Relevant bibliographies by topics / Chloroquine

Academic literature on the topic 'Chloroquine'

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Published: 4 June 2021
Last updated: 27 January 2023

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Journal articles on the topic "Chloroquine"

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Zdun, Sylwia, Klaudia Walczak, Weronika Gaweł, Zuzanna Wesołowska, Przemysław Jędruszczak, Natalia Grzywna, Sylwia Nemeczek, Konrad Merkisz, Jakub Grzybowski, and Patrycja Walczak. "Side effects of long-term treatment with chloroquine for rheumatoid arthritis - a review of the literature." Journal of Education, Health and Sport 13, no. 2 (December 28, 2022): 165–71. http://dx.doi.org/10.12775/jehs.2023.13.02.023.

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Background: Chloroquine is a 4-aminoquinoline derivative. Initially the substance was used as an antimalarial drug, but now chloroquine is also used to treat connective tissue diseases. It is a widely used drug in rheumatological diseases, especially in rheumatoid arthritis and systemic lupus erythematosus. A number of side effects have been reported in the public literature among patients using this drug. This article reviews side effects during long-term treatment of patients with rheumatoid arthritis. Materials and methods: A review of the literature available in the PubMed database was performed, using the key words: "Chloroquin" ; "Chloroquin rheumatoid" ; "Chloroquin toxicity" ; "Chloroquine" ; "Chloroquine rheumatoid" ; "Chloroquine toxicity". Results: Chloroquine is a quinine derivative, originally used in the prevention and treatment of malaria. It is now being successfully used to treat patients with certain connective tissue diseases, including rheumatoid arthritis. A number of publications have described various side effects of this drug. Serious and major problems arise from the drug's toxicity with long-term use, such as in the treatment of rheumatoid arthritis. Long-term use of the drug results in retinopathy and cardiotoxicity (conduction disturbances, cardiomyopathy). The available literature also mentions neuromyotoxicity which is rarely reported by patients. Conclusion: Long-term use of chloroquine carries serious side effects. The main complications of long-term use of the drug affect the visual, cardiovascular and nervous systems. The use of chloroquine in patients with rheumatoid arthritis should emphasize the need for accurate dosing and periodic cardiovascular, ophthalmologic and neurologic monitoring.
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Blackard, W. G., R. M. Smith, and L. Jarett. "Insulin processing by cultured hepatocytes." American Journal of Physiology-Endocrinology and Metabolism 250, no. 2 (February 1, 1986): E148—E155. http://dx.doi.org/10.1152/ajpendo.1986.250.2.e148.

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The chloroquine-sensitive and chloroquine-insensitive steps in insulin degradation by cultured hepatocytes have been explored by employing low temperature to retard processing. Under standard conditions (90 min association and 60 min dissociation) chloroquine inhibited insulin degradation at 15 degrees C but not at 37 degrees C. However, if the association and dissociation periods were short so that only early degradation was examined, marked inhibition of insulin degradation by chloroquine could also be observed at 37 degrees C. This inhibitory effect was observed only during the first 15 min, being masked by increased insulin degradation subsequently. An increase in slowly dissociable insulin, as well as a twofold increase in volume density of multivesicular bodies (MVB), occurred in the presence of chloroquine at both 37 and 15 degrees C. Rapid insulin processing from the slowly dissociable compartment at 37 degrees C masked chloroquine's effect on insulin processing under usual conditions at that temperature. At physiological temperature the chloroquine-sensitive step is not obligatory for insulin degradation by hepatocytes.
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Ridley, R. G., W. Hofheinz, H. Matile, C. Jaquet, A. Dorn, R. Masciadri, S. Jolidon, et al. "4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum." Antimicrobial Agents and Chemotherapy 40, no. 8 (August 1996): 1846–54. http://dx.doi.org/10.1128/aac.40.8.1846.

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We have synthesized several 4-aminoquinolines with shortened side chains that retain activity against chloroquine-resistant isolates of Plasmodium falciparum malaria (W. Hofheinz, C. Jaquet, and S. Jolidon, European patent 94116281.0, June 1995). We report here an assessment of the activities of four selected compounds containing ethyl, propyl, and isopropyl side chains. Reasonable in vitro activity (50% inhibitory concentration, < 100 nM) against chloroquine-resistant P. falciparum strains was consistently observed, and the compounds performed well in a variety of plasmodium berghei animal models. However, some potential drawbacks of these compounds became evident upon in-depth testing. In vitro analysis of more than 70 isolates of P. falciparum and studies with a mouse in vivo model suggested a degree of cross-resistance with chloroquine. In addition, pharmacokinetic analysis demonstrated the formation of N-dealkylated metabolites of these compounds. These metabolites are similarly active against chloroquine-susceptible strains but are much less active against chloroquine-resistant strains. Thus, the clinical dosing required for these compounds would probably be greater for chloroquine-resistant strains than for chloroquine-susceptible strains. The clinical potential of these compounds is discussed within the context of chloroquine's low therapeutic ratio and toxicity.
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&NA;. "Chloroquine see Proguanil/chloroquine." Reactions Weekly &NA;, no. 287 (February 1990): 6. http://dx.doi.org/10.2165/00128415-199002870-00013.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 1391 (March 2012): 16. http://dx.doi.org/10.2165/00128415-201213910-00057.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 696 (April 1998): 6. http://dx.doi.org/10.2165/00128415-199806960-00015.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 711 (July 1998): 7. http://dx.doi.org/10.2165/00128415-199807110-00020.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 726 (November 1998): 7. http://dx.doi.org/10.2165/00128415-199807260-00020.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 729 (November 1998): 7. http://dx.doi.org/10.2165/00128415-199807290-00020.

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&NA;. "Chloroquine." Reactions Weekly &NA;, no. 741 (March 1999): 7. http://dx.doi.org/10.2165/00128415-199907410-00021.

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Dissertations / Theses on the topic "Chloroquine"

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Mahon, Gerald J. "Studies on chloroquine retinopathy." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388235.

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LAGARDE, CLAIRE. "Intoxication aigue par la chloroquine." Lille 2, 1997. http://www.theses.fr/1997LIL2P052.

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Eliot, Marc. "La chloroquine : aspect toxicologique actuel." Lyon 1, 1990. http://www.theses.fr/1990LYO1M243.

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Caliez, Catherine. "Contribution au dosage immunochimique de la chloroquine dans les milieux biologiques." Paris 5, 1988. http://www.theses.fr/1988PA05P608.

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Kendrick, Kelsie Lynn. "Mimicking Metabolism of a Reversed Chloroquine Antimalarial." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/2085.

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The aim of this study was to elucidate the oxidation products of a candidate antimalarial drug, PL69, using a porphyrin system and to determine the accuracy of the oxidation products produced, as compared to what is expected in metabolism. PL69 is a reversed chloroquine (RCQ) that is active against chloroquine resistant malaria. Porphyrin oxidation systems have been shown to mimic in vitro enzymatic metabolism reactions. PL69 and its known metabolite, PL16, were incubated with the porphyrin system, and then the oxidation products were collected and separated by HPLC. The oxidation products were characterized by NMR and mass spectrometry and compared to previous metabolism studies of PL69 with liver microsomes. The results of this research show that this porphyrin system is an acceptable mimic of in vitro metabolism methods for RCQs and provides a good framework for understanding the types of metabolism that will occur in vivo for RCQs.
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Onde, Olivier. "Actualités en réanimation pré-hospitalière et hospitalière immédiate des intoxications aigues par la chloroquine." Montpellier 1, 1989. http://www.theses.fr/1989MON11325.

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Jehl, Patrick. "Mécanismes de la chloroquinorésistance chez "Plasmodium falciparum" : intérêt de l'étude de la multirésistance des cellules cancéreuses." Paris 5, 1989. http://www.theses.fr/1989PA05P070.

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Ng, Anna. "Taste-masked and controlled-release formulations of chloroquine." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267929.

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Saliba, Kevin John. "Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles." Doctoral thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26631.

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Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and intact Plasmodium falciparum isolated digestive vacuoles, the site of chloroquine accumulation and action. Marker enzymes and gel electrophoresis were used to demonstrate purity, and electron microscopy to verify integrity of isolated vacuoles. Using this method, vacuoles were isolated in a yield high enough to enable characterisation of chloroquine accumulation in this organelle in terms of time-, temperature-, Mg²⁺-, pH-, ATP- and other nucleotide-dependence. The chloroquine accumulating capabilities of vacuoles isolated from chloroquine-resistant and chloroquine-sensitive parasites were compared. At an external chloroquine concentration of 100 and 250nM vacuoles isolated from two chloroquine-sensitive strains accumulated significantly more chloroquine (± 3 x) than those isolated from three of the four chloroquine-resistant strains of Plasmodium falciparum tested. Although it is often suggested that the parasite digestive vacuole is involved in the mechanism of chloroquine-resistance, this is the first direct evidence to suggest this. Vacuolar proton pump inhibitors, proton gradient dissipaters, P-glycoprotein ATPase- and drug transport-inhibitors, weak bases, and structural analogues of chloroquine were used to examine the driving force of chloroquine accumulation in the isolated food vacuole. A pH gradient between the vacuole and cytoplasm is necessary to retain chloroquine in this organelle, but a chloroquine transport mechanism appears to be the main driving force in chloroquine accumulation. A polyclonal antibody directed at Pgh1, a Plasmodium falciparum homologue of P-glycoprotein, confirmed its presence on the vacuole, but was unable to inhibit chloroquine accumulation in isolated vacuoles. This thesis also shows that agents, such as verapamil, which are able to reverse chloroquine-resistance by increasing chloroquine accumulation in parasitised erythrocytes, are unable to increase chloroquine accumulation in the isolated vacuole, suggesting the involvement of an alternate site for the reversal of chloroquine-resistance.
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Murphy, Kevin Vincent. "Design and Synthesis of Novel Chloroquine-based Antimalarials." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2623.

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Malaria is an infectious, often fatal disease that afflicts nearly 200 million people every year. The disease, characterized by recurring and extreme flu-like symptoms, is caused by the protozoan parasite Plasmodium falciparum. Victims usually contract the disease through a mosquito vector. Chloroquine is a chemotherapeutic that was introduced in the 1940s. For many years the drug was the foremost treatment of malaria, being effective and producing few side effects. Unfortunately, tolerance to chloroquine developed when the parasite evolved a resistance mechanism. Newer drugs have been developed and implemented, but these medicines also show a decreasing effect with continued administration. It is imperative that a new pipeline of drugs be developed in order to combat the disease and anticipated resistance. Reversed chloroquines are a new class of multiple-ligand compounds that are active against chloroquine-sensitive and chloroquine-resistance malaria species. This thesis describes research targeted at the modification of lead reversed chloroquine molecules to discover new and effective moieties, as well as to improve pharmacokinetic-related properties. An especial emphasis of this project is the addition of a sulfonamide functional group to a reversed chloroquine. Preliminary evidence indicates that this is a promising direction for this line of research. Brief discussions of some reversed chloroquine characterization studies are included in appendices.
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Books on the topic "Chloroquine"

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Browning, David J. Hydroxychloroquine and Chloroquine Retinopathy. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3.

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Malaria-Selbstmedikation mit Chloroquin in einem hyperendemischen Gebiet (Mali). Frankfurt am Main: Peter Lang, 2001.

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Takanori, Gotō. Japan's dark side to progress: The struggle for justice for pharmaceutical victims of Japan's post war economic boom. Chiba, Japan: Manbousha, 1991.

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Takanori, Gotō. Japan's dark side to progress: The struggle for justice for pharmaceutical victims of Japan's post war economic boom. Chiba, Japan: Manbousha, 1991.

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Sharan, Sumit. Effects of chloroquine on MCF7-ADR and MCF7-WT human breast cancer cell lines. Sudbury, Ont: Laurentian University, 1998.

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Gotō, Takanori. Japan's dark side to progress: The struggle for justice for pharmaceutical victims of Japan's post war economic boom. Chiba, Japan: Manbousha, 1991.

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Singh, Sonia. Effects of chloroquine on growth and energy metabolism of MCF7-ADR and MCF7-WT human breast cancer cell lines. Sudbury, Ont: Laurentian University, 1999.

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Mazonde, Isaac Ncube. Malaria epidemiological case study: An assessment of the attitudes of the risk population towards curative chloroquin tablets in Ngamiland, North West Botswana. Gaborone: National Institute of Development Research and Documentation, University of Botswana, 1988.

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War and disease: Biomedical research on malaria in the twentieth century. New Brunswick, N.J: Rutgers University Press, 2009.

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Aigbirhio, E. E. Degradation of chloroquine sulphate. 1986.

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Book chapters on the topic "Chloroquine"

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Gooch, Jan W. "Chloroquine." In Encyclopedic Dictionary of Polymers, 882. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13385.

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de Groot, Anton C. "Chloroquine." In Monographs In Contact Allergy, 279–80. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-126.

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Jones, Alison L. "Chloroquine and Quinine." In Critical Care Toxicology, 1–16. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-20790-2_99-1.

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Medina, Carlos A. "Chloroquine/Hydroxychloroquine Toxicity." In Manual of Retinal Diseases, 429–32. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20460-4_85.

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Jones, Alison L. "Chloroquine and Quinine." In Critical Care Toxicology, 1271–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-17900-1_99.

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Browning, David J. "Preclinical Foundations: Relevant Anatomy and Physiology." In Hydroxychloroquine and Chloroquine Retinopathy, 1–34. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_1.

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Browning, David J. "Clinical Examples in Managing Patients Taking 4-Aminoquinolines." In Hydroxychloroquine and Chloroquine Retinopathy, 247–86. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_10.

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Browning, David J. "Pharmacology of Chloroquine and Hydroxychloroquine." In Hydroxychloroquine and Chloroquine Retinopathy, 35–63. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_2.

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Browning, David J. "Toxicology of Hydroxychloroquine and Chloroquine and the Pathology of the Retinopathy They Cause." In Hydroxychloroquine and Chloroquine Retinopathy, 65–83. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_3.

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Browning, David J. "Definitions of Hydroxychloroquine and Chloroquine Retinopathy." In Hydroxychloroquine and Chloroquine Retinopathy, 85–94. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0597-3_4.

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Conference papers on the topic "Chloroquine"

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Sari, Dewi Indra, and Mardiati Nadjib. "The Role of Chloroquine and Hydroxychloroquine in Prophylaxis of Covid-19: A Literature Review." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.33.

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ABSTRACT Background: A pandemic potential Covid-19 spread rapidly worldwide. Ministry of Health, Republic Indonesia recommended one of the Covid-19 treatments with combination of hydroxychloroquine/ chloroquine and azithromycin. However, the effectiveness and safety of antimalaria regime remain debating topic. This study aimed to investigate the role of chloroquine and hydroxychloroquine in prophylaxis of Covid-19. Subjects and Method: A systematic review was conducted by searching from PubMed, SpringerLink, and Cochrane Library databases. The keywords were “prophylaxis”, “chloroquine” OR “hydroxychloroquine” “SARS-CoV-2” OR “Covid-19”. The inclusion criteria were phase IIb clinical trials, double masking, comparative observational studies, open access articles published until August 2020. The exclusion criteria were inaccessible and duplicate articles. The quality of selected articles was critically appraised. The data were reported by PRISMA flow chart. Results: Three articles out of 117 articles met the criteria inclusion. The findings showed that hydroxychloroquine could not prevent Covid-19 compatible disease or confirmed infections when used as post-exposure prophylaxis. High dose chloroquine was not recommended for critically ill COVID-19 patients because of its potential side effects, especially when administered with azithromycin and oseltamivir. Covid-19 patients with the need for oxygenation were not suggested to use hydroxychloroquine. Conclusion: There is scarce evidence to support prophylaxis and treatment effects of chloroquine or hydroxychloroquine in COVID-19 patients. Further research on the safety and use of chloroquine or hydroxychloroquine is required in the management of Covid-19. Keywords: prophylaxis, Chloroquine, Hydroxychloroquine, SARS-CoV-2, Covid-19 Correspondence: Dewi Indra Sari. Masters Program in Public Health, Faculty of Public Health, Universitas Indonesia, Depok, West Java. Email: dindrasang@yahoo.com. Mobile: +628121983-6600. DOI: https://doi.org/10.26911/the7thicph.05.33
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Pihlajoki, Marjut, Katja Eloranta, Antti Kyrönlahti, and Markku Heikinheimo. "Abstract 5408: Chloroquine inhibits PARP expression in hepatoblastoma." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5408.

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Amaravadi, Ravi K. "Abstract SY01-04: Chloroquine derivatives as anticancer agents." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-sy01-04.

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Pedrosa, Leandro F., Antônia C. R. Furtado, Carolina T. Machado, Raphaela de M. Baêsso, Neidemar de M. S. Bastos, William P. de Macedo, and Marcos C. Souza. "Design and Synthesis of New Phosphoramidates Chloroquine Analogs." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0213-2.

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Casado, E., M. Larrosa, J. Gratacos, J. Font, JM Martinez, and C. Tolosa. "OP0131 Chloroquine myopathy: prevalence and clinical features (preliminary data)." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.581.

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Gonzalez-Dominguez, J., M. Santos, A. Escudero, A. Cisnal, M. Romero, V. Perez, MD Lopez, et al. "THU0203 Incidence of chloroquine retinopahy in rheumatoid arthritis patients." In Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.1105.

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Wang, Lei, Yan Cheng, Hua Xiong, Xiaolan Guo, Junxuan Lu, and Yibin Deng. "Abstract 4902: Targeting APC mutant colon cancer cells by chloroquine." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4902.

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Espina, Virginia A., Lance Liotta, Svetlana Rassulova, Holly Gallimore, Thalia Grant-Wisdom, Geetha Menezes, Hassan Nayer, and Kirsten Edmiston. "Abstract CT140: PINC trial: Preventing invasive breast neoplasia with chloroquine." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-ct140.

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Dunmore, Benjamin J., Lu Long, Xudong Yang, Alexi Crosby, and Nicholas W. Morrell. "Treatment With Chloroquine Increases Cell Surface Expression Of BMPR-II." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2518.

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Denu, Ryan A., and Mark E. Burkard. "Abstract A01: Centrosome amplification induces autophagy and sensitizes to chloroquine." In Abstracts: AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.pmccavuln16-a01.

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Reports on the topic "Chloroquine"

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Kendrick, Kelsie. Mimicking Metabolism of a Reversed Chloroquine Antimalarial. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2083.

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Murphy, Kevin. Design and Synthesis of Novel Chloroquine-based Antimalarials. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2619.

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Tesfaselassie, Elias. Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2503.

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Kyle, Dennis E., Wilbur K. Milhous, and Richard N. Rossan. Reversal of Plasmodium Falsiparum Resistance to Chloroquine in Panamanian Aotus Monkeys. Fort Belvoir, VA: Defense Technical Information Center, January 1993. http://dx.doi.org/10.21236/ada263042.

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Xia, Yuan, Ai Peng, Mingying Li, Dongmei Wang, Xiuhua Su, Yuyan Wu, Guosheng Li, Tao Sun, and Chunyan Ji. Chloroquine and hydroxychloroquine for treatment of COVID-19: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0110.

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Dacso, Clifford C., S. Hilsenbeck, M. Bondy L., K. Sexton, O. Conneely, A. Harris, K. McArthur, P. Mayfield, and A. McOwiti. A Translational Approach to Validate in Vivo Anti-tumor Effects of Chloroquine on Breast Cancer Risk. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada586025.

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Chang, Raymond. A systematic review of randomized clinical trials assessing the prophylactic efficacy or chloroquine or hydroxychloroquine against COVID-19. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0101.

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Zhao, Yuwei, Wu Sun, Runzhi Qi, Xue Mi, Liang Liao, Mengqi Cheng, Zhonghui Zhao, et al. Chloroquine combined with azithromycin in the treatment of novel coronavirus (COVID-19) pneumonia: study protocol for a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0044.

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Liu, Yan, Xiaoxu Fu, and Chunguang Xie. Efficacy and safety of chloroquine and hydroxychloroquine in the treatment of patients with COVID-19 combined with diabetes mellitus a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2020. http://dx.doi.org/10.37766/inplasy2020.7.0109.

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10

Gunsaru, Bornface. Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.400.

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