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1

Stevenson, Nicola Jane. "Lung mechanics in chronic obstructive pulmonary disease." Thesis, University of Liverpool, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432977.

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2

Roberts, Della Kim. "The family experience with chronic obstructive pulmonary disease." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24422.

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This study was designed to gain an understanding of the family experience when an adult member has chronic obstructive pulmonary disease (COPD). It is recognized that illness within the family affects the well-being of the family unit and the health of all members. To understand the impact of COPD upon the family, however, the literature provides only knowledge of the experience of the individual who has COPD and the spouse, not that of the family unit. Thus, the purpose of this study was to describe and explain the COPD experience from the perspective of the family unit. A qualitative method
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3

Sze, Marc Alexander. "The lung microbiome in chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36343.

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Until recently the normal human lung was thought to be sterile below the larynx, but recent reports from other laboratories indicate that a diverse microbiome exists and becomes less diverse in smokers. These reports led naturally to the hypothesis that pathogens emerging from the abnormal microbiome in smokers could drive the innate and adaptive immune response that has been associated with the pathology of peripheral lung abnormalities observed in Chronic Obstructive Pulmonary Disease (COPD). The purpose of the present study was to examine this hypothesis in human lung tissue. This began wit
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4

Dhillon, Satvir Singh. "Physical activity measurement strategies in advanced chronic lung disease." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50830.

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Background: Physical activity may reduce mortality risk in advanced chronic lung disease by optimizing functional capacity, which is a major prognostic indicator in lung transplantation candidates. There is uncertainty as to the optimal method to measure physical activity in this patient population. We assessed different commercially-available physical activity measurement techniques (flex heart rate monitoring (FHR); pedometry; tri-axial accelerometry; and multi-sensor technology) by investigating their agreement with indirect calorimetry (IC) in adult lung disease patients (chronic obstructi
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5

Toma, Tudor Paul. "Endoscopic lung volume reduction in chronic obstructive pulmonary disease." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428589.

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6

Sweet, D. G. "Studies on the pathogenesis of neonatal chronic lung disease." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395367.

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7

Kotecha, Sailesh. "The role of cytokines in chronic lung disease of prematurity." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244032.

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8

Soler, Artigas María. "Genetic epidemiology of lung function and chronic obstructive pulmonary disease." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/31980.

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Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. Lung function measures obtained through spirometry play a key role in the diagnosis of COPD. Both COPD and lung function are affected by genetic factors, and identifying genetic variants that have an effect on lung function or COPD risk has the potential to lead to improved treatment and prevention of COPD. This thesis is structured in five chapters, an introductory, a concluding chapter and three main chapters which present different approaches that aim to bring insights into the genetics of COPD and lung func
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9

Brandén, Eva. "Chronic infection with Chlamydia pneumoniae in COPD and lung cancer." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-344-2/.

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10

Steele, Bonnie Gail. "Dimensions of dyspnea in chronic obstructive pulmonary disease : a nociceptive model /." Thesis, Connect to this title online; UW restricted, 1991. http://hdl.handle.net/1773/7347.

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11

Ramis, Cabrer Daniel 1993. "From chronic obstructive pulmonary disease to lung cancer : an immunologic approach." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/667310.

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Se ha establecido que un subconjunto de pacientes con cáncer debuta con infiltrados inmunes que se organizan en agregados en el nicho tumoral y sus alrededores. Estas estructuras linfoides se desarrollan en respuesta a estímulos inflamatorios a través de un proceso estrechamente regulado. Además de su valor pronóstico, las TLSs pueden representar una nueva vía para las estrategias terapéuticas, pero actualmente se encuentra en etapas iniciales. En contraste con el papel en la activación inmune de las TLSs, en ciertos tumores, su efecto puede apuntar hacia la progresión tumoral como con
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12

Urs, Rhea Caroline. "Characterising Biomarkers of Chronic Lung Disease in Survivors of Preterm Birth." Thesis, Curtin University, 2021. http://hdl.handle.net/20.500.11937/88817.

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This research found preterm-born children displayed poor respiratory outcomes, with evidence of increased neutrophilic inflammation and oxidative stress, rather than the eosinophilic profile associated with “typical” childhood asthma. Additionally, metabolomic analysis showed preterm-born individuals have an altered metabolome from those born at term. Together this research provides insight into the contributors of chronic lung disease providing opportunities for early intervention and better lifelong respiratory outcomes in survivors of preterm birth.
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13

Lithopoulos, Marissa Athena. "Mesenchymal Stromal Cells to Treat Lung and Brain Injury in Neonatal Models of Chronic Lung Disease." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42124.

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14

Bhunthurat, Anurak. "The Vitamin B-6 Status of Patients with Chronic Obstructive Pulmonary Disease." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500541/.

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The problem of this study is to determine the vitamin B-6 status of patients who have chronic obstructive pulmonary disease (COPD). Erythrocyte aspartate transaminase assay was the method for measuring vitamin B-6 status. The vitamin B-6 status was examined in thirty subjects (ten COPD subjects and twenty control subjects). An unpaired t-test was used to compare the vitamin B-6 status of the COPD group versus the control group. Four determinants (percentage stimulation, ratio of basal to stimulated activity, basal activity, and stimulated activity) were used to determine vitamin B-6 status in
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15

Lehtonen, S. (Siri). "Localization and regulation of peroxiredoxins in human lung and lung diseases." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514277651.

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Abstract Reactive oxygen species (ROS) can cause severe damage to cells and organs but they are also important mediators of inflammatory responses and cellular signalling. Due to the significant role of ROS, the cells have evolved a broad antioxidative system to regulate the concentration of these species. Peroxiredoxins (Prxs) are enzymes that participate in the regulation of the cellular redox-homeostasis by detoxifying hydrogen peroxide. Prxs are not classified as conventional antioxidant enzymes and their physiological role, whether protective or regulatory, is still unclear. The aim of
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16

Merikallio, H. (Heta). "Claudins and epitheliomesenchymal transition in lung carcinomas and chronic obstructive pulmonary disease." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526202471.

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Abstract Lung cancers and chronic obstructive pulmonary disease (COPD) are the most common smoking-related lung diseases and both have high mortality rate. Tight junctions (TJ) are apical junctions between epithelial cells that regulate the permeability of epithelium and form the tight junction along with occludin. Dysfunction of the TJ and dysregulation of TJ proteins leads to a loss of cell-cell adhesion and a loss of cohesion as well as epitheliomesenchymal transition. These increase invasion of lung carcinomas and possibly predispose to the exacerbations in COPD. Therefore, the aim of this
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17

Vyas, Julian Ramesh. "Oxidants and antioxidants in the pathogenesis of chronic lung disease of prematurity." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29464.

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Reactive oxygen species and other radicals (e.g. peroxynitrite) are thought to play a role in the development of chronic lung disease of prematurity (CLD). I hypothesised that serial BAL may washout surfactant and cause persistent radiological changes. I also hypothesised that cellular antioxidants were depleted, and nitric oxide production was increased, in bronchoalveolar lavage fluid (BALF) from infants who developed CLD. Furthermore, my aim was to develop a technique to quantitate nitrite and nitrate in small (<50 microlitres) samples of BALF. 1 studied three groups of infants (those who d
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18

Joshi, Suchita. "Long term cardiorespiratory outcome in children with chronic lung disease of prematurity." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55504/.

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The findings of this thesis suggest that children with CLD continue to have airway abnormalities including reversible airway obstruction, air trapping and impaired gas transfer compare to term and preterm controls at 8-12 years of age. Although they had similar exercise capacity to preterm and term control groups, this was at the expense of using greater proportion of their ventilatory reserve. At school age, they do not have evidence of myocardial dysfunction or subclinical pulmonary arterial hypertension.
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19

Dai, Jie. "Clinical and genetic associations between lung cancer and chronic obstructive pulmonary disease." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19263/.

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Lung cancer and chronic obstructive pulmonary disease (COPD) are both leading causes of death in the world, and these two disease are closely linked in the clinical setting and at the genetic level. Previous studies have indicated that COPD confers a higher risk for development of lung cancer, and also affects prognosis once lung cancer has occurred. The present thesis further explored the influences of timing of COPD diagnosis, severity of airflow limitation, radiological emphysema, and genetic variants on lung cancer outcomes. Over 1,000 patients who were diagnosed with non-small cell lung c
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20

Jansson, Sven-Arne. "Health economic epidemiology of obstructive airway diseases : the obstructive lung disease in northern Sweden studies - thesis VII /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-805-3/.

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21

Curley, A. E. "The role of inflammation in the evolution of chronic lung disease in the neonate." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391115.

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22

Choate, Radmila. "ESTIMATING DISEASE SEVERITY, SYMPTOM BURDEN AND HEALTH-RELATED BEHAVIORS IN PATIENTS WITH CHRONIC PULMONARY DISEASES." UKnowledge, 2019. https://uknowledge.uky.edu/epb_etds/22.

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Chronic pulmonary diseases include a wide range of illnesses that differ in etiology, prevalence, symptomatology and available therapy. A common link among these illnesses is their impact on patients’ vital function of breathing, high symptom burden and significantly impaired quality of life. This dissertation research evaluates disease severity, symptom burden and health behaviors of patients with three different chronic pulmonary conditions. First, alpha-1 antitrypsin deficiency (AATD) is an inherited condition that typically is associated with an increased risk of early onset pulmonary emph
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23

Sze, Marc Alexander. "The bacterial lung tissue microbiome in the pathogenesis of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54530.

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Rationale: Several laboratories have shown that the decline in lung function in Chronic Obstructive Pulmonary Disease (COPD) is associated with increased formation of tertiary lymphoid follicles. This provides direct histological evidence in support of the hypothesis that the decline in lung function is associated with activation of an adaptive immune response. The antigens responsible for driving this immune activation remain poorly understood. The recent realization that the human lung contains a bacterial microbiome that changes in association with the presence of COPD suggests the hypothe
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24

Šileikienė, Virginija. "The effects of bronchial inflammation on lung function in chronic obstructive pulmonary disease." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130327_100737-84011.

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The aim of the study To investigate relationship between inflammation of the airways (bronchi) and pulmonary function. Objectives 1. To examine the levels of peripheral blood cytokines of patients suffering from COPD during exacerbation and remission, in order to detect non-invasive marker/markers of COPD that will enable us to differentiate infectious origin of exacerbation from non-infectious. 2. To investigate relationship between radiology changes of the lungs and respiratory function in patients suffering from chronic obstructive pulmonary disease. 3. To find out whether it is possible
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25

Powell, Wendy Elizabeth. "The role of IL-6 trans-signalling in chronic lung disease of prematurity." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/55501/.

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IL-6 trans-signalling was investigated in transformed airway epithelial cells (A549 and BEAS2B cells) and primary small airway epithelial cells (SAEC) in vitro. The cells expressed gp130 but not IL-6R. MCP-1 in response to IL-6 trans-signalling was variable and generally weak. Furthermore, IL-8 release was not downregulated by IL-6 trans-signalling. Instead, an increase in MCP-1 and IL-8 release was observed in response to a combined stimulation of IL-6 trans-signalling and IL-1[Special characters omitted]. This suggests that the pro-resolution paradigm of IL-6 trans-signalling may not be the
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26

Ahmed, Bushra. "Longitudinal investigation of the airway microbiota in children with chronic suppurative lung disease." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/62315.

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Recurrent airway infection and its complications are the leading cause of death in Cystic Fibrosis (CF) but remain poorly understood. Molecular microbiology demonstrates that the CF airways are more polymicrobial than previously thought. The role of the microbiota in disease prognosis is unclear. There have been few longitudinal studies of the airway microbiota in children, partly because sampling the lower airways is difficult as many children cannot expectorate. Part one of this thesis determined whether upper airway samples could act as surrogates for the lower airway microbiota in children
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27

Liu, Shiu Cheong Patrick. "Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease." Thesis, University of Dundee, 2019. https://discovery.dundee.ac.uk/en/studentTheses/ee8678d8-e7c7-498c-b501-ff5522f32ae5.

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Chronic lung diseases are often complicated with pulmonary hypertension (PH). This can lead to disability and poor prognosis. Oxidative stress has been implicated in the development of PH and right ventricular hypertrophy (RVH).A possible new way to treat lung disease related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a double-blind, randomised controlled clinical trial, 72 pati
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28

McColm, Janet R. "Inflammatory mediators in the lungs of preterm infants and their role in the development of chronic lung disease." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21402.

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The clinical pilot study enrolled 26 infants and measured IL-8, TNF-α and inflammatory cells in bronchoalveolar lavage samples. The results demonstrated that it may be possible to predict a group of babies at extremely high risk for developing chronic lung disease by early measurement of IL-8 in tracheal secretions. To further investigate the role of the genital mycoplasmas, <I>Ureaplasma urealyticum </I>and <I>Mycoplasma hominis,</I> a randomised study using an effective antibiotic, erythromycin, was carried out. A low grade untreated infection could persistently stimulate an <I>in vivo</I> i
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29

Li, Yinghua. "Ureaplasma urealyticum induced pulmonary inflammation in the development of chronic lung disease of prematurity /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-073-3/.

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30

Lindberg, Anne. "Chronic obstructive pulmonary disease (COPD) : prevalence, incidence, decline in lung function and risk factors." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-347.

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31

Jónsson, Baldvin. "Chronic lung disease of prematurity : a study of selected causative factors and preventive measures /." Stockholm, 1998. http://diss.kib.ki.se/1998/19981204jons/.

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32

Huang, Jing-Qi. "The immunoreactive expression of neuroendocrine cells or neuroendocrine bodies in human chronic lung disease /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61879.

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33

Bragman, Felix J. S. "Quantitative lung CT analysis for the study and diagnosis of Chronic Obstructive Pulmonary Disease." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045444/.

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The importance of medical imaging in the research of Chronic Obstructive Pulmonary Dis- ease (COPD) has risen over the last decades. COPD affects the pulmonary system through two competing mechanisms; emphysema and small airways disease. The relative contribu- tion of each component varies widely across patients whilst they can also evolve regionally in the lung. Patients can also be susceptible to exacerbations, which can dramatically ac- celerate lung function decline. Diagnosis of COPD is based on lung function tests, which measure airflow limitation. There is a growing consensus that this
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34

Harman, Katharine. "Exploring the relationship between loss of CFTR protein function and markers of disease severity in chronic suppurative lung disease." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/57500.

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Cystic fibrosis (CF) and Primary Ciliary Dyskinesia (PCD) are chronic suppurative lung diseases (CSLD). CF is characterised by inherited mutations affecting the cystic fibrosis transmembrane regulator (CFTR) protein, which is thought to be normal in PCD, however the role of CFTR in disease is incompletely understood. This thesis investigates the relationship between CFTR, inflammation and airway health, firstly in the context of the CF gene therapy Multidose trial followed by contrasting CF, PCD and control patients. The first study explored the relationship between lower airway potential diff
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35

Sharma, Pramod. "The Effect of Experimental Changes in Physiological and Psychological Factors on Perception of Exertional Dyspnea in Healthy Individuals." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365245.

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Dyspnea is a clinical term for the sensation of shortness of breath. It is a subjective experience perceived and reported by an affected person when referring to a feeling of the unpleasantness and discomfort related to breathing (Epstein, Manning, and Schwartzstein, 1995; Mukerji, 1990). Both healthy subjects and patients with heart and lung disease can experience this sensation, but a key difference is the level of activity at which this sensation becomes particularly troublesome (West et al., 2010). Typically, healthy subjects experience substantial dyspnea during heavy to severe e
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36

Stevens, Daniel. "Exercise testing and the physiological responses to exercise in young patients with chronic chest diseases." Thesis, University of Exeter, 2009. http://hdl.handle.net/10036/86037.

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The use of exercise is a valuable tool in the healthcare management of young patients with chronic chest diseases (CCD). Indeed, exercise testing yields important prognostic data which are a strong predictor of survival. Such information can indicate to the clinician to increase drug therapy treatment, and functional capacity of the patient can be monitored over time with repeated testing. Exercise training has been shown to improve both aerobic and anaerobic fitness and quality of life in patients with lung disease. The use of exercise testing and training in the healthcare of patients with l
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37

Subhedar, Nim. "The importance of pulmonary hypertension in the development of chronic lung disease in preterm infants." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264301.

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38

Leong-Smith, Phe. "Oxidative stress and metal homeostasis at the air-lung interface in Chronic Obstructive Pulmonary Disease." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/oxidative-stress-and-metal-homeostasis-at-the-airlung-interface-in-chronic-obstructive-pulmonary-disease(9c8de9c8-c5a1-4b40-9100-4a654a1e6274).html.

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Background: Chronic obstructive pulmonary disease (COPD) represents a spectrum of disorders encompassing chronic bronchitis and emphysema, associated with cough, excess mucus and exercise-related dyspnoea and characterized by a progressive reduction in airflow. Development of these symptoms is associated with chronic exposure to noxious particles or gas, most commonly from tobacco smoking, which triggers abnormal inflammation in the lung. Consistent with this increased inflammatory burden, oxidative stress has been demonstrated in COPD patients, largely through determination of antioxidant and
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39

Coxson, Harvey Owen. "Quantification of the tissue changes in the human lung with chronic lung disease using a combination of computed tomography and stereology." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0035/NQ27124.pdf.

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40

Hallin, Runa. "Nutritional Depletion in Chronic Obstructive Pulmonary Disease (COPD) : Effect on Morbidity, Mortality and Physical Capacity." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9512.

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The overall aim of this work was to examine the effects of depleted nutritional status on some aspects of Chronic Obstructive Pulmonary Disease (COPD). Morbidity. In paper І, we found that energy intake was lower than the calculated energy demand for all patients. A low body mass index (BMI) at inclusion and weight loss, during the one year follow-up period were independent risk factors for having a new exacerbation (p = 0.003 and 0.006, respectively). Mortality. Nineteen percent of the patients in paper ІІ, where underweight (BMI&lt;20). A significant positive correlation was found between BM
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41

Arne, Mats. "Chronic Obstructive Pulmonary Disease : Patients´ Perspectives, Impact of the Disease and Utilization of Spirometry." Doctoral thesis, Uppsala universitet, Lungmedicin och allergologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-113813.

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The overall aim of this thesis was to describe subjects with chronic obstructive pulmonary disease (COPD) from different perspectives. Focus was on patients at the time of diagnosis, impact of the disease in comparison to other chronic diseases, factors associated with good health and quality of life (QoL), and diagnostic spirometry in clinical practice. Methods: Qualitative method, grounded theory, was used to analyse patients´ perspectives at the time of diagnosis in a primary care setting (n=10). Public health surveys in the general population were used to compare chronic diseases (n=10,755
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42

Kammerl, Ilona [Verfasser], and Silke [Akademischer Betreuer] Meiners. "Proteasome and immunoproteasome function in cigarette smoke-mediated chronic lung disease / Ilona Kammerl. Betreuer: Silke Meiners." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/108831807X/34.

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43

Sridhar, Mangalam K. "An investigation into aspects of energy balance and nutritional status of patients with chronic lung disease." Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295327.

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44

Jackson, Victoria Emily. "Investigation into the role of rare genetic variation in lung function and chronic obstructive pulmonary disease." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/38645.

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Lung Function is a physiological measurement used for monitoring respiratory health and in the diagnosis of chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. Lung function and COPD are influenced by a combination of environmental and genetic factors. This thesis aims to investigate the genetic basis of these traits, with a particular focus on the effect of low frequency and rare genetic variants, so far largely overlooked in genome-wide association studies (GWAS). An analysis of exome array data and COPD identifies novel associations between CO
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45

Young, Jeanne. "Providing ethical care: cardiopulmonary resuscitation (CPR) for chronic obstructive pulmonary disease (COPD) exacerbations in patients with end stage lung disease (ESLD)." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92266.

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Cardiopulmonary resuscitation should generally not be offered to patients who suffer from a chronic obstructive pulmonary disease (COPD) exacerbation in the setting of end-stage lung disease (ESLD). Requests for CPR in this context may sometimes be uninformed, misguided, and the result of an unresolved grieving process by familial surrogates. While understandable, these requests rarely represent a truly autonomous patient perspective that is grounded in a competent, informed, and enlightened deliberation.<br>Alternatively, life-support technology and resuscitation is used appropriately when it
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46

Roos-Engstrand, Ester. "T cells in chronic obstructive pulmonary disease." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33677.

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47

Binder, William, Scott Clark, Edina Hall, Ferena Salek, and Jon Glover. "Effect of Adherence to the GOLD Guidelines on Chronic Obstructive Pulmonary Disease Related Readmissions in a Community Hospital." The University of Arizona, 2016. http://hdl.handle.net/10150/613978.

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Class of 2016 Abstract<br>Objectives: To assess the relationship between adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for the management of chronic obstructive pulmonary disease (COPD) exacerbations and the corresponding 30-day, all-cause readmissions rate in a community hospital. Methods: A retrospective chart review was conducted on patients admitted with the primary diagnosis of a COPD exacerbation. Medications administration records relevant to the GOLD guidelines were examined as separate independent variables in relation to a readmission with
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48

Finney-Hayward, Tricia Kate. "Monocyte-derived macrophages as a lung macrophage model in chronic obstructive pulmonary disease : characterisation and functional output." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/8330.

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49

Ling, Sean Hilton. "The relationship of particulate matter retention in the lung to the severity of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/23319.

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Particulate matter (PM) deposited into the lung is removed predominantly by ciliary action of epithelial cells in the airways and by macrophages that phagocytose these particles in the peripheral air space. We hypothesize that the particle load or burden in the lungs’ of patients with Chronic Obstructive Pulmonary Disease (COPD) are responsible for perpetuating the chronic inflammatory response in the lung of subjects with COPD (even after smoking cessation). Samples were selected to cover the whole range of severity of COPD. Quantitative histological methods were used to quantify and characte
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50

Green, Clara Emily. "Understanding shared pathogenesis between chronic obstructive pulmonary disease (COPD) and lung cancer by means of cell specific genomics." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8230/.

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Introduction: COPD (Chronic Obstructive Pulmonary Disease) and lung cancer are related conditions associated with inflammation. Relatively little focus has been given to the endothelium, through which inflammatory cells transmigrate to reach the lung. We sought to determine if coding and non-coding alterations in pulmonary endothelium exist in COPD and lung cancer. Methods: Patients with and without COPD undergoing thoracic surgery were recruited. Pulmonary Endothelial Cells were isolated from lung and tumour and extracted RNA (ribonucleic acid) used for miRNA (micro-RNA) and mRNA (messenger R
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