Academic literature on the topic 'Clod tolerance in hibernators'

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Journal articles on the topic "Clod tolerance in hibernators"

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Jin-Rong, Liu, Liu Yuan, Chen Zuo, and Hwang Ping-Bo. "Comparison of cold tolerance in cerebral cortical neurons of hibernators and non-hibernators." Journal of Thermal Biology 12, no. 2 (July 1987): 69–72. http://dx.doi.org/10.1016/0306-4565(87)90039-8.

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Hoffstaetter, Lydia J., Karen J. Tonsfeldt, Vanessa Matos-Cruz, Slav N. Bagriantsev, and Elena O. Gracheva. "Probing the Contribution of Nav1.7 and Nav1.8 to Cold Tolerance in Hibernators." Biophysical Journal 110, no. 3 (February 2016): 318a. http://dx.doi.org/10.1016/j.bpj.2015.11.1710.

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Yasuma, Yoshihide, Richard M. McCarron, Maria Spatz, and John M. Hallenbeck. "Effects of plasma from hibernating ground squirrels on monocyte-endothelial cell adhesive interactions." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 6 (December 1, 1997): R1861—R1869. http://dx.doi.org/10.1152/ajpregu.1997.273.6.r1861.

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Adhesion and subsequent penetration of leukocytes into central nervous system ischemic tissue proceeds via a coordinated inflammatory mechanism involving adhesion molecules at the blood-endothelium interface. Mammalian hibernation is a state of natural tolerance to severely reduced blood flow-oxygen delivery (i.e., ischemia). Hibernating thirteen-lined ground squirrels were investigated in an attempt to identify factors responsible for regulating this tolerance. Since leukocytopenia is closely associated with entrance into hibernation, the role of leukocyte adhesion to endothelium in this phenomenon was examined. Intercellular adhesion molecule-1 (ICAM-1) is expressed by endothelium and regulates interactions with circulating leukocytes that may result in margination or extravasation. ICAM-1 expression by rat cerebral microvascular endothelial cells (EC) cultured with plasma from hibernating (HP) or nonhibernating (NHP) thirteen-lined ground squirrels was dose dependently increased by HP and, to a lesser extent, by NHP. Treatment of EC with HP coincidentally induced significantly greater increases in monocyte adhesion to EC (37.2%) than were observed with NHP (23.9%). Study of the effects of HP and NHP on monocyte adhesion to EC may identify mechanisms responsible for ischemic tolerance in hibernators and could lead to the development of novel therapeutic approaches to the treatment of stroke.
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Kuzmin, V. S., A. A. Abramov, Ju V. Egorov, and L. V. Rosenshtraukh. "Hypothermia induces postrepolarization refractoriness in the atrial myocardium of the hibernating and active ground squirrel Citellus undulatus." Доклады Академии наук 486, no. 5 (June 20, 2019): 631–37. http://dx.doi.org/10.31857/s0869-56524865631-637.

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The heart of the hibernating mammals demonstrates tolerance to the cold-induced arrhythmias and the electrophysiological mechanisms that underlie this phenomenon expecially in the atrial myocardium is still not elucidated. This study is aimed to the investigation of the hypothermia-induced changes of the atrial action potentials (AP) and refractoriness of the hibernating ground squirrel Citellus undulatus. APs were recorded with usage of standard sharp-electrode technique in the isolated, perfused multicellular continuously paced atrial myocardium preparations obtained from hibernating (HS) and summer active (SAS) squirrels. Action potentials duration (APD) and refractoriness duration (RD) were estimated at 37-17 °С and at various pacing cycle length (200-500 ms). It has been demonstrated that hypothermia causes prolongation of both APD and RD similarly in HS and SAS animals. However, the duration of the refractoriness in the atrial myocardium significantly exceeds the duration of the APs during hypothermia (27-17 °C). Revealed phenomenon may be considered as postrepolarization refractoriness (PRR). Proposed hypothermia-induced PRR probably substantially contributes to the insusceptibility of the hibernators to the cold induced arrhythmias by preventing the afterdepolarizations.
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Ohtsuki, Toshiho, Howard Jaffe, Michael Brenner, Nabil Azzam, Rita Azzam, Kai U. Frerichs, and John M. Hallenbeck. "Stimulation of Tyrosine Phosphorylation of a Brain Protein by Hibernation." Journal of Cerebral Blood Flow & Metabolism 18, no. 9 (September 1998): 1040–45. http://dx.doi.org/10.1097/00004647-199809000-00014.

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Mammalian hibernation is a state of natural tolerance to severely decreased brain blood flow. As protein tyrosine phosphorylation is believed to be involved in the development of resistance to potentially cell-damaging insults, we used immunoblotting for the phosphotyrosine moiety to analyze extracts from various tissues of hibernating and nonhibernating ground squirrels. A single, hibernation-specific phosphoprotein was detected in the brain, but not in any other tissue tested. This protein, designated pp98 to reflect its apparent molecular weight, is distributed throughout the brain, and is associated with the cellular membrane fraction. The presence of the protein is tightly linked to the hibernation state; it is not present in contemporaneously assayed animals that are exposed to the same cold temperature as the hibernators, is present for the duration of a hibernation bout (tested from 1 to 14 days), and disappears within 1 hour of arousal from hibernation. The close association of pp98 with the hibernation state, its presence in cellular membranes, and the known properties of membrane phosphotyrosine proteins suggest that it may transduce a signal for adaptation to the limited availability of oxygen and glucose and low cellular temperature that characterizes hibernation in the ground squirrel.
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Dissertations / Theses on the topic "Clod tolerance in hibernators"

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Smith, Timothy William. "Low temperature and cation transport in cardiac myocytes." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236212.

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