Relevant bibliographies by topics / Clinical chemistry (incl. diagnostics)

Academic literature on the topic 'Clinical chemistry (incl. diagnostics)'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Clinical chemistry (incl. diagnostics)"

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Merkoçi, Arben. "Electroanalysis-Based Clinical Diagnostics." Electroanalysis 26, no. 6 (June 2014): 1110. http://dx.doi.org/10.1002/elan.201410132.

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Rej, Robert. "Clinical Chemistry through Clinical Chemistry: A Journal Timeline." Clinical Chemistry 50, no. 12 (December 1, 2004): 2415–58. http://dx.doi.org/10.1373/clinchem.2004.042820.

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Abstract The establishment of the modern discipline of clinical chemistry was concurrent with the foundation of the journal Clinical Chemistry and that of the American Association for Clinical Chemistry in the late 1940s and early 1950s. To mark the 50th volume of this Journal, I chronicle and highlight scientific milestones, and those within the discipline, as documented in the pages of Clinical Chemistry. Amazing progress has been made in the field of laboratory diagnostics over these five decades, in many cases paralleling—as well as being bolstered by—the rapid pace in the development of computer technologies. Specific areas of laboratory medicine particularly well represented in Clinical Chemistry include lipids, endocrinology, protein markers, quality of laboratory measurements, molecular diagnostics, and general advances in methodology and instrumentation.
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Popp, R., M. Basik, A. Spatz, G. Batist, R. P. Zahedi, and C. H. Borchers. "How iMALDI can improve clinical diagnostics." Analyst 143, no. 10 (2018): 2197–203. http://dx.doi.org/10.1039/c8an00094h.

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Горбич, Ю. Л., И. А. Карпов, Н. В. Соловей, and О. А. Горбич. "Infective Endocarditis in the Current Clinical Practice." Клиническая инфектология и паразитология, no. 1 (April 16, 2020): 99–115. http://dx.doi.org/10.34883/pi.2020.9.1.009.

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Инфекционный эндокардит остается заболеванием с относительно высокой летальностью, достигающей в настоящее время 1520 среди установленных случаев. Летальность в большинстве случаев связана с отсутствием или поздней диагностикой заболевания. В статье освещены ключевые аспекты этиологии, возможности диагностики (в том числе ранней диагностики) инфекционного эндокардита. Клиническая картина заболевания крайне неспецифична и не позволяет установить этот диагноз. Модифицированные критерии Дьюка и эхокардиография остаются основой диагностики, однако новые методики визуализационной диагностики (позитронно-эмиссионная томография, многослойная компьютерная томография с ангиографией) расширяют возможности постановки диагноза в сложных случаях. Особое внимание уделено вопросам антимикробной терапии инфекционного эндокардита, приведены схемы эмпирической и этиотропной терапии у пациентов с естественными и протезированными клапанами, факторы риска грибкового эндокардита и практические особенности использования наиболее широко применяющихся антибиотиков. Обсуждены возможности профилактики инфекционного эндокардита, которая в настоящее время рекомендована для применения только при ряде инвазивных стоматологических вмешательств у пациентов высокого риска. Infective endocarditis (IE) remains a highly mortal disease with approximately 1520 of lethal outcomes among established cases. In the vast majority of cases mortality in IE patients is associated with missed or made only late in the disease course diagnosis. Key features of the infective endocarditis etiology and diagnostics (incl. early diagnostics) are highlighted in this article. Clinical picture of the disease is nonspecific and does not allow making a diagnosis. The modified Duke Criteria and echocardiography remain the cornerstones of the diagnosis, however the new imaging methods (positron-emission tomography, multislice computed tomography with angiography) enlarge diagnostic options in complex and tricky cases. Particular attention was paid for antimicrobial therapy of infective endocarditis. Recommendations for empiric and targeted therapy in patients with native and prosthetic valves, risk factors for fungal endocarditis and practical essentials for the most widely used antibiotics are included in the article. Prophylactic approaches for infective endocarditis are also discussed. Issued guidelines recommend antibiotic prophylaxis only in high-risk patients before selected invasive dentistry procedures.
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Berger, L. "Sigma diagnostics: pioneer of kits for clinical chemistry." Clinical Chemistry 39, no. 5 (May 1, 1993): 902–3. http://dx.doi.org/10.1093/clinchem/39.5.902.

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Naithani, Manisha, and Parduman Singh. "Teitz Textbook of Clinical Chemistry & Molecular Diagnostics." Medical Journal Armed Forces India 62, no. 2 (April 2006): 204. http://dx.doi.org/10.1016/s0377-1237(06)80079-1.

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Hellsten, E., J. Vesa, I. J�rvel�, T. P. M�kel�, P. Santavuori, and L. Peltonen. "Refined assignment of the infantile neuronal ceroid-lipofuscinosis (INCL) locus at 1p32 and the current status of prenatal and carrier diagnostics." Journal of Inherited Metabolic Disease 16, no. 2 (1993): 335–38. http://dx.doi.org/10.1007/bf00710277.

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Bertok, Tomas, Aniko Bertokova, Stefania Hroncekova, Erika Chocholova, Natalia Svecova, Lenka Lorencova, Peter Kasak, and Jan Tkac. "Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications." Chemosensors 9, no. 8 (August 4, 2021): 205. http://dx.doi.org/10.3390/chemosensors9080205.

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The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about PCa aetiology, alternative biomarkers available for PCa diagnostics besides prostate specific antigen and their biosensing. In particular, low molecular mass biomolecules (ions and metabolites) and high molecular mass biomolecules (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.
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Malhotra, Bansi D., and Asha Chaubey. "Biosensors for clinical diagnostics industry." Sensors and Actuators B: Chemical 91, no. 1-3 (June 2003): 117–27. http://dx.doi.org/10.1016/s0925-4005(03)00075-3.

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Belluzo, María, María Ribone, and Claudia Lagier. "Assembling Amperometric Biosensors for Clinical Diagnostics." Sensors 8, no. 3 (February 27, 2008): 1366–99. http://dx.doi.org/10.3390/s8031366.

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Dissertations / Theses on the topic "Clinical chemistry (incl. diagnostics)"

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Dawson, Amy. "Paper microfluidics for clinical diagnostics using colourimetric detection methods." Thesis, University of Hull, 2014. http://hydra.hull.ac.uk/resources/hull:10515.

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Microfluidics is a technology currently aiming to advance the medical devices currently available in the developing and developed world through simultaneously creating point-of-care devices which are “as good” or better than current methods at a cheaper production cost. To be able to diagnose diseases and infections quickly and affordably remains the aim of many researchers and the use microfluidics has advantages which plug this difficulty. However, one main gap in the research is to train users for these devices which give accurate results when compared to current methods. Described herein are three point-of-care devices which would not require specialist users and give no significantly different results from hospital methods. The aim of this project was to design, fabricate and use a microfluidic device made from filter paper as a cheaper alternative to current microfluidic devices already available. The creation of channels to direct the movement of fluid within the paper matrix was established by modifying a photolithography method, thereby providing hydrophilic channels surrounded by a hydrophobic barrier. A three dimensional device was constructed entirely from filter paper to incorporate the simultaneous removal, reduction and detection of iron(II) via bathophenanthroline detection for the determination of iron(II) levels in a patient, indicative of the nutritional state of the patient e.g. does the pateitn suffer from anaemia. This method was deemed accurate by comparing the results to a conventional laboratory method (spectrophotometer analysis) completed in a hospital pathology laboratory. No significant difference was observed between results received from the hospital and results found using the paper microfluidic device, 15 μM ± 0.6% SEM versus 15.5 μM ± 0.8% SEM respectively. Two paper devices were developed to allow a quick and reliable measurement assessment of a patient’s renal function. The first for urea, as a simple colour change for a high or low readout of urea levels in serum samples, e.g. ≥ 150 μg/mL then an orange/red colour would be seen on the paper device, indicative of renal failure ≤ 150 ug mL¯¹. The second device used the Jaffe reaction on filter paper as a dipstick assay. No significant difference was observed between results received from the hospital and results found using the paper device 3.92 ± 1.2% versus 3.88 mg mL¯¹ ± 0.6% respectively. These three devices fulfil the aims of the project outline by remaining simplistic to use and are cost effective in both the developing and developed world, whilst maintaining accuracy as seen in the results received from hospital pathology laboratories.
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Dehmer, Susanne. "Validation of Abbott Diagnostics turbidimetric cystatin C assay and enzymatic creatinine assay using the Architect c8000 analyzer." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105609.

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Objective: Estimation of glomerular filtration rate (GFR) is an important tool in the diagnosis and management of chronic kidney disease. Today creatinine is the most frequently used marker for kidney function though several studies indicate that cystatin C is a superior marker. The purpose of this study was to validate Abbott Diagnostics turbidimetric cystatin C assay and enzymatic creatinine assay.

Methods: The validation was performed by studies of CV for the two methods and correlations between the two and other available methods for assessing GFR. The stability of cystatin C at room temperature was also evaluated.

Results: Both methods showed good precision. The Abbott cystatin C assay generally gave lower values and thereby higher estimated GFRs than the correlated Gentian method. The Abbott enzymatic creatinine assay gave higher values than the correlated Jaffe method. Those results are generally unexpected, but in this study the cause is an automatically applied negative intercept used together with the Jaffe method. Cystatin C showed high stability when stored at room temperature.

Conclusions: Estimated GFRs tend to differ depending on the choice of method for analyzing cystatin C or creatinine and this study gives an overview of the range of variation. The study also enlightens the need for an international calibrator for the cystatin C methods presented by different manufacturers.

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Kresak, Adam M. "The Technological History of Immunohistochemical Methods and Applications in Clinical Cancer Diagnosis and Research." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1531755545522738.

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"Optimization and Ultimate Limitations for Immunoassay and Clinical Diagnostics." Doctoral diss., 2015. http://hdl.handle.net/2286/R.I.34796.

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abstract: Biological fluids, in particular blood plasma, provide a vital source of information on the state of human health. While specific detection of biomarker species can aid in disease diagnostics, the complexity of plasma makes analysis challenging. Despite the challenge of complex sample analysis, biomarker quantification has become a primary interest in biomedical analysis. Due to the extremely specific interaction between antibody and analyte, immunoassays are attractive for the analysis of these samples and have gained popularity since their initial introduction several decades ago. Current limitations to diagnostics through blood testing include long incubation times, interference from non-specific binding, and the requirement for specialized instrumentation and personnel. Optimizing the features of immunoassay for diagnostic testing and biomarker quantification would enable early and accurate detection of disease and afford rapid intervention, potentially improving patient outcomes. Improving the limit of quantitation for immunoassay has been the primary goal of many diverse experimental platforms. While the ability to accurately quantify low abundance species in a complex biological sample is of the utmost importance in diagnostic testing, models illustrating experimental limitations have relied on mathematical fittings, which cannot be directly related to finite analytical limits or fundamental relationships. By creating models based on the law of mass action, it is demonstrated that fundamental limitations are imposed by molecular shot noise, creating a finite statistical limitation to quantitative abilities. Regardless of sample volume, 131 molecules are necessary for quantitation to take place with acceptable levels of uncertainty. Understanding the fundamental limitations of the technique can aid in the design of immunoassay platforms, and assess progress toward the development of optimal diagnostic testing. A sandwich-type immunoassay was developed and tested on three separate human protein targets: myoglobin, heart-type fatty acid binding protein, and cardiac troponin I, achieving superior limits of quantitation approaching ultimate limitations. Furthermore, this approach is compatible with upstream sample separation methods, enabling the isolation of target molecules from a complex biological sample. Isolation of target species prior to analysis allows for the multiplex detection of biomarker panels in a microscale device, making the full optimization of immunoassay techniques possible for clinical diagnostics.
Dissertation/Thesis
Doctoral Dissertation Chemistry 2015
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(6597242), Clint M. Alfaro. "DEVELOPMENT OF AMBIENT IONIZATION MASS SPECTROMETRY FOR INTRAOPERATIVE CANCER DIAGNOSTICS AND SURGICAL MARGIN ASSESSMENT." Thesis, 2019.

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Advancements in cancer treatments have increased rapidly in recent years, but cures remain elusive. Surgical tumor resection is a central treatment for many solid malignancies. Residual tumor at surgical margins leads to tumor recurrence. Novel tools for assessing residual tumor at surgical margins could improve surgical outcomes by helping to maximize the extent of resection. Ambient ionization-mass spectrometry (MS) methods generate and analyze ions from minimally prepared samples in near-real-time (e.g. seconds to minutes). These methods leverage the high sensitivity and specificity of mass spectrometry for analyzing gas phase ions and generating those ions quickly and with minimal sample preparation. Recent work has shown that differential profiles of ions, corresponding to phospholipids and small metabolites, are detected from cancerous and their respective normal tissue with ambient ionization-MS methods. When properly implemented, ambient ionization-MS could be used to assess for tumor at surgical margins and provide a molecular diagnosis during surgery.

The research herein reports efforts in developing rapid intraoperative ambient ionization-MS methods for the molecular assessment of cancerous tissues. Touch spray (TS) ionization and desorption electrospray ionization (DESI) were utilized to analyze kidney cancer and brain cancer.

As a demonstration of the applicability of TS-MS to provide diagnostic information from fresh surgical tissues, TS-MS was used to rapidly analyze renal cell carcinoma and healthy renal tissue biopsies obtained from human subjects undergoing nephrectomy surgery. Differential phospholipid profiles were identified using principal component analysis (PCA), and the significant ions were characterized using multiple stages of mass spectrometry and high resolution/exact mass MS. The same TS-MS analyzed renal tissues were subsequently analyzed with DESI-MS imaging to corroborate the TS-MS results, and the significant DESI-MS ions were also characterized with MS.

Significant efforts were made in developing and evaluating a standalone intraoperative DESI-MS system for analyzing brain tissue biopsies during brain tumor surgery. The intraoperative DESI-MS system consists of a linear trap quadrupole mass spectrometer placed on a custom-machined cart that contains all hardware for operating the mass spectrometer. This instrument was operated in the neurosurgical suites at Indiana University School of Medicine to rapidly analyze brain tissue biopsies obtained from glioma resection surgeries. A DESI-MS library of normal brain tissue and glioma was used to statistically classify the brain tissue biopsies collected in the operating room. Multivariate statistical methodologies were employed to predict the disease state and tumor cell percentage of the samples. A DESI-MS assay for detecting 2-hydroxyglutarate (2HG), the oncometabolic product of the isocitrate dehydrogenase (IDH) mutation (a key glioma prognostic marker), was developed and applied to determine the IDH mutation status during the surgical resection. The strengths, weaknesses, and areas of future work in this field are discussed.

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Books on the topic "Clinical chemistry (incl. diagnostics)"

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Kiyoshi, Miyai, Kanno Takashi 1936-, and Ishikawa Eiji 1933-, eds. Progress in clinical biochemistry: Proceedings of the 5th Asian-Pacific Congress of Clinical Biochemistry, September 29-October 4, 1991, Kobe, Japan. Amsterdam: Excerpta Medica, 1992.

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Burtis, Carl A., and David E. Bruns. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Elsevier - Health Sciences Division, 2014.

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Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Elsevier - Health Sciences Division, 2014.

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Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Elsevier - Health Sciences Division, 2017.

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1926-, Tietz Norbert W., Burtis Carl A, Ashwood Edward R. 1953-, and Bruns David E. 1941-, eds. Tietz textbook of clinical chemistry and molecular diagnostics. 4th ed. St. Louis, Mo: Elsevier Saunders, 2006.

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Burtis, Carl A., Edward R. Ashwood, and David E. Bruns. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. Saunders, 2005.

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Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Saunders, 2011.

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Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. Elsevier - Health Sciences Division, 2018.

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Burtis, Carl A., Edward R. Ashwood, and David E. Bruns. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book. Elsevier - Health Sciences Division, 2011.

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P, Patrinos George, and Ansorge Wilhelm 1944-, eds. Molecular diagnostics. Amsterdam: Elsevier Academic Press, 2005.

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Book chapters on the topic "Clinical chemistry (incl. diagnostics)"

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van den Broek, Daan, Eric Vermeer, Dorine Swinkels, and Ron H. N. van Schaik. "Molecular Diagnostic Testing in Clinical Chemistry." In Molecular Diagnostics, 131–54. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4511-0_7.

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Thiele, H. J., and W. Dummler. "Management and Organization of Clinical Chemistry and Laboratory Diagnostics in GDR." In Clinical Chemistry, 471–79. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0753-2_48.

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Ceglarek, Uta, Georg Martin Fiedler, and Joachim Thiery. "Applications of LC-MS/MS in Clinical Laboratory Diagnostics." In Analytical Techniques for Clinical Chemistry, 507–34. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118271858.ch18.

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Rodríguez, Blanca A. G., Paula A. B. Ferreira, and Rosa Fireman Dutra. "Impedimetric Immunosensors for Clinical Practices: Focus on Point-of-Care Diagnostics." In Tools and Trends in Bioanalytical Chemistry, 283–304. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82381-8_15.

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Schueler, Paula A., David L. Enfield, Tom M. Fleck, John T. Kingsley, and Walter C. Mahoney. "The Eclipse ICA®: An Immunochemical and Clinical Chemistry Assay System for Near-Patient Testing." In Diagnostics in the Year 2000, 177–96. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-6976-9_11.

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Vasudevan, DM. "Chapter-11 Molecular Diagnostics." In Clinical Chemistry Made Easy�, 327–40. Jaypee Brothers Medical Publishers (P) Ltd., 2011. http://dx.doi.org/10.5005/jp/books/11362_11.

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Justino, Celine I. L., Armando C. Duarte, and Teresa A. P. Rocha-Santos. "Immunosensors in Clinical Laboratory Diagnostics." In Advances in Clinical Chemistry, 65–108. Elsevier, 2016. http://dx.doi.org/10.1016/bs.acc.2015.10.004.

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Hirshman, B. R., R. T. Kras, J. C. Akers, B. S. Carter, and C. C. Chen. "Extracellular Vesicles in Molecular Diagnostics." In Advances in Clinical Chemistry, 37–53. Elsevier, 2016. http://dx.doi.org/10.1016/bs.acc.2016.05.005.

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Pingarrón, J. M., S. Campuzano, A. González-Cortés, and P. Yáñez-Sedeño. "Electrochemical Immunosensors for Clinical Diagnostics." In Encyclopedia of Interfacial Chemistry, 156–65. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-409547-2.13495-x.

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Trier, Nicole H., and Gunnar Houen. "Peptide Antibodies in Clinical Laboratory Diagnostics." In Advances in Clinical Chemistry, 43–96. Elsevier, 2017. http://dx.doi.org/10.1016/bs.acc.2017.01.002.

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Conference papers on the topic "Clinical chemistry (incl. diagnostics)"

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Baybuz, L. A., N. G. Perevalova, and V. Y. Makarov. "THE EFFECTIVENESS OF OZONE THERAPY IN THE REHABILITATION OF PATIENTS WITH DISORDERS OF THE CENTRAL NERVOUS SYSTEM AFTER SUFFERING COVID-ASSOCIATED PNEUMONIA." In The 16th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2021). FSBSI “IRIOH”, 2021. http://dx.doi.org/10.31089/978-5-6042929-2-1-2021-1-54-58.

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Abstract: The consequences of the transferred new coronavirus infection are currently not well understood, but the neurotropicity of SARS-CoV-2 is beyond doubt. In the manifestations of postcoid syndrome, damage to the central nervous system is dominant and requires timely diagnosis and correction, incl. at the rehabilitation stage of medical care. The introduction of highly effective non-drug methods of treatment with a small number of side effects is an urgent task of modern medicine. Such methods of treatment can include ozone therapy - the use of an ozone-oxygen mixture (ACS) for therapeutic purposes, which significantly improves blood microcirculation and oxygenation of ischemic tissues due to its fibrinolytic activity and antiaggregatory properties, and therapeutic doses of ozone are able to correct the lipid profile of patients due to reducing atherogenic lipoproteins, triglycerides and cholesterol. In the range of therapeutic concentrations, ozone exhibits immunomodulatory, anti-inflammatory, bactericidal, antiviral, and detoxification effects. This article presents the experience of using ozone therapy in patients who have undergone covid-associated pneumonia (CT1-CT4) with postcoid syndrome and a predominant lesion of the central nervous system. The analysis of the dynamics of symptoms in a group of patients who underwent a course of ozone therapy in comparison with a group where ozone therapy was contraindicated is presented. The defeat of the central nervous system was represented by the following syndromes and symptoms, both individually and in combination: - cerebrasthenic syndrome, incl. anxiety, insomnia, decreased or lack of appetite, unstable mood background, weakness, fatigue - 94% - cerebral syndrome (headaches, constant "fog in the head", less often dizziness, decreased memory and attention, impaired sensitivity like anosmia, hyposmia) - 62%, incl. loss of memory and attention was observed in 42%, anosmia and hyposmia occurred in 11% of cases. The severity of certain symptoms was manifested depending on the age, the severity of the disease, the timing of the beginning of rehabilitation measures and the comorbid background. Diagnostics of the lesion of the central nervous system by coronavirus in patients was carried out by the methods of questioning complaints, dynamic observation, using the questionnaire for assessing the quality of life EQ-5D. In addition, in both groups of patients, the assessment of the severity of the main syndromes in points from 0 to 10 was carried out using a questionnaire at the beginning of the rehabilitation course and at the end of it. Evaluation of the results at discharge was carried out using the Pearson correlation coefficient. The use of an ozone-oxygen gas mixture in a comprehensive rehabilitation program for patients with postcoid syndrome and a predominant CNS lesion can reduce the intensity or completely stop cerebroasthenic and cerebral syndromes, completely restore taste and smell, and improve certain cognitive functions. This will improve the quality of life of patients, their social adaptation and reduce the drug load. The syndromic complex of CNS lesions, which remains in a certain volume, even after a comprehensive rehabilitation program with ozone therapy, indicates the need for long-term follow-up, clinical examination and medical rehabilitation of patients after a new coronavirus infection.
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Chakrabarty, Krishnendu. "Digital Microfluidics: Connecting Biochemistry to Electronic System Design." In ASME 2007 5th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2007. http://dx.doi.org/10.1115/icnmm2007-30158.

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Microfluidics-based biochips are revolutionizing high-throughput sequencing, parallel immunoassays, blood chemistry for clinical diagnostics, DNA sequencing, and environmental sensing. The complexity of microfluidic devices, also referred to as lab-on-a-chip, is expected to become significant in the near future due to the need for multiple and concurrent biochemical assays on multifunctional and reconfigurable platforms. This paper provides an overview of droplet-based “digital” microfluidic biochips. It presents early work on top-down system-level computer-aided design (CAD) tools for the synthesis, testing and reconfiguration of microfluidic biochips. These CAD techniques allow the biochip to concentrate on the development of the nano- and micro-scale bioassays, leaving assay optimization and implementation details to design automation tools.
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Lee, HeaYeon, and JuKyung Lee. "Advanced Biomimetic Nanodevice Using Nanotechnology Addressable Lipid Rafts Nanoarrays Toward Advanced Nanomaterials." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93286.

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In recent years, a new paradigm of nanobiomedical devices combining miniaturization and integration has been exploited in areas such as combinational chemistry, biotechnology, engineering, proteomics and clinical diagnostics. One of the critical issues in the development of nanobiomedical system is how to differentiate signal-to-noise ratio per very small amount of signal. Biocompatible integrated nanopattern requires the fabrication of appropriately designed nanomatrix for high sensitivity homogenous assays, which are capable of ultimately mimic the physiological environment. We reported the nanomatrix geometry of a well-oriented nanowell array derived from nanofabrication technology which can easily be employed for digital detection with a high S/N ratio, miniaturization, integrated assays and single molecule analysis. In this present, we describe a nano(submicro) array of tethered lipid bilayer raft membranes comprising a biosensing platform.
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