Journal articles: 'Co 191'

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Kang, Peng-Cheng, Kai-Ming Leng, Yue-Ping Liu, Yang Liu, Yi Xu, Wei Qin, Jian-Jun Gao, et al. "miR-191 Inhibition Induces Apoptosis Through Reactivating Secreted Frizzled-Related Protein-1 in Cholangiocarcinoma." Cellular Physiology and Biochemistry 49, no. 5 (2018): 1933–42. http://dx.doi.org/10.1159/000493654.

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Background/Aims: Cholangiocarcinoma (CCA) is one of the most common malignant tumors of the biliary tract originating from biliary epithelial cells. Although many therapeutic strategies have been developed to treat CCA, the survival rate for CCA patients is still quite low. Thus it is urgent to elucidate the pathogenesis of CCA and to explore novel therapeutic targets. miR-191 has been shown to be associated with many human solid cancers, but the function of miR-191 in CCA is still poorly understood. Methods: We first investigated the expression level of miR-191 in human CCA tissues and cell lines with quantitative real-time PCR (qRT-PCR). The effects of miR-191 on CCA cells were determined by Cell Counting Kit-8 assay, colony formation assay and acridine orange/ethidium bromide staining. Finally, we utilized qRT-PCR, western blot and luciferase reporter assays to verify the miR-191 target gene. Results: We showed that miR-191 was up-regulated in CCA cell lines and patients. Knockdown of miR-191 by transfection of its inhibitor sequence blocked RBE cells viability and induced apoptosis of RBE cells. Both qRT-PCR and western blot analysis showed that the secreted frizzled-related protein-1 (sFRP1) level was negatively correlated with that of miR-191. Luciferase assay validated that sFRP1 was a direct target of miR-191. Moreover, knockdown of miR-191 led to suppression of Wnt/β-catenin signaling activation. Co-transfection of sFRP1 small interfering RNA (siRNA) and miR-191 inhibitor re-activated the Wnt/β-catenin signaling pathway as detected by an increased level of β-catenin and phosphorylation of GSK-3β, and restored the expression of survivin and c-myc in RBE cells. Co-transfection of sFRP1 siRNA with miR-191 inhibitor restored the colony formation ability and viability of RBE cells. Conclusion: Taken together, our results demonstrate a novel insight into miR-191 biological function in CCA. Our findings suggest that miR-191 is a potential therapeutic target of CCA treatment.

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Fukumi, Kohei, Akiyoshi Chayahara, Kohei Kadono, Hiroyuki Kageyama, Tomoko Akai, Hiroshi Mizoguchi, Naoyuki Kitamura, Masaki Makihara, Yuji Horino, and Kanenaga Fujii. "Coordination structures of implanted Fe, Co, and Ni ions in silica glass by x-ray absorption fine structure spectroscopy." Journal of Materials Research 16, no. 1 (January 2001): 155–62. http://dx.doi.org/10.1557/jmr.2001.0026.

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Coordination structures of implanted Fe, Co, and Ni ions were studied in 1.78–2.00-MeV 5 × 1016 ions/cm2-implanted silica glasses by x-ray absorption and optical absorption spectroscopies. It was found from x-ray absorption spectra that the implanted Fe, Co, and Ni ions are coordinated by ca.3 oxygen atoms. The implanted ions dispersed in glass matrix and did not form crystals. The valence of the implanted ions was about 1.5. The Fe–O, Co–O, and Ni–O interatomic distances were 190, 191, and 192 pm, respectively. In addition, it was found from optical absorption spectra that one-fifth of implanted Co ions were present as Co2+ ions in tetrahedral symmetry.

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Dabrowski, I., M. Vervloet, and D. C. Wang. "The c3Π – b3Σ+ transition of CO near 8245 cm−1." Canadian Journal of Physics 65, no. 9 (September 1, 1987): 1171–77. http://dx.doi.org/10.1139/p87-191.

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A transition between two high-lying electronic states of CO, c3Π – b3Σ+, has been observed by high resolution Fourier transform spectroscopy, in the near infrared, around 8245 cm−1. The triplet splittings of both c3Π and b3Σ+ have clearly been observed. The value A = 1.504(12) cm−1 has been determined for c3Π and confirms the previous direct determination of Klopotek and Vidal (J. Opt. Soc. Am. B, 2, 869 (1985)). Because these states were found to be heavily perturbed, only the analysis and effective rotational constants are reported.

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Serikbayev, Bazarbay, Duisek Kamysbayev, Z. Tilepbergen, O. Ahmet, and Zhalgas Uteuliev. "Electro-catalytic properties of tri-(Fe, Co and Ni) shungite composites." Chemical Bulletin of Kazakh National University, no. 1 (March 31, 2012): 187. http://dx.doi.org/10.15328/chemb_2012_1187-191.

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Mertes, Bernardo, Nadine Kuniss, Michael Piorkowski, Linus Paul Mertes, and Hans-Peter Hammes. "Screening Results for Diabetic Retinopathy in Germany in a Real-world Cohort in a Metropolitan Diabetes Care Center." Experimental and Clinical Endocrinology & Diabetes 131, no. 04 (April 2023): 182–86. http://dx.doi.org/10.1055/a-2002-5116.

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Abstract Background Retinal screening is mandatory to prevent vision loss and blindness due to diabetic retinopathy (DR). The aim of the study was to determine retinopathy screening rates and potential barriers in a German metropolitan diabetes care center. Methods Between May and October 2019, 265 patients with diabetes mellitus (95% type 2 diabetes; age 62±13.2 years; diabetes duration 11.1±8.5 years, HbA1c 7.4±1.0%) were referred to an ophthalmologist (referral form with order “Fundoscopy in diabetes mellitus, findings requested,” completed documentation form “General practitioner’s/diabetologist’s report to the ophthalmologist” and prepared documentation form “Ophthalmologist’s report”). A structured interview was used to assess the level of compliance with the guidelines and to identify potential barriers to retinopathy screening in a real-world setting, including the quantification of extra payments. Results All patients were interviewed at 7.9±2.5 months after the referral for retinopathy screening had been issued. According to patient reporting, fundoscopy was performed in 191 (75%) patients. Ophthalmological reports were obtained from 119/191 (62%) patients (46% of the entire cohort). 10/119 (8%) patients had been previously diagnosed with DR and 6/119 (5%) with new-onset DR. In 158/191 (83%) of patients, the referral had been accepted by the ophthalmology practice, of which 25,1% made a co-payment of 36.2±37.6 €. Discussion Despite a high screening performance in a real-world setting, complete screening in compliance with German guidelines, including written reporting, was found in less than half of the cohort. The prevalence and incidence of DR are high. Even when referred according to the regulations, one-quarter of patients made a co-payment. Efficient solutions to current barriers can emerge with mutual time-saving information prior to examination and feedback about the implementation of findings into treatment.

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Burn, Carine Layat, Debra Nestel, David Gachoud, and Scott Reeves. "Board 191 - Program Innovations Abstract Simulated Patient as Co-Facilitators." Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare 8, no. 6 (December 2013): 455–56. http://dx.doi.org/10.1097/01.sih.0000441456.58165.96.

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Meijering, Frits. "The new age of innovation. Driving co-created value through global networks." Journal of Social Intervention: Theory and Practice 18, no. 4 (December 8, 2009): 103. http://dx.doi.org/10.18352/jsi.191.

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Filak, Agnieszka. "Charakter prawny służby duchownego w Kościele Ewangelicko-Augsburskim w Rzeczypospolitej Polskiej." Studia z Prawa Wyznaniowego 21 (December 18, 2018): 141–55. http://dx.doi.org/10.31743/spw.191.

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Przedmiot niniejszego opracowania stanowi przedstawienie charakteru prawnego służby duchownego – diakona, wikariusza i proboszcza – w Kościele Ewangelicko-Augsburskim w RP. Autorka świadomie rezygnuje z analizy statusu prawnego służby biskupa, jako że biskupi diecezjalni zasadniczo pełnią również funkcję proboszcza, co w istotnym stopniu przesądza o ich sytuacji formalnej. Podstawę analizy sytuacji prawnej służby duchownych stanowią akty prawa kościelnego, w tym przede wszystkim Zasadnicze Prawo Wewnętrzne oraz Pragmatyka Służbowa. Urząd duchownego w Kościele Ewangelicko-Augsburskim pochodzi z ustanowienia Bożego, ale ma również swój wymiar prawny określony w Zasadniczym Prawie Wewnętrznym. Kościół luterański uznaje jeden urząd duchowny, który posiada trzy posługi: biskupa, prezbitera i diakona. Urząd kościelny nie jest hierarchiczny i każda z posług urzędu kościelnego jest sobie równa, chociaż różnią się od siebie zakresem obowiązków. Tym, co zespala posługi urzędu kościelnego, jest wspólne prawo do sprawowania władzy kluczy, a przez to w konsekwencji do odpuszczania i zatrzymywania grzechów, głoszenia Ewangelii i sprawowania sakramentów. Ordynacja nie ma charakteru sakramentalnego. Prawo kościelne określa warunki ordynacji, prawa i obowiązki duchownych, a także zasady powoływania na urząd oraz skreślenia z listy duchownych.

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Chen, Xiang-Sheng, Yue-Ping Yin, Guo-Jun Liang, Xiang-Dong Gong, Hua-Sheng Li, Mei-Qin Shi, and Yan-Hua Yu. "Co-infection with genital gonorrhoea and genital chlamydia in female sex workers in Yunnan, China." International Journal of STD & AIDS 17, no. 5 (May 1, 2006): 329–32. http://dx.doi.org/10.1258/095646206776790088.

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An observational study on prevalence of co-infection with gonorrhoea and chlamydia was conducted among female sex workers (FSWs) in Kunming, China. A total of 505 FSWs participated in the study. All eligible participants gave informed consent. Demographic, behavioural and clinical information of the participants was gathered by direct structured interviews. Tampon swabs were collected to test for Chlamydia trachomatis and Nesseria gonorrhoeae. One-hundred and twenty-four (24.6%) FSWs were co-infected with these two pathogens. Of the 191 FSWs with gonorrhea, 124 (64.9%, 95% confidence interval [CI] = 57.9–71.3%) were co-infected with chlamydia which was significantly higher than the proportion (41.9%, 95% CI = 36.4–47.6%) co-infected with gonorrhoea among 296 FSWs with chlamydia ( P < 0.001). Only 47 of 191 (24.6%) FSWs with gonococcal infection and 28 of 124 (22.6%) with co-infection with gonorrhoea and chlamydia reported vaginal discharge. The results of the study justify the recommendation in the national sexually transmitted disease (STD) guidelines that patients infected with gonorrhoea also be treated routinely with an anti-chlamydial regimen. However, a periodic mass treatment may be considered in some circumstances in STD control programmes to rapidly reduce the infections in this population.

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Kung, Chung-Wei, Yu-Heng Cheng, Chuan-Ming Tseng, Li-Yao Chou, and Kuo-Chuan Ho. "Low-temperature and template-free fabrication of cobalt oxide acicular nanotube arrays and their applications in supercapacitors." Journal of Materials Chemistry A 3, no. 7 (2015): 4042–48. http://dx.doi.org/10.1039/c4ta06811d.

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Layered cobalt carbonate hydroxide (LCCH) acicular nanorod arrays (ANRAs) are converted to Co₃O₄ acicular nanotube arrays (ANTAs) via Kirkendall effect. The Co₃O₄ ANTAs exhibit a specific capacitance of 979 F g⁻¹, which is higher than that of the Co₃O₄ ANRAs (191 F g⁻¹).

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Esslinger, Theodore L. "Recent Literature on Lichens—191*." Bryologist 106, no. 4 (December 2003): 599–617. http://dx.doi.org/10.1639/0007-2745(2003)106[599:rlol]2.0.co;2.

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Bieging, John H., William L. Peters, and Miju Kang. "THE ARIZONA RADIO OBSERVATORY CO MAPPING SURVEY OF GALACTIC MOLECULAR CLOUDS. I. THE W51 REGION IN CO AND 13 CO J = 2-1 EMISSION." Astrophysical Journal Supplement Series 191, no. 2 (November 15, 2010): 232–46. http://dx.doi.org/10.1088/0067-0049/191/2/232.

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Widom, Cathy Spatz, and Helene Raskin White. "Problem behaviours in abused and neglected children grown up: prevalence and co-occurrence of substance abuse, crime and violence." Criminal Behaviour and Mental Health 7, no. 4 (November 1997): 287–310. http://dx.doi.org/10.1002/cbm.191.

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Johnson, R. A., A. M. Anderson, and E. K. Lilly. "CO Modeling in Alaska." Journal of Cold Regions Engineering 3, no. 4 (December 1989): 191–207. http://dx.doi.org/10.1061/(asce)0887-381x(1989)3:4(191).

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Triantafyllidi, Helen, Dimitrios Benas, Konstantina Sioula, Anastasia Fampri, Dionysia Birmpa, and Ignatios Oikonomidis. "TEN-YEAR FOLLOW-UP STUDY REGARDING TREATMENT COMPLIANCE AND CARDIOVASCULAR EVENTS IN YOUNG FIRST-DIAGNOSED AND NEVER-TREATED HYPERTENSIVES OF A HYPERTENSION-EXCELLENCE-CENTER." Journal of Hypertension 42, Suppl 1 (May 2024): e270. http://dx.doi.org/10.1097/01.hjh.0001022272.58607.5e.

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Objective: Early-onset arterial hypertension (AH) is associated with increased risk for cardiovascular (CV) disease if left untreated. Treatment is based on CV risk estimation in each hypertensive. Compliance of each individual in proposed lifestyle changes and medical treatment is paramount. We aimed to investigate compliance in medical treatment and set as primary endpoint of the study the incidence of any CV events[CV death, acute myocardial infarction (AMI), stroke] and all-cause death of a cohort of young first-diagnosed and never-treated hypertensives of a European Society of Hypertension (ESH) Excellence Center. Design and method: We studied 220 young, non-diabetic (<=50 years) first-diagnosed and never-treated hypertensive patients[42±7years,70% males,41% smokers,BMI=29±5,24-h ambulatory blood pressure monitoring (ABPM)=142±10/91±9mmHg,low-density-lipoprotein cholesterol (LDL-C)=133±36mg/dl,49% had >=1 hypertension-mediated-organ-damage (HMOD)] visiting our ESH Excellence Center(2004-2021). All patients were apparently healthy with no co-morbidities. In each patient, the presence of HMOD was evaluated at baseline(aortic stiffness,left ventricular hypertrophy,coronary flow reserve,diastolic dysfunction). The cohort was re-evaluated at 10±4years post-medical treatment initiation regarding compliance as well as study primary endpoint. Results: 191/220 (87%) young hypertensives[at baseline,42±7years,70% males,40% smokers,body mass index (BMI)=29.5,24-h ABPM=142±10/91±9 mmHg,LDL-C=133±36mg/dl,49% had>1 HMOD) participated in the follow-up study while 29 (13%) patients were lost. We found that 17/191 (9%) quit medical treatment. Home or office blood pressure (BP) was confirmed as controlled(<140/90mmHg) in 151/191 (79%) patients. Regarding CV events, 7/191 (4%) hypertensive patients (at baseline,44±4 years,6/7 males,71% smokers,BMI=30±4,24-h ABPM=142±13/89±11mmHg,LDL-C=175±33mg/dl,87% had>1 HMOD) had an AMI at 6±4 years post-treatment initiation while 1/191 (0.5%) patient died due to lung cancer. Hypertensives with CV events differed regarding increased LDL-C at baseline(175±33vs.131±36, p=0.007),more smokers (p=0.04) and HMOD>1 (p=0.02) compared to the rest of the young hypertensives. Conclusions: Compliance regarding medical treatment was sustained in 9/10 young hypertensives during the 10-year follow-up. Just 4% of the population, smokers with increased LDL-C and HMOD>1, suffered an AMI despite compliance in medical antihypertensive treatment. Subsequently, treating AH in young people needs both lifestyle changes (quit smoking) and medical treatment (hypertension plus hyperlipidemia) in order to prevent future CV events.

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Kukolich, S. G., M. A. Roehrig, S. T. Haubrich, and J. C. Shea. "Erratum: Microwave measurements of cobalt and nitrogen quadrupole coupling in Co(CO)3NO [J. Chem. Phys. 94, 191 (1991)]." Journal of Chemical Physics 94, no. 9 (May 1991): 6338. http://dx.doi.org/10.1063/1.460749.

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Lyszkiewicz, Marcin, Jonas Blume, Natalia Zietara, Katrin Witzlau, Jacek Puchalka, Namita Saran, Sandra Duber, Roy Bishnudeo, Siegfried Weiss, and Andreas Krueger. "Regulation of Transcription Factors Foxp1, E2A and Egr-1 By microRNA-191 Constrains B Lymphocyte Development and Suppresses Development of Diffuse Large B Cell Lymphoma." Blood 126, no. 23 (December 3, 2015): 287. http://dx.doi.org/10.1182/blood.v126.23.287.287.

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Abstract Development of B-cells in the bone marrow is a tightly controlled, multi-step process. Whereas its major transcriptional regulators are well characterized, less is known about its post-transcriptional regulation. It has been demonstrated that B cell development critically depends on microRNAs. Yet, the role of individual members still remains to be uncovered. Relatively subtle regulatory effects of miRNAs are well-visible in the pathways which require tight control. Disruption of such a pathway, where the protein function (i.e. transcription factor) highly depends on the gene dosage, is major cause of malignant transformation. We identified transcription factors Foxp1, E2A and Egr1 as direct targets of microRNA miR-191. Reduced expression of these transcription factors through ectopic expression of miR-191 in B-cell progenitors resulted in numerous secondary effects, such as downregulation of Rag1, Rag2, Dntt and Il7r alpha genes. In consequence, we observed impaired immunoglobulin heavy chain rearrangement and limited responsiveness to IL-7 of B cell progenitors resulting in partial developmental arrest and predisposition of immature B-cells to death during negative selection. Finally, we showed that co-overexpression of E2A or FoxP1 and miR-191 restored normal B cell development, supporting the hypothesis that both transcription factors are functionally relevant targets of miR-191. Having established a regulatory cascade comprising miR-191 at the top of hierarchy and the transcription factors Foxp1, E2A and Egr1 as its direct targets we sought to identify a pathophysiological scenario in which this cascade might be explored therapeutically. Given that the most aggressive forms of human diffuse large B cell lymphoma (DLBCL) are FOXP1 dependent, we assessed whether miR-191 was able to limit growth of DLBCL. Of note, in vivo ectopic expression of miR-191 prevented the growth of DLBCL. Consistent with murine data, expression of the three target genes FOXP1, EGR1 and TCF3 (encoding E2A) was decreased upon miR-191 overexpression. Interestingly, treatment with the histone deacetylase inhibitor vorinostat revealed decreased resistance to cell death of DLBCL lines overexpressing miR-191 in vitro. Thus, our data describe a new regulatory pathway, where miR-191 by fine-tuning key B-lineage transcription factors acts as modulator of B-cell development as well as tumor suppressor in B-lineage malignancy. Disclosures No relevant conflicts of interest to declare.

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Lenin, K., and M. R. Mohan. "Ant colony search algorithm for optimal reactive power optimization." Serbian Journal of Electrical Engineering 3, no. 1 (2006): 77–88. http://dx.doi.org/10.2298/sjee0601077l.

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The paper presents an (ACSA) Ant colony search Algorithm for Optimal Reactive Power Optimization and voltage control of power systems. ACSA is a new co-operative agents? approach, which is inspired by the observation of the behavior of real ant colonies on the topic of ant trial formation and foraging methods. Hence, in the ACSA a set of co-operative agents called "Ants" co-operates to find good solution for Reactive Power Optimization problem. The ACSA is applied for optimal reactive power optimization is evaluated on standard IEEE, 30, 57, 191 (practical) test bus system. The proposed approach is tested and compared to genetic algorithm (GA), Adaptive Genetic Algorithm (AGA).

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P, SHANMUGA SUNDARAM, and SREE RANGASWAMY S.R. "HETEROSIS AND INBREEDING IN BLACK GRAM (Vigna mungo)." Madras Agricultural Journal 82, February (1995): 131–34. http://dx.doi.org/10.29321/maj.10.a01147.

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Heterosis (over mid-parental value), inbreeding depression and inbreeding vigour were estimated among twenty hybrids generated from a 5x5 diallel analysis involving Co 4, Co 5, UG 135. UG 191 and T 9 as parents for total dry matter production (TDMP), grain yield, and harvest index. Wide range of heterosis, inbreeding depression and inbreeding vigour was observed among hybrids for all the characters studied. The implications of heterosis, inbreeding depression and breeding vigour on formulating the improvement programme was discussed and the best cross combinations which would throw superior segregants in the subsequent generations were identified.

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Arumugham, Rajamani, Krishnaveni Vellingiri, Wassim Ferose Habeebrakuman, and Kalaikamal Mohan. "A NEW DENOISING APPROACH FOR THE REMOVAL OF IMPULSE NOISE FROM COLOR IMAGES AND VIDEO SEQUENCES." Image Analysis & Stereology 31, no. 3 (November 28, 2012): 185. http://dx.doi.org/10.5566/ias.v31.p185-191.

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In this paper a novel Lone Diagonal Sorting (LDS) algorithm for denoising color images and videos co-rrupted with salt and pepper noise is proposed. The proposed lone diagonal sorting algorithm uses diagonal sorting alone for denoising of impulse noise. The algorithm has been implemented and tested for various color images and video signals and appreciable performance in terms of PSNR, MSE and SSIM is obtained. Our algorithm has been compared with other standard algorithms. A drastic improvement in the computational time has been achieved without compromising much on the visual quality after reconstruction.

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Kamble, B. G., S. B. Sarode, M. B. Akhare, M. D. Patil, and U. G. Gadkar. "Studies on the genotypic co-efficient of variation and phenotypic co-efficient of variation in chickpea (Cicer arientinum L.) germplasm for yield-attributing characters." INTERNATIONAL JOURNAL OF AGRICULTURAL SCIENCES 20, no. 1 (January 15, 2024): 191–95. http://dx.doi.org/10.15740/has/ijas/20.1/191-195.

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The magnitude of the genotypic co-efficient of variation (GCV) and phenotypic co-efficientof variation (PCV) in chickpea germplasm was observed high for characters like seed yield per plant followed by number of pods per plant, 100 seed weight, plant height, number of secondary branches per plant and number of primary branches per plant. The characteristics viz., seed yield per plant showed high GCV and PCV, moderate heritability and high genetic advance as a per cent of the mean. The characters viz. number of pods per plant, 100 seed weight, harvest index, number of secondary branches per plant and plant height recorded a highly positive significant correlation with seed yield at both genotypic and phenotypic levels. This indicates the simultaneous improvement of these characters through the selection of chickpeas.

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Popova, O. V. "A bestiary of hatred: A co-authored monograph." Voprosy literatury, no. 2 (April 12, 2023): 186–91. http://dx.doi.org/10.31425/0042-8795-2023-2-186-191.

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Putri, Athira Novia. "Kontribusi Dukungan Sosial Rekan Kerja terhadap Burnout pada Tenaga Pendidik Selama Masa Pandemi." Syntax Literate ; Jurnal Ilmiah Indonesia 7, no. 2 (February 26, 2022): 2782. http://dx.doi.org/10.36418/syntax-literate.v7i2.6360.

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The renewal of regulations regarding face-to-face procedures in schools has led to high levels of stress for educators because they have to adapt teaching methods to the latest regulations regarding health protocols. In addition, educators also learn to adjust to the surrounding environment. The high level of stress for educators will turn into burnout. One of the factors that can minimize the emergence of burnout is social support. Social support can come from anywhere, one of which is social support from colleagues. This study aims to empirically examine the effect of peer social support on burnout in educators. The data was obtained through the support of the social scale of co-workers and burnout. Respondents of this study found 191 educators consisting of 38 men and 161 women with a mean age of 41.6. The analysis technique used is regression analysis. The results showed that labor support had a significant effect of 3% on burnout. The social support of co-workers has an essential role in explaining burnout behavior in educators. This is due to the colleague's help in lightening the educator's workload that revives the motivation of educators to do their work.

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Muhammad, Saleh, and Dr Abdul Nasir Kiazai. "A Study on Effects of Co-Curricular Activities on Academic Achievements of Public Secondary School Students of Zarghoon Town Quetta." International Research Journal of Education and Innovation 3, no. 1 (March 31, 2022): 318–25. http://dx.doi.org/10.53575/irjei.v3.01.28(22)318-325.

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The study was conducted to examine the effect of Co-Curricular-Activities on Academic-achievement of Secondary School Students in District Quetta. The purpose of this study is find out that how much boys and girls have interest and participation in Co-Curricular-Activities. The study is Exploratory in nature and author used the Pearson Correlation to explore the relation between Co-Curricular-Activities and Academic Achievement. Co-Curricular-Activities is the Independent Variable and Academic-achievement as Dependent Variable of this study. The population of this study is all the Secondary Schools of District Quetta. The researcher selected the sample of 386 (191 Boys and 195 Girls) secondary school students of grade 10th from 10 different secondary schools of Zarghoon Town, Quetta. The author of the study used the Stratified random sampling technique and carried out the Questionnaire Survey method to examine the relationship of Co-Curricular-Activities with Academic-Achievements using the Class 9th annual examination of Balochsitan Board, Quetta. The analysis of the data in this study revealed that boy’s students were more active in Co-Curricular-Activities in secondary level. The Pearson Correlation value indicates that Co-Curricular-Activities has positive link with academics improvement.

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Irwin, Jones. "Authority Through Freedom. On Freire’s Radicalisation of the Authority-Freedom Problem in Education." Espacio, Tiempo y Educación 5, no. 1 (January 1, 2018): 57. http://dx.doi.org/10.14516/ete.191.

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Paulo Freire’s approach to the question of ‘authority and freedom’ in education and teaching (as well as in the political sphere), takes its cue from his early and radical approach to literacy education in Brazil in the 1960s. However, the radical democratic thrust of this educational vision meets very significant political resistance in Brazil and Freire spends 30 years in exile. This essay explores how this Freirean approach needs to be contextualised in the specifically Brazilian context. However, it also explores his original contribution to the wider problematic of authority and freedom in the Philosophy of Education. In Freire, there is a simultaneous critique of traditionalism and progressivism (not dissimilar to Dewey’s in Experience and Education) and this allows Freire to reconceptualise the relation between authority and freedom in education. We explore how Freire’s 1968 text Pedagogy of the Oppressed articulates this understanding very clearly and from a very strong conceptual-philosophical perspective. In the latter part of the essay, we look at how Freire’s later work, in for example Pedagogy of Hope: Reliving Pedagogy of the Oppressed, represents a return to a more experiential analysis of the question of authority and freedom in education. Nonetheless, while recognising the need for a philosophy of education to develop «in a manner in keeping with the times», there is also a very strong continuity between the early and later work in this understanding. In brief, in both his earlier and later work, Freire develops an understanding of an «authority through freedom», a co-dependent relationship between these two variables in pedagogy, as also in political life.

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Liu, Zhenya, Zirui Ren, Lunyi Yan, and Feng Li. "DeepLRR: An Online Webserver for Leucine-Rich-Repeat Containing Protein Characterization Based on Deep Learning." Plants 11, no. 1 (January 4, 2022): 136. http://dx.doi.org/10.3390/plants11010136.

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Members of the leucine-rich repeat (LRR) superfamily play critical roles in multiple biological processes. As the LRR unit sequence is highly variable, accurately predicting the number and location of LRR units in proteins is a highly challenging task in the field of bioinformatics. Existing methods still need to be improved, especially when it comes to similarity-based methods. We introduce our DeepLRR method based on a convolutional neural network (CNN) model and LRR features to predict the number and location of LRR units in proteins. We compared DeepLRR with six existing methods using a dataset containing 572 LRR proteins and it outperformed all of them when it comes to overall F1 score. In addition, DeepLRR has integrated identifying plant disease-resistance proteins (NLR, LRR-RLK, LRR-RLP) and non-canonical domains. With DeepLRR, 223, 191 and 183 LRR-RLK genes in Arabidopsis (Arabidopsis thaliana), rice (Oryza sativa ssp. Japonica) and tomato (Solanum lycopersicum) genomes were re-annotated, respectively. Chromosome mapping and gene cluster analysis revealed that 24.2% (54/223), 29.8% (57/191) and 16.9% (31/183) of LRR-RLK genes formed gene cluster structures in Arabidopsis, rice and tomato, respectively. Finally, we explored the evolutionary relationship and domain composition of LRR-RLK genes in each plant and distributions of known receptor and co-receptor pairs. This provides a new perspective for the identification of potential receptors and co-receptors.

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Ramirez Kuri, Georgette, Thays K. S. Fidelis, and Ayelén Branca. "Cambios y tendencias del capitalismo dependiente latinoamericano en la fase neoimperialista." Reoriente: estudos sobre marxismo, dependência e sistemas-mundo 2, no. 2 (August 19, 2023): 166–91. http://dx.doi.org/10.54833/issn2764-104x.v2i2p167-191.

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RESUMO Com o objetivo de contribuir para a compreensão da realidade social latino-americana na atual fase neoimperialista, retomamos as contribuições de Ruy Mauro Marini sobre o capitalismo dependente e sobre as transformações históricas dos padrões de reprodução do capital. Considerando a relação dialética entre dependência e imperialismo, a co-determinação entre Estado e capital e a crise estrutural capitalista como características do imperialismo, articulamos as teses da Teoria Marxista da Dependência sobre os tipos de desenvolvimento capitalista dependente e as distintas modalidades do padrão neoliberal. Defendemos a necessidade de mudanças estruturais para a transição a uma fase de superação da dependência.Palavras-chaves: capitalismo dependente; crise capitalista; neoimperialismo; neoliberalismo; Estado. RESUMENCon el fin de contribuir a la comprensión de la realidad social latinoamericana en la actual fase neoimperialista, retomamos los aportes de Ruy Mauro Marini sobre el capitalismo dependiente y las transformaciones históricas de los patrones de reproducción del capital. Considerando la relación dialéctica entre dependencia e imperialismo; la codeterminación entre Estado y capital, y la crisis estructural capitalista como característica del neoimperialismo, articulamos los planteamientos de la Teoría Marxista de la Dependencia sobre los tipos de desarrollo capitalista dependiente y las modalidades diferenciadas del patrón neoliberal. Planteamos la necesidad de cambios estructurales para transitar a una fase de superación de la dependencia.Palabras claves: capitalismo dependiente; crisis capitalista; neoimperialismo; neoliberalismo; Estado.ABSTRACTWith the aim to contribute to the understanding of the Latin American social reality in the current neo-imperialist phase, we return to Ruy Mauro Marini's contributions to dependent capitalism and the historical transformations of capital reproduction patterns. Considering the dialectical relationship between dependency and imperialism; the co-determination between the State and capital, and the capitalist structural crisis as a characteristic of neo-imperialism, we articulate the approaches of the Marxist Dependency Theory on the types of dependent capitalist development and the differentiated modalities of the neoliberal pattern. We raise the need for structural changes to move to a phase of overcoming dependency.Keywords: dependent capitalism; crisis of capitalism; neoimperilism; neoliberalism; State.

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Matheswaran, Palanisamy, Nageswar Bandla, Shashank Dhandiganaahalli, and Claire Mcmullen. "191: An Observational Study of Co-Infections Among COVID-19 Patients in a University Hospital ICU." Critical Care Medicine 49, no. 1 (December 11, 2020): 81. http://dx.doi.org/10.1097/01.ccm.0000726652.38597.eb.

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Xiong, Chuanfeng, Wei Huang, Xiaoli Nie, Ying Huang, Yiqun Jiao, Yujing Zou, Charles Huang, et al. "Microrna-191 Regulates T-Cell Clonal Expansion during Graft-Versus-Host Disease." Blood 134, Supplement_1 (November 13, 2019): 4433. http://dx.doi.org/10.1182/blood-2019-130179.

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Allogeneic hematopoietic cell transplantation is a potentially curative treatment choice for a wide variety of hematological malignancies. However, graft-versus-host disease (GVHD), which is mediated by donor alloreactive T cells, limits the success of this procedure. Previous studies have demonstrated that several microRNAs (miRs) modulate graft-versus-host disease. miR-191 was previously reported to be able to support T cell survival after TCR stimulation. We hypothesize that miR191 regulates T cell response during GVHD. To test this hypothesis, we first studied miR-191 expression in alloreactive T cells. The result demonstrated that miR-191 was up-regulated in donor T cells isolated from murine GVHD recipients, suggesting that miR-191 may play a role in GVHD induction. We further studied the role of miR-191in GVHD using miR-191 deficient T cells (KO). Lethally irradiated (8.5 Gy) BALB/c mice were injected intravenously with 1×107 T cell-depleted bone marrow (TCDBM) cells along with 1×106 purified T cells from wild-type (WT) or KO mice, which are in C57BL/6 background. Interestingly, all recipients in the WT group died within 35 days after transplantation, while only one out of ten animals died in the KO group during an observation period of 56 days. Body weights and clinical scores were also improved in KO T cell recipients when compared with the WT controls. Similar results were also observed in a second GVHD model (C57BL/6→C3H/HeJ). To understand the mechanism by which miR-191 KO T cells have decreased ability to mediate GVHD, we first measured the ability of KO T cells to respond to alloantigens in vitro in a mixed lymphocytes reaction assay. Dramatically decreased alloresponse was observed with KO T cells as compared with WT T cells. Similarly, decreased clonal expansion was observed in KO T cells in vivo upon challenge with alloantigens as measured by bioluminescent imaging (Figure 1A). These results were further supported by data from a co-transfer experiment, in which equal numbers of WT and KO T cells were transplanted into the same GVHD recipient. At day7 after transplantation, KO T cells showed significantly reduced expansion in the spleen and liver compared with WT T cells. Reduced alloresponses mediated by KO T cells may not due to decreased proliferative capability directly as an in vivo carboxyfluorescein succinimidyl ester (CFSE) assay showed a comparable cell division between WT and KO T cells upon challenge with alloantigens. Rather, increased cell death is responsible for decreased alloresponse observed in KO T cells because dramatically increased number of dead cells was observed in KO group compared with WT group upon response to alloantigens in vitro and vivo. To determine the genes that are regulated by miR-191, we did a screening based on the prediction. Humans and mice share more than 100 predicted targets for miR-191. We chose top 20 of these targets for RT-qPCR screening. The result demonstrated that Taf5 was a target gene of miR-191. Expression of TAF5 protein was down-regulated in activated KO T cells when compared with the WT T cells. Finally, we investigated whether miR-191 KO T cells preserve graft-versus-leukemia effects. 1×106 T cells from WT or KO mice were transplanted into lethally irradiated BALB/c mice along with 1×107 TCDBM cells and 1×105 host-type BCL-1 cells. While all recipients that received only TCDBM and tumor cells developed lethal leukemia/lymphoma, none of WT and KO T cells recipients developed tumor. In conclusion, our findings reveal a critical role of miR-191 during GVHD process and demonstrate that miR-191 is a novel therapeutic target for GVHD. Figure 1 Disclosures No relevant conflicts of interest to declare.

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Singh, P. K., Rohit K. Shrivastava, and K. G. Sinha. "Study And Evaluation of Injection Timing of CIDI Engine Injection Pump Using Alternate Fuel i.e Biodiesel Fuel." SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology 8, no. 01 (June 25, 2016): 11–19. http://dx.doi.org/10.18090/samriddhi.v8i1.11407.

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In this investigation an experimental study of the effects of FIP injection timing on Specific Fuel Consumption(SFC), Brake Thermal Efficiency(BTE), Engine Exhaust Gas Temperature(EEGT), CO, HC, NOX and Smoke of “Kirloskar- 6R1080TA, 6-CylinderInline, Direct Injection, Turbocharged Intercooled, 191 hp Diesel Engine” has been conducted. Injection Timing retardation method has been utilised to reduce SFC, EEGT, CO, HC, NOX, Smoke and increase BTE of Kirloskar-6R1080TA Diesel Engine. The Kirloskar 6R1080TA engine has been tested for six different injection timings (23°, 21°, 20°, 19°, 18° and 17° CA BTC) at same engine speeds and load conditions. The SFC,EEGT, CO, HC, NOX and Smoke of engine are approximately higher and BTE lower for injection timings at 23°, 21°, 20°, 18° and 17° CA BTC than 19° CA BTC at same speed and load. The results are showing that SFC,EEGT,CO,HC,NOX and Smoke are approximately reduces and BTE increases by reducing injection timing from 23° CA BTC to 19° CA BTC. Optimum FIP injection timing for Kirloskar 6R1080TA engine has been achieved at 19° CA BTC.

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Briganti, Fabrizio, Andrea Scozzafava, and Claudiu T. Supuran. "Carbonic Anhydrase Activators. Part 191 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines." Metal-Based Drugs 4, no. 4 (January 1, 1997): 221–27. http://dx.doi.org/10.1155/mbd.1997.221.

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The interactions of Zn(II)- and Co(II)-substituted carbonic anhydrase (CA) isozymes I and II with amine type activators such as histamine, serotonin, phenetylamine dopamine and benzylhydrazine have been investigated kinetically, and spectroscopically. All of such activators are of the non-competitive type towards CO2 hydration and 4-nitrophenylacetate hydrolysis for both human isozymes (HCA I and HCA II). The electronic spectra of the adducts of Co(II)CA with amine activators are similar to the spectrum of the previously reported Co(II)CAII-phenol adduct, the only known competitive inhibitor towards CO2 hydration, where the phenol molecule binds into the hydrophobic pocket of the active site. This is a direct spectroscopic evidence that the activator molecules bind within the active site, but not directly to the metal ion. Recent X-ray crystallographic data for the adduct of HCA II with histamine show that the activator molecule is bound at the entrance of the active site cavity, near to residues His 64, Asn 62 and Gln 92, where actively aids in shuttling protons between the active site and the environment. Similar arrangements probably occur for the other activators reported in the present paper.

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Börker, Janine, Jens Hartmann, Gibran Romero-Mujalli, and Gaojun Li. "Aging of basalt volcanic systems and decreasing CO<sub>2</sub> consumption by weathering." Earth Surface Dynamics 7, no. 1 (February 6, 2019): 191–97. http://dx.doi.org/10.5194/esurf-7-191-2019.

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Abstract. Basalt weathering is one of many relevant processes balancing the global carbon cycle via land–ocean alkalinity fluxes. The CO2 consumption by weathering can be calculated using alkalinity and is often scaled with runoff and/or temperature. Here, it is tested if the surface age distribution of a volcanic system derived by geological maps is a useful proxy for changes in alkalinity production with time. A linear relationship between temperature normalized alkalinity fluxes and the Holocene area fraction of a volcanic field was identified using information from 33 basalt volcanic fields, with an r2=0.93. This relationship is interpreted as an aging function and suggests that fluxes from Holocene areas are ∼10 times higher than those from old inactive volcanic fields. However, the cause for the decrease with time is probably a combination of effects, including a decrease in alkalinity production from material in the shallow critical zone as well as a decline in hydrothermal activity and magmatic CO2 contribution. The addition of fresh reactive material on top of the critical zone has an effect in young active volcanic settings which should be accounted for, too. A comparison with global models suggests that global alkalinity fluxes considering Holocene basalt areas are ∼60 % higher than the average from these models imply. The contribution of Holocene areas to the global basalt alkalinity fluxes is today however only ∼5 %, because identified, mapped Holocene basalt areas cover only ∼1 % of the existing basalt areas. The large trap basalt proportion on the global basalt areas today reduces the relevance of the aging effect. However, the aging effect might be a relevant process during periods of globally intensive volcanic activity, which remains to be tested.

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Markarian, Thibaut, Laura Grau-Mercier, Céline Occelli, Florian Ajavon, Pierre-Géraud Claret, Fabien Coisy, and Xavier Bobbia. "Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets." Journal of Clinical Medicine 11, no. 18 (September 15, 2022): 5420. http://dx.doi.org/10.3390/jcm11185420.

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Background: Cardiac output (CO) monitoring is recommended in patients with shock. The search for a reliable, rapid, and noninvasive tool is necessary for clinical practice. A new echocardiographic CO flow index (COF) is the automatic calculation of the sub-aortic VTI multiplied by the automatic calculation of the heart rate (HR). The primary objective of this study was to show the correlation between COF and CO measured by thermodilution (COth) in a controlled hemorrhagic shock model in anesthetized piglets. Secondary objectives were to show the correlation between COth and CO calculated from left outflow tract (LVOT) measurement and manual VTI (COman), and CO measured by LVOT measurement and VTIauto (COauto). Methods: Prospective interventional experimental study. In seventeen ventilated and anesthetized piglets, a state of hemorrhagic shock was induced, maintained, then resuscitated and stabilized. The gold standard for CO and stroke volume measurement was thermodilution (COth). Results: 191 measurements were performed. The correlation coefficients (r) between COth and COF, COman, and COauto were 0.73 [0.62; 0.81], 0.66 [0.56; 0.74], and 0.73 [0.63; 0.81], respectively. Conclusions: In this study, the COF appears to have a strong correlation to the COth. This automatic index, which takes into account the HR and does not require the measurement of LVOT, could be a rapidly obtained index in clinical practice.

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Raslavičius, Laurencas, and Žilvinas Bazaras. "THE ANALYSIS OF THE MOTOR CHARACTERISTICS OF D‐RME‐E FUEL BLEND DURING ON‐FIELD TESTS." TRANSPORT 24, no. 3 (September 30, 2009): 187–91. http://dx.doi.org/10.3846/1648-4142.2009.24.187-191.

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A detailed analysis of the characteristics of D‐RME‐E (diesel‐rapeseed methyl ester‐ethanol) was carefully performed fuelling an 18 kW capacity tractor unit equipped with the four‐stroke D21A1 diesel engine (combustion chamber consists of a dished piston). The conducted on‐field test demonstrated a positive effect on the dynamic and ecological characteristics of the tractor unit while fuelling the engine with biodiesel blend 70%D+30%RME (hereinafter ‐ B30) admixed with dehydrated ethanol additive (5% (v/v)). This compound did not affect a decrease in the diesel engine power, and in the range of experiment error, showed a tendency of ∼2% fuel economy compared to pure B30. A dramatic decrease in PM (40%), HC (25%) and CO (6%) emissions comparing to fossil diesel was observed when operating the tractor unit at maximum traction power which is a characteristic operating mode of the heavy duty transport means of agricultural purpose. NOx emission of the proposed D‐RME‐E blend showed a tendency to decrease to 4% compared to B30.

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Fu, S., J. M. Lu, and F. Q. Yuan. "Multivariate analysis of Co, Fe and Ni leaching from tailings following simulated temperature change." IOP Conference Series: Earth and Environmental Science 191 (November 5, 2018): 012125. http://dx.doi.org/10.1088/1755-1315/191/1/012125.

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NUYEN, JASPER, ANITA C. VOLKERS, PETER F. M. VERHAAK, FRANÇOIS G. SCHELLEVIS, PETER P. GROENEWEGEN, and GEERTRUDIS A. M. VAN DEN BOS. "Accuracy of diagnosing depression in primary care: the impact of chronic somatic and psychiatric co-morbidity." Psychological Medicine 35, no. 8 (April 18, 2005): 1185–95. http://dx.doi.org/10.1017/s0033291705004812.

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Background. Depression is highly co-morbid with both psychiatric and chronic somatic disease. These types of co-morbidity have been shown to exert opposite effects on underdiagnosis of depression by general practitioners (GPs). However, past research has not addressed their combined effect on underdiagnosis of depression.Method. Co-morbidity data on 191 depressed primary-care patients selected by a two-stage sampling procedure were analysed. Diagnoses of major depression and/or dysthymia in the last 12 months were assessed using a standardized psychiatric interview (CIDI) and compared with depression diagnoses registered by GPs in patient contacts during the same period. Presence of psychiatric and chronic somatic co-morbidity was determined using the CIDI and contact registration, respectively.Results. Regression analysis showed a significant interaction effect between psychiatric and chronic somatic co-morbidity on GPs’ diagnosis of depression, while taking into account the effects of sociodemographic variables, depression severity and number of GP contacts. Subsequent stratified analysis revealed that in patients without chronic somatic co-morbidity, a lower educational level, a less severe depression, and fewer GP contacts all significantly increased the likelihood of not being diagnosed as depressed. In contrast, in patients with chronic somatic co-morbidity, only having no psychiatric co-morbidity significantly decreased the likelihood of receiving a depression diagnosis.Conclusions. Our results indicate that the effects of psychiatric co-morbidity and other factors on underdiagnosis of depression by GPs differ between depressed patients with and without chronic somatic co-morbidity. Efforts to improve depression diagnosis by GPs seem to require different strategies for depressed patients with and without chronic somatic co-morbidity.

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Ashfaq, Mahnoor, Sadia Shafique, Zenab Niazi, Syed Yasir Shah, Siraj Memon, Kashifa Qureshi, and Faizan Banaras. "Occurence of urinary tract infections in type 2 diabetes mellitus patients taking Sodium-Glucose Co-Transporter-2 (SGLT-2) inhibitors to regulate their blood sugar levels." International journal of health sciences 7, S1 (June 28, 2023): 1999–2005. http://dx.doi.org/10.53730/ijhs.v7ns1.14444.

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Background and Aim: The occurrence of urinary tract infection (UTI) in type 2 diabetes (T2DM) administered with sodium glucose co-transporter-2 (SGLT2) inhibitors are still debatable. The present study aimed to assess the occurrence of UTI in T2DM patients taking SGLT-2 inhibitors to regulate their blood sugar levels. Patients and Methods: This cross-sectional study was carried out on 369 T2DM patients investigated in the Nephrology division of Khyber Teaching Hospital, Peshawar from January 2022 to December 2022. Dapagliflozin and empagliflozin were SGLT-2 inhibitors drugs given to each individual. Patient’s detailed history and genitourinary infections were noted from medical records. Pain during micturition, micturition urgency, redness, abdominal pain, vomiting, and frequency of micturition, fever, soreness, and diarrhea were recorded using questionnaire based proforma. Results: Of the total 369 patients, the frequency of patients administered with dapagliflozin and empagliflozin was 178 (48.2%) and 191 (51.8%) respectively. Among 178 patients, there were 112 (62.9%) male and 66 (37.1%) females. Among 191 patients, there were 136 (71.2%) male and 55 (28.8%) females. The occurrence of UTIs in patients using dapagliflozin and empagliflozin was 18 (10.1%) and 28 (14.7%) respectively.

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Buchanan, James M. "The Economics of Rights, Co-operation, and Welfare, Robert Sugden. Oxford: Basil Blackwell, 1986, vii + 191 pages." Economics and Philosophy 4, no. 2 (October 1988): 341–42. http://dx.doi.org/10.1017/s0266267100001176.

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Zhou, Chang-Fu, Jiahao Wang, and Ziheng Zhu. "A new wing skeleton of <i>Forfexopterus</i> (Pterosauria: Ctenochasmatidae) from the Early Cretaceous Jehol Biota reveals a developmental variation." Fossil Record 23, no. 2 (October 9, 2020): 191–96. http://dx.doi.org/10.5194/fr-23-191-2020.

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Abstract. In the Jehol Biota, the filter-feeding ctenochasmatid pterosaurs flourished with a high biodiversity. Here, we report a new wing skeleton of the ctenochasmatid Forfexopterus from the Early Cretaceous Jiufotang Formation in Jianchang, western Liaoning, China. The specimen exhibits the sole autapomorphy, the first wing phalanx shorter than the second and longer than the third. Interestingly, it exhibits a skeletal maturity with co-ossified elements, but it is only about 75 % the size of the immature holotype. This discrepancy reveals developmental variation of Forfexopterus, but its relationship with sexual dimorphism needs to be certain by more available material.

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Zhao, Chunzhao, Cees Waalwijk, Pierre JGM de Wit, Dingzhong Tang, and Theo van der Lee. "Relocation of genes generates non-conserved chromosomal segments in Fusarium graminearum that show distinct and co-regulated gene expression patterns." BMC Genomics 15, no. 1 (2014): 191. http://dx.doi.org/10.1186/1471-2164-15-191.

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Kelly, Ciara Marie, Timothy Geoffrey Bowler, Sandra P. D'Angelo, Mark Andrew Dickson, Mrinal M. Gounder, Mary Louise Keohan, Taylor Vonya, et al. "The clinical impact of performing routine next generation sequencing (NGS) in gastrointestinal stromal tumors (GIST)." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 11010. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.11010.

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11010 Background: The majority of GISTs harbor activating mutations in KIT or PDGFRα but the clinical relevance of other genomic alterations is unknown. We sought to determine the clinical impact of performing routine NGS and to describe the molecular landscape in GIST. Methods: From April 2014 to August 2016, 177 patients (pts) consented to an IRB-approved protocol. Tumor and matched normal samples were prospectively analyzed in a CLIA-compliant laboratory, with MSK-IMPACT, a NGS assay of up to 468 cancer-associated genes. Results: 191 samples were analyzed. NGS was most often performed in the setting of advanced disease (n = 108 (57%)). The primary tumor was most commonly tested (n = 120 (63%)). NGS guided clinical management in 79% (n = 150) of cases [matched therapy (MT) offered, n = 120/150 (80%); MT not offered, n = 24/150 (16%)]. In 25/41 cases (61%) where NGS did not influence management, treatment was not indicated because the GISTs were low risk. Most samples had ≤ 3 mutations (muts) (range: 0-17). Actionable muts were identified in 155/191 samples (81%). These included muts in KIT, PDGFRα and BRAF [oncoKB stratification: level 1 (84%), 2A (13%), 2B (2%), 3A(1%)]. 33/177 pts did not have a KIT/ PDGFRα mut [SDH deficiency, n = 15 (45%), NF1, n = 10 (30%), BRAF, n = 1(3%), NF1&BRAF, n = 1 (3%)]. 5pts had quadruple wild type GIST. Most GISTs had at least one genetic alteration in a non-driver allele (74%, n = 141/191)[frequently mutated genes in KIT exon 11 driven i) primary tumors include TP53, MAX, MLL2, SETD2, PIK3CA, TSC1; and ii) metastatic tumors include RB1, SETD2, PTEN, ANKRD11, TP53, TSC1]. CDKN2A deletion was the most common copy number alteration identified in KIT driven GIST and occurred most often in metastatic samples (with and without co-occurring, secondary KIT muts) and those with high mitotic rate. Conclusions: NGS of GIST informs clinical management in the majority of pts through the identification of muts in canonical driver genes. NGS also identifies a high prevalence of tumor-specific genetic alterations in non-canonical driver genes. These genes function in multiple pathways including intracellular signaling, chromatin remodeling, proteasomal degradation and cell cycle regulation.

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Ashfaq, Mahnoor, Sadia Shafique, Zenab Niazi, Syed Yasir Shah, Siraj Memon, Kashifa Qureshi, and Faizan Banaras. "Occurence of urinary tract infections in type 2 diabetes mellitus patients taking sodium-glucose co-transporter-2 (SGLT-2) inhibitors to regulate their blood sugar levels." International journal of health sciences 7, S1 (July 7, 2023): 1947–53. http://dx.doi.org/10.53730/ijhs.v7ns1.14435.

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Background and Aim: The occurrence of urinary tract infection (UTI) in type 2 diabetes (T2DM) administered with sodium-glucose co-transporter-2 (SGLT2) inhibitors are still debatable. The present study aimed to assess the occurrence of UTI in T2DM patients taking SGLT-2 inhibitors to regulate their blood sugar levels. Patients and Methods: This cross-sectional study was carried out on 369 T2DM patients investigated in the Nephrology division of Khyber Teaching Hospital, Peshawar from January 2022 to December 2022. Dapagliflozin and empagliflozin were SGLT-2 inhibitors drugs given to each individual. Patient’s detailed history and genitourinary infections were noted from medical records. Pain during micturition, micturition urgency, redness, abdominal pain, vomiting, and frequency of micturition, fever, soreness, and diarrhea were recorded using questionnaire based proforma. Results: Of the total 369 patients, the frequency of patients administered with dapagliflozin and empagliflozin was 178 (48.2%) and 191 (51.8%) respectively. Among 178 patients, there were 112 (62.9%) male and 66 (37.1%) females. Among 191 patients, there were 136 (71.2%) male and 55 (28.8%) females. The occurrence of UTIs in patients using dapagliflozin and empagliflozin was 18 (10.1%) and 28 (14.7%) respectively. Likewise, the genital tract infections were found in 20 (11.2%) dapagliflozin users and 26 (13.6%) empagliflozin users.

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Vourdoubas, John. "Possibility of Using Fuel Cells for Co-generation of Heat and Power in Venizelio Hospital in Crete, Greece." Environmental Management and Sustainable Development 11, no. 1 (January 10, 2022): 51. http://dx.doi.org/10.5296/emsd.v11i1.19191.

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Mitigation of climate change requires the replacement of traditional energy technologies with novel low carbon energy systems. The possibility of using a fuel cell and a hybrid energy system consisted of a fuel cell and solar-PV panel for energy generation in Venizelio hospital located in Crete, Greece has been investigated. The size, the heat and electricity generated, the H2 required and the capital cost of the fuel cell and the solar-PV system covering the energy requirements in the hospital have been estimated. Existing research has indicated that fuel cells using H2 can cover the heat and electricity needs in various buildings. Our results indicated that a fuel cell at 1 397 KW can produce annually 4 895 MWhel and 4 895 MWhth covering all the electricity and heating needs in Venizelio hospital producing excess heat at 2 451 MWhth. The capital cost of the fuel cell has been calculated at 4 191 000 € while the required H2 at 367.5 tons/year. All the energy requirements of the hospital can be also covered with a hybrid energy system consisted of a fuel cell and a solar-PV system. The size of the fuel cell has been estimated at 697.5 KW and the cost at 2 092 500 €. The electricity generation was at 2 444 KWhel and its heat production at 2 444 KWhth. The size of the solar-PV system has been evaluated at 1 629 KWp and the cost at 1 634 000 €.The annual electricity generation was at 2 451 MWhel. The capital cost of the hybrid energy system at 3 726 500 € is lower than the cost of the fuel cell alone at 4 191 000 €. Our results indicated that the use of novel benign energy systems with zero carbon emissions in Venizelio hospital is technically and economically feasible.

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I Nyoman Udayana. "Passive Imperatives in Indonesian." RETORIKA: Jurnal Ilmu Bahasa 8, no. 2 (October 24, 2022): 183–91. http://dx.doi.org/10.55637/jr.8.2.5755.183-191.

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An imperative clause is understood as a construction in which the subject is commonly filled by a second person but it is licitly dropped and the verb that co-occurs with it is commonly realized by a basic form in Indonesian. An active clause, on the other hand, contains an obligatory subject, the verb inflected with meN verbal prefix, and an object that makes the sentence readily transformed into its passive clause counterpart. Given the characteristic contrasts between an imperative clause and an active clause in Indonesian, it seems to be impossible to derive a passive imperative. However, imperative passives are available in Indonesian. The present study aims to uncover the issues of imperative passives in Indonesian. The study employs a descriptive qualitative method. Most of the data for the study were obtained from Leipzig Corpora and the remaining data were elicited from other speakers of Indonesian. Adopting the theory of a speaker commitment hypothesis for the analysis, the findings show that Indonesian has a passive imperative. This support can be evidenced by the fact that an imperative passive can be associated with a complex sentence construction in which the subject of the passive imperative clause can be recovered from the main clause thereby corroborating the idea that passive imperatives operate on a par with negative imperatives which possess prototypical passive constructions.

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Kaposi, Zoltán. "A dél-dunántúli gazdasági elit változásai." Jelenkori Társadalmi és Gazdasági Folyamatok 5, no. 1-2 (January 1, 2010): 187–91. http://dx.doi.org/10.14232/jtgf.2010.1-2.187-191.

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The previous economic and social elite lost its influence after the World War II. They were chased, sentenced to prison and many of them were tortured to death. The Commun-ist Party's local members were appointed to be managers of large estates and factories. They were the so called „worker directors". Their tasks were the dismissal of the previous managers and the launch of the planned-economy. Large estates were parceled in 1945. In the ages 1950 the owners of these parceled lands established farmers' co-operative. Some well-functioning manors were transformed to large state farms. The selection of executives was based on how loyal to the Communist Part they were. Because of these, the produc-tivity of the agriculture and the industry declined.

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Ghosh, Uzzal Kumar, Madhabi Baidya, Azmeri Sultana, Nobo Krishna Ghosh, M. F. Abiduzzaman, Joairya Yasmeen Bushra, and Md Maniruzzaman Nayan. "Co-infections and COVID-19 in Children: An Observational Study." Volume 5 - 2020, Issue 8 - August 5, no. 8 (August 22, 2020): 343–47. http://dx.doi.org/10.38124/ijisrt20aug156.

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Acute illness iscaused by bacteria, viruses, and parasites.Co-infection is the simultaneous infectionof a host by multiple pathogens resulting in a delay in diagnosis and bad prognosis.Currentlycorona virus infection is a pandemic and global health concern. Coronavirus infection in children withconcomitant other infections is rarely reported in our country. This study was performed to find out the corona virus infectionassociated with recent illnesses to minimize morbidity and mortality. Study was done at Dr. M R Khan Shishu Hospital & ICH from April 2020 to June 2020. Patient with fever, rash, vomiting, diarrhea, cough, respiratory distress, dysuria, convulsion, jaundice and other symptoms; admitted in hospital were taken for this study. Diagnosis was made by clinical symptoms plus investigations accordingly and appropriate treatment was given for recent illnesses. During follow up these cases; there was persistence of symptoms and some other new features appeared. These arouse our suspicion that there might be associated with corona virus infection in this pandemic. Thirty cases were taken co-infection with COVID19.Age was found 4 months to 8 years.Male female ratio was 1.5: 1.Typhoid fever with COVID-1912(40%), Bacterial meningitis with COVID-196(20%), UTI with COVID-19 3(10%), Paratyphoid fever with COVID192(6.7%), Typhus/ Rickettsial fever withCOVID-19 2(6.7%),HAV infection withCOVID-192(6.7%),HEV infection withCOVID-19 1 (3.3%), Septic arthritis with COVID-191 (3.3%), Atypical pneumonia with COVID191 (3.3%) were found. RT-PCR was positive forCOVID-1930(100%), blood culture was positive for Salmonella Typhi 4(13.3%), Widal test was reactive (high rising titer) 8(26.7%), Latex agglutination test was positive for bacterial meningitis 6(20%), urine culture was positive for E.coli 3(10%), blood culture was positive for Salmonella Para typhi A 2(6.7%), Weil-Felix reaction was found (high rising titer) 2(6.7%), Anti HAV IgM was positive 2(6.7%), Anti HEV IgM was positive 1(3.3%), Blood culturewas positive for Septic arthritis 1(3.3%), blood culture was positive for Mycoplasma Pneumoniae 1(3.3%). This study showed that COVID-19 in Bangladeshi children was found associated with co-infections. So, coinfection with COVID-19 patients should be closely monitored and managed accordingly.

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Dębowska CSFA, Krystyna. "Warszawski Zakład Dobroczynny „Przytulisko” miejscem powstania Zgromadzenia Sióstr Franciszkanek od Cierpiących." Nasza Przeszłość 131 (June 30, 2019): 169–91. http://dx.doi.org/10.52204/np.2019.131.169-191.

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W trudnej sytuacji Królestwa Polskiego, uzależnionego od rosyjskiego zaborcy, w drugiej połowie XIX wieku, dzięki ożywieniu religijnemu społeczności Warszawy, powstaniu i działalności bractw: miłosierdzia, różańcowych i franciszkańskich, doszło w 1858 roku do zorganizowania zakładu dobroczynnego dla kobiet pod nazwą Przytulisko. Mimo starań świeckiego zarządu zakładu i ofiar członków bractw, funkcjonowanie instytucji wymagało stałej obecności osób zatroskanych o jego codzienny byt. Stąd też starano się o oddanie zakładu jakiemuś zgromadzeniu zakonnemu, m.in. sióstr służebniczek z Wielkopolski, a także felicjanek z Warszawy. Po nieudanych próbach, po kasacie zgromadzeń zakonnych habitowych w 1864 roku, w latach 80-tych z inspiracji o. Honorata Koźmińskiego OFMCap, w warunkach konspiracyjnych usiłowano stworzyć w Przytulisku nowe zgromadzenie zakonne bezhabitowe. W tym celu kierownictwo zakładem objęła Kazimiera Gruszczyńska, członkini powstałego w latach 70-tych pierwszego ukrytego Zgromadzenia Sióstr Posłanniczek Serca Jezusowego. W trakcie organizowania wspólnoty zakonnej napotkała wiele trudności, zarówno ze strony zarządu Przytuliska nieświadomego jej zamiaru, jak też z powodu jej przynależności do innego zgromadzenia. Postawa, zdolności organizacyjne Gruszczyńskiej, zaradność w kierowaniu zakładem, sprawiły, że zyskała zaufanie zarządu i większą swobodę w działaniu. Po wtajemniczeniu niektórych członków zarządu zakładu w jej plany zakonotwórcze, doszło do powstania w nim nowego zgromadzenia zakonnego Sióstr Franciszkanek od Cierpiących. Dzięki patriotycznej i religijnej postawie członków zarządu Przytuliska i warszawskich życzliwych lekarzy, doceniających pracę sióstr wśród chorych, powstało Towarzystwo Pielęgnowania Chorych, tożsame ze zgromadzeniem, co umożliwiło jego egzystencję nowego zgromadzenia wobec ówczesnego prawa i władz rządowych.

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Gloss, Lisa M., Daniel E. Spencer, and Jack F. Kirsch. "Cysteine-191 in aspartate aminotransferases appears to be conserved due to the lack of a neutral mutation pathway to the functional equivalent, alanine-191." Proteins: Structure, Function, and Genetics 24, no. 2 (February 1996): 195–208. http://dx.doi.org/10.1002/(sici)1097-0134(199602)24:2<195::aid-prot6>3.0.co;2-i.

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Rocha de Souza Drumond, Adriana, Efraim Lázaro Reis, Maria Adelaide Vasconcelos Rabelo Veado, and José Márcio Quintão Moreira. "UTILIZAÇÃO DE MAPAS AUTO-ORGANIZÁVEIS PARA VERIFICAÇÃO DA DISTRIBUIÇÃO DE METAIS NA ATMOSFERA DE IPATINGA, MINAS GERAIS, ATRAVÉS DE BIOMONITORAMENTO COM Sphagnum capillifolium." Eclética Química Journal 39, no. 1 (July 9, 2014): 175. http://dx.doi.org/10.26850/1678-4618eqj.v39.1.2014.p175-191.

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This paper refers to the active biomonitoring moss bag of air quality of Ipatinga - MG, using Sphagnum capillifolium, determining the metals Al, Ca, Cd, Cr, Co, Cu, Fe, In, Li, Mg, Mn , Ni, Pb, Sn, Sr, Tl and Zn adsorbed on plant material through the analytical technique of Optical Emission Spectrometry with Inductively Coupled Plasma (ICP-OES). The self-organizing maps have proved useful to visualize the similarities and differences of samples and variables, making a positive correlation with the experimental observations. Both in the dry and in the rainy season, it was found that the majority of certain metals in plant samples were identified in the southern districts of this research, the regions predominant wind direction and close to local steel. In the dry period were higher concentrations of certain metals.

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Imai, Takasuke, Kenichirou Takahashi, Haruhiko Fukura, and Yasuo Morishita. "Measurement of Cardiac Output by Pulse Dye Densitometry Using Indocyanine Green." Anesthesiology 87, no. 4 (October 1, 1997): 816–22. http://dx.doi.org/10.1097/00000542-199710000-00015.

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Background A new method for determining cardiac output (CO, l/min) using dye dilution combined with pulse dye densitometry (PDD), based on the principle of pulse oximetry, has been developed. The aim of the study was to determine the accuracy and precision of PDD by comparing it with the thermodilution method. Methods A prospective study was performed in 22 patients having surgery who were monitored using a pulmonary arterial catheter. In addition to the catheter, a specially designed photodetector was placed on the nasal wing. Ten milliliters of ice-cold indocyanine green dissolved in a 5% glucose solution (0.5 mg/ml) was injected. The dye and thermal dilution curves were simultaneously measured to calculate CO. Three to six injections were performed before and after surgery. Paired data were assessed in absolute terms, and the percentage errors were calculated by the degree of agreement and compared at three levels of CO (low < or = 3.5 < medium < or = 6 < high) by analysis of variance. Results The mean and SDs of the differences between dye and thermodilution CO were 0.16 +/- 0.80 l/min or 4.5 +/- 19.6% for 191 paired data. Measurement after surgery failed in one patient. The percentage error with low CO (9.3 +/- 19.3%) was greater (P < 0.05) than those obtained with other CO. Conclusions Pulse dye densitometry could measure CO repeatedly in patients having major surgery with the same degree of accuracy as the thermodilution method; however, a considerable degree of error was observed in some patients.

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Journal articles on the topic 'Co 191'

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