Academic literature on the topic 'Clonal fitness'
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Journal articles on the topic "Clonal fitness"
Wikberg, Sofie. "Fitness in Clonal Plants." Oikos 72, no. 2 (March 1995): 293. http://dx.doi.org/10.2307/3546232.
Full textWatson, Caroline J., A. L. Papula, Gladys Y. P. Poon, Wing H. Wong, Andrew L. Young, Todd E. Druley, Daniel S. Fisher, and Jamie R. Blundell. "The evolutionary dynamics and fitness landscape of clonal hematopoiesis." Science 367, no. 6485 (March 26, 2020): 1449–54. http://dx.doi.org/10.1126/science.aay9333.
Full textBurns, Thomas P. "Fitness in Clonal Organisms: A Special Case of Extensive Fitness." Oikos 65, no. 3 (December 1992): 535. http://dx.doi.org/10.2307/3545572.
Full textPan, Jean J., and Jason S. Price. "Fitness and evolution in clonal plants: the impact of clonal growth." Evolutionary Ecology 15, no. 4-6 (July 2001): 583–600. http://dx.doi.org/10.1023/a:1016065705539.
Full textBarrett, Spencer C. H. "Influences of clonality on plant sexual reproduction." Proceedings of the National Academy of Sciences 112, no. 29 (July 20, 2015): 8859–66. http://dx.doi.org/10.1073/pnas.1501712112.
Full textAvagyan, S., J. E. Henninger, W. P. Mannherz, M. Mistry, J. Yoon, S. Yang, M. C. Weber, J. L. Moore, and L. I. Zon. "Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis." Science 374, no. 6568 (November 5, 2021): 768–72. http://dx.doi.org/10.1126/science.aba9304.
Full textSkums, Pavel, Viachaslau Tsyvina, and Alex Zelikovsky. "Inference of clonal selection in cancer populations using single-cell sequencing data." Bioinformatics 35, no. 14 (July 2019): i398—i407. http://dx.doi.org/10.1093/bioinformatics/btz392.
Full textDerbal, Youcef. "Cell Adaptive Fitness and Cancer Evolutionary Dynamics." Cancer Informatics 22 (January 2023): 117693512311546. http://dx.doi.org/10.1177/11769351231154679.
Full textFuzi, Miklos, and Evgeni Sokurenko. "Commensal Fitness Advantage May Contribute to the Global Dissemination of Multidrug-Resistant Lineages of Bacteria—The Case of Uropathogenic E. coli." Pathogens 12, no. 9 (September 10, 2023): 1150. http://dx.doi.org/10.3390/pathogens12091150.
Full textGordo, Isabel, and Paulo R. A. Campos. "Evolution of clonal populations approaching a fitness peak." Biology Letters 9, no. 1 (February 23, 2013): 20120239. http://dx.doi.org/10.1098/rsbl.2012.0239.
Full textDissertations / Theses on the topic "Clonal fitness"
Goho, Shaun Alaric. "The accumulation of variance in fitness in clonal populations of Chlamydomonas reinhardtii in normal and stressful environments." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/MQ29703.pdf.
Full textGoho, Shaun. "The accumulation of variance in fitness in clonal populations of Chlamydomonas reinhardtii in normal and stressful environments /." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27328.
Full textThe second chapter extends the investigation from normal culturing conditions into stressful ones. Specifically, it considers the hypothesis that C. reinhardtii might increase its mutation rate as a general response to environmental stress. Stressed lines were found to display reduced mean fitness and an increased variance of fitness after being returned to normal culturing conditions. This was interpreted as evidence for increased mutation rates in treated lines relative to controls. Possible mechanisms underlying this phenomenon are discussed, along with suggestions for further research.
Bertrand, Alexis. "Caractérisation fonctionnelle de mutations somatiques compensatrices d'elF6 dans le contexte du syndrome de Shwachman- Diamond." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL089.
Full textShwachman Diamond syndrome (SDS) is a rare genetic ribosomopathy leading to impaired protein synthesis, which causes numerous symptoms including bone marrow failure and neutropenia that can evolve to myelodysplasia syndrome or acute myeloid leukaemia. Biallelic mutations in the SBDS gene are responsible of above 90% of the SDS cases and we recently identified biallelic EFL1 mutations as a novel cause of SDS. SBDS together with EFL1 remove the anti-association factor elF6 from the pre60S ribosomal subunit, allowing its interaction with the 40S subunit to form the mature ribosome 80S. Natural acquisition of somatic genetic events over time participâtes to age-related diseases and cancer development. However, in Mendelian diseases these events can, in rare case, counteract the deleterious effect of the germline mutation and provide a sélective advantage to the somatically modified cells, a phenomenon dubbed Somatic Genetic Rescue (SGR). We recently showed that several somatic genetic events affecting the expression or function of elF6 are frequently detected in blood clones from SDS patients but not in healthy individuals, suggesting a mechanism of SGR. While most of these somatic mutations induce elF6 destabilization or EIF6 haploinsufficiency, one récurrent mutation (N106S) did not affect the expression of elF6 but rather impact its ability to interact with the 60S subunit. In order to further investigate the functional conséquences of ElF6 haploinsufficiency and N106S mutation in a context of SDS, I introduced via CRISPR/Cas9 these mutations in immortalized fibroblastic cell line from SDS patients and control. These original cellular models hâve made it possible to détermine the impact of the N106S mutation on the localisation and function of elF6 and also to clarify the effects of these mutations on several aspects of cellular fitness, in particular ribosome biogenesis, translation rate and cell prolifération. Overall, the development of these cellular models has helped to characterise how the somatic N106S mutation and elF6 haploinsufficiency confer a sélective advantage in cells déficient in SBDS or EFL1
Alqasim, A. S. "Determining the fitness and competitive advantage of the epidemic ExPEC clone E. coli ST131." Thesis, Nottingham Trent University, 2015. http://irep.ntu.ac.uk/id/eprint/27912/.
Full textAllander, Lisa. "Fitness and virulence of epidemic and non-epidemic clones of extensively drug-resistant (XDR) carbapenemase-producing Klebsiella pneumoniae." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-356714.
Full textFerriol, Safont Inmaculada. "FACTORS INVOLVED IN THE EVOLUTION OF BROAD BEAN WILT VIRUS 1 AND TOBACCO MOSAIC VIRUS." Doctoral thesis, Universitat Politècnica de València, 2012. http://hdl.handle.net/10251/16000.
Full textFerriol Safont, I. (2012). FACTORS INVOLVED IN THE EVOLUTION OF BROAD BEAN WILT VIRUS 1 AND TOBACCO MOSAIC VIRUS [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/16000
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Mariette, Nicolas. "Traits de vie,adaptation et pouvoir invasif de lignées clonales de Phytophthora infestans, agent du mildiou de la pomme de terre." Thesis, Rennes, Agrocampus Ouest, 2016. http://www.theses.fr/2016NSARA075/document.
Full textWest European populations of Phytophthora infestans, the oomycete causing late blight in potato, are characterized by a clonal structure and rapid replacement of dominant lineages. This work thus aimed to identify the ecological, phenotypic and evolutionary determinants of the invasive character of these clonal lineages. To this end, the phenotypic and genotypic population dynamics were analysed over two time scales, one over nearly a decade and a shorter one consisting in a longitudinal tracking over two consecutive epidemics. This monitoring was supplemented by the analysis of adaptive responses within these populations with respect to the main life-history traits of the parasite. These results tend to reject the hypothesis, often advanced, that the invasive ability is linked to a higher aggressiveness of the new clonal lineages compared to the previous ones. Moreover, the short-term study revealed complex scenario, involving the presence of two main clonal lineages (6_A1 and 13_A2)while 6_A1 isolates produced many, small sporangia, those of 13_A2 isolates are fewer but bigger. The coexistence within a single population of these strategies could result from the trade-off between the spore size and spore number, that we also demonstrated. Finally, differential responses between clones to temperature were observed, as well as clear local adaptation patterns among geographically distant populations. This work highlight that different adaptive factors can impact the same biological traits of P. infestans and that it is crucial to think about the consequences of these concom
Duprilot, Marion. "Étude comparative du clade émergent de Escherichia coli ST131 O25b H4 de son clade progéniteur : fitness in vitro et in vivo et formation de biofilm." Thesis, Université de Paris (2019-....), 2019. https://theses.md.univ-paris-diderot.fr/DUPRILOT_Marion_va.pdf.
Full textThe clade C of Escherichia coli ST131, an extra-intestinal pathogen (ExPEC) multidrug-resistant, emerged worldwide in the early 2000s. Understanding its expansion is one of the major public health challenges. To contribute to this understanding, we took into consideration the phylogenesis of ST131 and focused our research on comparing the clade C with its progenitor, the clade B, which is composed of strains globally sensitive to antibiotics.The phylogenesis of the clone ST131 describes the diversification of the ancestral clade B into different B subclades (from B1 to B5), B5 giving rise to clade C, which itself has diversified into two subclades, C1 and C2. We wanted to learn about the evolution of these different subclades in terms of relative frequency within all ExPECs. For this purpose, we analyzed the ST131 genomes identified within bacteriemic E. coli systematically collected in England between 2001 and 2012. This analysis showed that, during the studied period, (i) ST131 was one of the few dominant clones, with a dominance of clade C strains, particularly those of subclade C2 and (ii) clade B strains persisted in a stable manner, particularly those of subclades B4 and B5, despite an overall relative frequency lower than that of clade C. Besides, we have compiled a collection of 39 ST131 strains that have been found to be representative of the diversity of B and C clades and subclades, with the exception of one B4 strain (called Hybrid), which carries the fimH30 allele, normally specific to the clade C. Through this collection, we have explored the growth and formation of early biofilm (after 2, 3 and 5 hours of incubation) of clade B and C strains. All strains had equal growth capacities, while they differed in biofilm formation: biofilm was more frequently observed in 2 h in clade B strains than in clade C strains. Then, two representative strains of clades B and C, called Ancestor and Emergent, respectively, as well as Hybrid, were subjected to competitions two by two in vitro and in vivo (in various mouse models). Despite the absence of in vitro fitness differences between these three strains, Emergent was found to be less effective in colonizing the intestinal and/or urinary tract in mice and less virulent in the sepsis model than Ancestor and Hybrid. Referring to the non-functional fimB gene in all strains of clade C, a gene encoding one of the regulators of type 1 fimbriae synthesis involved in biofilm formation and bacterial adhesion, we have deleted it in Ancestor and Hybrid. Although the deletion of the fimB gene abolished in vitro the formation of early biofilm observed in parental strains, no effect was observed when mutants were put in competition with their parental strains, in vitro and in vivo; mutant and parental strain also behaved equally with regard to intestinal colonization and virulence in mice. In total, this work suggests that a global loss of virulence, a process known to improve the level of bacterial transmission, has occurred in ST131 clade C in addition to its acquisition of a multidrug resistance, two evolutions likely to ensure better fitness, especially in environments under antibiotic pressure
Books on the topic "Clonal fitness"
A, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.
Find full textA, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, N.J: Humana Press, 2003.
Find full textA, Machida Curtis, ed. Viral vectors for gene therapy: Methods and protocols. Totowa, New Jersey: Humana Press, 2003.
Find full textBirch, Jonathan. The Multicellular Organism as a Social Phenomenon. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198733058.003.0007.
Full textON CLONING. LONDON: ROUTLEDGE, 2004.
Find full textVoll, Reinhard E., and Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.
Full textMachida, Curtis A. Viral Vectors for Gene Therapy: Methods and Protocols (Methods in Molecular Medicine). Humana Press, 2002.
Find full textBook chapters on the topic "Clonal fitness"
Pan, Jean J., and Jason S. Price. "Fitness and evolution in clonal plants: the impact of clonal growth." In Ecology and Evolutionary Biology of Clonal Plants, 361–78. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-1345-0_20.
Full textBoomsma, Jacobus J. "Inclusive fitness as driver of cooperation for mutual benefit." In Domains and Major Transitions of Social Evolution, 105–29. Oxford University PressOxford, 2022. http://dx.doi.org/10.1093/oso/9780198746171.003.0005.
Full textRoff, Derek A. "Invasibility Analysis." In Modeling Evolution an introduction to numerical methods, 165–222. Oxford University PressOxford, 2009. http://dx.doi.org/10.1093/oso/9780199571147.003.0003.
Full textVoll, Reinhard E., and Barbara M. Bröker. "Innate vs acquired immunity." In Oxford Textbook of Rheumatology, 356–64. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048_update_001.
Full textConference papers on the topic "Clonal fitness"
Bolton, Kelly L., Ryan N. Ptashkin, Teng Gao, Lior Braunstein, Sean M. Devlin, Minal Patel, Antonin Berthon, et al. "Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5703.
Full textBulanova, Nina, Arina Buzdalova, and Maxim Buzdalov. "Fitness-Dependent Hybridization of Clonal Selection Algorithm and Random Local Search." In GECCO '16: Genetic and Evolutionary Computation Conference. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2908961.2908996.
Full textJameson, Katherine L., Peter L. Frick, Darren R. Tyson, Thomas E. Yankeelov, and Vito Quaranta. "Abstract 3747: Identification of NSCLC biomarkers underlying quantifiable drug-induced clonal fitness." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-3747.
Full textReports on the topic "Clonal fitness"
Morin, S., L. L. Walling, Peter W. Atkinson, J. Li, and B. E. Tabashnik. ets for CRISPR/Cas9-mediated gene drive in Bemisia tabaci. Israel: United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134170.bard.
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