Dissertations / Theses on the topic 'Chronic diseases'
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Ye, Ping. "Autoimmunity in chronic periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4256.
Full textYe, Ping. "Autoimmunity in chronic periodontitis." University of Sydney, 2003. http://hdl.handle.net/2123/4256.
Full textProfound perturbation of epithelial structure is a characteristic feature of the immunopatholoical response to bacterial antigens considered to be central in the pathogenesis of the destructive lesion of periodontitis. The pathological basis for the disturbance of epithelial structure is not understood. It was demonstrated that the structural integrity and functional differentiation of the lining epithelium is compromised in relation to inflammatory changes associated with destructive periodontitis. In the pathological lining epithelium of the periodontal pocket there was a marked reduction of epithelial cadherin important in intercellular adhesion, of involucrin, a marker of terminal differentiation, and of the gap junction connexions that form intercellular communication channels. These changes were associated with alterations of filamentous actin expression, collectively indicating profound perturbation of epithelial structure. The data reported support the concept that the ability of the pathological lining epithelium to function as an effective barrier against the ingress of microbial products into the tissues is severely compromised (Ye et al., 2000). In addition, a recent study (Ye et al., 2003) by Western analysis of serum IgG from all 22 patients with chronic periodontitis tested indicated recognition of multiple epithelial components in individual patterns. In contrast, subjects with a healthy periodontium displayed only trace recognition of epithelial antigens. Levels of epithelial-reactive antibodies were significantly correlated with attachment loss as an indication of disease activity. To investigate a possible relationship between the bacterial flora adjacent to the diseased sites and the presence of epithelial-reactive antibodies, subgingival plague samples were taken from deep periodontal pockets and cultured anaerobically. Gram positive bacteria containing antigens potentially cross-reactive with epithelial cells were reproducibly isolated by probing membrane colony lifts with affinity-isolated (epitheial-specific) antibodies. The bacteria were identified as streptococci (S. mitis, S. constellatus and two S. intermedius strains) and Actinomyces (A. georgiae, and A. sp. oral clone) by 16S rDNA sequence homology. Recognition by affinity-isolated antibodies of antigens from the captured organisms was confirmed by Western analysis. Conversely, absorption of affinity-isolated antibodies with bacterial species specifically reduced subsequent recognition of epithelial antigens. To identify the auto-antigens, a human keratinocyte cDNA expression library in Lambda phage was probed using a pooled sera. Groups of responders were detected for CD24 (a recently described adhesion molecule also known as P-selectin ligand), antioxidant protein 2 (a newly recognised member of the thiol-dependment anti-oxidant proteins), lavtate dehydrogenase A, the transcription factor NFAT5, and for three genes encoding novel proteins. Six identified bacteria, especially S intermedius were demonstrated to absorb antibodies reaching with identified auto-antigens in patterns varying between individuals. This evidence indicated that during the course of periodontits, subjects develop increased levels of antibodies to common oral bacteria amongst which are included tissue cross-reactive antigens. Periodontitis could therefore present a risk for the subsequent initiation or exacerbation of a broad spectrum of disease processes including autoimmune, inflammatory, proliferative and degenerative disorders.
Ye, Ping. "Autoimmunity In Chronic Periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4872.
Full textPalma, Durán Susana Alejandra. "Protein glycation & chronic diseases." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8640/.
Full textCexus, Olivier. "Immunological mechanisms controlling chronic inflammatory diseases." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/67634/.
Full textAmoo, A., and Igor Antonovuch Plesh. "Anthroposophic art therapy in chronic diseases." Thesis, МАТЕРІАЛИ міжнародної науково-практичної інтернет-конференції CHERNIVTSI INTERNATIONAL MEDICAL CONFERENCE (СІМЕС). - м. Чернівці 02-03 червня 2017 р, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12882.
Full textKirsch, Florian [Verfasser]. "Economic aspects of disease management programs in chronic diseases / Florian Kirsch." München : Verlag Dr. Hut, 2018. http://d-nb.info/1164293648/34.
Full textVerma, Anju. "Ontology based personalized modeling for chronic disease risk evaluation and knowledge discovery an integrated approach : a thesis submitted to Auckland University of Technology in fulfilment of the requirements for [the] degree of Doctor of Philosophy (PhD), 2009 /." Click here to access this resource online, 2009. http://hdl.handle.net/10292/784.
Full textPereira, Filipa Alexandra Antunes Vences de Matos. "Patient associations: raising awareness on chronic diseases." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16582.
Full textThe patient associations assume a significant role in representing the patients’ rights, sharing information on the diseases, accessing the available resources, maintaining important interactions with other relevant stakeholders and facing challenges. These organizations provide an important support not only to the patients, but also to their families and friends, who are most of the times their direct caregivers. Currently, the patient empowerment has been highly discussed. This project aims to demonstrate in five different clinical disorders what are the motivations, the objectives, the activities, the involvement with other stakeholders and the challenges assumed by the correspondent patient associations. The result of this project allowed to conclude that the significant prevalence of chronic diseases has been introducing changes into the healthcare systems and national disease programmes. Simultaneously, the patients’ ownership has been increasing, contributing to a more participated role near the healthcare professionals and to a more conscious decision regarding the available therapeutics. Patient associations represent these patients and act in critical areas, such as, social, clinical, research, training, education and advocacy.
As associações de doentes assumem um papel fundamental na representação dos direitos dos pacientes, na divulgação de informação acerca das doenças, no acesso aos recursos disponíveis, no relacionamento com os vários intermediários e nos desafios a enfrentar. Estas associações prestam não só um grande apoio aos doentes, como também aos seus familiares e amigos, que são na maior parte das vezes os seus cuidadores diretos. Atualmente, a capacitação de doentes tem vindo a ser bastante discutida. Este projeto pretende demonstrar em cinco quadros clínicos distintos, quais as motivações presentes, os objetivos, as atividades realizadas, o envolvimento com outros stakeholders e os desafios enfrentados pelas respetivas associações de doentes. O resultado deste trabalho permitiu concluir que a prevalência significativa de doenças crónicas tem introduzido alterações nos sistemas de saúde e nos planos nacionais de doenças. Em simultâneo, a responsabilidade dos pacientes tem vindo a aumentar, contribuindo para um posicionamento cada vez mais participativo junto dos profissionais de saúde e para uma tomada de decisão mais consciente em relação às terapêuticas disponíveis. As associações de doentes dão voz a estes pacientes e atuam em áreas críticas, tais como, a área social, emocional, clínica, de investigação, de formação, de educação e de defesa e representatividade de direitos e benefícios.
White, Joanna D. "Investigations into feline chronic kidney disease." Thesis, The University of Sydney, 2010. https://hdl.handle.net/2123/28931.
Full textRamzan, Naveen, Shimin Zheng, Hemang Panchal, Edward Leinaar, Christian Nwabueze, and Timir K. Paul. "Investigating The Association Between Chronic Kidney Disease and Clinical Outcomes." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/21.
Full textAlaei, Shahmiri Fariba. "The potential association between thiamin, hyperglycemia and chronic diseases." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1209.
Full textMaimela, Eric. "Development of an integrated, evidence-based management model for chronic non-communicable diseases and their risk factors, in a rural area of Limpopo Province, South Africa." Thesis, University of Limpopo, 2016. http://hdl.handle.net/10386/1732.
Full textBackground: Chronic disease management (CDM) is an approach to health care that keeps people as healthy as possible through the prevention, early detection and management of chronic diseases. This approach offers holistic and comprehensive care, with a focus on rehabilitation, to achieve the highest level of independence possible for individuals.The aim of this study was to develop an integrated, evidence-based model for the management of chronic non-communicable diseases in a rural community of the Limpopo Province, South Africa. Methods: The study was conducted at Dikgale Health and Demographic Surveillance System (HDSS) site is situated in Capricorn District of Limpopo Province in South Africa. This study followed mixed methods methodology with an aim on integrating quantitative and qualitative data collection and analysis in a single study to develop an intervention program in a form of model to improve management of chronic diseases in a rural area. Therefore, this included literature review and WHO STEPwise approach to surveillance of NCD risk factors for quantitative techniques and focus group discussions, semi-structures interviews and quality circles for qualitative techniques. In the surveillance of NCD risk factors standardised international protocols were used to assess behavioural risk factors (smoking, alcohol consumption, fruit and vegetable consumption, physical activity) and physical characteristics (weight, height, waist and hip circumferences, and blood pressure). A purposive sampling method was used for qualitative research to determine knowledge, experience and barriers to chronic disease management in respect of patients, nurses, community health workers (CHWs), traditional health practitioners (THPs) and managers of chronic disease programmes. Data were analysed using STATA 12 for Windows, INVIVO and Excel Spreadsheets. Results: The study revealed that epidemiological transition is occurring in Dikgale HDSS. This rural area already demonstrates a high burden of risk factors for non-communicable diseases, especially smoking, alcohol consumption, low fruit and vegetable intake, physical inactivity, overweight and obesity, hypertension and dyslipidaemia, which can lead to cardiovascular diseases. The barriers mostly mentioned by the nurses, patients with chronic disease, CHWs and THPs include lack of knowledge of NCDs, shortages of medication and shortages of nurses in the clinics which cause patients to stay for long periods of time in a clinic. Lack of training on the management of chronic diseases, supervision by the district and provincial health managers, together with poor dissemination of guidelines, were contributing factors to lack of knowledge of NCDs management among nurses and CHWs. THPs revealed that cultural insensitivity on the part of nurses (disrespect) makes them unwilling to collaborate with the nurses in health service delivery. x The model developed in this study which was the main aim of the study describes four interacting system components which are health care providers, health care system, community partners and patients with their families. The main feature of this model is the integration of services from nurses, CHWs and THPs including a well-established clinical information system for health care providers to have better informed patient care. The developed model also has an intervention such as establishment of community ambassadors. Conclusion: Substantially high levels of the various risk factors for NCDs among adults in the Dikgale HDSS suggest an urgent need for adopting healthy life style modifications and the development of an integrated chronic care model. This highlights the need for health interventions that are aimed at controling risk factors at the population level in order to slow the progress of the coming non-communicable disease epidemic. Our study highlights the need for health interventions that aim to control risk factors at the population level, the need for availability of NCD-trained nurses, functional equipment and medication and a need to improve the link with traditional healers and integrate their services in order to facilitate early detection and management of chronic diseases in the community. The developed model will serve as a contribution to the improvement of NCD management in rural areas. Lastly, concerted action is needed to strengthen the delivery of essential health services in a health care system based on this model which will be tasked to organize health care in the rural area to improve management and prevention of chronic illnesses. Support systems in a form of supervisory visits to clinics, provision of medical equipments and training of health care providers should be provided. Contribution from community partners in a form of better leadership to mobilise and coordinate resources for chronic care is emphasized in the model. This productive interaction will be supported by the district and provincial Health Departments through re-organization of health services to give traditional leaders a role to take part in leadership to improve community participation.
Medical Science Department, University of Limpopo in South Africa,International Health Unit, and Antwerp University
LORE', BRUNO. "Chronic oral diseases: clinical and therapeutic approach." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2016. http://hdl.handle.net/2108/201776.
Full text潘建基 and Kin-kee Pun. "Carbohydrate metabolism in chronic renal and liver disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31981276.
Full textBaril, Jacinthe. "Interaction between circulatory and respiratory exercise adaptation in chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF)." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97901.
Full textZeddies, Andréa McBride. "Chronic illness in context examining sociocultural factors in women's experience of lupus /." Access restricted to users with UT Austin EID, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037033.
Full textRoberts, Della Kim. "The family experience with chronic obstructive pulmonary disease." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24422.
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Nursing, School of
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Håkansson, Niclas. "Occupational exposure to electromagnetic fields and chronic diseases /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-719-3/.
Full textCurrie, D. F. "Assessment of genetic susceptibility ot chronic renal diseases." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546036.
Full textChooi, Yu Chung. "Acculturation, Dietary Intake and Chronic Diseases Among Latinos." Thesis, Howard University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10190826.
Full textThe purpose of this study was to examine the relationships of acculturation [language(s) usually spoken at home, and length of residence in the United States (US)] of Mexican-American and other Hispanics to dietary intakes, as well as to chronic diseases such as overweight/obesity, diabetes, hypertension and coronary heart disease (CHD) risk.
The study was based on data extracted from the 2011-2012 National Health and Nutrition Examination Survey (NHANES). A total of 860 Hispanic subjects aged 40 years or more were utilized in the study. Data were analyzed using SUDAAN statistical software. Statistical procedures used to address the study objectives were t-tests and chi-square tests.
The findings demonstrated that language usually spoken at home (English more than Spanish or only English) was associated with higher intakes of total fat, total saturated fat, total monounsaturated fat, total polyunsaturated fat and sodium compared with the other groups. However, greater length of residence in the US was associated with lower intakes of energy, total fat, saturated fat, and sodium; and higher fiber intakes. Overweight and obesity were associated with greater length of residence in the US and language spoken at home (English and Spanish equally). Diabetes and hypertension had no significant relationships with length of residence in the US or language usually spoken at home. Greater length of residence in the US was associated with greater risk of CHD.
Boonarpha, N. "Choroidal structure and function in chronic retinal diseases." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001786/.
Full textVickers, Margaret H. (Margaret Heather) 1962, of Western Sydney Nepean University, and Faculty of Commerce. "Life and work with 'invisible' chronic illness (ICI) :authentic stories of a passage through trauma - a Heideggerian, Hermeneutical, phenomenological, multiple-case, exploratory analysis." THESIS_FC_XXX_Vickers_M.xml, 1997. http://handle.uws.edu.au:8081/1959.7/826.
Full textDoctor of Philosophy (PhD)
Aravinthan, Aloysious Dominic. "Hepatocyte senescence in chronic liver disease." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708050.
Full textWong, Siu-lan. "Statistical methods in studying the aetiology of Chronic diseases /." [Hong Kong] : University of Hong Kong, 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12354430.
Full textCruz, Lebron Angelica Iris. "THE GUT MICROBIOME IN HUMAN GASTROINTESTINAL DISEASES: CHRONIC OPIOID USE & INFLAMMATORY BOWEL DISEASE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1607681399971656.
Full textYarkiner, Zalihe. "Developing longitudinal models for monitoring chronic diseases in computerised general practice (GP) records : a case study in chronic kidney disease (CKD)." Thesis, Kingston University, 2015. http://eprints.kingston.ac.uk/34536/.
Full textLindholm, Michelle Marie. "Chronic childhood disease and child abuse." CSUSB ScholarWorks, 1998. https://scholarworks.lib.csusb.edu/etd-project/1559.
Full textAcharyya, Swarnali. "Elucidating molecular mechanisms of muscle wasting in chronic diseases." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180096565.
Full textSimadibrata, Marcellus. "Small bowel diseases causing chronic diarrhea in Indonesian people." Jakarta : Amsterdam : Publishing Unit of Internal Medicine, Faculty of Medicine, University of Indonesia ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/86145.
Full textArsenescu, Violeta. "ROLE OF ARYL HYDROCARBON RECEPTOR IN CHRONIC INFLAMMATORY DISEASES." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/772.
Full textLai, Ching-lung, and 黎靑龍. "Chronic hepatitis B-related liver diseases in the Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31981501.
Full textWong, Siu-lan, and 黃小蘭. "Statistical methods in studying the aetiology of Chronic diseases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31207984.
Full textLai, Ching-lung. "Chronic hepatitis B-related liver diseases in the Chinese." Hong Kong : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13814060.
Full textBethune, Jörn [Verfasser]. "Network-Assisted Analysis of Chronic Inflammatory Diseases / Jörn Bethune." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1118499875/34.
Full textChakrabarti, Shubro. "Mechanisms of fibrosis in feline chronic kidney disease." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572451.
Full textHampton, Jenaneta Sue. "Women, spirituality, and chronic illness." Thesis, Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/hampton/HamptonJ1204.pdf.
Full textSuemanotham, Namphung. "The role of cyclooxygenase enzymes in feline chronic kidney disease." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559010.
Full textClark, Laura Elizabeth. "The epidemiology of chronic kidney disease in Grampian." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33407.
Full textChoate, Radmila. "ESTIMATING DISEASE SEVERITY, SYMPTOM BURDEN AND HEALTH-RELATED BEHAVIORS IN PATIENTS WITH CHRONIC PULMONARY DISEASES." UKnowledge, 2019. https://uknowledge.uky.edu/epb_etds/22.
Full textWong, Germaine. "Cancer and chronic kidney disease." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28229.
Full textGraves, Carolyn Mary. "Comparing parents' and nurses' identification and prioritization of parental needs in the context of caring for children with chronic conditions." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29728.
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L'Italien, Matthew R. "Longitudinal Nutrition Risk Assessment of the Elderly." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/LItalienMR2004.pdf.
Full textElwell-Sutton, Timothy Mark. "Inequality, inequity and the rise of non-communicable disease inChina." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hub.hku.hk/bib/B5016272X.
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Community Medicine
Doctoral
Doctor of Philosophy
Murphy, Georgina Anne Veronica. "Chronic non-communicable diseases and risk factors in rural Uganda." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707995.
Full textCantero, Recasens Gerard 1984. "Cellular Ca2+ homeostasis in the pathophysiology of chronic respiratory diseases." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/104537.
Full textEl Calci és un segon missatger intracel·lular en tots els tipus cel·lulars i la cascada de senyalització generada pel calci és una via de senyalització cel·lular clau per moltes funcions sistèmiques. En els pulmons, la majoria d’estímuls activadors produeixen un increment del calci intracel·lular, el qual és indispensable pel funcionament correcte de les vies respiratòries; i, per tant, una desregulació d’aquesta via de senyalització porta a diferents situacions patològiques. Aquesta Tesi té com a objectiu entendre la relació entre l’homeòstasi del calci intracel·lular i les malalties respiratòries cròniques, com per exemple, l’asma. Hem estudiat tres processos diferents implicats en l’homeòstasi del calci i el seu rol en la fisiopatologia de l’asma: 1) Hem demostrat que hi ha una associació genètica entre un defecte en l’entrada de calci via TRPV1 i un dels trets característics de l’asma, la tos; 2) també hem trobat que l’ORMDL3, que havia estat associat amb l’asma, és un modulador de l’homeòstasi del calci i de la UPR; i 3) hem aportat un nou mecanisme de classificació en el Golgi depenent de Ca++ per a proteïnes que uneixen calci i que seran secretades.
Damera, Gautam V. "Molecular mechanisms of mucus hypersecretion in chronic airway obstructive diseases." Oklahoma City : [s.n.], 2006.
Find full textHenriksson, Freddie. "Economic aspects of chronic diseases : multiple sclerosis and diabetes mellitus /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-5023-7/.
Full textAdeogun, Oluseun. "Informatics for devices within telehealth systems for monitoring chronic diseases." Thesis, Cranfield University, 2011. http://dspace.lib.cranfield.ac.uk/handle/1826/6493.
Full textTarlow, Joanna Karen. "Interleukin-1 receptor antagonist gene polymorphism in chronic inflammatory diseases." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296761.
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