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Dissertations / Theses on the topic 'Chromatin'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Jurisic, Anamarija. "Développement d'une approche méthodologique basée sur la biotinylation in vivo de protéines de la chromatine - Application à l’étude des interactions entre des domaines chromosomiques et une protéine de l'enveloppe nucléaire dans des cellules individuelles." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS349.

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Les arguments en faveur d’un rôle important de l'architecture des chromosomes en interphase pour la régulation des gènes et la maintenance du génome s’accumulent rapidement. Au cours de l'interphase, les chromosomes sont positionnés de façon non aléatoire l’un par rapport à l'autre et fournissent ainsi des points de repère nucléaires. Deux types d'interactions contribuent probablement à ce positionnement non aléatoire: (i) des domaines subchromosomiques interagissent avec des structures nucléaires telles l'enveloppe nucléaire (EN) et (ii) des interactions intrachromosomiques s’établissent entr
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2

Gasser, Regula. "Active chromatin /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10389.

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3

Belaghzal, Houda. "Chromatin Interaction Dynamics Revealed by Liquid Chromatin Hi-C." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1046.

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Development and application of genomic approaches based on 3C methods combined with increasingly powerful imaging approaches have enabled high-resolution genome-wide analysis of the spatial organization of chromosomes in genome function. In this thesis, I first describe an updated protocol for Hi-C (Hi-C 2.0), integrating recent improvements that significantly contribute to the efficient and high-resolution capture of chromatin interactions. Secondly, I present an assessment of the epigenetic landscape and chromosome conformation around the MYC gene in acute myeloid leukemia (AML) cells before
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4

Besnard, Emilie. "Modifications de l'organisation de la chromatine liées à l’entrée en sénescence et son impact sur la réplication du génome." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T008.

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L'entrée en sénescence, considérée comme un arrêt irréversible du cycle, se caractérise par une modification de l'organisation de la chromatine formant de véritables foyers d' hétérochromatine spécifiques (SAHF) coordonnée à une modification d'expression génique et à un déclin progressif de la compétence à répliquer le génome. Ainsi, au cours de ma thèse, j'ai voulu comprendre en quoi ces changements d'organisation du génome pouvaient influer sur la distribution et l'activation des origines d e réplication lors de l'entrée en sénescence réplicative ou déclenchée de façon prématurée par l'inhib
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Clynes, David Alexander. "Signalling to chromatin." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496840.

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6

Jang, Boyun. "Analysis of chromatin targeting modules in the chromatin remodelling enzyme NURF." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5204/.

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Drosophila nucleosome remodelling factor (NURF) is one of the founding members of the ISWI family of ATP-dependent chromatin remodelling enzymes and mediates energy-dependent nucleosome sliding leading to transcription regulation. In previous work (Wysocka et al., 2006), NURF was shown to be recruited to gene targets by binding specific histone modifications. The largest subunit of NURF, NURF301, contains a bromodomain and three PHD finger domains that have the ability to recognize specific histone modifications. Here we determine the histone binding-specificities of these domains, and how NUR
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7

Marie, Corentine. "The role of Chd7 & Chd8 chromatin remodelers in oligodendrogenesis and (re)myelination." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066365/document.

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Les oligodendrocytes (OLs) sont les cellules myélinisantes du système nerveux central, s’enroulant autour des axones et permettant la conduction saltatoire du potentiel d’action. Dans la Sclérose en Plaques, des gaines de myélines sont détruites et l’efficacité de la remyélinisation par les précurseurs d’oligodendrocytes (OPCs) diminue avec la progression de la maladie. Une meilleure compréhension du mécanisme qui contrôle la génération des OPCs et leur différentiation est donc essentielle pour développer des thérapies efficaces de remyélinisation. L’oligodendrogenèse, qui comprend les étapes
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8

Beurton, Flore. "Étude de l’interaction physique et fonctionnelle entre le complexe histone méthyltransférase SET-2/SET1 et le complexe histone déacétylase SIN-3S dans l’embryon de C. elegans." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEN017.

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Les complexes histones méthyltransférases SET1, hautement conservés de la levure aux mammifères, sont ciblés aux régions promotrices par la protéine CFP1/CXXC, résultant en l’implémentation de la méthylation de la lysine 4 de l’histone H3 (H3K4me), modification post-traductionnelle influençant l’expression des gènes selon le contexte chromatinien. La présence de plusieurs complexes SET1 distincts dans différents systèmes modèles eucaryotes a compliqué l’étude de leurs fonctions dans un contexte développemental. Caenorhabditis elegans contient une seule protéine homologue de SET1, SET-2, et d’u
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9

Nothjunge, Stephan [Verfasser], and Stefan [Akademischer Betreuer] Günther. "Chromatin-Interaktionen in Kardiomyozyten." Freiburg : Universität, 2019. http://d-nb.info/1185390979/34.

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10

Little, Gillian H. "Stat5 binding to chromatin." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/12435.

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Expression of milk proteins including β-lactoglobulin is controlled by prolactin activation of the transcription factor Stat5 via the Janus kinase/Signal transducer and activator of transcription (Jak/STAT) pathway. Stat5 has previously been shown to tetramerise where binding sites are tandemly linked and the proximity of these binding sites appears to be important for these interactions. This work and previous large scale mapping of the β-lactoglobulin promoter shows that the dyad of a strongly positioned nucleosome lies at -184 bp from the transcription start on the promoter of the β-lactogl
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11

Arnold, Christian. "The Eukaryotic Chromatin Computer." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-137584.

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Eukaryotic genomes are typically organized as chromatin, the complex of DNA and proteins that forms chromosomes within the cell\\\'s nucleus. Chromatin has pivotal roles for a multitude of functions, most of which are carried out by a complex system of covalent chemical modifications of histone proteins. The propagation of patterns of these histone post-translational modifications across cell divisions is particularly important for maintenance of the cell state in general and the transcriptional program in particular. The discovery of epigenetic inheritance phenomena - mitotically and/or meiot
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12

Clement, Camille. "Rôle du chaperon d'histone ASF1 dans le recyclage des histones parentales pendant la réplication de l'ADN." Electronic Thesis or Diss., Paris Sciences et Lettres (ComUE), 2018. https://theses.hal.science/tel-02518693.

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Chez les eucaryotes, l’ADN s’enroule autour de protéines appelées histones pour former la chromatine. Cette structure permet, d’une part, de compacter le génome dans le noyau, mais également de réguler son expression. En effet, les histones sont porteuses d’information dite « épigénétique » : elles existent sous différentes formes, les variants d’histone, et peuvent porter des modifications post-traductionnelles. La présence de tels variants et modifications organise le génome en domaines au statut transcriptionnel différent.La réplication de l’ADN déstabilise la structure chromatinienne, et r
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13

Meyer, Sam. "Multiscale modeling of DNA, from double-helix to chromatin." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00756315.

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In the nucleus of eukaryotic cells, DNA wraps around histone proteins to form nucleosomes, which in turn associate in a compact and dynamic fiber called chromatin. The physical properties of this fiber at different lengthscales, from the DNA double-helix to micrometer-sized chromosomes, are essential to the complex mechanisms of gene expression and its regulation. The present thesis is a contribution to the development of physical models, which are able to link different scales and to interpret and integrate data from a wide range of experimental and computational approaches. In the first part
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14

Boskovic, Ana. "Study of histone variants and chromatin dynamics in the preimplantation mouse embryo." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ034/document.

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Comment le zygote acquiert la totipotence à partir de deux cellules complètement différenciées, et comment les décisions du destin cellulaire sont faites plus tard dans le développement sont des questions biologiques essentielles. Les études menées au cours de la première partie de mon doctorat ont contribué à l'annotation de la composition de la chromatine embryonnaire en ce qui concerne les variantes des histones et des modifications post-traductionnelles. L'expression ectopique de H2A.Z après la fécondation réduit la progression du développement, ce qui suggère que l'absence de H2A.Z au déb
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15

Ciabrelli, Filippo. "Stable transgenerational inheritance of alternative chromatin states in Drosophila melanogaster." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT034.

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L’héritage épigénétique transgénérationnelle est un phénomène très controversé, selon lequel un phénotype non-génétiquement déterminé peut être transmis à la génération suivante. Jusqu'à présent, ce mode de transmission a été décrit dans quelques cas et il a été suggéré que les composants de la chromatine peuvent être impliqués, y compris des protéines du groupe Polycomb, qui agissent comme des répresseurs de gènes clés du développement et coordonnent la différenciation cellulaire et la prolifération. Les mécanismes moléculaires à la base du rôle de la répression génique Polycomb-dépendante à
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16

Kirstein, Nina Danielle. "Chromatin-dependent pre-replication complex positioning and activation in mammals." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT005/document.

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Chaque division cellulaire requiert une duplication précise du génome. Des dizaines de milliers de sites d’initiation de la réplication d’ADN (origines de réplication) sont impliqués dans la réplication complète du génome humain. L’activation des origines de réplication est régulée précisément et des études génomiques extensives ont démontré la présence de caractéristiques génomiques associées à l’activation des origines de réplication. Le complexe de pré-réplication (pre-RC) est la base de l’initiation de la réplication et consiste en deux sous-complexes majeurs : l’ « origin recognition comp
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17

Teano, Gianluca. "Functional interplays between linker histone H1 variants and chromatin landscape in Arabidopsis thaliana." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASB003.

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Les plantes sont caractérisées par une remarquable plasticité développementale. En vertu de leur mode de vie sessile, elles sont capables d'adaptations phénotypiques rapides en réponse à des signaux environnementaux. En particulier, les plantes ont la capacité de détecter les conditions de lumière par de multiples photorécepteurs et utilisent cette information pour adapter leur morphologie et leur physiologie à un environnement changeant. Par exemple, la première perception de la lumière par des jeunes plantules, émergeant du sol, induit des changements profonds dans l'expression des gènes qui
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18

Santos, Barriopedro Irene. "Role of SIRT6 in Chromatin." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/292363.

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Chromatin compaction is regulated by different factors, among them histone posttranslational modifications. There are different histone modifications, and among them, acetylation and methylation of lysine residues. Acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), enzymes that catalyze addition and removal, respectively, of acetyl groups from histone lysine residues. Among the four classes of HDACs, the class III which correspond to the members of the Sir2 family or Sirtuins are quite unique. They participate in the response to a wide varie
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19

Maier, Michael 1983. "Origin of chromatin anaphase bridges." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/565807.

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Successful chromosome segregation is crucial for the survival of a cell and to avoid diseases such as cancer. Anaphase bridges are a type of segregation defect that can arises from structurally compromised chromosomes. Little is known about the mechanisms that normally prevent them. In this study I screened for genes that normally prevent anaphase bridges in order to learn more about their origin. I found anaphase bridges to arise in replication mutants and it is possible to trigger these bridges by exposing cells to replication stress. Thus, impaired replication is one cause for anaphase brid
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20

Möbius, Wolfram. "Physical aspects of chromatin constituents." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-119872.

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21

Hoffbeck, Anne-Sophie. "Chromatin structure and DNA repair." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ104/document.

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Notre génome est continuellement endommagé par des agents provoquant des lésions de l’ADN. Les cassures doubles brins de l’ADN (CDBs) sont les lésions les plus dangereuses. En effet, une CDB mal réparée peut mener à des aberrations de l’ADN pouvant conduire à l’apparition d’un cancer. Dans le but d’éviter les effets délétères des CDBs, nos cellules ont développé une voie de signalisation, nommée réponse aux dommages de l’ADN (RDA), permettant la détection des cassures et l’activation des points de contrôle du cycle cellulaire afin d’arrêter le cycle pendant la réparation des CDBs. Une des cara
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22

Koutzamani, Elisavet. "Chromatin, histones, and epigenetic tags." Doctoral thesis, Linköping : Linköping University, 2006. http://www.bibl.liu.se/liupubl/disp/disp2006/med960s.pdf.

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23

Gelius, Birgitta. "Chromatin remodelling and gene regulation /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-16-1/.

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24

Lo, Wing Ip Anthony. "Human centromeric and neocentromeric chromatin /." Connect to thesis, 2000. http://eprints.unimelb.edu.au/archive/00000771.

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25

Dent, Myrna Alexandra Roberta. "Studies of brain chromatin structure." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315053.

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26

Halls, K. S. "Chromatin modifiers and their function." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599879.

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The aim of my work was to investigate enzymes that potentially modify chromatin and identify possible functions. SET domain containing proteins can catalyse histone lysine methylation. Riz and Blimp are members of the PRDM subfamily of the SET-domain protein group. PRDM proteins contain amino acid substitutions at conserved sites within the SET domain and it is thought that these mutations may inactivate histone methyltransferase (HMT) activity. I have investigated potential functions for this subfamily. My results suggest that the Riz and Blimp bind and demethylate histones <i>in vitro</i>. S
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27

Dawson, M. A. F. "JAK-STAT signalling at chromatin." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598423.

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The aim of my work was to explore the possibility that the mammalian JAK2 signalling pathway influences the structure and function of chromatin. I have demonstrated that JAK2 is present in the nucleus of both human haematopoietic cell lines and primary cells. My results suggest that JAK2 functions as a histone tyrosine kinase and phosphorylates histone H3 at tyrosine-41 (H3Y41). This novel histone modification, the first described tyrosine phosphorylation on any of the non-variant histones, regulates the binding of heterochromatin protein 1-alpha (HP1α) at a new binding site on chromatin. HP1α
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Pusch, Miriam. "Proteomics of newly assembled chromatin." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-180964.

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29

Goldberg, Martin William. "Histone ubiquitination and chromatin structure." Thesis, Liverpool John Moores University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253137.

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30

Rossignol, Pascale. "Characterisation of chromatin-associated proteins." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426574.

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31

Lambert, S. F. "Lysine-DNA interactions in chromatin." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332194.

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32

Verreault, Alain. "Transcriptionally competent and repressed chromatin." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318267.

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33

McArthur, Michael. "Chromatin structure and DNA methylation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627534.

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34

Chandra, Tamir. "Chromatin dynamics in cellular senescence." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610079.

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35

Zegerman, Philip Alexander. "Characterization of chromatin modifying factors." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620279.

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36

Wolf, Daniel. "Chromatin modifying enzymes and transcription." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619707.

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37

Fisher, Alex. "Chromatin remodelling in light signalling." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/29749.

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Plants selectively deplete incident light of red (R) wavelength, relative to far-red (FR) wavelength light. Consequently, the relative proportions of R and FR (R:FR ratio) act as an indicator of surrounding vegetation and plants, via the phytochrome photoreceptors, are capable of detecting this. Low R:FR ratio is interpreted as surrounding competition and results in plants eliciting, what is known as, the shade avoidance response. This involves a host of both phenotypic and molecular changes, including increased hypocotyl growth, earlier flowering time and changes in gene expression. The funda
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38

Fennessy, Ross. "Chromatin dynamics during DNA replication." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/7898ad5c-ea45-4ce5-a6b7-9b858615368e.

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The primary level of chromatin organisation consists of arrays of nucleosomes that are present across the genetic template. Advances in the post genomics era have made it possible to determine the positions of nucleosomes genome-wide where it has been observed that nucleosomes adopt a distinct organisation with respect to genetic and trans-binding elements. Amongst the best studied of these is the transcription start site where it has been observed that genic nucleosome locations are well maintained with respect to promoters. DNA and chromatin replication are coupled processes whereby chromati
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Furlan, Cristina. "Quantitative proteomics of human chromatin." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/17992.

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The work presented in this thesis aims at unravelling human chromatin composition by quantitative proteomics to outline the functional and structural changes occurring during the life of human cells. Chromatin is the structure formed by proteins and RNAs interacting with the genetic material. At present, chromatin is not well defined. It is not easy to investigate either the composition of its constituent proteins or how this arrangement changes. We set out to analyse the chromatin composition changes occurring during the cell cycle. Our procedure couples a SILAC mass spectrometry-based approa
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Topal, Salih. "Chromatin Dynamics Regulate Transcriptional Homeostasis." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1062.

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Eukaryotic promoters are inherently bidirectional and allow RNA Polymerase II to transcribe both coding and noncoding RNAs. Dynamic disassembly and reassembly is a prominent feature of nucleosomes around eukaryotic promoters. While H3K56 acetylation (H3K56Ac) enhances turnover events of these promoter-proximal nucleosomes, the chromatin remodeler INO80C ensures their proper positioning. In my dissertation, I explore how chromatin dynamics regulate transcriptional homeostasis. In the first part, I investigate the role of H3K56Ac on the nascent transcriptome throughout the eukaryotic cell cycle.
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VonHandorf, Andrew P. "Cr(VI) Disrupts Chromatin Architecture." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595243461574043.

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Riedmann, Caitlyn M. "THE DYNAMIC NATURE OF CHROMATIN." UKnowledge, 2017. http://uknowledge.uky.edu/biochem_etds/31.

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Eukaryotic organisms contain their entire genome in the nucleus of their cells. In order to fit within the nucleus, genomic DNA wraps into nucleosomes, the basic, repeating unit of chromatin. Nucleosomes wrap around each other to form higher order chromatin structures. Here we study many factors that affect, or are effected by, chromatin structure including: (1) how low-dose inorganic arsenic (iAs) changes chromatin structures and their relation to global transcription and splicing patterns, and (2) how chromatin architectural proteins (CAPs) bind to and change nucleosome dynamics and DNA targ
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Rafique, Sehrish. "Chromatin organisation in breast cancer." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11722.

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Epigenetic misregulation of gene expression is known to be an important feature in cancer. This has mainly been studied at the level of changes in DNA methylation and histone modifications at individual genes. In this thesis I have set out to investigate whether there are long-range changes in chromatin structure linked to altered gene expression in breast cancer. From large published datasets, I used a computational approach to identify large genomic regions which are coordinately misregulated in breast cancer independent of copy number aberrations (genomic effects). I found 26 regions of co-
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Prasad, Amalthiya. "Base Excision Repair in Chromatin." ScholarWorks @ UVM, 2008. http://library.uvm.edu/dspace/bitstream/123456789/180/1/amalthiyprasadfinal.pdf.

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45

Patankar, S. M. "Condensed chromatin in higher plants." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3286.

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46

Galic, Hrvoje. "Heterochromatin dynamics upon release from stationary phase in budding yeast." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT006/document.

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La complexe protéique Sir (Silent Information Regulator) de la levure bourgeonnante est l’acteur principal dans la formation de l’hétérochromatine, qui provoque l’atténuation de l’expression génique par un mécanisme épigénétique. Le complexe Sir lié à la chromatine maternelle est démonté lors de la réplication génomique et puis réformé sur les deux brins nouvellement répliqué. La dynamique de maintien de Sir sur la chromatine pendant le cycle cellulaire et dans de variables conditions de croissance n’est pas bien comprise. Pour comprendre comment la structure chromatinienne telle que l’hétéroc
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Robinson, Mark. "Exploring the roles of chromatin remodelers in regulating chromatin organisation and transcription in Dictyostelium discoideum." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/99875/.

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Nucleosomes comprise the most basic repeating unit of chromatin and provide hubs for the regulation of DNA transcription, replication and repair. ATPase chromatin remodelling complexes establish nucleosome occupancy, positioning and structure in a dynamic fashion to allow fine-tuning of protein-DNA interactions. The ISWI and CHD families of remodelers possess the ability to sample DNA linker length between nucleosomes and space nucleosomes evenly. How these spacing remodelers combine their functions to maintain phasing of nucleosomal arrays, and re-organise these arrays during development rema
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BENDANDI, ARTEMI. "Modelling Electrostatic Interactions and Solvation in Chromatin: from the single nucleosome towards the chromatin fibre." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1042960.

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Chromatin is a complex of proteins and DNA found in the nuclei of eukaryotic cells. It reinforces the DNA and its topology tunes DNA transcription and gene expression. It is formed by nucleosomes, structures composed of an octameric protein core and approximately 147 base pairs of DNA. Chromatin is an extremely complex system, the behaviour of which is ruled by both mechanical and electrostatic factors that are depend on its structure, and biomolecular interactions occurring in the cell nucleus. In this thesis, I analyse chromatin compaction from an electrostatic perspective and focus on the r
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Zayed, Abdallah. "The role of chromatin remodelers in dopaminoceptive neurons." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS437.

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La libération d’hormone glucocorticoïde (GC) est une réponse physiologique à l’exposition au stress qui permet à l’organisme de faire face aux défis environnementaux. Bénéfique lors du travail, un dysfonctionnement de cette réponse adaptative est associé à de multiples pathologies, y compris les troubles psychiatriques. Le CG agit par la liaison avec leur récepteur glucocorticoïde (GR). Il a été démontré que GRD1Cre souris montaient réduit l’activité des neurones dopamines, diminue les réponses à la cocaïne et bloque l’aversion sociale induite par la défaite sociale répétée. GR peut contrôler
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50

Germier, Thomas. "Dynamique de la chromatine et transcription." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30376.

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La dynamique de la chromatine est affectée par les processus biologiques. Pour comprendre comment la physique de la chromatine et la biologie se repondent, nous avons besoin d'outils pour analyser la dynamique de la chromatine in vivo. Plusieurs systèmes existent pour marquer les loci d'ADN et déterminer efficacement leur position dans le noyau, mais ils présentent des inconvénients dans les cellules de mammifères lorsqu'il s'agit d'étudier le mouvement de la chromatine dans le contexte de processus biologiques. Cela est particulièrement vrai lorsqu'il s'agit de mécanismes où l'ADN doit être l
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