Dissertations / Theses on the topic 'Chiral analysis'
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Layton, Sherry E. "Comparison of various chiral stationary phases for the chromatographic separation of chiral pharmaceuticals /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/laytons/sherrylayton.pdf.
Full textFulwood, Russell. "Chiral analysis by NMR spectroscopy." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/5979/.
Full textPenn, Sharron Gaynor. "Chiral analysis by capillary electrophoresis." Thesis, University of York, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241074.
Full textMertzman, Melissa Danielle Foley Joe Preston. "Chiral microemulsion electrokinetic chromatography /." Philadelphia, Pa. : Drexel University, 2004. http://dspace.library.drexel.edu/handle/1860/340.
Full textModzabi, Selorm Kwame Busch Kenneth W. Busch Marianna A. "Studies on new approaches of chiral discrimination for chiral analysis by regression modeling of spectral data." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5349.
Full textKahle, Kimberly Ann Foley Joe Preston. "Effect of identity and number of chiral microemulsion components in chiral microemulsion electrokinetic chromatography /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1293.
Full textCarlsson, Björn. "From achiral to chiral analysis of citalopram." Doctoral thesis, Linköpings universitet, Klinisk farmakologi, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5217.
Full textOn the day of the public defence the status of article IV was: Submitted.
Carlsson, Björn. "From achiral to chiral analysis of citalopram /." Linköping : Univ, 2003. http://www.ep.liu.se/diss/med/07/93/index.html.
Full textLundgren, Stina. "Efficient Synthesis and Analysis of Chiral Cyanohydrins." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan (KTH), 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4315.
Full textKröner, Dominik (Dr rer nat ). "Analysis and control of light-induced processes in molecules: Electron and nuclear quantum dynamics for aspects of stereoisomerism and spectroscopy." Thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2014/7047/.
Full textDie Habilitationsschrift behandelt theoretische Untersuchungen von durch Licht ausgelösten Prozessen in Molekülen. Der Schwerpunkt liegt dabei auf Veränderungen in der Elektronenstruktur und der Geometrie der Moleküle, die durch Bestrahlung mit Licht entweder bei einer spektroskopischen Untersuchung oder bei gezielter Kontrolle durch geformte Laserpulse herbeigeführt werden. Um die dabei auftretende Elektronen- und Kerndynamik zu simulieren, wurden vornehmlich quantentheoretische Methoden eingesetzt und weiterentwickelt. Die wissenschaftlichen Fragestellungen beschäftigen sich mit dem gezielten Verändern und dem Erkennen der räumlichen Struktur von Molekülen ohne Drehspiegelachse, der sog. molekularen Chiralität, sowie mit durch Licht eingeleiteten Prozessen in biologisch relevanten Pigmenten auf sehr kurzen Zeitskalen. Die entwickelten Ansätze und gewonnenen Erkenntnisse lassen sich drei Haupterfolge unterteilen: Erstens gelang die Entwicklung einer generellen Kontrolltheorie für das Ein- und Umschalten von molekularer Chiralität mit geformten Laserpulsen. Dabei wird die räumliche Struktur der vorgeschlagenen molekularen Schalter zwischen ihren stabilen sog. stereoisomeren Formen selektiv geändert, was sich auf ihre optischen und chemischen Eigenschaften auswirkt. Für komplexere Bedingungen, wie z.B. auf einer Oberfläche verankerten molekularen Schaltern verschiedener Orientierung, wurde eine neue Pulsoptimierungsmethode basierend auf Wahrscheinlichkeiten und Statistik entwickelt. Solche laserpulskontrollierten chiralen molekularen Schalter hofft man u.a. in der Nanotechnologie zum Einsatz zu bringen, wo sie z.B. als Informationsspeicher dienen könnten. Zweitens konnte geklärt werden, welche die wesentlichen Einflüsse sind, die das Erkennen von sog. Enantiomeren, das sind spiegelbildliche Moleküle von entgegengesetzter Chiralität, nach Ionisierung durch ultrakurze zirkular polarisierte Laserpulse ermöglichen. Diese Form des sog. Zirkulardichroismus in der Ionenausbeute erlaubt die quantitative und qualitative Unterscheidung von Enantiomeren in der Massenspektrometrie. Durch Simulation der Elektronendynamik während der Laseranregung konnte u.a. erstmals gezeigt werden, dass neben der Zirkularpolarisation der Laserpulse vor allem die schwachen magnetischen Wechselwirkungen für die Unterscheidung entscheidend sind. Drittens wurden die Spektren von in der Natur vorkommenden Pigmenten simuliert, welche u.a. an wichtigen biologischen Funktionen, wie dem Sammeln von Sonnenenergie für die Photosynthese, beteiligt sind. Die Lichtanregung führt dabei zu einer Veränderung der Elektronenstruktur und Geometrie der Pigmente, wobei letzteres wichtige Konsequenzen für die Verteilung der Energie auf die spektroskopisch beobachteten Molekülschwingungen mit sich bringen. Auch der wichtige Einfluss der biochemischen Umgebung auf die Elektronenstruktur der Pigmente bzw. den Energietransfer zwischen solchen wurde untersucht. Neben der Klärung experimenteller Ergebnisse ermöglichen die Untersuchungen neue Einblicke in die fundamentalen Prozesse kurz nach der Lichtanregung -- Erkenntnisse, die auch für die technische Nachahmung der biologischen Funktionen von Bedeutung sein können.
Nhujak, Thumnoon. "Quantitative aspects of capillary electrophoresis and chiral analysis." Thesis, University of York, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270036.
Full textThomason, Michael John. "The microbial chiral inversion of drug molecules." Thesis, University of Brighton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284046.
Full textKluskens, Michael S. "Method of moments analysis of scattering by chiral media /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688507504775.
Full textMiyahara, Kenta. "Analysis of Λ(1405) based on chiral SU(3) dynamics." Kyoto University, 2018. http://hdl.handle.net/2433/232249.
Full textHe, Jun. "Chiral Analysis Using Capillary Electrophoresis Coupled to Mass Spectrometry: Development of Novel Modes and Applications Using Molecular Micelles and Surfactant-Bound Monolithic Columns." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/61.
Full textWiberg, Karin. "Enantiospecific Analysis and Environmental Behavior of Chiral Persistent Organic Pollutants (POPs)." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9.
Full textCrabb, Nicholas Clive. "Applications of chiral chromatography to the analysis of drugs and herbicides." Thesis, University of Bradford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277117.
Full textIngle, Jemima Rose Busch Kenneth W. Busch Marianna A. "Studies on regression modeling of spectral data as a means of chiral analysis." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4820.
Full textCurrie, Christa Anne. "Capillary and Microchip Electrophoresis Systems for Pharmaceutical Analysis." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242998601.
Full textReilly, John. "A comparison of electrophoretic and chromatographic separation techniques for the determination of chiral and achiral impurities." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270880.
Full textMorrison, Calum M. "Chiral and achiral analysis of benzodiazepine and anti-anginal drugs in forensic toxicology." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321443.
Full textEdwards, Andrew John. "An NMR isotope labelling analysis of calmodulin interactions with high affinity chiral inhibitors." Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267964.
Full textUrano, Nobuyuki. "Studies of microbial aminoalcohol dehydrogenase : biochemical analysis and application to chiral compound production." Kyoto University, 2007. http://hdl.handle.net/2433/136512.
Full text0048
新制・課程博士
博士(農学)
甲第13092号
農博第1597号
新制||農||938(附属図書館)
学位論文||H19||N4218(農学部図書室)
UT51-2007-H365
京都大学大学院農学研究科応用生命科学専攻
(主査)教授 清水 昌, 教授 喜多 恵子, 教授 江﨑 信芳
学位規則第4条第1項該当
Grosman, Donald Michael. "Southern pine beetle, Dendroctonus frontalis Zimmermann (Coleoptera: Scolytidae) : quantitative analysis of chiral semiochemicals /." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-05042006-164540/.
Full textZheng, Jie. "Development of Chiral/Achiral Analysis Methods using Capillary Electrochromatography and Capillary Electrochromatography Coupled to Mass Spectrometry." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_diss/6.
Full textHofacker, Amanda Lynn. "Analysis of cooperative, correlated motions in dynamic chiral secondary conformational states of macromolecular dendritic structures." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1155049363.
Full textWatt, Alan Paul. "Liquid chromatographic and mass spectrometric methods for the chiral analysis of drugs and drug metabolites." Thesis, University of Hertfordshire, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421286.
Full textSayad, D., C. Zebiri, Issa T. Elfergani, Jonathan Rodriguez, Raed A. Abd-Alhameed, and F. Benabdelaziz. "Analysis of Chiral and Achiral Medium Based Coplanar Waveguide Using Improved Full Generalized Exponential Matrix Technique." RadioEngineering, 2020. http://hdl.handle.net/10454/18304.
Full textIn this work, an analytical study of the electromagnetic propagation in a complex medium-based suspended three-layer coplanar waveguide (CPW) is carried out. The study aims at a numerical calculation of the dominant hybrid mode complex propagation constant in the CPW printed on a bianisotropic substrate. The herein considered bianisotropy is characterized by full 3×3 tensors of permittivity, permeability and magnetoelectric parameters. The study is based on the numerical derivation of the Green's functions of such a complex medium in the spectral domain. The study is carried out using the Full Generalized Exponential Matrix Technique based on matrix- shaped compact mathematical formulations. The Spectral Method of Moments (SMoM) and the Galerkin's procedure are used to solve the resulting homogeneous system of equations. The effect of the chiral and achiral bianisotropy on the complex propagation constant is particularly investigated. Goo d agreements with available data for an anisotropic-medium-based suspended CPW structure are achieved. Various cases of chiral and achiral bianisotropy have been investigated, and particularly, the effect on the dispersion characteristics is presented and compared with cases of isotropic and bianisotropic Tellegen media.
FCT/MEC through national funds and when applicable co-financed by the ERDF, under the PT2020 Partnership Agreement under the UID/EEA/50008/2019 project.
Cantillana, Tatiana. "Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics." Doctoral thesis, Stockholms universitet, Institutionen för miljökemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-26952.
Full textStauffer, Scott T. "Expert system shells in chemistry : CHIRULE, a chiral chromatographic column selection system using similarity searching and personal construct theory /." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10042006-143845/.
Full textVita. Abstract. Vol. 2 is appendices. Includes bibliographical references (leaves 327-337). Also available via the Internet.
Marchant, Carol A. "NMR studies of the cyclodextrin complexes of some 2-arylpropionates and their application to chiral analysis." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303408.
Full textBendazzoli, Claudia <1981>. "Studies on the interaction of surfactants and neutral cyclodextrins by capillary electrophoresis. Application to chiral analysis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1495/1/Claudia_Bendazzoli_Tesi.pdf.
Full textBendazzoli, Claudia <1981>. "Studies on the interaction of surfactants and neutral cyclodextrins by capillary electrophoresis. Application to chiral analysis." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1495/.
Full textZu, Chengli. "Enantiomer analysis using electrospray ionization mass spectrometry." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-04092007-103342.
Full textCheng, Jiaji. "Fine-tuned silica nanohelices as platforms for chiral organization of gold nanoparticles : synthesis, characterization and chiroptical analysis." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0423/document.
Full textSilica nanomaterials can be easily fabricated, fashioned and functionalized as platforms for grafting of nanoparticles for biomedical and optical applications. Herein, we utilize a template-based methodology to prepare a diverse collection of helical gold nanoparticle (GNPs) superstructures having controllable handedness and structural metrics by using GNPs as the building blocks, and the silica nanohelices as the template. The synthesized materials exhibit well-defined chiral arrangement of GNPs following the helicity of silica nanohelices, showing plasmonic circular dichorism (CD) signals. Further observations proved this plasmon CD comes from the chiral arrangement of GNPs and this effect is highly size, scale and pH dependent. We expect that this assembly strategy will discover a better view towards metamaterials and spark the view towards “bottom-up” approaches in nanoscience
Borgogno, Andrea. "Chiral discrimimation and structural analysis of organic molecules by nmr in oriented polypeptide solutions: a computational investigation." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422960.
Full textLa spettroscopia NMR in soluzioni liquido cristalline di polipeptidi è utilizzata da una ventina d’anni e si è rivelata applicabile con ottimi risultati, sia per la determinazione strutturale, si per la discriminazione chirale di molecole organiche. Tuttavia il meccanismo che ne sta alla base rimane poco chiaro e ci sono molte questioni irrisolte. Queste riguardano la natura delle forze che controllano la distribuzione anisotropica dei soluti; non si conosce, ad esempio, quale possa essere il ruolo di interazioni specifiche, come legami idrogeno. Inoltre gli effetti del cosolvente e della temperatura non sono chiari, non si è capito se incidano direttamente sulle interazioni soluto-peptide oppure se abbiano un effetto indiretto, andando a modificare la struttura del polipeptide stesso. La scarsa comprensione costituisce un limite che impedisce di sfruttare appieno le potenzialità della tecnica NMR in cristalli liquidi. Una maggiore padronanza del fenomeno sarebbe un importante punto di partenza per ottimizzare le condizioni di lavoro; ad esempio si potrebbe scegliere con più cognizione il sistema peptide-cosolvente ideale per un determinato soluto. Un aspetto particolarmente interessante riguarda la discriminazione chirale: si sa che avviene perché l’interazione di coppie di enantiomeri con i polipeptidi chirali origina coppie di diastereoisomeri, ma non è noto quali forze ne siano responsabili. In questa tesi si è studiato il comportamento di soluzioni liquido-cristalline di poli(γ-benzil-glutammato) utilizzando metodi computazionali. Il lavoro teorico è stato svolto in collaborazione con un gruppo sperimentale del laboratorio del Laboratoire de RMN en Milieu Orienté, Institut de Chimie Moléculaire d’Orsay de l’Université de Paris Sud, 11 (ICMMO), che ha sviluppato una competenza specifica nelle tecniche NMR in fasi di cristallo liquido. I risultati teorici sono stati confrontati con quelli dati NMR; inoltre, in parallelo ai calcoli, sono stati eseguiti nuovi esperimenti, in modo tale da controllare la consistenza tra risultati teorici e sperimentali. Uno degli obiettivi principali della tesi è stato quello di sviluppare nuovi strumenti computazionali per l’analisi dei dati sperimentali con il duplice scopo di (i) essere un supporto per l’interpretazione spettrale e (ii) estrarre le informazioni strutturali contenute nei dati sperimentali. Nella tesi si è fatto esplicito riferimento a esperimenti in abbondanza naturale di deuterio (NAD 2D-NMR), perciò ci si è focalizzati su splitting quadrupolari di deuterio; tuttavia i metodi utilizzati possono essere estesi ad altri tipi di interazioni amgnetiche. Si sono utilizzati approcci diversi per affrontare il problema della discriminazione chirale e quello dell’analisi strutturale. I meccanismi che portano a discriminazione chirale sono stati investigati attraverso simulazioni di Dinamica Molecolare (MD) a livello atomistico. La scelta è stata dettata dalla constatazione che le differenze di ordine orientazionale, e quindi le differenze spettrali, tra coppie di enantiomeri sono molto piccole e possono dipendere da dettagli delle interazioni intermolecolari. Questa è una caratteristica fondamentale delle proprietà chirali, che sono il risultato di un bilanciamento delicato di contributi energetici di entità comparabile comparabili. Innanzitutto lo studio ha avuto uno scopo esplorativo: si è voluto valutare se metodi basati su potenziali intermolecolari empirici possano fornire informazioni affidabili di proprietà chirali in fase condensata. Sono stati studiati alcuni soluti, ma la maggior parte del lavoro si è concentrata sull’alcol benzilico (BZA), una molecola prochirale che si è rivelata particolarmente adatta allo scopo per più di un motivo. Innanzitutto essa presenta una differenza relativamente grande tra gli splitting quadrupolari di deuterio per le due direzioni enantiotopiche; inoltre ha il vantaggio di potere essere usata come solvente, e questo permette di aumentare l’efficienza del campionamento nelle simulazioni MD. Per quanto riguarda la determinazione strutturale, il problema è meno delicato in quanto le differenze sperimentali tra i parametri d’ordine di molecole con strutture diverse sono relativamente più grandi. Ciò significa che dal punto di vista teorico è possibile sviluppare modelli approssimati, che sono utili per razionalizzare il meccanismo alla base dell’ordine dei soluti. Inoltre la possibilità di mettere a punto approcci in grado di fornire stime dei parametri d’ordine, e quindi pattern di splitting quadrupolari, a un costo computazionale non troppo elevato, è essenziale per lo sviluppo di metodologie integrate con gli esperimenti. Questa tesi è quindi sviluppata in due parti. Nella prima parte ci si è concentrati sul problema della determinazione strutturale. Nel capitolo 3 viene presentato il modello del cilindro rigido, che permette di calcolare gli splitting quadrupolari di un soluto sulla base della sua struttura, partendo dall’ipotesi che le interazioni soluto-polipeptide siano essenzialmente di tipo sterico. Nel capitolo 4 sono riportate le metodologie computazionali sviluppate per il calcolo dei profili di splitting quadrupolari di soluti flessibili, utilizzando il modello del cilindro rigido accoppiato con un campionamento adeguato dello spazio conformazionale. Nel capitolo 5 si trova l’applicazione di questo metodo ad una serie di esteri metilici di acidi grassi saturi (C14-C18). Il capitolo 6 riporta uno studio sistematico di esteri di acidi grassi saturi, insaturi e insaturi coniugati, nel quale si mostra come i parametri torsionali possono essere estrapolati dal profilo degli splitting quadrupolari. La seconda parte della tesi riguarda la discriminazione chirale. Nel capitolo 7 si riportano i risultati di una serie sistematica di esperimenti NMR sull’alcol benzilico, condotti presso i laboratori dell’ICMMO. Il capitolo 8 è invece dedicato alle simulazioni di Dinamica Molecolare. Innanzitutto viene presentato uno studio preliminare sul PBLG in cloroformio, eseguito per validare la parametrizzazione del campo di forze utilizzato per questo polipeptide. Quindi sono riportati i risultati ottenuti per l’alcol benzilico in miscele liquido-cristalline binarie e ternarie.
Yeung, Kai Tai. "Molecular simulations of the enantioseparating mechanism of polysaccharide-based chiral stationary phase and enzymatic acylation of N-benzoyl-L-arginine ethyl ester in binary aquo-organic solvent mixtures." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/819.
Full textSantana, Fernando José Malagueño de. "Análise enantiosseletiva da mirtazapina e seus metabólitos: técnicas modernas de microextração e análise e aplicação em estudos de disposição cinética." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-24112008-085140/.
Full textThe need for appropriate methodology for the analysis of drugs and their metabolites in complex biological matrices led to a growing interest in developing new techniques for sample preparation, particularly microextraction techniques because they are highly selective and require a minimum consumption of organic solvents. Allied to these developments, the employment of modern and efficient analytical technologies, such as capillary electrophoresis (CE) and high-performance liquid chromatography coupled to mass spectrometry (LC-MS-MS), has resulted in a considerable improvement in quality in the analytical methodologies available for bioanalysis. In this context, it is worth to mention the use of such techniques to develop enantioselective methodologies, allowing the quantification of the enantiomers of drugs administered as racemates. Therefore, we proposed the development and validation of enantioselective methodologies for the analysis of the enantiomers of mirtazapine (MRT) and of its main metabolites in plasma and urine, using the CE and LC-MS-MS. Solid phase microextraction (SPME) and liquid phase microextraction (LPME) were used for sample preparation. In the first method, LPME was used to extract the analytes from plasma samples (1 ml), previously diluted, alkalinized with 3.0 mL 0.5 mol L-1 pH 8 phosphate buffer solution and supplemented with 15% (w/v) sodium chloride. N-hexyl ether and 0.01 mol L-1 acetic acid solution were used as solvent extractor and acceptor phase, respectively. The analyses were carried out on a CHIRALPAK AD-RH column and acetonitrile: methanol: ethanol (98:1:1, v / v / v) plus 0.2% of diethylamine was used as mobile phase, at a flow rate of 1 mL min-1. The detection was performed by LC-MS-MS equipped with a triple-quadrupole analyzer and ionization by eletrospray positive. Under these conditions, recoveries were from 18.3 to 45.5%; linear response over the 1,25-125 ng ml-1 concentration range and limit of quantification (LOQ) of 1.25 ng ml-1 for all enantiomers evaluated were obtained. CE and LPME were also used for the analysis of MRT and its main metabolites in urine. Before the extraction, urine samples (1 mL) were submitted to enzymatic hydrolysis at 37 ºC for 16 hours, the enzyme was precipitated with trichloroacetic acid, the pH was adjusted to 8 with 0.5 mol L-1 phosphate buffer solution (pH 11) and 10% (w/v) sodium chloride was further added. Then, the LPME extraction was performed according to the procedure previously developed. The electrophoretic analyses were carried out in 50 mmol L-1 phosphate buffer solution (pH 2.5) containing 0.55% (w/v) carboxymethyl-b-cyclodextrin (CM-b-CD). The method was linear over the concentration range of 62.5-2500 ng mL-1 for each MRT and 8-OHM enantiomer and 62.5-1250 ng mL-1 for each DMR enantiomer. The quantification limit (LOQ) was 62.5 ng mL-1 for all the enantiomers. A SPME method was also developed for the simultaneous enantioselective determination of MRT and its metabolites in urine using CE and LC-MS-MS. The target analytes were transferred from the hydrolyzed aqueous solution to the polydimetylsiloxane-divinylbenzene (PMDS-DVB) fiber coating and then desorbed in methanol. The means recoveries were 12 % for the enantiomers of MRT, 3.8 % for DMR and 0.72 % for 8-OHM. The method was linear over the concentration range of 62.5-2500 ng mL-1 with suitable LOQ (62.5 ng mL-1) for all the enantiomers. The precision and accuracy were lower than 15% for all developed methods. Moreover, the methods were successfully employed for the determination of MRT, 8-OHM and DMR enantiomers in plasma and urine samples obtained after oral administration of a single dose of rac-MRT to healthy volunteers.
Tarver, John A. (John Arthur). "Chemical Ionization (CI) GC/MS Analysis of Underivatized Amphetamines Followed by Chiral Derivatization to Identify d and l-Isomers with Ion Trap Mass Spectrometry." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc504248/.
Full textBarclay, Victoria K. H. "Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171550.
Full textDogra, Jody A. Busch Kenneth W. Busch Marianna A. "Multivariate analyses of near-infrared and UV spectral data." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5347.
Full textDang, Viet D. "Achiral and chiral analysis of polychlorinated biphenyls (PCBs) in the aquatic and riparian food webs in Twelve Mile Creek, South Carolina." Connect to this title online, 2007. http://etd.lib.clemson.edu/documents/1202410243/.
Full textDesai, Meera Jay. "Development of Chiral LC-MS Methods for small Molecules and Their Applications in the Analysis of Enantiomeric Composition and Pharmacokinetic Studies." Ames, Iowa : Oak Ridge, Tenn. : Ames Laboratory ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2004. http://www.osti.gov/servlets/purl/837266-GaBf1y/webviewable/.
Full textPublished through the Information Bridge: DOE Scientific and Technical Information. "IS-T 2134" Meera Jay Desai. US Department of Energy 12/19/2004. Report is also available in paper and microfiche from NTIS.
Martinez, Stephanie. "Pharmacokinetic and pharmacodynamic investigations of select natural products and nutraceuticals for human and veterinary health." John Wiley & Sons, Ltd, 2013. http://hdl.handle.net/1993/31166.
Full textMay 2016
Krait, Sulaiman [Verfasser], Gerhard [Gutachter] Scriba, Oliver [Gutachter] Werz, and Schepdael Ann [Gutachter] Van. "Capillary electrophoresis methods for chiral drug analysis and cyclodextrin-guest complexation mechanisms / Sulaiman Krait ; Gutachter: Gerhard Scriba, Oliver Werz, Ann Van Schepdael." Jena : Friedrich-Schiller-Universität Jena, 2021. http://d-nb.info/123135657X/34.
Full textIguiniz, Marion. "Développement de méthodes bidimensionnelles en ligne LCxLC-UV/MS et LCxSFC-UV pour l’analyse de composés pharmaceutiques." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1200/document.
Full textTwo-dimensional liquid chromatography (2D-LC) is a powerful technique considering its high separation power. After showing the advantage of 2D-LC in the pharmaceutical area and presenting the challenges related to quantitative analysis, special attention was paid to method development. With the aim of developing a generic analytical strategy for pharmaceuticals, the first step of our approach consisted in selecting a set of three 2D-systems with the help of a methodology previously developed. In a second step, the potential of these 2D-systems was evaluated for the purpose of quantitative analysis. An analytical strategy able to be applied to pharmaceutical analysis in an industrial context was proposed. Finally, the potential of RPLCxSFC was investigated in two different cases. Firstly, for comparing this on-line two dimensional technique to on-line RPLCxRPLC with respect of the separation power. Secondly, for chiral compounds by developing a selective RPLCxSFC method for simultaneous achiral-chiral analysis. The advantage of such method was highlighted by comparing to conventional approaches
Bång, Joakim. "Purification, Stereoisomeric Analysis and Quantification of Biologically Active Compounds in Extracts from Pine Sawflies, African Butterflies and Orchid Bees." Doctoral thesis, Mittuniversitetet, Institutionen för naturvetenskap, teknik och matematik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-14662.
Full textMånga naturligt förekommande kemiska ämnen finns som två spegelbilder av varandra, ungefär som höger och vänster hand. Dessa kan ha helt olika egenskaper och det är därför viktigt att kunna separera dem. Insekter och andra djur använder olika doftämnen för att kommunicera med varandra, om det är inom samma art kallas de för feromoner. De kan bestå av ett ämne eller en blandning av flera. Dessa doftämnen kan man även använda för att på ett miljövänligt sätt bekämpa skadeinsekter. En fälla med syntetiskt feromon för en viss insekt lockar endast till sig den arten, medan alla andra är opåverkade. Eftersom dessa ämnen ofta finns som spegelbilder där kanske bara den ena är aktiv och den andra rent av frånstötande, måste man kunna separera dem för att framställa ett syntetiskt feromon som är attraktivt. Målet med detta arbete har varit att bestämma feromonet hos olika arter av tallsteklar som kan vara svåra skadedjur på tallskog. De metoder som tagits fram har även tillämpats på några arter av afrikanska fjärilar samt orkidébin från Centralamerika eftersom de använder snarlika doftämnen. Att få fram feromonet från en insekt är lite som att leta efter in nål i en höstack eftersom de ofta bara innehåller några miljarddels gram per individ. Provet behöver först renas, och en del av arbetet i det här projektet har gått ut på att ta fram en lämplig reningsmetod. Huvudfokus har dock varit på att ta fram metoder som kan separera och identifiera det eller de ämnen, och spegelbilder av dessa, som doftämnena består av. När lämpliga metoder tagits fram har extrakt av olika insektsarter analyserats. I några fall är det första gången som deras feromon bestämts i detalj. Resultaten kan förhoppningsvis bidra till en ökad kunskap om insekters sätt att kommunicera, och i slutändan till miljövänligare bekämpning av skadeinsekter.
Bejarano, Villafuerte Ángela. "Self-assembled monolayers and patterned surfaces derived from them as templates for the growth of chiral crystals." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/123572.
Full textThe research presented in this Thesis has as the main objective of the establish the effect of chiral self-assembled monolayers (SAMs) on the nucleation and the crystal growth of organic compound, and find conditions which favour heterogeneous nucleation and subsequent growth. The possibility to control crystallization processes using self-assembled monolayers is an extremely interesting and promising approach in organic materials. This control has achieved by the use of inorganic crystalline substrates where nucleation is induced via epitaxy, although organic single crystals and SAMs have been used to control the polymorphic selectivity of the compound to crystallize, which is based on the lattice match between the molecular cluster and crystalline substrate terraces. According to this concept, SAMs have been used as controlled nucleation centres. This research describes the study in order to achieve the controlled crystallization of the compound phencyphos and diastereomeric salts on functionalized surfaces, and shows the differences between homogenous SAMs and combined SAMs (Microcontact printing method). The controlled crystallisation study starts with the formation of SAMs on gold with a novel chiral thiol, which has potential for nucleating crystal growth, (phencyphos 4-methylenthiol, PMT), and the crystallisation of phencyphos on them. The functionalisation of gold with monolayers of this compound has provided significant results due to its demonstrated influence in the crystallisation process. Thus, the successful functionalisation of the gold substrate by this resolving agent type molecule provided the chiral property to the self-assembled monolayer on gold. Phencyphos crystallises on PMT monolayer following different orientations and grow off the surface; depending on the solvent used these crystals grow as branched crystals (in isopropanol) on the functionalised surface. The microcontact printing method favours the mass transport to the desired thiol, minimizing evaporation effect at small scale. The surface combined of PMT and dodecanethiol has been the key for the development of surfaces which can induce the nucleation process on surface. On micropatterned surfaces, phencyphos crystallizes following a preferential orientation. Crystal growth is highly depending on the solvent used to crystalize phencyphos. The same enantiomer of phencyphos crystallized in different solvent (Chloroform and Isopropanol), yield different crystal growth, because the heterogeneous nucleation is effective when the solvent is allowed to evaporate slowly from the surface, allowing good mass transport to the desired regions. The diastereomeric salt most studied and presented here is the one formed by a phencyphos derivate, p-methyl phencyphos which provides a pair of crystalline salts with chiral amines. X-ray crystal structure of this diastereomeric salt reveal 10-membered rings constructed through hydrogen bonds, in which two ammonium groups formally replace phencyphos molecules seen in the phencyphos hydrate structure. The hydrogen bonds are strong and provide several polar faces to the crystalline structure, thus diastereomeric salts should have their crystals templated easily on polar SAM. There are several parameters that also have a dramatic influence on the crystallisation process such as the pattern shape and size which are critical. Thus the motif size which presents better results of favour the nucleation is for dots of 5 μm diameter spaced by 10 μm, for both crystallisation systems. The Dutch resolution has been also studied on micropatterned surfaces. The complexity of the family type crystallisation will require the development of specific additives to favour heterogeneous nucleation.
Paramahamsan, Harinandini. "η6-Arenechromium Tricarbonyl Complexes: Conformational Analysis, Stereocontrol in Nucleophilic Addition and Applications in Organic Synthesis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1106262785.
Full textYanes, Santos Enrique Geovani. "STUDIES IN BIOANALYTICAL SEPARATIONS USING CAPILLARY ELECTROPHORESIS AND HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997383487.
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