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Published: 9 March 2023
Last updated: 10 March 2023

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1

Cognetti, Gaetana, Biagio Paradiso, Ivana Truccolo, Donatella Ugolini, and Leonardo Santi. "Information Oncologic Tools Produced by the U.S. National Cancer Institute: How Much are They Known and Used? Results of an Enquiry in Italy." Tumori Journal 81, no. 5 (September 1995): 347–50. http://dx.doi.org/10.1177/030089169508100508.

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A survey was conducted among specialized users in order to establish the level of knowledge and diffusion of four informative tools: Cancerlit, PDQ, Clinprot, Cancergram. A questionnaire was distributed to 975 graduate researchers working in four national cancer research institutes in the north (2), center (1) and south (1) of Italy, as well as to the students of the Postgraduate School of Oncology (Oncology 2nd) of the “La Sapienza” University of Rome. Respondents were 486 (49.8%): only 167 (34.4%) declared to know Cancerlit, 56 (11.5%) PDQ, 10 (2%) Clinprot and 39 (8%) Cancergrams. Moreover, there is a time gap of nearly 6 years between the availability on-line of these tools and the information of its existence by the users. Most of the respondents were in favor of inserting courses on the use of information tools into the University curriculum and of training in the use of the tools.
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2

Komori, M., Y. Matsuyama, T. Nirasawa, M. Tanaka, H. Tomimoto, R. Takahashi, K. Tashiro, T. Kondo, and M. Ikegawa. "Profiling Cerebrospinal Fluid Proteins in Multiple Sclerosis by CLINPROT System." Journal of Proteomics & Bioinformatics S2, no. 01 (July 2008): 261–62. http://dx.doi.org/10.4172/jpb.s1000188.

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3

Bosso, Niccolò, Clizia Chinello, Stefano Carlo Maria Picozzi, Erica Gianazza, Veronica Mainini, Carmen Galbusera, Francesca Raimondo, et al. "Human urine biomarkers of renal cell carcinoma evaluated by ClinProt." PROTEOMICS - CLINICAL APPLICATIONS 2, no. 7-8 (July 2008): 1036–46. http://dx.doi.org/10.1002/prca.200780139.

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4

Fan, Nai-Jun, Chun-Fang Gao, Xiu-Li Wang, Guang Zhao, Qing-Yin Liu, Yuan-Yao Zhang, and Bao-Guo Cheng. "Serum Peptidome Patterns of Colorectal Cancer Based on Magnetic Bead Separation and MALDI-TOF Mass Spectrometry Analysis." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/985020.

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Background. Colorectal cancer (CRC) is one of the most common cancers in the world, identification of biomarkers for early detection of CRC represents a relevant target. The present study aims to determine serum peptidome patterns for CRC diagnosis.Methods. The present work focused on serum proteomic analysis of 32 health volunteers and 38 CRC by ClinProt Kit combined with mass spectrometry. This approach allowed the construction of a peptide patterns able to differentiate the studied populations. An independent group of serum (including 33 health volunteers, 34 CRC, 16 colorectal adenoma, 36 esophageal carcinoma, and 31 gastric carcinoma samples) was used to verify the diagnostic and differential diagnostic capability of the peptidome patterns blindly. An immunoassay method was used to determine serum CEA of CRC and controls.Results. A quick classifier algorithm was used to construct the peptidome patterns for identification of CRC from controls. Two of the identified peaks at m/z 741 and 7772 were used to construct peptidome patterns, achieving an accuracy close to 100% (>CEA,P<0.05). Furthermore, the peptidome patterns could differentiate validation group with high accuracy.Conclusions. These results suggest that the ClinProt Kit combined with mass spectrometry yields significantly higher accuracy for the diagnosis and differential diagnosis of CRC.
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5

He, Aili, Ju Bai, Chen Huang, Juan Yang, Wanggang Zhang, Jianli Wang, Yun Yang, Pengyu Zhang, and Fuling Zhou. "Detection of serum tumor markers in multiple myeloma using the CLINPROT system." International Journal of Hematology 95, no. 6 (April 27, 2012): 668–74. http://dx.doi.org/10.1007/s12185-012-1080-3.

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Xiang, YouZhang, Qun Xu, WuHong Tan, ShuLan He, XiaoWei Shi, WenMing Zhang, Jing Wang, XiuHong Wang, and WeiJuan Ma. "Serum Biomarkers of Keshan Disease Assessed Using a Protein Profiling Approach Based on ClinProt Technique." Protein Journal 33, no. 4 (May 20, 2014): 344–53. http://dx.doi.org/10.1007/s10930-014-9567-9.

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7

Hartwig, Sonja, Jorg Kotzka, Heidi Müller, Dirk Müller-Wieland, Jürgen Eckel, and Stefan Lehr. "Enhancing mass spectrometry based serum profiling by a combination of free flow electrophoresis and ClinProt™." Archives of Physiology and Biochemistry 115, no. 5 (November 4, 2009): 259–66. http://dx.doi.org/10.3109/13813450903286554.

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8

Hartwig, Sonja, Jorg Kotzka, Heidi Müller, Dirk Müller-Wieland, Jürgen Eckel, and Stefan Lehr. "Enhancing mass spectrometry based serum profiling by a combination of free flow electrophoresis and ClinProt™." Archives Of Physiology And Biochemistry 00, no. 00 (September 18, 2009): 090918020230064–8. http://dx.doi.org/10.1080/13813450903286554.

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9

Chinello, Clizia, Erica Gianazza, Italo Zoppis, Veronica Mainini, Carmen Galbusera, Stefano Picozzi, Francesco Rocco, et al. "Serum Biomarkers of Renal Cell Carcinoma Assessed Using a Protein Profiling Approach Based on ClinProt Technique." Urology 75, no. 4 (April 2010): 842–47. http://dx.doi.org/10.1016/j.urology.2009.09.050.

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10

Ziganshin, R. H., D. G. Alexeev, G. P. Arapidi, V. T. Ivanov, S. A. Moshkovskii, and V. M. Govorun. "Serum proteome profiling for diagnostics of ovarian cancer using ClinProt magnetic technique and MALDI-TOF mass spectrometry." Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 2, no. 4 (November 9, 2008): 335–42. http://dx.doi.org/10.1134/s1990750808040021.

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11

Zhang, Chun-yan, Shu-hong Wang, Wen-rong Huang, Guang-hong Guo, Zhu-hong Zhang, Wen-jun Mou, Li Yu, and Ya-Ping Tian. "A Novel Differential Predict Model Based on Matrix-Assisted Laser Ionization Time-of-Flight Mass Spectrometry and Serum Ferritin for Acute Graft-versus-Host Disease." BioMed Research International 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/563751.

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Clinical diagnosis of acute graft-versus-host disease (aGVHD) mainly depends on clinical manifestation and tissue biopsies, leading to a delayed diagnosis and treatment for aGVHD patients when the early symptom is insignificant. Our objective was to investigate the possibility of prewarning the risk of aGVHD before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) by serum protein profiling combined with serum ferritin. The difference in polypeptide expression before and after transplantation had been compared by using CLINPROT technology, and serum ferritin levels have been analyzed simultaneously. Through combining serum ferritin and MS spectral data, the diagnosis sensitivity and specificity of our model for prewarning severe aGVHD (III~IV°aGVHD) before transplant all increased to 90.0%, while after transplant, the sensitivity and specificity are 78.3% and 86.4%. Our joint prewarning model could predict the risk of aGVHD, especially severe aGVHD before and after transplant, which also provides a reliable method to the continuous monitoring of the condition of patients.
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12

Kikkawa, Shintaro, Kazuyuki Sogawa, Mamoru Satoh, Hiroshi Umemura, Yoshio Kodera, Kazuyuki Matsushita, Takeshi Tomonaga, Masaru Miyazaki, Osamu Yokosuka, and Fumio Nomura. "Identification of a Novel Biomarker for Biliary Tract Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry." International Journal of Proteomics 2012 (July 25, 2012): 1–8. http://dx.doi.org/10.1155/2012/108609.

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Early diagnosis of biliary tract cancer (BTC) is important for curative surgical resection. Current tumor markers of BTC are unsatisfactory in terms of sensitivity and specificity. In a search for novel biomarkers for BTC, serum samples obtained from 62 patients with BTC were compared with those from patients with benign biliary diseases and from healthy controls, using the MALDI-TOF/TOF ClinProt system. Initial screening and further validation identified a peak at 4204 Da with significantly greater intensity in the BTC samples. The 4204 Da peak was partially purified and identified as a fragment of prothrombin by amino acid sequencing. The sensitivity of the 4204 Da peptide for detection of stage I BTC cancer was greater than those for CEA and CA19-9. Also, serum levels of the 4204 Da peptide were above the cut-off level in 15 (79%) of 19 cases in which the CEA and CA19-9 levels were both within their cut-off values. Receiver operating characteristic analysis showed that the combination of the 4204 Da peptide and CA19-9 was significantly more sensitive for detection of stage I BTC cancer compared to CEA and CA19-9. These results suggest that this protein fragment may be a promising biomarker for biliary tract cancer.
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13

Graul, A., P. Leeson, and J. Castañer. "Clinprost." Drugs of the Future 22, no. 6 (1997): 608. http://dx.doi.org/10.1358/dof.1997.022.06.412127.

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14

Cheng, Ann-Joy, Li-Chiu Chen, Kun-Yi Chien, Yin-Ju Chen, Joseph Tung-Chieh Chang, Hung-Ming Wang, Chun-Ta Liao, and I.-How Chen. "Oral Cancer Plasma Tumor Marker Identified with Bead-Based Affinity-Fractionated Proteomic Technology." Clinical Chemistry 51, no. 12 (December 1, 2005): 2236–44. http://dx.doi.org/10.1373/clinchem.2005.052324.

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Abstract Background: There is no plasma marker for detecting oral cancer, one of the most frequent cancers worldwide. We developed a bead-based affinity-fractionated proteomic method to discover a novel plasma marker for oral cancer. Methods: Affinity purification of heparinized plasma with magnetic beads and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis were used to screen potential oral cancer markers. We compiled MS protein profiles for 57 patients with oral cancer and compared them with profiles from 29 healthy controls. The spectra were analyzed statistically using flexAnalysis™ and ClinProt™ bioinformatic software. In each MS analysis, the peak intensities of interest were normalized with an internal standard (adrenocorticotropic hormone 18–39). For identification, affinity bead–purified plasma protein was subjected to MALDI TOF/TOF analysis followed by Mascot identification of the peptide sequences and a search of the National Center for Biotechnology Information protein database. Results: To optimize MALDI-TOF analysis based on the best discriminator of the cancer and control spectra, copper-chelated beads were used for plasma protein profiling. The within- and between-run CVs for assays were &lt;4% and 7%, respectively. Six markers that differentiated between cancer and control spectra were found, with mean (SD) molecular masses of 2664 (1), 2850 (1), 3250 (1), 7735 (2), 7927 (2), and 9240 (2) Da. The 2664-Da marker, identified as a fragment of the fibrinogen α-chain, had the highest sensitivity (100%) and specificity (97%) for cancer. Conclusion: The high specificity and sensitivity of the fibrinogen α-chain fragment suggest that it may be a clinical useful tumor marker.
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15

Bai, Ju, Yun Yang, Jianli Wang, Wanggang Zhang, Lei Zhang, Fangxia Wang, Xiaman Wang, et al. "Serum Peptidome Based Biomarkers Searching for Monitoring Minimal Residual Disease in Adult Acute Monocytic Leukemia." Blood 128, no. 22 (December 2, 2016): 5233. http://dx.doi.org/10.1182/blood.v128.22.5233.5233.

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Abstract Background: Acute monocytic leukemia (M5) is one common type in acute myeloid leukemia (AML). The present study found that a few M5 had special reproducible chromosomal abnormalities and molecular abnormalities. The heterogeneity and complexity of M5 lead to lack of specific tumor-associated markers for molecular diagnosis and targeted therapy. CLINPROT system, with unique advantages, is a firenew and distinctive proteomics technology and has been widely used in the researches of solid tumor and hemopathic malignancies. This study was to screen a panel of serum peptides associated with M5 different disease states for molecular diagnosis and monitoring minimal residual disease. Methods: 92 M5 were enrolled for the study from those who were newly diagnosed (ND) in the Second Affiliated Hospital of Xi'an Jiao Tong University from January 2009 to July 2014. The median age was 45 years old (range 18-73) and 57.6% were male. Diagnosis was made according to bone marrow cell morphology, cytochemical staining and cellular immune phenotype. 90 healthy cases (HC) (age range 19-70, median age 43 years old, male/female 51/39) were recruited from those who came to our hospital to undergo healthy physical examination and had no any abnormal symptoms and results. Sera of 92 M5 were gained pre- and post-treatment of chemotherapy. Weak cation exchange magnetic bead combined with matrix assisted laser desorption/ ionization time of flight mass spectrometry were used to compare and analyze serum peptidome of M5 with different disease states. Spearman method was used to do correlation analysis of two variables. Statistical significance was defined as p<0.05. Results: A total of 42 peptides in the molecular weight range of 700-10000 Da were detected using ClinProt system and statistically different between adult M5 and healthy controls. Among them, 9 peptides were elevated and 33 were decreased in M5. Genetic algorithm (GA) was used to obtain a diagnostic model consisting of 6 peptides that could discriminate M5 from controls with a high sensitivity (100%) and specificity (96.67%). Mass charge ratios (m/z) were 6041.91, 4662.15, 7823.02, 9210.97, 1108.91 and 3263.37 respectively. Blind test verified that this model correctly identified 60 cases out of total 62 M5 and 57 cases from 60 healthy controls. The relative intensities of peptides with m/z of 6041.91 and 4662.15 were increased in the ND group and non-complete remission (CR) group, when comparing with the CR group and HC group(p=0.002; p<0.001), but there was no significant difference between the two groups for any of the peptides (p=0.27, p=0.31). No significant difference was found between the CR group and HC group (p=0.22, p=0.41). The relative intensities of peptides with m/z of 7823.02, 9210.97, 1108.91 and 3263.37 were reduced in the ND group and non-CR group when comparing with the CR group and HC group (p<0.001, p=0.0023, p=0.004, p<0.001), and the two groups had no significant difference (p=0.26, p=0.09, p=0.32, p=0.61). No significant difference was observed between the HC group and CR group (p=0.52, p=0.35, p=0.17, p=0.73). Spearman correlation analysis showed that relative intensities of peptides with m/z of 4662.15, 7823.02 and 9210.97 were correlated with high white blood cells (r=0.88, p<0.001; r=-0.89, p<0.001; p=-0.87, p<0.001), FLT3 mutation (r=0.90, p<0.001; r=-0.87, p<0.001; r=-0.88, p<0.001) , extramedullary disease (r=0.80, p<0.001; r=-0.86, p<0.001; r=- 0.82, p<0.001). The relative intensities of the other three peptides had weak correlation with the unfavorable clinical features of M5 at diagnosis. Conclusion: This panel of peptides has encouraging efficiency in discriminating M5 from HCs and potential value in monitoring M5 minimal residual disease. Disclosures No relevant conflicts of interest to declare.
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Kau, Chung H., Jue Wang, Anna Palombini, Nadia Abou-Kheir, and Terpsithea Christou. "Effect of fluoride dentifrices on white spot lesions during orthodontic treatment: A randomized trial." Angle Orthodontist 89, no. 3 (February 5, 2019): 365–71. http://dx.doi.org/10.2319/051818-371.1.

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ABSTRACT Objectives: To determine the effect of Clinpro 5000, Clinpro Tooth Crème, and MI-Paste Plus on the formation of white spot lesions in patients undergoing orthodontic treatment. Materials and Methods: Three prospective groups with 40 patients undergoing orthodontic treatment in each group were evaluated (total recruitment = 120 subjects). The selected product was brushed on for 2 minutes twice daily for 4 months. Subjects were reviewed for 4 months on a monthly basis. The Enamel Decalcification Index (EDI) was used to determine the number of white spot lesions per surface at each visit. Results: 100 subjects (35 using Clinpro 5000, 32 using Clinpro Tooth Crème, and 33 using MI Paste Plus) completed the study. The data lend strong support for Clinpro 5000 providing superior protection against enamel decalcification when compared to Clinpro Crème, and mixed support when compared to MI Paste Plus. Conclusions: The use of Clinpro 5000, Clinpro Crème, and MI paste Plus all have a reduction effect on white spot lesions when compared to studies reported previously. Clinpro 5000 has a marginally better effect than the two other test pastes. The results of this study can be used by clinicians when deciding the effectiveness of using fluoride dentifrice products to prevent white spot lesions in their orthodontic practice (ClinicalTrials.gov ID: NCT03440996).
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Umekubo, Nariyoshi, and Yujiro Hayashi. "Pot-Economical Total Synthesis of Clinprost." Organic Letters 22, no. 23 (November 24, 2020): 9365–70. http://dx.doi.org/10.1021/acs.orglett.0c03616.

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18

Barabde, Aparna S., Nitin Singh, Govind Agrawal, AV Subhash, S. Suneela, and G. Ajay Kumar. "A Comparative Evaluation of Shear Bond Strength of Different Pits and Fissure Sealants: An in vitro Study." Journal of Contemporary Dental Practice 14, no. 5 (2013): 917–23. http://dx.doi.org/10.5005/jp-journals-10024-1426.

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ABSTRACT Aim The aim of this study was to determine and compare the shear bond strength of three different pits and fissure sealants to enamel namely, Delton, Clinpro and Z350 Filtek flowable composite. Materials and methods Ninety permanent molars were divided into three groups of 30 each. Their proximal surfaces were prepared and stored in 37°C ± 5°C normal saline for 24 hours. Sealant buttons were prepared. The specimens were tested in a shear mode (Lloyds LR100K) at a crosshead speed of 0.5 mm/min. The mean and standard deviations were subjected to an analysis of variance. Results The mean shear bond strength of samples of Delton was 10.33 MPa; Clinpro was 8.51 MPa and Z350 Filtek flowable was 12.17 MPa. The mean strength of Delton was significantly higher as compared to Clinpro whereas the mean strength of Z350 Filtek was significantly higher as compared to Delton and Clinpro (Student t-test, p < 0.001). Conclusion Z350 Filtek flowable composite had maximum shear bond strength than Delton FS sealant followed by Clinpro sealant. Clinical significance In this study, we compare the bond strength of three pits and fissure sealant, Clinpro yielded lower bond strength than Delton. This outcome can be described due to the presence of fillers in Delton, since these particles increase the resistance of the material to abrasion and also increase the mechanical resistance of the material. How to cite this article Singh N, Agrawal G, Subhash AV, Suneela S, Barabde AS, Kumar GA. A Comparative Evaluation of Shear Bond Strength of Different Pits and Fissure Sealants: An in vitro Study. J Contemp Dent Pract 2013;14(5):917-923.
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Rohym, Shaimaa Mosutafa, Asmaa Youssif Harhash, and Mohammed Farid Riad. "One Year Clinical Evaluation of White Spot Lesions with Newly Introduced Resin Modified Glass-Ionomer in Comparison to Resin Infiltration in Anterior Teeth: a split mouth randomized controlled clinical trial from Egypt." Brazilian Dental Science 24, no. 1 (December 22, 2020): 13p. http://dx.doi.org/10.14295/bds.2021.v24i1.2063.

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Objective: to compare the clinical performance of newly introduced resin modified glass ionomer varnish (Clinpro™ XT) versus resin infiltration in treatment of post-orthodontic white spot lesions. Material and Methods: Six participants (70 teeth) were enrolled with post-orthodontic white spot lesions. Randomization was performed according to patient selection for the sealed envelope containing which half will receive the control (resin infiltration (ICON, DMG) and the other will receive the intervention (resin modified glass-ionomer cement varnish (Clinpro™ XT, 3M)). Follow up was done after 1 day, 1 week, 1 month, and 3 months, 6 months and 12 months. The color was assessed by spectrophotometer while the degree of demineralization was measured by Diagnodent pen 2910. Patient satisfaction was assessed using (VAS) Visual analogue scale. Results: Regarding color change, significant improvement in lightness for ICON group, while Clinpro™ XT group, the change was insignificant. The demineralization data revealed significant decrease in demineralization with resin infiltration after immediate application. Clinpro™ XT showed also significant decrease after immediate assessment and significant increase in demineralization in 6 and 12 months. Conclusion: Resin infiltration can be considered more as an alternative treatment rather than fluoride varnish. Clinpro™ XTis considered as a preventive protocol, provided that renewal application is needed after 3 months. Keywords 3M Resin cement; Resin cements; Glass ionomer cements; Fluorides; Follow up studies; Glass ionomer.
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Seixas, Gabriela Fleury, Sandrine Bittencourt Berger Guiraldo, Letícia Vargas Freire Martins Lemos, Silvio Issao Myaki, Ivan Balducci, and Sandra Kiss Moura. "Clinpro ™ XT Sealant Adhesion to the Occlusal Surface of Primary Molars: Longitudinal Evaluation." Journal of Health Sciences 20, no. 2 (July 27, 2018): 112. http://dx.doi.org/10.17921/2447-8938.2018v20n2p112-118.

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AbstractThe study aims to evaluate the bond strength of sealants on deciduous molars. Clinpro ™ XT, Vitremer ™, Fluroshield and Optibond FL materials were applied to the occlusal surface of 40 deciduous lower molars (n = 5). The teeth were prepared for the micro tensile test, obtaining a specimen in a stick format with a cross-sectional area of 0.8 mm2. After 24 hours and 6 months of restorative procedures, the specimens were traversed in universal test machine. The statistical analysis used the tooth as experimental unit, considering the adhesive and mixed fractures data, through Variance Analysis of repeated measures and Tukey tests (α = 0.05). There was a difference among the adhesion of the materials in 24 h, with higher union strength for Optibond FL (31.20 ± 1.36 MPa), significantly higher than that of Clinpro ™ XT (20.23 ± 1.16 MPa), Fluroshield (24.61 ± 2.76 MPa) and Vitremer™ (21.31 ± 2.32 MPa), which were similar. After 6 months of storage, the Clinpro ™ XT bond strength remained (22.18 ± 2.91 MPa), Optibond FL decreased (20.77 ± 1.53 MPa), but remained similar to that of Clinpro ™ XT in 6 months. The lowest adhesion values at 6 months were of Fluroshield (11.14 ± 1.98 Mpa) and Vitremer (5.29 ± 0.58 Mpa). It was concluded that the bond strength of the sealants to the occlusal surface of the deciduous molars was influenced by the material, with Clinpro ™ XT being the only material that maintained the bond strength values after 6 months.Keywords: Pit and Fissure Sealants. Tensile Strength. Tooth, Deciduous.ResumoO presente estudo teve como objetivo avaliar a adesão de selantes em molares decíduos. Os materiais Clinpro™ XT, VitremerTM, Fluroshield e Optibond FL foram aplicados na superfície oclusal de 40 molares inferiores decíduos (n=5). Os dentes foram preparados para o ensaio de microtração, com obtenção de corpo-de-prova em formato de palito com área de seção transversal de 0,8 mm2. Após 24 horas e 6 meses da realização dos procedimentos restauradores, os espécimes foram tracionados em máquina de ensaio universal. A análise estatística usou como unidade experimental o dente, considerando os dados de fraturas adesivas e mistas, pelos testes de Análise de Variância de medidas repetidas e Tukey (α=0,05). Houve diferença entre a adesão dos materiais em 24 h, com maior resistência de união para o Optibond FL (31,20 ±1,36 MPa), significativamente maior que a do Clinpro™ XT (20,23 ±1,16 MPa); Fluroshield (24,61 ±2,76 MPa) e VitremerTM (21,31 ±2,32 MPa) foram semelhantes. Decorridos 6 meses de armazenamento, a resistência de união do Clinpro™ XT se manteve (22,18 ±2,91 MPa) e a do Optibond FL diminuiu (20,77 ±1,53 MPa) mas se manteve semelhante à do Clinpro™ XT em 6 meses. Os menores valores de adesão em 6 meses foram do Fluroshield (11,14 ±1,98 Mpa) e do Vitremer (5,29 ±0,58 Mpa). Concluiu-se que a resistência de união dos selantes à superfície oclusal dos molares decíduos foi influenciada pelo material, sendo o Clinpro™ XT o único material que manteve os valores de resistência de união após 6 meses.Palavras-chave: Selantes de Fossas e Fissuras. Resistência à Tração. Dente decíduo.
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Xu, Lin, Yuchun Zou, Hanyu Lin, Xinhan Yang, and Linyu Xu. "An In Vitro Comparison of Clinpro™ XT and Duraphat Varnish for Protecting Teeth from Discoloration during Orthodontic Treatment." International Journal of Clinical Practice 2023 (February 8, 2023): 1–9. http://dx.doi.org/10.1155/2023/3951245.

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Objective. During orthodontic treatment, a higher caries risk has been reported, so fluorides and other remineralizing compounds have been proposed. Currently, fluoride varnish is commonly available in conventional and light-curable forms. This in vitro study was performed to evaluate the effectiveness of two different materials, Clinpro™ XT (light-curable forms) and Duraphat (conventional forms) varnish, whose main active principle according to their manufacturers is fluoride in preventing tooth discoloration during orthodontic treatment with appliances attached with metal brackets or resin. Materials and Methods. This study included 120 premolars free of white spot lesions and caries that were randomly divided into the following six groups (n = 20): resin control (RCTR), resin Clinpro (RC), resin Duraphat (RD), bracket control (BCTR), bracket Clinpro (BC), and bracket Duraphat (BD). All the samples were exposed to 180 ml of coffee (4 times × 5 min/day) for 7 or 28 days. When not immersed in coffee, the teeth were stored in artificial saliva, which was replaced every day. The lightness ( L ∗ ), red/green axis ( a ∗ ), and yellow/blue axis ( b ∗ ) values were recorded with a dental spectrophotometer (Easy shade Advance 4.0) on days 0 (baseline), 7, and 28. The color difference ( Δ E ∗ ) on days 7 and 28 was also calculated. Results. The data were statistically analyzed using one-way ANOVA and Bonferroni’s test (α = 0.05). Significant differences were observed between the Δ E ∗ , L ∗ , a ∗ , and b ∗ values of the Clinpro™ XT and Duraphat groups and those of the control groups after 7 and 28 days regardless of the attachment type ( P < 0.001). On day 7, no significant differences were observed between the Clinpro™ XT and Duraphat groups, whereas on day 28, the Duraphat groups with metal and resin attachments exhibited significant differences from the Clinpro™ XT groups ( P < 0.001). No significant differences correlated to the attachment type were observed throughout the discoloration procedure. Conclusions. The application of fluoride varnish during orthodontic treatment can significantly reduce tooth discoloration caused by the staining solution. Clinpro™ XT varnish showed a longer period of efficacy in protecting teeth from discoloration than Duraphat. No differences in tooth discoloration were observed between the groups with fixed and clear appliances.
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Aniwan, Satimai, David H. Bruining, Sang Hyoung Park, Badr Al-Bawardy, Sunanda V. Kane, Nayantara Coelho Prabhu, John B. Kisiel, et al. "The Combination of Patient-Reported Clinical Symptoms and an Endoscopic Score Correlates Well with Health-Related Quality of Life in Patients with Ulcerative Colitis." Journal of Clinical Medicine 8, no. 8 (August 5, 2019): 1171. http://dx.doi.org/10.3390/jcm8081171.

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Background and aims: Patient-reported outcomes (PROs) will become increasingly important as primary endpoints in future clinical trials. We aimed to evaluate the relationship between health-related quality of life (HRQoL) and the combination of patient-reported clinical symptoms (ClinPRO2) and Mayo endoscopic subscore (MES) in patients with ulcerative colitis (UC). Methods: We conducted a prospective cross-sectional study of 90 consecutive UC patients who were scheduled for sigmoidoscopy or colonoscopy. All patients completed the following questionnaires: (1) self-rated rectal bleeding and stool frequency (ClinPRO2); (2) Short Inflammatory Bowel Disease Questionnaire (SIBDQ); (3) European Quality of Life 5-Dimensions 3-Level (EQ5D3L); (4) Work Productivity and Activity Impairment questionnaire (WPAI); (5) Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and (6) Hospital Anxiety and Depression Scale (HADS). The endoscopic images were graded according to the MES. “No symptoms” was defined as a symptom score of 0, and “mucosal healing” was defined as MES score of 0–1. Correlations between the combined ClinPRO2 and MES with HRQoL were assessed using Spearman’s correlation coefficients. Results: The combination of the ClinPRO2 and MES was well correlated to SIBDQ (r = −0.70), EQ5D3L (r = −0.51), WPAI (r = 0.62), FACIT-F (r = −0.58), and HADS-depression (r = 0.45). SIBDQ scores had strong correlations with FACIT-F (r = 0.86), WPAI (r = −0.80), and HADS-depression (r = −0.75) (p < 0.05 for all correlations). Patients with no symptoms reported the greatest all HRQoL scores. Conclusions: In patients with ulcerative colitis, the combination of a ClinPRO2 and the MES had good correlation with the SIBDQ. In addition, SIBDQ was well correlated to the various HRQoL.
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Sharma, Harshul, Charu Gupta, Sophia Thakur, and Sanjeev Srivastava. "Comparative evaluation of calcium phosphate-based varnish and resin-modified glass ionomer-based varnish in reducing dentinal hypersensitivity: A randomized controlled clinical trial." European Journal of Dentistry 11, no. 04 (October 2017): 491–95. http://dx.doi.org/10.4103/ejd.ejd_127_17.

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ABSTRACT Objective: The aim of this study was to evaluate the efficacy of MI varnish and Clinpro XT varnish in reducing dentinal hypersensitivity. Materials and Methods: Patients with cervical dentinal hypersensitivity were selected for the study. The teeth to be tested were isolated. Then, a blast of air and ice cold water was applied on the tooth surface, and the score was measured by visual analog scale. The patients were randomly assigned to one of the treatment groups (Group 1: MI varnish; Group 2; Clinpro XT varnish). The manufacturer's instructions were followed. The sensitivity scores were recorded immediately and after 1 week of therapy. Statistical Analysis: Mann–Whitney U-test and Wilcoxon-matched pairs test were used for the analysis. Results and Conclusion: Although both varnishes were shown to reduce the dentinal hypersensitivity in patients, according to statistics, MI Varnish was a better agent to reduce dentinal hypersensitivity than Clinpro XT varnish.
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Rangel Padilla, Eyra Elvyra, Hector Alejandro Ramírez Peña, Hector Ramón Martínez-Menchaca, Gerardo Rivera Silva, Roberto Valencia Hitte, Maribel Lozano Longoria, Gustavo Israel Martínez González, and Roberto Espinosa Fernández. "Evaluación bajo microscopio electrónico de barrido de sellantes de fosas y fisuras hidrófobos e hidrófilos, bajo diferentes condiciones de humedad: Un estudio in vitro." Revista de Odontopediatría Latinoamericana 8, no. 1 (January 19, 2021): 17. http://dx.doi.org/10.47990/alop.v8i1.144.

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Objetivo: Evaluar el efecto de diferentes marcas de selladores de fosas y fisuras hidrófobos e hidrófilos en Microscopio electrónico de barrido de emisión de campo (MEB-EC) expuestos a humedad relativa. Materiales y Métodos: Se utilizaron 40 premolares extraídos con fines ortodóncicos, se dividieron al azar en 8 grupos: Grupo 1: sellador Clinpro® (ambiente seco), Grupo 2: sellador Clinpro® (ambiente húmedo), Grupo 3: sellador Embrace WetBond® (ambiente seco), Grupo 4: sellador Embrace Wet-Bond® (ambiente húmedo), Grupo 5: sellador UltraSeal XT Hydro® (ambiente seco), Grupo 6: sellador UltraSeal XT Hydro® (ambiente húmedo), Grupo 7: sellador UltraSeal XT Plus® (ambiente seco) y el Grupo 8 sellador UltraSeal XT Plus® (ambiente húmedo). Resultados: El Grupo 1 (Clinpro®/ambiente seco) Mostró valores de adhesión al esmalte superiores, de forma estadísticamente significativa, en relación a los demás grupos y mejor calidad en la formación de “tags” en comparación con los otros grupos, independientemente si el ambiente era seco o húmedo. Conclusiones: Los selladores Clinpro 3M®, utilizados en condiciones secas o de relativa humedad demostró tener buenos resultados. La resina fluida UltraSeal XT Plus® utilizada en condiciones húmedas no proporcionó buenos resultados observándose poca formación de tags; los selladores hidrófilos (Embrace Wetbond ® y UltraSeal XT Hydro®) utilizados en un ambiente húmedo tenían una capacidad de adaptación, observándose buena formación de tags; Los selladores hidrófilos usados en ambientes secos no se adaptan a la superficie y tienen una tendencia a fallar en lo que respecta a la adhesión.
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Chakraborty, Sudipta, Harshavardhan Kidiyoor, and Anand K. Patil. "Effect of Light-Curable Fluoride Varnish and Conventional Topical Fluoride Varnish on Prevention of Enamel Demineralization Adjacent to Orthodontic Brackets: A Comparative Study." Journal of Indian Orthodontic Society 54, no. 1 (January 2020): 14–23. http://dx.doi.org/10.1177/0301574219896025.

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Objectives: Various fluoride varnishes have shown promising result in preventing enamel demineralization around orthodontic brackets as they do not depend on patient compliance. The objective of the study was to compare the effect of light-curable fluoride varnish (Clinpro XT) and conventional topical fluoride varnish (Fluoritop SR) in preventing enamel demineralization adjacent to orthodontic brackets. Methods: 20 patients who required extraction of four first premolars for orthodontic treatment were bonded with orthodontic brackets and each premolar received single application of Clinpro XT and Fluoritop SR fluoride varnish in 2 diagonally opposite quadrants and rest 2 premolars acted as control. The sample teeth were debonded and extracted after 1 month and 2 months of varnish application. The samples were sectioned using hard tissue microtome and evaluated under polarized light microscopy to measure the depth of demineralization. Results: Kolmogorov Smirnov test showed normal distribution of data. Comparison between the study groups with depth of demineralization scores showed statistically significant variation in one-way analysis of variance test. Turkey’s multiple post hoc procedures showed statistically significant difference in the depth of demineralization between all the 3 groups after 1 month and 2 months. Dependent t test showed statistically significant increment in the depth of demineralization in all the 3 groups between 1 month and 2 months. Conclusion: This study concluded that single application of both Fluoritop SR and Clinpro XT was effective in reducing significant depth of demineralization compared to control. Clinpro XT showed significantly less demineralization compared to Fluoritop SR after 1 month and 2 months of varnish application.
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Leal, Taís Pereira, Ricardo Scarparo Navarro, Patrícia Moreira de Freitas, Caleb Shitsuka, Heide Mendonça Moreira de Souza, Maristela Dutra Corrêa, and Cristina Lúcia Feijó Ortolani. "Efeitos de selantes na desmineralização in vitro do esmalte ao redor dos bráquetes ortodônticos." Research, Society and Development 10, no. 11 (September 11, 2021): e560101119923. http://dx.doi.org/10.33448/rsd-v10i11.19923.

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O estudo in vitro avaliou os efeitos dos selantes CLINPRO™ XT e FLUROSHIELD® na prevenção da desmineralização no esmalte dental na região circunscrita aos bráquetes ortodônticos, através da microdureza e microscopia eletrônica de varredura. Utilizou sessenta coroas de dentes bovinos, divididas aleatoriamente nos grupos (n: 20): G1 (bráquetes /controle), G2 (bráquetes/CLINPRO™) e G3 (bráquetes/FLUROSHIELD®). As amostras foram submetidas ao desafio cariogênico (DES/RE), avaliadas a microdureza Knoop (25 g,10 s), na superfície do esmalte dental, a partir do bráquete nas distâncias de 1.000 µm, 2.000 µm e 3.000 µm e 100 µm, 200 µm, 300 µm e 400 µm na interface em profundidade, nas direções incisal e cervical. Imagens em MEV foram obtidas da superfície na região cervical. Os resultados analisados pelos testes estatísticos ANOVA e Tukey (p< 0,05), mostraram significativa influência nos valores da microdureza nas interações Tratamento/Distância e Tratamento/Distância/Região (p= 0,00) nos grupos G2 e G3 apresentaram maior microdureza do esmalte nas áreas mais próximas ao bráquete quando aplicado selante, maiores valores de microdureza com o selante CLINPRO™. Nas amostras que não receberam selante não foi observada influência dessas interações com a microdureza (p> 0,05). O selante CLINPRO™ apresentou os maiores valores de microdureza e efetividade quando comparado com os grupos controle e selante FLUROSHIELD. Concluiu-se que os selantes foram mais efetivos em prevenir a desmineralização do esmalte nas regiões mais próximas aos bráquetes e menos efetivos nas regiões mais distantes. A composição química e propriedades do selante interferem na sua ação em reduzir a desmineralização do esmalte dental.
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Allabban, Yasir. "Evaluation of dental enamel color after fixed orthodontic therapy using two types of protectors to prevent white spot lesions (A prospective clinical study)." Journal of Baghdad College of Dentistry 32, no. 2 (June 15, 2020): 17–21. http://dx.doi.org/10.26477/jbcd.v32i2.2889.

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Background: The aim of this study is to evaluate the color change ∆E of the dental enamel following treatment with 2 kinds of protector (icon infiltrant, clinpro varnish) before fixed orthodontic treatment to avoid the possible white spot lesions. Materials and Methods: Fifty four subjects treated with fixed appliances were divided into 3 groups: the 1st group was control, while the 2nd and 3rd groups were treated with icon infiltrant and clinpro varnish before bonding procedure, respectively. Color parameters (L,a,b) were recorded for the middle and gingival thirds before and after bonding procedure to get the ∆E of each group. Results: One-way ANOVA test showed a non-significant difference in ∆E between the 3 groups at p value <0.05, while there were highly significant differences in value of ∆E between middle thirds and the gingival thirds in all groups. Conclusion: The icon infiltrant and clinpro varnish have no effect on color of the enamel when used before the bonding procedure. Color change ∆E occurring in middle third is higher than that of the gingival third. Keywords: Color change, protector, white spot lesions
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Marques, Joyce Figueiredo de Lima, Laura Nobre Ferraz, Beatriz Kelly Barros Lopes, Tamires Aparecida Borges Vasconcelos, Thiely Roberts Teixeira, Débora Alves Nunes Leite Lima, Flávio Henrique Baggio Aguiar, and Diogo de Azevedo Miranda. "Assessment of influence of LED curing units used on microhardness of resin-modified glass ionomer sealants." Brazilian Journal of Oral Sciences 21 (August 22, 2022): e226202. http://dx.doi.org/10.20396/bjos.v21i00.8666202.

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Aim: Resin modified glass ionomer (RMGI) is class of material that can be used as sealant for preventing and arresting the progression of caries in pits and fissures. As these are hybrid materials, their properties can be affected by factors related to the polymerization process. Therefore, this study aimed to evaluate the influence of different generations of LED curing units (Elipar DeepCure-L and VALO Grand) on Knoop microhardness values (KHN) of RMGI sealants (Clinpro XT and Vitremer). Methods: Forty cylindrical specimens (6mm ø x 1 mm high) were prepared according to the manufacturer’s instructions and divided into four groups (n=10) according to the type of RMGI and LED used. The KHN of the top surface of each sample was calculated 7 days after light-curing. Data were submitted to two-way ANOVA (α = 0.05). Results: Vitremer had higher KHN values than Clinpro XT after using both LEDs (p<0.0001), but especially when light-cured with the use of VALO Grand (p<0.0001). Whereas the KHN value of Clinpro was not influenced by the LED device (p>0.05). Conclusions: Top surface microhardness values of RGMI sealants were affected by both material composition and generations of LED curing units used. Third generation LED curing units seemed to be more efficient for the polymerization of RMGI-based sealants.
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Nahvi, Azam, Alireza Razavian, Hoorieh Abedi, and Jamshid Yazdani Charati. "A comparison of microleakage in self-etch fissure sealants and conventional fissure sealants with total-etch or self-etch adhesive systems." European Journal of Dentistry 12, no. 02 (April 2018): 242–46. http://dx.doi.org/10.4103/ejd.ejd_63_18.

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ABSTRACT Objective: The present study was conducted to compare microleakage in self-etching fissure sealants and conventional fissure sealants with total-etch or self-etch adhesive systems. Settings and Design: This experimental in vitro study was conducted on 60 healthy third molars extracted from humans. The first group received Acid etch + Clinpro sealant, the second group received Acid etch + Single bond 2 + Clinpro sealant, the third group received Single bond universal (self-etching bonding) + Clinpro sealant, and the fourth group received prevent seal self-etching sealant. Materials and Methods: An incision was made on the teeth after they were immersed in methylene blue 5%. The samples were then examined under a stereomicroscope and the dye penetration rate was measured based on the Williams and Winter criteria. Statistical Analysis Used: The Kruskal–Wallis and Mann–Whitney tests were used for data analysis in SPSS-18 (P < 0.05). Results: Group 1 which was treated with the conventional technique (acid + fissure sealant) had the highest rate of microleakage compared to Groups 2 and 3 (P < 0.001). Conclusion: The results showed that the use of bonding results in a significant reduction in the microleakage of fissure sealants. The microleakage caused when using self-etch fissure sealant was not different from that caused by the use of the conventional method.
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Berkathullah, Marwah, Mohideen S. Farook, and Okba Mahmoud. "The Effectiveness of Remineralizing Agents on Dentinal Permeability." BioMed Research International 2018 (September 12, 2018): 1–12. http://dx.doi.org/10.1155/2018/4072815.

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The effectiveness of remineralizing agents in reducing dentine permeability by tubule occlusion using fluid filtration device functioning at 100 cmH2O (1.4 psi) pressure and SEM/EDX analysis were evaluated and compared. Seventy (n = 70) dentine discs of 1±0.2 mm width were prepared from sound permanent human molars. Fifty (n = 50) dentine discs were randomly divided into 5 groups (n = 10): Group 1: GC Tooth Mousse Plus (Recaldent GC Corporation Tokyo, Japan), Group 2: Clinpro™ White Varnish (3M ESPE, USA), Group 3: Duraphat® Varnish (Pharbil Waltrop GmbH, Germany), Group 4: Colgate Sensitive Pro-Relief™ dentifrice (Colgate Palmolive, Thailand), and Group 5: Biodentine™ (Septodont/UK). Dentine permeability was measured after treatment application at 10 minutes, artificial saliva immersion at 7 days, and citric acid challenge for 3 minutes. Data were analyzed by two-way repeated measures ANOVA. Dentine specimens (n = 20) were used for SEM/EDX analyses to obtain qualitative results on dentine morphology and surface deposits. Each treatment agent significantly reduced dentine permeability immediately after treatment application and created precipitates on treated dentine surfaces. All agents increased permeability values after 7 days of artificial saliva immersion except Clinpro White Varnish and Biodentine. Clinpro White Varnish exhibited significant resistance to acid challenge compared to others. Colgate Sensitive Pro-Relief dentifrice has a dual mechanism of action in reducing the dentine sensitivity.
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Alsubhi, Hassan, Mohammad Gabbani, Abdulsalam Alsolami, Mohammed Alosaimi, Jameel Abuljadayel, Waleed Taju, and Omair Bukhari. "A Comparison between Two Different Remineralizing Agents against White Spot Lesions: An In Vitro Study." International Journal of Dentistry 2021 (January 18, 2021): 1–5. http://dx.doi.org/10.1155/2021/6644069.

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Enamel demineralization and white-spot lesions (WSLs) around the orthodontic brackets are common clinical complications after orthodontic fixed appliance therapy. WSLs form mainly due to plaque deposition around the brackets during the orthodontic treatment period. This study was designed to compare and evaluate the efficacy of two different remineralization agents on WSLs, which are “Clinpro 5000 and Colgate Sensitive Pro-Relief”. 27 caries-free human premolar teeth were collected after extraction for orthodontic purposes. The crowns were set in acrylic resin, and the entire surfaces were coated with nail varnish apart from an area of 4 × 4 mm on the buccal surface. The surface microhardness (SMH) was measured using the Vickers microhardness testing machine at baseline, after demineralization, and after treatment. Then, the different SMH values were statistically analyzed using mixed-effects linear regression. All samples were immersed in demineralizing solution for ten days to create WSLs, and then the teeth were allocated randomly into one of the three groups: Group 1 (control group-immersed in artificial saliva), Group 2 (treated with Colgate sensitive Pro-Relief toothpaste), and Group 3 (Clinpro 5000 toothpaste). Cycles of treatment were done for 5 minutes every 12 hours for 14 days. The samples were stored in freshly prepared artificial saliva between cycles. The mixed-effects model was used to quantify the effect of different remineralization agents. All statistics were computed using STATA software (version14.1; Stata, College Station, TX). All statistical tests were two-tailed and interpreted at the 0.05 significance level. Both agents improved the surface hardness. Clinpro 5000 improved the surface hardness by 12.7 ( P value 0.012), and Colgate Sensitive Pro-Relief improved surface hardness by 18.2 ( P value <0.0001), However when both treatments are compared with each other, there was no statistical significance among them. When compared to the control group, both treatments “Clinpro™ 5000 and Colgate Sensitive Pro-Relief” have significantly improved enamel’s SMH.
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Poza-Pascual, Andrea, Clara Serna-Muñoz, Amparo Pérez-Silva, Yolanda Martínez-Beneyto, Inmaculada Cabello, and Antonio José Ortiz-Ruiz. "Effects of Fluoride and Calcium Phosphate-Based Varnishes in Children at High Risk of Tooth Decay: A Randomized Clinical Trial." International Journal of Environmental Research and Public Health 18, no. 19 (September 24, 2021): 10049. http://dx.doi.org/10.3390/ijerph181910049.

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Background: The aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, salivary pH, salivary lactic acid and chemical elements concentrations. Methods: We included 58 children aged 4–12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-month saliva samples were taken. We assessed changes in pH, lactic acid concentrations and chemical elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p = <0.001), 31P (p = 0.033) and 66Zn (p = 0.005) levels in the placebo group (p ≤ 0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F. Conclusions: Neither pH, lactic acid concentrations or most salivary chemical elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-month application for 12 months. However, the appearance of new cavities was stopped, and the hygiene index improved, probably due to hygienic and dietary measures and the use of fluoridated toothpaste. Trial registration: ISRCTN registry, ISRCTN13681286.
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Demirel, Akif, Orhan Işıl, Öz Tulga, and Kaan Orhan. "Three dimensional evaluation of marginal microleakage at the adhesive interface between different fissure sealants and enamel: Micro-CT analysis." Balkan Journal of Dental Medicine 26, no. 1 (2022): 7–14. http://dx.doi.org/10.2478/bjdm-2021-0032.

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Background/Aim: Sealing ability and adhesion to enamel of fissure sealants are quite critical in prevention of dental caries. The objective of the present study was to assess the marginal microleakage of different material-based pit and fissures with non-invasive and invasive techniques by using the Micro-CT method. Material and Methods: 30 extracted human permanent molars were randomly assigned to three sealant groups (n=10) as resin-based ClinPro, giomer-based BeautiSealant, and glass ionomer-based Fuji IX-GP. Half of each group was randomly divided into two parts as non-invasive and invasive techniques. The volumetric analysis of marginal microleakage between the enamel-material interface was performed by using Micro-CT. The results were analyzed with Student's t, One-Way ANOVA, Tukey and Games-Howell tests. Statistical significance level was considered as 0.05. Results: In non-invasive technique, Fuji IX-GP showed statistically significantly lower marginal microleakage values than Clinpro (p=0.022). Other comparisons were not significant (p>0.05). However, in invasive technique, microleakage values both of Fuji IX-GP and BeautiSealant were significantly lower than Clinpro (p<0.001, p<0.001). Besides, regardless of the sealant material, the invasive technique showed significantly superior results than non-invasive technique regarding marginal microleakage. Conclusions: Considering the clinical conditions, it was concluded that glass ionomer-based Fuji IX-GP and giomer-based BeautiSealant could be used as alternative to resin based sealants. Additionally, invasive technique (fissure preparation) can be recommended to reduce marginal microleakage.
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Demirel, Akif, Orhan Işıl, Öz Tulga, and Kaan Orhan. "Three dimensional evaluation of marginal microleakage at the adhesive interface between different fissure sealants and enamel: Micro-CT analysis." Balkan Journal of Dental Medicine 26, no. 1 (2022): 7–14. http://dx.doi.org/10.5937/bjdm2201007d.

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Background/Aim: Sealing ability and adhesion to enamel of fissure sealants are quite critical in prevention of dental caries. The objective of the present study was to assess the marginal microleakage of different material-based pit and fissures with non-invasive and invasive techniques by using the Micro-CT method. Material and Methods: 30 extracted human permanent molars were randomly assigned to three sealant groups (n=10) as resin-based ClinPro, giomer-based BeautiSealant, and glass ionomer-based Fuji IX-GP. Half of each group was randomly divided into two parts as non-invasive and invasive techniques. The volumetric analysis of marginal microleakage between the enamel-material interface was performed by using Micro-CT. The results were analyzed with Student's t, One-Way ANOVA, Tukey and Games-Howell tests. Statistical significance level was considered as 0.05. Results: In non-invasive technique, Fuji IX-GP showed statistically significantly lower marginal microleakage values than Clinpro (p=0.022). Other comparisons were not significant (p>0.05). However, in invasive technique, microleakage values both of Fuji IX-GP and BeautiSealant were significantly lower than Clinpro (p<0.001, p<0.001). Besides, regardless of the sealant material, the invasive technique showed significantly superior results than non-invasive technique regarding marginal microleakage. Conclusions: Considering the clinical conditions, it was concluded that glass ionomer-based Fuji IX-GP and giomer-based BeautiSealant could be used as alternative to resin based sealants. Additionally, invasive technique (fissure preparation) can be recommended to reduce marginal microleakage.
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Naoum, Steven J., Andrea Lenard, F. Elizabeth Martin, and Ayman Ellakwa. "Enhancing Fluoride Mediated Dentine Sensitivity Relief through Functionalised Tricalcium Phosphate Activity." International Scholarly Research Notices 2015 (April 2, 2015): 1–9. http://dx.doi.org/10.1155/2015/905019.

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Background. To assess the clinical efficacy of a dentifrice containing fluoride and functionalised tricalcium phosphate (fTCP) in reducing dentine sensitivity. Methods. A 10-week parallel blind randomised control trial was conducted. Subjects were assigned to one of four groups and instructed to brush twice daily: A: Colgate Cavity Protection (1000 ppmF-MFP); B: Sensodyne Total Care (1000 ppmF-NaF + 19300 ppmK+-KNO3); C: Clinpro Tooth Crème (950 ppmF-NaF + fTCP); and D: Clinpro Tooth Crème (brushing + additional topical application). Seventy-one patients were assessed at baseline, 6 weeks, and 10 weeks for cold, tactile, and hypertonic sensitivity using the NRS-11 pain rating scale. A combined modalities sensitivity score (CMS) was calculated. Results. At 6 weeks, patients reported the following reduction in CMS: A (20%); B (30%); C (42%); D (52%). At 10 weeks, patients reported the following reduction in CMS: A (18%), B (40%), C (24%), and D (54%). The only CMS comparisons to show a significant difference (P<0.05) were between Groups A and D (6 and 10 weeks). Conclusions. Addition of fTCP to a dentifrice enhances the ability of dentifrice fluoride in reducing dentine sensitivity. Using Clinpro Tooth Crème twice daily for brushing can be as effective to reduce dentine sensitivity as twice daily brushing using Sensodyne Total Care. However, additional nightly topical application of fTCP, in addition to twice daily brushing, showed an enhanced reduction in dentine sensitivity.
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Eyüboğlu, GB, and P. Naiboğlu. "Clinical Efficacy of Different Dentin Desensitizers." Operative Dentistry 45, no. 6 (June 9, 2020): E317—E333. http://dx.doi.org/10.2341/19-258-c.

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Clinical Relevance Teethmate Desensitizer, Clinpro White Varnish, Shield Force Plus, and Gluma could be recommended for treating dentin hypersensitivity in terms of clinical efficacy. SUMMARY Objective: The aim of this study was to evaluate the clinical efficacy of widely used dentindesensitizing agents (DDAs) (Teethmate Desensitizer, Clinpro White Varnish, Shield Force Plus, and Gluma) in the treatment of dentin hypersensitivity (DH) according to different evaluation parameters over a four-week follow-up period. Methods and Materials: This study was a randomized, single-center, controlled, parallel group study involving 144 teeth in 40 subjects. The baseline DH levels of the subjects were determined using different evaluation parameters. Daily life hypersensitivity and evaporative air stimulus hypersensitivity scores were recorded using a visual analog scale (VAS), and tactile hypersensitivity scores were recorded using a Yeaple probe and measured in grams and on the VAS. Subjects who experienced evaporative air stimulus DH (30–80 mm on the VAS) and tactile hypersensitivity (10–50 g with the Yeaple probe) were included in the study. After application of the DDAs, these evaluation parameters were recorded throughout the follow-up period (immediately after application and at one day and two and four weeks post-application). Results: All four DDAs demonstrated clinical dentin-desensitizing effects throughout the follow-up period according to evaporative air hypersensitivity, tactile sensitivity (g-VAS), and daily life hypersensitivity scores (p&lt;0.05). Only Clinpro White Varnish had tactile sensitivity (g) scores that were similar at baseline and the one-day follow-up (p&gt;0.05). A comparison of DH-reducing effects among the DDAs revealed that they yielded different results immediately after application and at the one-day follow-up time point, depending on which evaluation parameter was used. However, all DDAs showed similar DH-reducing effects at the two- and four-week follow-up time points. Conclusions: Teethmate Desensitizer, Clinpro White Varnish, Shield Force Plus, and Gluma DH showed clinical efficacy for four weeks. DDAs may produce inconsistent clinical evaluation scores not only across different evaluation parameters but also between early and later follow-up time points.
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Saravia, Marta Estela, Lea Assed Bezerra Silva, Raquel Assed Bezerra Silva, Marília Pacífico Lucisano, Andrea Uribe Echevarría, Jorge Uribe Echevarría, and Paulo Nelson-Filho. "Evaluation of Chair-Side Assays in High Microbiological Caries-Risk Subjects." Brazilian Dental Journal 26, no. 6 (December 2015): 592–95. http://dx.doi.org/10.1590/0103-6440201300389.

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The aim of this study was to evaluate the commercial chair-side assays Saliva-Check Mutans and ClinproTM Cario L-PopTM in high microbiological caries-risk dental students compared with conventional semi-quantitative colony counting culture-based technique as the reference method. Saliva samples from 93 subjects of both sexes aged 18-26 years were seeded (Köhler and Bratthall method) on plates containing SB-20M culture medium method and 12 subjects with high caries risk were selected. These 12 individuals were subjected to determination of caries risk using two commercial rapid detection chair-side assays (Saliva-Check Mutans and ClinproTM Cario L-PopTM) according to the manufacturers' instructions. The results were analyzed by the Kappa correlation test using SAS statistical software. There was a perfect agreement (Kappa=1) among the three caries risk evaluation methods - chair-side assays and semi-quantitative CFU count (control) - in all subjects. The results suggest that the commercial chair-side assays evaluated in this study may be practical and useful to identify high microbiological caries-risk subjects.
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Eyüboğlu, GB, C. Yeşilyurt, and M. Ertürk. "Evaluation of Cytotoxicity of Dentin Desensitizing Products." Operative Dentistry 40, no. 5 (September 1, 2015): 503–14. http://dx.doi.org/10.2341/13-334-l.

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SUMMARY Objectives To evaluate the cytotoxic effects of the dentin desensitizing products (DDPs) used in the treatment of dentin hypersensitivity on cultured human gingival and pulpal fibroblast cells. Methods and Materials The cytotoxic effects of DDPs (Smart Protect, Systemp Desensitizer, Seal & Protect, Aqua-Prep F, Isodan, Gluma, BisBlock, D/Sense Crystal, UltraEZ, Colgate Sensitive Pro-Relief, Topex, and Clinpro White Varnish) on cultured human gingival- and pulp-derived fibroblast cells were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test (Serva, Heidelberg, Germany) under two different conditions. In the first test, different dilutions of the DDPs were directly applied onto cultured gingival fibroblast cells, and in the second test, the products were applied onto different-thickness dentin discs (0.5 and 1 mm) placed above cell culture medium, which contained pulp fibroblast cells. Results According to the cytotoxicity evaluations of gingival fibroblast cells, the cytotoxicity of all of the DDPs was very high at 50% concentrations (p&lt;0.05). Colgate Sensitive Pro-Relief, Clinpro White Varnish, and Topex showed higher cytotoxicity than did the other products (p&lt;0.05), decreasing with further dilutions, and these products were found to be less cytotoxic to both types of cells (p&lt;0.05) than were the other products with further dilutions. The cytotoxicity to human gingival and pulpal fibroblast cells of Systemp Desensitizer, Aqua-Prep F, Isodan, and Gluma did not show any decrease with further dilutions, and these products were found to be more cytotoxic than the other products (p&lt;0.05). Conclusions According to the findings of this study, Colgate Sensitive Pro-Relief, Topex, and Clinpro White Varnish were less cytotoxic than the other DDPs used in this study.
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Minagawa, Toshiya, Kohji Sakanaka, Shin-Ichi Inaba, Yoshimichi Sai, Ikumi Tamai, Toshio Suwa, and Akira Tsuji. "Blood-brain-barrier Transport of Lipid Microspheres Containing Clinprost, a Prostaglandin I2 Analogue." Journal of Pharmacy and Pharmacology 48, no. 10 (October 1996): 1016–22. http://dx.doi.org/10.1111/j.2042-7158.1996.tb05893.x.

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Vianna, Julia Sotero, Mariana Marquezan, Thiago Chon Leon Lau, and Eduardo Franzotti Sant'Anna. "Bonding brackets on white spot lesions pretreated by means of two methods." Dental Press Journal of Orthodontics 21, no. 2 (April 2016): 39–44. http://dx.doi.org/10.1590/2177-6709.21.2.039-044.oar.

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Abstract Objective: The aim of this study was to evaluate the shear bond strength (SBS) of brackets bonded to demineralized enamel pretreated with low viscosity Icon Infiltrant resin (DMG) and glass ionomer cement (Clinpro XT Varnish, 3M Unitek) with and without aging. Methods: A total of 75 bovine enamel specimens were allocated into five groups (n = 15). Group 1 was the control group in which the enamel surface was not demineralized. In the other four groups, the surfaces were submitted to cariogenic challenge and white spot lesions were treated. Groups 2 and 3 were treated with Icon Infiltrant resin; Groups 4 and 5, with Clinpro XT Varnish. After treatment, Groups 3 and 5 were artificially aged. Brackets were bonded with Transbond XT adhesive system and SBS was evaluated by means of a universal testing machine. Statistical analysis was performed by one-way analysis of variance followed by Tukey post-hoc test. Results: All groups tested presented shear bond strengths similar to or higher than the control group. Specimens of Group 4 had significantly higher shear bond strength values (p < 0.05) than the others. Conclusion: Pretreatment of white spot lesions, with or without aging, did not decrease the SBS of brackets.
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Koudelka, Štěpán, Tereza Gelbíčová, Markéta Procházková, and Renáta Karpíšková. "Lineage and serotype identification of Listeria monocytogenes by matrix-assisted laser desorption ionization-time of flight mass spectrometry." Czech Journal of Food Sciences 36, No. 6 (January 7, 2019): 452–58. http://dx.doi.org/10.17221/87/2018-cjfs.

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The identification of Listeria species, lineages and serotypes remains a crucial issue not only in epidemic surveys, but also in monitoring of the diversity of bacteria in the food chain. The aim of this study was identification of L. monocytogenes strains at lineage and serotype level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The performance of MALDI-TOF MS was tested to identify L. monocytogenes into two lineages (I and II) and four serotypes (1/2a, 1/2b, 1/2c and 4b) the most commonly found in humans and food. Total of 227 L. monocytogenes strains from different sources were subjected to the study. Some of strains (112) were used for main spectrum profile (MSP) library creation. Other strains of interest (115) were then correctly identified on the lineage level comparing with the library by MALDI-TOF MS analysis using Biotyper (90%) and ClinPro Tools (100%) software. The serotype identification with 55.7% (Biotyper) and 67.8% (ClinPro Tools) accuracy is rather a proof that under given conditions the method has not big potential to be used for serotyping. However, MALDI-TOF MS has a potential to identify lineages of L. monocytogenes of food and human origin.
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Tarnovskaya, Svetlana I., Anna A. Kostareva, and Boris S. Zhorov. "L-Type Calcium Channel: Predicting Pathogenic/Likely Pathogenic Status for Variants of Uncertain Clinical Significance." Membranes 11, no. 8 (August 7, 2021): 599. http://dx.doi.org/10.3390/membranes11080599.

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(1) Background: Defects in gene CACNA1C, which encodes the pore-forming subunit of the human Cav1.2 channel (hCav1.2), are associated with cardiac disorders such as atrial fibrillation, long QT syndrome, conduction disorders, cardiomyopathies, and congenital heart defects. Clinical manifestations are known only for 12% of CACNA1C missense variants, which are listed in public databases. Bioinformatics approaches can be used to predict the pathogenic/likely pathogenic status for variants of uncertain clinical significance. Choosing a bioinformatics tool and pathogenicity threshold that are optimal for specific protein families increases the reliability of such predictions. (2) Methods and Results: We used databases ClinVar, Humsavar, gnomAD, and Ensembl to compose a dataset of pathogenic/likely pathogenic and benign variants of hCav1.2 and its 20 paralogues: voltage-gated sodium and calcium channels. We further tested the performance of sixteen in silico tools in predicting pathogenic variants. ClinPred demonstrated the best performance, followed by REVEL and MCap. In the subset of 309 uncharacterized variants of hCav1.2, ClinPred predicted the pathogenicity for 188 variants. Among these, 36 variants were also categorized as pathogenic/likely pathogenic in at least one paralogue of hCav1.2. (3) Conclusions: The bioinformatics tool ClinPred and the paralogue annotation method consensually predicted the pathogenic/likely pathogenic status for 36 uncharacterized variants of hCav1.2. An analogous approach can be used to classify missense variants of other calcium channels and novel variants of hCav1.2.
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Attar, Moaz H., Medhat A. Abdallah, Hussein A. Alharthy, and Omar A. El Meligy. "Effect of Bonding Agent on Retention of Different Sealants: An in Vitro Study." Journal of Clinical Pediatric Dentistry 45, no. 3 (June 30, 2021): 177–85. http://dx.doi.org/10.17796/1053-4625-45.3.6.

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Objectives: To investigate the effect of Co-curing versus Staged-curing and No-bonding on retention of different resin-based sealants (RBS). Study design: For shear bond strength (SBS) and microleakage tests, 90 extracted premolars were divided equally into 3 groups (I, II, III). Each group was further subdivided equally into 3 subgroups (a, b, c). No-bonding subgroups did not receive a bonding agent, Staged-curing subgroups received a bonding agent that was cured before sealant application, while Co-curing subgroups received a bonding agent that was cured after sealant application. Seal-it was applied for group I, Helioseal-F for group II and Clinpro for group III. SBS buttons were tested using Instron machine, while microleakage specimens were examined using micro-CT. Results: Clinpro showed the highest SBS values in Staged-curing and No-bonding groups (8.72±2.39, 12.51±3.16) respectively. Staged-curing was significantly greater in SBS values than those for other groups (P&lt;0.05). There was a significant difference in microleakage values of Staged-curing among different RBS (P = 0.003), while there was no significant difference in values of No-bonding and Co-curing among different RBS (P = 0.541, P = 0.521). Conclusions: The use of a bonding agent as Staged-curing was more effective in improving sealant retention than No-bonding and Co-curing.
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Buckshey, Sakshi, Robert P. Anthonappa, Nigel M. King, and Anut Itthagarun. "Remineralizing Potential of Clinpro® and Tooth Mousse Plus® on Artificial Carious Lesions." Journal of Clinical Pediatric Dentistry 43, no. 2 (January 1, 2019): 103–8. http://dx.doi.org/10.17796/1053-4625-43.2.6.

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Background: Calcium phosphate and fluoride (F) delivery systems claim to facilitate enamel remineralization. Aim: To evaluate and compare (i) the remineralizing potential of Clinpro® Tooth Crème(CTC) and Tooth Mousse Plus®(TMP) on artificial carious lesions, and (ii) the benefit of 1000ppm F dentifrice prior to the application of CTC and TMP. Study design: Carious lesions, 200–300μm deep were produced by placing molars in demineralizing solution for 96h, sections 100–150μm thick were then randomly assigned to six groups(n=150). Specimens were treated thrice daily with a non-fluoridated(Group A), or fluoridated dentifrice[1000ppm, (Group B)], or CTC(Group C), TMP(Group D), fluoridated dentifrice followed by CTC(Group E), or a fluoridated dentifrice followed by TMP(Group F), and then subjected to a 10-day pH cycling model. Lesion evaluation involved polarizing light microscopy and microradiography. Results: Posttreatment maximum mineral content at the surface zone(Vmax) was significantly increased in Groups B, C, and D compared to the other groups. The lesion depth(LD) decreased in Group D&gt;Group C&gt;Group E, and the net mineral content gain(ΔZ) in Group C&gt;Group D, which did not reach statistical significance. Conclusions: CTC and TMP exhibited similar efficacy in remineralizing artificial carious lesions. Nevertheless, the net mineral gain or lesion consolidation following CTC use was higher than TMP.
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Noenko, I. V., O. V. Pavlenko, and Yu O. Mochalov. "Study of The Adhesion Strength of Photocomposite Enamel Sealants to the Tooth Surface." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 8, no. 1 (February 27, 2023): 171–76. http://dx.doi.org/10.26693/jmbs08.01.171.

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The purpose of the study was to compare an adhesion strength of some modern enamel sealants to the enamel of a developing tooth which occurs without adhesive preparation of tooth surface. Materials and methods. In laboratory the shear adhesion strength to human teeth enamel without adhesive system application was compared for “Fissurit FX” (VOCO), “Clinpro™ Sealant” (3M™ ESPE™) and “Jen-Fissufil” (Jendental-Ukraine LLC). 30 samples were tested on tensometric system. Tests were performed according to requirements of ISO 4049:2019 “Dentistry – Polymer-based restorative materials” and ISO 6874:2005 “Dentistry – Polymer-based pit and fissure sealants”. Results and discussion. Performed experimental studies of sealant adhesion (without the use of adhesive systems, only with acid etching) showed that it was the largest in the domestic “Jen-Fissufil” – 9.80 ± 1.17 MPa (M=10.42 MPa, min – 7.41 MPa, max – 11.07 MPa); less in “Fissurit FX” – 9.78 ± 1.33 MPa (M=9.43 MPa, min – 8.23 MPa, max – 12.62 MPa) and “Clinpro™ Sealant” – 9.55 ± 1.88 MPa (М=8.69 MPa, min – 6.35 MPa, and max – 14.73 MPa). The performed statistical tests did not reveal any significant differences between the adhesion strength in all three subgroups. Due to the changes in the concept of dental caries development and approaches to its control that have taken place in dentistry over the past 30 years, the role of enamel sealants in achieving caries control in individual and communal prevention of dental diseases has significantly increased. The tendency to expand the indications for the use of photocomposite enamel sealants in clinical practice is also worth noting. In addition to their direct purpose, the materials can be used for “repair” and restoration of individual photocomposite fillings with minor wear and used as a lining material for the restoration of teeth with carious cavities with a high C-factor. Conclusion. In modern dentistry the use of enamel photocomposite sealants is one of the most effective and reliable methods of preventing caries of the occlusal surfaces of teeth. The study of shear adhesion to acid-etched enamel for photocomposite materials “Fissurit FX”, “Clinpro™ Sealant” and “Jen-Fissufil” did not reveal any significant differences. The technology of composite tooth enamel sealants is currently successful in clinical practice and continues to improve and develop. The development of new and quality improvement of such materials is an urgent issue for science and technology
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Spaičytė, Nerija, Ieva Gudelevičiūtė, Indrė Migonienė, and Arūnas Vasiliauskas. "INTERVENTIONS PRIOR AND DURING THE ORTHODONTIC TREATMENT FOR ORTHODONTICALLY INDUCED WHITE SPOT LESIONS." Health Sciences 33, no. 1 (January 1, 2023): 166–74. http://dx.doi.org/10.35988/sm-hs.2023.041.

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Objective. To evaluate the efficiency of various interven­tions performed before and during orthodontic treatment which aim to reduce the incidence of WSL. Materials and methods. Using PRISMA guidelines in search of clinical trials published between 2017 and 2022, a literature analysis was performed. This search was conducted using following Medical Subject Heading (MeSH) terms in 2 databases: “prevention and control” AND “Orthodontics” AND “Tooth Demineralization”. Supplementary, a manual search was conducted in Go­ogle Scholar. Results. The literature search resulted in a total of 3626 study articles, of which 8 publications were used in the present review, according to a selection based on the pre-established eligibility criteria. The review showed that F varnish, 10% Xylitol varnish had positive outcomes in comparison with placebo. 0.44% APF formulated daily oral rinse and nanosilver mouthwash were better than 0.2% NaF weekly rinse and CHX, F mouthwashes res­pectively. NovaMin toothpaste, MIPP and MIV, exami­ned in different studies, proved no significant difference over regular F toothpaste. MIV compared to ProSeal provided no statistically significant between-group diffe­rences as well. Clinpro 5000 provided superior protection against enamel decalcification when compared to Clinpro Tooth Creme and MI Paste. Conclusion. The white spot lesions have improved, re­gressed, or eliminated with topical agents including F, Xylitol, or CPP-ACP during the fixed orthodontic treat­ment. In order to determine the most effective therapeu­tic approach for the treatment of surface and subsurface demineralization of the enamel, more research is needed to provide scientific proof.
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Терехова, Т. Н., А. В. Бутвиловский, О. В. Зеленевская, and Д. Л. Володкевич. "Evaluation of a Number of Properties of Glass Ionomer Cements of Chemical, Double and Triple Curing by Dentistsof the Republic of Belarus." Стоматология. Эстетика. Инновации, no. 2 (September 8, 2020): 132–42. http://dx.doi.org/10.34883/pi.2020.4.2.002.

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Введение. Стеклоиономерные цементы (СИЦ) являются широко используемой группой материалов в ежедневной стоматологической практике. В настоящее время отсутствуют данные об оценке свойств СИЦ стоматологами Беларуси, что и обуславливает актуальность данного исследования.Цель исследования. Проанализировать оценку ряда свойств СИЦ химического, двойного и тройного отверждения врачами-стоматологами Республики Беларусь.Материалы и методы. В ходе исследования 30 врачам-стоматологам было предложено оценить 8 свойств 6 СИЦ: 3 классических, 2 двойного отверждения и 1 тройного отверждения. Название материала в процессе замешивания (в пропорциях, рекомендованных производителем) и внесения врачам было неизвестно. Оценка проводилась по 10-балльной шкале по каждому материалу по основным манипуляционным свойствам (легкость замешивания, консистенция, отсутствие прилипаемости к инструменту, легкость внесения и время схватывания), основным эстетическим свойствам (цвет и прозрачность) и краевой адаптации.Результаты и обсуждение. Установлены статистически значимые различия оценки врачами-стоматологами изучаемых СИЦ по всем критериям сравнения (Н≥16,85; р<0,01). Оценка стоматологами легкости замешивания СИЦ двойного отверждения «ClinPro XT Varvish», получившего максимальный балл (10 [9,5; 10]), достоверно отличалась от всех материалов кроме «Vitrebond» и «Ketac Molar EasyMix». По данному критерию материалы «Цемион» и «Ketac Universal» достоверно отличались от других исследуемых СИЦ. По мнению респондентов, лучшими эстетическими свойствами по критерию «прозрачность» (р<ркрит) обладают моди-фицированные полимером СИЦ «ClinPro XT Varvish», «Vitrebond» и «Vitremer». По критерию«цвет» все модифицированные СИЦ достоверно (р<ркрит) отличаются от материалов «Цемион» и «Ketac Universal».Заключение. Проведенное исследование позволило субъективно охарактеризовать ряд свойств СИЦ химического, двойного и тройного отверждения врачами-стоматологами Республики Беларусь и установить корреляционные взаимосвязи между отдельными свойствами. Glass ionomer cements (GICs) are a widely used group of materials in daily dental practice. Currently, there are no data on the evaluation of the properties of GICs by dentists of Belarus that determines the relevance of this research.The Purpose of the study: to analyze the assessment of a number of properties of chemical, dual- cure and tri-cure GICs by dentists of the Republic of Belarus.Materials and methods. During the research, 30 dentists were asked to evaluate 8 properties of 6 GICs materials: 3 classical, 2 dual-cure and 1 tri-cure. The name of the material during the mixing process (in the proportions recommended by the manufacturer) and during application was unknown to the doctors. The assessment was carried out on a 10-point scale for each material according to the main handling properties (ease of mixing, consistency, lack of adhesion to the instrument, ease of application and setting time), basic aesthetic properties (color and transparency) and edge adaptation.Results and discussion. Statistically significant differences of the studied GICs were assessed by the dentists according to all comparison criteria (H≥16.85; p<0.01). Evaluation by dentists of the ease of mixing the dual-cure GIC "ClinPro XT Varvish", which received the maximum score (10 [9.5; 10]), was significantly different from all materials except "Vitrebond" and "Ketac Molar EasyMix". According to this criterion, the materials "Cemion" and "Ketac Universal" differed significantly from other studied GICs. According to the respondents opinion, the best aesthetic properties according to the criterion of "transparency" (p<рcrit) are inherent to resin modified GICs "ClinPro XT Varvish", "Vitrebond" and"Vitremer". According to the criterion of "color", all resin modified GICs significantly (p<pcrit) differfrom the materials "Cemion" and "Ketac Universal".Conclusion. The research made it possible to subjectively characterize a number of properties of chemical, dual-cure and tri-cure GICs by dentists of the Republic of Belarus and establish correlation relationships between individual properties.
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Alirezaie, Najmeh, Kristin D. Kernohan, Taila Hartley, Jacek Majewski, and Toby Dylan Hocking. "ClinPred: Prediction Tool to Identify Disease-Relevant Nonsynonymous Single-Nucleotide Variants." American Journal of Human Genetics 103, no. 4 (October 2018): 474–83. http://dx.doi.org/10.1016/j.ajhg.2018.08.005.

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Soares, Ana Daniela, Joana Leonor Pereira, Sara Rosa, Maria Teresa Xavier, and Ana Luisa Costa. "C-14. AVALIAÇÃO DO RISCO DE CÁRIE COM CLINPRO CARIO-L-POP® – CASO CLÍNICO." Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial 53 (2012): e23. http://dx.doi.org/10.1016/s1646-2890(12)60061-2.

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Gerardu, Veronique, Muriel Heijnsbroek, Mark Buijs, Fridus van der Weijden, Bob ten Cate, and Cor van Loveren. "Comparison of Clinpro Cario L-Pop estimates with CIA lactic acid estimates of the oral microflora." European Journal of Oral Sciences 114, no. 2 (April 2006): 128–32. http://dx.doi.org/10.1111/j.1600-0722.2006.00345.x.

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