Relevant bibliographies by topics / Clinical determinant

Academic literature on the topic 'Clinical determinant'

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Published: 25 May 2024

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Journal articles on the topic "Clinical determinant"

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Yu, M., J. M. Johnson, and V. K. Tuohy. "A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease." Journal of Experimental Medicine 183, no. 4 (April 1, 1996): 1777–88. http://dx.doi.org/10.1084/jem.183.4.1777.

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The development of autoimmune disease is accompanied by the acquired recognition of new self-determinants, a process commonly referred to as determinant spreading. In this study, we addressed the question of whether determinant spreading is pathogenic for progression of chronic-relapsing experimental autoimmune encephalomyelitis (EAE), a disease with many similarities to multiple sclerosis (MS). Our approach involved a systematic epitope mapping of responses to myelin proteolipid protein (PLP) as well as assaying responses to known encephalitogenic determinants of myelin basic protein (MBP 87-89) and myelin oligodendrocyte glycoprotein (MOG 92-106) at various times after induction of EAE in (SWR X SJL)F1 mice immunized with PLP 139-151. We found that the order in which new determinants are recognized during the course of disease follows a predictable sequential pattern. At monthly intervals after immunization with p139-151, responses to PLP 249-273, MBP 87-99, and PLP 137-198 were sequentially accumulated in al mice examined. Three lines of evidence showed that determinant spreading is pathogenic for disease progression: (a) spreading determinants mediate passive transfer of acute EAE in naive (SWR X SJL)F1 recipients; (b) an invariant relationship exists between the development of relapse/progression and the spreading of recognition to new immunodominant encephalitogenic determinants; and (c) after EAE onset, the induction of peptide-specific tolerance to spreading but not to nonspreading encephalitogenic determinants prevents subsequent progression of EAE. Thus, the predictability of acquired self-determinant recognition provides a basis for sequential determinant-specific therapeutic intervention after onset of the autoimmune disease process.
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Roberts, M. C., W. O. Chung, and D. E. Roe. "Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola." Antimicrobial Agents and Chemotherapy 40, no. 7 (July 1996): 1690–94. http://dx.doi.org/10.1128/aac.40.7.1690.

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Treponema denticola isolates were evaluated for the presence of known tetracycline and erythromycin resistance determinants by Southern blot hybridization of whole-cell DNA and PCR assays. We examined all isolates available, which included 12 clinical and 4 American Type Culture Collection isolates. Two isolates carried the Tet B determinant, five isolates carried both the Tet B and Erm F determinants, seven isolates carried the Erm F determinant, and two did not carry any of the Tet or Erm determinants tested. Both the Tet B and Erm F determinants appeared to be associated with the chromosome. Neither of the two T. denticola donors tested could transfer the Tet B determinant, but three of four T. denticola tested transferred the Erm F determinant to an Enterococcus faecalis recipient. This extends the host range of both the tetB and ermF genes into the genus Treponema.
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Bachelot, Anne, Jean Louis Golmard, Jérôme Dulon, Nora Dahmoune, Monique Leban, Claire Bouvattier, Sylvie Cabrol, Juliane Leger, Michel Polak, and Philippe Touraine. "Determining clinical and biological indicators for health outcomes in adult patients with childhood onset of congenital adrenal hyperplasia." European Journal of Endocrinology 173, no. 2 (August 2015): 175–84. http://dx.doi.org/10.1530/eje-14-0978.

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AimAdverse outcomes in adult congenital adrenal hyperplasia (CAH) patients are frequent. The determinants of them have not yet been established.ObjectiveTo establish the prevalence of adverse outcomes and to find determining factors for each of them.Design, patients, and methodsCross-sectional monocentric study of 104 patients with childhood onset of CAH (71 women, 33 men). Analysis established first the determinants of clinical, hormonal, genetic variables and second a composite criterion for some of the outcomes and determinants.ResultsBMI was above 25 kg/m2 in 44% of the cohort, adrenal hyperplasia and/or nodules were present in 45% of the patients, and irregular menstrual cycles and hyperandrogenism were found in 50 and 35% of the women respectively. In univariate analysis, the determinants of these outcomes were all linked to disease control, especially 17-hydroxyprogesterone (17OHP) and androstenedione concentrations. Low weight was a determinant of abnormal bone mineral density (BMD) (60% of the cohort). Multivariate analysis confirmed these data. A classic form (CF) of CAH was a determinant of testicular adrenal rest tumors (TARTs) (36% of the men). Total cumulative glucocorticoid dose was a determinant of BMI and TART, whereas fludrocortisone dose was a determinant of TART (P=0.03). In men, the composite criterion was associated with androstenedione concentration and CF. In women, the composite criterion was associated with total testosterone concentration.ConclusionThe present study confirms the high prevalence of adverse outcomes in CAH patients. These are, most often, related to disease control. The impaired health status of adults with CAH could therefore be improved through the modification of treatment.
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Erac, Bayri, Fethiye Ferda Yilmaz, Ismail Ozturk, Sabire Sohret Aydemir, and Mine Hosgor-Limoncu. "Analyses of Plasmids Harbouring Quinolone Resistance Determinants in Enterobacteriaceae Members." Polish Journal of Microbiology 66, no. 4 (December 4, 2017): 529–32. http://dx.doi.org/10.5604/01.3001.0010.7084.

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The aim of this study was to explore the plasmid characteristics of eight clinical Enterobacteriaceae strains containing extended broad spectrum beta-lactamases and plasmid-mediated quinolone resistance. Plasmids were transferred by conjugation or transformation and resistance determinants were investigated by PCR. We showed that at least one plasmid harbouring qnrB or qnrS determinant was transferred by conjugation in five isolates. QepA determinant was confirmed to be on a non-conjugative plasmid. We found at least one beta-lactamase gene in seven of the eight clinical isolates having plasmid-mediated quinolone resistance, which indicated that these two resistance determinants were mostly on the same conjugative plasmids.
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Tuckman, Margareta, Peter J. Petersen, Anita Y. M. Howe, Mark Orlowski, Stanley Mullen, Karen Chan, Patricia A. Bradford, and C. Hal Jones. "Occurrence of Tetracycline Resistance Genes among Escherichia coli Isolates from the Phase 3 Clinical Trials for Tigecycline." Antimicrobial Agents and Chemotherapy 51, no. 9 (July 9, 2007): 3205–11. http://dx.doi.org/10.1128/aac.00625-07.

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ABSTRACT Tigecycline, a member of the glycylcycline class of antibiotics, was designed to maintain the antibacterial spectrum of the tetracyclines while overcoming the classic mechanisms of tetracycline resistance. The current study was designed to monitor the prevalence of the tet(A), tet(B), tet(C), tet(D), tet(E), and tet(M) resistance determinants in Escherichia coli isolates collected during the worldwide tigecycline phase 3 clinical trials. A subset of strains were also screened for the tet(G), tet(K), tet(L), and tet(Y) genes. Of the 1,680 E. coli clinical isolates screened for resistance to classical tetracyclines, 405 (24%) were minocycline resistant (MIC ≥ 8 μg/ml) and 248 (15%) were tetracycline resistant (MIC ≥ 8 μg/ml) but susceptible to minocycline (MIC ≤ 4 μg/ml). A total of 452 tetracycline-resistant, nonduplicate isolates were positive by PCR for at least one of the six tetracycline resistance determinants examined. Over half of the isolates encoding a single determinant were positive for tet(A) (26%) or tet(B) (32%) with tet(C), tet(D), tet(E), and tet(M), collectively, found in 4% of isolates. Approximately 33% of the isolates were positive for more than one resistance determinant, with the tet(B) plus tet(E) combination the most highly represented, found in 11% of isolates. The susceptibilities of the tetracycline-resistant strains to tigecycline (MIC90, 0.5 μg/ml), regardless of the encoded tet determinant(s), were comparable to the tigecycline susceptibility of tetracycline-susceptible strains (MIC90, 0.5 μg/ml). The results provide a current (2002 to 2006) picture of the distribution of common tetracycline resistance determinants encoded in a globally sourced collection of clinical E. coli strains.
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Chebanenko, N. V., P. L. Sokol, and A. G. Prityko. "Congenital cerebral palsy with epilepsy: clinical and genetic comparisons." Russian Journal of Child Neurology 17, no. 3 (December 17, 2022): 43–54. http://dx.doi.org/10.17650/2073-8803-2022-17-3-43-54.

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Background. The problem of congenital cerebral palsy (CP) is relevant due to the limited complexity of habilitation and social adaptation of such patients. The genetic aspects of the pathogenesis of the disease are being actively studied. CP is often accompanied by epilepsy, which is characterized by refractoriness.Aim. To analyze the clinical, genetic and neuroimaging aspects of this pathology in CP patients.Materials and methods. The study included 136 patients with CP. Genetic studies were carried out on venous blood material using NGS and Sanger trio methods. The distribution of genes into groups of determinants was carried out.Results. In 136 patients, 91 genes with pathogenic variants were found. There were more of them in the determinant groups CS (regulation of cytoskeleton formation and functioning), ENM (regulation of neuronal membrane excitability), CMTR (control of chromatin modifications, transcription and replication processes), NTS (regulation of neurotransmitter metabolism and synapse functioning). The distribution of genes according to the degree of motor deficiency was specific: in all groups, except for canalopathy genes (ENM): certain genes corresponded to each degree of motor deficiency. This specificity was less pronounced in the ENM group. The largest number of cases of abnormalities in the structure of the brain was in the CMTR (control of chromatin modifications, transcription and replication processes), CS (regulation of the formation and functioning of the cytoskeleton) and ENM (regulation of the excitability of the neuronal membrane) groups. The RMF group (regulation of the functions of the mitochondrial apparatus) was characterized by the highest resistance to epilepsy. In cases from the group with the canalopathy genes (ENM), the epileptic process was not the most refractory.Conclusions. According to the contribution to the pathogenesis of CP with epilepsy, the distribution of determinants for the provision of excitability and conduction of the nervous tissue (ENM and NTS), the regulation of neuroontogenesis processes (NOG and CMTR), and the predetermination of enzymatic defects leading to storage diseases (GSD) are permissible. The determinant ENM is responsible for both the formation of motor deficits and the formation of the epileptic process. At the same time, its influence on motor deficit is nonspecific, and the degree of refractoriness of the epileptic process largely determines the determinant of mitochondrial function regulation.
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Hamdanillah, Rela, Anom Suardika, Made Darmayasa, and Ida Bagus Gde Fajar Manuaba. "Faktor determinan kematian ibu di RSUP Sanglah Denpasar tahun 2016." Intisari Sains Medis 11, no. 3 (December 1, 2020): 1075–80. http://dx.doi.org/10.15562/ism.v11i3.249.

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Background: Maternal mortality is the death of women during pregnancy or within 42 days of delivery, whether associated with pregnancy or complications exacerbated by pregnancy and not related to incidental causes. Maternal mortality is a critical indicator in assessing the level of wellbeing and public health status. The risk of maternal death is divided into three such as remote determinants, intermediate determinants, and acute clinical determinants.Aim: This study aims to determine the determinant factors as a role player in maternal mortality at Sanglah Hospital Denpasar in 2016.Method: This research is cross-sectional descriptive research conducted at RSUP Sanglah Denpasar. The sample of the study was all mothers died at Sanglah Hospital during the year 2016. The data obtained in the form of patient medical record data. Data were analyzed by descriptive methods.Result and Conclusion: The maternal mortality caused by the remoted determinant factors which were the highest in the maternal group with 9-12 years of education (77.3%) and the working mother group (54.5%). On the intermediate determinant, the highest is at age 20-35 years (81.8%), with parity 2-3 (63.6%), 2-10 year of gestational distance (54.5%), the most top obstetric factors are preeclampsia/eclampsia (27.2%), but the nonobstetric cause is the leading cause of maternal mortality. Kematian ibu adalah kematian wanita selama masa kehamilan atau dalam kurun waktu 42 hari setelah melahirkan, baik yang berhubungan dengan kehamilan maupun komplikasi yang diperburuk oleh masa kehamilan, serta tidak berhubungan dengan penyebab incidental. Angka kematian ibu merupakan indikator penting dalam menilai tingkat kesejahteraan dan status kesehatan masyarakat. Faktor yang berkontribusi terhadap kematian ibu secara garis besar dapat kelompokkan menjadi penyebab obstetrik dan penyebab non obstetrik. Menurut McCarthy dan Maine, risiko kematian ibu dibagi menjadi 3 yaitu, determinan jauh, determinan antara dan determinan dekat.Tujuan: Untuk mengetahui faktor-faktor determinan yang berperan dalam kematian ibu di RSUP Sanglah Denpasar tahun 2016.Metode: Penelitian ini merupakan penelitian deskriptif cross-sectional yang dilakukan di RSUP Sanglah Denpasar. Sampel penelitian adalah semua ibu meninggal di RSUP Sanglah selama tahun 2016. Data yang diperoleh berupa data rekam medis pasien, kemudian dianalisis secara deskriptif.Hasil dan Kesimpulan: Kematian ibu yang disebabkan karena faktor determinan yang tertinggi yaitu pada kelompok ibu dengan pendidikan 9-12 tahun (36,4%) dan kelompok ibu yang bekerja (54,5%). Pada faktor determinan antara yang tertinggi yaitu pada usia 20-35 tahun (81,8%), dengan paritas 2-3 (63,6%), jarak kehamilan 2-10 tahun (54,5%), faktor penyebab obstetrik yang tertinggi adalah preeklampsia/eklampsia (27,2%), namun secara garis besar penyebab non obstetrik merupakan penyebab utama kematian ibu.
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McFarland, Hugh I., Adrian A. Lobito, Michele M. Johnson, Jeffrey T. Nyswaner, Joseph A. Frank, Gregory R. Palardy, Nancy Tresser, et al. "Determinant Spreading Associated with Demyelination in a Nonhuman Primate Model of Multiple Sclerosis." Journal of Immunology 162, no. 4 (February 15, 1999): 2384–90. http://dx.doi.org/10.4049/jimmunol.162.4.2384.

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Abstract Definition of the immune process that causes demyelination in multiple sclerosis is essential to determine the feasibility of Ag-directed immunotherapy. Using the nonhuman primate, Callithrix jacchus jacchus (common marmoset), we show that immunization with myelin basic protein and proteolipid protein determinants results in clinical disease with significant demyelination. Demyelination was associated with spreading to myelin oligodendrocyte glycoprotein (MOG) determinants that generated anti-MOG serum Abs and Ig deposition in central nervous system white matter lesions. These data associate intermolecular “determinant spreading” with clinical autoimmune disease in primates and raise important issues for the pathogenesis and treatment of multiple sclerosis.
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Maeland, Johan A., Lars Bevanger, and Randi Valsoe Lyng. "Immunological Markers of the R4 Protein of Streptococcus agalactiae." Clinical Diagnostic Laboratory Immunology 12, no. 11 (November 2005): 1305–10. http://dx.doi.org/10.1128/cdli.12.11.1305-1310.2005.

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ABSTRACT This study focuses on immunological markers of R4, an important Streptococcus group B (GBS) protein. The results obtained by using rabbit antisera and purified proteins for antigens in enzyme-linked immunosorbent assay-based experiments provided evidence that R4 possesses two antigenic determinants. One of the determinants is shared with the alpha-like protein 3 (Alp3) of GBS, was named R4/Alp3 common, and was expressed by GBS, which possessed the Alp3-encoding gene alp3 or the R4-encoding gene rib. The other antigenic determinant was detected only in rib-positive GBS organisms and was named R4 specific. This determinant probably is an immunological marker unique to the R4 protein. Neither of the antigenic R4 determinants showed serological cross-reactivity with the GBS proteins Cα, Cβ, and R3 or with alpha-like protein 2. Of 60 clinical serotype III GBS strains, 56 (93%) isolates possessed the rib gene and 50 (89%) of the rib-positive isolates expressed levels of R4 detectable by antibody-based tests, consistent with R4 expression failure or low-level expression in ∼10% of rib-positive GBS. alp3 was not detected in type III GBS but was possessed by six of eight type V strains and six of six type VIII strains. All alp3-positive strains were recognized by the R4/Alp3 common antibodies, but none of them were recognized by the R4-specific antibodies. NCTC 9828, a reference strain for R3 and R4, expressed the determinant R4/Alp3 common but not R4 specific. A monoclonal R4 antibody, previously considered to be R4 specific and used in GBS serotyping, targeted R4/Alp3 common and is thus not R4 specific. The results show that failure to discriminate between R4 specific and R4/Alp3 common by antisera designed for GBS serotyping can result in the false identification of Alp3 as R4 or vice versa, whereas anti-R4 antibodies targeting only the determinant R4 specific will detect only R4. Both R4 and Alp3 need further evaluation with respect to the immunobiological function of each distinct antigenic determinant, for instance, with regard to their potential as GBS vaccine components.
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He, Xiaoye, Stephen J. Clarke, and Andrew J. McLachlan. "Clinical Pharmacology of Chemotherapy Agents in Older People with Cancer." Current Gerontology and Geriatrics Research 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/628670.

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Populations around the world are aging, and the associated increase in cancer incidence has led to the recognition of the importance of geriatric oncology. Chronological age is a poor determinant of pharmacological response to cancer chemotherapy agents. Age-associated changes in physiology and organ function have a significant impact on the clinical pharmacology of cancer chemotherapy agents used in cancer treatment. Altered response to medicines in older people is a consequence of changes in body composition, organ function, concomitant pathophysiology, multiple medications, genetic determinants of drug response, and patient's clinical status. These issues highlight the need to individualize the management of cancer in the older people with consideration of age-related changes in the clinical pharmacology of cancer drugs, analgesics, and adjunctive therapies.
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Dissertations / Theses on the topic "Clinical determinant"

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Páscoa, Carla Assunção Parreira. "Adesão à terapêutica como determinante da efectividade dos cuidados de saúde : A problemática da não adesão à terapêutica em doentes submetidos a angioplastia transluminal percutânea coronária." Master's thesis, Universidade de Évora, 2010. http://hdl.handle.net/10174/20840.

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A não adesão à terapêutica é determinante do aumento de taxas de morbilidade e de mortalidade dos doentes e de perturbações e gastos financeiros das organizações de saúde. O presente estudo teve como objectivo identificar determinantes de não adesão à terapêutica antiagregante plaquetária em doentes que foram submetidos a angioplastia transluminal percutânea coronária. Participaram neste estudo duas amostras de doentes com características demográficas semelhantes mas que deferiam no seu comportamento de adesão. Como metodologia para a identificação das crenças dos doentes em relação à doença ao tratamento foi utilizada um entrevista semi-estruturada baseada nas dimensões do Modelo de Crenças de Saúde. Os resultados evidenciam diferenças entre os dois grupos em especial no que diz respeito a: conhecimento da situação clínica e do tratamento; benefícios/custo do tratamento; consequências; percepção de auto-eficácia e vulnerabilidade. Baseado nos resultados apontam-se pistas de intervenção para a melhoria da qualidade dos cuidados de saúde prestados a estes doentes, numa perspectiva de governança clínica. – ABSTRACT: Non-adherence to treatment prescription is determinant of morbidity and mortality and is associated to organizational problems and financial costs. This study aimed to identify determinants of non-adherence to patients with Percutaneous Transluminal Coronary Angioplasty. The sample was constituted by two groups of patients with similar demographic characteristics and with different adherence behaviour. As methodology we used a semi-structured interview based on the Health Belief Model. Results show differences between the two groups in dimensions as: knowledge about the clinical situation and the treatment; benefits/costs of the treatment; consequences of adherence behaviour; self-efficacy and vulnerability: Based on the results we present some contributions to the quality of care of these patients and doing so hope to contribute to better organization in health services.
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Spagnolo, Paolo. "Genetic determinants of clinical phenotypes of sarcoidosis." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498439.

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Yee, Leland Jonathan. "Determinants of hepatitis C virus clinical outcomes." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2003. http://researchonline.lshtm.ac.uk/1620410/.

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Hepatitis C virus (HCV) infection is characterized by a broad spectrum of clinical outcomes. An estimated 14%-46% of individuals exposed to HCV are able to clear the virus, while the other portion develops chronic (persistent) infections. Among the individuals with chronic HCV who are treated with interferon-based therapies, only a portion are able to experience sustained virological suppression. Similarly, a number of chronically infected individuals have autoimmune extrahepatic manifestations such as the presence of autoantibodies. The pathological mechanisms behind these phenomena are not known, but it is believed that host genetic factors may play a role. This thesis examines the hypothesis that host genetic factors may contribute to the diverse spectrum of HCV clinical outcomes. In addition, it examines the pathogenesis of antinuclear antibodies (ANA) in chronic HCV, and the effect of ANA positivity on the natural history of HCV. Correlations were observed between female gender and geographic location and ANA positivity. No relationships were observed for an effect of ANA positivity on response rates to interferon therapy. We observed a trend of ANA positivity with faster progression of HCV-related fibrosis, although this failed to achieve statistical significance. ANA-positive individuals tended to have more plasma cells in their liver than ANA-negative individuals. This study also observed a number of correlations between genotypes of the interferon induced genes encoding the myxovirus resistance 1 protein (MxA), 2'-5'oligo-adenylate synthase 1 (OAS-1), and protein kinase (PKR), as well as genes encoding cytotoxic T-lymphocyte antigen-4 (CTLA4), and inducible nitric oxide synthase (iNOS) (encoded by the NOS2A gene) with several outcomes including self-limiting versus chronic HCV infection, along with the response to interferon therapy. This study identified several factors to be correlated with ANA positivity in HCV. These factors may serve as future points for investigation by basic scientists understanding the mechanisms of HCV-mediated autoimmunity. Importantly, this study suggests that low titre ANA positivity should not be a contraindication to therapy. This study also highlighted the importance of several genetic pathways in HCV infection. These may serve as targets for future pharmacologic interventions or genetic tests designed to screen for those who will not benefit from interferon therapies.
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Liu, Yiyuan. "Clinical and genetic determinants of diabetic retinopathy." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/5ac68285-0104-489d-9aad-c4b5dc15084f.

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Diabetic retinopathy is a microvascular complication of type 1 and type 2 diabetes, affecting the retinal vasculature of the eye. In the Scottish diabetic retinopathy grading scheme (version 1.1), the severity of diabetic retinopathy is classified as no retinopathy, mild background, observable background, severe non-proliferative and proliferative retinopathy. In the GoDARTS (Genetics of Diabetes Audit and Research Tayside) cohort, we have longitudinal data of retinopathy in diabetic patients since 1990. 3,734 and 3,673 GoDARTS patients were genotyped in the Affymetrix Genome-wide Human SNP Array 6.0 and Illumina HumanOmniExpress BeadChip, respectively. As the pathophysiology of diabetic retinopathy remains elusive, the aim of this thesis is to use the GoDARTS phenotype and genotype data to study clinical and genetic determinants for diabetic retinopathy.
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Erdkamp, Franciscus Louisa Gerardus. "Hodgkin's disease clinical and biological determinants of prognosis /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6570.

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Demjaha, Arsime. "Biological and clinical determinants of treatment resistant schizophrenia." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/biological-and-clinical-determinants-of-treatment-resistant-schizophrenia(eeabcaab-e9c7-4d41-99e6-8428569f57d0).html.

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Up to one third of patients with schizophrenia show only limited response to dopamine blocking antipsychotic medication. This could be due to distinct neurobiological abnormalities in this subgroup of patients. While there is robust evidence to suggest that the neurobiology of schizophrenia involves increased presynaptic striatal dopaminergic elevation, little is known as to whether this abnormality is present in treatment resistance, and consequently the relationship between this dopamine abnormality and the lack of response to treatment remains unknown. Furthermore, it remains unclear whether treatment resistance manifests at the outset of illness, and perhaps has a neurodevelopmental origin, or whether it evolves over time, possibly as a result of a neurodegenerative process. The first study in this thesis investigated striatal presynaptic dopamine synthesis in twelve treatment resistant schizophrenic patients, twelve patients with schizophrenia who had responded to antipsychotics, and twelve healthy volunteers, using [18F]-DOPA Positron Emission Tomography (PET). Thus, it was possible to test the hypothesis that the response to treatment is determined by differences in presynaptic dopamine function. The results demonstrated that there were no significant differences in striatal dopamine synthesis capacity between treatment resistant patients and healthy volunteers, whilst dopamine synthesis capacity was significantly increased in responders relative to treatment resistant patients. The difference was most marked in the associative and the limbic striatal subdivisions. A second, large follow-up study of first episode psychosis (FEP) patients, examined the course of treatment resistance over the 10 year follow up. It was found that over 80% of treatment resistant patients were persistently resistant from the initiation of antipsychotic treatment. My PET study, due to its cross sectional design, could not determine whether the normal dopamine levels predate the antipsychotic exposure in treatment resistant patients. However, by demonstrating that a great majority of treatment resistant patients are resistant to dopamine blocking antipsychotics at first ever initiation of treatment, my second study raises the possibility that these patients may have had normal dopamine levels even at the outset of their psychotic illness. In the same FEP cohort it was possible to investigate neurodevelopmental predictors of treatment resistance. The finding that the negative symptom dimension and younger age of onset were significant predictors of treatment resistance is compatible with the view that TRS may be of neurodevelopmental origin. Overall, my observations in this thesis indicate that TRS may be a distinct and enduring subtype of schizophrenic illness of a possible neurodevelopmental origin whose pathophysiology is not marked by alterations in dopamine synthesis capacity. Findings emerging from this thesis provide a platform for future studies, which may lead to the discovery of much needed new treatments for this disabling and intractable condition.
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Duperron, Marie-Gabrielle. "Genetic determinants and clinical significance of cerebral small vessel disease." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0449.

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La maladie des petites artères cérébrales (MPAC) constitue une étiologie importante d’accident vasculaire cérébral (AVC), de déclin cognitif et de démence. Les marqueurs en imagerie par résonance magnétique (IRM) de MPAC comprennent les hypersignaux de la substance blanche (HSB), les infarctus lacunaires (IL), les microsaignements (MS) et les espaces dilatés périvasculaires (EdPV). Une revue systématique et méta-analyse incluant plus de 16,000 participants a permis de mieux caractériser l’association des HSB, IL et MS avec le risque d’AVC et de démence, ainsi que leurs sous-types, et la mortalité. En raison de données limitées sur les EdPV dans cette revue systématique, nous avons étudié l’association entre les EdPV et le risque incident d’AVC au sein de la cohorte 3C-Dijon en population générale et avons mis en évidence une association significative des EdPV, en particulier au niveau des noyaux gris centraux et de l’hippocampe, avec le risque incident d’AVC, surtout hémorragique. Nous avons ensuite estimé l’héritabilité des EdPV à partir de génotypes pangénomiques, mettant en évidence une héritabilité plus élevée que pour les autres marqueurs IRM de MPAC, notamment pour les EdPV au niveau de la substance blanche. Dans un second temps, nous avons réalisé une méta-analyse d’études d’associations génétiques pangénomiques (GWAS) des EdPV qui nous a permis d’identifier 2 loci significativement associés au seuil pangénomique avec une sévérité plus importante des EdPV au niveau de la substance blanche. Ces associations orientent vers des gènes impliqués dans le développement cérébral, le fonctionnement des vaisseaux cérébraux et la tumorigenèse. Nous avons mis en évidence une corrélation génétique significative entre les EdPV au niveau des noyaux gris centraux et les AVC (tout type) et les AVC ischémiques. Enfin, nous avons étendu ces recherches à la cohorte Nagahama en population générale japonaise afin de (i) comparer la reproductibilité des 3 principales échelles visuelles de quantification des EdPV dans cette cohorte, et (ii) de réaliser un GWAS des HSB en population japonaise, qui a permis de confirmer dans cette population le locus du chr17q25.1 et d’identifier de nouveaux loci associés avec le volume d’HSB dans différentes régions du cerveau. En conclusion, nous avons apporté de nouveaux éléments sur la signification clinique des marqueurs IRM de MPAC, en particulier les EdPV, et sur les déterminants génétiques des marqueurs IRM de MPAC, avec une première estimation de l’héritabilité et une première méta-analyse de GWAS des EdPV, et un premier GWAS des HSB en population japonaise
Cerebral small vessel disease (cSVD) is a major cause of stroke, cognitive impairment and dementia. Magnetic resonance imaging (MRI) markers of cSVD comprise white matter hyperintensities (WMH), MRI-defined lacunes of presumed vascular origin (Lac), cerebral microbleeds (CMB) and dilated perivascular spaces (dPVS). A systematic review and meta-analysis on > 16,000 participants enabled to characterize the association of WMH, BI and CMB with risk of stroke and dementia, as well as their subtypes, and with mortality. Because of limited data on dPVS, we examined the longitudinal relationship of dPVS burden with incident stroke risk in the population-based 3C-Dijon study, and found a significant association between dPVS burden, especially in basal ganglia and hippocampus, and incident risk of any stroke and intracerebral hemorrhage. We then explored the heritability of dPVS burden using genome-wide genotypes and found highest heritability for dPVS burden compared with other MRI-markers of cSVD, especially in the white matter. Second we conducted a genome-wide association study (GWAS) meta-analysis of dPVS burden and identified two genome-wide significant loci associated with extensive dPVS burden in the white matter, implicated in brain development, brain vascular function and oncogenesis. We found significant genetic correlation of dPVS burden in basal ganglia with all stroke and ischemic stroke. Finally, we conducted an extension of this work in the Japanese Nagahama population-based study to: (i) compare the reproducibility of three dPVS visual rating scales (ii) conduct the first GWAS of WMH volume in a Japanese cohort, confirming the chr17q25.1 locus and identifying new loci associated with regional WMH volume. In conclusion, we provide novel information on the clinical significance of MRI-markers of cSVD, especially dPVS, and new insight into the genetic contribution to MRI-markers of cSVD, by conducting the first heritability assessment and GWAS meta-analysis of dPVS burden, and the first GWAS of WMH volume in a Japanese population
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Mikkola, R. (Reija). "Determinants and clinical implications of bleeding related to coronary artery bypass surgery." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526217390.

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Abstract Coronary artery bypass grafting (CABG) is the treatment of choice for patients with three-vessel disease or left main stenosis. However, it is associated with considerable risk of perioperative complications such as myocardial infarction, stroke, infections, and mortality to which excessive bleeding is a contributing factor. This thesis aims to determine the factors involved in and clinical implications of bleeding after CABG. The 1st study evaluated the effects of preoperative ASA discontinuation on the patient’s outcome after CABG. The results showed that late or no discontinuation of low-dose ASA before CABG may decrease the risk of postoperative stroke without increasing the risk of postoperative bleeding. In the 2nd study the use of warfarin was found to be a safe during CABG with no excess bleeding nor other major complications. The 3rd study estimated the impact of surgeons´ performances on blood loss and need for re-exploration after CABG. With 2001 study patients, this study clearly demonstrated that an individual surgeon is a powerful determinant of postoperative bleeding and need for re-exploration after CABG. Using systematic review and meta-analysis, we estimated the risk of complications related to re-exploration for bleeding after CABG. In literature search in 2011, 8 articles with 557 923 patients fulfilled the inclusion criteria. Re-exploration for bleeding after cardiac surgery carries a significantly increased risk of postoperative mortality and morbidity, and thus has a major impact on the patient’s immediate postoperative outcome. We also studied the impact of blood transfusion on the development of post-operative stroke after CABG. Of the study population of 2 226 CABG patients, stroke occurred postoperatively in 53 patients (2.4%). The statistical analysis showed that transfusion of blood products after CABG has a strong, dose-dependent association with the risk of stroke. The use of Octaplas® and platelet transfusions seem to have an even larger impact on the development of stroke than red blood cell transfusions. The 6th study investigated the impact of transfusion of blood products on intermediate outcome after CABG in 2001 patients. The findings indicated that transfusion of any blood product is associated with a significant risk of all-cause and cardiac mortality after CABG
Tiivistelmä Sepelvaltimotauti on yleisin kuolinsyy ja sepelvaltimoiden ohitusleikkaus hyvine pitkäaikaistuloksineen on todettu parhaaksi hoidoksi potilailla, joilla on monen suonen tai vasemman päärungon tauti. Ohitusleikkaukseen liittyy kuitenkin verenvuodon sekä näihin kytkeytyvien komplikaatioiden riski. Tämän väitöskirjan tavoitteena oli määrittää verenvuodon riskitekijöitä sekä verituotteiden siirtojen vaikutusta ohitusleikkauspotilaiden ennusteeseen. Verenhyytymistä estävien lääkkeiden tiedetään lisäävän verenvuotoja. Ensimmäinen tutkimus osoitti, että ASA:n jatkaminen keskeytyksettä ohitusleikkauksissa vähentää aivoinfarktien riskiä lisäämättä silti verenvuodon riskiä. Toisessa tutkimuksessa pitkäaikainen warfariinihoito osoittautui turvalliseksi ohitusleikkauksen aikana eikä sen käyttö lisännyt verenvuotoja eikä muita komplikaatioita. Kolmas tutkimus osoitti kirurgin taidon merkityksen verenvuotojen ja uusintaleikkausten määrään 2001 potilaalla. Verenvuotojen vuoksi tehtävien uusintaleikkausten negatiivinen vaikutus postoperatiiviseen mortaliteettiin sekä morbiditeettiin on todettu yksiselitteisesti useissa tutkimuksissa. Vuonna 2011 tehdyllä systemaattisella kirjallisuuskatsauksella ja meta-analyysillä selvitimme yhteensä 557 923 ohitusleikkauspotilaan aineistosta, että verenvuodon jälkeisiin uusintaleikkauksiin liittyy huomattava kuoleman ja komplikaatioiden riski. Verenvuotoja hoidetaan yleisesti verensiirroilla, vaikkakin useat tutkimukset ovat osoittaneet verituotteiden annon lisäävän mortaliteettia sekä komplikaatioriskiä. Viides tutkimus selvitteli sepelvaltimoleikkauksissa potilaalle annettujen verituotteiden ja leikkauksen yhteydessä sairastettujen aivoinfarktien välistä yhteyttä. Osoittautui, että verituotteiden käyttöön liittyy annosriippuvaisesti lisääntynyt riski saada aivoinfarkti leikkauksen yhteydessä. Varsinkin verihiutale- ja jääplasmasiirtoihin on todettu liittyvän vielä suurempi aivoinfarktin riski kuin punasolusiirtoihin. Kuudes tutkimus selvitteli sepelvaltimoleikkauksien yhteydessä annettujen verituotteiden vaikutusta 2001 potilaan keskipitkään ennusteeseen. Tutkimus osoitti, että minkä tahansa verituotteen antoon sepelvaltimoleikkauksissa liittyy lisääntynyt kuoleman ja sydänkuoleman riski
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McHenry, Michael Lyon. "Genomic and Co-Evolutionary Determinants of Clinical Severity in Active Tuberculosis Patients." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623754259445275.

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Dezfulian, Taryn M. "Determinants and behavioral correlates of state-level anxiety in clinical couple interactions." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2999.

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Thesis (M.S.) -- University of Maryland, College Park, 2005.
Thesis research directed by: Dept. of Family Studies. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Books on the topic "Clinical determinant"

1

Rashid, M. A. Determinants of utilization of satellite clinics. [Dhaka]: National Institute of Population Research and Training, 1992.

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Chassin, Mark R. How coronary angiography is used: Clinical determinants of appropriateness. Santa Monica, CA: Rand Corporation, 1987.

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Toornvliet, Arnoud C. Clinical determinants of weight loss in obese humans: Pharmacological and nutritional methods. [Leiden: University of Leiden], 1998.

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M, Eibl Martha, and Mayr W. R. 1944-, eds. Epitope recognition since Landsteiner's discovery: 100 years since the discovery of human blood groups. Berlin: Springer, 2002.

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1953-, Mutrie Nanette, ed. Psychology of physical activity: Determinants, well-being, and interventions. 2nd ed. Milton Park, Abingdon, Oxon: Routledge, 2007.

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Oddens, B. J. Determinants of contraceptive use: National population-based studies in various West European Countries = Determinanten van anticonceptiegebruik : nationale bevolkingsonderzoeken in enkele West Europese landen : een wetenschappelijke proeve op het gebied van de Medische Wetenschappen ; Proefschrift. Delft, Netherlands: Eburon, 1996.

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Gensini, Gian Franco, and Augusto Zaninelli, eds. Progetto RIARTE. Florence: Firenze University Press, 2015. http://dx.doi.org/10.36253/978-88-6655-906-1.

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Le malattie cardiovascolari rappresentano un’area clinica in cui maggiormente si avverte la necessità dello sviluppo di risposte assistenziali efficaci e sostenibili, nel cui ambito lo specialista deve svolgere un ruolo determinante, contribuendo a mettere in atto strategie gestionali condivise dalle diverse professionalità sanitarie e sostenute a livello istituzionale. I 200 casi clinici riportati dal progetto RIARTE sono, senza dubbio, una fotografia fedele, reale e pratica della realtà clinica in Italia per quanto attiene alle due categorie osservate: pazienti con rischio cardio e cerebrovascolare superiore al 20% secondo le tabelle del rischio SCORE e pazienti con ipertensione di difficile controllo. In entrambi i casi clinici l’adozione, nelle misure farmacologiche, della terapia a base di calcio-antagonisti diidropiridinici è apparsa efficace, sicura, di facile associazione con altre terapie e caratterizzata da un rapporto costo-efficacia particolarmente favorevole.
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Achkasov, Evgeniy, Andrey Pugaev, Maksim Zabelin, and Vladislav Posudnevskiy. Acute pancreatitis: clinic, diagnosis, treatment. ru: INFRA-M Academic Publishing LLC., 2019. http://dx.doi.org/10.12737/995531.

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The textbook consistently highlights the issues of anatomy and physiology of the pancreas, etiology, pathogenesis, classification, clinical picture, diagnosis and treatment of acute pancreatitis. Special attention is paid to determining the severity and prognosis of the disease. Modern approaches to treatment taking into account the severity of the disease, features of suppression of secretory activity of the pancreas and the role of nutritional support in the complex treatment of acute pancreatitis are presented. Attention is drawn to the timing of minimally invasive interventions for uninfected and infected postnecrotic fluid formations, as well as methods of surgical treatment in the phase of purulent-necrotic complications of acute pancreatitis. For the first time in the educational edition psychological aspects of rehabilitation of surgical patients are presented. Mastering the material of the textbook is facilitated by test tasks and questions for self-control. Meets the requirements of the Federal state educational standards of higher education of the last generation. It is intended for students of medical universities, clinical residents and doctors studying in the system of additional professional education, specialty "Surgery".
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Hasenfuss, G. Heart Rate as a Determinant of Cardiac Function: Basic Mechanisms and Clinical Significance. Steinkopff, 2012.

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Hasenfuss, G., and H. Just. Heart Rate As a Determinant of Cardiac Function: Basic Mechanisms and Clinical Significance. Steinkopff, Dietrich, 2012.

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Book chapters on the topic "Clinical determinant"

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Kumar, Vipin, and Eli Sercarz. "Self-Determinant Selection and Selective Regulation." In Selective Immunosuppression: Basic Concepts and Clinical Applications, 1–19. Basel: KARGER, 1994. http://dx.doi.org/10.1159/000319259.

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Deng, Lei, Shigaru Tatebe, Yen-Chiu Lin-Lee, Toshihisa Ishikawa, and M. Tien Kuo. "MDR and MRP Gene Families as Cellular Determinant Factors for Resistance to Clinical Anticancer Agents." In Cancer Treatment and Research, 49–66. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-1173-1_3.

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Reyneke, Johan P., and Carlo Ferretti. "Diagnosis and Planning in Orthognathic Surgery." In Oral and Maxillofacial Surgery for the Clinician, 1437–62. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-1346-6_66.

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AbstractThe clinical evaluation of the face is the most important aspect of evaluating patients with dentofacial deformities. The clinical examination is the primary determinant in making a diagnosis and developing a treatment plan. The basic treatment goals are: establishment of orofacial function, ensure stability of results, achieve facial esthetics and to consider the patency of the airway. The systematic clinical examination is divided into five basic evaluations: the frontal view, the profile view, three quarter view, an occlusal assessment and the temporomandibular joint evaluation. The clinical diagnosis is then confirmed with special investigations such as panoramic, lateral and anteroposterior cephalometric radiographs and other investigations as required. A dental, skeletal and soft tissue problem list is then noted and orthodontic and surgical solutions integrated into a final treatment plan. A cephalometric radiographic tracing or a 3D virtual treatment planning system is finally used to measure the planned surgical movements and to visualize the expected treatment results.
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Wheeler, Robert. "Determining Incapacity." In Clinical Law for Clinical Practice, 109–10. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429320583-46.

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Ramsey, Jon J. "Determining Energy Requirements." In Applied Veterinary Clinical Nutrition, 23–45. West Sussex, UK: John Wiley & Sons, Ltd., 2013. http://dx.doi.org/10.1002/9781118785669.ch3.

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Reach, Gérard. "Determinants and Explanatory Models of Clinical Inertia." In Clinical Inertia, 31–44. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09882-1_4.

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Giordano, Giulia M., Silvana Galderisi, Pasquale Pezzella, Andrea Perrottelli, and Paola Bucci. "Determinants of Clinical Recovery in Schizophrenia." In Recovery and Major Mental Disorders, 23–43. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-98301-7_2.

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Gayeski, T. E. "Principal Determinants of Tissue PO2: Clinical Considerations." In Update in Intensive Care and Emergency Medicine, 56–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84169-9_5.

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Schiffman, Jason, John Carter, Ricardo A. Machón, and Sarnoff Mednick. "Early Environmental Determinants of Schizophrenia." In Early Clinical Intervention and Prevention in Schizophrenia, 23–41. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-729-1_2.

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Jappe, U., and M. Raulf. "Cross-Reactive Carbohydrate Determinants: Diagnostic and Clinical Relevance." In Molecular Allergy Diagnostics, 91–108. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-42499-6_6.

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Conference papers on the topic "Clinical determinant"

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Sheng, Zhecheng. "NLP System for Mining Social Determinant of Health From Clinical Notes and its Fairness Evaluations." In 2022 IEEE 10th International Conference on Healthcare Informatics (ICHI). IEEE, 2022. http://dx.doi.org/10.1109/ichi54592.2022.00076.

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Owoyemi, Ayomide. "Development of a Determinant Framework to Guide the Translation of AI Systems in Clinical Care." In 2023 IEEE 11th International Conference on Healthcare Informatics (ICHI). IEEE, 2023. http://dx.doi.org/10.1109/ichi57859.2023.00079.

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Yeni, Yener N., Laila M. Poisson, and Michael J. Flynn. "Heterogeneity of Bone Mineral Density and Fatigue Failure of Human Vertebrae." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80908.

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Bone qualities that are measurable via clinically available modalities and that can explain fracture risk beyond what is explainable by bone mineral density (BMD) are of significant interest. Evidence from literature suggests that the heterogeneity of BMD within a vertebra, in addition to the average BMD, may be an important determinant of the mechanical properties of a vertebra 1–3 and risk of a clinical vertebral fracture 4. Much of the experimental evidence comes from tests, in which vertebrae are monotonically loaded and relates BMD heterogeneity to the quasi-static properties of a vertebra 1, 3. The appearance of clinical vertebral fractures is in the form of progressive deformities indicating that fatigue processes are involved. However, the relationships between BMD heterogeneity and fatigue properties of a vertebra are not well-understood.
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Wu, J., J. C. Brigham, M. A. Simon, K. Kim, and M. S. Sacks. "Geometric Analysis and Decomposition of Normal and Hypertensive Human Right Ventricle From Diagnostic Medical Imaging." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53951.

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Pulmonary hypertension (PH) is a cardio-pulmonary illness which affects all ages and racial populations, and induces significant changes to right ventricle (RV) shape and function. As such, the functional state of the RV is commonly thought to be a major determinant of symptoms and survival rates for PH. However, there has been little success to-date to identify clinically obtainable metrics of RV shape and deformation as a means to detect the onset and progression of PH. This difficulty is heightened by the complexity of RV shapes, which continues to confound basic and clinical scientists.
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Haddad, Peter, and Nilmini Wickramasinghe. "The Key Determinant Factors of Clinical Information Systems User Satisfaction: Lessons Learnt From an Australian Case Study." In Hawaii International Conference on System Sciences. Hawaii International Conference on System Sciences, 2018. http://dx.doi.org/10.24251/hicss.2018.382.

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Grist, Shelly, Abdul Hafeez-Baig, Raj Gururajan, and Shamim Khan. "Clinical Usefulness is the Key Common Determinant of Adoption of Wireless Technology in Healthcare for India and Australia." In International Conference on the Management of Mobile Business (ICMB 2007). IEEE, 2007. http://dx.doi.org/10.1109/icmb.2007.23.

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Su, Zhenbi, Kendall Hunter, Wei Tan, and Robin Shandas. "Influence of Distal Resistance and Proximal Vascular Stiffness on Vascular Impedance and Hemodynamics in Pulmonary Hypertension: A Computational Study With Validation Using an Animal Model." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204759.

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Clinically, invasive measurement of pulmonary vascular flow and pressure provides the hemodynamic status of the pulmonary circulation with pulmonary arterial hypertension (PAH). Current diagnostics and therapeutics for PAH revolve around pulmonary vascular resistance (PVR), which is determined by the mean pressure divided by mean flow [1]. Though PVR correlates well with right ventricular (RV) afterload, failure of which is the primary determinant of mortality [2–4], PVR does not provide the complete measure of RV afterload since it neglects dynamic impedance effects [4, 5]. Although we have shown that impedance predicts clinical outcomes better than PVR alone, several key questions remain about the relationship between hemodynamics and impedance changes in pulmonary hypertension.
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Su, Zhenbi, Kendall Hunter, and Robin Shandas. "Effect of Vascular Stiffness on Pulmonary Flow in Normotensive and Hypertensive States: Numerical Study With Fluid Structure Interaction." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192831.

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Invasive measurement of pulmonary vascular flow and pressure provides the hemodynamic status of the pulmonary circulation for children with pulmonary arterial hypertension (PAH). Clinicians are primarily interested in pulmonary vascular resistance, which is the mean pressure of the circuit divided by the mean flow through it [1], in that it is believed to well-quantify the right ventricular (RV) afterload, the primary determinant of mortality. However, previous and current investigations on the pulmonary vascular stiffness (PVS), input impedance and RV power [2–4] have found PVS to be an important contributor to power, and thus, afterload. These previous and current investigations focus on the analysis of clinical data, which is limited by the clinical equipment and techniques.
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Shah, Neha B., and John C. Bischof. "Effect of Surface Charge on Gold Nanoparticle Biotransport: An In Vivo Blood and Biodistribution Study." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53324.

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Intravenously injected nanoparticles (NPs) hold great promise for clinical diagnostic and therapeutic applications. While several NPs for such clinical applications have emerged in various designs (metallic, polymeric, quantum dots etc.) [1], a critical issue in their in vivo use is the lack of fundamental studies examining the effects of physicochemical parameters (shape, size, surface properties etc.) on blood circulation, kinetics of accumulation and elimination as well as toxicity [2–4]. We hypothesize that blood, the first medium of interaction in the body, is a major determinant of biotransport and biodistribution. Recent and past in vitro studies have shown that NPs interact with serum proteins (including complement factors), cause platelet aggregation and red blood cell hemolysis, and are taken up by phagocytic cells. However, to our knowledge a detailed in vivo study of the interaction of metallic nanoparticles with blood components as a function of their surface properties does not yet exist.
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Kayo, Munehiro Michael, and Yoshiaki Ohkami. "Structural Modeling of the Human Musculoskeletal System for Clinical Treatment by Applying Joint-Connected Multibody Dynamics and System Approach." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-40065.

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The objective of this paper is to establish a concise structural model of the human musculoskeletal system (HMS) that can be used to clinically treat malfunctions or distortions of the human body. This model must be uncomplicated for therapists to identify the problematic areas of the human body with adequate visualization while maintaining a theoretical thoroughness in mechanics. To achieve this objective, a system theory approach called the Interpretive Structural Modeling (ISM) has been applied to bridge multi-body dynamics and clinical observations. From a mechanical engineering viewpoint, this HMS system can be treated as a collection of joint connected 15 rigid bodies in a topological tree configuration with 35 Degrees-of-Freedom (DOF). Alternatively, from a clinical viewpoint, the functioning of the joints is a major concern since most malfunctions or distortions take place around the joints. Based on 20 years of accumulated clinical observation data, we have discovered that all HMS movements can be constructed by a combination of 35 fundamental motion elements, all having a certain degree of interaction with each other. By applying the ISM for a matrix representation of the HMS system, we have obtained the following results: 1) The association between the rotation of the joints and the fundamental motion elements is represented by a square matrix of dimension N, where N is twice of the DOF 2) The determinant of this matrix, corresponding to the N-square matrix in SE terminology, gives an evaluation criteria in selecting the fundamental elements; 3) Application of the ISM reveals a distinction between an active motion element with intention versus an associated motion element that is induced by another motion element(s). In addition, the ISM yields a tiered structure of the fundamental motion elements according to the degree of activeness; and 4) most important, an overall investigation of the matrix characteristics gives a means to identify imbalances or distortions within the HMS. With the help of a motion diagram for the purpose of visualization, this research can eventually be applied to clinical observations whereby an automated identification of malfunctioning parts can be achieved with computer software. The above stated results will contribute to a holistic and non-invasive approach for medical care and rehabilitation.
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Reports on the topic "Clinical determinant"

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Wang, Sin-Han, Elizabeth Evans, Ju-Seog Lee, and Shiaw-Yih Lin. Molecular Determinants and Clinical Implications of Breast Cancer Dormancy. Fort Belvoir, VA: Defense Technical Information Center, December 2014. http://dx.doi.org/10.21236/ada613720.

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Lin, Shiaw-Yih, Sih-Han Wang, and Ju-Seog Lee. Molecular Determinants and Clinical Implications of Breast Cancer Dormancy. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada598377.

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Solomon, Daniel, Nancy Shadick, and Elisabetta Patorno. Determining the Best Methods for Using Patient Registry Data in Clinical Research. Patient-Centered Outcomes Research Institute® (PCORI), September 2019. http://dx.doi.org/10.25302/9.2019.me.13035602.

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Gauker, Eleanor D., Paula J. Konoske, and Kristee Emens-Hesslink. Medical Planning for Operations Other Than War (OOTW): Determining Unique Patient Conditions Clinical Tasks and Supplies. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada421241.

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Grimes, William B. Determining the Optimal Operational Concept in the Orthopedic Clinic Using Simulation. Fort Belvoir, VA: Defense Technical Information Center, April 1998. http://dx.doi.org/10.21236/ada372087.

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Zaslavsky, Kirill, Jim Shenchu Xie, Hargun Kaur, Yasmin Motekalem, Yuri Chaban, and Edward Margolin. Efficacy of intra-arterial or intravenous thrombolytic therapy versus conservative standard therapy for central retinal artery occlusion: an individual patient data meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2023. http://dx.doi.org/10.37766/inplasy2023.5.0095.

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Review question / Objective: The primary aim of this systematic review and meta-analysis is to compare the efficacy of intra-arterial thrombolysis (IAT), intravenous thrombolysis (IVT), and conservative standard therapies (CST) for central retinal artery occlusion (CRAO) to better inform clinical practice. To this end, the proposed study will address the following question: which of the following interventions is the most effective at reducing severe vision loss in patients with CRAO: IAT, IVT, or CST? Secondary aims include determining an optimal time window for IAT and IVT in CRAO; comparing the prevalence of side effects between IAT, IVT, and CST; and determining whether patient comorbidities modify treatment outcomes to define particular subgroups in which thrombolytic therapy is significantly more beneficial (i.e. indicated) or harmful (i.e. contraindicated).
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Hassanein, Mohammed, Hasniza Huri, and Abduelmula R. Abduelkarem. Determinants of serum vitamin D and its metabolites and the reflection on vitamin D status in postmenopausal women: A systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0116.

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Review question / Objective: What are the factors that affect vitamin D metabolism and status in post-menopausal women? Condition being studied: Menopause: Menopause is defined as permanent cessation of menstruation resulting from loss of ovarian follicular activity. The occurrence of the last menstruation can only be diagnosed retrospectively and is usually taken as being final if it is followed by a 12-month bleed-free interval; such women are defined as being post-menopausal. Information sources: MEDLINE (by PubMed), Embase (by OvidSP), Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, Web of Science Core Collection, ClinicalTrials.gov, ISRCTN registry, EU Clinical Trials Register.
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Vélez, Rómulo Andrés, Alejandro Fereño Caceres, Wilson Daniel Bravo Torres, Daniela Astudillo Rubio, and Jacinto José Alvarado Cordero. Primary stability with the osseodensification drilling technique for dental implants in low density bone in humans: a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0066.

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Review question / Objective: - Does the osseodensification drilling technique increase primary stability in low-density bone? - The aim of the present investigation was to evaluate primary stability in dental implants in people with low density bone using the osseodensification technique. Condition being studied: The replacement of missing teeth through dental implants is currently the most practiced in dental clinics. The main criterion for determining the success of an implant is osseointegration, which is a direct structural and functional connection between vital bone and the prosthetic load-bearing surface of an implant. In the same way, primary stability must be obtained for a good lasting clinical result of the implant and to achieve this purpose, the bone density must be evaluated where the dental implant is to be placed. Salah Huwais in 2013 introduced a new osteotomy procedure (Oseodensification) for site preparation without removal and bone preservation. The Osseodensification process produces an autograft layer around the implant with the osteotomy surface, the autologous bone comes into contact through an endosteal device that accelerates osseointegration due to the nucleation of osteoblasts in the instrumented bone adjacent to the implant and has a greater primary stability due to contact between the device and the bone.
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De Vine, Ronald J. A Study to Develop and Apply a Model for Determining the True Costs of Performing a Specific Clinical Procedure at Naval Hospital Great Lakes. Fort Belvoir, VA: Defense Technical Information Center, August 1990. http://dx.doi.org/10.21236/ada238147.

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Petro Hernández, Victor Gerardo, María Adelaida Acosta Usta, and Angélica María Paul Blanco. Endoparasitosis en caninos y felinos domésticos en la clinica veterinaria UDES Valledupar. Universidad Nacional Abierta y a Distancia- UNAD, March 2023. http://dx.doi.org/10.22490/ecapma.5856.

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Contextualizamos el vínculo entre los animales y el ser humano favorece la aparición de enfermedades zoonóticas como infecciones parasitarias, Los hemoparásitos están entre los principales desafíos en la clínica médica medicina veterinaria, debido a los graves signos clínicos que provocan en los perros y gatos infectados. ¿Qué signos clínicos se pueden presentar? ¿puede un examen clínico dar solución a estos problemas? Los hemoparásitos están entre los principales desafíos en la clínica médica medicina veterinaria, debido a los graves signos clínicos que provocan en los perros y gatos infectados. Con el objetivo de determinar la prevalencia de enfermedades transmitidas por vectores y parasitosis gastrointestinal en caninos y felinos, mediante la revisión de fichas clínicas de pacientes que llegaron a la clínica veterinaria UDES Campus Valledupar. El presente trabajo tiene como metodología; durante los años 2019 y 2020 se realizó un estudio descriptivo de tipo retrospectivo, donde se recolecto información de la historia clínica de 95 caninos y 12 felinos domésticos como: raza, edad, sexo, peso, síntomas y signos clínicos, así como datos provenientes del cuadro hemático y examen coprológico. Los resultados obtenidos determinaron que la prevalencia de enfermedades parasitarias fue del 34,57%, los parásitos de mayor frecuencia en los exámenes hematológicos y coprológicos fueron el Anaplasma spp, Eimeria spp, y Ancylostoma spp; por lo que se hace necesario implementar acciones de educación sanitaria a la comunidad, elaborando planes de desparasitación, control y prevención haciendo uso adecuado de antiparasitarios y reducción de la contaminación ambiental, ya sea en perros y felinos de vida libre o con propietario.
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