Journal articles on the topic 'Chronic renal failure Patients Family relationships'
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Darsini, Darsini. "Dukungan Keluarga Dengan Tingkat Depresi Pasien Gagal Ginjal Kronis Yang Menjalani Hemodialisa (Studi Korelasi Di Rumah Sakit Gatoel Mojokerto)." Jurnal Ilmu Kesehatan 4, no. 2 (June 14, 2017): 1. http://dx.doi.org/10.32831/jik.v4i2.83.
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Depression is a psychological effect that is common in patients with chronic health problems such as ESRD (End Stage Renal Disease). Depression is often associated with increased morbidity of the disease. The results of preliminary studies that the researchers did found that 85 of patients with chronic renal failure undergoing regular hemodialysis at Gatoel Hospital Mojokerto depressed. Strong support system can speed up recovery of depressive episodes. The purpose of this study to determine the relationship of family support with levels of depression chronic renal failure patients undergoing hemodialysis. The research is to the type of research corellation. The population in this study were patients with chronic renal failure undergoing hemodialysis at Gatoel Hospital Mojokerto by the number of samples taken by 30 respondents with technique thst is consecutive sampling. The results showed that the majority (90%) patients with chronic renal failure undergoing hemodialysis were depressed with the largest proportion is mild and moderate depression (40%). Judging from the absence of family support is known that most of the 53% get enaugh family support. Spearman Rank Test results of the analysis results obtained p = 0,020 ; α = 0,05, so Ha is received it means there is a relationships of family support with levels of depression chronic renal failure patients undergoing hemodialysis at Gatoel Hospital Mojokerto. Family support is an important form of support system for patients who are depressed. Family support appropriate and as required improved the lives an improve quality of live. Families can always be expected to provide support so that patients can develop coping mechanism and problem solving are effective. Keywords : Family Support, Depression, GGK, Hemodialysis
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Dessy, Diyan Ajeng,. "HUBUNGAN DUKUNGAN KELUARGA DENGAN TINGKAT KEPATUHAN PASIEN HEMODIALISA TERHADAP TERAPI GAGAL GINJAL DI RSUD BLAMBANGAN BANYUWANGI." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 1, no. 1 (January 27, 2021): 21–26. http://dx.doi.org/10.53864/jifakfar.v1i1.7.
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Chronic Renal Failure (CRF) is a chronic disorder of renal function is progressive and irreversible. In which the body fails to maintain metabolic and fluid and electrolyte balance, causing uremia and could eventually cause a disruption in the body's immune system. According Raharjo (1996) and Lopez (2006), the estimated number of patients with chronic renal failure continues to increase and the estimated growth of about 10% every year.This research design was a descriptive cross sectional study. Have done a study of 55 patients with chronic renal failure who had been treated at the Hospital Medicine at Blambangan, Banyuwangi in 2014 patient data information obtained from the patient visit checklist. This study was to determine the relationship of family support with chronic renal failure patient adherence to therapy in poly Haemodialysis Haemodialysis in hospital Blambangan, Banyuwangi in 2014.Research was obtained as many as 15 people (27.28%) patients with chronic renal failure aged 25-30 years, and 17 (30.9%) aged 41-50 years with a self-employed job and most of the heavy labor. Researchers hope that the hospitals can provide direction Blambangan Banyuwangi, in-depth knowledge about chronic kidney disease to patients and families of patients so that the family can fully support patient compliance in taking medication and undergoing therapy in a timely and appropriate.From the research, it was concluded that 9.1% of patients not adherent and 90.9% patient compliance with the treatment given by the hospitals Blambangan Banyuwangi.Keywords: Chronic Renal Failure, Hemodialysis, Family Support
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Petrovic, Lada, Igor Mitic, Dusan Bozic, Slavenka Vodopivec, and Tatjana Djurdjevic-Mirkovic. "Quality of life in patients with chronic renal failure." Medical review 59, no. 9-10 (2006): 411–14. http://dx.doi.org/10.2298/mpns0610411p.
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Introduction. Hemodialysis and transplantation are performed not only to replace renal function, but also to improve patients' quality of life. The aim of our investigation was to compare the quality of life in patients with chronic renal failure (CRF) before and after the introduction of active therapy. Material and methods. We tested 76 patients (pts): 20 pts on conservative therapy (CT), 21 pts on chronic hemodialysis and 35 pts with renal transplantation. A questionnaire (combining two questionnaires) was used to investigate the physical, emotional and social aspects of health. Results. In regard to physical health of transplantation patients (TP) it was established that work capacity and activities were less damaged, whereas physical activity was highest in pts on CT. Social activity was limited in a higher percentage in TP (40%) than in hemodialysis patients (HD) (19%), while family relationships were most damaged in pts on HD (28.57%). Discomforts were most common in pts on HD. The highest percentage of pts estimated their health status as good or average, but their health status improved after transplantation in 82.86% that is in 57.14% after HD. It was similar with the quality of life: 28.57% of kidney transplant patients rated their quality of life as very good, and 54.28% rated it as good; 38.09% of HD patients rated their quality of life as very good, whereas only 5% of CT patients rated it as very good, and 20% as good. .
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Sara Tania Aprianty, Sara, and Hani Siti Hanifatun Fajria. "THE RELATIONSHIP OF FAMILY SUPPORT REGARDING THE PATIENTS WITH CHRONIC KIDNEY FAILURE WHO HAVE HEMODIALIZED THERAPY TREATMENT IN PMI HOSPITAL BOGOR." Jurnal Ilmiah Wijaya 10, no. 2 (June 22, 2020): 80–88. http://dx.doi.org/10.46508/jiw.v10i2.52.
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Chronic Renal Failure (CRF) is a disease that has occurred after various diseases that damage the kidney nephrons period up to the point the two are not capable of functioning regulatory and ekstetoriknya to maintain homeostasis. Number of patients with kidney failure in Indonesia is estimated to reach 300.000 people. As many as 12.804 patients with renal failure undergoing hemodialysis. To determine correlation family support patient compliance with chronic renal failure undergo hemodialysis therapy in RS PMI Bogor. This type of research is descriptive quantitative analytical research with cross sectional design. How sampling in this study with purposive sampling with a sample of 152 respondents. The instrument used is questionnaire while data analysis techniques using univariate and bivariate analysis using statistical test Chi-Square. Of the 152 respondents with a family to support as many as 139 respondents (91.4%), adherent patients as many as 128 respondents (84.2%) and family support with adherent patients as many as 121 respondents (79.6%). Statistical test results using Chi-square test p value value 0,007 (p <0.05) and the value of OR 5.762. The conclusion of this research that, There is a correlation between family support patient compliance with chronic renal failure through hemodialysis therapy in PMI Hospital Bogor, 2016. The researchers recommend that increased family support by distributing leaflets to the patients and families about the importance of family support for compliance patients undergo hemodialysis therapy.
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Fajar Adhie Sulistyo. "THE RELATIONSHIP OF FAMILY SUPPORT WITH QUALITY OF LIFE AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE IN RUNNING HEMODIALIZATION THERAPY AT PMI HOSPITAL BOGOR." Jurnal Ilmiah Wijaya 10, no. 1 (February 1, 2018): 15–19. http://dx.doi.org/10.46508/jiw.v10i1.3.
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Background : Chronic kidney disease is a pathophysiological process with diverse etiology, resulting in a progressive decline in renal function, and the patients generally end up with kidney failure. Family support is a support given by families who have blood relations in favor of the health of patients with kidney failure. Quality of life is an individual perception of patients with kidney failure toward his position in life. The aim of this study was to determine the relationship of family support with the quality of life of patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. The method of this research uses uses descriptively analytic type with cross sectional approach. The sample of this researchconsists of 129 respondents. The sampling was taken by accidental sampling technique. The instrument in this study were questionnaires family support and quality of life. The data were analyzed by using univariate and bivariate (using the chi-square test with α = 0.05). Result : Based on the research results through 88 respondents that (68.2%) whose family support is good, then 86 respondents (93%) have a good quality of life, and 2 respondents (5%) have less quality of life. From 8 respondents (6.2%) whose family support is less, 1 respondent (2%) have a good quality of life, and 7 respondents (19%) have a less quality of life. Based on statistical test p = 0.000, it can be concluded that there is significant correlation between both variables. Clonclusion : It is concluded that there is a relationship between family support and the quality of life among patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. Through this research, it is expected to be used as a source reference of information for nurses in hemodialysis room.
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Basri, Basri. "HUBUNGAN PENGETAHUAN PASIEN GAGAL GINJAL KRONIK YANG MENJALANI TERAPI HEMODIALISISTERHADAP KEPATUHAN DIETDI RSI MALAHAYATI." Jurnal Maternitas Kebidanan 4, no. 2 (October 18, 2019): 25. http://dx.doi.org/10.34012/jumkep.v4i2.707.
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Knowledge and compliance are the key to health in patients with chronic renal failure undergoing hemodialysis therapy, a diet that is consumed in excess or less will cause side effects in patients, while patients with chronic renal failure often experience deficits in nutritional intake. The purpose of this study was to determine the relationship between the level of knowledge and level of dietary compliance in patients with chronic renal failure undergoing hemodialysis therapy in an Islamic hospital instead of terrain. The method used was an observational analytic population of all patients with chronic renal failure, all patients with chronic renal failure undergoing hemodialysis therapy at an Islamic hospital actually had a field of 33 patients using a total sample. Data collection used questionnaires, independent variables of knowledge and dependent variables on diet compliance. Data were analyzed with significance α = 0.05. The results of the study showed that most (72.7%) respondents had good knowledge and almost all respondents (93.9%) were obedient in dieting. The results of the analysis obtained are ρ = 0.011, ρ> 0.005 meaning that there is no significant relationship between knowledge and dietary compliance. Knowledge greatly affects adherence to a person's diet, there are other things that affect such as patient experience, social, economic conditions, patient psychological factors, and family support for patients. For patients with chronic kidney failure who undergo hemodialysis therapy should maintain their knowledge and also be able to advise patients who have recently undergone hemodialysis therapy from their past experience and for colleagues to always give enthusiasm and motivation to patients and provide support for knowledge and information.
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Ningrum, Windy Astuti Cahya, M. Rafiud Drajat, and Imardiani Imardiani. "DUKUNGAN KELUARGA DAN PENGETAHUAN DENGAN KEPATUHAN PEMBATASAN CAIRAN PASIEN GAGAL GINJAL KRONIK." Masker Medika 8, no. 1 (August 14, 2020): 146–56. http://dx.doi.org/10.52523/maskermedika.v8i1.387.
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Latar Belakang: Kegagalan fungsi ginjal dalam mempertahankan metabolisme keseimbangan cairan dan elektrolit merupakan kondisi yang dialami oleh pasien gagal ginjal kronik, keadaan ini mengakibatkan pasien perlu untuk mengontrol asupan cairan guna membantu mengurangi beban kerja ginjal dalam memproses cairan. Pembatasan cairan merupakan salah satu intervensi atau terapi dan faktor penting dalam menentukan keberhasilan terapi pasien gagal ginjal kronik, sehingga dibutuhkan kepatuhan pasien dalam terapi tersebut. Pengetahuan keluarga dan dukungan keluarga merupakan faktor yang dapat meningkatkan kepatuhan pasien dalam menjalani pembatasan cairan. Tujuan Penelitian: Mengetahui hubungan pengetahuan dan dukungan keluarga dengankepatuhan pembatasan cairan pasien gagal ginjal kronik. Metode Penelitian: Penelitian ini menggunakan jenis desain analitic korelasi melalui pendekatan cross sectional dengan teknik non probability sampling : total sampling yangdilaksanakan pada tanggal 10 April – 15 April dan didapatkan jumlah sampel 52 responden dengan menggunakan instrument penelitian kuesioner dan observasi.Hasil: Analisis uji chi square antara pengetahuan dengan kepatuhan pembatasan cairan didapatkan nilai p=0,012 dan dukungan keluarga dengan kepatuhan pembatasan cairan didapatkan nilai p=0,014.Kesimpulan: Ada hubungan yang signifikan antara pengetahuan dan dukungan keluarga dengan kepatuhan pembatasan cairan pasien gagal ginjal kronik di Ruang Hemodialisa RS PUSRI Palembang.
condition experienced by patients with chronic renal failure, this condition resulted in patients need to control fluid intake to help reduce the workload of the kidney in processing fluids. Fluid restriction is one of intervention or therapy and an important factor in determining the success of chronic renal failure therapy patients, so that patient's compliance is required in the therapy. Family knowledge and family support are factors that can improve patient compliance with fluid restrictions. Objective: To examine the relationship of knowledge and family support to fluid restriction adherence in patients with chronic renal failure. Method: This research use correlation analitic design type through cross sectional approach with non probability sampling technique: consecutive sampling and got sample number 52 respondents. Result: Analysis of chi square test between knowledge to fluid restriction compliance (p value = 0,012) and family support to compliance of fluid restriction (p value = 0,014). Conclusion: There is a significant relationship between knowledge and family support for fluid restrictioncompliance in patients with chronic renal failure in the Hemodialisa Room of PUSRI Palembang Hospital.
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Mulyadi, Mulyadi, and Almaini Almaini. "The Relationship between Regiousity and Family Support with Meaningfulness of Life of Chronic Kidney Failure’s Clients in Curup Hospital." Jurnal Sains Kesehatan 25, no. 2 (August 13, 2018): 31–38. http://dx.doi.org/10.37638/jsk.25.2.31-38.
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Basic medical research 2013 pointed to an increasing prevalence GGK by province in Indonesia in 2013, interviews doctor's diagnosis increases with age, the rose sharply in the age group 35-44 years (0.3%), was followed the age of 45-54 years (0.4%) and aged 55-74 years (0.5%) is the highest in the age group 75 years (0.6%). The study aims to know the relationship religiousity and family support to the meaningfulness life of patients with chronic renal failure undergoing hemodialysis. Design Analytical research using descriptive method with cross sectional approach. Samples are renal failure patients undergoing hemodialysis in hospitals Curup is counted many as 56 people. The results showed there significant relationship between religiutitas and family support to the meaningfulness life of patients. By increasing religiutitas family support will increase the motivation of patients in hemodialysis therapy. Keywords : CRF, haemodialysis, meaningfulness life, religiousity
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Mistik, Selcuk, Demet Unalan, Humeyra Aslaner, and Bulent Tokgoz. "Evaluation of Fatigue’s Effect and Severity in Hemodialysis Patients." Eurasian Journal of Family Medicine 11, no. 2 (June 30, 2022): 136–42. http://dx.doi.org/10.33880/ejfm.2022110208.
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Aim: In this study, it was aimed to evaluate the effect and severity of fatigue levels in hemodialysis patients. Methods: This cross-sectional study was conducted on 130 patients who applied to Hemodialysis units between 01 November-01 December 2019. Piper Fatigue Scale, Fatigue Impact Scale, and Fatigue Severity Scale were used as data collection tools. In statistical analysis, Student's t-test and variance analysis were used. Pearson correlation coefficient was calculated to evaluate the relationship between the variables. Results: It is found that hemodialysis patients got the highest score on Piper Fatigue Scale from Piper Fatigue Scale - Affect (5.48±2.85) and patients felt moderately tired. Of the patients, 43.1% stated that ‘dialysis’ was the most important reason that contributes directly or causes their fatigue, and 23.1% stated that the best thing they found to reduce their fatigue was to sleep. Hemodialysis patients got the highest score on the Fatigue Impact Scale from the psychosocial (35.42±18.67) effect dimension. The mean score of the patients' Fatigue Impact Scale was 4.84±1.93. The Piper Fatigue Scale - Behavior, Piper Fatigue Scale - Affective, Piper Fatigue Scale - Sensory and Piper Fatigue Scale - Cognitive Dimension Scores, Fatigue Impact Scale - Cognitive, Fatigue Impact Scale - Physical and Fatigue Impact Scale - Psychosocial Dimension and Fatigue Impact Scale Total Scores and Fatigue Severity Scale Scores in Chronic Renal Failure patients with a chronic disease were significantly higher than in patients without chronic disease. The Fatigue Impact Scale - Cognitive, Fatigue Impact Scale - Physical, and Fatigue Impact Scale - Psychosocial dimensions, Fatigue Impact Scale total scores, and Fatigue Severity Scale scores in patients diagnosed with anemia were significantly higher than in those without anemia. Conclusion: In our study, patients over 65 years of age and those with chronic diseases other than Chronic Renal Failure had higher levels and greater impact and severity of fatigue. Keywords: dialysis, fatigue, severity, hemodialysis
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Istiana, Dian, Zaenal Arifin, Heni Agustini Megantari Putri, Syamdarniati Syamdarniati, and Dewi Nur Sukma Purqoti. "HUBUNGAN MEKANISME KOPING DENGAN TINGKAT KECEMASAN PASIEN GAGAL GINJAL KRONIK DI UNIT HEMODIALISA RSUD PROVINSI NTB." Jurnal Ilmiah STIKES Yarsi Mataram 11, no. 2 (December 23, 2022): 67–77. http://dx.doi.org/10.57267/jisym.v11i2.112.
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The Indonesian Society of Nephrology survey there are 18 million people in Indonesia suffering from chronic kidney disease. Chronic kidney disease is a progressive disorder of renal function and requires treatment in the form of kidney transplantation, peritoneal dialysis, hemodialysis and long-term outpatient treatment. Patients undergoing hemodialysis experience various problems arising from kidney malfunction. Anxiety is a psychological impact that hemodialysis patients often complain about. Coping mechanism is one of the factors that affect the patient's anxiety. This study aims to determine the relationship of coping mechanism with anxiety level in chronic renal failure patients in Hemodialisa Unit of NTB Provincial Hospital. This type of research is quantitative research with correlational research design using cross sectional approach. The selection of samples was conducted by purposive sampling method with a sample count of 69 respondents. The research instruments used HARS questionnaire, and Jalowiec Coping Scale questionnaire. Analyze the data in this study using Chi-Square test analysis. The results showed that there was a link between coping mechanisms and anxiety levels in chronic renal failure patients in the Hemodialysis Unit of NTB Provincial Hospital with a significance value of 0.009 (p<0.05). With the results of this study, it is expected that the family can provide support to patients to use adaptive coping so as to lower the level of anxiety of patients.
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Touil, Driss, Abderrahmane Boualam, Ilias El Harchaoui, Ismail Louragli, Mahjoub Aouane, and Ahmed Omar Touhami Ahami. "QUALITY OF LIFE AND ITS GENERATING FACTORS IN HEMODIALYSIS PATIENTS HOSPITALIZED AT THE REGIONAL HOSPITAL IDRISSI KÉNITRA MOROCCO." Acta Neuropsychologica 20, no. 1 (February 23, 2022): 67–79. http://dx.doi.org/10.5604/01.3001.0015.8110.
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To assess the quality of life of patients with chronic end-stage renal failure under hemodialysis, and to determine its main generators in hemodialysis patients. This is a descriptive and analytical cross-sectional study carried out at the regional hospital of Kénitra (Morocco) in the level of the hemodialysis unit during a period of 3 months with 70 hemodialysis patients diagnosed and treated for chronic renal failure. Data were collected using a questionnaire comprising the socio-demographic, clinical, and nutritional characteristics of Hemodialysis patients and a KDQOL scale (Kidney Disease Quality Of Life) that assesses the quality of life. The scores of the KDQOL-36 were used to assess family, social support, and social support from caregivers. The average age was 51.66± 15.96 years with 57.1% of patients who are female. The components of the quality of life studied show an alteration in the quality of life with a decrease in the scores of the “component of physical health” dimensions with a score of 27.64 ± 29.13,“Component of mental health” with a score of 37.81 ± 22.99, “effects of kidney disease on daily life” with a score of 48.41 ± 21.22 and “burdens of kidney disease” with a score of 28.47 ± 21.50. While the dimension “Symptoms / problems of kidney disease” remains close to normal with a score of 64.61 ± 17.98. Our results showed that certain dimensions of the quality of life correlate with age, sex, family situation, level of education, the presence of a transplant plan, the presence of comorbidities and the duration of hemodialysis. Our study also found a correlation between family social support and quality of life in its “Burdens of Kidney Disease”, “Effects of Kidney Disease on Daily Living”, and the overall quality of life score. On the other hand, there is no significant relationship with support from caregivers. The quality of life of hemodialysis patients is deteriorating. It is influenced by several parameters including family and caregiver social support. The involvement of the family and the health care team in the psychological support process is paramount.
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Naaman, Ronak Muhammad, and Sana Thanoon Ahmed. "Quality of Life among Caregivers of Patients with Chronic Renal Failure Undergoing Hemodialysis in Duhok City." Journal of duhok university 25, no. 2 (November 9, 2022): 86–96. http://dx.doi.org/10.26682/sjuod.2022.25.2.8.
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BACKGROUND: Caregivers of hemodialysis (HD) patients play a critical role in their care which can influence their quality of life. As a result, the present study aimed to examine the quality of life among hemodialysis caregivers and their relationship with some characteristics of caregivers and patients. SUBJECT AND METHODS: This descriptive cross-sectional survey was directed to assess the quality of life among family caregivers of hemodialysis patients. consecutive sampling was done and included (139) caregivers who had inclusion criteria. The period of data collection was from the 2nd of November 2021 to the 10th of February 2022. The Short Form 36 questionnaire was used to collect data. a p-value of < 0.05 was statistically significant. RESULTS: Of 139 caregivers, the mean quality of life, physical and mental component scores were 59.49 ± 22.13, 63.2 ± 25.5, and 52.7 ±27.8 respectively. The scores of the physical functioning domain had the highest score (75.4 ± 24.74), while the Energy/Fatigue domain obtained the lowest score (46.19±25.86). There was a significant negative correlation between age and the quality of life (r=-0.3858, P<0.0001). Additionally, the quality of life was higher among younger, male, single, educated, and employed caregivers at a p-value (<0.0001, =0.0003, <0.0001, =0.0022, and =0.0091) respectively. CONCLUSION: Caregivers of hemodialysis patients had a satisfactory total quality of life score. Energy/Fatigue and mental health, on the other hand, were the most affected domains. These findings emphasize the necessity of addressing the mental health of caregivers, as well as providing them with financial and psychological support
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Kusyani, Asri, Diah Sari Sekar, Vendi Eko Kurniawan, and Hadi Sutomo. "IMPROVE THE QUALITY OF LIFE OF HEMODIALISA PATIENTS WITH DECREASE ANXIETY AND IMPROVE FAMILY SUPPORT." Well Being 3, no. 1 (August 2018): 1–7. http://dx.doi.org/10.51898/wb.v3i1.25.
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Chronic renal failure results in progressive and irreversible renal dysfunction, so that Hemodialysis patients experience symptoms of anxiety and decreased quality of life. quality of life is the perception of the individual in the ability of the limitations, symptoms and psychosocial nature of his life in the cultural context (physical, psycho, social, environment, spiritual). The quality of life of CKG patients with hemodysis therapy is still an interesting issue by health professionals. Low quality of life will improve hospitalization and mortality in hemodialysis therapy patients. The purpose of this study is to improve the quality of life of hemodialysis pasein by increasing family support and decreasing anxiety of Hemodialisa Patients In Hemodialisa Unit of RSUD Jombang. The design of this research is Correlation Analysis with Cross Sectional approach. The population of hemodialysis patient in hemodialysis room of RSUD Jombang was 160 patients, sampling technique used quota sampling and got 32 respondents. Data was collected using a family support questionnaire, ZSRAS scale and WHQOL-BREF questionnaire analysis using spearmen rank correlation test. The result of correlation analysis between family support and quality of life is obtained ρ value = 0,029, number 0,029 <α (0,05) which means there is relationship between family support and quality of life. And the result of correlation between anxiety with quality of life obtained ρ value = 0.013, number 0.0013 <α (0.05) which means there is a relationship between anxiety with quality of life. Based on this it can be concluded that family support and anxiety levels of patients in hemodialysis are important factors that must be considered to improve the quality of life of dihemodialisa patients. health personnel, especially nurse hemodialisa should provide health education by providing support, both management support, environment and stress so that the patient's anxiety can be reduced, there by improving the quality of life of hemodialysis patients despite physical limitations.
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Trbojevic, Jasna B., Vidosava B. Nesic, and Biljana B. Stojimirovic. "Quality of Life of Elderly Patients Undergoing Continuous Ambulatory Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 21, no. 3_suppl (December 2001): 300–303. http://dx.doi.org/10.1177/089686080102103s53.
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Objective The aim of the present study was to evaluate the impact of continuous ambulatory peritoneal dialysis (CAPD) on the lifestyle of elderly patients. Patients and Methods Aspects of health-related quality of life (QL) were studied in 48 patients (16 men, 32 women) in end-stage chronic renal failure (ESRF) undergoing CAPD at the Clinic of Nephrology, Clinical Centre of Serbia. The first group comprised 20 adult patients (8 men, 12 women; age range: 35 – 59 years). The second group consisted of 28 older adult patients (8 men, 20 women; age range: 65 – 75 years). Mean length of CAPD treatment was 5.2 years in the first group and 3.67 years in the second group. Fifteen QL variables were investigated: marital status, family relationships, working ability, sleep, tiredness, appetite, wound healing, hobby, sports, friendships, sexual activity, mood, travel, self management, and happiness. Results The results showed that, in the examined groups, marital status and relationships with family members weren't influenced at all by dialysis. In both groups, CAPD had a negative influence on ability to bear cold and to travel, but other life functions were not significantly affected. Elderly patients had a significantly worse appetite ( p = 0.03, Fisher test) and mood ( p = 0.045, Fisher test) than did younger adults. In other examined variables, no statistically significant differences were found between the groups. Conclusions Lack of large, statistically significant differences between the groups suggests that CAPD has an equal influence on quality of life in younger and older adult patients.
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WIJAYANTI, DYAH, Dinarwiyata Dinarwiyata, and Tumini Tumini. "Self Care Management Pasien Hemodialisa Ditinjau Dari Dukungan Keluarga Di Rsud Dr.Soetomo Surabaya." Jurnal Ilmu Kesehatan 6, no. 2 (June 4, 2018): 109. http://dx.doi.org/10.32831/jik.v6i2.162.
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Self care management in patients with chronic renal failure who undergoing hemodialysis is a positive effort of patients to find and participate in their health services to optimize health, prevent complications, control symptoms, develop medical resources, minimize disturbance in diseases that can interfere with life. Family support is very important in the care of hemodialysis patients. The purpose of this study is to analyze the relationship of family support with self-care management of hemodialysis patients. The research method used analytic description with cross sectional approach. The population involved in this study were patients in the hemodialysis room of RSUD Dr.Soetomo Surabaya, with a sample size of 52 respondents, using consecutive sampling. Independent variable in this research is family support and dependent variable is self care management. Data collection using a family support questionnaire and modified hemodialysis patient self care measurement scale. Data were analyzed using spearman rho, with significant level p less than 0,05. The results showed that family support affects the self-care management of hemodialysis patients (p = 0.01). Family support affects the self-care management of hemodialysis patients in the hemodialysis chamber of Dr.Soetomo Hospital Surabaya. The importance of family support is necessary in treating hemodialysis patients for self-care management including monitoring of diet, stress management, safe diet, exercise, good habits, shunt care, diet therapy and observation of care instructions.
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Shimoyama, Setsuko, Orie Hirakawa, Keiko Yahiro, Toshimi Mizumachi, Andrea Schreiner, and Tatsuyuki Kakuma. "Health-Related Quality of Life and Caregiver Burden among Peritoneal Dialysis Patients and Their Family Caregivers in Japan." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 23, no. 2_suppl (December 2003): 200–205. http://dx.doi.org/10.1177/089686080302302s42.
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Objective Recent studies have found that patients with chronic renal failure suffer from depression and other symptoms of decreased mental health. However, little is know about caregiver burden and mental health among patients’ families. In the present study, we examined the relationship in Japan between peritoneal dialysis (PD) patients and caregivers with regard to health-related quality of life (HRQOL) and caregiver burden. Method In March of 2002, we recruited 60 subjects—26 patients on continuous ambulatory peritoneal dialysis (CAPD), and 34 caregivers—from a PD patient support group in southern Japan. We used the Kidney Disease Quality of Life Short Form (KDQOL-SF) and the Medical Outcomes Study Short Form 36 (SF-36) to measure HRQOL. We used the Zarit Burden Interview (ZBI) to measure caregiver burden. Data was also collected on each patient's duration of illness, treatment modality, age, sex, and medical history. All data were collected by mail surveys. Results Mean age of the PD patients was 48.2; mean age of the caregivers was 46.6. Mean caregiver burden on the ZBI was 14.1, which is considerably lower than that reported among caregivers for patients with dementia or stroke. Caregivers and patients both rated their general health and vitality among the lowest of the eight dimensions on the KDQOL-SF. In addition, patients scored lower than a normative population in all dimensions and significantly lower than caregivers in the dimensions of role physical functioning, role emotional functioning, and social functioning. Compared to national normative data for their age group, caregivers scored substantially lower in general health, vitality, and mental health. Conclusions Patients on CAPD are at risk for social role dysfunction, and their caregivers are at risk for decreased mental health. Further research is needed to identify interventions that can improve the HRQOL of CAPD patients and their family caregivers.
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Fadilah, Nikmatul, Dyah Wijayanti, and Tumini Tumini. "PENINGKATAN KUALITAS HIDUP PASIEN HEMODIALISA DITINJAU DARI PERILAKU CARING PERAWAT DI RSUD dr. SOETOMO SURABAYA." Jurnal Kesehatan Manarang 2, no. 1 (December 31, 2017): 26. http://dx.doi.org/10.33490/jkm.v2i1.10.
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Patients with chronic renal failure who undergoing hemodialysis decreased vitality, physical and psychological function that caused of decreased quality of life. The effect of caring to patient are improved relations of mutual trust, increase physical healing andsafety, have more energy, lower maintenance costs and create more comfortable feeling. The purpose of this study was to analyze the relationship between caring behaviors with quality of life. This study was analytic cross sectional. The sample was 60 patients in Hemodialysis Unit RSU Dr.Soetomo Surabaya, that was taken by purposive sampling. Independent variable wascaring behaviors, and dependent variable wasquality of life. Data were collected using 25-Caring Dimension Inventory (CDI 25) questionnaire and modifications Kidney Dissease Quality of Life Short Form. Data were analysis using Spearman's Rho test with α 0.05. The results showed that a good caring behavior (48.3%) and excellent (51.7%). The quality of life was moderate (83.3%). Spearman's rho test showed that the caring behavior did not significantly influence the quality of life with p value 0.229. The achievement of good judgment by patients need to be maintained and enhanced so that it will create a positive image of nurses from the public. Quality of life who have reached the moderate level needs to be improved, with a joint effort between the patient, family, and health workers. Improved quality of life, especially physical and psychological dimensions so that the patient will achieve adaptive coping strategies, while supported by families and health workers, especially nurses as part of the environmental and social dimensions of the patient.
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Arnold, Louise M., Jill Stephenson, Richard Kelly, David Buchanan, Gareth Jones, and Peter Hillmen. "Home Infusion of Eculizumab: A Unique and Innovative Model of Drug Delivery to Reduce Treatment-Associated Burden and Enhance Quality of Life for Patients with PNH." Blood 112, no. 11 (November 16, 2008): 4671. http://dx.doi.org/10.1182/blood.v112.11.4671.4671.
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Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal stem cell disease, characterised by intravascular hemolysis, bone marrow failure and lifethreatening thromboses. The median survival is 10–15 years, with the average age of presentation being in the 30’s. Symptoms include hemoglobinuria, fatigue, anemia, venous and arterial thromboses, recurrent pain, renal impairment, erectile dysfunction and pulmonary hypertension. The care of a patient with PNH is complex and challenging, as many experience chronic symptoms with periods of acute exacerbations. Historically the management of PNH included bone marrow transplant, blood transfusion and administration of additional supportive therapies, all necessitating regular visits to the hospital. Eculizumab, a monoclonal antibody that binds to the C5 complement component inhibiting the activity of terminal complement and thus preventing the destruction of red blood cells has dramatically altered the management of hemolytic PNH. Clinical trials of eculizumab demonstrated the resolution of the majority of symptoms and complications of PNH and resulted in its approval in the UK in June 2007. Eculizumab is administered as a 30 minute intravenous infusion every 14 days, and under the terms of its current EU licence, must be administered by a healthcare professional. In view of the rarity of PNH there are relatively few specialist Centres for the disease resulting in, patients travelling long distances for review and treatment. In view of the dramatic improvement in symptoms on eculizumab many patients are able to return to a near normal lifestyle. In the UK, Leeds Teaching Hospitals with Healthcare at Home have developed a home infusion programme that ensures safe administration of eculizumab in the patient’s home at a time convenient to them, leading to enhanced treatment-associated convenience for patients and their families. Patients then only attend the PNH Centre every 3 months to ensure appropriate monitoring and patient education. A recent survey of patients reports a reduction in treatment-associated burden for PNH patients and their families when receiving infusions at home. 46 patients responded to the survey with just over half receiving eculizumab. Of the 21 patients at the time receiving home infusions 19 found this more convenient than the hospital. Home treatment allows flexibility and for some, the return to full-time employment, with the associated financial benefits and improvement in psychological well-being. Of the 21 patients on home care 7 stated there ability to work was transformed with a further 10 having great improvement. Whilst the purpose of the survey was not to address financial burden, the home infusion programme has anecdotally reduced the financial burden on the patient and their family by eliminating the need for time off work, allowing return to full-time employment, and eliminating the cost of travel to and from the hospital for treatments. No patients reporting negative impact, including effect on social life and family relationships, whilst 15 experienced improvement or complete transformation in both areas. The patients reported confidence in the homecare programme, knowing that a very close working relationship existed between the expert hospital and homecare teams. This innovative programme of medication delivery by a dedicated home nursing team allows patients who have previously struggled to cope with their illness to lead a near normal life with an associated enhancement in quality of life. Patients are able to carry on with activities of daily life, including work, recreational activities and holidays, whilst at the same time ensuring compliance with treatment and therefore allowing maximum therapeutic benefit.
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Syuhada, Syuhada, Esteria Marhayuni, and Reza Anggraeni. "Hubungan Nilai Hematokrit Dan Nilai Trombosit Pada Pasien Demam Berdarah Dengue Di RSUD Dr. H. Abdul Moeloek Provinsi Lampung." MAHESA : Malahayati Health Student Journal 2, no. 2 (April 13, 2022): 320–31. http://dx.doi.org/10.33024/mahesa.v2i2.4499.
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ABSTRACT Dengue hemorrhagic fever (DHF) is a disease transmitted through mosquito bites of the genus Aedes, especially Aedes aegypti. This disease is caused by the dengue virus which belongs to the Arthropod-Borne Virus, the genus Flavivirus, and the family Flaviviridae. One of the laboratory parameters for diagnosing DHF is an increase in hematocrit and thrombocytopenia. So that blood tests are very useful in the patient's condition and in determining the prognosis. To determine the relationship between hematocrit and platelet values in patients with dengue hemorrhagic fever at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2020. This type of research is an analytic observational method (retrospective). This research was conducted at the Medical Records section of the Abdul Moeloek Hospital in Bandar Lampung from March 2021 to completion. The number of samples was 67 people using the main Whitney statistical test. In this study, there were as many as 67 research samples who were studied, stating that most of the DHF patients had thrombocytopenia, there were 64 respondents (95.5%) and those who had normal platelets were 3 respondents (4.5%). And of the 67 studies, it was stated that most DHF patients had normal hematocrit values, there were 47 respondents (77.6%), 13 respondents (19.4%) had high hematocrit values and 7 respondents had low hematocrit (10.4). %). The results of the Mann Whitney test showed that the value of p = 0.000 because the value of p = 0.000 <0.05 so that it can be stated that Ha is accepted and Ho is declared rejected or there is a significant relationship between the hematocrit and platelet values in dengue hemorrhagic fever patients. This study concludes there is a significant relationship between the hematocrit and platelet values in dengue hemorrhagic fever patients with a p-value = 0.000. Keywords: Chronic renal failure, Creatinine, Hemoglobin ABSTRAK Demam Berdarah Dengue (DBD) adalah penyakit yang ditularkan melalui gigitan nyamuk dari genus Aedes, terutama Aedes Aegypti. Penyakit ini disebabkan oleh virus dengue yang tergolong Arthropod-Borne Virus, genus Flavivirus, dan family Flaviviridae. Salah satu parameter laboratorium untuk menegakan diagnosis DBD adalah peningkatan hematokrit dan trombositopenia. Sehingga pemeriksaan darah sangat bermanfaat dalam pemantauan kondisi penderita dan penentuan prognosis. Tujuan penelitian ini untuk mengetahui hubungan nilai hematokrit dan nilai trombosit pada penderita Demam Berdarah Dengue di RSUD Dr. H.Abdul Moeloek Provinsi Lampung tahun 2020. Jenis penelitian ini dengan metode observasional analitik. Penelitian ini dilakukan di bagian Rekam Medik Rumah Sakit Abdul Moeloek Provinsi Lampung pada bulan Maret 2021 hingga selesai. Jumlah sampel sebanyak 67 orang menggunakan uji statistic mann whitney. Didapatkan sampel penelitian sebanyak 67 yang diteliti, menyatakan bahwa sebagian besar pasien DBD mengalami trombositopenia terdapat 64 responden (95.5%) dan yang memiliki trombosit normal terdapat 3 responden (4.5%). Dan dari 67 yang diteliti, menyatakan bahwa sebagian besar pasien DBD memiliki nilai hematokrit normal terdapat 47 responden (77,6%), yang memiliki nilai hematokrit tinggi 13 responden (19,4%) dan yang memiliki hematokrit rendah terdapat 7 responden (10.4%). Hasil Uji Mann Whitney didapatkan nilai p=0.000, karena nilai p=0.000 <0.05 sehingga dapat dinyatakan Ha diterima dan Ho dinyatakan ditolak atau terdapat hubungan yang bermakna, antara nilai hematokrit dan nilai trombosit pada pasien demam berdarah dengue. Terdapat hubungan yang bermakna, antara nilai hematokrit dan nilai trombosit pada pasien demam berdarah dengue dengan p-value = 0.000 Kata Kunci : Demam Berdarah Dengue, Nilai Hematokrit, Nilai Trombosit
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Kurnik, B. R., L. S. Weisberg, and P. B. Kurnik. "Renal and systemic oxygen consumption in patients with normal and abnormal renal function." Journal of the American Society of Nephrology 2, no. 11 (May 1992): 1617–26. http://dx.doi.org/10.1681/asn.v2111617.
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Systemic and renal oxygen consumption and hemodynamics were studied in patients with normal renal function (NI; serum creatinine concentration (Screat), 1.0 +/- 0.04 mg/dL) and those with moderate chronic renal failure with diabetes mellitus Screat, 2.7 +/- 0.2 mg/dL) or without diabetes mellitus (Screat, 2.4 +/- 0.1 mg/dL). Patients with chronic renal failure were anemic and had normal systemic oxygen consumption (NI, 10,564 +/- 277; chronic renal failure, 9,669 +/- 362 mumol of O2/min) and elevated systemic oxygen extraction (NI, 22.9 +/- 1; chronic renal failure, 30.9 +/- 1.2%) (P less than 0.02). Cardiac output and index and arterial oxygen saturation were equivalent in normal patients and in patients with chronic renal failure. Patients with chronic renal failure had higher renal oxygen extraction (NI, 7.3 +/- 0.8; chronic renal failure, 13.9 +/- 1%), lower RBF (NI, 572 +/- 146; chronic renal failure, 197 +/- 20 mL/min/kidney), and lower renal oxygen consumption per kidney (NI, 391 +/- 101; chronic renal failure, 177 +/- 20 mumol of O2/min/kidney) than did normal patients (P less than 0.02). There was a linear relationship between hemoglobin and RBF (r = 0.47, P less than 0.02). Patients with chronic renal failure and diabetes had lower RBF (diabetes mellitus, 146 +/- 23; without diabetes, 242 +/- 28 mL/min/kidney) and renal oxygen consumption per kidney (diabetes mellitus, 131 +/- 21; without diabetes, 218 +/- 29 mumol of O2/min/kidney (P less than 0.03) but equivalent renal oxygen extraction when compared with patients without diabetes. Patients with chronic renal failure without diabetes mellitus had higher renal oxygen consumption when expressed per 100 mL of creatinine clearance (diabetes mellitus, 1,016 +/- 150; without diabetes mellitus, 1,453 +/- 175 mumol of O2/min/100 mL of creatinine clearance; P less than 0.03). There was a significant linear relationship (P less than 0.005, r = 0.38) between calculated creatinine clearance and renal oxygen consumption with a y intercept representing basal renal oxygen consumption (115 mumol of O2/min/kidney) and a slope of 2.3 mumol of O2/mL. Patients with moderate chronic renal failure have normal systemic oxygen consumption but reduced RBF and renal oxygen consumption. The latter parameters are even lower in patients with chronic renal failure and diabetes. Renal hypermetabolism is more likely to exist in nondiabetic than diabetic renal disease. Basic human renal physiology and pathophysiology are described by the relationships between renal oxygen consumption, blood flow, oxygen extraction, and creatinine clearance in patients with normal and abnormal renal function of varied cause.
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Matsuda, M. "Gemcitabine for patients with chronic renal failure on hemodialysis." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 15189. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15189.
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15189 Background: Numerous studies of gemcitabine (GEM) as an agent for advanced pancreatic carcinoma (APC) have been reported. Although significant and/or unexpected toxicities of GEM have been reported even at low doses in patients (pts) with impaired renal function, no dosing recommendations have been developed for chronic renal failure (CRF). Methods: In this report, we present five APC pts with CRF and discuss the use of GEM for pts on hemodialysis (HD). Results: CASE 1. A-74-year old man with CRF (not on HD) received GEM (800 mg) on days 1 and 8. Grade 3 hematological toxicity (neutropenia and thrombocytopenia) occurred on day 9, which recovered immediately after HD was performed. Ten courses of GEM (800 mg x q2w) with HD initiated 6 h after administration have since been administered without any side effects. CASE 2. A-48-year old man underwent Whipple’s operation and received GEM (1000 mg x3 q4w) as adjuvant chemotherapy. After 10 cycles, he developed hemolytic uremic syndrome (HUS), which recovered immediately after performance of HD. HD was initiated 24 h after GEM (1000 mg), and this sequence was repeated 53 times until recurrence occurred. CASE 3. A-78-year old woman with recurrent pancreatic carcinoma developed HUS after 29 cycles of GEM (800 mg x q2w). After remission of HUS by starting HD, GEM was commenced again (HD was initiated 24 h after GEM at 1000mg x q2w), and has been administered 18 times. Both CASE 4 (a 65-year- old woman) and CASE 5 (a 56-year-old man) are APC pts with a long history of HD. Although HD was initiated within 24 h after GEM (1000mg) administration, Grade 3 hematological toxicity (neutropenia and leukocytopenia) occurred in these pts and we had to give up GEM after several courses. Conclusions: GEM (800–1000 mg) can be administered safely to pts with CRF on HD, especially soon after commencing HD, as long as HD is initiated within 24 h after GEM administration. In pts with a long history of HD, however, GEM should be administered with caution. No significant financial relationships to disclose.
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Silva, Fabiana Larissa Barbosa da, Geórgia Alcântara Alencar Melo, Regilane Cordeiro dos Santos, Renan Alves Silva, Letícia Lima Aguiar, and Joselany Áfio Caetano. "Assessment of pain in chronic renal failure patients going through hemodialysis." Rev Rene 21 (June 18, 2020): e43685. http://dx.doi.org/10.15253/2175-6783.20202143685.
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Objective: to assess the pain and the differences of this assessment with social, economic and clinical variables in individuals with chronic kidney disease. Methods: cross-sectional study, with 90 patients with hemodialysis clinics. Three instruments were used clinical/sociodemographic, visual analogue pain scale and McGill pain questionnaire. Mann-Whitney and Kruskal-Wallis U tests were used. Results: the most frequent kind of pain was musculoskeletal (35.6%), which was classified as moderate by using the visual analogue pain scale. In McGill’s questionnaire, the most selected categories were sensory and affective, which characterize pain as acute and thin. Significant statistical differences in medians of pain were found with family income, source of income, use of analgesics/anti-inflammatories, use of acupuncture and impaired sleep. Conclusion: pain was a recurrent result in various regions of the body among patients with chronic renal failure.
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Nur Soemah, Eka, and Galih Adiwibowo. "Correlation Hemodialysis Intensity with Anxiety in Chronic Kidney Failure Patients." JSRET 1, no. 1 (August 29, 2022): 34–40. http://dx.doi.org/10.29082/jsret.v1i1.6.
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This study looked at the link between hemodialysis intensity and anxiety in individuals with chronic renal failure who were receiving hemodialysis. A correlation analysis is the method of study. The population for this study consisted of 80 respondents, and 35 samples were taken using consecutive sampling methods. The Chi-Square test was used for data analysis in this study using SPSS for Windows version 25.0. The results of the research and data analysis can be used to draw the conclusion that there is a correlation between the intensity of hemodialysis and anxiety levels in patients with chronic renal failure undergoing hemodialysis, as determined by the Chi-Square test calculation of sig value of 0.020 0.05. The research was conducted on 35 respondents. It was determined that among patients with chronic renal failure receiving hemodialysis, there was a link between the intensity of hemodialysis and the degree of anxiety. The patient starts to adapt well and the degree of anxiety starts to reduce following continued therapy, which is expected to help the family support and encourage the patient.
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Firman, Rizky, Sri Mugianti, Imam Sunarno, and Sri Winarni. "The Quality Life of Renal Failure Patient Undergo Hemodialysis." Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery) 3, no. 2 (August 1, 2016): 118–22. http://dx.doi.org/10.26699/jnk.v3i2.art.p118-122.
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Chronic renal failure (CRF) is a public health problem in the world and is now recognized ascommon diseases with risk of hemodialysis therapy. Hemodialysis can have an impact to the patientquality of life. The aim of the research was to describe the patient quality of life with renal failure underghemodialysis at Mardi Waluyo Blitar hospital. The research used a descriptive research design. Thepopulation was all patients with renal failure which registered in Hemodialysis of Mardi Waluyo Blitarhospital on October-December 2014 as many as 84 patients. The sample was 34 patients selected byaccidental sampling. The data collection was conducted on March 30th – April 4th, 2015. The datacollecting used questionnaires of The World Health Organization Quality of Life (QoL WHO) whichdescribed physical health, psychological, social relationships, and environment. In general the qualitylife of renal failure patient underrgo hemodialysis in bad category was 55.9% (19 patients). Thiscondition was due to a chronic disease and its complications potentially stressors including renalfailure patient. Stressors that arise caused by environmental conditions, psychological state, and physicalhealth. The study recommended that health services were expected to provide comfortability, improvemaintenance functions, improve interpersonal relationships, and counseling.
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Isdiarti, Rika, and Iwan Ardian. "Correlation of Family Support with Quality of Life of Patient Chronic Renal Failure Undergo Hemodialysis." Jurnal Ners 15, no. 1Sp (April 1, 2020): 569–73. http://dx.doi.org/10.20473/jn.v15i1sp.22127.
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Introduction: Family support in patients with chronic renal failure undergoing hemodialysis consists of instrumental support, informational support, emotional support, hope support and self-esteem support. This support is provided throughout the patient's life. The purpose of this research to identify correlation between family support with quality of life of patient chronic renal failure with undergo hemodialysis.Methods: This research was a correlational study. The population was all chronic renal failure patients at one of general hospital in Demak, Central Java, Indonesia, from October to November 2019 as many as 60 patients. This study used total sampling which mean all 60 respondents joined in the study. The instrument is a quality of life questionnaire according to WHOQOL. Data was analyzed with bivariate analysis by using Somer's test with level of significance <0.05.Results: The results showed most of the respondent have family support enough counted 37 respondent (61.7%). Most quality of life of respondent is enough counted 31 respondent (51.7%). Statistical tests performed using Somer’s test show the results of a p-value of 0,000 or significance value of 0,000 <0.05.Conclusion: There is a correlation between family support with quality of life of patients chronic renal failure with hemodialysis. This research can be used as motivation for HD patients and families in improving the quality of life of patients by providing support to improve the patient's life spirit.
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Hwang, Ji-Yun, Ju-Hyun Cho, Yoon Jung Lee, Sang Pil Jang, and Wha Young Kim. "Family history of chronic renal failure is associated with malnutrition in Korean hemodialysis patients." Nutrition Research and Practice 3, no. 3 (2009): 247. http://dx.doi.org/10.4162/nrp.2009.3.3.247.
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Hirata, Kenshiro, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Chuang, Yuji Uchida, et al. "The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients." Toxins 13, no. 11 (November 18, 2021): 811. http://dx.doi.org/10.3390/toxins13110811.
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The binding of drugs to plasma protein is frequently altered in certain types of renal diseases. We recently reported on the effects of oxidation and uremic toxins on the binding of aripiprazole (ARP) to human serum albumin. In our continuing investigations, we examined the binding of ARP to plasma pooled from patients with chronic renal dysfunction. We examined the issue of the molecular basis for which factors affect the changes in drug binding that accompany renal failure. The study was based on the statistical relationships between ARP albumin binding and biochemical parameters such as the concentrations of oxidized albumin and uremic toxins. The binding of ARP to plasma from chronic renal patients was significantly lower than healthy volunteers. A rational relationship between the ARP binding rate and the concentration of toxins, including indoxyl sulphate (IS) and p-cresyl sulphate (PCS), was found, particularly for IS. Moreover, multiple regression analyses that involved taking other parameters such as PCS or oxidized albumin ratio to IS into account supports the above hypothesis. In conclusion, the limited data reported in this present study indicates that monitoring IS in the blood is a very important determinant in the dosage plan for the administration of site II drugs such as ARP, if the efficacy of the drug in renal disease is to be considered.
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Mahyuvi, Tata, and Siti Nur Hasina. "Improving the Compliance of Fluid Diet of Patients with Chronic Kidney Failure with Family Support-Based Health Education." Journal for Quality in Public Health 5, no. 1 (November 23, 2021): 348–53. http://dx.doi.org/10.30994/jqph.v5i1.277.
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Background: Failure of kidney function can lead to complications of other health problems, one of which is the condition of excess fluid volume caused by non-compliance with fluid dietary restrictions so that it triggers hypervolemia and results in excessive circulation burden, edema, cardiovascular disorders, impaired cognitive function and can lead to cause death. It is expected that patients with chronic renal failure undergoing hemodialysis therapy can comply with the prescribed fluid diet restrictions. Therefore, in increasing compliance, strong support is needed regarding the importance of fluid diet restriction management.
Objective: The purpose of this study was to analyze the Effect of Family Support-Based Health Education on Fluid Diet Compliance in Chronic Kidney Failure Patients.
Methods: The design of this study was a quasi-experimental with a pre and post design approach. The population of all patients with chronic kidney failure at Islamic Hospital Of Surabaya A. Yani was 82 patients. The sample size is 48 respondents. The sampling technique used simple random sampling. Patients are given family support-based health education in an effort to increase health knowledge in improving the health status of patients with chronic kidney failure with a family support approach to improve adherence to the fluid intake diet. The analysis used the Wilcoxon Signed Ranks test with p value < 0.05.
Results: The results of this study indicate p = 0.000 which means that there is a significant effect of Fluid Diet Adherence before and after Family Support-Based Health Education.
Conclusion: Family Support-Based Health Education is effective in improving Fluid Diet Adherence in patients with chronic renal failure and is highly recommended for patients undergoing hemodialysis therapy.
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Winata, Leo Chandra Wisnu Pandu, Wachid Putranto, and Mohammad Fanani. "Association between Hemodialysis Adequacy, Family Support, and Quality of Life in Chronic Renal Failure Patients." Indonesian Journal of Medicine 02, no. 01 (2017): 63–72. http://dx.doi.org/10.26911/theijmed.2016.01.03.07.
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Ersoy Dursun, F., G. Yesil, G. Sasak, and H. Dursin. "Familial atypical hemolytic uremic syndrome with positive p.S1191L (c.3572C>T) mutation on the CFH gene: A single-center experience." Balkan Journal of Medical Genetics 24, no. 1 (June 1, 2021): 81–88. http://dx.doi.org/10.2478/bjmg-2021-0007.
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Abstract The atypical hemolytic uremic syndrome (aHUS) is characterized by thrombocytopenia, microangiopathic hemolytic anemia and acute kidney injury (AKI), which can exhibit a poor prognosis. Complement factor H (CFH) gene mutations play a key role in this disease, which may be sporadic or familial. We studied 13 people from the same family, investigated for gene mutations of the familial aHUS after a family member presented to our emergency clinic with the aHUS and reported a family history of chronic renal failure. The p.S1191L mutation on the CFH gene was heterozygous in six people from the patient’s family with the aHUS. One of these family members is our patient with acute kidney injury, and the other two are followed at the Nephrology Clinic, Medeniyat University, Goztepe Training and Research Hospital, Istanbul, Turkey, due to chronic renal failure. The other three family members showed no evidence of renal failure. The index case had a history of six sibling deaths; three died of chronic renal failure. Plasmapheresis and fresh frozen plasma treatment were administered to our patient. When the patient showed no response to this treatment, eculizumab (ECZ) therapy was started. The study demonstrated that thorough family history should be taken in patients with the aHUS. These patients may have the familial type of the disease, and they should be screened genetically. Eculizumab should be the first choice in the treatment with plasmapheresis. It should be kept in mind that the use of ECZ as prophylaxis in posttransplant therapy is extremely important for preventing rejection.
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Hardianti, Anggia Fajar, Ika Yuni Widyawati, and Herdina Mariyanti. "Family Behavior in Maintenance Status Hb Chronic Renal Failure Patients through Family Centered Care Approach of Diet Fe Management." Jurnal Ners 8, no. 1 (April 2, 2017): 118–25. http://dx.doi.org/10.20473/jn.v8i1.3887.
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Introduction: Erythropoietic agent as standard practice for anemia treatment, which has a function to increase the value of hemoglobin (Hb) to 12 g/dl in patients with chronic renal failure (CRF), who receiving dialysis treatment. The use of erythropoietin has to keep of the iron/Fe amount in the body. Family who have a duty of care should have knowledge, attitude, and behavior to maintain patient’s Hb by giving support to the patient to obey the Fe diet. The aimed of this study was to investigate the effect of family centered care approach in management Fe diet toward family’s behaviour in maintenance Hb level of CRF patients in hemodialysis ward, Gambiran Hospital, Kediri.Method: This study was used a pre experimental design. Total sample were 10 respondents, who met to inclusion criteria. The independent variables were knowledge, attitude, and psychomotor of family in maintenance of Hb level in CRF’s patients. The dependent variable was Fe diet management with family centered care approach. Data was collected by using a structured questionnaire and home visit observation.Result: Data was analyzed by using Wilcoxon Sign Rank Test with significance level α≤0.05. Results showed that Fe diet management with family centered care approach took effect to family’s knowledge (p=0.011), family’s attitude (p=0.005) and family’s psychomotor (p=0.005) in maintenance Hb level of CRF patients.Conclusion: Family’s knowledge, attitude, and psychomotor were effected by experiences during the care of a patient, not affordable to access information and patient’s own decision. The strengths and weaknesses in the family to got a better plan of care can be made by discuss and sharing among researcher, patient and his family. It can be concluded that Fe diet management with family centered care approach took effect to family’s behaviour. Further studies should involve larger respondents and better measurement tools to obtain more accurate results.
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Statsenko, M. E., S. V. Fabritskaya, and Y. A. Ryndina. "The role of obesity in renal damage in patients with chronic heart failure." Nephrology (Saint-Petersburg) 24, no. 5 (August 31, 2020): 29–36. http://dx.doi.org/10.36485/1561-6274-2020-24-5-29-36.
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THE AIM: to study the functional state ofthe kidneys in patientswith chronic heart failure (CHF)and obesity. PATIENTS AND METHODS. 116 patients with CHF l-lll functional class (FC) 45-65 years old are divided into three comparable groups depending on body mass index (BMI). A physical examination was performed, evaluated the renal function, the level of leptin and adiponectin, assessed the insulin resistance index, the combined risk of progression of chronic kidney disease (CKD), and the development of cardiovascular complications was analyzed. RESULTS. Among patients with CHF and obesity, a statistically significant decrease in glomerular filtration rate (GFR) was observed compared with patients of the 1st group (61.3 [46.2; 67.1] vs 73.2 [62.1; 86.3] ml/min / 1.73 m2), a clinically significant decrease in GFR <60 ml/min /1.73 m2 (CKD C3a-3b), high (A2) and very high (A3) albuminuria (AU) compared in patientswith normal and overweight. The leptin concentration significantly increased from the 1st to the 3rd group, while the adiponectin concentration decreased from the 1st to the 3rd group. Statistically significant correlations were established between the concentration of leptin and GFR (r = -0.52), AC (r = 0.36), between the concentration of adiponectin and GFR (r = 0.38), AC (r = -0.32). Significant associations were found among patientswith overweight and obesity between the severity of AU, GFR, and HOMA-IR, metabolic index. CONCLUSION. A significant deterioration in the functional parameters ofthe kidneys in patientswith CHF with increasing body weight, as well as an increase in the combined risk of CKD progression and the development of cardiovascular complications with comparable FC, was established. The revealed reliable relationships reflect the significant pathogenetic contribution of the hormonal activity of visceral adipose tissue and insulin resistance to the development and progression of renal dysfunction in patients with heart failure and obesity.
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May, Emiliana Tawuru, Abdul Wakhid, and Yunita Galih Yudanari. "PERBEDAAN PENGETAHUAN SEBELUM DAN SESUDAH PENDIDIKAN KESEHATAN TENTANG TERAPIDIET CAIRAN DAN HEMODIALISIS TERHADAP KELUARGA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS." Jurnal Ilmu Keperawatan Jiwa 2, no. 2 (August 16, 2019): 115. http://dx.doi.org/10.32584/jikj.v2i2.333.
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Pendidikan kesehatan pasien atau keluarga merupakan kegiatan dalam perencanaan pulang pasien yang ditujukan untuk meningkatkan pengetahuan keluarga dalam memberikan perawatan selanjutnya dirumah. Tujuan penelitian ini untuk mengetahui perbedaan pengetahuan sebelum dan sesudah pendidikan kesehatan tentang terapi diet cairan dan hemodialisis terhadap keluarga pasien gagal ginjal kronik yang menjalani hemodialisis. Desain penelitian ini pre-experimental designs dengan pendekatanOne-Group-Pretest-Posttest Design. Populasi penelitian ini yaitu pasien gagal ginjal kronik yang menjalani hemodialisis dengan sampel 15 orang diambil menggunakan metode purposive sampling. Alat pengambilan data menggunakan kuesioner. Analisis data menggunakan program komputer. Analisis bivariat menggunakan ujit-Test Dependent. Pengetahuan keluarga pasien gagal ginjal kronik yang menjalani hemodialisis sebelum diberikan pendidikan kesehatan tentang terapi diet cairan dan hemodialisis sebagian besar kategori kurang (53,4%), dan sesudah pendidikan kesehatan sebagian besar kategori baik (86,7%). Ada perbedaan yang bermakna pengetahuan tentang terapi diet cairan dan hemodialisis sebelum dan sesudah pendidikan kesehatan pada keluarga pasien gagal ginjal kronik yang menjalani hemodialisis, dengan p-value = 0,000< 0,05.Ada peningkatan pengetahuan sesudah pendidikan kesehatan tentang terapi diet cairan dan hemodialisis terhadap keluarga pasien gagal ginjal kronik yang menjalani hemodialisis. Keluarga pasien gagal ginjal kronik yang menjalani hemodialisis sebaiknya meningkatkan pengetahuan tentang terapi diet cairan dan hemodialisis dengan aktif menggali informasi dengan aktif berkonsultasi dengan tenaga kesehatan yang berkompeten. Kata kunci: Terapi diet cairan dan hemodialisis, pengetahuan keluarga,gagal ginjal kronik DIFFERENCES OF KNOWLEDGE BEFORE AND AFTER HEALTH EDUCATION ABOUT THERAPIDYET LIQUID AND HEMODIALYSIS OF FAMILY OF CHRONIC KIDNEY PATIENTS WHO HAVE DONE HEMODIALISIS ABSTRACTHealth education of patient or family is an activity in planning a patient's return aimed at increasing family knowledge in providing further care at home.Objective of this study was to determine the knowledge differences before and after health education about fluid diet therapy and haemodialysis on families with patients with chronic renal failure undergoing haemodialysis. The design of this study was pre-experimental designs by using the One-Group-Pretest-Posttest Design approach. The population of this study were chronic kidney failure patients who underwent haemodialysis with sample of 15 people taken by using a purposive sampling method. The data collection tool used a questionnaire. Data analysis used computer program. Bivariate analysis used the t-Test Dependent. The family knowledge of patients with chronic renal failure who underwent haemodialysis before being given health education about fluid diet therapy and haemodialysis is mostly in poor category (53.4%), and after health education is mostly in good category (86.7%). There is significant differences in knowledge about fluid diet therapy and haemodialysis before and after health education in families of patients with chronic renal failure undergoing haemodialysis, with p-value = 0.000 <0.05. There are increased knowledge after health education about dietary fluid therapy and haemodialysis on families of patients with chronic renal failure undergoing haemodialysis. Families of patients with chronic kidney failure who undergo haemodialysis should increase their knowledge of fluid diet therapy and haemodialysis by actively digging up information and consulting with competent health professionals. Keywords: Fluid diet therapy and haemodialysis, family knowledge, chronic kidney failure
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Rustendi, Teten, Murtiningsih Murtiningsih, and Iin Inayah. "Kualitas Hidup Pasien Gagal Ginjal Kronis yang Menjalani Hemodialisa." Mando Care Jurnal 1, no. 3 (December 28, 2022): 98–104. http://dx.doi.org/10.55110/mcj.v1i3.88.
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Chronic renal failure is a progressive and irreversible renal function disorder in which the body's ability fails to maintain metabolism and fluid and electrolyte balance, causing uremia (retention of urea and other nitrogenous wastes in the blood). In Indonesia, the increase in patients with this disease has reached 20%. The data and information center of the Indonesian Hospital Association (PDPERSI) states that the number of patients with chronic kidney failure is estimated at around 50 people per one million population. Hemodialysis is very important for patients with chronic kidney failure because hemodialysis is one of the measures that can prevent death. However, hemodialysis cannot cure or restore kidney disease because it is unable to compensate for the loss of metabolic activity of kidney or endocrine diseases carried out by the kidneys and the impact of kidney failure and therapy on the patient's quality of life. Objective to determine the quality of life of chronic kidney failure patients undergoing hemodialysis. Using a literature review study method from scientific journals with keyword guidance. Scientific journals that were selected were 6 journals, each journal representing one quality of life of chronic kidney failure patients undergoing hemodialysis. The quality of life of patients with chronic kidney failure are mostly in the good or high category with many factors affecting the quality of life of patients with chronic failure who are undergoing hemodialysis. Based on the analysis that has been carried out, it shows that the quality of life of patients with chronic failure at the good or high category level the biggest influencing factors are family support and self-efficacy.
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Insfrán, José Luis Gamarra, Renato Soares Sanches Dias, and Cristina José Fernandes Sanches. "Factors Influencing the Quality of Life in Patients with Chronic Kidney Failure Subject To Hemodialysis." International Journal of Innovative Research in Medical Science 6, no. 02 (February 24, 2021): 152–57. http://dx.doi.org/10.23958/ijirms/vol06-i02/1060.
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Introduction: The patient with terminal chronic renal insufficiency in treatment with Dialysis, usually undergoes psychological and social changes, in his lifestyle and also in his spiritual life, which not only affect him, but the whole family of the. For this reason, it is essential to study the quality of life of this type of patient, since it allows us to analyze to what extent a patient's life is affected by the different interventions they require and by the damage caused by the disease and treatment. Objective: To describe the factors that influence the quality of life of patients with chronic renal failure undergoing hemodialysis in nephrology services. Materials and methods: A descriptive, retrospective and cross-sectional study was undertaken. Results: The research allowed determining that in the group of patients under study predominates: the older adult age range, married, presence of family support network, with complete basic education, of urban origin, with more than two pathologies associated with patient and in treatment for a period greater than one year. According to the Areas of the SF-36 health questionnaire, the Functional State Area is perceived as from Fair to Poor (90%); the Welfare Area as Good (70%), the General Health Perception as Good to Fair (92%) and the Health Change over time as Good to Fair (55%). Conclusion: In general, it was concluded that the perception of quality of life is Good. The factors considered to have an influence on this perception are: education, presence of a support network, marital status, origin, associated chronic pathologies and time on hemodialysis.
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Peco-Antic, Amira, Martin Konrad, Gordana Milosevski-Lomic, and Nikola Dimitrijevic. "Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis: The first four patients in Serbia." Srpski arhiv za celokupno lekarstvo 138, no. 5-6 (2010): 351–55. http://dx.doi.org/10.2298/sarh1006351p.
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Introduction Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive disease characterized by excessive renal magnesium and calcium wasting, bilateral nehrocalcinosis and progressive renal failure. This is the first report of FHHNC of four patients in Serbia. Outline of Cases The first three patients were siblings from the same family. The index case, a 9-yearold girl, presented with severe growth retardation, polyuria and polydipsia, while her brothers, 11 and 7 years old, were disclosed during family member screening. The father had a urolithiasis when aged 18 years, while intermittent microhaematuria and bilateral microlithiasis persisted later on. The fourth patient, a 16-year-old boy with sporadic FHHNC was discovered to have increased proteinuria at routine examination of urine before registration for secondary school. He was well grown up, normotensive, but had moderate renal failure (CKD 3 stage), mild hypomagnesaemia and severe hypercalciuria and nephrocalcinosis. Beside typical clinical and biochemical data, the diagnosis of FHHNC was confirmed by mutation analysis of the CLDN16 gene; in all four affected individuals a homozygous CLDN16 mutation (Leu151Phe) was found. Treatment with magnesium supplementation resulted in the normalization of serum magnesium levels only in one patient (patient 4), but hypercalciuria persisted and renal failure progressed in all patients. Conclusion FHHNC is a rare cause of chronic renal failure. The first four patients with FHHNC in Serbia have been here described. The diagnosis of FHNNC based on the findings of nephrocalcinosis with hypomagnesiaemia and hypercalciuria, was confirmed by homozygous paracellin1-mutation exhibiting a Leu151Phe. .
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Trihono, Partini P., Ommy A. Soesilo, and Rulina Suradi. "Acute renal failure in children: outcome and prognostic factors." Paediatrica Indonesiana 43, no. 6 (October 10, 2016): 205. http://dx.doi.org/10.14238/pi43.6.2003.205-10.
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Background Acute renal failure (ARF) is an emergency conditionwith a high mortality rate despite the long-known dialysis and ad-vanced supportive care. Only few studies on prognostic factors ofARF in children are available in the literature, which are difficult tocompare to each other due to the different definitions of the ARFoutcome used.Objective To find out the clinical and laboratory characteristics ofchildren with acute renal failure and the prognostic factors affect-ing the outcome.Methods This observational prospective study was conducted onchildren with acute renal failure hospitalized in the Department ofChild Health, Cipto Mangunkusumo Hospital, between July andDecember 2001. Patients with acute on chronic renal failure wereexcluded. Clinical and laboratory data were taken at the time ofdiagnosis and the outcomes were noted after 2 weeks of observa-tion. We classified the outcome as cured, uncured, and dead. Ana-lytical study was done to find out the relationships among variousprognostic factors.Results Fifty-six children with ARF were recruited in this study.Male to female ratio was 1.3:1; the mean age was 4.4 year-old.The most frequent presenting symptom was dyspnea (34%), fol-lowed by oliguria (29%). The most frequent primary disease wasmalignancy (20%). Most of the patients had renal-type of ARF(73%). The outcomes were cure (71%), no cure (16%), and death(13%). Bivariate analysis and logistic regression revealed thatyounger age (OR=13.6; 95%CI 1.01;183.60) and the need for di-alysis (OR=10; 95%CI 1.53;65.97) had significant relationships withmortality or no cure.Conclusion We should be aware when finding ARF patientsless than 5 year-old and have the indications for dialysis, due tothe poor prognosis they might have
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Alkhaqani, Ahmed Lateef. "Risk Factors and Complications of Chronic Kidney Disease: Narrative Review." Al-Rafidain Journal of Medical Sciences ( ISSN: 2789-3219 ) 2 (June 20, 2022): 107–14. http://dx.doi.org/10.54133/ajms.v2i.68.
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Chronic kidney disease (CKD) is associated with several adverse clinical outcomes, such as cardiovascular events, kidney failure requiring renal replacement therapy, mortality, and poor quality of life for survivors in general. CKD is a slow and progressive loss of kidney function over several years and may ultimately lead to the development of kidney failure. CKD has become a serious public health issue. Although cardiovascular disease, family history of CKD, and certain ethnic and racial backgrounds are important predictors of CKD risk, they do not contribute significantly beyond the scope of diabetes, hypertension, and older age. The number of CKD patients will continue to rise, reflecting the growing elderly population and increasing numbers of patients with diabetes and hypertension. As the number of CKD patients increases, primary care practitioners will be confronted with the management of the complex medical problems unique to patients with chronic renal impairment. As well documented in the literature, the nephrologist rarely manages the medical needs of CKD patients until renal replacement therapy is required. Whereas the symptoms of CKD in diabetes are few, many risk factors and biomarkers can be used to identify individuals at high risk for developing this condition. This article highlights the effect of risk factors and complications associated with chronic kidney disease at its various stages.
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Suwanti, Suwanti, Yetty Yetty, and Faridah Aini. "HUBUNGAN ANTARA EFIKASI DIRI DAN DUKUNGAN SOSIAL KELUARGA DENGAN MEKANISME KOPING KLIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISA." Jurnal Keperawatan Jiwa 5, no. 1 (February 6, 2019): 29. http://dx.doi.org/10.26714/jkj.5.1.2017.29-39.
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Hemodialisis pada klien Gagal Ginjal Kronik menyebabkan perubahan dalam hidup yang dapat membuat stres dan membutuhkan koping adaptif dalam mengatasinya.Kemampuan koping terhadap masalah yang dihadapi dapat dipengaruhi efikasi diri dan dukungan sosial keluarga. Individu yang memiliki efikasi diri tinggi dan dukungan sosial keluarga yang baik cenderung melakukan mekanisme koping yang adaptif. Tujuan. Tujuan penelitian ini untuk mengetahui hubungan antara efikasi diridan dukungan sosial keluarga dengan mekanisme koping klien Gagal Ginjal Kronik yang menjalani hemodialisa di RSUD Ambarawa. Design penelitian korelasional pendekatan cross sectional. Populasinya penderita Gagal Ginjal Kronik yang menjalani Hemodialisa sejumlah 48 pasien. Pengambilan sampel dengan total sampling. Sampel sebanyak 34 orang. Pengumpulan data dilakukan dengan menggunakan kuesioner. Analisis data dengan program SPSS, uji statistik Fischer’s Exact Test. Terdapat hubungan yang signifikan antara efikasi diri dengan mekanisme koping dengan p value sebesar 0,039 (α = 0,05) dan terdapat hubungan yang signifikan antara dukungan sosial keluarga dengan mekanisme koping dengan p value sebesar 0,004 (α= 0,05). Terdapat hubungan yang signifikan antara efikasi diri dan dukungan sosial keluarga dengan mekanisme koping nilai signifikansi 0,039 dan 0,004 pada α 0,05. Kata Kunci: Efikasi diri, dukungan sosial keluarga, mekanisme koping THE CORRELATION BETWEEN SELF-EFFICACY AND FAMILIES SOCIAL SUPPORT WITH COPING MECHANISMS CLIENTS CHRONIC RENAL FAILURE UNDERGOING HEMODIALYSIS ABSTRACTHemodialysis in chronic renal failure client causes changes in life that can create stress and need coping to solve. Coping mechanism with the problems encountered could be affected by self-efficacy and family social support. Client with high self efficacy and good family social support use adaptif coping mechanism. Purpose. The purpose of this study is to determine the correlation between self-efficacy and families social support with coping mechanisms clients Chronic Renal Failure undergoing hemodialysis at Ambarawa general hospital. This research used correlational design with cross sectional approach. The population were patients with Chronic Renal Failure who did Hemodialysis at RSUD Ambarawa as much as 48 patients. The sampling technique used total sampling. The samples study were patients with Chronic Renal Failure who did Hemodialysis that reguire inclusion and exclusion criteria as many as 34 people. The data collection was done by using a questionnaire. Data analysis was performed with SPSS by using Fischer’s Exact. There was significant correlation between self efficacy with coping mechanism (p value < 0,005). And there was significant correlation between family social support with coping mechanism (p value < 0,005). There is a significant correlation between self-efficacy and social support of families with coping mechanisms with significant value of 0.039 and 0.004 at α = 0.05. Keywords: Self efficacy, family social support, coping mechanisms
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Descamps-Latscha, B., A. Herbelin, A. T. Nguyen, P. Roux-Lombard, J. Zingraff, A. Moynot, C. Verger, D. Dahmane, D. de Groote, and P. Jungers. "Balance between IL-1 beta, TNF-alpha, and their specific inhibitors in chronic renal failure and maintenance dialysis. Relationships with activation markers of T cells, B cells, and monocytes." Journal of Immunology 154, no. 2 (January 15, 1995): 882–92. http://dx.doi.org/10.4049/jimmunol.154.2.882.
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Abstract Patients with end-stage renal disease present an immunodeficiency that paradoxically coexists with activation of most immunocompetent cells, and the roles of chronic uremia and maintenance dialysis are poorly understood. We determined circulating levels of IL-1 beta and IL-1Ra, TNF-alpha and its soluble receptors (TNF-sR55 and TNF-sR75), and activation markers of T cells (soluble CD25), B cells (soluble CD23), and monocytes (neopterin) in a large cohort of undialyzed patients at various stages of chronic renal failure and in dialyzed patients on maintenance hemodialysis or chronic peritoneal dialysis. The progression of uremia was associated with a gradual increase in soluble CD25, CD23, and especially neopterin levels. Although IL-1 beta could not be detected, IL-1Ra levels were significantly increased from the earliest stage of renal failure. Plasma levels of TNF-alpha, TNF-sR55, and TNF-sR75 progressed with the severity of renal failure and correlated with soluble CD25, CD23, and neopterin levels, whereas IL-1Ra levels correlated exclusively with TNF-sR55 levels. Compared with undialyzed patients, levels of IL-1 beta were higher in patients on maintenance hemodialysis, whereas those of IL-1Ra were lower and decreased further at the end of dialysis sessions. In contrast, both TNF-sR55 and TNF-sR75 levels were significantly higher than in undialyzed patients and increased further at the end of dialysis sessions in the absence of an increase of TNF-alpha. Such an imbalance between cytokines and their inhibitors may play a pivotal role in the multifaceted process of immune dysfunction.
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Rusmauli Lumban Gaol and Tekken Pebruanto Nahampun. "GAMBARAN DUKUNGAN KELUARGA TERHADAP KEPATUHAN PASIEN GAGAL GINJAL KRONIK MENJALANI HEMODIALISIS DI RSUP HAJI ADAM MALIK MEDAN TAHUN 2021." Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) 17, no. 1 (April 30, 2022): 177–83. http://dx.doi.org/10.36911/pannmed.v17i1.1256.
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Chronic kidney failure is kidney damage that causes the kidneys to be unable to remove toxins and waste products from the blood, characterized by the presence of protein in the urine and a decrease in the glomerular filtration rate, lasting more than 3 months. Family support is an attitude of action and family acceptance of supportive family members who are always ready to provide help and assistance if needed, in this case the acceptance of family support will know that there are other people who pay attention, appreciate and love them. Obedience is obedience or disobedience to orders, rules and discipline. Changes in individual attitudes and behavior start from the stage of compliance, identification, then internalization. Hemodialysis is a life-saving procedure performed by nephrology nurses to patients with impaired kidney function. The purpose of the study was to determine the description of family support for patients undergoing hemodialysis at Haji Adam Malik General Hospital Medan in 2021. This study used a descriptive method. The population in this study were all patients with chronic renal failure undergoing hemodialysis. The sampling technique used was consecutive sampling as many as 74 respondents. The results of research conducted at Haji Adam Malik General Hospital Medan as follows: family support for chronic kidney failure patients undergoing hemodialysis at Haji Adam Malik General Hospital Medan are mostly good categories as many as 70 respondents (94.6%), chronic kidney failure patient compliance in undergoing hemodialysis at Haji Adam Malik General Hospital in Medan, most of the good categories were 48 respondents (48.9%). Family support for patients and patient compliance with hemodialysis are in the good category, strongly supported by education because the higher a person's education, the faster he understands about the condition of the disease he is experiencing.
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Priyanka Tanwar, Mamta Naagar, Garima Malik, Md Shamshir Alam, Tarun Singh, Omveer Singh, and Manish Kumar Maity. "Relationship between right heart failure and cardio-renal syndrome: A review." World Journal of Biology Pharmacy and Health Sciences 13, no. 1 (January 30, 2023): 122–37. http://dx.doi.org/10.30574/wjbphs.2023.13.1.0011.
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In clinical practice, heart failure (HF) and renal impairment are coexisting illness which is linked with one another. Heart and kidney have bidirectional inter-relationships, and it has been suggested that the kidney is the most significant organ involved in acute HF. The "cardio-renal syndrome" (CRS) is defined as acute or chronic malfunction of one organ causing acute or chronic dysfunction of the other [1, 2]. Furthermore, renal failure in HF can lead to decreased diuretic efficacy, diuretic resistance, congestion worsening, and further deterioration of renal function, creating a vicious cycle. In patients with acute HF, renal impairment is also a powerful independent predictor of short-term and long-term prognosis [3 - 9]. Renal hypoperfusion caused by inadequate cardiac output and over diuresis has long been thought to be the etiology of CRS. However, research has progressively shown a relationship between venous congestion and CRS, rather than inadequate cardiac output, correlating the failing right heart to CRS in recent decades. Indeed, both RHF and CRS have complicated and intertwined pathophysiologies that may affect several organs and systems in addition to isolated heart and kidney disease. This study focuses on the pathophysiology of RHF and cardio-centric phenotypes of CRS ("Type 1" and "Type 2"), as well as treatment options.
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Kozlovskaya, N. L., Y. V. Korotchaeva, K. A. Demyanova, M. M. Engibaryan, M. S. Mikulyak, A. V. Bespalova, and T. V. Bondarenko. "PREGNANCY MANAGEMENT IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 4." Nephrology (Saint-Petersburg) 23, no. 2 (February 21, 2019): 109–16. http://dx.doi.org/10.24884/1561-6274-2019-23-2-109-116.
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Pregnancy in patients with an advanced stage of chronic kidney disease (CKD) remains a rather rare situation to date. This observation demonstrates our own experience of successfully management of pregnancy in a patient with chronic kidney disease stage 4. A special feature of this observation is an unclear diagnosis that led to CKD. Based on a combination of advanced CKD in a young patient with no kidney history, no changes in urine tests, increased blood pressure, hyperuricemia, and small cysts of both kidneys, a diagnosis of autosomal dominant tubulo-interstitial kidney disease was suggested, despite the lack of family history of renal disease. Since the kidney disease was first identified during pregnancy, the main areas of care were the correction of complications (anemia, calcium-phosphorus disorders), caused by the advanced stage of CKD and the prevention of pre-eclampsia as one of the most frequent complications of pregnancy in this cohort of patients. In order to timely diagnose preeclampsia, the patient was regularly monitored for angiogenesis markers. Conducting pregnancy was carried out by an interdisciplinary team of specialists (nephrologists, obstetrician-gynecologists). Pregnancy ended with the birth of healthy baby. After childbirth renal failure progressed.
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Shindrikov, Roman Yurevich, Olga Yurevna Shchelkova, Elena Alekseevna Demchenko, and Nadezhda Evgenevna Kruglova. "SOCIO-PSYCHOLOGICAL AND BEHAVIORAL CHARACTERISTICS OF PATIENTS WITH CHRONIC HEART FAILURE AWAITING HEART TRANSPLANTATION." Психология. Психофизиология 12, no. 4 (January 15, 2020): 44–54. http://dx.doi.org/10.14529/jpps190405.
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Aim. The article presents the results of psychological investigations of patients in the terminal stage of chronic heart failure (n = 105, average age 51.9 ± 0.9 years, males – 86.7 %) undergoing medical treatment at the Almazov National Medical Research Centre (St. Petersburg). The investigations were carried out before the medical commission for inclusion of patients into the waiting list for heart transplantation (HTWL). Materials and methods. After 6 months of treatment in a cardiology hospital, the patients were divided into 2 groups – the patients included in and retained their positions in the HTWL (n = 55) and the patients not included in or excluded from the HTWL (n = 55). That was done in order to identify the prognostically significant psychosocial characteristics of patients. Clinical, psychological and psychometric methods were used such as a structured interview, expert questionnaire for doctors, the Alcohol Use Disorders Identification Test (AUDIT), the Short Form-36 (SF-36). Results. Comparative analysis reveals a wide range of psychological characteristics, among which the indicators of adherence for treatment and willingness to change lifestyle have the greatest importance. Emotional support and relationships outside the family, an adequate understanding of the disease, an optimistic assessment of the outcome of surgery treatment, etc., as well as the presence of one's own family and minor children are essential in the structure of the psychosocial potential of patients during preparation for HT. Conclusion. Using the obtained results will improve the methodology and procedure for a comprehensive clinical assessment of patients with chronic heart failure before inclusion into the waiting list for heart transplantation, which is extremely important for advanced surgical technologies.
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Obineche, Enyioma N., Hussain Saadi, Sheela Benedict, Javed Y. Pathan, Christopher M. Frampton, and M. Gary Nicholls. "Interrelationships between B-Type Natriuretic Peptides and Vitamin D in Patients on Maintenance Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 28, no. 6 (November 2008): 617–21. http://dx.doi.org/10.1177/089686080802800612.
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Objective Experimental evidence suggests that vitamin D deficiency impairs cardiac structure and function. Our objective was to observe relationships between circulating levels of the cardiac natriuretic peptides and vitamin D levels in patients on chronic peritoneal dialysis. Method Measurements were made of circulating levels of 25-hydroxyvitamin D [25(OH)D] and plasma B-type natriuretic peptide (BNP) levels in patients receiving chronic peritoneal dialysis. Results Both BNP and the 1–76 amino-terminal fragment of pro-BNP correlated inversely with 25(OH)D levels ( rs = –0.60, p = 0.007, and rs = –0.64, p = 0.003, respectively) in patients on peritoneal dialysis. Conclusions Vitamin D deficiency in chronic renal failure may impair cardiac function, as manifested by elevated levels of B-type cardiac natriuretic peptides.
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Mehrotra, Rajnish, Rajiv Saran, Harold L. Moore, Barbara F. Prowant, Ramesh Khanna, Zbylut J. Twardowski, and Karl D. Nolph. "Toward Targets for Initiation of Chronic Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 17, no. 5 (September 1997): 497–508. http://dx.doi.org/10.1177/089686089701700514.
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Objectives To better defaine the targets for initiation of chronic dialysis, we compared the relationship between the normalized protein equivalent of nitrogen appearance (nPNA, g/kg standard weight/day) and weekly urea clearance (Kt) normalized to total body water (V) in predialysis chronic renal failure (CRF) patients and in patients on continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD). We also studied the relationships of other nutritional parameters to weekly Kt/Vurea in CRF patients. Design This cross-sectional study was a prospective observational design meant to study each patient once. Setting The University Hospital and Clinics and Harry S. Truman VA Medical Center, Columbia, Missouri. Patients Forty-five consecutive predialysis CRF patients were enrolled and the results compared with patients on CAPD and HD. Results In CRF, the nPNA calculated from urea appearance correlated with the weekly Kt/Vurea (r = 0.57, p < 0.0001) and, using exponential best-fit, nPNA = 1.217 x (1 - e-0.769Kt/v). This exponential relationship was similar to that for CAPD and both were different from that in patients on HD. Likewise, nPNAs, calculated from Kjeldahl nitrogen output, and weekly Kt/Vurea were correlated (r = 0.37, p = 0.014) and, using exponential best-fit, nPNA = 1.102(1 - e-0.867Kt/v), similar to the relationship in patients on CAPD. Evidence is presented that these relationships are not explained only by mathematical coupling. There was a significant correlation between the weekly Kt/Vurea and 24-hour urinary creatinine excretion. Conclusions The findings suggest that in CRF, as in CAPD, a weekly Kt/Vurea less than 2.0 is likely to be associated with a nPNA less than 0.9 g/kg standard weight. In CRF patients, initiation of chronic dialysis should be considered if weekly renal Kt/Vurea falls below 2.0 and a nPNA greater than 0.8 is desired.
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Reza, Iredho Fani. "Implementasi Coping Religious dalam Mengatasi Gangguan Fisik-Psikis-Sosial-Spiritual pada Pasien Gagal Ginjal Kronik." Intizar 22, no. 2 (December 24, 2016): 243. http://dx.doi.org/10.19109/intizar.v22i2.940.
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Penelitian ini menemukan bahwa pasien gagal ginjal kronik rentan mengalami gangguan aspek fisik-psikologis-sosial-spiritual yang bersumber dari gangguan psikologis dan fisik. Untuk mengatasi setiap aspek gangguan yang dialami pasien gagal ginjal konik, coping religious dalam perspektif agama Islam menjadi cara mengatasi permasalahan psikologis yang dialami pasien gagal ginjal kronik yang di implementasi dengan dua bentuk. Pertama, hubungan terhadap Allah SWT (hablun Min Allah) berupa pelaksanaan serangkaian ibadah, seperti: salat, zikir, puasa, berdoa, membaca Al-Qur’an. Kedua, hubungan dengan sesama manusia (hablun min an-nas), yaitu silaturahmi. Penelitian ini merupakan jenis penelitian mixed methods dengan rancangan penelitian embedded design. Jumlah subjek yang menjadi sampel dengan teknik random sederhana dalam penelitian ini berjumlah 62 pasien gagal ginjal kronik. Hasil penelitian ini diharapkan dapat memberikan masukan kepada pasien gagal ginjal kronik, untuk mempertahankan intensitas pelaksanaan ibadah dan meningkatkan pemahaman dan penghayatan keagamaan, sehingga dapat mengatasi gangguan fisik-psikis-sosial-spiritual untuk menyikapi pelbagai permasalahan kehidupan yang dihadapi.This study found that patients with chronic renal failure prone impaired physical aspect-psycho-social-spiritual that comes from psychological and physical disorders. To cope with every aspect of interruptions suffered kidney failure patients conic, religious coping in the perspective of Islam becomes a way to overcome psychological problems experienced by patients with chronic renal failure in the implementation of the two forms. First, there is a relationship to Allah (hablun Min Allah) in the form of implementation of a series of worship, such as prayer, remembrance, fasting, praying, reading the Qur'an. Second, there are relationships with human beings (hablun min an-nas), mostly called “the gathering”. This study is a mixed research methods with embedded design. The number of subjects sampled by simple random technique in this research consists of 62 patients with chronic renal failure. The results of this study are expected to provide input to chronic renal failure patients, to maintain the intensity of worship and increase understanding and appreciation to religion, so that it can cope with the physical disruption of social-psychological-spiritual-to address various life problems that occur.
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HADY, Zahra Abbas. "SOCIAL VARIABLES AFFECTING FUTURE ANXIETY IN PATIENTS WITH RENAL FAILURE : ANTHROPOLOGY RESEARCH AT THE DIALYSIS SCREENING CENTER IN BAGHDAD." RIMAK International Journal of Humanities and Social Sciences 03, no. 05 (June 1, 2021): 231–43. http://dx.doi.org/10.47832/2717-8293.5-3.23.
Full textAbstract:
Anthropology is concerned with the study of diseases to which a person is exposed and their psychological and social effects on his immediate and future life. Chronic and dangerous diseases threatening human life have become a problem in various societies, both developed and backward. Perhaps the scientific progress in the medical and health fields that most peoples and societies have enjoyed has become a double-edged sword as it has become a path for the spread of chronic organic diseases and psychological diseases that pose a clear threat to human life. And among the most important of these chronic diseases, kidney failure disease, which is considered one of the serious diseases that accompanies a person for a long period of his life, which affects the patient's physical and psychological condition, since this disease has negative dimensions on the psychological structure of the human being, as it intersects with many organic diseases And the dangerous psychological, that patients with chronic renal failure associated with and restricted to treatment and dialysis, generates in the patients “organic” physiological problems and various psychological problems, as this disease affects the family bonding of the patients' families. Inferiority and lack of respect and self-esteem, and consequently psychological disorders such as anxiety, depression, impotence and loneliness have been proven. Studies show that patients with kidney failure suffer from anxiety to a degree that does not allow them to fulfill their future life requirements as required, and their hope in life diminishes.
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Carr, Susan J., Debbie Moore, Kulvinder Sikand, and Robert I. Norman. "Raised Affinity for Extracellular Sodium of the Sodium-Lithium Countertransporter is Associated with a Family History of Hypertension and Uraemia in Patients with Renal Disease." Clinical Science 92, no. 5 (May 1, 1997): 497–503. http://dx.doi.org/10.1042/cs0920497.
Full textAbstract:
1. Increased affinity for sodium (Km) at an external site of the sodium—lithium countertransporter and altered membrane microviscosity in the surface regions of the lipid bilayer identifies a group of essential hypertensive patients with a genetic predisposition to hypertension. The present study investigated the kinetic properties of the sodium—lithium countertransporter and membrane microviscosity in patients with hypertension, renal disease and impaired renal function. 2. Sixty patients with renal disease (28 chronic renal failure, 30 hypertensive, 23 family history of hypertension) were investigated. Standard erythrocyte sodium—lithium countertransport activity, sodium affinity constant (Km), maximum reaction velocity (Vmax) and membrane microviscosity were measured. 3. Patients with renal disease and a family history of hypertension had significantly lower Km (P < 0.05) values and raised membrane microviscosity measured by 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene anisotropy (P < 0.05) compared with patients without a family history of hypertension. 4. Uraemic subjects had low Km values compared with patients with renal disease and normal renal function (P < 0.05). However, there was no significant difference in membrane microviscosity between uraemic and non-uraemic subjects. 5. In patients with a family history of hypertension, sodium-lithium countertransport activity and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene anisotropy are important markers of cellular changes in essential hypertension, independent of renal disease. Uraemia, independently of hypertension, produces an alteration in the function of the sodium—lithium countertransporter which has previously been associated with a genetic predisposition to hypertension and cardiovascular disease.
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Saputri, Virna Widora, Rico Januar Sitorus, and H. M. Zulkarnain. "The Quality of Life Chronic Renal Failure (CRF) Patients in Hemodialysis Unit at District General Hospital Pringsewu Regency Lampung Province in 2018." E3S Web of Conferences 68 (2018): 01009. http://dx.doi.org/10.1051/e3sconf/20186801009.
Full textAbstract:
The purpose of this study was to determine the factors that affect the quality of life of CRF patients in Hemodialysis Unit at Pringsewu District General Hospital. This study was conducted from February to May 2018 with cross sectional study design. The sampling technique using total sampling technique. Measurement of quality of life using KDQOL-SFTM version 1.3. The results found that quality of life scores were quite low in some domains and subscales. The mean of total score was 55.70 ± 21.30 with mean of Physical Health Composite (PHC) = 38.85 ± 9.26 and mean of Mental Health Composite (MHC) = 36.13 ± 7.08. Regarding the targeted area of ESRD, the scale of renal disease burden and occupational status scale resulted in the lowest score. The sleep quality scale score was 56.18 ± 20.72. Only 61 patients responded to questions of sexual activity with a score of 55.53 ± 27.44 on the scale of sexual function. In the 36-item health survey, the mean total score was 45.90 ± 21.95. The lowest score represented the limitations of roles caused by physical and emotional health problems. The result of statistical test showed that the variables significantly related to the quality of life of CRF patients were age, income, duration of hemodialysis and family support. Thus, family support was the variable that had the greatest impact on determining the quality of life of CRF patients. The CRF patients who lacked family support were 4.6 times more likely to lead poorer life compared to CRF patients who received good family support after being controlled by age, income, duration of hemodialysis, gender, working status, and diabetes mellitus variables.