Relevant bibliographies by topics / Clinical Practice Research Datalink (CPRD)

Academic literature on the topic 'Clinical Practice Research Datalink (CPRD)'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Clinical Practice Research Datalink (CPRD)"

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Herrett, Emily, Arlene M. Gallagher, Krishnan Bhaskaran, Harriet Forbes, Rohini Mathur, Tjeerd van Staa, and Liam Smeeth. "Data Resource Profile: Clinical Practice Research Datalink (CPRD)." International Journal of Epidemiology 44, no. 3 (June 2015): 827–36. http://dx.doi.org/10.1093/ije/dyv098.

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Schmidt, James C. F., Paul C. Lambert, Clare L. Gillies, and Michael J. Sweeting. "Patterns of rates of mortality in the Clinical Practice Research Datalink." PLOS ONE 17, no. 8 (August 4, 2022): e0265709. http://dx.doi.org/10.1371/journal.pone.0265709.

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The Clinical Practice Research Datalink (CPRD) is a widely used data resource, representative in demographic profile, with accurate death recordings but it is unclear if mortality rates within CPRD GOLD are similar to rates in the general population. Rates may additionally be affected by selection bias caused by the requirement that a cohort have a minimum lookback window, i.e. observation time prior to start of at-risk follow-up. Standardised Mortality Ratios (SMRs) were calculated incorporating published population reference rates from the Office for National Statistics (ONS), using Poisson regression with rates in CPRD GOLD contrasted to ONS rates, stratified by age, calendar year and sex. An overall SMR was estimated along with SMRs presented for cohorts with different lookback windows (1, 2, 5, 10 years). SMRs were stratified by calendar year, length of follow-up and age group. Mortality rates in a random sample of 1 million CPRD GOLD patients were slightly lower than the national population [SMR = 0.980 95% confidence interval (CI) (0.973, 0.987)]. Cohorts with observational lookback had SMRs below one [1 year of lookback; SMR = 0.905 (0.898, 0.912), 2 years; SMR = 0.881 (0.874, 0.888), 5 years; SMR = 0.849 (0.841, 0.857), 10 years; SMR = 0.837 (0.827, 0.847)]. Mortality rates in the first two years after patient entry into CPRD were higher than the general population, while SMRs dropped below one thereafter. Mortality rates in CPRD, using simple entry requirements, are similar to rates seen in the English population. The requirement of at least a single year of lookback results in lower mortality rates compared to national estimates.
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Wolf, Achim, Daniel Dedman, Jennifer Campbell, Helen Booth, Darren Lunn, Jennifer Chapman, and Puja Myles. "Data resource profile: Clinical Practice Research Datalink (CPRD) Aurum." International Journal of Epidemiology 48, no. 6 (March 11, 2019): 1740–1740. http://dx.doi.org/10.1093/ije/dyz034.

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KOECHLIN, ALICE, PETER BOYLE, and PHILIPPE AUTIER. "Heterogeneity between Pharmacoepidemiological Studies Using the Clinical Practice Research Datalink (CPRD)." Diabetes 67, Supplement 1 (May 2018): 1507—P. http://dx.doi.org/10.2337/db18-1507-p.

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Nissen, Francis, Daniel R. Morales, Hana Mullerova, Liam Smeeth, Ian J. Douglas, and Jennifer K. Quint. "Validation of asthma recording in the Clinical Practice Research Datalink (CPRD)." BMJ Open 7, no. 8 (August 2017): e017474. http://dx.doi.org/10.1136/bmjopen-2017-017474.

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ObjectivesThe optimal method of identifying people with asthma from electronic health records in primary care is not known. The aim of this study is to determine the positive predictive value (PPV) of different algorithms using clinical codes and prescription data to identify people with asthma in the United Kingdom Clinical Practice Research Datalink (CPRD).Methods684 participants registered with a general practitioner (GP) practice contributing to CPRD between 1 December 2013 and 30 November 2015 were selected according to one of eight predefined potential asthma identification algorithms. A questionnaire was sent to the GPs to confirm asthma status and provide additional information to support an asthma diagnosis. Two study physicians independently reviewed and adjudicated the questionnaires and additional information to form a gold standard for asthma diagnosis. The PPV was calculated for each algorithm.Results684 questionnaires were sent, of which 494 (72%) were returned and 475 (69%) were complete and analysed. All five algorithms including a specific Read code indicating asthma or non-specific Read code accompanied by additional conditions performed well. The PPV for asthma diagnosis using only a specific asthma code was 86.4% (95% CI 77.4% to 95.4%). Extra information on asthma medication prescription (PPV 83.3%), evidence of reversibility testing (PPV 86.0%) or a combination of all three selection criteria (PPV 86.4%) did not result in a higher PPV. The algorithm using non-specific asthma codes, information on reversibility testing and respiratory medication use scored highest (PPV 90.7%, 95% CI (82.8% to 98.7%), but had a much lower identifiable population. Algorithms based on asthma symptom codes had low PPVs (43.1% to 57.8%)%).ConclusionsPeople with asthma can be accurately identified from UK primary care records using specific Read codes. The inclusion of spirometry or asthma medications in the algorithm did not clearly improve accuracy.Ethics and disseminationThe protocol for this research was approved by the Independent Scientific Advisory Committee (ISAC) for MHRA Database Research (protocol number15_257) and the approved protocol was made available to the journal and reviewers during peer review. Generic ethical approval for observational research using the CPRD with approval from ISAC has been granted by a Health Research Authority Research Ethics Committee (East Midlands—Derby, REC reference number 05/MRE04/87).The results will be submitted for publication and will be disseminated through research conferences and peer-reviewed journals.
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Sammon, Cormac J., Thomas P. Leahy, and Sreeram Ramagopalan. "Nonindependence of patient data in the clinical practice research datalink: a case study in atrial fibrillation patients." Journal of Comparative Effectiveness Research 9, no. 6 (April 2020): 395–403. http://dx.doi.org/10.2217/cer-2019-0191.

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Aim: The impact of different strategies to handle patients with data recorded under multiple Clinical Practice Research Datalink (CPRD) identifiers (IDs) is unknown. Patients and methods: Six approaches to handling patients appearing under multiple CPRD IDs were defined. The impact of the approaches was illustrated using a case study describing the clinical characteristics of a population of nonvalvular atrial fibrillation patients. Results: 5.6% of patients had more than one CPRD ID. Across all six approaches implemented, no material difference in the characteristics of nonvalvular atrial fibrillation patients were observed. Conclusion: While strategies which longitudinally append patient registration periods under different CPRD IDs maintain independence while using all available data, their implementation had little impact on the results of our case study.
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Rebordosa, Cristina, Estel Plana, Jaume Aguado, Steven Thomas, Esther García-Gil, Susana Perez‐Gutthann, and Jordi Castellsague. "GOLD assessment of COPD severity in the Clinical Practice Research Datalink (CPRD)." Pharmacoepidemiology and Drug Safety 28, no. 2 (May 8, 2018): 126–33. http://dx.doi.org/10.1002/pds.4448.

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Leite, Andreia, Sara L. Thomas, and Nick J. Andrews. "Implementing near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD)." Vaccine 35, no. 49 (December 2017): 6885–92. http://dx.doi.org/10.1016/j.vaccine.2017.09.022.

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Gulliford, Martin C., Xiaohui Sun, Thamina Anjuman, Eleanor Yelland, and Tarita Murray-Thomas. "Comparison of antibiotic prescribing records in two UK primary care electronic health record systems: cohort study using CPRD GOLD and CPRD Aurum databases." BMJ Open 10, no. 6 (June 2020): e038767. http://dx.doi.org/10.1136/bmjopen-2020-038767.

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ObjectivesWe aimed to evaluate recording of antibiotic prescribing from two primary care electronic health record systems.DesignCohort study.SettingUK general practices contributing to the Clinical Practice Research Datalink (CPRD) databases: CPRD GOLD (Vision data) and CPRD Aurum (EMIS data). English CPRD GOLD general practices were analysed as a subgroup, as all CPRD Aurum practices were located in England.Participants158 305 patients were randomly sampled from CPRD Aurum and 160 394 from CPRD GOLD.Outcome measuresAntibiotic prescriptions in 2017 were identified. Age-standardised and sex-standardised antibiotic prescribing rates per 1000 person years were calculated. Prescribing of individual antibiotic products and associated medical diagnoses was evaluated.ResultsThere were 101 360 antibiotic prescriptions at 883 CPRD Aurum practices and 112 931 prescriptions at 290 CPRD GOLD practices, including 112 general practices in England. The age-standardised and sex-standardised antibiotic prescribing rate in 2017 was 512.6 (95% CI 510.4 to 514.9) per 1000 person years in CPRD Aurum and 584.3 (582.1 to 586.5) per 1000 person years in CPRD GOLD (505.2 (501.6 to 508.9) per 1000 person years if restricted to practices in England). The 25 most frequently prescribed antibiotic products were similar in both databases. One or more medical codes were recorded on the same date as an antibiotic prescription for 72 989 (74%) prescriptions in CPRD Aurum, 84 756 (78%) in CPRD GOLD and 28 471 (78%) for CPRD GOLD in England. Skin, respiratory and genitourinary tract infections were recorded for 39 035 (40%) prescriptions in CPRD Aurum, 41 326 (38%) in CPRD GOLD, with 15 481 (42%) in English CPRD GOLD practices only.ConclusionEstimates for antibiotic prescribing and infection recording were broadly similar in both databases suggesting similar recording across EMIS and Vision systems. Future research on antimicrobial stewardship can also be conducted using primary care data in CPRD Aurum.
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Booth, Helen, Eleanor Yelland, David Mullett, Arlene Gallagher, Shivani Padmanabhan, Stephen Welburn, Janet Valentine, and Puja Myles. "The Royal College of General Practitioners (RCGP) quality improvement initiative using Clinical Practice Research Datalink (CPRD) data: Lessons learned." British Journal of General Practice 69, suppl 1 (June 2019): bjgp19X703697. http://dx.doi.org/10.3399/bjgp19x703697.

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BackgroundQuality improvement (QI) is a priority for general practice, and GPs are expected to participate and provide evidence of QI activity. Pressures on the primary care workforce require approaches to QI to prioritise efficiency and effectiveness.AimThis project aimed generate and scale up bespoke QI reports for GP practices contributing data to CPRD.MethodCPRD is a UK government research service facilitating public health research using anonymised primary care data. A pilot report was designed with stakeholders and covered two indicators from the RCGP Patient Safety Toolkit. The reports enabled GPs to identify patients needing case review and to benchmark data on practice-level prescribing. Reports for 12 practices, containing real patient data, were sent to GPs and feedback was obtained via interviews. The report was scaled up to 457 practices and a survey sent out to request feedback.ResultsGPs used the reports to review the care of individual patients, and to implement QI actions such as adding flags to patients notes. One participant used the report as evidence for their annual appraisal. Survey response was limited (n = 31.7%) but overwhelmingly positive. Responders highlighted the importance of clinical input when developing indicators and ensuring the tone of the reports is supportive.ConclusionThe collaborative RCGP/CPRD QI reports are unique in their ability to provide benchmarking and case-finding on a national scale. The indicators selected must lead to actionable reports. Clinical input is required to ensure code lists are appropriate and that reports are clinically relevant. CPRD aims to send out two reports annually.
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Dissertations / Theses on the topic "Clinical Practice Research Datalink (CPRD)"

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Thomas, Kyla Hayley. "The association of prescribed drugs with psychiatric adverse drug reactions : analysis of data from the clinical practice research datalink (CPRD) and Yellow Card Scheme." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633443.

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Smoking cessation medicines, such as varenicline and bupropion, have been shown to be clinically effective and cost effective. However, there have been ongoing concerns that these medicines may cause psychiatric adverse drug reactions (ADRs) such as suicide. Safety warnings in relation to these drugs have been issued by regulatory agencies in the UK and USA. The aim of this thesis was to use data from two key pharmacoepidemiology and pharmacovigilance tools in the UK, the Yellow Card Scheme and the Clinical Practice Research Datalink (CPRD), to identify the risk of depression, non-fatal self-harm and suicide, associated with varenicline. First, I described the drug classes which have been associated with frequent Yellow Card reports of depression, non-fatal self-harm and suicide. I found that many different drugs are associated with reports of depression and suicide related events. These include drugs used for non psychiatric indications such as the smoking cessation medicines varenicline and bupropion, isotretinoin (used in acne treatment) and the antiretroviral drug efavirenz, in addition to drugs used for psychiatric indications such as the selective serotonin reuptake inhibitors (SSRls), antipsychotic medications and hypnotics. There was strong positive correlation between reporting rates of depression and suicide related events for psychiatric and non psychiatric drugs, providing indirect evidence of possible causal associations.
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Prasad, Vibhore. "The epidemiology of injuries in epilepsy and attention deficit-hyperactivity disorder (ADHD) in children and young people using the Clinical Practice Research Datalink (CPRD) and linked data." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33216/.

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Background: Injuries are a leading cause of morbidity and mortality in children and young people (CYP) throughout the world and in the UK. Detailed estimates of the risk of specific injuries, namely fractures, thermal injuries and poisonings, are not available for CYP with specific medical conditions, such as epilepsy or attention deficit-hyperactivity disorder (ADHD) in the English primary care population. To date there has been no description of the recording of ADHD by general practitioners (GPs) in English primary care according to people’s area-level social deprivation and strategic health authority (SHA) region. Objectives: 1. To define a cohort of CYP with epilepsy from the UK primary care population. 2. To estimate the risk of specific injuries, namely fractures, thermal injuries and poisonings in CYP with epilepsy compared to CYP without epilepsy. 3. To define and describe the cumulative administrative prevalence of ADHD in CYP in English primary care overall and by age, sex, SHA region, deprivation and calendar time. 4. To estimate the risk of specific injuries, namely fractures, thermal injuries and poisonings in CYP with ADHD compared to CYP without ADHD. Methods: This thesis describes work conducted using a large primary care dataset (the Clinical Practice Research Datalink (CPRD)) containing GP medical records and, for a proportion, linked hospital records from the hospital episodes statistics (HES) database. Firstly, the CPRD was used to define a cohort of CYP with epilepsy and CYP without epilepsy. The GP medical records for this cohort were used to estimate the risk of fractures, thermal injuries and poisonings, in CYP with epilepsy compared to CYP without epilepsy. The rates of injuries were estimated by age and sex. For a proportion of people in this study, the effect on estimates of using linked hospital medical records in addition to the GP medical records was evaluated. Secondly, the administrative prevalence of ADHD recorded by GPs was defined for CYP in England by identifying a cohort of CYP in the CPRD with GP medical records linked to hospital medical records. The cumulative administrative prevalence of ADHD was estimated overall and by age, sex, SHA region, deprivation and calendar time. Thirdly, the GP medical records and linked hospital medical records for the cohort of CYP with ADHD was used to estimate the risk of fractures, thermal injuries and poisonings, in CYP with ADHD compared to CYP without ADHD. The rates of injuries were estimated by age, sex and deprivation. Findings: CYP with epilepsy are at greater risk of fractures, thermal injuries and poisonings compared to CYP without epilepsy. In CYP with epilepsy the incidence of fractures is 18% higher, thermal injuries is 50% higher and poisonings 147% higher than in CYP without epilepsy, with the increased risk being restricted to medicinal poisonings. Among young adults with epilepsy, aged 19 to 24 years, the incidence rate of medicinal poisoning is four-fold that of the general population of the same age. Using GP medical records and linked hospital medical records may improve the ascertainment of injuries. For example, if hospital medical records are used in addition to GP medical records to ascertain femur fractures, a further 33% of fractures may be ascertained compared to using GP medical records alone. In comparison, if hospital medical records were used without GP medical records, 10% of femur fractures may not be ascertained. However, this increased ascertainment of injuries is unlikely to alter the estimates of risk of injuries in people with epilepsy when compared to people without epilepsy (e.g. risk of long bone fractures: using hospital and GP medical records, hazard ratio (HR)=1.25 (95% confidence interval (95%CI) 1.07 to 1.46) vs. using GP medical records alone, HR=1.23 (95%CI 1.10 to 1.38)). The administrative prevalence of ADHD in CYP aged 3 to 17 years old in English GP medical records is 0.88% (95% confidence interval (95%CI) 0.87 to 0.89). The prevalence of ADHD recorded by GPs is around five times greater in males than in females. The administrative prevalence of ADHD appears to increase with age, with the lowest prevalence in 3 to 4 year-olds (0.02 (95%CI 0.02 to 0.03)) and the highest prevalence in 15 to 17 year olds (1.38 (95%CI 1.36 to 1.40)). The administrative prevalence of ADHD is twice as high in CYP from the most deprived areas compared to CYP from the least deprived areas (1.14% (95%CI 1.12 to 1.16) in the most deprived areas to 0.64% (95%CI 0.63 to 0.65) in the least deprived areas)). CYP with ADHD are at greater risk of fractures, thermal injuries and poisonings compared CYP without ADHD. In CYP with ADHD the incidence of fractures is 28% higher, thermal injuries is 104% higher and poisonings is 300% higher than in CYP without ADHD. Conclusions: CYP with epilepsy and ADHD have an increased risk of fracture, thermal injury and poisoning compared to CYP without these conditions. For both conditions the risk of poisoning is higher than the risk of fractures or thermal injuries. The administrative prevalence of ADHD is lower than estimates of community prevalence ascertained from studies not using primary care data. The prevalence of ADHD varied with deprivation, being almost twice as high in CYP from the most deprived areas compared to CYP from the least deprived areas. Future research is required to explore the circumstances surrounding injuries in CYP with and without epilepsy and ADHD. Future research is also required to explore the effect of treating epilepsy and ADHD with medication on injury risk. Research is required to explore the effect of the severity of epilepsy and ADHD on estimated risks of injuries. Future research exploring potential under-diagnosis or under-recording of diagnosis of ADHD in CYP in primary care is needed. CYP with epilepsy and ADHD and their parents should be provided with evidence-based injury prevention interventions because work in this thesis has demonstrated they are at higher risk of injury than the general population of CYP. Health care professionals working with CYP; child and adolescent mental health services; child education or care practitioners; and other agencies and organisations with an injury prevention role, should be made aware of the increased risk of injury in CYP with epilepsy and ADHD. Commissioners of health services for CYP should ensure service specifications include injury prevention training and provision for evidence-based injury prevention interventions.
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Clarson, Lorna Elise. "Risk of incident vascular disease in patients with gout : an observational study in the Clinical Practice Research Datalink." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2309/.

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Gout is the most prevalent inflammatory arthritis, predominantly managed in primary care. Both hyperuricaemia (the biochemical precursor to gout) and other inflammatory arthritides, e.g. rheumatoid arthritis, have been shown to increase risk of vascular disease. This thesis aims to investigate the risk of incident cardiovascular, cerebrovascular and peripheral vascular disease in primary care gout patients. A systematic review identified 17 studies investigating gout and vascular diseases. Meta-analysis showed increased mortality from all cardiovascular and coronary heart disease. Increased incidence of, but not mortality from myocardial infarction was found. Few studies investigated the association between gout and cerebrovascular or peripheral vascular disease. A retrospective cohort study used data from the Clinical Practice Research Datalink to examine the risk of incident cardiovascular, cerebrovascular and peripheral vascular disease in 8386 gout patients and 39766 age-, gender- and practice-matched controls, in the ten years following diagnosis of gout (or matched date) using Cox proportional hazards and multilevel discrete-time event history analysis. Risk was also investigated by gender and with follow-up limited to one, two and five years. The effect of exposure to drugs used to treat both gout and vascular risk factors on the magnitude of risk was examined using a cohort and nested case-control study design. The strongest association identified was between gout and peripheral vascular disease. Women with gout had the greatest excess vascular risk and experienced a wider range of vascular events. Exposure to drugs used to manage vascular risk factors was associated with increased likelihood of a vascular event, but use of gout treatments such as allopurinol did not influence incident vascular risk. This suggests that gout patients, particularly women, should have screening for and aggressive management of vascular risk factors, although as conventional approaches may be insufficient, further research is required to establish the optimum risk reduction strategy.
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Price, Sarah Jane. "What are we missing by ignoring text records in the Clinical Practice Research Datalink? : using three symptoms of cancer as examples to estimate the extent of data in text format that is hidden to research." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/21692.

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Electronic medical record databases (e.g. the Clinical Practice Research Datalink, CPRD) are increasingly used in epidemiological research. The CPRD has two formats of data: coded, which is the sole format used in almost all research; and free-text (or ‘hidden’), which may contain much clinical information but is generally unavailable to researchers. This thesis examines the ramifications of omitting free-text records from research. Cases with bladder (n=4,915) or pancreatic (n=3,635) cancer were matched to controls (n=21,718, bladder; n=16,459, pancreas) on age, sex and GP practice. Coded and text-only records of attendance for haematuria, jaundice and abdominal pain in the year before cancer diagnosis were identified. The number of patients whose entire attendance record for a symptom/sign existed solely in the text was quantified. Associations between recording method (coded or text-only) and case/control status were estimated (χ2 test). For each symptom/sign, the positive predictive value (PPV, Bayes' Theorem) and odds ratio (OR, conditional logistic regression) for cancer were estimated before and after supplementation with text-only records. Text-only recording was considerable, with 7,951/20,958 (37%) of symptom records being in that format. For individual patients, text-only recording was more likely in controls (140/336=42%) than cases (556/3,147=18%) for visible haematuria in bladder cancer (χ2 test, p<0.001), and for jaundice (21/31=67% vs 463/1,565=30%, p<0.0001) and abdominal pain (323/1,126=29% vs 397/1,789=22%, p<0.001) in pancreatic cancer. Adding text records reduced PPVs of visible haematuria for bladder cancer from 4.0% (95% CI: 3.5–4.6%) to 2.9% (2.6–3.2%) and of jaundice for pancreatic cancer from 12.8% (7.3–21.6%) to 6.3% (4.5–8.7%). Coded records suggested that non-visible haematuria occurred in 127/4,915 (2.6%) cases, a figure below that generally used for study. Supplementation with text-only records increased this to 312/4,915 (6.4%), permitting the first estimation of its OR (28.0, 95% CI: 20.7–37.9, p<0.0001) and PPV (1.60%, 1.22–2.10%, p<0.0001) for bladder cancer. The results suggest that GPs make strong clinical judgements about the probable significance of symptoms – preferentially coding clinical features they consider significant to a diagnosis, while using text to record those that they think are not.
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Book chapters on the topic "Clinical Practice Research Datalink (CPRD)"

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Gallagher, Arlene M., Antonis A. Kousoulis, Tim Williams, Janet Valentine, and Puja Myles. "Clinical Practice Research Datalink (CPRD)." In Databases for Pharmacoepidemiological Research, 57–65. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51455-6_3.

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Parkinson, John. "The Clinical Practice Research Datalink: The New 54 Million Fully Integrated Research Data and Clinical Trial System." In Mann's Pharmacovigilance, 421–28. Oxford, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118820186.ch26.

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Conference papers on the topic "Clinical Practice Research Datalink (CPRD)"

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Mathioudakis, Alexander, Jorgen Vestbo, Alicia Gayle, Scott Dickinson, Kevin Morris, Samantha Webster, and Chris Poole. "GOLD ABCD assessment tool: Comparison of 2013 and 2017 classifications in the UK Clinical Practice Research Datalink (CPRD)." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa2011.

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Oshagbemi, Olorunfemi, Frits Franssen, Emiel Wouters, Anke-Hilse Maitland-Van Der Zee, Johanna Driessen, Anthonius De Boer, Frank Devries, and Dionne Braeken. "Blood eosinophil counts, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality in the Clinical Practice Research Datalink (CPRD)." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa3373.

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Gayle, Alicia, Eleanor Axson, Chloe Bloom, Vidya Navaratnam, and Jennifer Quint. "Mortality rates of COPD Patients in UK Electronic Health Records (Clinical Practice Research Datalink)." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa4484.

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Landis, Sarah, Robert Suruki, and Nicolas Galwey. "LATE-BREAKING ABSTRACT: Stability of blood eosinophil count in COPD patients in the UK clinical practice research datalink." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa4047.

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Rothnie, Kieran, Hana Mullerova, John Hurst, Liam Smeeth, Kourtney Davis, Sara Thomas, and Jennifer Quint. "Validation of the recording of acute exacerbations of COPD in the clinical practice research datalink: Phase 1 results." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa4067.

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McGlynn, Katherine A., Katrina Hagberg, Jie Chen, Susan Jick, and Vikrant V. Sahasrabuddhe. "Abstract 879: Menopausal hormone therapy and risk of primary liver cancer in the UK Clinical Practice Research Datalink." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-879.

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Gayle, A., M. Pang, A. Tebboth, F. Guelfucci, R. Argoubi, S. Sherman, and V. Mak. "S101 Prescribing patterns in adults with asthma in the UK: a descriptive study using the clinical practice research datalink." In British Thoracic Society Winter Meeting 2018, QEII Centre, Broad Sanctuary, Westminster, London SW1P 3EE, 5 to 7 December 2018, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2018. http://dx.doi.org/10.1136/thorax-2018-212555.107.

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Head, A., K. Fleming, C. Kypridemos, P. Schofield, and M. O’Flaherty. "OP29 Dynamics of multimorbidity in England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink." In Society for Social Medicine and Population Health Annual Scientific Meeting 2020, Hosted online by the Society for Social Medicine & Population Health and University of Cambridge Public Health, 9–11 September 2020. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/jech-2020-ssmabstracts.29.

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Tsilidis, Konstantinos K., Despoina Capothanassi, Naomi Allen, Evangelos Rizos, David Lopez, Karin van Veldhoven, Carlotta Sacerdote, et al. "Abstract 2161: Metformin and cancer risk: A cohort study in the UK Clinical Practice Research Datalink analyzed like a randomized trial." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2161.

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Head, Anna, Kate Fleming, Chris Kypridemos, Pietà Schofield, and Martin O’Flaherty. "P61 Regional inequalities in multimorbidity within England between 2004 and 2019: a descriptive epidemiology study using the clinical practice research datalink." In Society for Social Medicine Annual Scientific Meeting Abstracts. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/jech-2021-ssmabstracts.149.

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