Journal articles: 'Chronic pruritus'

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Zhai, Savage, Qiu, Jin, Valdes-Rodriguez, and Mollanazar. "Chronic Pruritus Responding to Dupilumab—A Case Series." Medicines 6, no. 3 (June 29, 2019): 72. http://dx.doi.org/10.3390/medicines6030072.

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Background: Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in treating a number of conditions including atopic dermatitis (AD) and asthma. Its success in reducing pruritus in AD has generated interest regarding its potential application in other pruritic conditions, such as chronic pruritus of unknown origin, uremic pruritus, and pruigo nodularis. Methods: In this retrospective analysis, we present a series of 20 recalcitrant pruritus patients seen at a tertiary center treated with off-label dupilumab at standard AD dosing. Results: Dupilumab was successful at reducing itch in all treated patients, leading to complete resolution in 12/20 patients and an overall mean NRSi reduction of 7.55. Dupilumab was well tolerated with no significant adverse effects. Conclusions: Our case series suggests dupilumab may be a safe and efficacious therapeutic option in several pruritic conditions and demonstrates the need for further studies to better ascertain its place in the pruritus treatment armamentarium.

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Tareen, Attiya, Irfan Ullah, Ammara Safdar, Hadia Yaqub Khan, Uzma Rajar, and Habiba Yaqub Khan. "Generalized Pruritus: An Etiological Breakup of 700 patients presenting to dermatology opd of a local hospital." BMC Journal of Medical Sciences 3, no. 2 (January 13, 2023): 65–69. https://doi.org/10.70905/bmcj.03.02.049.

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Background: Pruritus is an itching sensation or a constant urge to itch over skin that may be localized in response to a local stimulus or generalized due to an underlying condition with or without presence of causative agent. It can be caused by dermatological or systemic conditions, iatrogenic or as a response to external substances such as parasites. Generalized pruritus may not be necessarily due to dermatological causes and systemic, neurologic, endocrinologic, and psychogenic conditions may have pruritus as a primary cutaneous manifestation. Skin conditions like Scabies, eczema and airborne dermatitis are commonly incriminated as reason for intense itching and so lab workup or clinical examination and history taking is often omitted, in our busy outdoors. Therefore, the purpose of this study is to rule out underlying common systemic diseases like hypothyroidism, diabetes mellitus and chronic renal and liver disease as cause of severe generalized pruritus. Objective: To identify the underlying cause of generalized pruritus in patients presenting to dermatology outdoor excluding pruritic dermatological diseases. Methodology: This is a cross-sectional observational study conducted on 700 patients from January 2018 to October 2021, in Fauji Foundation hospital Rawalpindi. Patients between the ages of 15 to 69 years visiting dermatology OPD of the department with complaints of generalized pruritus, who were recruited for the study after filling the consent form. Clinical investigations (Blood Cp, LFTS, RFTs, TFTs) and past medical history were taken to identify the underlying cause of pruritus was conducted and diagnoses were documented Only the patients who were having non dermatological causes were included in the study and the diagnoses were further categorized as idiopathic, systemic, endocrinological, neurogenic, psychogenic and drug induced. Results were compiled and analyzed using SPSS version 22. Results: The results of this study show that 700 participants with mean age of 47.39, out of which 110 were males and 590 were females had generalized pruritus. Out of them, 126 (19%) had pruritus due to chronic renal disease, 119(17%) had chronic liver disease, 63 (9%) had diabetes mellitus, 42 (6%) had paraneoplastic, 126(18%) senile pruritis, 35(5%) had cholinergic pruritus,21 (3%) iron deficiency anemia. 14(2%) had atopic dermatitis of elderly. Drug induced pruritus 56(8%). Conclusion: Pruritus without known pruritic dermatoses is a common presenting complaint in patients presenting to outdoors having one of the underlying systemic disease. Further work is needed to evaluate impact of pruritus on quality of life in these already diseased patients.

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Yosipovitch, Gil, and Jeffrey D. Bernhard. "Chronic Pruritus." New England Journal of Medicine 368, no. 17 (April 25, 2013): 1625–34. http://dx.doi.org/10.1056/nejmcp1208814.

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Ghassan, Ban, Jaffar N. Jaffar Alalsaidissa, Ali J. Hashim Al-Saedi, and Sabah N. Alawchi. "Relationship of Pruritus with Biochemical and Haematological Parameters in Haemodialysis Patients (A Single Center Study)." Journal of the Faculty of Medicine Baghdad 57, no. 4 (January 3, 2016): 306–11. http://dx.doi.org/10.32007/jfacmedbagdad.574396.

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Background: Pruritus often constitutes a major problem for patients with end stage renal disease. The pathophysiological mechanism of chronic kidney disease -associated pruritus is poorly defined.Objectives: To evaluate the prevalence of uremic pruritus in dialysis patients and their correlation with the laboratory and clinical parameters in some Iraqi patients with chronic renal disease.Patients & methods: This analytic, descriptive, cross-sectional study was performed on 103 patients on haemodialysis. Blood urea, creatinine, calcium, phosphorus, alkaline phosphatase and parathyroid hormone were determined. Complete blood count was also performed.Results: Of the 103 patients included in the study the, 79 patients (76.7%) had pruritus of whom, 27 (34.1%) had mild pruritus, 30 (38%) had moderate and 22 (27.9%) had severe pruritus. No significant association (p> 0.05) was found between pruritus and each of age and haemodialysis duration. There was no significant difference (p > 0.05) in the urea, creatinine, calcium, phosphorus, alkaline phosphatase, parathyroid hormone, hemoglobin, hematocrit, white blood cells, neutrophils, eoisinophils, basophils mean values among patients who had no pruritus, mild, moderate and severe pruritus. A significant positive correlation (p > 0.05) was found between severity of pruritus in pruritic patients and each of age, hemoglobin and hematocrit levels.Conclusion: Our study showed that age, hemoglobin and hematocrit levels had a significant positive correlation with the severity of pruritus in pruritic patients.

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Kupsa, Romana, Alexandra Gruber-Wackernagel, Angelika Hofer, Franz Quehenberger, Peter Wolf, and Franz J. Legat. "Narrowband-ultraviolet B vs Broadband-ultraviolet B in Treatment of Chronic Pruritus: A Randomized, Single-blinded, Non-inferiority Study." Acta Dermato-Venereologica 103 (June 26, 2023): adv9403. http://dx.doi.org/10.2340/actadv.v103.9403.

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Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g. in end-stage renal disease, broadband-ultraviolet B is recommended, but narrowband-ultraviolet B has also shown efficacy in reducing pruritus. This randomized, single blinded, non-inferiority study investigated the effects of narrowband-ultraviolet B compared with broadband-ultraviolet B. Patients with chronic pruritus were treated with either broadband- or narrowband-UVB 3 times a week for 6 weeks and clinical response was monitored. Pruritus, sleep disturbance, and the patients’ subjective overall response to treatment were evaluated by the patients on a visual analogue scale (0–10). Skin excoriations were evaluated by investigators on a 4-point scale (0–3). Both phototherapeutic modalities showed significant antipruritic activity (itch reduction 48% and 66.4%, respectively) by broadband-ultraviolet B and narrowband-ultraviolet B. Narrowband-ultraviolet B proved to be not inferior to broadband-ultraviolet B in treating pruritus in patients with chronic pruritus, assuming a 20% non-inferiority margin.

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Smith, Payton. "Treating Chronic Pruritus: Are We at the Threshold of a Breakthrough?" SKIN The Journal of Cutaneous Medicine 8, no. 4 (July 23, 2024): 1711–13. http://dx.doi.org/10.25251/skin.8.4.11.

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Chronic pruritis, characterized by persistent itchiness lasting more than six weeks, affects up to 15% of the population, significantly impairing quality of life. Despite its prevalence and impact, there is an absence of FDA-approved medications specifically for the treatment of chronic pruritus, highlighting a significant unmet need in dermatology. Advancements in dermatologic medications, however, including the development of biologics and Janus kinase (JAK) inhibitors, signal potential breakthroughs in pruritus management through a radically different mechanism of action that focuses on their effect on the nervous system. Currently, the most commonly utilized treatments for pruritis are sedating antihistamines, which have been largely ineffective for non-histamine-induced itch, underscoring the necessity for novel approaches. This editorial reviews key studies and clinical trials with a particular focus on cases of prurigo nodularis, where itch serves as the primary pathology rather than just a symptom. The effectiveness of dupilumab in phase III trials for treating prurigo nodularis, independent of its effects on dermatitis or atopic background, alongside the success of JAK inhibitors in managing chronic idiopathic pruritus, indicates a shift towards therapies that directly and specifically target itch nerve pathways instead of indirectly via immune system modulation or sedation. These developments suggest that significant progress may be on the horizon for treating chronic itch, providing hope for those suffering from pruritis, the number one cause of misery in dermatology.

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Yokoyama, Tomoaki. "Chronic Generalized Pruritus." New England Journal of Medicine 386, no. 6 (February 10, 2022): e12. http://dx.doi.org/10.1056/nejmicm2114503.

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Smucker, Joanne, Louis Portas, and Joslyn S. Kirby. "Overevaluating Chronic Pruritus." JAMA Internal Medicine 175, no. 6 (June 1, 2015): 895. http://dx.doi.org/10.1001/jamainternmed.2015.1041.

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Haq, Mazhar Ul, Rahmat Ali Khan, Najamud Din, Raza Muhammad Khan, and Sultan Zafar. "The Epidemiology of Chronic Kidney Disease-Related Pruritus and its Effect with Sleep Quality in Hemodialysis Patients in Pakistan A Cross-Sectional Study." Pakistan Journal of Medical and Health Sciences 16, no. 8 (August 31, 2022): 957–59. http://dx.doi.org/10.53350/pjmhs22168957.

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A glomerular filtration rate of less than 60 ml/min/1.73 m2 for more than three months is the medical definition of chronic kidney disease (CKD) caused by damaged kidneys. The incidence of chronic kidney disease, which can be fatal if left untreated, has been rising for the past 30 years. An unpleasant condition, Pruritus due to chronic renal disease causes itching and decreases the quality of sleep. This study aims to examine the factors associated with Pruritus in CKD patients on maintenance hemodialysis and their impact on sleep quality. Duration and Place: Since 01/01 2019 and ending in 30/06/2019 that year, I will be working as a Post graduate trainee Nephrology in the Nephrology Department at the Institute of Kidney Diseases in Peshawar. Methodology: The department of Nephrology Institute of kidney diseases provided 120 patients with the chronic renal illness. Patients with chronic kidney disease who experienced Pruritus and sleep disruption were included in the study, but those with rashes and Pruritus unrelated to CKD were not. All patients were questioned about their age, gender, typical sleeping habits, illness severity, poor sleep quality, and the location of any pruritus they experienced. Results: CKD-associated This is how pruritis was dispersed: Eighty-one Percent of patients were older than 90, while the remaining 24 percent were younger. Only 43% of those diagnosed with Pruritus reported it affecting their ability to sleep, while 57% reported no such disruptions; also, only 31% of those diagnosed were female, and 74% were male. About 56 percent of those suffering from Pruritus have it quite seriously, whereas 44 percent do not. 62% of Pruritus people experience it on their trunks, compared to 38% elsewhere. A high degree of Pruritus was associated with the female gender, affected body parts, and lack of sleep. Conclusion: Pruritus (sometimes called "uremic pruritus") is the most prevalent skin symptom among persons with ESRD. Despite the absence of evidence linking it to uremia, a significant connection exists in men over 45, causes sleep disruption, and predominates in the trunk. Keywords: CKD-Related Pruritus, Effect, Sleep Quality, Hemodialysis

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Ishii, N., T. Nishiyama, Y. Sugita, H. Nakajima, and I. Aoki. "Pruritic papular eruption of the acquired immunodeficiency syndrome." Acta Dermato-Venereologica 74, no. 3 (May 1, 1994): 219–20. http://dx.doi.org/10.2340/0001555574221223.

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We report a case of acquired immunodeficiency syndrome with pruritic papular eruption. The patient, a hemophiliac, presented with generalized pruritic, skin-colored papules and nodules. The chronic lesions were excoriated and hyper-pigmented. The eosinophil count was elevated, but IgE was normal. The lesions and pruritus responded only to ultraviolet B phototherapy. While the mechanism is not known, ultraviolet B phototherapy may provide relief of AIDS-related pruritus.

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Ain, Qurat Ul, Muhammad Sheheryar Asghar, Mohiuddin Saleem, Sana Majeed, Rubab Rameez, and Sidra Shaukat. "Incidence of Chronic Kidney Disease Related Pruritus and its Relation with Sleep Quality among Patients on Hemodialysis in Pakistan." Pakistan Journal of Medical and Health Sciences 16, no. 2 (February 26, 2022): 1165–67. http://dx.doi.org/10.53350/pjmhs221621165.

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Due to injured kidneys, CKD is defined as a glomerular filtration rate of less than 60ml/min/1.73m2 for more than 3 months. The lethal stage of chronic CKDs is the last stage of renal disease, and its frequency has increased over the previous 30 years. Pruritus caused by chronic renal disease is an unpleasant illness that causes itching and reduces sleep quality. The goal of this study is to look at the characteristics of pruritus in people with CKD and how they relate with sleep quality among patients on maintenance hemodialysis. Place and Duration: In the department of Medicine & Nephrology of Lahore General Hospital and Islamic International Medical College Trust Railway General Hospital, Rawalpindi for six-months duration from April 2021 to September 2021. Methods: 60 chronic renal disease patients were gathered from the nephrology department. Inclusion criteria included all patients with CKD who had pruritus and had sleep disturbance, while exclusion criteria included all patients who had rashes and pruritus that were not caused by CKD and were caused by other disorders. Age, gender, sleep pattern, disease severity, poor sleep quality, & pruritus location were all investigated by all patients. Results: CKD-associated Pruritus was distributed as follows: 75 percent of all patients were 45 years old or older, whereas 25 percent were 45 years old or younger. Pruritus interfered with sleep in 41.7% of patients, but not in 58.3%, and 30.1 percent of patients were girls and 73.9 percent were men. About 55% of people with pruritus are severely affected, whereas 45% are not. The trunk accounts for 60% of pruritic patients, whereas the rest of the body accounts for 40%. There was a strong link between the degree of pruritus and gender, the afflicted region, and sleep. Conclusion: Pruritus, often known as "uremic pruritus," is the most common skin complaint in people with ESRD. Due to the lack of a clear relationship with uremia, a substantial association occurs in males over the age of 45, disrupts sleep, and predominates in the trunk area. Keywords: Pruritus, Chronic renal disease, Characteristics, Association variables

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Ferreira, Bárbara R., and Laurent Misery. "Psychopathology Associated with Chronic Pruritus: A Systematic Review." Acta Dermato-Venereologica 103 (August 22, 2023): adv8488. http://dx.doi.org/10.2340/actadv.v103.8488.

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There are no previous studies of the psychopathology associated with different aetiologies of chronic pruritus. A systematic review was performed of cohort and case-control studies comparing healthy controls with patients with chronic pruritus related to primary dermatoses, systemic diseases, psychogenic pruritus, idiopathic pruritus, prurigo nodularis and/or lichen simplex chronicus. The review was registered in PROSPERO and performed according to the PRISMA statement, which allowed the inclusion of 26 studies. The quality of eligible studies was assessed using the modified Newcastle-Ottawa Scale. Most of the studies concern primary dermatoses and systemic diseases. Sleep disorders are a common comorbidity interrelated with pruritus, anxiety and depressive symptoms, in primary dermatoses. Sleep disorders are linked with pruritus and depressive symptoms in end-stage renal disease and hepatobiliary disease. Depressive and anxiety symptoms are associated with psychogenic pruritus. Psychogenic pruritus, lichen simplex chronicus and some primary dermatoses are linked with personality characteristics. Further studies are required to explore in depth the psychopathology linked with psychogenic pruritus and prurigo nodularis, as well as psychopathology linked with other primary dermatoses and systemic disorders associated with chronic pruritus, and to better differentiate psychogenic pruritus from psychopathological characteristics linked with other aetiologies of chronic pruritus, in order to improve the management of patients with chronic pruritus.

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Kandyil, Roshini, Nadia S. Satya, and Robert A. Swerlick. "Chronic Pruritus Associated with Helicobacter Pylori." Journal of Cutaneous Medicine and Surgery 6, no. 2 (March 2002): 103–8. http://dx.doi.org/10.1177/120347540200600202.

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Background: Helicobacter pylori is an established cause of gastritis and has been implicated in extradigestive diseases. Objective: To investigate the role of H. pylori in patients with unexplained refractory pruritus. Methods: Ten patients with severe pruritus unresponsive to conventional therapy were evaluated for active H. pylori infection by H. pylori serology followed by either esophagogastroduodenoscopy (EGD) or urea breath test. Of the 10 patients, 8 were found to have active infection. All 10 received anti- H. pylori antibiotic therapy and were reevaluated for relief of pruritus. Results: Of 8 patients with active H. pylori infection, 87.5% (7/8) had some type of pruritus relief after triple therapy. Of these, 62.5% (5/8) had complete relief and 25% (2/8) had temporary relief of pruritus. The remaining 12.5% (1/8) did not respond. Two control patients without active H. pylori infection had no relief of pruritus with therapy. Conclusions: We have identified a population of patients with refractory pruritus and active H. pylori infection whose pruritus resolved after eradication of H. pylori.

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Pereira, Manuel P., Sabine Steinke, Philipp Bruland, Hartmut F. Ständer, Martin Dugas, Matthias Augustin, and Sonja Ständer. "Management of chronic pruritus." Itch 2, no. 2 (September 2017): e6. http://dx.doi.org/10.1097/itx.0000000000000006.

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Damayanti. "Pruritus in elderly: Classification and management." World Journal of Advanced Research and Reviews 21, no. 1 (January 30, 2024): 254–59. http://dx.doi.org/10.30574/wjarr.2024.21.1.2637.

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Pruritus is majority complaint that is often encountered in dermatology. The diagnosis and management of pruritus still became important health problem in elderly. It is estimated that one fifth of the world’s population experience chronic pruritus which can affect their quality of life. The lifetime prevalence of chronic pruritus in the general population was 22%. In the elderly, two thirds of the population are reported to experience pruritus. Based on the onset of symptom, pruritus is divided into acute pruritus and chronic pruritus. While based on clinical complaints, pruritus is divided into pruritus originating from the skin, neuropathic pruritus, neurogenic pruritus, and psychogenic pruritus. Elderly skin is sensitive skin, which often gives complaints of itching. Pruritus, especially in elderly, requires treatment that must be adapted to the pathophysiology. Treatment of pruritus in the elderly can include topical therapy, systemic therapy and phototherapy. The management approach to pruritus consists of 4 important pillars, namely basic therapy, targeted therapy, symptomatic therapy, and therapy for accompanying diseases.

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Калганова, А. Н., and А. П. Музыченко. "Differential Diagnosis of Chronic Pruritus." Дерматовенерология Косметология 9, no. 3 (September 30, 2023): 291–95. http://dx.doi.org/10.34883/pi.2023.9.3.016.

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В статье представлены литературные данные по хроническому зуду, описаны основная классификация зуда, трудности диагностики и предложен диагностический алгоритм. Освещены критерии дифференциального диагноза хронического зуда. The article presents the literature review on chronic pruritus, describes the main classification of pruritus and diagnostic difficulties, proposes diagnostic algorithm. The criteria for the differential diagnosis of chronic pruritus are covered in detail.

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Bhalerao, Angeline, and Gurdeep S. Mannu. "Management of Pruritus in Chronic Liver Disease." Dermatology Research and Practice 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/295891.

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Background.There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease.Methodology.A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.”Results.The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary treatment options of the condition. These medical treatments range from bile salts, rifampicin, and opioid receptor antagonists to antihistamines.Conclusion.The burden of pruritus in liver disease patients persists and, although it is a common symptom, it can be difficult to manage. In recent years there has been greater study into the etiology and treatment of the condition. Nonetheless, pruritus remains poorly understood and many patients continue to suffer, reiterating the need for further research to improve our understanding of the etiology and treatment for the condition.

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Garcovich, Simone, Martina Maurelli, Paolo Gisondi, Ketty Peris, Gil Yosipovitch, and Giampiero Girolomoni. "Pruritus as a Distinctive Feature of Type 2 Inflammation." Vaccines 9, no. 3 (March 23, 2021): 303. http://dx.doi.org/10.3390/vaccines9030303.

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Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-31, IL-25, and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes, and type 2 T lymphocytes, and are master regulators of chronic itch. These cytokines might act as direct pruritogen on primary sensory neurons (pruriceptors) or alter the sensitivity to other itch mediators Type 2 inflammation- and immunity-dominated skin diseases, including atopic dermatitis, prurigo nodularis, bullous pemphigoid, scabies, parasitic diseases, urticaria, and Sézary syndrome are indeed conditions associated with most severe pruritus. In contrast, in other skin diseases, such as scleroderma, lupus erythematosus, hidradenitis suppurativa, and acne, type 2 inflammation is less represented, and pruritus is milder or variable. Th2 inflammation and immunity evolved to protect against parasites, and thus, the scratching response evoked by pruritus might have developed to alert about the presence and to remove parasites from the skin surface.

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Panahi, Yunes, Amirhossein Sahebkar, Shahram Parvin, and Alireza Saadat. "A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 49, no. 6 (October 4, 2012): 580–88. http://dx.doi.org/10.1258/acb.2012.012040.

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Background Chronic cutaneous complications such as pruritus are among the very frequent complaints of sulphur mustard (SM)-exposed patients. The present trial investigated the impact of curcumin on serum inflammatory biomarkers and their association with pruritus severity and quality of life (QoL). Methods This was a randomized, double-blind trial among 96 male Iranian veterans (age 37–59 y) who were suffering from chronic SM-induced pruritic skin lesions. Patients were randomly assigned to curcumin (1 g/d, n = 46) or placebo ( n = 50) for four weeks. Serum concentrations of interleukins 6 (IL-6) and 8 (IL-8) together with high-sensitivity C-reactive protein (hs-CRP) and calcitonin gene-related peptide (CGRP) were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score and QoL using the Dermatology Life Quality Index (DLQI). Results Serum IL-8 and hs-CRP were significantly reduced in both groups but the magnitude of reduction was greater in the curcumin group ( P < 0.001). Serum CGRP was only decreased in the curcumin group ( P < 0.001). No significant change was observed in serum IL-6. There were significant correlations between CGRP and IL-6 changes ( P = 0.011) and between DLQI and IL-8 changes ( P = 0.026) in the curcumin group. In the curcumin group, changes in serum IL-8 concentrations were found as the significant predictor of DLQI scores ( P = 0.026) but none of the independent variables could predict pruritus scores. Conclusions Curcumin supplementation effectively mitigates inflammation in patients suffering from chronic SM-induced cutaneous complications. This anti-inflammatory effect might account for the observed pruritus alleviation and QoL improvement by this phytochemical.

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Lu, Ping-Hsun, Chien-Cheng Lai, I.-Hsin Lin, Fu-Ming Tsai, and Po-Hsuan Lu. "Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials." Pharmaceuticals 15, no. 10 (October 9, 2022): 1239. http://dx.doi.org/10.3390/ph15101239.

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Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese herbal medicine significantly improved overall effectiveness (risk ratio 1.29, 95% CI 1.23 to 1.35), quality of life, renal function, reduced pruritus score, and inflammatory biomarkers compared to control groups with hemodialysis alone or with anti-pruritic treatments. Chinese herbal medicine treatment showed a time-dependent tendency in improving the visual analog scale of dialysis patients. Compared to control groups, no significantly higher risk of adverse events in patients taking Chinese herbal medicine (risk ratio 0.60, 95% CI 0.22 to 1.63). Chinese herbal medicine appears to be effective and safe in complementing the treatment of patients with uremic pruritus.

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Harvey, Naomi, Peter Craigon, Stephen Shaw, Sarah Blott, and Gary England. "Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus." Animals 9, no. 10 (October 16, 2019): 813. http://dx.doi.org/10.3390/ani9100813.

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Canine atopic dermatitis (cAD) is a common allergic skin condition in dogs that causes chronic pruritus. The overall quality of life in dogs with cAD is known to be reduced, and human patients with pruritic conditions report significant psychological burdens from pruritus-induced stress, and atopic dermatitis is associated with significant psychopathological morbidities. We tested the hypothesis that dogs with cAD would display more problem behaviours that could be indicative of stress than would healthy controls. Behavioural data were gathered directly from owners using a validated dog behaviour questionnaire for 343 dogs with a diagnosis of cAD and 552 healthy controls, and scores were also provided for their dog’s pruritus severity. Regression modelling, controlling for potential confounding variables (age, sex, breed, neuter status or other health problem(s)) showed for the first time that pruritus severity in dogs with cAD was associated with increased frequency of behaviours often considered problematic, such as mounting, chewing, hyperactivity, coprophagia, begging for and stealing food, attention-seeking, excitability, excessive grooming, and reduced trainability. Whilst causality cannot be ascertained from this study, the behaviours that were associated with pruritus severity are redirected, self/environment-directed displacement behaviours, which are often considered indicative of stress. Further investigation is warranted, and stress reduction could be helpful when treating dogs with cAD.

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Ryoo, Ji Hoon, Seon Hwa Lee, Dae-Lyong Ha, Kyung Duck Park, Jaehee Rho, Gyeong-Hun Park, Byung-Soo Kim, et al. "Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling." Acta Dermato-Venereologica 102 (November 24, 2022): adv00819. http://dx.doi.org/10.2340/actadv.v102.2527.

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Patients with chronic itch describe their pruritus in a wide variety of ways. However, these subjective descriptions are often not taken into consideration by physicians. This study aimed to validate patients’ descriptions of pruritus, and to investigate the relationship between various descriptions of pruritus and the patient burden of chronic pruritus by examining the mediating effects of sleep disturbance and sexual dysfunction on patient’s quality of life, as predicted by various descriptions of pruritus. Exploratory and confirmatory factor analyses were performed to identify the factor structure measured by 11 descriptions of pruritus. The study then analysed differences in the degree of sleep disturbance, sexual dysfunction, and quality of life deterioration factors using a structural equation modelling method. Using data from 419 patients with chronic pruritus, 11 descriptions of pruritus were classified into 2 groups: (i) sensory pruritus (i.e. stinging, stabbing, burning, painful, formication, throbbing, and cold) that are linked with descriptions of pruritus patterns; and (ii) affective pruritus (i.e. annoying, unbearable, worrisome, and warm) from patient reports of psychological or emotional distress. The study found that affective pruritus decreases patient’s quality of life either directly or indirectly through sleep disturbance. In conclusion, clues about a patients’ sleep disturbance or poor quality of life can be obtained through their descriptions of pruritus.

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Sari, Dede Wita Juwita Wulan. "OAT Lotion Reduces Itching Sensation Due to Pruritus in Hemodialysis Patients." Journal of Complementary Nursing 1, no. 3 (October 1, 2022): 84–90. http://dx.doi.org/10.53801/jcn.v1i3.47.

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Background: Hemodialysis is the most commonly used renal replacement therapy for chronic kidney disease. Symptoms caused if the patient has chronic kidney failure include uremia. Uremic pruritus is an uncomfortable condition for the patient, so it requires medication or treatment to help relieve it. Pruritus that occurs in hemodialysis patients causes itching and dryness of the skin. Objectives: The purpose of this study was to determine the effect of giving oat lotion on itching sensation in hemodialysis patients who experienced pruritus at the RS UMMI Bogor in 2020. Methods: This study used a quantitative method with a pre-experimental design and a one-group pre/post-test design. The sample selection used purposive sampling with a total of 20 respondents. The therapeutic action given is oat lotion which is applied to the part of the body that has uremic pruritus. Given 2 times a day (about 5 ml) for 7 days. The bivariate test used the Wilcoxon test. Results: the results showed that there was an effect of oat lotion on the itching sensation of hemodialysis patients who experienced pruritus, as evidenced by a decrease in the mean pre-test from 26.10 to 12.85 post-test with a p-value = 0.000. Conclusion: The itching sensation in pruritic patients undergoing hemodialysis will decrease by being given oat lotion.

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Adhikari, Laxman, Rajat Kayastha, and Karuna Bhatta. "Prevalence of uremic pruritus in chronic kidney patients undergoing maintenance hemodialysis at Kathmandu Medical College Teaching Hospital." Journal of Kathmandu Medical College 5, no. 4 (December 1, 2017): 124–27. http://dx.doi.org/10.3126/jkmc.v5i4.18610.

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Background: Uremic pruritus is a common and troublesome symptom of chronic kidney disease. It is one of the dominant dermatological manifestations of chronic kidney disease which affects the quality of life of patients.Objective: To assess the prevalence and severity of uremic pruritus in chronic kidney disease patients undergoing maintenance hemodialysis.Methodology: A prospective cross-sectional study was done over three months among chronic kidney patients undergoing maintenance hemodialysis to show the association of mineral bone disorders with uremic pruritus. Patients complaining of pruritus were taken as cases and then pruritus was quantified using a Visual Analogue Scale.Results: 144 patients participated in this study, out of which 41 (28.47%) were females. Mean age was 54.97±9.75 years and 68.06% patients were on dialysis. Uremic pruritus was seen in 80 patients (55.56%), amongst them 23 patients (28.75 %) had severe pruritus as measured by Visual Analogue Scale. Uremic pruritus was more frequent and more severe in patients having higher serum phosphorus levels (p =0.004).Conclusion: This study further substantiates the need of adequate control of phosphorus levels in hemodialysis patients to reduce complications like uremic pruritus.Journal of Kathmandu Medical College, Vol. 5, No. 4, Issue 18, Oct.-Dec., 2016, Page: 124-127

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Kaliuzhna, L. D. "CHRONIC PRURITUS IN CHILD’S SKIN DISEASES." Dermatology and Venerology, no. 3 (2020): 29–32. http://dx.doi.org/10.33743/2308-1066-2020-3-29-32.

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The article presents modern information on the clinical use and safety of the first-generation H1-antihistamine – dimetindene maleate. Pruritus (itch) mediators act both peripherally (histamine, proteases) and centrally (opioids) and has several mechanisms. Pruritus is the dominant symptom of skin diseases; almost all inflamamatory skin diseases can have associated pruritus. Doctors have focused on the almost one dermatosis with signs of itching – atopic dermatitis. At the same time, the range of diseases, both dermatological and systemic, accompanied by itching, is much wider.

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Görg, Max, Claudia Zeidler, Manuel P. Pereira, and Sonja Ständer. "Generalized chronic pruritus with fibromyalgia." JDDG: Journal der Deutschen Dermatologischen Gesellschaft 19, no. 6 (March 25, 2021): 909–11. http://dx.doi.org/10.1111/ddg.14498.

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Agarwal, Puneet, Vinita Garg, Priyanka Karagaiah, Jacek C. Szepietowski, Stephan Grabbe, and Mohamad Goldust. "Chronic Kidney Disease-Associated Pruritus." Toxins 13, no. 8 (July 28, 2021): 527. http://dx.doi.org/10.3390/toxins13080527.

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Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients with CKD-aP are mainly treated by nephrologists, primary care doctors, and dermatologists. Many treatments have been tried but nothing has been effective. The search of literature included peer-reviewed articles, including clinical trials and scientific reviews. Literature was identified through March 2021, and references of respective articles and only articles published in the English language were included.

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Vena, Gino A., and Nicoletta Cassano. "Toxic drug-induced chronic pruritus." Immunopharmacology and Immunotoxicology 34, no. 6 (May 18, 2012): 1075–76. http://dx.doi.org/10.3109/08923973.2012.690100.

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Pereira, Manuel P., and Sonja Ständer. "Measurement tools for chronic pruritus." Itch 4, no. 4 (October 2019): e29. http://dx.doi.org/10.1097/itx.0000000000000029.

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Bonchak, Jonathan G., and Peter A. Lio. "Nonpharmacologic interventions for chronic pruritus." Itch 5, no. 1 (January 2020): e31. http://dx.doi.org/10.1097/itx.0000000000000031.

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Yosipovitch, Gil. "Chronic pruritus: a paraneoplastic sign." Dermatologic Therapy 23, no. 6 (November 2010): 590–96. http://dx.doi.org/10.1111/j.1529-8019.2010.01366.x.

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JANCIN, BRUCE. "Aprepitant Relieves Refractory Chronic Pruritus." Skin & Allergy News 42, no. 1 (January 2011): 6. http://dx.doi.org/10.1016/s0037-6337(11)70008-0.

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Kandyil, Roshini, Nadia S. Satya, and Robert A. Swerlick. "Chronic pruritus associated withHelicobacter pylori." Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology 6, no. 2 (March 2002): 103–8. http://dx.doi.org/10.1007/s10227-001-0032-y.

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Weisshaar, E., J. Szepietowski, U. Darsow, L. Misery, J. Wallengren, T. Mettang, U. Gieler, et al. "European Guideline on Chronic Pruritus." Acta Dermato Venereologica 92, no. 5 (2012): 563–81. http://dx.doi.org/10.2340/00015555-1400.

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Grundmann, Sonja, and Sonja Ständer. "Chronic Pruritus: Clinics and Treatment." Annals of Dermatology 23, no. 1 (2011): 1. http://dx.doi.org/10.5021/ad.2011.23.1.1.

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Gupta, Aditya K. "Chronic Pruritus: An Uncommon Cause." Archives of Dermatology 124, no. 7 (July 1, 1988): 1105. http://dx.doi.org/10.1001/archderm.1988.01670070093030.

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Kumar, Ajay, Saujan Subedi, Abhisek Maskey, Mohammad Asim, Brijesh Sathian, and Deepika Neupane. "Uremic Pruritus and associated factors in Chronic Dialysis Patients: An Observational Study in Western Nepal." Birat Journal of Health Sciences 5, no. 3 (December 30, 2020): 1224–30. http://dx.doi.org/10.3126/bjhs.v5i3.33703.

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Introduction: Pruritus is one of the well-recognized major skin derangements in patients with advanced renal failure and are usually without visible skin lesions. Only few studies have addressed this issue in Nepalese population. Objective:.The present study aims to identify the prevalence and associated factors of uremic pruritus in chronic dialysis patients in western Nepal. Methodology:A prospective observational study was conducted to include all chronic dialysis patients with uremic pruritus at the Manipal Teaching Hospital, Pokhara, Nepal over a period of one year (June 2018 and May 2019). Results: During the study period, a total of 59 patients were included in the study with mean age of 55.8±15.8years,of which 37 (63%) patients developed uremic pruritus. Statistically significant relationship betweenpresence of pruritus and pruritus severity with frequency of itching grade and sleep disturbance score among elderly (p=0.001) were observed The serum urea can predict uremic pruritus among elderly patients with a good diagnostic value. The multivariate analysis showed male gender, hypertension, elevated serum albumin and random blood sugarwere independent predictors of pruritus in patients undergoing chronic dialysis. Conclusions: Our findings demonstrate that higher proportion ofpatients undergoing chronic dialysis werediagnosed with uremic pruritus (63%) and occurrence of pruritus had association with frequency of itching grade and sleep disturbance score .The serum levels of urea may predict the occurrence of pruritus among elderly patients.Furthermore, a large multicenter study is warranted with longer follow up which may provide robust information on the burden of pruritus and its associated factors to guide appropriate management among elderly.

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Nguyen, Christopher, and Monica Li. "Iron Deficiency Anemia Pruritus: A Review with Proposed Mechanisms of Action." SKIN The Journal of Cutaneous Medicine 8, no. 2 (March 18, 2024): 1365–73. http://dx.doi.org/10.25251/skin.8.2.2.

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Chronic generalized pruritus without a primary skin lesion presents a dilemma for clinicians. A minority can be attributed to systemic diseases. Iron deficiency anemia (IDA) presents one such poorly defined cause. We comprehensively review the literature to support IDA pruritus as a valid etiology in the patient with chronic, generalized pruritus. Several studies and case reports describe the association of pruritus and IDA, and more importantly, resolution of the pruritus upon iron supplementation, strongly suggesting IDA as the primary etiology. Thus, we recommend obtaining a CBC and iron studies in all cases of chronic generalized pruritus without a primary lesion. Based on currently available evidence, we also present novel mechanisms of actions in which iron deficiency may precipitate pruritus that have not been proposed in the literature. Iron deficiency may precipitate pruritus at the level of the skin through decreased skin thickness, elasticity, or barrier function, thereby promoting xerosis. Iron deficiency may also cause neurologic pruritus from damage, compression, or irritation of nerves. The levels of known chemical mediators of itch, such as serotonin, opioids, and neurotrophins, are also affected by iron homeostasis. IDA pruritus likely manifests from a complex interplay of multiple proposed pathways.

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Panahi, Yunes, Amirhossein Sahebkar, Mojtaba Amiri, Seyyed Masoud Davoudi, Fatemeh Beiraghdar, Seyyedeh Leila Hoseininejad, and Marjan Kolivand. "Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial." British Journal of Nutrition 108, no. 7 (November 18, 2011): 1272–79. http://dx.doi.org/10.1017/s0007114511006544.

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Skin is among the first and most heavily damaged organs upon sulphur mustard (SM) exposure. Pruritus is the most common chronic skin complication of SM, which adversely affects the quality of life (QoL). However, current therapies for the management of SM-induced pruritus are very limited and associated with side effects. The present trial investigated the efficacy of curcumin in the alleviation of SM-induced chronic pruritic symptoms. A total of ninety-six male Iranian veterans (age 37–59 years) were randomised to receive either curcumin (1 g/d, n 46) or placebo (n 50) for 4 weeks. Serum concentrations of substance P and activities of antioxidant enzymes were measured at baseline and at the end of the trial. Assessment of pruritus severity was performed using the pruritus score, visual analogue scale (VAS) and scoring atopic dermatitis (SCORAD) index. QoL was evaluated using the Dermatology Life Quality Index (DLQI) questionnaire. Serum concentrations of substance P (P < 0·001) as well as activities of superoxide dismutase (P = 0·02), glutathione peroxidase (P = 0·006) and catalase (P < 0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group. Curcumin supplementation was also associated with significant reductions in measures of pruritus severity including the pruritus score (P < 0·001), VAS score (P < 0·001), overall (P < 0·001) and objective SCORAD (P = 0·009), and DLQI's first question (P < 0·001). None of these measures was significantly changed in the placebo group. As for the QoL, although DLQI scores decreased in both groups (P < 0·001 and P = 0·003 in the curcumin and placebo groups, respectively), the magnitude of reduction was significantly greater in the curcumin group (P < 0·001). In conclusion, curcumin may be regarded as a natural, safe, widely available and inexpensive treatment for the management of SM-induced chronic pruritus.

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Perwiraningtyas, Pertiwi, and Ani Sutriningsih. "HUBUNGAN LAMA TERAPI HEMODIALISA DENGAN SKALA PRURITUS PASIEN GAGAL GINJAL KRONIS." Care : Jurnal Ilmiah Ilmu Kesehatan 9, no. 2 (July 2, 2021): 197–207. http://dx.doi.org/10.33366/jc.v9i2.2311.

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Patients with end-stage chronic renal failure required hemodialysis to survive for a long time. One of the complications of hemodialysis therapy is pruritus. Pruritus interfered with the patient's activities and sleep quality so that it has an impact on the quality of life. The purpose of this study was to determine the relationship between the length of hemodialysis therapy and pruritus in patients with chronic kidney failure. The research design is cross sectional. The population of all chronic kidney failure patients at Panti Waluya Hospital Malang during November 2020 who underwent hemodialysis was 56 people. Simple random sampling was used as the sampling technique, so that a sample of 45 people met the inclusion criteria. Analysis test with Mann Whitney, the result of the mean length of time patients undergoing hemodialysis is 2 years 5 months. The median score for patients with pruritus was 5 (moderate category – itching indicated frequent scratching). The results of the analysis test showed that there was a relationship between duration of hemodialysis and pruritus (p value = 0.033). Nurses in the hemodialysis room need to provide health education related to non-pharmacological management of pruritus as a result of hemodialysis therapy for patients with chronic renal failure. This is an effort to minimize the severity of pruritus that causes sleep disturbances so that it indirectly reduces the activity and quality of life of patients with chronic kidney failure. Keywords : Chronic renal failure, Hemodialysis, Pruritus

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Sembiring, Friska Br, Reisy Tane, and Lily Suryani. "PEMBERIAN AROMATERAPI PEPPERMINT KEPADA PASIEN HD DI RSU SEMBIRING DELI TUA." Jurnal Pengabdian Masyarakat Putri Hijau 1, no. 1 (January 15, 2021): 1–5. http://dx.doi.org/10.36656/jpmph.v1i1.508.

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Uremic pruritus is one of the complaints that often occurs in patients with chronic renal failure which is an uncomfortable sensation or itching and can cause disturbances during the day or night and can even occur throughout the day such as sleep disturbances, activity, depression and skin complications that can reduce quality of life for patients with chronic renal failure. Patients undergoing hemodialysis therapy will be faced with a variety of health status disorders, one of the most common complications is uremic pruritus (UP) with a multi-factor cause. The intensity and spatial distribution of pruritus were highly significant over time and patients varied to a greater extent and were influenced by the duration of renal impairment. This health education is to provide information about the benefits of peppermint in reducing uremic pruritus experienced by patients with chronic renal failure. This health education provides information about the benefits of peppermint in reducing uremic pruritus experienced by patients with chronic renal failure. This counseling was conducted at the Sembiring Deli Tua General Hospital. This counseling provides some information on the factors that cause and exacerbate the incidence of uremic pruritus in patients with chronic renal failure so that nurses can be more optimal in providing nursing care for patients with uremic pruritus, especially in patients with chronic renal failure.

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SAMI, M., T. TAHIR, P. MAL, AHK SHERWANI, MK LUHANO, and A. MANSOOR. "FREQUENCY OF CHRONIC KIDNEY DISEASE ASSOCIATED PRURITUS AND ITS ASSOCIATION WITH SLEEP QUALITY IN HEMODIALYSIS PATIENTS." Biological and Clinical Sciences Research Journal 2023, no. 1 (October 10, 2023): 443. http://dx.doi.org/10.54112/bcsrj.v2023i1.443.

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A cross-sectional study was conducted at the Department of Medicine, Khyber Teaching Hospital Peshawar, between November 2022 and April 2023. The study aimed to evaluate the frequency of pruritus associated with chronic kidney disease (CKD) and its correlation with sleep quality in hemodialysis patients. The study cohort comprised 55 individuals diagnosed with CKD, aged between 18 and 70, and of both genders. Chi-square and Independent Samples T-tests were used for statistical analysis, and a significance level of P < 0.05 was considered statistically significant. The study found that 39 (70.9%) patients reported chronic kidney disease-associated pruritus. Among the pruritus patients, 7.7% reported no effect on their sleep, 43.6% reported occasional sleep, and 48.7% reported severe effects on sleep. The study showed a significant association between increasing age and pruritus (P = 0.0001) but no significant association between pruritus and gender (P = 0.23). The mean age of the patients was 40.8±14.12 years. The study concluded that the prevalence of pruritus in hemodialysis patients with chronic kidney disease was very high. Also, pruritus in individuals with chronic renal disease significantly correlated with sleep quality and advancing age among hemodialysis patients.

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Chung, Bo Young, Ji Young Um, Jin Cheol Kim, Seok Young Kang, Chun Wook Park, and Hye One Kim. "Pathophysiology and Treatment of Pruritus in Elderly." International Journal of Molecular Sciences 22, no. 1 (December 26, 2020): 174. http://dx.doi.org/10.3390/ijms22010174.

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Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments.

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Silvestri, Silvestri, and Anggraeni Noviandini. "A Literature Review of Pruritus in Elderly." Asian Journal of Engineering, Social and Health 2, no. 10 (October 13, 2023): 1086–101. http://dx.doi.org/10.46799/ajesh.v2i10.142.

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Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments.

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Jovičić, Sanja, Jagoda Balaban, and Vesna Gajanin. "Association of systemic diseases with chronic pruritus." Scripta Medica 54, no. 2 (2023): 163–67. http://dx.doi.org/10.5937/scriptamed54-43882.

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Background/Aim: Pruritus is an unpleasant sensation that provokes the desire to scratch. It is one of the most common reasons why patients consult a dermatologist. Aim of this study was to determine the association of chronic pruritus with skin and systemic diseases, as well as the age and sex distribution in the studied population. Methods: The cross-sectional study included 120 patients of both sexes who, in the period from January 2017 to January 2021, received outpatient and inpatient treatment at the Skin and Venereal Diseases Clinic of the University Clinical Centre of the Republic of Srpska diagnosed with pruritus. Through the Clinical Information System insight was gained into the medical history and other documentation of the subjects from which data were taken on the age and sex of the subjects, onset, course and duration of pruritus, daily or seasonal variations in intensity, as well as the presence of associated skin and systemic diseases. Results: Out of a total of 120 subjects, a larger number (53.3 %) of subjects with chronic pruritus were male, and 46.7 % were female, the difference was statistically significant (p < 0.05). The analysis of the distribution of subjects according to their age revealed that the largest number of subjects (62.6 %) was over 65 years of age, while 38.4 % of subjects were under 65 years of age. The difference in the age structure was statistically significant (p < 0.05). In subjects older than 65 years pruritus was most frequently (47.3 %) associated with diabetes and in subjects under 65 years of age with skin diseases and conditions. The difference was statistically significant (p < 0.05). Conclusion: In people aged over 65 years, pruritus was most frequently associated with systemic diseases (diabetes mellitus) and in people aged under 65 years with dermatological diseases (Dermatitis atopica).

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Bata-Csörgő, Zsuzsanna. "Prurigo nodularis, prurigo chronica, new therapeutic options." Bőrgyógyászati és Venerológiai Szemle 97, no. 5 (October 29, 2021): 274–77. http://dx.doi.org/10.7188/bvsz.2021.97.5.6.

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Prurigo nodularis (PN) is a skin disease that develops on chronically itchy skin. There are various causes behind the chronic itch. Due to intensive research in recent years different mechanisms that can participate in the development of chronic pruritus have been discovered, opening up new therapeutic targets for treatment. Here we review the various mechanisms behind chronic pruritus and discuss the novel therapies for PN.

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Park, Soh-Yeon, and Won-Sik Shim. "Current Trends in Causes and Mechanisms of Pruritus Induced by Systemic Diseases." Yakhak Hoeji 66, no. 3 (June 30, 2022): 115–24. http://dx.doi.org/10.17480/psk.2022.66.3.115.

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Pruritus is a sensation that evokes a desire to scratch the skin. In particular, pruritus can be a burden for affected people when it becomes severe and chronic, as it deteriorates the quality of life. Dermatological diseases such as atopic dermatitis are mostly recognized as major pruritus-related disorders. Surprisingly, some non-dermatological systemic diseases can also evoke pruritus. In this review, we summarized the underlying causes and mechanisms of three nondermatological pruritus-related systemic diseases: including chronic kidney disease, cholestatic liver disease, and neoplasm. In addition, recent research observations and novel therapeutic strategies are discussed.

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Khanna, Raveena, Emily Boozalis, Micah Belzberg, John G. Zampella, and Shawn G. Kwatra. "Mirtazapine for the Treatment of Chronic Pruritus." Medicines 6, no. 3 (July 6, 2019): 73. http://dx.doi.org/10.3390/medicines6030073.

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Background: Chronic pruritus is a debilitating condition associated with a wide range of dermatologic, systemic and psychogenic etiologies. In patients with chronic pruritus that is refractory to conventional therapy, symptoms can significantly decrease quality of life by contributing to anxiety, sleep disturbances, and in many cases depression. Recent studies have demonstrated the effectiveness of mirtazapine in relieving chronic itch that is refractory to standard first-line therapies. Methods: We searched PubMed for English-language articles containing the words (“pruritus” or “itch”) AND “antidepressant” and then conducted a systematic review of the current literature to summarize the efficacy of mirtazapine in treating chronic itch. Results: All studies reported a reduction in itch intensity following the administration of mirtazapine. Conclusion: Collectively, these studies suggest the potential for mirtazapine to relieve chronic itch attributed to dermatological causes and malignancies. As, such mirtazapine may be an option for patients with chronic pruritus that is refractory to typical first-line treatments.

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Philipus, Vitta Margareth, Krisna Yetti, and Riri Maria. "Perawatan Topikal Berbasis Minyak pada Pasien Pruritus Uremik dengan Gagal Ginjal Kronis." Journal of Telenursing (JOTING) 6, no. 1 (April 2, 2024): 857–65. http://dx.doi.org/10.31539/joting.v6i1.9286.

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The aim of this study was to look at oil-based topical treatments that are effective in reducing and reducing the scale of uremic pruritus in patients with chronic kidney failure. The research method used in writing this systematic review was a literature search conducted through the Pubmed, Proquest, Science direct, Scopus databases with articles selected from 2010-2022. The results of this study showed a significant reduction in the scale of uremic pruritus in chronic kidney failure patients within 1-4 weeks of oil-based topical treatment. In conclusion, oil-based topical treatments are effective in reducing complaints of itching and pruritus in chronic kidney failure patients so that they can be used in nursing treatment. Key Word: Chronic Renal Failure; Oil Based Treatment ; Uremic Pruritus

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Retnaningsih, Dwi, Putri Puspitasari, and Dyah Restuning Prihati. "Pruritus and long-term hemodialysis among patients with chronic renal failure." International Journal of Public Health Science (IJPHS) 12, no. 3 (September 1, 2023): 998. http://dx.doi.org/10.11591/ijphs.v12i3.23067.

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Patients with hypertension and diabetes are at risk of developing chronic kidney failure. A common occurrence in patients with chronic kidney disease is pruritus. Pruritus can affect all parts of the body, which can have an emotional impact on the patient, affect the quality of sleep and mood of the patient, and cause discomfort. The study's goal was to determine whether there was a long-term link between hemodialysis and the onset of pruritus among patients with chronic renal failure who were receiving hemodialysis. Quantitative research with the cross-sectional method A total of 45 patients are in the RSI Sultan Agung Semarang Hemodialisa Unit, Central Java, Indonesia. The instrument in this study was the 5D pruritus scale. Data analysis was done using SPSS version 24. The Spearman rank test was conducted to test the relationship between two variables of the study, namely the duration of hemodialysis and the occurrence of pruritus. The study was conducted in April–June 2022, along with the ethical test. The results of the study obtained a p value of 0.004≤0.05, which means there is a relationship between long-term hemodialysis and the occurrence of pruritus in patients with chronic kidney failure. In conducting treatment, it is important to pay attention to basic needs and comfort, as well as implement pruritus management.

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Journal articles on the topic 'Chronic pruritus'

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