poor standardization, and are unreliable tools to predict bleeding/thrombotic risk. Acoustic tweezing coagulometry (ATC) is an innovative noncontact drop-of-blood coagulation analysis technique that can perform both photo-optical and viscoelastic coagulation analysis with a sample volume as low as 4 μl to provide a comprehensive set of clinically relevant coagulation parameters such as blood viscosity, elasticity, reaction time, clotting rate, maximum clot stiffness, fibrin formation rate and cross-linking kinetics helpful for diagnosis and prediction of bleeding and thrombotic risks. ATC is particularly valuable for the pediatric patients as it enables safe and reliable point of care coagulation assessment with minimal sample volume. Materials and Methods: In this project, we demonstrate the feasibility of ATC for coagulation analysis by validation and standardization of the technique using whole blood collected from healthy adult volunteers and commercially purchased blood plasma. Further, we present the ability of ATC to assess bleeding risk in commercial blood plasma with coagulation FVIII deficiency with and without inhibitors, as well as whole blood collected from pediatric Hemophilia A patients without inhibitors. The time dependent changes in elasticity (elastic tweezograph, Figure 1A) and viscosity (viscous tweezograph, Figure 1B) of coagulating blood plasma or whole blood sample are used to extract the following coagulation parameters: clot initiation time (CIT), clotting rate (CR), clotting time (CT), time to firm clot formation (TFCF), and maximum clot stiffness (MCS) from elastic tweezograph; reaction time (RT), fibrin formation rate (FFR), and maximum fibrin level (MFL) from viscous tweezograph. Results and Discussion: Figure 1C shows the elastic tweezograph and figure 1D shows the viscous tweezograph of the healthy plasma, plasma with coagulation FVIII deficieny and plasma with inhibitors for coagulation FVIII activated via the intrinsic pathway of coagulation. The tweezographs suggest that the clot initiation is faster in healthy plasma compared to the FVIII deficient plasma and FVIII inhibitor plasma. The clotting rate is highest for healthy plasma followed by the FVIII deficient plasma and is the lowest for the plasma with FVIII inhibitors suggesting a delayed clot formation in the deficient and inhibitor groups. They all reach a similar final clot stiffness, but the time to firm clot formation is least in healthy plasma as expected and increases in the FVIII deficient group and further increases in the FVIII inhibitor group. Conclusions: Acoustic tweezing coagulometry can successfully measure the viscosity, elasticity and coagulation of whole blood and blood plasma with only a drop of the sample. This technique can successfully assess the bleeding risks in pediatric and adult patients with Hemophilia. Acknowledgements: This study has been supported by American Heart Association pre doctoral fellowship 20PRE35210991, U.S. National Science Foundation grant 1438537, American Heart Association Grant-in-Aid 13GRNT17200013, and Tulane University intramural grants. The acoustic tweezing technology is protected by pending patents PCT/US14/55559, PCT/US2018/014879 and PCT/US21/15336. Figure 1 Figure 1. Disclosures Kasireddy: Levisonics Inc.: Current Employment. Rafique: Pfizer Inc.: Consultancy; CSL Behring: Consultancy; HEMA Biologics: Consultancy. Khismatullin: Levisonics Inc.: Current equity holder in publicly-traded company; Levisonics Inc.: Patents & Royalties: PCT/US14/55559 (pending); Levisonics Inc.: Patents & Royalties: PCT/US2018/014879 (issued) ; Levisonics Inc.: Patents & Royalties: PCT/US21/15336 (pending)..

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27

Guth, Jo Ladley, and David Blomberg. "Disseminated Intravascular Coagulation and Coagulation Related Syndromes,." Critical Care Medicine 13, no. 10 (October 1985): 876. http://dx.doi.org/10.1097/00003246-198510000-00035.

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Posma, J. J. N., J. J. Posthuma, and H. M. H. Spronk. "Coagulation and non-coagulation effects of thrombin." Journal of Thrombosis and Haemostasis 14, no. 10 (October 2016): 1908–16. http://dx.doi.org/10.1111/jth.13441.

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29

Ellasson, B., W. Egli, J. R. Ferguson, and H. Jodeit. "Coagulation of bipolarly charged aerosols in a stack coagulator." Journal of Aerosol Science 18, no. 6 (December 1987): 869–72. http://dx.doi.org/10.1016/0021-8502(87)90143-1.

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Nieuwenhuys, Cécile M., Marion A. Feijge, Suzette Béguin, and Johan W. Heemskerk. "Monitoring Hypocoagulant Conditions in Rat Plasma: Factors Determining the Endogenous Thrombin Potential of Tissue Factor-Activated Plasma." Thrombosis and Haemostasis 84, no. 12 (2000): 1045–51. http://dx.doi.org/10.1055/s-0037-1614169.

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SummaryAutomated human plasma, continuous monitoring of the formation and inactivation of thrombin during the coagulation process provides an adequate way to detect hypo- and hypercoagulant conditions. Here, we describe an analogous procedure to determine the endogenous thrombin potential (ETP), i. e. the free thrombin concentration-time integral, of coagulating rat plasma. When activated with tissue factor, the ETP of plasma from Wistar rats was comparable to the ETP of human plasma, in spite of a relatively short half-life time of free thrombin in rat plasma. The ETP was highly sensitive to heparin as well as to administration of vitamin K antagonist or feeding of the animals with a vitamin K-deficient diet. In plasma that was activated under sub-optimal conditions (reduced levels of tissue factor or vitamin K-dependent coagulation factors), the ETP increased with the rate of thrombin formation in the first minutes of the coagulation process. Since both parameters are dependent of the prothrombin concentration, it appears that this level plays an important role in determining both the initial and total activity of the coagulation system. Thus, automated measurement of free thrombin during the coagulation process of rat plasma allows a detailed analysis of hypocoagulability in this animal model.

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Skvortsov, Ivan Y., Valery G. Kulichikhin, Igor I. Ponomarev, Lydia A. Varfolomeeva, Mikhail S. Kuzin, Dmitry Y. Razorenov, and Kirill M. Skupov. "Some Specifics of Defect-Free Poly-(o-aminophenylene)naphthoylenimide Fibers Preparation by Wet Spinning." Materials 15, no. 3 (January 21, 2022): 808. http://dx.doi.org/10.3390/ma15030808.

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A series of model experiments were carried out on drops of poly-(o-aminophenylene)naphthoylenimide (PANI-O) solutions in N-methyl-2-pyrrolidone (NMP) surrounded by a coagulant of different compositions as starting points of defect-free fibers spinning by the wet method. An influence of compositions of dopes and multicomponent coagulants on the diffusion kinetics and drop morphology during coagulation has been investigated. It is shown that the defining parameters of the coagulation process are viscoelastic properties of the polymer solution and the diffusion activity of the coagulant, meaning not only the rate of coagulation but also the presence/absence of macro defects in the resulting fiber. The optimal morphology of as-spun fibers is obtained by coagulation of solution in a three-component mixture containing solvent and two precipitants of different activity (water and ethanol). The chosen coagulating mixture was used for the fiber spinning of PANI-O with different molecular weights dopes, and fibers with sufficiently high strength (~250 MPa), moduli (~2.1 MPa), and elongation at break (50%) were obtained.

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Liu, Liqi, Lei Chen, Zuming Hu, Junrong Yu, Jing-Zhu, Jinliang Sun, and Musu Ren. "Fabrication of the Colored PMIA Fibers by Wet Spinning: Effect of Spinning Parameters on the Coagulation Process." Journal of Engineered Fibers and Fabrics 9, no. 1 (March 2014): 155892501400900. http://dx.doi.org/10.1177/155892501400900116.

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The poly (m-phenylene isophthalamide) (PMIA) fiber, which can be prepared by wet spinning, is a kind of aromatic polyamide fiber. The spinning parameters could influence the performance and structure of the colored PMIA fiber such as the diffusion coefficient and coagulation bath. In this study, the PMIA spinning solutions doped with Color Inde purple 120 were first commixed in a pressurizer and then spun into a coagulation bath under a pressure about 0.3 MPa. In the coagulation bath, the pure or dope-dyed PMIA fibers were prepared by wet spinning at 323 K, and then the as-spun fibers were extracted by an ultrasonic oscillation method. The effects of jet stretch ratio, temperature, and concentration of the coagulation bath on the ratio of diffusion coefficient of solvent to coagulator were analyzed during the spinning process of dope-dyed PMIA fibers. The properties and structures of the colored PMIA fibers were characterized by SEM. Finally the most optimized spinning technology of the dope-dyed PMIA fiber was obtained and the dope-dyed PMIA fibers were successfully fabricated through wet spinning.

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B.D, Manjunath, Abhishek G., and Prem Kumar A. "Coagulation Abnormalities in Breast Cancer." New Indian Journal of Surgery 9, no. 2 (2018): 218–23. http://dx.doi.org/10.21088/nijs.0976.4747.9218.20.

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34

Tejera, Javier, Daphne Hermosilla, Antonio Gascó, Carlos Negro, and Ángeles Blanco. "Combining Coagulation and Electrocoagulation with UVA-LED Photo-Fenton to Improve the Efficiency and Reduce the Cost of Mature Landfill Leachate Treatment." Molecules 26, no. 21 (October 25, 2021): 6425. http://dx.doi.org/10.3390/molecules26216425.

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This study focused on the reduction of the treatment cost of mature landfill leachate (LL) by enhancing the coagulation pre-treatment before a UVA-LED photo-Fenton process. A more efficient advanced coagulation pretreatment was designed by combining conventional coagulation (CC) and electro-coagulation (EC). Regardless of the order in which the two coagulations were applied, the combination achieved more than 73% color removal, 80% COD removal, and 27% SUVA removal. However, the coagulation order had a great influence on both final pH and total dissolved iron, which were key parameters for the UVA-LED photo-Fenton post-treatment. CC (pH = 5; 2 g L−1 of FeCl36H2O) followed by EC (pH = 5; 10 mA cm−2) resulted in a pH of 6.4 and 100 mg L−1 of dissolved iron, whereas EC (pH = 4; 10 mA cm−2) followed by CC (pH = 6; 1 g L−1 FeCl36H2O) led to a final pH of 3.4 and 210 mg L−1 dissolved iron. This last combination was therefore considered better for the posterior photo-Fenton treatment. Results at the best cost-efficient [H2O2]:COD ratio of 1.063 showed a high treatment efficiency, namely the removal of 99% of the color, 89% of the COD, and 60% of the SUVA. Conductivity was reduced by 17%, and biodegradability increased to BOD5:COD = 0.40. With this proposed treatment, a final COD of only 453 mg O2 L−1 was obtained at a treatment cost of EUR 3.42 kg COD−1.

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35

Tyrisevä, Anna-Maria, Tiina Ikonen, and Matti Ojala. "Repeatability estimates for milk coagulation traits and non-coagulation of milk in Finnish Ayrshire cows." Journal of Dairy Research 70, no. 1 (February 2003): 91–98. http://dx.doi.org/10.1017/s0022029902005939.

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Effects of systematic environmental factors and milk production and quality traits on milk coagulation properties (MCP), and on repeatability of those traits were estimated from 979 milk samples collected once a month over a period of 2 years from 83 Finnish Ayrshire cows. Estimation was based on a multitrait animal model and REML methodology. In addition, persistence of non-coagulation of milk in individual cows, and factors associated with it were established from a sub sample of 24 cows producing non-coagulating (NC) milk at least once. MCP were at their best during the first lactation, at the beginning and at the end of lactation, and during grazing seasons. Variation in MCP with systematic environmental factors was partly due to variation in composition and quality of milk, especially in pH and ln (somatic cell count, SCC). Coefficients of repeatability for milk coagulation time and curd firmness were 0·65 and 0·68. These estimates were of the same magnitude as those for protein content, but were higher than those for daily milk yield, fat content, pH, and SCC. Based on the repeatability estimates for the milk coagulation traits and effects of the environmental factors, cows should be sampled at least three times during a lactation to estimate reliably breeding values for the milk coagulation traits. A total of 10% of the milk samples did not coagulate in 30 min after addition of rennet. Cows that produced NC milk at least once (30% of the cows) could be classified into those that produced NC milk only a few times during a lactation and those that produced NC milk at almost every sampling. Based on logistic regression analyses, peak and mid-lactation, high milk yield, low protein and fat content and high pH increased the risk of non-coagulation of milk.

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Journeycake, J. M., and G. R. Buchanan. "Coagulation Disorders." Pediatrics in Review 24, no. 3 (March 1, 2003): 83–91. http://dx.doi.org/10.1542/pir.24-3-83.

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Journeycake, Janna M., and George R. Buchanan. "Coagulation Disorders." Pediatrics In Review 24, no. 3 (March 1, 2003): 83–91. http://dx.doi.org/10.1542/pir.24.3.83.

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38

Weather, Leonard. "LEIOMYOMA COAGULATION." Southern Medical Journal 88 (October 1995): S49. http://dx.doi.org/10.1097/00007611-199510001-00094.

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39

Wong, Cynthia A. "Coagulation testing." Current Opinion in Anaesthesiology 9, no. 6 (December 1996): 495–98. http://dx.doi.org/10.1097/00001503-199609060-00009.

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Wong, Cynthia A. "Coagulation testing." Current Opinion in Anaesthesiology 9, no. 6 (December 1996): 495–98. http://dx.doi.org/10.1097/00001503-199612000-00009.

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41

GREEN, David. "Coagulation cascade." Hemodialysis International 10, S2 (October 2006): S2—S4. http://dx.doi.org/10.1111/j.1542-4758.2006.00119.x.

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42

Manco-Johnson, Marilyn J. "Coagulation disorders." Current Opinion in Pediatrics 4, no. 1 (February 1992): 102–7. http://dx.doi.org/10.1097/00008480-199202000-00016.

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43

Chokshi, Arati, A. G. G. M. Tielens, and D. Hollenbach. "Dust coagulation." Astrophysical Journal 407 (April 1993): 806. http://dx.doi.org/10.1086/172562.

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Scharf, R. E. "Coagulation disorders." Hämostaseologie 35, no. 04 (2015): 301–2. http://dx.doi.org/10.1055/s-0037-1619820.

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Mann, Kenneth G. "Blood Coagulation." Alcoholism: Clinical and Experimental Research 23, no. 6 (June 1999): 1111–13. http://dx.doi.org/10.1111/j.1530-0277.1999.tb04233.x.

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Grottke, Oliver. "Coagulation management." Current Opinion in Critical Care 18, no. 6 (December 2012): 641–46. http://dx.doi.org/10.1097/mcc.0b013e328358e254.

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Robinson, David, Jonathan L. Parmet, and Jan Charles Horrow. "Coagulation emergencies." Seminars in Anesthesia, Perioperative Medicine and Pain 17, no. 2 (June 1998): 111–20. http://dx.doi.org/10.1016/s0277-0326(98)80034-2.

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Norris, Lucy A. "Blood coagulation." Best Practice & Research Clinical Obstetrics & Gynaecology 17, no. 3 (June 2003): 369–83. http://dx.doi.org/10.1016/s1521-6934(03)00014-2.

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Norris, J. R. "Cluster Coagulation." Communications in Mathematical Physics 209, no. 2 (February 1, 2000): 407–35. http://dx.doi.org/10.1007/s002200050026.

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Soliman, Doreen E., and Lynn M. Broadman. "Coagulation Defects." Anesthesiology Clinics of North America 24, no. 3 (September 2006): 549–78. http://dx.doi.org/10.1016/j.atc.2006.05.009.

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