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1

Abrams, Jonathan. "Chronic Stable Angina." New England Journal of Medicine 352, no. 24 (2005): 2524–33. http://dx.doi.org/10.1056/nejmcp042317.

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2

Ohman, E. Magnus. "Chronic Stable Angina." New England Journal of Medicine 374, no. 12 (2016): 1167–76. http://dx.doi.org/10.1056/nejmcp1502240.

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3

Gupta, Vitull Kumar, Meghna Gupta, and Manpreet Singh Brar. "Chronic Stable Angina." Journal of The Association of Physicians of India 73, no. 4 (2025): 101. https://doi.org/10.59556/japi.73.0885.

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4

M Elshafae, Mohamed, Jehan H. Sabry, Mohamed A Salem, and Hanan M Elshafee. "MicroRNA-155 in patients with Chronic Stable Angina." Annals of Applied Bio-Sciences 4, no. 1 (2017): A74—A82. http://dx.doi.org/10.21276/aabs.2017.1383.

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5

&NA;. "Chronic stable angina pectoris." Inpharma Weekly &NA;, no. 1193 (1999): 4. http://dx.doi.org/10.2165/00128413-199911930-00006.

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6

Dalal, J. N., and A. C. Jain. "Chronic stable angina pectoris." Postgraduate Medicine 91, no. 4 (1992): 165–77. http://dx.doi.org/10.1080/00325481.1992.11701251.

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7

Thadani, Udho, and Asim Chohan. "Chronic stable angina pectoris." Postgraduate Medicine 98, no. 6 (1995): 175–88. http://dx.doi.org/10.1080/00325481.1995.11946093.

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8

Higginbotham, Michael B., Kenneth G. Morris, R. Edward Coleman, and Frederick R. Cobb. "Chronic stable angina monotherapy." American Journal of Medicine 86, no. 1 (1989): 1–5. http://dx.doi.org/10.1016/0002-9343(89)90002-8.

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9

Jawad, Evyan, and Rohit Arora. "Chronic Stable Angina Pectoris." Disease-a-Month 54, no. 9 (2008): 671–89. http://dx.doi.org/10.1016/j.disamonth.2008.06.009.

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10

Berra, Kathy, Barbara Fletcher, and Nancy Houston Miller. "Chronic stable angina: Addressing the needs of patients through risk reduction, education and support." Clinical & Investigative Medicine 31, no. 6 (2008): 391. http://dx.doi.org/10.25011/cim.v31i6.4927.

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Chronic stable angina (CSA) is one of the most common symptoms experienced by persons with heart disease. CSA is defined by the physical symptoms resulting from blockage of blood flow through the coronary arteries. Anginal symptoms generally occur as a result of increased demands for blood flow, such as with physical activity, eating a large meal, emotional upset or exposure to cold weather. Symptoms vary widely and can include discomfort in the chest, arms, back and jaw, shortness of breath and a sense of increased fatigue. Many patients with chronic stable angina do not describe their sympto
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11

&NA;. "Management of chronic stable angina." Inpharma Weekly &NA;, no. 1315 (2001): 3. http://dx.doi.org/10.2165/00128413-200113150-00004.

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12

BEATTIE, SALLY. "Management of Chronic Stable Angina." Nurse Practitioner 24, no. 5 (1999): 44???61. http://dx.doi.org/10.1097/00006205-199905000-00004.

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13

O'Toole, L. "Chronic stable angina: treatment options." BMJ 326, no. 7400 (2003): 1185–88. http://dx.doi.org/10.1136/bmj.326.7400.1185.

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14

Nash, David T., and Stephen D. Nash. "Ranolazine for chronic stable angina." Lancet 372, no. 9646 (2008): 1335–41. http://dx.doi.org/10.1016/s0140-6736(08)61554-8.

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15

Gamham, S. P., K. Gunawardena, U. Hauf-Zacharlou, and R. A. Blackwood. "Carvedilol in chronic stable angina." Clinical Pharmacology & Therapeutics 59, no. 2 (1996): 163. http://dx.doi.org/10.1038/sj.clpt.1996.152.

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16

Gupta, Prabha Nini, Praveen Velappan, Krishna Kumar Bhaskara Pillai, and Riyas Abdul Salam. "Re chronic stable angina guidelines." Indian Heart Journal 69, no. 1 (2017): 129–32. http://dx.doi.org/10.1016/j.ihj.2017.01.004.

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17

Walters, Michele Ann. "Management of Chronic Stable Angina." Critical Care Nursing Clinics of North America 29, no. 4 (2017): 487–93. http://dx.doi.org/10.1016/j.cnc.2017.08.008.

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18

Padala, Santosh K., Michael P. Lavelle, Mandeep S. Sidhu, et al. "Antianginal Therapy for Stable Ischemic Heart Disease." Journal of Cardiovascular Pharmacology and Therapeutics 22, no. 6 (2017): 499–510. http://dx.doi.org/10.1177/1074248417698224.

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Chronic angina pectoris is associated with considerable morbidity and mortality, especially if treated suboptimally. For many patients, aggressive pharmacologic intervention is necessary in order to alleviate anginal symptoms. The optimal treatment of stable ischemic heart disease (SIHD) should be the prevention of angina and ischemia, with the goal of maximizing both quality and quantity of life. In addition to effective risk factor modification with lifestyle changes, intensive pharmacologic secondary prevention is the therapeutic cornerstone in managing patients with SIHD. Current guideline
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19

Mesnier, Jules, Gregory Ducrocq, Nicolas Danchin, et al. "International Observational Analysis of Evolution and Outcomes of Chronic Stable Angina: The Multinational CLARIFY Study." Circulation 144, no. 7 (2021): 512–23. http://dx.doi.org/10.1161/circulationaha.121.054567.

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Background: Although angina is common in patients with stable coronary artery disease, limited data are available on its prevalence, natural evolution, and outcomes in the era of effective cardiovascular drugs and widespread use of coronary revascularization. Methods: Using data from 32 691 patients with stable coronary artery disease from the prospective observational CLARIFY registry (Prospective Observational Longitudinal Registry of Patients with Stable Coronary Artery Disease), anginal status was mapped each year in patients without new coronary revascularization or new myocardial infarct
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20

Trujillo, Toby C., and Paul P. Dobesh. "Traditional Management of Chronic Stable Angina." Pharmacotherapy 27, no. 12 (2007): 1677–92. http://dx.doi.org/10.1592/phco.27.12.1677.

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21

Wee, Yong, Kylie Burns, and Nicholas Bett. "Medical management of chronic stable angina." Australian Prescriber 38, no. 4 (2015): 131–36. http://dx.doi.org/10.18773/austprescr.2015.042.

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22

Staniforth, Andrew D. "Contemporary Management of Chronic Stable Angina." Drugs & Aging 18, no. 2 (2001): 109–21. http://dx.doi.org/10.2165/00002512-200118020-00004.

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23

&NA;. "Nicorandil beneficial in chronic stable angina." Inpharma Weekly &NA;, no. 1334 (2002): 14. http://dx.doi.org/10.2165/00128413-200213340-00027.

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24

&NA;. "Arginine beneficial in chronic stable angina?" Inpharma Weekly &NA;, no. 1326 (2002): 13. http://dx.doi.org/10.2165/00128413-200213260-00029.

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25

Wong, John B. "Myocardial Revascularization for Chronic Stable Angina." Annals of Internal Medicine 113, no. 11 (1990): 852. http://dx.doi.org/10.7326/0003-4819-113-11-852.

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26

Kaski, Juan-Carlos, Antonio Arrebola-Moreno, and Jason Dungu. "Treatment strategies for chronic stable angina." Expert Opinion on Pharmacotherapy 12, no. 18 (2011): 2833–44. http://dx.doi.org/10.1517/14656566.2011.634799.

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27

Messenger, John C., and John D. Carroll. "Outpatient Management of Chronic Stable Angina." Primary Care Case Reviews 1, no. 4 (1998): 168–80. http://dx.doi.org/10.1097/00129300-199801040-00003.

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28

Dixit, Deepali, and Katarzyna Kimborowicz. "Pharmacologic management of chronic stable angina." Journal of the American Academy of Physician Assistants 28, no. 6 (2015): 1–8. http://dx.doi.org/10.1097/01.jaa.0000465223.98395.45.

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29

Myers, G. Robert, and William S. Weintraub. "Medical therapies for chronic stable angina." Current Cardiovascular Risk Reports 2, no. 5 (2008): 350–58. http://dx.doi.org/10.1007/s12170-008-0063-7.

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30

Gorlin, Richard. "Treatment of chronic stable angina pectoris." American Journal of Cardiology 70, no. 17 (1992): G26—G31. http://dx.doi.org/10.1016/0002-9149(92)90022-q.

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31

Richard, C. "Refractory chronic stable angina-now what?" Clinical Cardiology 27, no. 7 (2004): 375–76. http://dx.doi.org/10.1002/clc.4960270701.

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32

Reichek, Nathaniel. "Nitroglycerin in chronic stable angina pectoris." American Journal of Cardiology 60, no. 15 (1987): H15—H17. http://dx.doi.org/10.1016/0002-9149(87)90545-5.

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33

Vadnais, David S., and Nanette K. Wenger. "Management Options in Chronic Stable Angina Pectoris: Focus on Ranolazine." Clinical Medicine. Therapeutics 1 (January 2009): CMT.S2214. http://dx.doi.org/10.4137/cmt.s2214.

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Chronic stable angina pectoris results from a fixed coronary arterial obstruction causing an imbalance between myocardial oxygen supply and demand. Current therapy aims to reduce cardiovascular events (vasculoprotective) thereby improving survival, and/or relieve ischemic symptoms (antianginal) thereby improving the quality of life. Vasculoprotective therapy consists of lifestyle modification, antiplatelet agents, lipid lowering therapy and angiotensin-converting enzyme (ACE) inhibitors. Conventional antianginal therapy for patients with chronic stable angina consists of beta-blockers, calcium
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34

Galderisi, M., A. Celentano, G. Mossetti, et al. "Effects of Nicardipine on Chronic Stable Effort Angina: a Non-Invasive Assessment." Journal of International Medical Research 16, no. 5 (1988): 349–58. http://dx.doi.org/10.1177/030006058801600504.

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The effects of 60 mg/day nicardipine hydrochloride were evaluated in a 4-week single-blind study on 12 patients with chronic stable effort angina. All patients completed the treatment with few reports of adverse effects. Nicardipine hydrochloride was effective in reducing the incidence of anginal attacks and consumption of glyceryl trinitrate. Treadmill exercise time, angina onset time and the time to 1 mm ST-segment depression were increased. The extent of ST-segment depression was reduced at maximum comparable exercise, with a reduced rate–pressure product and, at maximum exercise, with an i
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35

Aldakkak, Mohammed, David F. Stowe, and Amadou K. S. Camara. "Safety and Efficacy of Ranolazine for the Treatment of Chronic Angina Pectoris." Clinical Medicine Insights: Therapeutics 5 (January 2013): CMT.S7824. http://dx.doi.org/10.4137/cmt.s7824.

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Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, β-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new d
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36

Pandrc, Milena, and Vanja Kostovski. "Antiischemic therapy in treating chronic coronary syndrome." Srpski medicinski casopis Lekarske komore 6, no. 2 (2025): 192–205. https://doi.org/10.5937/smclk6-58554.

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Myocardial ischemia is pathophysiologically based on the inadequate balance between the supply of oxygenated blood and the myocardial oxygen demand. Clinically, it presents as anginal pain with a typical localization, nature, intensity, and accompanying symptoms, primarily exercise intolerance. The diagnostic algorithm includes clinical examination, non-invasive and invasive diagnostic procedures, with coronary angiography as the gold standard. Conservative treatment of stable angina pectoris, in addition to lifestyle modification and elimination of traditional risk factors, involves the use o
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37

Tarkin, Jason M., and Juan Carlos Kaski. "Pharmacological treatment of chronic stable angina pectoris." Clinical Medicine 13, no. 1 (2013): 63–70. http://dx.doi.org/10.7861/clinmedicine.13-1-63.

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38

Maseri, A. "Medical therapy of chronic stable angina pectoris." Circulation 82, no. 6 (1990): 2258–62. http://dx.doi.org/10.1161/01.cir.82.6.2258.

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39

Thadani, Udho. "Current Medical Management of Chronic Stable Angina." Journal of Cardiovascular Pharmacology and Therapeutics 9, no. 1_suppl (2004): S11—S29. http://dx.doi.org/10.1177/107424840400900103.

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40

Toutouzas, Konstantinos, Antonis Karanasos, Maria Drakopoulou, et al. "Percutaneous Coronary Intervention in Chronic Stable Angina." American Journal of the Medical Sciences 339, no. 6 (2010): 568–72. http://dx.doi.org/10.1097/maj.0b013e3181d673d7.

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41

Staniforth, Andrew D. "Evidence based treatment of chronic stable angina." International Journal of Cardiology 63, no. 1 (1998): 21–25. http://dx.doi.org/10.1016/s0167-5273(97)00286-6.

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42

Bundy, Christine, Douglas Carroll, Louise Wallace, and Robert Nagle. "Psychological treatment of chronic stable angina pectoris." Psychology & Health 10, no. 1 (1994): 69–77. http://dx.doi.org/10.1080/08870449408401937.

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43

Holmes, David R., Bernard J. Gersh, Patrick Whitlow, Spencer B. King, and James T. Dove. "Percutaneous Coronary Intervention for Chronic Stable Angina." JACC: Cardiovascular Interventions 1, no. 1 (2008): 34–43. http://dx.doi.org/10.1016/j.jcin.2007.10.001.

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44

Krikler, Dennis M. "Calcium antagonists for chronic stable angina pectoris." American Journal of Cardiology 59, no. 3 (1987): B95—B100. http://dx.doi.org/10.1016/0002-9149(87)90088-9.

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45

Friedewald, Vincent E., Spencer B. King, Carl J. Pepine, George W. Vetrovec, and William C. Roberts. "The Editor’s Roundtable: Chronic Stable Angina Pectoris." American Journal of Cardiology 100, no. 11 (2007): 1635–43. http://dx.doi.org/10.1016/j.amjcard.2007.09.001.

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46

O'Rourke, Robert A. "Cost-effective management of chronic stable angina." Clinical Cardiology 19, no. 6 (1996): 497–501. http://dx.doi.org/10.1002/clc.4960190611.

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47

Richard Conti, C. "Medical device therapy for chronic stable angina." Clinical Cardiology 21, no. 2 (1998): 71. http://dx.doi.org/10.1002/clc.4960210202.

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48

Abbas, Eslam, Ahmed Mahdy, and Shady Mansy. "Relentless Angina of a Scarred Heart." Cardiology and Cardiovascular Research 8, no. 4 (2024): 92–95. https://doi.org/10.11648/j.ccr.20240804.11.

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Refractory anginal pain affects nearly 5-10% of stable coronary artery disease patients, and maximizing the anti-ischemic medical therapy is the standard first-line treatment. The presence of a scarred myocardial territory of the epicardial coronary chronic total occlusion (CTO) limits the implementation of other modalities, such as angioplasty and surgical bypass. Accordingly, this subset of patients, who show poor response to medical treatment with the absence of considerable reversible ischemia, bears an additional burden of persistent angina besides the structural and functional complicati
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49

Temnikova, E. A. "Pharmacological treatment of stable angina pectoris: the place of trimetazidine." Eurasian heart journal, no. 4 (December 20, 2022): 82–89. http://dx.doi.org/10.38109/2225-1685-2022-4-82-89.

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According to international epidemiological studies, the total number of reported cases of cardiovascular diseases (CVD) almost doubled from 1990 to 2019, reaching 523 million and the number of deaths from CVD in 2019 increased by more than 1.5 times (18,6 million). Coronary artery disease (CAD) and stroke are the main contributors to these unfavorable trends. The number of registered cases of coronary heart disease in 2019 amounted to 197 million, and the number of deaths caused by coronary artery disease exceeded half of all registered cases of cardiovascular death (9,14 million). Patients wi
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50

Arora, Rohit. "Utility of ranolazine in chronic stable angina patients." Vascular Health and Risk Management Volume 4 (August 2008): 819–24. http://dx.doi.org/10.2147/vhrm.s2841.

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