Academic literature on the topic 'Chong Lim Ng'

Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has affected not only the control and management of infectious diseases, but also those of other diseases by deteriorating the general healthcare systems worldwide. In accordance with the suggestion by the WHO for postponement of non-urgent procedures, diagnosis and treatment strategies for the patients with malignancy have been changed. The aim of this study was to investigate the impact of COVID-19 pandemic on primary colorectal cancer (CRC) from multi-institutions in Korea. Methods: Medical records of consecutive patients with CRC between March 2019 and February 2021 in six university hospitals were reviewed. Recurrent diseases, admission for management of complications or enterostomy repair, and other pathologies than adenocarcinoma were excluded. Baseline characteristics and perioperative outcomes were compared after a cohort was divided into the two groups: before and after around March 2020, when the COVID-19 test has been mandatory for all admitted patients in most institutions. Treatment characteristics and pathologic outcomes were also compared between the two groups. Results: A total of 3895 patients with CRC admitted during the study period. After 454 patients were excluded, 1820 and 1621 patients were assigned to the pre-pandemic and pandemic groups. The proportion of patients who could not receive curative or palliative surgery for stage IV diseases was not different (88 vs. 91, P>0.999), and 3262 patients underwent surgery for primary CRC. Among them, the pandemic group showed more previous abdominal surgery (21.2% vs. 15.4%, P<0.001), higher preoperative CEA level (46.7 vs. 16.0 ng/mL, P=0.021), and less stent insertion for obstructive lesion (33% vs. 46.4%, P=0.043). There was no difference in sex, age, the ASA grade, and tumor location between the groups. Perioperative outcomes including operation time, operation method, operation type, and postoperative complication rates were not different, whereas more stoma formation was performed in the pandemic group (15.3% vs. 12.4%, P=0.024). Pathologic outcomes including TNM stage, tumor diameter, harvested lymph nodes, and lymphovascular invasion were not different. However, the pandemic group showed higher tendency of lymph node metastasis (44% vs. 40.6%, P=0.070) and more adjuvant chemotherapy (26.4% vs. 20.1%, P<0.001). Conclusions: Although a few factors indicated more advanced CRC, clinical features and perioperative outcomes of the patients in COVID-19 pandemic seemed not to be aggravated in Korea. The national healthcare system which was not shut down in the pandemic, and relatively small number of COVID-19 prevalence might influence these results, although patients’ access and medical checkup seemed to decrease slightly. The cause and effect of decreased medical access would be clarified by long-term follow up data. Citation Format: Yoon Dae Han, Jun Sang Shin, Sung Uk Bae, Woo Ram Kim, Dae Ro Lim, Chang Woo Kim. COVID-19 pandemic and clinicopathologic characteristics of colorectal cancer in Korea: A multicenter, retrospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6178.

The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. Available at: https://covid19.who.int/ [Accessed on 23 August 2020] Sim K, Chua HC. The psychological impact of SARS: a matter of heart and mind. CMAJ. 2004; 170:811e2. https://doi.org/10.1503/cmaj.1032003. Wu P, Fang Y, Guan Z, Fan B, Kong J, Yao Z, et al. The psychological impact of the SARS epidemic on hospital employees in China: exposure, risk perception, and altruistic acceptance of risk. Can J Psychiatr. 2009; 54:302e11. https://doi.org/10.1177/070674370905400504. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020; 395:912e20. https://doi.org/10.1016/S0140-6736(20)30460-8. Robertson E, Hershenfield K, Grace SL, Stewart DE. The psychosocial effects of being quarantined following exposure to SARS: a qualitative study of Toronto health care workers. Can J Psychiatr. 2004; 49:403e7. https://doi.org/10.1177/070674370404900612. Barbisch D, Koenig KL, Shih FY. Is there a case for quarantine? Perspectives from SARS to Ebola. Disaster Med Public Health Prep. 2015; 9:547e53. https://doi.org/10.1017/dmp.2015.38. Jeong H, Yim HW, Song YJ, Ki M, Min JA, Cho J, et al. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiol Health. 2016;38: e2016048. https://doi.org/10.4178/epih.e2016048. Liu X, Kakade M, Fuller CJ, Fan B, Fang Y, Kong J, et al. Depression after exposure to stressful events: lessons learned from the severe acute respiratory syndrome epidemic. Compr Psychiatr. 2012; 53:15e23. https://doi.org/10.1016/j.comppsych.2011.02.003 Chadda RK, Deb KS. Indian family systems, collectivistic society and psychotherapy. Indian J Psychiatry. 2013;55: S299‑ https://dx.doi.org/10.4103%2F0019-5545.105555. Grover S, Sahoo S, Mehra A, Avasthi A, Tripathi A, Subramanyan A, et al. Psychological impact of COVID‑19 lockdown: An online survey from India. Indian J Psychiatry. 2020; 62:354-62. https://doi.org/ 10.4103/psychiatry.IndianJPsychiatry _427_20. Hawkley LC, Cacioppo JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med. 2010; 40: 218–27. https://dx.doi.org/10.1007%2Fs12160-010-9210-8. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-13. https://doi.org/10.1016/S0140-6736(20)30211-7. Bhandari S, Sharma R, Singh Shaktawat A, Banerjee S, Patel B, Tak A, et al. COVID-19 related mortality profile at a tertiary care centre: a descriptive study. Scr Med. 2020;51(2):69-73. https://doi.org/10.5937/scriptamed51-27126. Baumeister RF, Leary MR. The need to belong: desire for interpersonal attachments as a fundamental human motivation. Psychol Bull. 1995; 117: 497–529. https://doi.org/10.1037/0033-2909.117.3.497. Caspi A, Harrington H, Moffitt TE, Milne BJ, Poulton R. Socially isolated children 20 years later: risk of cardiovascular disease. Arch Pediatr Adolesc Med. 2006; 160(8):805-11. https://doi.org/10.1001/archpedi.160.8.805. Eaker ED, Pinsky J, Castelli WP. Myocardial infarction and coronary death among women: psychosocial predictors from a 20-year follow-up of women in the Framingham Study. Am J Epidemiol. 1992; 135(8):854-64. https://doi.org/10.1093/oxfordjournals.aje.a116381. Luo Y, Hawkley LC, Waite LJ, Cacioppo JT. Loneliness, health, and mortality in old age: a national longitudinal study. Soc Sci Med. 2012 Mar; 74(6):907-14. https://dx.doi.org/10.1016%2Fj.socscimed.2011.11.028. Olsen RB, Olsen J, Gunner-Svensson F, Waldstrøm B. Social networks and longevity. A 14-year follow-up study among elderly in Denmark. Soc Sci Med. 1991; 33(10):1189-95. https://doi.org/10.1016/0277-9536(91)90235-5. Patterson AC, Veenstra G. Loneliness and risk of mortality: a longitudinal investigation in Alameda County, California. Soc Sci Med. 2010; 71(1):181-6. https://doi.org/10.1016/j.socscimed.2010.03.024. Savikko N, Routassalo P, Tilvis RS, Strandberg TE, Pitkalla KH. Predictors and subjective causes of loneliness in an aged population. Arch Gerontol Geriatrics. 2005; 41:3;223-33. https://doi.org/10.1016/j.archger.2005.03.002. Health Advisory for Elderly Population of India during COVID19. Available at: https://www.mohfw.gov.in/pdf/AdvisoryforElderlyPopulation.pdf [Accessed on 13 August 2020]. Dicks D, Myers R, Kling A. Uncus and amygdala lesions: effects on social behavior in the free-ranging rhesus monkey. Science. 1969; 165:69–71. https://doi.org/10.1126/science.165.3888.69. Kanai R, Bahrami B, Duchaine B, Janik A, Banissy MJ, Rees G. Brain structure links loneliness to social perception. Curr Biol. 2012; 22(20):1975-9. https://dx.doi.org/10.1016%2Fj.cub.2012.08.045. Bender AR, Daugherty A, Raz N. Vascular risk moderates associations between hippocampal subfield volumes and memory. J Cogn Neurosci. 2013; 25:1851–62. https://doi.org/10.1162/jocn_a_00435. Raz N. Diabetes: brain, mind, insulin–what is normal and do we need to know? Nat Rev Endocrinol. 2011; 7:636–7. https://doi.org/10.1038/nrendo.2011.149. Colcombe SJ, Erickson KI, Naftali R, Andrew GW, Cohen NJ, McAuley E, et al. Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci. 2003; 58:176–80. https://doi.org/10.1093/gerona/58.2.m176. Maass A, Düzel S, Goerke M, Becke A, Sobieray U, Neumann K, et al. Vascular hippocampal plasticity after aerobic exercise in older adults. Mol Psychiatry. 2015; 20, 585–93. https://doi.org/10.1038/mp.2014.114. Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, et al. Loneliness and Risk of Alzheimer Disease. Arch Gen Psychiatry. 2007;64(2):234–240. https://doi.org/10.1001/archpsyc.64.2.234. Kogan JH, Frankland PW, Silva AJ. Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 2000;10(1):47-56. https://doi.org/10.1002/(sici)1098-1063(2000)10:1%3C47::aid-hipo5%3E3.0.co;2-6. Yorgason JT, España RA, Konstantopoulos JK, Weiner JL, Jones SR. Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. Eur J Neurosci. 2013;37(6):1022-31. https://doi.org/10.1111/ejn.12113. Bledsoe AC, Oliver KM, Scholl JL, Forster GL. Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus. Brain Res Bull. 2011;85(3-4):117-22. https://dx.doi.org/10.1016%2Fj.brainresbull.2011.03.003. Lukkes JL, Engelman GH, Zelin NS, Hale MW, Lowry CA. Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res. 2012; 1443:1-17. https://dx.doi.org/10.1016%2Fj.brainres.2012.01.005. Ago Y, Araki R, Tanaka T, Sasaga A, Nishiyama S, Takuma K, et al. Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice. Neuropsychopharmacology. 2013; 38(8):1535-47. https://doi.org/10.1038/npp.2013.52. Veenema AH. Early life stress, the development of aggression and neuroendocrine and neurobiological correlates: what can we learn from animal models? Front Neuroendocrinol. 2009;30(4):497-518. https://doi.org/10.1016/j.yfrne.2009.03.003. Zhao X, Sun L, Jia H, Meng Q, Wu S, Li N, et al. Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(7):1173-1177. https://doi.org/10.1016/j.pnpbp.2009.06.016. Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, et al. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 2010;168(2):371-86. https://dx.doi.org/10.1016%2Fj.neuroscience.2010.04.007. Ghasemi M, Phillips C, Trillo L, De Miguel Z, Das D, Salehi A. The role of NMDA receptors in the pathophysiology and treatment of mood disorders. Neurosci Biobehav Rev. 2014; 47:336-358. https://doi.org/10.1016/j.neubiorev.2014.08.017. Olivenza R, Moro MA, Lizasoain I, Lorenzo P, Fernández AP, Rodrigo J, et al. Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex. J Neurochem. 2000;74(2):785-791. https://doi.org/10.1046/j.1471-4159.2000.740785.x. Maeng S, Zarate CA Jr, Du J, Schloesser RJ, McCammon J, Chen G, et al. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry. 2008;63(4):349-352. https://doi.org/10.1016/j.biopsych.2007.05.028. Kalia LV, Kalia SK, Salter MW. NMDA receptors in clinical neurology: excitatory times ahead. Lancet Neurol. 2008;7(8):742-755. https://dx.doi.org/10.1016%2FS1474-4422(08)70165-0. Waxman EA, Lynch DR. N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease. The Neuroscientist. 2005; 11(1), 37–49. https://doi.org/10.1177/1073858404269012. Hermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiol Behav. 2011;104(2):354-9. https://dx.doi.org/10.1016%2Fj.physbeh.2010.12.019. Sestito RS, Trindade LB, de Souza RG, Kerbauy LN, Iyomasa MM, Rosa ML. Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation. J Psychopharmacol. 2011;25(12):1720-1729. https://doi.org/10.1177/0269881110385595. Toua C, Brand L, Möller M, Emsley RA, Harvey BH. The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-D-aspartate and D1 receptor binding in rats. Neuroscience. 2010;165(2):492-499. https://doi.org/10.1016/j.neuroscience.2009.10.039. Alò R, Avolio E, Mele M, Storino F, Canonaco A, Carelli A et al. Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster. Pharmacol Biochem Behav. 2014; 118:79-86. https://doi.org/10.1016/j.pbb.2014.01.007. St JP, Petkov VV. Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome. General pharmacology. 1990;21(2):223-5. https://doi.org/10.1016/0306-3623(90)90905-2. Miachon S, Rochet T, Mathian B, Barbagli B, Claustrat B. Long-term isolation of Wistar rats alters brain monoamine turnover, blood corticosterone, and ACTH. Brain Res Bull. 1993;32(6):611-614. https://doi.org/10.1016/0361-9230(93)90162-5. Van den Berg CL, Van Ree JM, Spruijt BM, Kitchen I. Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: behavioural and autoradiographic studies. Eur J Neurosci. 1999;11(9):3023-3032. https://doi.org/10.1046/j.1460-9568.1999.00717.x. Vanderschuren LJ, Stein EA, Wiegant VM, Van Ree JM. Social play alters regional brain opioid receptor binding in juvenile rats. Brain Res. 1995;680(1-2):148-156. https://doi.org/10.1016/0006-8993(95)00256-p. Moles A, Kieffer BL, D'Amato FR. Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science. 2004;304(5679):1983-1986. https://doi.org/10.1126/science.1095943. Panksepp J, Herman BH, Vilberg T, Bishop P, DeEskinazi FG. Endogenous opioids and social behavior. Neurosci Biobehav Rev. 1980;4(4):473-487. https://doi.org/10.1016/0149-7634(80)90036-6. Gong JP, Onaivi ES, Ishiguro H, Liu Q, Tagliaferro PA, Brusco A, et al. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res. 2006;1071(1):10-23. https://doi.org/10.1016/j.brainres.2005.11.035. Breivogel CS, Sim-Selley LJ. Basic neuroanatomy and neuropharmacology of cannabinoids. Int Rev Psychiatry 2009; 21:2:113-121. https://doi.org/10.1080/09540260902782760. Haj-Mirzaian A, Amini-Khoei H, Haj-Mirzaian A, Amiri S, Ghesmati M, Zahir M, et al. Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress. Brain Res Bull. 2017; 130:200-210. https://doi.org/10.1016/j.brainresbull.2017.01.018. Banach M, Piskorska B, Czuczwar SJ, Borowicz KK. Nitric Oxide, Epileptic Seizures, and Action of Antiepileptic Drugs. CNS & Neurological Disorders - Drug Targets 2011;10: 808. https://doi.org/10.2174/187152711798072347. Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829-37, 837a-837d. https://dx.doi.org/10.1093%2Feurheartj%2Fehr304. Hu Y, Wu D, Luo C, Zhu L, Zhang J, Wu H, et al. Hippocampal nitric oxide contributes to sex difference in affective behaviors. PNAS. 2012, 109 (35) 14224-14229. https://doi.org/10.1073/pnas.1207461109. Khan MI, Ostadhadi S, Zolfaghari S, Mehr SE, Hassanzadeh G, Dehpour, A et al. The involvement of NMDA receptor/NO/cGMP pathway in the antidepressant like effects of baclofen in mouse force swimming test. Neuroscience Letters. 2016; 612:52-61. https://doi.org/10.1016/j.neulet.2015.12.006. Matsumoto K, Puia G, Dong E, Pinna G. GABAA receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: Possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders. Stress. 2007; 10:1:3-12. https://doi.org/10.1080/10253890701200997. Zlatković J, Filipović D. Chronic social isolation induces NF-κB activation and upregulation of iNOS protein expression in rat prefrontal cortex. Neurochem Int. 2013;63(3):172-179. https://doi.org/10.1016/j.neuint.2013.06.002. Haj-Mirzaian A, Amiri S, Kordjazy N, Momeny M, Razmi A, Balaei MR, et al. Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic-pituitary-adrenal axis function. Neuroscience. 2016; 315:271-285. https://doi.org/10.1016/j.neuroscience.2015.12.024. Larson HJ. The biggest pandemic risk? Viral misinformation. Nature 2018; 562:309. https://doi.org/10.1038/d41586-018-07034-4. Zarocostas J. How to fight an infodemic. Lancet 2020; 395:676. https://doi.org/10.1016/S0140-6736(20)30461-X. World Health Organization, 2019. Ebola Virus Disease – Democratic Republic of the Congo. Geneva, Switzerland: WHO. Available at: https://www.who.int/csr/don/28-november-2019-ebola-drc/en/ [Accessed on August 8, 2020] Times of India. Covid-19: doctors gone to collect samples attacked in Indore. Available at: https://timesofindia.indiatimes.com/videos/news/covid-19-doctors-goneto- collect-samples-attacked-in-indore/videoshow/74942153.cms; 2020 [Accessed on August 8, 2020]. Withnall A. Coronavirus: why India has had to pass new law against attacks on healthcare workers. The Independent. April 23, 2020. Semple K. “Afraid to be a nurse”: health workers under attack. The New York Times. 2020 Apr 27. The Economist. Health workers become unexpected targets during COVID-19. The Economist. May 11, 2020. Turan B, Budhwani H, Fazeli PL, Browning WR, Raper JL, Mugavero MJ, et al. How does stigma affect people living with HIV? The mediating roles of internalized and anticipated HIV stigma in the effects of perceived community stigma on health and psychosocial outcomes. AIDS Behav. 2017; 21: 283–291. https://doi.org/10.1007/s10461-016-1451-5. James PB, Wardle J, Steel A, Adams J. An assessment of Ebola-related stigma and its association with informal healthcare utilisation among Ebola survivors in Sierra Leone: a cross sectional study. BMC Public Health. 2020; 20: 182. https://doi.org/10.1186/s12889-020-8279-7. Aljazeera, 2020. Iran: Over 700 Dead after Drinking Alcohol to Cure Coronavirus. Aljazeera. Available at: https://www.aljazeera.com/ news/2020/04/iran-700-dead-drinking-alcohol-cure-coronavirus200427163529629.html. (Accessed June 4, 2020) Delirrad M, Mohammadi AB, 2020. New methanol poisoning outbreaks in Iran following COVID-19 pandemic. Alcohol Alcohol. 55: 347–348. https://doi.org/10.1093/alcalc/agaa036. Hassanian-Moghaddam H, Zamani N, Kolahi A-A, McDonald R, Hovda KE. Double trouble: methanol outbreak in the wake of the COVID-19 pandemic in Iran-a cross-sectional assessment. Crit Care. 2020; 24: 402. https://doi.org/10.1186/s13054-020-03140-w. Soltaninejad K. Methanol Mass Poisoning Outbreak: A Consequence of COVID-19 Pandemic and Misleading Messages on Social Media. Int J Occup Environ Med. 2020;11(3):148-150. https://dx.doi.org/10.34172%2Fijoem.2020.1983. Islam MS, Sarkar T, Khan SH, Kamal AM, Hasan SMM, Kabir A, et al. COVID-19–Related Infodemic and Its Impact on Public Health: A Global Social Media Analysis. Am J Trop Med Hyg. 2020; 00(0):1–9. https://doi.org/10.4269/ajtmh.20-0812. Hawryluck L, Gold W, Robinson S, Pogorski S, Galea S, Styra R. SARS control and psychological effects of quarantine, Toronto, Canada. Emerg Infect Dis. 2004;10(7):1206–1212. https://dx.doi.org/10.3201%2Feid1007.030703. Lee S, Chan LYY, Chau AAM, Kwok KPS, Kleinman A. The experience of SARS-related stigma at Amoy Gardens. Soc Sci Med. 2005; 61(9): 2038-2046. https://doi.org/10.1016/j.socscimed.2005.04.010. Yoon MK Kim SY Ko HS Lee MS. System effectiveness of detection, brief intervention and refer to treatment for the people with post-traumatic emotional distress by MERS: a case report of community-based proactive intervention in South Korea. Int J Ment Health Syst. 2016; 10: 51. https://doi.org/10.1186/s13033-016-0083-5. Reynolds DL, Garay JR, Deamond SL, Moran MK, Gold W, Styra R. Understanding, compliance and psychological impact of the SARS quarantine experience. Epidemiol Infect. 2008; 136: 997-1007. https://dx.doi.org/10.1017%2FS0950268807009156. Marjanovic Z, Greenglass ER, Coffey S. The relevance of psychosocial variables and working conditions in predicting nurses' coping strategies during the SARS crisis: an online questionnaire survey. Int J Nurs Stud. 2007; 44(6): 991-998. https://doi.org/10.1016/j.ijnurstu.2006.02.012. Bai Y, Lin C-C, Lin C-Y, Chen J-Y, Chue C-M, Chou P. Survey of stress reactions among health care workers involved with the SARS outbreak. Psychiatr Serv. 2004; 55: 1055-1057. https://doi.org/10.1176/appi.ps.55.9.1055. Ministry of Health and Family Welfare. Available at: https://www.mohfw.gov.in/pdf/Guidelinesforhomequarantine.pdf [Accessed on 25 August 2020]. Ministry of Health and Family Welfare. Available at: https://www.mohfw.gov.in/pdf/RevisedguidelinesforHomeIsolationofverymildpresymptomaticCOVID19cases10May2020.pdf [Accessed on 25 August 2020]. Ministry of Health and Family Welfare. Available at: https://www.mohfw.gov.in/pdf/AdvisoryformanagingHealthcareworkersworkinginCOVIDandNonCOVIDareasofthehospital.pdf (Accessed on 25 August 2020). Ministry of Health and Family Welfare. Available at: https://www.mohfw.gov.in/pdf/RevisedguidelinesforInternationalArrivals02082020.pdf [Accessed on 25 August 2020]. Cost of the lockdown? Over 10% of GDP loss for 18 states. Available at: https://timesofindia.indiatimes.com/india/cost-of-the-lockdown-over-10-of-gdp-loss-for-18-states/articleshow/76028826.cms [Accessed on 21 August 2020]. Jorda O, Singh SR, Taylor AM. Longer-Run Economic Consequences of Pandemics. Federal Reserve Bank of San Francisco Working Paper. 2020-09. https://doi.org/10.24148/wp2020-09. Firdaus G. Mental well‑being of migrants in urban center of India: Analyzing the role of social environment. Indian J Psychiatry. 2017; 59:164‑ https://doi.org/10.4103/psychiatry.indianjpsychiatry_272_15. National Crime Record Bureau. Annual Crime in India Report. New Delhi, India: Ministry of Home Affairs; 2018. 198 migrant workers killed in road accidents during lockdown: Report. Available at: https://www.hindustantimes.com/india-news/198-migrant-workers-killed-in-road-accidents-during-lockdown-report/story-hTWzAWMYn0kyycKw1dyKqL.html [Accessed on 25 August 2020]. Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020; 20:689-96. https://doi.org/10.1016/S1473-3099(20)30198-5. Dalton L, Rapa E, Stein A. Protecting the psychological health of through effective communication about COVID-19. Lancet Child Adolesc Health. 2020;4(5):346-347. https://doi.org/10.1016/S2352-4642(20)30097-3. Centre for Disease Control. Helping Children Cope with Emergencies. Available at: https://www.cdc.gov/childrenindisasters/helping-children-cope.html [Accessed on 25 August 2020]. Liu JJ, Bao Y, Huang X, Shi J, Lu L. Mental health considerations for children quarantined because of COVID-19. Lancet Child & Adolesc Health. 2020; 4(5):347-349. https://doi.org/10.1016/S2352-4642(20)30096-1. Sprang G, Silman M. Posttraumatic Stress Disorder in Parents and Youth After Health-Related Disasters. Disaster Med Public Health Prep. 2013;7(1):105-110. https://doi.org/10.1017/dmp.2013.22. Rehman U, Shahnawaz MG, Khan NH, Kharshiing KD, Khursheed M, Gupta K, et al. Depression, Anxiety and Stress Among Indians in Times of Covid-19 Lockdown. Community Ment Health J. 2020:1-7. https://doi.org/10.1007/s10597-020-00664-x. Cao W, Fang Z, Hou, Han M, Xu X, Dong J, et al. The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Research. 2020; 287:112934. https://doi.org/10.1016/j.psychres.2020.112934. Wang C, Zhao H. The Impact of COVID-19 on Anxiety in Chinese University Students. Front Psychol. 2020; 11:1168. https://dx.doi.org/10.3389%2Ffpsyg.2020.01168. Kang L, Li Y, Hu S, Chen M, Yang C, Yang BX, et al. The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus. Lancet Psychiatry 2020;7(3): e14. https://doi.org/10.1016/s2215-0366(20)30047-x. Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, et al. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020;3(3): e203976. https://doi.org/10.1001/jamanetworkopen.2020.3976. Lancee WJ, Maunder RG, Goldbloom DS, Coauthors for the Impact of SARS Study. Prevalence of psychiatric disorders among Toronto hospital workers one to two years after the SARS outbreak. Psychiatr Serv. 2008;59(1):91-95. https://dx.doi.org/10.1176%2Fps.2008.59.1.91. Tam CWC, Pang EPF, Lam LCW, Chiu HFK. Severe acute respiratory syndrome (SARS) in Hongkong in 2003: Stress and psychological impact among frontline healthcare workers. Psychol Med. 2004;34 (7):1197-1204. https://doi.org/10.1017/s0033291704002247. Lee SM, Kang WS, Cho A-R, Kim T, Park JK. Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients. Compr Psychiatry. 2018; 87:123-127. https://dx.doi.org/10.1016%2Fj.comppsych.2018.10.003. Koh D, Meng KL, Chia SE, Ko SM, Qian F, Ng V, et al. Risk perception and impact of severe acute respiratory syndrome (SARS) on work and personal lives of healthcare workers in Singapore: What can we learn? Med Care. 2005;43(7):676-682. https://doi.org/10.1097/01.mlr.0000167181.36730.cc. Verma S, Mythily S, Chan YH, Deslypere JP, Teo EK, Chong SA. Post-SARS psychological morbidity and stigma among general practitioners and traditional Chinese medicine practitioners in Singapore. Ann Acad Med Singap. 2004; 33(6):743e8. Yeung J, Gupta S. Doctors evicted from their homes in India as fear spreads amid coronavirus lockdown. CNN World. 2020. Available at: https://edition.cnn.com/2020/03/25/asia/india-coronavirus-doctors-discrimination-intl-hnk/index.html. [Accessed on 24 August 2020] Violence Against Women and Girls: the Shadow Pandemic. UN Women. 2020. May 3, 2020. Available at: https://www.unwomen.org/en/news/stories/2020/4/statement-ed-phumzile-violence-against-women-during-pandemic. [Accessed on 24 August 2020]. Gearhart S, Patron MP, Hammond TA, Goldberg DW, Klein A, Horney JA. The impact of natural disasters on domestic violence: an analysis of reports of simple assault in Florida (1999–2007). Violence Gend. 2018;5(2):87–92. https://doi.org/10.1089/vio.2017.0077. Sahoo S, Rani S, Parveen S, Pal Singh A, Mehra A, Chakrabarti S, et al. Self-harm and COVID-19 pandemic: An emerging concern – A report of 2 cases from India. Asian J Psychiatr 2020; 51:102104. https://dx.doi.org/10.1016%2Fj.ajp.2020.102104. Ghosh A, Khitiz MT, Pandiyan S, Roub F, Grover S. Multiple suicide attempts in an individual with opioid dependence: Unintended harm of lockdown during the COVID-19 outbreak? Indian J Psychiatry 2020; [In Press]. The Economic Times. 11 Coronavirus suspects flee from a hospital in Maharashtra. March 16 2020. Available at: https://economictimes.indiatimes.com/news/politics-and-nation/11-coronavirus-suspects-flee-from-a-hospital-in-maharashtra/videoshow/74644936.cms?from=mdr. [Accessed on 23 August 2020]. Xiang Y, Yang Y, Li W, Zhang L, Zhang Q, Cheung T, et al. Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed. The Lancet Psychiatry 2020;(3):228–229. https://doi.org/10.1016/S2215-0366(20)30046-8. Van Bortel T, Basnayake A, Wurie F, Jambai M, Koroma A, Muana A, et al. Psychosocial effects of an Ebola outbreak at individual, community and international levels. Bull World Health Organ. 2016;94(3):210–214. https://dx.doi.org/10.2471%2FBLT.15.158543. Kumar A, Nayar KR. COVID 19 and its mental health consequences. Journal of Mental Health. 2020; ahead of print:1-2. https://doi.org/10.1080/09638237.2020.1757052. Gupta R, Grover S, Basu A, Krishnan V, Tripathi A, Subramanyam A, et al. Changes in sleep pattern and sleep quality during COVID-19 lockdown. Indian J Psychiatry. 2020; 62(4):370-8. https://doi.org/10.4103/psychiatry.indianjpsychiatry_523_20. Duan L, Zhu G. Psychological interventions for people affected by the COVID-19 epidemic. Lancet Psychiatry. 2020;7(4): P300-302. https://doi.org/10.1016/S2215-0366(20)30073-0. Dubey S, Biswas P, Ghosh R, Chatterjee S, Dubey MJ, Chatterjee S et al. Psychosocial impact of COVID-19. Diabetes Metab Syndr. 2020; 14(5): 779–788. https://dx.doi.org/10.1016%2Fj.dsx.2020.05.035. Wright R. The world's largest coronavirus lockdown is having a dramatic impact on pollution in India. CNN World; 2020. Available at: https://edition.cnn.com/2020/03/31/asia/coronavirus-lockdown-impact-pollution-india-intl-hnk/index.html. [Accessed on 23 August 2020] Foster O. ‘Lockdown made me Realise What’s Important’: Meet the Families Reconnecting Remotely. The Guardian; 2020. Available at: https://www.theguardian.com/keep-connected/2020/apr/23/lockdown-made-me-realise-whats-important-meet-the-families-reconnecting-remotely. (Accessed on 23 August 2020) Bilefsky D, Yeginsu C. Of ‘Covidivorces’ and ‘Coronababies’: Life During a Lockdown. N. Y. Times; 2020. Available at: https://www.nytimes.com/2020/03/27/world/coronavirus-lockdown-relationships.html [Accessed on 23 August 2020]

Thalassemia là bệnh lý di truyền gây thiếu máu tan máu. Truyền máu thường xuyên thường liên quan đến tình trạng quá tải sắt ở các cơ quan. Để điều trị tình trạng thừa sắt đòi hỏi phải đánh giá chính xác tình trạng ứ sắt của cơ quan. Mục tiêu: đánh giá tình trạng quá tải sắt và mối tương quan giữa ferritin huyết thanh, nồng độ sắt trong gan (LIC- liver iron concentration) và T2* tim dựa trên cộng hưởng từ (MRI) của bệnh nhân thalassemia tại bệnh viện Nhi Trung ương năm 2018-2020. Đối tượng, phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, từ 8/2018- 8/2020, chúng tôi thu thập được 79 bệnh nhân nhi thalassemia truyền máu định kỳ tại bệnh viện Nhi Trung ương. Tiến hành đánh giá đặc điểm lâm sàng, xét nghiệm và chụp MRI đánh giá tình trạng ứ sắt ở gan (LIC) và tim (T2*). Kết quả nghiên cứu: Ferritin huyết thanh trung bình (3298.6 ± 3055,2 ng/ml) và LIC trung bình (12.90 ± 5,6 mg/g) đều ở mức trung bình nặng, T2* tim trung bình là 29 ±11,7 ms. Ferritin huyết thanh có mối tương quan yếu với LIC và T2* tim (tương ứng với r= 0,441 và -0,32), LIC và T2*tim không có mối tương quan. Kết luận: Tình trạng quá tải sắt ở gan ở mức cao, nhưng không tương quan với tình trạng quá tải sắt ở tim. Ferritin có mối tương quan yếu với LIC và T2* tim.

06–194Altarriba, Jeanette & Jennifer L. Gianico (U Albany, State U New York, USA), Lexical ambiguity resolution across languages: A theoretical and empirical review. Experimental Psychology (Hogrefe & Huber Publishers) 50.3 (2003), 159–170.06–195Bialystok, Ellen (York U, Canada; ellenb@yorku.ca) & Dana Shapero, Ambiguous benefits: The effect of bilingualism on reversing ambiguous figures. Developmental Science (Blackwell) 8.6 (2005), 595.06–196Blot, J. Kevin (Clark U & Boston College, USA), Michael A. Zaraté & Paul B. Paulus, Code-switching across brainstorming sessions: Implications for the revised hierarchical model of bilingual language processing. Experimental Psychology (Hogrefe & Huber Publishers) 50.3 (2003), 171–183.06–197Costa, Albert (U Barcelona, Spain; acosta@ub.edu), Mikel Santesteban & Agnès Caño, On the facilitatory effects of cognate words in bilingual speech production. Brain and Language (Elsevier) 94.1 (2005), 94–103.06–198De Diego Balaguer, R. (Faculté de Médecine, Paris XII, France), N. Sebastián-Gallés, B. Díaz & A. Rodríguez-Fornells, Morphological processing in early bilinguals: An ERP study of regular and irregular verb processing. Cognitive Brain Research (Elsevier) 25.1 (2005), 312–327.06–199Elston-Güttler, Kerrie E. (Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig, Germany; km.guettler@t.online.de) & Angela D. Friederici, Native and L2 processing of homonyms in sentential context. Journal of Memory and Language (Elsevier) 52.2 (2005), 256–283.06–200Luka, Barbara J. (Bard College, USA; Luka@bard.edu) & Lawrence W. Barsalou, Structural facilitation: Mere exposure effects for grammatical acceptability as evidence for syntactic priming in comprehension. Journal of Memory and Language (Elsevier) 52.3 (2005), 436–459.06–201McLaughlin, Judith (U Washington, USA; giuditta@u.washington.edu), Lee Osterhout & Albert Kim, Neural correlates of second- language word learning: Minimal instruction produces rapid change. Nature Neuroscience (Nature Publishing Group) 7 (2004), 703–704.06–202Mechelli, Andrea (Wellcome Department of Imaging Neuroscience, U London, UK; a.mechelli@fil.ion.ucl.ac.uk), Jenny T. Crinion, Uta Noppeney, John O'Doherty, John Ashburner, Richard S. Frackowiak & Cathy J. Price, Neurolinguistics: Structural plasticity in the bilingual brain. Nature (Nature Publishing Group) 431.757 (2004), 256–283.06–203Meijer, Paul J. A. (Clark U & Boston College, USA) & Jean E. Fox Tree, Building syntactic structures in speaking: A bilingual exploration. Experimental Psychology (Hogrefe & Huber Publishers) 50.3 (2003), 184–195.06–204Moreno, Eva M. (U Califonia, USA; kutas@cogsci.ucsd.edu) & Marta Kutas, Processing semantic anomalies in two languages: An electrophysiological exploration in both languages of Spanish–English bilinguals. Cognitive Brain Research (Elsevier) 22.2 (2005), 205–220.06–205Pallier, C. (Service Hospitalier Fredrik Joliot, Orsay, France; pallier@lscp.ehess.fr), S. Dehaene, J.-B. Poline, D. Lebihan, A.-M. Argenti, E. Dupoux & J. Mehler, Brain imaging of language plasticity in adopted adults: Can a second language replace the first?Cerebral Cortex (Oxford University Press) 13.2 (2003), 155–161.06–206Reiterer, Susanne (U Vienna, Austria; Susanne.Reiterer@med.uni-tuebingen.de), Claudia Hemmelmann, Peter Rappelsberger & Michael L. Berger, Characteristic functional networks in high- versus low-proficiency second-language speakers detected also during native language processing: An explorative EEG coherence study in 6 frequency bands. Cognitive Brain Research (Elsevier) 25.2 (2005), 566–578.06–207Tham, Wendy W. P. (Nanyang Technological U, Singapore), Susan J. Rickard Liow, Jagath C. Rajapakse, Tan Choong Leong, Samuel E. S. Ng, Winston E. H. Lim & Lynn G. Homoreno, Phonological processing in Chinese–English bilingual biscriptals: An fMRI study. Neuroimage (Elsevier) 28.3 (2005), 579–587.

Concentrations of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in settled house dust and road dust samples collected from a core urban area of Hanoi. Levels of PAHs ranged from 830 to 3500 (median 2000) ng/g in house dust, and from 1400 to 4700 (median 1700) ng/g in road dust. Concentrations of PAHs in dust samples of this study were within the moderate range as compared with those from other countries in the world. Toxic equivalents to benzo[a]pyrene (BaP-EQs) in our samples ranged from 81 to 850 (median 330) ng BaP-EQ/g with principal contributors as BaP and dibenz[a,h]anthracene, which accounted for 69% to 93% of BaP-EQs. In almost all the samples, proportions of high-molecular-weight PAHs (HMW-PAHs with 4–6 rings) were higher than those of low-molecular-weight PAHs (LMW-PAHs with 2–3 rings), suggesting emission sources from combustion processes rather than direct contamination by petrogenic sources. Traffic activities were estimated as important sources of PAHs in the studied areas, for example, vehicular exhaust and tire debris. Keywords: PAHs, house dust, road dust, traffic emission, urbanization. References [1] K. Srogi, Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: a review, Environ. Chem. Let. 5 (2007) 169-195. https://doi. org/10.1007/s10311-007-0095-0.[2] K.H. Kim, S.A. Jahan, E. Kabir, R.J.C. Brown, A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. Environ. Int. 60 (2013) 71–80. https://doi. org/10.1016/j.envint.2013.07.019.[3] E. Stogiannidis, R. Laane, Source characterization of polycyclic aromatic hydrocarbons by using their molecular indices: an overview of possibilities. Rev. Environ. Contam. Toxicol. 234 (2015) 49–133. https://doi.org/10.1007/978-3-319-10638-0_2.[4] H.I. Abdel-Shafy, M.S.M. Mansour, A review on polycyclic aromatic hydrocarbons: source, environmental impacts, effect on human health and remediation. Egypt. J. Pet. 25 (2016) 107–123. https://doi.org/10.1016/j.ejpe.2015.03.011.[5] ATSDR, 1995. Toxicological profile for polycyclic aromatic hydrocarbons. https://www.atsdr.cdc. gov/toxprofiles/tp69.pdf.[6] M.T. Anh, L.M. Triet, J.J. Sauvain, J. Tarradellas, PAH contamination levels in air particles and sediments of Ho Chi Minh City, Vietnam. Bull. Environ. Contam. Toxicol. 63 (1999) 728–735. https://doi.org/10.1007/s00128 9901040.[7] T.T. Hien, L.T. Thanh, T. Kameda, N. Takenaka, H. Bandow, Distribution characteristics of polycyclic aromatic hydrocarbons with particle size in urban aerosols at the roadside in Ho Chi Minh City, Vietnam. Atmos. Environ. 41 (2007) 1575–1586. https://doi.org/10.1016/j.atmosenv. 2006.10.045.[8] M. Kishida, K. Imamura, N. Takenaka, Y. Maeda, P.H. Viet, H. Bandow, Concentrations of atmospheric polycyclic aromatic hydrocarbons in particulate matter and the gaseous phase at roadside sites in Hanoi, Vietnam. Bull. Environ. Contam. Toxicol. 81 (2008) 174–179. https://doi. org/10.1007/s00128-008-9450-5. [9] H.Q. Anh, K. Tomioka, N.M. Tue, L.H. Tuyen, N.K. Chi, T.B. Minh, P.H. Viet, S. Takahashi, A preliminary investigation of 942 organic micro-pollutants in the atmosphere in waste processing and urban areas, northern Vietnam: levels, potential sources, and risk assessment. Ecotoxicol. Environ. Saf. 167 (2019) 354–364. https://doi.org/10.1016/j.ecoenv.2018.10.026.[10] C.V. Hung, B.D. Cam, P.T.N Mai, B.Q. Dzung, Heavy metals and polycyclic aromatic hydrocarbons in municipal sewage sludge from a river in highly urbanized metropolitan area in Hanoi, Vietnam: levels, accumulation pattern and assessment of land application. Environ. Geochem. Health 37 (2015) 133–146. https:// doi.org/10.1007/s10653-014-9635-2.[11] C.T. Pham, N. Tang, A. Toriba, K. Hayakawa, Polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in atmospheric particles and soil at a traffic site in Hanoi, Vietnam. Polycycl. Aromat. Comp. 35 (2015) 355–371. https://doi.org/10.1080/10406 638.2014.903284.[12] H.Q. Anh, K. Tomioka, N.M. Tue, G. Suzuki, T.B. Minh, P.H. Viet, S. Takahashi, Comprehensive analysis of 942 organic micro-pollutants in settled dusts from northern Vietnam: pollution status and implications for human exposure. J. Mater. Cycles Waste Manag. 21 (2019) 57–66. https://doi.org/10.1007/s101 63-018-0745-2.[13] L.H. Tuyen, N.M. Tue, G. Suzuki, K. Misaki, P.H. Viet, S. Takahashi, S. Tanabe, Aryl hydrocarbon receptor mediated activities in road dust from a metropolitan area, Hanoi-Vietnam: contribution of polycyclic aromatic hydrocarbons (PAHs) and human risk assessment. Sci. Total Environ. 491-492 (2014) 246–254. https://doi.org/10.1016/j.scitotenv.2014. 01.086.[14] L.H. Tuyen, N.M. Tue, S. Takahashi, G. Suzuki, P.H. Viet, A. Subramanian, K.A. Bulbule, P. Parthasarathy, A. Ramanathan, S. Tanabe, Methylated and unsubstituted polycyclic aromatic hydrocarbons in street dust from Vietnam and India: occurrence, distribution and in vitro toxicity evaluation. Environ. Pollut. 194 (2014) 272–280. https://doi.org/10.1016/j.envpol. 2014.07.029.[15] H.Q. Anh, T.M. Tran, N.T.T. Thuy, T.B. Minh, S. Takahashi, Screening analysis of organic micro-pollutants in road dusts from some areas in northern Vietnam: a preliminary investigation on contamination status, potential sources, human exposures, and ecological risk. Chemosphere 224 (2019) 428–436. https://doi.org/10.1016/j. chemosphere.2019.02.177.[16] H.T.T. Thuy, T.T.C. Loan, T.H. Phuong, The potential accumulation of polycyclic aromatic hydrocarbons in phytoplankton and bivalves in Can Gio coastal wetland, Vietnam. Environ. Sci. Pollut. Res. 25 (2018) 17240–17249. https://doi. org/10.1007/s11356-018-2249-y.[17] P.C. Van Metre, B.J. Mahler, J.T. Wilson, PAHs underfoot: contaminated dust from coal-tar sealcoated pavement is widespread in the United States. Environ. Sci. Technol. 43 (2009) 20–25. https://doi.org/10.1021/es802119h.[18] L. Liu, A. Liu, Y. Li, L. Zhang, G. Zhang, Y. Guan, Polycyclic aromatic hydrocarbons associated with road deposited solid and their ecological risk: Implications for road stormwater reuse. Sci. Total Environ. 563–564 (2016) 190–198. https://doi.org/10.1016/j.scitotenv.2016.04.114.[19] X. Zheng, Y. Yang, M. Liu, Y. Yu, J.L. Zhou, D. Li, PAH determination based on a rapid and novel gas purge-microsyringe extraction (GP-MSE) technique in road dust of Shanghai, China: Characterization, source apportionment, and health risk assessment. Sci. Total Environ. 557–558 (2016) 688–696. https://doi.org/10.1016/j. scitotenv.2016.03.124.[20] T.T. Dong, B.K. Lee, Characteristics, toxicity, and source apportionment of polycyclic aromatic hydrocarbons (PAHs) in road dust of Ulsan, Korea. Chemosphere 74 (2009) 1245–1253. https: //doi.org/10.1016/j.chemosphere.2008.11.035.[21] R. Khanal, H. Furumai, F. Nakajima, C. Yoshimura, Carcinogenic profile, toxicity and source apportionment of polycyclic aromatic hydrocarbons accumulated from urban road dust in Tokyo, Japan. Ecotoxicol. Environ. Saf. 165 (2018) 440–449. https://doi.org/10.1016/j. ecoenv.2018.08.095.[22] N. Soltani, B. Keshavarzi, F. Moore, T. Tavakol, A.R. Lahijanzadeh, N. Jaafarzadeh, M. Kermani, Ecological and human health hazards of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in road dust of Isfahan metropolis, Iran. Sci. Total Environ. 505 (2015) 712–723. https://doi.org/10.1016/j.scitotenv.2014.09.097.[23] B.A.M. Bandowe, M.A. Nkansah, Occurrence, distribution and health risk from polycyclic aromatic compounds (PAHs, oxygenated-PAHs and azaarenes) in street dust from a major West African Metropolis. Sci. Total Environ. 553 (2016) 439-449. https://doi.org/10.1016/j. scitotenv.2016.02.142.[24] T.C. Nguyen, P. Loganathan, T.V. Nguyen, S. Vigneswaran, J. Kandasamy, D. Slee, G. Stevenson, R. Naidu, Polycyclic aromatic hydrocarbons in road-deposited sediments, water sediments, and soils in Sydney, Australia: Comparisons of concentration distribution, sources and potential toxicity. Ecotoxicol. Environ. Saf. 104 (2014) 339–348. https://doi.org/10.1016/j.ecoenv.2014.03.010. [25] C. Y. Kuo, H.C. Chen, F.C. Cheng, L.R. Huang, P.S. Chien, J.Y. Wang, Polycyclic aromatic hydrocarbons in household dust near diesel transport routes. Environ. Geochem. Health 34 (2012) 77–87. https://doi.org/10.1007/s10653-011-9392-4.[26] W. Wang, F.Y. Wu, J.S. Zheng, M.H. Wong, Risk assessments of PAHs and Hg exposure via settled house dust and street dust, linking with their correlations in human hair. J. Hazard. Mater. 263 (2013) 627–637. https://doi.org/10.1016/j.jhazmat. 2013.10.023.[27] N. Ali, I.M.I. Ismail, M. Khoder, M. Shamy, M. Alghamdi, M. Costa, L.N. Ali, W. Wang, S.A.M.A.S. Eqani, Polycyclic aromatic hydrocarbons (PAHs) in indoor dust samples from cities of Jeddah and Kuwait: levels, sources and non-dietary human exposure. Sci. Total Environ. 573 (2016) 1607–1614. https://doi.org/10.1016/j. scitotenv.2016.09.134.[28] M.Y. Civan, U.M. Kara, Risk assessment of PBDEs and PAHs in house dust in Kocaeli, Turkey: levels and sources. Environ. Sci. Pollut. Res. 23 (2016) 23369–23384. https://doi.org/10. 1007/s11356-016-7512-5.[29] A. Maragkidou, S. Arar, A. Al-Hunaiti, Y. Ma, S. Harrad, O. Jaghbeir, D. Faouri, K. Hämeri, T. Hussein, Occupational health risk assessment and exposure to floor dust PAHs inside an educational building. Sci. Total Environ. 579 (2017) 1050–1056. https://doi.org/10.1016/j.scitotenv.2016. 11.055. [30] I.C. Yadav, N.L. Devi, J. Li, G. Zhang, Polycyclic aromatic hydrocarbons in house dust and surface soil in major urban regions of Nepal: implication on source apportionment and toxicological effect. Sci. Total Environ. 616–617 (2018) 223–235. https://doi.org/10.1016/j.scitotenv.2017.10.313.[31] R. Boonyatumanond, M. Murakami, G. Wattayakorn, A. Togo, H. Takada, Sources of polycyclic aromatic hydrocarbons (PAHs) in street dust in a tropical Asian mega-city, Bangkok, Thailand. Sci. Total Environ. 384 (2007) 420−432. https://doi.org/10.1016/j.scitotenv. 2007.06.046.[32] I. Sadiktsis, C. Bergvall, C. Johansson, R. Westerholm, Automobile tire–a potential source of highly carcinogenic dibenzopyrenes to the environment. Environ. Sci. Technol. 46 (2012) 3326−3334. https://doi.org/10.1021/es204257d.[33] M. Howsam, K.C. Jones, Sources of PAHs in the environment. In: Neilson, A.H. (Ed.), The Handbook of Environmental Chemistry Vol. 3 Part I PAHs and Related Compounds. Springer-Verlag, Berlin, Heidelberg (1998) 137–174. https://doi.org/10.1007/978-3-540-49697-7_4.[34] I.C.T. Nisbet, P.K. Lagoy, Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regul. Toxicol. Pharmacol. 16 (1992) 290–300. https://doi.org/10. 1016/0273-2300(92)90009-X.[35] B. Pieterse, E. Felzel, R. Winter, B. van der Burg, A. Brouwer, PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Environ. Sci. Technol 47 (2013) 11651–11659. https://doi.org/10.1021/es403810w.[36] M.B. Yunker, R.W. Macdonald, R. Vingarzan, R. H. Mitchell, D. Goyette, S. Sylvestre, PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition. Org. Geochem. 33 (2002) 489–515. https://doi.org/10.1016/S0146-6380(02)00002-5.[37] M. Saha, A. Togo, K. Mizukawa, M. Murakami, H. Takada, M.P. Zakaria, N.H. Chiem, B.C. Tuyen, M. Prudente, R. Boonyatumanond, S.K. Sarkar, B. Bhattacharya, P. Mishra, T.S. Tana, Sources of sedimentary PAHs in tropical Asian waters: differentiation between pyrogenic and petrogenic sources by alkyl homolog abundance. Mar. Pollut. Bull. 58 (2009) 189–200. https://doi.org/10.1016/j.marpolbul.2008.04.049.

Malaysian contemporary music, an emerging and highly diverse art form, has gained recognition both in Malaysia and internationally over the last decade. Nevertheless, few studies have been completed and most conclude that there is no common compositional trend. This study, however, highlights that one common trend has emerged since 2000, namely, Malaysian composers have increasingly assimilated cultural elements into their compositions. The resulting works have been metaphorically compared to the national salad dish, rojak, in which all constituent parts are readily identifiable even when mixed together. It is argued that the assimilation of cultures is central to an understanding of Malaysian contemporary music, even though it is not the only compositional approach. Twenty-nine works by five selected Malaysian composers are analysed in this study. The composers are: Kee Yong Chong (b.1971), Chong Lim Ng (b.1972), Tazul Izan Tajuddin (b.1969), Johan Awang Othman (b.1969), and Kah Hoe Yii (b.1970). Musical score analysis, combined with the interpretation of data collected through fieldwork trips to Malaysia and Singapore, reveal the ways these composers have assimilated a myriad of cultural elements, including gamelan, Malay poem pantun, mak yong [Malaysian ancient theatre], wayang kulit [shadow puppet play], Balinese baris dance, the concept of tenunan [weave] and batik, Chinese calligraphy and painting, Chinese orchestra and its instruments, Chinese philosophy, and Islamic, Buddhist and Christian spiritual practices, into their compositions. This study concludes that their use of idiosyncratic approaches is becoming increasingly distinctive to Malaysian compositions and a reflection of the same processes of mixing identifiable ingredients that is found in the national rojak salads.
Thesis (Ph.D.) -- University of Adelaide, Elder Conservatorium of Music, 2018