Relevant bibliographies by topics / Clinical Sciences not elsewhere classified

Academic literature on the topic 'Clinical Sciences not elsewhere classified'

Author: Grafiati
Published: 4 June 2021
Last updated: 19 February 2023

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Journal articles on the topic "Clinical Sciences not elsewhere classified"

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Ridgway, Jessica P., Jessica Schmitt, Ellen Almirol, Monique Millington, Erika Harding, and David Pitrak. "Electronic data sharing between public health department and clinical providers improves accuracy of HIV retention data." Open Forum Infectious Diseases 4, suppl_1 (2017): S421—S422. http://dx.doi.org/10.1093/ofid/ofx163.1059.

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Abstract Background Retention in care is critical for treatment and prevention of HIV. Many HIV care clinics measure retention rate, but data are often incomplete for patients who are classified as lost to follow-up but may be actually in care elsewhere, moved, or died. The Data to Care (D2C) initiative supports data sharing between health departments and HIV providers to confirm patient care status and facilitate reengagement efforts for out of care HIV patients. Methods The University of Chicago Medicine (UCM) provided an electronic list to the Chicago Department of Public Health (CDPH) of adult HIV-positive patients whose retention status was not certain. Retention in care was defined as at least 2 visits >90 days apart within the prior 12 months. CDPH matched this list of patients with data from the Chicago electronic HIV surveillance database. Matches were based on patient name, including alternative spellings and phonetics, and birth date. CDPH also cross-checked patient names with the CDC’s national enhanced HIV-AIDS Reporting System (eHARS) database. CDPH provided UCM with patient current care status, i.e., patient was in care elsewhere (as verified by lab data), moved out of state, or deceased. Results 780 HIV-positive patients received care in the UCM adult HIV clinic from January 1, 2013 to March 31, 2017. Of these, 360 were retained in care as of March 2017. We shared data with CDPH for 492 patients. Of these, 294 (59.8%) were matched, and 168 (34.1%) had a date of last medical care provided. See Table 1 for patient dispositions, before and after data sharing. 24 (13.4%) of patients believed to be lost to follow up according to UCM records were confirmed either transferred care or deceased according to health department data. Conclusion Data sharing between the health department and HIV providers can improve data accuracy regarding retention in care among people living with HIV. Disclosures J. P. Ridgway, Gilead FOCUS: Grant Investigator, Grant recipient; D. Pitrak, Gilead Sciences FOCUS: Grant Investigator, Grant recipient
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M, Logaraj, Sathiyanarayanan S, and Balaji R. "SYMPTOMATOLOGY OF FEMALE PATIENTS ATTENDING MOBILE MEDICAL CLINICS IN A RURAL BLOCK IN TAMILNADU." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (October 7, 2018): 172. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.20585.

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Objectives: The objectives of the study were to find out the prevalence of “symptoms not elsewhere classified” under the International Classification of Diseases, Tenth Revision, Clinical Modification among the female patients attending mobile medical clinics.Methods: A cross-sectional study was carried out among 7,124 female patients who attended weekly mobile medical clinics in a rural block in Tamil Nadu. Sociodemographic variables, symptomatology, patient history, and clinical examination details were collected using a pre-tested structured questionnaire.Results: The five common symptoms affecting the study population were myalgia (18.3%), nasal congestion (13.6%), headache (13.1%), lumbar pain (12.5%), and knee pain (9.3%). The systems commonly affected among the female patients were in the order of general symptoms and signs (R50-R69), circulatory and respiratory systems (R00-R09), and Nervous and Musculoskeletal Systems (R25-R29). In the age group of 10–19 years and 20–39 years, the most common symptom was headache (25.2% and 18.8%, respectively). In the age group of 40–59 years and 60 years and above, it was myalgia (24.2% and 32.3%, respectively).Conclusion: As pain being most common symptoms, an appropriate strategy and guidelines have to be developed to manage the problem of pain at primary care level.
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Noguera, Patricia, Campbell Pert, Catherine Collins, Nichola Still, and David Bruno. "Quantification and distribution ofAnisakis simplexsensu stricto in wild, one sea winter Atlantic salmon,Salmo salar, returning to Scottish rivers." Journal of the Marine Biological Association of the United Kingdom 95, no. 2 (October 7, 2014): 391–99. http://dx.doi.org/10.1017/s0025315414001374.

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Red vent syndrome (RVS) has previously been reported in returning wild Atlantic salmon,Salmo salarfrom Canada, Iceland, Ireland, Norway and the UK. Affected fish show reddening and swelling in the perianal/vent area, with scale loss, ulceration and bleeding in severe cases. Studies in the UK and elsewhere report the condition to be induced byAnisakis simplexsensu stricto (s.s.) larvae. This parasite, commonly reported in several marine fish species, is typically found in the body cavity and the skeletal muscle, but has recently been reported within the vent tissues of salmon. This latter finding may reflect greater efforts in examining this body portion due to current awareness of the parasite presence in this atypical location. Based on clinical observations, affected fish are classified into three categories according to the severity of the external lesions, but quantification of the vent parasite numbers in relation to the categories, and assessment of the relative importance of this area as a site of infestation, are missing to date. This investigation aimed to provide data on parasite number and distribution in the viscera, skeletal muscle, peduncle and vent area and to confirm the identity of the larvae found in the vent and the viscera. The study showed the perianal/vent region harbours the highest total number ofA. simplexlarvae per fish and, proportionally to fish biomass, is the most heavily infested body location irrespective of external severity levels of RVS.
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Atrash, Shebli, Qing Zhang, Xenofon Papanikolaou, Christoph Heuck, Aziz Bakhous, Jameel Muzaffar, Al-Ola Abdallah, and Bart Barlogie. "Characteristics and Prognosis Of IgM Multiple Myeloma." Blood 122, no. 21 (November 15, 2013): 1881. http://dx.doi.org/10.1182/blood.v122.21.1881.1881.

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Abstract Introduction Multiple Myeloma (MM) is considered a malignancy of post germinal center long-lived plasma cells. Nevertheless T-cell independent antigen stimulation before the exposure of the B-cell to the germinal center can happen and results to IgM secreting short lived plasma cells and lymphoplasmacytes representing thus a potential alternative normal counterpart for IgM plasma cell dyscrasias. IgM myeloma is an infrequent subtytpe of MM with an estimated prevalence of 0.5%. Due to its rarity little is known about its characteristics and prognosis in comparison with Waldestrom’s macroglobulinemia (WM) and the other MM subtypes. Purpose To identify the characteristics and the prognosis of IgM MM, and compare it predominantly with WM and subsequently with the rest of the MM subtypes. Methods We interogatted our Multiple Myeloma Data Base for cases of IgM MM and their respective Overall Survival (OS), Progression Free Survival (PFS), bone disease as defined by x-Rays, PET-CT and MRI, Gene Expression Profile (GEP), and common disease characteristics (anemia,calcium, creatinine) and compare it to the prognosis of WM and non-IgM MM. Diagnosis was based on the morphological and immunophenotypical findings of pathologically examined biopsy specimens along with the presence or not of typical clinical characteristics of MM (lytic bone lesions, hypercalcemia, renal failure) or typical clinical characteristics of WM (organomegaly, lymphadenopathy). Results There were 22 confirmed IgM MM cases. 14 of them presented at MIRT at initial diagnosis while 8 had previously been treated elsewhere. Osteolytic bone lesions and/or pathological fractures by x-ray and CT examination were evident in 16 cases. For the remaining 6 cases active bone focal lesions by either MRI or PET were identified in three. There was no organomegaly evident in cases with an available PET/CT at baseline, while only one had evidence of hilar and mediastinal lymphadenopathy along with calcified lung nodules. Elevated creatinine levels (>2.0 mg/dl) were evident in 4 cases at initial diagnosis. Their disease characteristics are depicted in the table 1. Median OS for IgM MM was 4.9 years while PFS could not be accurately estimated due to lack of data on patients treated elsewhere. Median OS for a historical control of 158 WM cases in MIRT was 9.2 years (Clin Lymphoma Myeloma Leuk. 11(1):139-42). Median OS of the WM group remained largely unaffected, even when the subgroup of the WM cases requiring treatment was analyzed (9.0 years).To further clarify if the IgM MM differs in terms of OS from the other isotypes of MM, we compared the IgM group to a group of 61 non-IgM MM cases which were matched by important prognostic clinical factors (age, creatinine> 2mg/dl, LDH>190u/L, b-2M >5.5mg/dl and Albumin<3.5gr/dl). No statistical difference was found for OS (p=0.846). Out of 22 cases, 14 of them had available GEP data on initial diagnosis. In 6 of these cases the cyclin D1 gene expression was high enough to be consistent with a t(11;14) translocation at FISH analysis, one case was consistent with a t(14;16) translocation, one with a t(4;14) translocation and two more were classified as belonging to the hyperdiploid subgroup. A comparative genomic analysis was performed on the IgM MM, the non-IgM MM and WM cases with available GEP data at initial diagnosis (14, 61 and 42 cases respectively). 1155 probesets that had expression level significantly different between WM and non IgM MM (FDR<3E-06) were identified. Then, the expression values of these 1155 probesets in all GEP samples, including WM, non IgM MM, and IgM MM, were used to build a clustering tree. We found that IgM MM mainly clustered with non IgM MM, supporting the findings of the clinical data. Conclusion IgM MM is a discrete clinical entity that should be distinguished from WM. Bone disease is evident in the majority of the cases, especially when specialized radiological techniques are incorporated at the initial work up. It holds a distinct prognosis from WM, while when balanced for prognostic factors that hold importance in MM it does not differ from the other MM isotypes. Finally analysis of the genetic data further supports the resemblance between IgM MM and the non IgM MM, and the difference with WM. Disclosures: Zhang: University of Arkansas for Medical Sciences: Co-inventor of the DNA probes for FISH of IGHC/IGHV (14q32), MMSET/FGFR3 (4p16), CCND3 (6p21), CCND1 (11q13), MAF (16q23), and MAFB (20q12) loci, sub. to the US Patent & Trademark Office as Prov. App# 61/726,327: Methods of Detecting 14q32 Translocations, Co-inventor of the DNA probes for FISH of IGHC/IGHV (14q32), MMSET/FGFR3 (4p16), CCND3 (6p21), CCND1 (11q13), MAF (16q23), and MAFB (20q12) loci, sub. to the US Patent & Trademark Office as Prov. App# 61/726,327: Methods of Detecting 14q32 Translocations Patents & Royalties.
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Burford, C., R. Laxton, Z. Sidhu, M. Aizpurua, A. King, I. Bodi, K. Ashkan, and S. Al-Sarraj. "ATRX immunohistochemistry can help refine ‘not elsewhere classified’ categorisation for grade II/III gliomas." British Journal of Neurosurgery 33, no. 5 (April 24, 2019): 536–40. http://dx.doi.org/10.1080/02688697.2019.1600657.

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Louis, David N., Pieter Wesseling, Werner Paulus, Caterina Giannini, Tracy T. Batchelor, J. Gregory Cairncross, David Capper, et al. "cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC)." Acta Neuropathologica 135, no. 3 (January 25, 2018): 481–84. http://dx.doi.org/10.1007/s00401-018-1808-0.

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Gangadhar, K., and D. Santhosh. "Primary Skull Osteosarcoma: MDCT Evaluation and Histopathological Correlation in Two Cases." Neuroradiology Journal 25, no. 2 (April 2012): 188–92. http://dx.doi.org/10.1177/197140091202500206.

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Osteosarcomas are typically long bone tumors and rarely affect the skull, with most articles reporting single cases. As elsewhere in the body, these lesions may be classified as primary or secondary, chiefly post-Paget and post-radiation therapy. We describe two cases of primary osteosarcoma of skull one presenting with cerebellar symptoms and another with giant skull swelling. Complete evaluation with 64 slice CT and histopathological correlation was carried out.
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WALTON, JOHN K., and DAVID TIDSWELL. "‘Classified at random by veritable illiterates’: the taking of the Spanish census of 1920 in Guipúzcoa province." Continuity and Change 20, no. 2 (August 2005): 287–313. http://dx.doi.org/10.1017/s0268416005005503.

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This article offers an approach through administrative and cultural history to the problems associated with gathering and processing data for the Spanish national census of 1920, and by implication for earlier Spanish censuses. It focuses on the Basque province of Guipúzcoa, making use of correspondence between the central statistical office in Madrid, the provincial jefe de estadística and the localities, and of reports on three problematic towns within the province. The issues that emerge regarding ‘undercounting’, the definition of administrative boundaries and the classification of demographic characteristics are set in the wider context of census-taking practices and problems elsewhere in Spain and in other cultures.
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Makino, Yasuhide, Takeshi Kawauchi, Yoshiki Arakawa, Tomoko Shofuda, Ema Yoshioka, Masahiro Tanji, Yohei Mineharu, Yonehiro Kanemura, and Susumu Miyamoto. "LGG-38. GENETIC ANALYSIS OF NEUROEPITHELIAL TUMORS IN THE PEDIATRIC AND ADOLESCENT AND YOUNG ADULT AGE IN A SINGLE INSTITUTE." Neuro-Oncology 22, Supplement_3 (December 1, 2020): iii373—iii374. http://dx.doi.org/10.1093/neuonc/noaa222.419.

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Abstract Molecular diagnosis in brain tumors has been widely spread after the publication of WHO 2016 classification. But it become a major problem that there are some tumors not to be classified on its criteria, especially in pediatric neuroepithelial tumors. To clarify the characteristics of gliomas in pediatric and adolescent and young adult age (AYA), we picked up 131 neuroepithelial tumors under 30-year-old at Kyoto University and analyze their molecular profiles. Hot spot mutations in IDH1/2, H3F3A, HIST1H3B, TERT promoter, and BRAF were analyzed by Sanger sequencing, and 1p/19q codeletion was examined by FISH or MLPA. With the pathohistological diagnosis and genetic information, all tumors were classified based on WHO 2016 classification. The terms “not otherwise specified” (NOS) and “not elsewhere classified” (NEC) were used based on cIMPACT-NOW. There were 25 glioblastomas and 34 pilocytic astrocytomas, which accounted for a larger percentage than in adult tumors. IDH-wild type gliomas accounted for 55% in diffuse astrocytomas and 69% in anaplastic astrocytomas. The percentages of gliomas with NEC were 50% of oligodendrogliomas and 20% in anaplastic oligodendrogliomas, respectively. Most pilocytic astrocytomas were under 20-year-old (27 patients) and located in infratentorial area (21 patients). Based on WHO 2016 classification, not a few neuroepithelial tumors in pediatric and AYA ages could be classified clearly. These tumors had more different genetic abnormalities than those in adult. Therefore, it may be important to evaluate these tumors with comprehensive genetic analysis.
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Fountoulakis, Konstantinos N. "The Contemporary Face of Bipolar Illness: Complex Diagnostic and Therapeutic Challenges." CNS Spectrums 13, no. 9 (September 2008): 763–79. http://dx.doi.org/10.1017/s1092852900013894.

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AbstractManic depression, or bipolar disorder, is a multifaceted illness with an inevitably complex treatment. The current article summarizes the current status of our knowledge and practice concerning its diagnosis and treatment. While the prototypic clinical picture concerns the “classic” bipolar disorder, today mixed episodes with incomplete recovery and significant psychosocial impairment are more frequent. The clinical picture of these mixed episodes is variable, eludes contemporary classification systems, and possibly includes a constellation of mental syndromes currently classified elsewhere. Treatment includes the careful combination of lithium, antiepileptics, atypical antipsychotics, and antidepressants, but not all of the agents in these broad categories are effective for the treatment of bipolar disorder.
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Dissertations / Theses on the topic "Clinical Sciences not elsewhere classified"

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Su, QingLang. "Automatic image alignment for clinical evaluation of patient setup errors in radiotherapy." Thesis, University of Central Lancashire, 2004. http://clok.uclan.ac.uk/20692/.

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In radiotherapy, the treatment is typically pursued by irradiating the patient with high energy x-ray beams conformed to the shape of the tumour from multiple directions. Rather than administering the total dose in one session, the dose is often delivered in twenty to thirty sessions. For each session several settings must be reproduced precisely (treatment setup). These settings include machine setup, such as energy, direction, size and shape of the radiation beams as well as patient setup, such as position and orientation of the patient relative to the beams. An inaccurate setup may result in not only recurrence of the tumour but also medical complications. The aim of the project is to develop a novel image processing system to enable fast and accurate evaluation of patient setup errors in radiotherapy by automatic detection and alignment of anatomical features in images acquired during treatment simulation and treatment delivery. By combining various image processing and mathematical techniques, the thesis presents the successful development of an effective approach which includes detection and separation of collimation features for establishment of image correspondence, region based image alignment based on local mutual information, and application of the least-squares method for exhaustive validation to reject outliers and for estimation of global optimum alignment. A complete software tool was developed and clinical validation was performed using both phantom and real radiotherapy images. For the former, the alignment accuracy is shown to be within 0.06 cm for translation and 1.14 degrees for rotation. More significantly, the translation is within the ±0.1 cm machine setup tolerance and the setup rotation can vary between ±1 degree. For the latter, the alignment was consistently found to be similar or better than those based on manual methods. Therefore, a good basis is formed for consistent, fast and reliable evaluation of patient setup errors in radiotherapy.
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Tam, B. K. Y. "A novel actuated digit with tactile feedback for clinical applications." Thesis, Aston University, 2006. http://publications.aston.ac.uk/12247/.

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This thesis describes the work carried out on the development of a novel digit actuator system with tactile perception feedback to a user and demonstrated as a master-slave system. For the tactile surface of the digit, contrasting sensor elements of resistive strain gauges and optical fibre Bragg grating sensors were evaluated. A distributive tactile sensing system consisting of optimised neural networking schemes was developed, resulting in taxonomy of artificial touch. The device is suitable for use in minimal invasive surgical (MIS) procedures as a steerable tip and a digit constructed wholly from polymers makes it suitable for use in Magnetic Resonance Imaging (MRI) environments enabling active monitoring of the patient during a procedure. To provide a realistic template of the work the research responded to the needs of two contrasting procedures: palpation of the prostate and endotracheal intubation in anaesthesia where the application of touch sense can significantly assist navigation. The performance of the approach was demonstrated with an experimental digit constructed for use in the laboratory in phantom trials. The phantom unit was developed to resemble facets of the clinical applications and digit system is able to evaluate reactive force distributions acting over the surface of the digit as well as different descriptions of contact and motion relative to the surface of the lumen. Completing control of the digit is via an instrumented glove, such that the digit actuates in sympathy with finger gesture and tactile information feedback is achieved by a combination of the tactile and visual means.
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Faki, Hajira. "The development and evaluation of photo-antimicrobial isoalloxazine dyes towards infection control." Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/23986/.

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In today’s world, antimicrobial resistance is one of the biggest global health issues that mankind is facing. This most effective way to ensure a wound does not become infected is through cleanliness and continued disinfection of the wound site. There is a lack of new antimicrobial drugs coming to the market due to economical and clinical reasons, this is evident in Lord O’Neill’s 2016 report and is addressed by Professor Dame Sally Davies in Parliament, (“We have reached a critical point and must act now on a global scale to slow down antimicrobial resistance”2). Prescription drugs have led to this epidemic that was highlighted by O’Neill. The latest report (2016) by O’Neill states, it is critical to improve sanitation and hygiene, refrain from overusing antibiotics in agriculture and the environment as well as introducing rapid diagnostics and vaccines3. This is leading to the need for photodynamic antimicrobial chemotherapy (PACT) that involves the use of a reactive oxygen species (ROS), photosensitiser, and light to cause microbial death. PACT is a treatment for resistant and non-resistant pathogens that is included in the treatment of multidrug resistant infections. The approach is to use novel antimicrobial drugs topically, avoiding systemic photo-toxicity, thus leading itself towards topical infection control. Herein, we report the development of a range of novel photosensitisers based on the second generation photodynamic therapeutic dyes (PDT) that are based on the tricyclic isoalloxazine structure of riboflavin, vitamin B2. Photosensitisers were synthesised using similar strategies to the isoalloxazine for a number of reasons: e.g. photoactivity and capability of degradation. In order to investigate which photosensitisers gave the highest reactive oxygen yield, functional group changes were made on the N-phenyl ring by substituting a range of electron withdrawing/donating substituents at different positions (ortho, meta, para). The free amide moiety was used to attach the photosensitiser to a solid support that would act as proof of principal of a photosensitiser attached to a bandage. These dyes show a phototherapeutic response via a Type I and II mechanism upon illumination by light of a selected wavelength. The mechanisms produce highly toxic oxygen-species, such as radical production via Type I pathway and singlet oxygen generation by Type II, thus causing terminal damage to microbes in a short time period. The synthesised photosensitisers are illuminated using blue light (440 - 490 nm) and white light in order to monitor and compare the singlet oxygen and radical yields generated as they absorb approximately at 440 nm, thus blue light being ideal for irradiation. The outstanding singlet oxygen result generated by compound 12c of 172% and a radical production by 11c of 227% show promising generators of cytotoxic species, resulting in microbial death. The synthesised photosensitisers have been tested against two opportunistic microbes (Gram positive and Gram negative bacteria; Staphylococcus aureus (S. aureus), and Escherichia coli (E.coli). They have proven to be problematic from its presence within the healthcare system especially when found on surgical site infections. From the statistics generated for the National Health Service (NHS) in the UK we can see that 52.4 % of S. aureus, and 43.1 % E.coli originates within the hospital environment. Antimicrobial activity was observed for several compounds under different light regimes on and off the solid support. As a result, the best observed MIC value of 0.25 mM/mL was achieved for S. aureus in darkness and in blue light without the polymer support. Additionally, when these compounds were linked to a polymer support (mimicking a bandage), antimicrobial activity was retained when irradiated using blue light at 1.0 mM/mL. These results show potential towards the next generation of antimicrobial disinfection agents. In time, these compounds could be integrated into the healthcare system for use as a new generation of self- cleaning bandages towards post-operative wound disinfection rather than employing front line antimicrobials. This is a moot subject under review in parliament and former UK prime minister has highlighted the concern. In a statement recently released, he states “If we fail to act, we are looking at an almost unthinkable scenario where antibiotics no longer work and we are cast back into the dark ages of medicine" – David Cameron, UK Prime Minister2.
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(10145597), Kevin J. Botsman. "An expert system as a clinical aid in the administration and dosage adjustment of some commonly prescribed therapeutic drugs and antibiotics." Thesis, 1995. https://figshare.com/articles/thesis/An_expert_system_as_a_clinical_aid_in_the_administration_and_dosage_adjustment_of_some_commonly_prescribed_therapeutic_drugs_and_antibiotics/13420277.

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Project investigates the design requirements of a computer based drug dosing system suitable for use by general physicians.. One area of medicine in which knowledge-based systems may improve day to day patient care is in the design of initial dosing regimens and dosage adjustment of certain drugs whose plasma levels correlate with their toxicity and/or efficacy. Since the general clinician is responsible for the appropriate administration of many of these drugs, a way must be found to enable these clinicians to rapidly detrmine the appropriate dose or dosage adjustment required to achieve the desired plasma concentration and thus the desired clinical effect. To obtain the best results, a good knowledge of pharrnacokinetic principles is required as well as the facility to apply these principles easily and safely. In this study, the intention was to construct a knowledge-based system for the design of drug dosing regimens and to investigate issues relating to the design of such a system which will affect its' utility in general medicine. A multidisciplinary approach to the problem was adopted. A combination of standard pharmacokinetic modelling and artificial intelligence techniques was used to design a system suitable for use by the general physician. The approach was informed by ethnography with the design incorporating features seen as desirable by prospective users and a knowledge base with facts and rules related to the safe and effective use of the system. In addition, a more general method of pharmacokinetic parameter estimation than that employed in most current pharmacokinetic systems was investigated. In the clinical environment, there are a number of sources of error which may invalidate pharmacokinetic calculations. The most important of these being those associated with the incorrect preparation of doses and the recording of incorrect times of dosing and specimen collection. It was observed that current pharmacokinetic systems do not address these sources of error directly. A more general Bayesian approach which might be extended to incorporate these 'external' errors would be appropriate. The method investigated in the report is a Bayesian formulation of the Kalman filter. It was applied to the one and two compartment linear models and to the one compartment nonlinear model. These models being sufficient to cover the majority of drugs of interest in the general hospital setting. Kalman filtering is a general method for handling state-space models which gives optimal estimates of the current state of a dynamic system. It is commonly encountered in the field of control engineering but is also used in the analysis of time series. The method was shown to be adaptable in principle to pharmacokinetic parameter estimation and it is theoretically extendable to incorporate the external sources of error described above. The positive initial results presented in the report form the basis for ongoing research into the possible extension of the system and a formal assessment of user acceptance.
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(9844157), Anthony Weber. "Morphine administration by paramedics: An application of the theory of planned behaviour." Thesis, 2014. https://figshare.com/articles/thesis/Morphine_administration_by_paramedics_An_application_of_the_theory_of_planned_behaviour/13387235.

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The core principles of the Queensland Ambulance Service (QAS) that are founded on improving the health and well-being of all persons have remained relatively stable since 1892. This is despite changes in organisational structure, policies, protocols and procedures employed by operational paramedics. The primary scope of QAS operations is focused on the pre-hospital aspects of the health care continuum and has seen changes over time, with particularly rapid changes in the last two years to the content and nature of paramedic clinical practice. Timely and appropriate pain management in the pre-hospital environment is paramount to effective patient care. It is readily identified as a priority within the paramedic profession. Numerous studies have identified many factors that hinder the delivery of adequate pain management to patients with pain. A comprehensive review of the literature related to prehospital pain management, education and barriers to pain management has been conducted. This thesis has attempted to identify if educational programs improved knowledge and changed clinical behaviour, specifically patient care interventions and patient health outcomes. This information is valuable to those who develop clinical standards and education for ambulance services. As a result, this information could be used to help design programs that better meet the educational needs of paramedics and ultimately the needs of their patients and the community. The literature did not sufficiently identify the influences on clinical behaviour other than knowledge, so from this outcome it was identified that future studies must examine a theoretical model that can be used to assess paramedics’ intention to administer morphine to patients experiencing pain. The Theory of Planned Behaviour (TPB) was identified as an effective model for analyzing paramedic behavioural intention; it was recognised that this theory might help to identify and better understand the constructs of attitudes, social norms and behavioural control beliefs that influence paramedics’ intention to administer opioids to patients with pain. The purpose of this study was to analyse the ability of the direct measures of the Theory of Planned Behaviour (TPB) Model to mediate factors influencing ambulance paramedics’ intention to administer Morphine to patients with pain. Participants of this study were Advanced Care and Intensive Care Paramedics who were deemed competent in Morphine administration through the education division of the Queensland Ambulance Service. Data were collected by means of a questionnaire that used the constructs of the TPB, including subjective norm, perceived behavioural control and attitude. While participants reported strong intentions to administer Morphine they also reported negative attitudes towards the behaviour (morphine administration). The constructs of the TPB explained 26 per cent of the variance in intention to administer Morphine with subjective norm being the strongest significant predictor. The findings related to specific attitudes and normative pressures provide an understanding into paramedic’s pain management behaviour. This research may be the first step to identify if concepts taught in the classroom are being transferred to the clinical setting. Potential findings that may be identified in this study could be used to improve organisational awareness of factors that contribute to the future education and professional development of QAS Paramedics.
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(11161368), Meredith G. Mackowicz. "The impact of treatment modality and psychosocial factors on informal caregivers of people with Parkinson disease." Thesis, 2021.

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Parkinson disease(PD) is a degenerative neurological disorder that impacts a great number of individuals in the United States and often results in significant changes to speech and voice, as well as increased reliance on informal caregivers. Relevant literature has shown that caring for a person with PD can have a negative impact on caregivers but has not explored the relationship between perceived impact of life events or relationship satisfaction and caregiver quality of life(CGQOL), or the impact that therapy delivery paradigm can have on these psychosocial factors and on caregivers of people with PD. The current study examined the psychosocial factors associated with caring for someone who has PD and the effect of therapy delivery paradigm on these factors through regression and mediation analyses. Results indicated that caregiver burden, caregiver depression, and perceived impact of life events (PILES), were significantly associated with CGQOL post-treatment, but quality of life pre-treatment and treatment modality were not significant. Although no evidence of mediation was found in this study, change in PILES scores from pre-to post-treatment was significantly associated with caregivers’ ratings of patient self-efficacy for communication post-treatment, while caregiver burden pre-treatment and self-efficacy for people with disabilities pre-treatment were significantly associated with caregivers’ rating of self-efficacy for people with disabilities post-treatment. Collectively, results from this study suggest that focusing on the psychosocial impact of caregiving is an integral part of the treatment process for any provider working with people with PD. Ensuring that caregivers receive the support and education needed to effectively manage the psychosocial factors associated with caregiving will lead to higher quality of care for the patient, as well as better patient outcomes in therapy, and in their daily lives.
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(9850247), C. Coyle. "Relationships between subjective and objective measures after total knee arthroplasty." Thesis, 2012. https://figshare.com/articles/thesis/Relationships_between_subjective_and_objective_measures_after_total_knee_arthroplasty/13387073.

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Total knee arthroplasty (TKA) has proven successful in treating symptomatic arthritis of the knee. Since its development, many and varied outcome measures have been developed to assess outcome. None have been accepted as the universal standard, although some are widely used. Many measures have no data regarding validity, reliability or responsiveness. There is little guidance or consensus in the literature as to which should be used in clinical practice, research or audit. In addition, there is limited research assessing the relationship between subjective clinical outcome scores, patient perceived reports and objective measures such as the timed up and go test (TUG), knee laxity and muscle strength. Establishing relationships between self report and objective measures may aid clinicians in developing more appropriate interventions. Twenty four patients underwent unilateral TKA and were assessed a mean of 27.5 (SD 11.7) months after surgery. Assessment included four patient reported scores (Knee Outcomes and Osteoarthritis Score, Oxford Knee Score, American Knee Society Score and Short Form 12) and three objective outcome scores (knee laxity, quadriceps muscle strength and timed up and go test (TUG). Significant (<0.05) correlations were demonstrated between the four patient reported scores (r=0.410- 0.786) except the MCS portion of the SF12 (r=0.286-0.483). The TUG was the only objective outcome measure to demonstrate a statistically significant (p=0.0001-0.005) correlation with subjective knee outcome scores (OKS, KOOS and 4 items of the KOOS) (r=--0.557 to -0.770). A patient's ability to walk at a certain pace is correlated with patient satisfaction after TKA. There were no 4 observed correlations between knee laxity or quadriceps muscle strength with the four subjective knee scores. Therefore for a comprehensive assessment of outcome after TKA, use of a combination of objective and subjective outcome measures is recommended, as they measure different aspects of outcome.
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Massy-Westropp, Nicola. "Measurement of activity-related changes in the hand." 2005. http://arrow.unisa.edu.au:8081/1959.8/46718.

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The hypothesis underlying this research is that hand activity produces changes in the tissues of the hand which are reflected in the various functions of those tissues. Understanding the effect of hand activity upon hand function would allow occupational therapists to assess the efficacy of therapeutic interventions upon a clients ability to perform hand activity without damage to the tissues of the hand. Such information could assist in the design of safe and sustainable work tasks. The first step towards understanding how activity affects the hand is to measure its effects. The aim of this research is to determine which instruments can measure the effects of activity upon the hand.
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(9166931), Kerri E. Rodriguez. "The Effects of Service Dogs on Individuals with Physical Disabilities and Mental Disorders: A Multimethod Examination." Thesis, 2020.

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An increasing number of individuals with physical disabilities or mental disorders are incorporating specially trained service dogs as an assistance aid to improve functionality. In addition to the tasks that service dogs are rained for, studies also suggest that service dogs may benefit psychosocial health and wellbeing. However, current knowledge on these potential benefits is limited by methodological weaknesses without multi-method assessment. There remains a need for empirical and replicable quantification the psychosocial outcomes of service dog assistance and companionship.

The objective of Chapters 1-3 was to summarize, evaluate, and quantify the effects of service dogs on psychosocial health among individuals with physical disabilities. Chapter 1 conducted a systematic literature review of N=24 articles describing the effects of guide, hearing, mobility, and medical service dogs on standardized measures of psychosocial functioning. Chapters 2 and 3 conducted an empirical investigation using quantitative and qualitative methods to quantify the psychosocial effects of mobility and medical service dogs among N=154 individuals with physical disabilities. Results identified specific psychological, social, and emotional benefits that are associated with having an assistance dog or service dog among diverse populations with physical disabilities or chronic conditions.

The objective of Chapters 4-6 was to quantify the role of psychiatric service dogs for post-9/11 military veterans with PTSD. Chapter 4 quantified the perceived importance, frequency of use, and therapeutic value of service dog behaviors for N=216 military veterans with PTSD. Chapters 5 and 6 then quantified the effects that PTSD service dogs on psychosocial outcomes and physiological indicators of functioning, respectively, among a sample of N=141 military veterans with PTSD. Results identified therapeutic components, tangible psychosocial benefits, and potential physiological mechanisms of psychiatric service dogs for military veterans with PTSD.

Overall, this research combined quantitative, qualitative, and physiological measurement to describe outcomes of service dog pairings in two different at-risk populations. Results provide non-causational evidence of psychosocial benefits from service dogs for individuals with physical disabilities or mental disorders. Findings provide a basis for further large-scale research to disentangle active components of the assistance dog-human partnership and identify potential mediating variables of effects.
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(6989891), Carrie Lynn Shorey. "Multimorbidity and Cognitive Decline in Aging Adults." Thesis, 2019.

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This study explored longitudinal change in executive function (EF) and episodic memory (EM) related to multimorbidity, number of chronic conditions, change in chronic conditions overtime in a nationally representative sample of young, middle-aged,and older adults. Participants were from the second (2004-2006) and third (2013-2015) waves of the Survey of Midlife Development in the United States (MIDUS; N=2,532). Participants completed telephone interviews and questionnaires providing information on demographics and chronic conditions. The Brief Test of Adult Cognition by Telephone (BTACT) assessedcognitive function. The BTACT includes measures of EM (ex. word list recall) and EF (ex. digits backward, category fluency, etc.).Overall, only change in chronic conditions was associated with EF decline in the whole sample. In young adults multimorbidity and number of chronic conditions was significantly associated with both EF and EM decline, whereas only change in number of chronic conditions was significantly associated with EF decline in middle aged adults.Future research is needed to assess a broader range of chronic conditions to determine their overall burden on EF and EM over time.
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Books on the topic "Clinical Sciences not elsewhere classified"

1

Grant, Jon E., and Marc N. Potenza. Overview of the Impulse Control Disorders Not Elsewhere Classified and Limitations of Knowledge. Edited by Jon E. Grant and Marc N. Potenza. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195389715.013.0012.

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Several disorders have been classified together in the American Psychiatric Association’s Diagnostic and Statistical Manual (4th ed.; DSM-IV) as impulse control disorders not elsewhere classified. These impulse control disorders have been grouped together based on perceived similarities in clinical presentation and hypothesized similarities in pathophysiologies. The question exists whether these disorders belong together or whether they should be categorized elsewhere. Examination of the family of impulse control disorders generates questions regarding the distinct nature of each disorder: whether each is unique or whether they represent variations of each other or other psychiatric disorders. Neurobiology may cut across disorders, and identifying important intermediary phenotypes will be important in understanding impulse control disorders and related entities. The distress of patients with impulse control disorders highlights the importance of examining these disorders. More comprehensive information has significant potential for advancing prevention and treatment strategies for those who suffer from disorders characterized by impaired impulse control.
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Mataix-Cols, David, and Odile A. van den Heuvel. Neuroanatomy of Obsessive Compulsive and Related Disorders. Edited by Gail Steketee. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195376210.013.0027.

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Obsessive-compulsive disorder (OCD) shares features and often co-occurs with other anxiety disorders, as well as with other psychiatric conditions classified elsewhere in the Diagnostic and Statistical Manual (DSM-IV), the so-called “OCD spectrum disorders.” Neurobiologically, it is unclear how all these disorders relate to one another. The picture is further complicated by the clinical heterogeneity of OCD. This chapter will review the literature on the common and distinct neural correlates of OCD vis-à-vis other anxiety and “OCD spectrum” disorders. Furthermore, the question of whether partially distinct neural systems subserve the different symptom dimensions of OCD will be examined. Particular attention will be paid to hoarding, which is emerging as a distinct entity from OCD. Finally, new insights from cognitive and affective neuroscience will be reviewed before concluding with a summary and recommendations for future research.
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Milcu, Marius, Saul Neves de Jesus, and Michael Stevens. Rethinking applied psychology. Research paradigms vs. practical approaches. Editura Universitara, 2020. http://dx.doi.org/10.5682/9786062812195.

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Rethinking Applied Psychology: Research Paradigms vs. Practical Approaches is the 2020 edition of proceedings drawn from the annual meeting of the Association for Qualitative and Intercultural Studies. Ordinarily held in Sibiu, Romania, this year’s conference was entirely online. By any measure, it was an outstanding success, due to the ingenuity and industry of conference President, Conf. univ. dr. habil. Marius Milcu. Given the demands and unpredictability of COVID 19, Rethinking Applied Psychology must be seen as a triumph, keeping intact the 14-year tradition of uninterrupted publication of conference proceedings that feature integrative and applied research. This year’s volume is the culmination interdisciplinary and interprofessional collaboration on a wide range of contemporary topics of interest to participants from Romania and elsewhere. These topics covered innovative research methods and practices in clinical psychology and psychotherapy; educational psychology and pedagogical science; work, organizational, and transportation psychology; forensic and military psychology; and social and transcultural psychology. The contributors to this book are highly regarded experts and aspiring young scholars in psychology and allied fields of sociology, education, and health sciences. Rethinking Applied Psychology is proof of the value of research with a social conscience, research that is of benefit to the individual and society.
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Book chapters on the topic "Clinical Sciences not elsewhere classified"

1

"Psychotic disorders not elsewhere classified (including mania and depression with psychotic features)." In Clinical Child Neuropsychiatry, 268–73. Cambridge University Press, 1995. http://dx.doi.org/10.1017/cbo9780511570094.012.

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"Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)." In Pediatric ICD-10-CM 2023. 8th ed. American Academy of PediatricsItasca, IL, 2023. http://dx.doi.org/10.1542/9781610026437-ch18.

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"Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)." In Pediatric ICD-10-CM, 259–69. American Academy of Pediatrics, 2016. http://dx.doi.org/10.1542/9781610020435-ch18.

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"Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)." In Pediatric ICD-10-CM 2018: A Manual for Provider-Based Coding, 275–86. American Academy of Pediatrics, 2017. http://dx.doi.org/10.1542/9781610021074-ch18.

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"Symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified (R00–R99)." In Pediatric ICD-10-CM 2022. 7th ed. American Academy of PediatricsItasca, IL, 2021. http://dx.doi.org/10.1542/9781610025539-ch18.

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"Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)." In Pediatric ICD-10-CM: A Manual for Provider Based Coding, 311–23. 6th ed. American Academy of Pediatrics, 2020. http://dx.doi.org/10.1542/9781610024495-ch18.

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"Symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)." In Pediatric ICD-10-CM, 249–59. American Academy of Pediatrics, 2015. http://dx.doi.org/10.1542/9781581109016-ch18.

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"Symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified (R00 - R99)." In Pediatric ICD-10-CM Coding 2019, 4th Ed, 281–92. American Academy of Pediatrics, 2018. http://dx.doi.org/10.1542/9781610022026-ch18.

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"Symptoms, Signs, and Abnormal Clinical and Laboratory Findings Not Elsewhere Classified (R00-R99)." In Principles of Pediatric ICD-10-CM Coding, 199–204. American Academy of Pediatrics, 2013. http://dx.doi.org/10.1542/9781581107593-ch19.

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"18: Symptoms, Signs, and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00 - R99)." In Pediatric ICD-10-CM Coding 2020, 5th Ed, 285–97. American Academy of Pediatrics, 2019. http://dx.doi.org/10.1542/9781610023245-ch18.

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Conference papers on the topic "Clinical Sciences not elsewhere classified"

1

Jugl, Sebastian, Aimalohi Okpeku, Brianna Costales, Earl Morris, Golnoosh Alipour-Harris, Juan Hincapie-Castillo, Nichole Stetten, et al. "A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the United States, from 2016 to 2019." In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.25.

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Background: Medical cannabis is available to patients by physician order in two-thirds of the United States (U.S.) as of 2020, but remains classified as an illicit substance by federal law. States that permit medical cannabis ordered by a physician typically require a diagnosed medical condition that is considered qualifying by respective state law. Objectives: To identify and map the most recently (2016-2019) published clinical and scientific literature across approved conditions for medical cannabis, and to evaluate the quality of identified recent systematic reviews. Methods: Literature search was conducted from five databases (PubMed, Embase, Web of Science, Cochrane, and ClinicalTrials.gov), with expansion and update from the National Academies of Sciences, Engineering, and Medicine’s (NASEM) comprehensive evidence review through 2016 of the health effects of cannabis on several conditions. Following consultation with experts and stakeholders, 11 conditions were identified for evidence evaluation: amyotrophic lateral sclerosis (ALS), autism, cancer, chronic pain, Crohn’s disease, epilepsy, glaucoma, HIV/AIDS, multiple sclerosis (MS), Parkinson’s disease, and posttraumatic stress disorder (PTSD). The following exclusion criteria were imposed: preclinical focus, non-English language, abstracts only, editorials/commentary, case studies/series, and non-U.S. study setting. Data extracted from studies included: study design type, outcome, intervention, sample size, study setting, and reported effect size. Studies classified as systematic reviews with or without meta-analysis were graded using the AMSTAR-2 tool by two raters to evaluate the quality of evidence, with additional raters to resolve cases of evidence grade disagreement. Results: A total of 438 studies were included after screening. Five completed randomized controlled trials (RCTs) were identified, and an additional 11 trials were ongoing, and 1 terminated. Cancer, chronic pain, and epilepsy were the most researched topic areas, representing more than two-thirds of all reviewed studies. The quality of evidence assessment for each condition suggests that few high-quality systematic reviews are available for most conditions, with the exceptions of MS, epilepsy, and chronic pain. In those areas, findings on chronic pain are mostly in alignment with the previous literature, suggesting that cannabis or cannabinoids are potentially beneficial in treating chronic neuropathic pain. In epilepsy, findings suggest that cannabidiol is potentially effective in reducing seizures in pediatric patients with drug-resistant Dravet and Lennox-Gastaut syndromes. In MS, recent high-quality systematic reviews did not include new RCTs, and are therefore not substantially expanding the evidence base. In sum, the most recent clinical evidence suggests that for most of the conditions assessed, we identified few studies of substantial rigor and quality to contribute to the evidence base. However, there are some conditions for which significant evidence suggests that select dosage forms and routes of administration likely have favorable risk-benefit ratios (i.e., epilepsy and chronic pain), with the higher quality of evidence for epilepsy driven by FDA-approved formulations for cannabis-based seizure treatments. Conclusion: The body of evidence for medical cannabis requires more rigorous evaluation before consideration as a treatment option for many conditions and evidence necessary to inform policy and treatment guidelines is currently insufficient for many conditions.
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