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1

Scaramuzza, Andrea, Carine de Beaufort, and Ragnar Hanas, eds. Research into Childhood-Onset Diabetes. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-40242-0.

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2

Melissa, Pearrow, and Jimerson Shane R, eds. Identifying, assessing, and treating early onset schizophrenia at school. New York: Springer, 2010.

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3

Brunner, Hermine Isabella. Investigation of the relationship between disease activity and disease damage in childhood-onset systemic lupus erythematosus. Ottawa: National Library of Canada, 2001.

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4

Beside the mountain: Finding strength and courage through my father's early onset Alzheimer's disease. [California]: The Author., 2012.

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5

Zvi, Laron, and Karp Moshe, eds. Prognosis of diabetes in children: An update on early and late complications : proceedings of the 7th International Beilinson Symposium on Late Prognosis of Juvenile Onset Diabetes, Jerusalem, November 1-7, 1987. Basel: Karger, 1989.

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6

1971-, Yuzawa Miki, ed. Nihongo bogo yōji ni yoru Eigo onsei no chikaku hassei to gakushū: Nihongo bogo washa wa Eigo onsei no chikaku, hassei ga naze muzukashiku, dō gakushūsubeki ka. Tōkyō-to Chiyoda-ku: Kabushiki Kaisha Kazama Shobō, 2013.

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7

Rizvi, Waqar. Childhood-Onset Disorders. Edited by Rajiv Radhakrishnan and Lily Arora. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190265557.003.0014.

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This chapter provides a review of disorders first diagnosed in infancy, childhood, and adolescence including intellectual disability, learning disorders, motor skills disorders, communication disorders, attention deficit and disruptive behavior disorders, tic disorders, elimination disorders, kleptomania, and pyromania
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8

Fox, Claudine, and Carol Joughin. Childhood-onset Eating Problems. Gaskell, 2002.

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9

CHILDHOOD ONSET OF ANOREXIA NERVOS. Psych Press UK, 1993.

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10

MOFFITT, TERRIE E. CHILDHOOD-ONSET VERSUS ADOLESCENT-ONSET ANTISOCIAL CONDUCT PROBLEMS IN MALES. 1996.

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11

Green, Dido, and Christine Imms. Participation: Optimising Outcomes in Childhood-Onset Neurodisability. Mac Keith Press, 2020.

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12

Bryan, Lask, and Bryant-Waugh Rachel, eds. Childhood onset anorexia nervosa and related eating disorders. Hove (UK): Lawrence Erlbaum Associates, 1993.

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13

Childhood onset of "adult" psychopathology: Clinical and research advances. Washington, DC: American Psychiatric Press, 2000.

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14

Childhood Onset Of Anorexia Nervosa And Related Eating Disorders. Lawrence Erlbaum Associates, 1993.

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15

Persistence, Onset, Risk Factors and Outcomes of Childhood Mental Disorders. Palgrave Macmillan, 2003.

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16

Muscular dystrophy sourcebook: Basic consumer information about congenital, childhood-onset, and adult-onset forms of muscular dystrophy ... Detroit, MI: Omnigraphics, Inc., 2004.

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17

Hanas, Ragnar, Andrea Scaramuzza, and Carine de Beaufort. Research into Childhood-Onset Diabetes: From Study Design to Improved Management. Springer, 2016.

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18

Hanas, Ragnar, Andrea Scaramuzza, and Carine de Beaufort. Research into Childhood-Onset Diabetes: From Study Design to Improved Management. Springer, 2018.

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19

Participation and Well Being Among Children and Youth With Childhood Onset Disabilities. MDPI, 2021. http://dx.doi.org/10.3390/books978-3-0365-1443-7.

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20

The comparison of obstetric complication histories of individuals with childhood-onset schizophrenia vs. adult-onset schizophrenia: A multi-site feasibility study. Ottawa: National Library of Canada, 1999.

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21

Strauss, John. Molecular genetic investigation of brain-derived neurotrophic factor in childhood-onset mood disorder. 2005.

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22

Rapoport, Judith L. Childhood Onset of "Adult" Psychopathology: Clinical and Research Advances (American Psychopathological Association Series). American Psychiatric Publishing, Inc., 2000.

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23

Strauss, John. Molecular genetic investigation of brain-derived neurotrophic factor in childhood-onset mood disorder. 2005.

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24

Walsh, Kelda H., and Christopher J. McDougle. Impulsivity in Childhood. Edited by Jon E. Grant and Marc N. Potenza. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195389715.013.0130.

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This chapter discusses impulse control disorders in children 12 years of age and younger. In this age group, the available research focuses on fire setting/pyromania, trichotillomania, and pathological gambling. Less well studied are kleptomania, intermittent explosive disorder, and the impulse control disorder not otherwise specified, pathological skin picking. Clinical presentation, diagnosis, epidemiology, age of onset, risk factors, sociocultural factors, and comorbidity will be reviewed. Psychotherapeutic interventions for the age group will be explored, with particular emphasis on behavioral therapy. The available literature on psychopharmacological treatments, particularly selective serotonin reuptake inhibitors and opioid antagonists, will also be explored.
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25

Jimerson, Shane R., Huijun Li, and Melissa Pearrow. Identifying, Assessing, and Treating Early Onset Schizophrenia at School. Springer, 2012.

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26

Staedtke, Verena, and Eric H. Kossoff. Epilepsy Syndromes in Childhood. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0074.

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Epilepsy syndromes of childhood are a heterogeneous group of disorders that occur at specific neurodevelopmental stages, with a variable prognosis ranging from benign to catastrophic. In clinical practice they are categorized based on seizure type, age of onset, clinical presentation, electroencephalographic (EEG) findings, as well as response to treatment. In addition, recent advancements in neuroimaging and genetic testing have become important diagnostic tools revealing underlying defects for some of these syndromes. This knowledge has consequences for clinical practice, as it opens new perspectives for early diagnosis, prognosis and treatment. Here, we provide an up-to-date overview of the most common pediatric epilepsy syndromes, their clinical findings, associated EEG findings, and clinical management.
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27

Zanarini, Mary C., and Lindsey C. Conkey. Onset, Course, and Prognosis for Borderline Personality Disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199997510.003.0003.

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Borderline personality disorder (BPD) is a common psychiatric disorder; the best epidemiological evidence estimating that about 2% of American adults meet DSM-IV criteria for BPD and an estimated 19% of psychiatric inpatients and approximately 11% of psychiatric outpatients meet criteria for BPD. Cross-sectional studies have found that BPD is associated with high levels of mental health service utilization and a serious degree of psychosocial impairment These facts suggest that BPD is a serious public health problem and yet, the course of BPD has received relatively little attention. Most studies have used adult samples (people age 18 or older), and clinicians have been reluctant until very recently to diagnose adolescents or latency-aged children as meeting full-blown criteria for BPD, choosing instead to diagnose disruptive mood dysregulation disorder (DMDD)—a disorder of childhood marked by frequent temper outbursts and chronic anger or irritability.
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28

Shannon, Joyce Brennfleck. Muscular Dystrophy Sourcebook: Basic Consumer Health Information About Congenital, Childhood-Onset, and Adult-Onset Forms of Muscular Dystrophy, Such as ... Becker, Emery-Drei (Health Reference Series). Omnigraphics, 2004.

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29

James, Anthony. Depressive Disorders in Childhood and Adolescence. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801900.003.0008.

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This chapter focuses on depressive disorders in childhood and adolescence. Depression in children and adolescents is a complex and debilitating disease, and typically has a lifelong, chronic, and recurrent course. The peak age of onset of depression is between 13 and 15 years. After providing a clinical picture of depression, this chapter discusses early childhood depression and differential diagnosis, including paediatric bipolar disorder, psychotic depression and seasonal affective disorder, oppositional and conduct disorder, and substance misuse and medical conditions. It then examines comorbidity, paying attention to bipolar disorder and suicidal behaviour, along with the assessment and prevention of depression. It also considers some of the determinants of depression, such as stress, trauma, life events, and biological factors such as genetics, brain mechanisms, hormones, and resilience. Finally, it describes treatment options for childhood and adolescent depression.
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30

The COBAD Syndrome: New Hope for People Suffering from the Inherited Syndrome of Childhood-Onset Bipolar Disorder with ADHD. AuthorHouse, 2005.

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31

Reuben, Julia, and Daniel S. Shaw. Parental Depression and the Development of Coercion in Early Childhood. Edited by Thomas J. Dishion and James Snyder. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199324552.013.7.

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One of the driving theories of the development of child antisocial behavior is Patterson’s model of parent-child coercion. Although Patterson hypothesized that coercive processes are established beginning in early childhood, few studies have sought to understand its developmental precursors in early childhood. Even fewer studies have attempted to examine factors that might compromise parenting quality and lead to coercive parent-child interactions during early childhood. One factor repeatedly shown to compromise parenting quality is parental depression. As such, this chapter focuses on how depression among mothers and alternative caregivers, including fathers, is associated with the early onset of coercive family dynamics. The results of the current study have implications for understanding the genesis of coercive processes and for the design of early prevention programs, affirming the importance of including maternal depression in our prevention models.
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32

Bloch, Michael H. Natural History and Long-Term Outcome of OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0005.

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Obsessive-compulsive disorder (OCD) is often a chronic condition. Convergent evidence suggests that early-onset and adult-onset disease are importantly distinct: early-onset OCD is more highly genetic, has a male bias, and is more often associated with tic disorders and attention deficit disorder. Adult-onset OCD has an equal male–female ratio and is more often associated with anxiety and depression. Long-term follow-up studies from before institution of effective treatments suggest that a minority of individuals with adult-onset OCD remit, and many have persistent severe symptoms. There are few analogous studies of patients with childhood-onset OCD. Prognosis has improved over the past 30 years with the development of effective, evidence-based pharmacotherapy and psychotherapies. More recent long-term follow-up studies of both adult-onset and pediatric-onset OCD suggest remission rates of up to 50%. Refractory illness nevertheless remains an important clinical problem.
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33

Rahman, Shamima, and Mirian C. H. Janssen. Coenzyme Q10 Deficiency. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0011.

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Primary CoQ10 deficiencies are usually diagnosed in childhood, but late-onset forms are recognized. The expression of all clinical symptoms is extremely variable, but six major phenotypes are recognized: (1) encephalomyopathy, seizures, and ataxia; (2) infantile-onset multisystem disease; (3) cerebellar ataxia; (4) isolated myopathy; (5) Leigh syndrome; and (6) isolated nephrotic syndrome. Early treatment with exogenous CoQ10 supplementation may result in a good outcome.
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34

Glasper, Edward Alan, Gillian McEwing, and Jim Richardson, eds. Endocrine and metabolic disorders. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780198569572.003.0019.

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The endocrine system: related anatomy and physiology 632Type 1 diabetes mellitus in childhood and adolescence 634Diabetic ketoacidosis (DKA) 636Management of DKA 638Type 2 diabetes mellitus 640Maturity-onset diabetes mellitus of the young (MODY) 642Hypothyroidism 644Short stature 646Tall stature ...
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35

Murphy, Claire Louise, Yiannis Ioannou, and Nicola Ambrose. Juvenile systemic lupus erythematosus. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198739180.003.0008.

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Juvenile-onset systemic lupus erythematosus (JSLE) is similar to adult-onset SLE, but there are distinct differences in clinical features, serology, and management requirements. It is more aggressive than adult-onset SLE with frequent renal and haematological manifestations and higher mortality rates. The cause of JSLE is unknown but appears to be multifactorial with genetic, immunological, hormonal, and environmental influences. Macrophage activation syndrome is a potentially life-threatening complication, and may mimic the underlying disease or be confused with sepsis. Transferring care from paediatric to adult care can be a difficult milestone and should be tailored to the individual patient. Management requires a multisystemic, holistic approach with recognition of psychosocial factors that occur during normal childhood and adolescence. International collaboration and further research is needed to optimize care for these patients.
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36

Prasad, Supritha, and Edwin H. Cook. Novel Approaches for Treating Pediatric Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0067.

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Multifactorial mechanisms, including varying degrees of polygenic risk, contribute to most child onset psychiatric disorders. Methods to better understand the biological impact of inherited low-risk variation are emerging, and these studies may be useful to develop novel treatments for childhood onset psychiatric disorders. In some neurodevelopmental disorders, specifically autism spectrum disorder (ASD) and intellectual disability (ID), recurrent spontaneously mutated genes have been identified. This leads to the current focus on individual, high-risk targets (e.g., SHANK3, FMR1, MECP2, CHD8) for development of novel treatments. This chapter summarizes and begins to compare neurobiological data from several distinct single gene disorders as a means to guide further therapeutic development based on overlapping pathways of interest.
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37

Hesdorffer, Dale C. Epidemiology of Epilepsy. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0042.

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Epilepsy affects 1 out of every 26 people during their lifetime. Worldwide, the incidence of epilepsy ranges from 28.0/100,000 to 235.5/100,000, with the large variation attributable to differences in methodology across studies. The prevalence of active epilepsy provides important information about the burden of epilepsy in the population and spurs public health planner to assess the needs of the epilepsy population. The active prevalence of epilepsy ranges from 2.4/1,000 to 22.8/1,000 worldwide and more than 65 million people have active epilepsy. Risk factors for childhood-onset and adult-onset epilepsy are discussed, considering epilepsy etiologies (e.g., severe traumatic brain injury), newer risk factors without bidirectional relationships with epilepsy (e.g., low socioeconomic status), risk factors with bidirectional relationships (e.g., psychiatric disorders), and different types of acute symptomatic seizures (e.g., febrile seizures).
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38

Moore, Jane M. Energy need, nutrient intake, fitness, body composition, and health risk factors in women with childhood and adult-onset obesity before and after a 9-month nutrition education and walking program. 1988.

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39

Tillema, Jan-Mendelt, J. Graves, L. A. Benson, G. S. Aaen, A. Belman, J. Parrish, B. Weinstock-Guttman, L. Krupp, T. Chitnis, and E. Wauban. Pediatric Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0022.

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Increased interest in pediatric-onset multiple sclerosis (MS) has contributed to improved knowledge of the presentation and evolution of central nervous system demyelinating diseases in childhood. This chapter reviews the unique features and challenges related to pediatric MS. The close proximity of pediatric MS to the biological onset of the disease provides a unique window into disease pathogenesis at stages of life when innate and adaptive immune pathways are still maturing. It is expected that the interplay between genetics, epigenetics, environmental exposures, and the maturing central nervous system in children with MS will provide important insights into the earliest phases of the disease. This chapter reviews the unique features that distinguish pediatric patients with MS from their adult counterparts. Specific emphasis is placed on the work-up and management of these patients in the context of current knowledge.
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40

Tuschl, Karin, Peter T. Clayton, and Philippa B. Mills. Disorders of Manganese Metabolism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0045.

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Manganese is an essential trace metal for numerous metalloenzymes. Manganese homeostasis requires tight regulation in vivo and disruption of this balance can lead to manganese overload and subsequent accumulation of manganese in brain, liver, and blood. Mutations in SLC30A10, a cell surface-localized manganese efflux transporter, cause an autosomal recessive hypermanganesemia syndrome with two distinct phenotypes: childhood onset dystonia and adult onset Parkinsonism, associated with chronic liver disease, polycythemia and features of iron depletion. MRI brain appearances are characteristic of Mn deposition with hyperintense basal ganglia on T1-weighted images. Chelation therapy with disodium calcium edetate and iron supplementation effectively lower blood manganese levels, halt liver disease progression and improve neurological symptoms.The inherited form of hypermanganesemia can be distinguished from acquired causes of manganese overload including environmental overexposure and acquired hepatocerebral degeneration in cases of end stage liver disease.
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41

Ginsberg, Rachel E., Samantha Morrison, and Anthony Puliafico. Pediatric OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0003.

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This chapter outlines the clinical presentation and course of pediatric OCD, discusses its etiology and phenomenology, and describes principal assessment methods for evaluation of symptoms. Obsessive-compulsive disorder (OCD) often manifests during childhood and adolescence. Symptom presentation in children is similar to that in adults and is typically characterized by the presence of both obsessions and compulsions. Pediatric OCD is highly comorbid with other psychiatric disorders, and evidence suggests abnormal brain functioning in youth with OCD. The onset and progression of OCD in childhood have developmental implications, given the associated distress and interference with academic, social, and home functioning. Multiinformant and multidiagnostic evaluation, including administration of evidence-based semistructured clinical interviews and rating scales, is optimal.
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42

Nguyen, Kim-Phuong, and Chris D. Glover. Obesity. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0043.

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Childhood obesity has become a major public health concern. Obesity affects perioperative anesthetic management from airway management and drug selection to postoperative monitoring requirements. This chapter explains the perioperative implications of childhood obesity and addresses multiple considerations in the formulation of an anesthetic plan for the obese child. The chapter examines the anesthetic implications of obesity and its effects on various body systems, discusses the principles of perioperative management of obese children, and grants a working knowledge of pharmacokinetics of common anesthetic drugs in obese children and dosage implications. A case study of an obese 13-year-old boy with late-onset Blount disease who presents for proximal tibial osteotomy with internal fixation is presented to illustrate the concepts in the chapter.
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43

Dietz, Laura J., Jennifer Silk, and Marlissa Amole. Depressive Disorders. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.19.

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Depressive disorders onset early in development. Depression during childhood and adolescence is associated with serious disruptions in emotional, social, and occupational functioning into adulthood and a high likelihood of recurrence. This chapter discusses clinical manifestations, prevalence, and course of depression presenting in early childhood (ages 3–6), middle childhood/preadolescence (ages 7–12), and adolescence (13–18). An overview is presented of standardized interviews and questionnaires for clinical assessment of depression in children and adolescents; the chapter summarizes research on empirically supported treatments for youth depression. Also included is a case study of a depressed adolescent with treatment plans formulated from both cognitive behavior therapy and interpersonal psychotherapy perspectives. Future directions for research on depressive disorders in youths are discussed, including neuroimaging research using ecologically valid stimuli, empirically supported interventions for younger children and preadolescents, and personalization of psychosocial treatment to youth’s profiles of risk and protective factors to increase effectiveness.
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44

Davis, Donald R. Children. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198702603.003.0012.

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Classical Hindu law distinguishes the childhood, youth, and adulthood of male children in terms of ritual and legal eligibility and duty. Childhood is marked both by freedom from the constraints and obligations of ritual and law and by ritual ineligibility and legal incapacity. The consecratory rite of the sacred thread marks a son’s eligibility and obligation for religious study and ritual. Youth is the period of religious training that culminates in the completion of studies and in marriage. Legal majority is recognized for sons at age sixteen, while full ritual rights and duties commence only with marriage. In the classical texts, the onset of menstruation marks a daughter’s eligibility to marry, though her legal capacity remains restricted in principle. Daughters thus figure prominently in the intricate negotiations of marriage, kinship, and family reputation.
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45

Ferreira, Isabel, and Jos WR Twisk. Physical activity, cardiorespiratory fitness, and cardiovascular health. Edited by Neil Armstrong and Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0017.

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It is now recognized that cardiovascular disease (CVD) is partly a paediatric problem, i.e. the onset begins in childhood, although clinical symptoms may not become apparent until later in life. Therefore, from a primary prevention point of view, the extent to which physical activity or physical fitness in childhood may deter this process is of utmost importance. Although physical activity and CRF at a young age have not been directly linked to the incidence of CVD, evidence thus far supports cardiovascular health benefits of early higher physical activity and CRF levels on cardiometabolic risk factors like obesity, blood pressure, insulin resistance, and their maintenance throughout the course of life. By affecting these intermediary pathways, lifelong (high-intensity) physical activity may also deter the age-related decreases in CRF and related signs of premature arterial ageing.
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46

Drapeau, Elodie, Hala Harony-Nicolas, and Jacqueline N. Crawley. Animal and Cellular Models of Pediatric Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0061.

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The study of childhood psychiatric disorders is especially challenging, not only because of the difficulties in obtaining relevant human samples but also because of ethical considerations regarding the ability of children to provide informed consent. Models that can be experimentally manipulated are therefore indispensable to study those disorders. Traditionally, biological psychiatry research has extensively employed animal models and characterizations of rodent behavior. More recently, induced pluripotent stem cells (iPSCs), and induced differentiation of iPSCs into different types of brain cells have offered new alternative strategies to elucidate mechanisms underlying cellular processes. Regardless of how they are created, optimal models should demonstrate face validity, construct validity, and predictive validity to be considered most relevant. This chapter highlights the major animal and cellular models currently used in the research of childhood-onset psychiatric disorders.
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47

Introne, Wendy J. Alkaptonuria. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0015.

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Alkaptonuria is an autosomal recessive disorder with an incidence of 1:250,000 to 1:500,000. Aside from urine that darkens, the disease is relatively asymptomatic in childhood. As a result, the diagnosis is often overlooked early in life and not considered in many patients until they begin to manifest symptoms as adults. Features include pigment deposition (ochronosis) on the eyes, ears, and hands; early-onset, progressive arthritis, particularly of the spine and large joints; valvular heart disease; and renal and prostate stones. Management continues to be symptomatic, but specific treatment with nitisinone appears promising with additional clinical trials being planned.
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48

Castriotta, Natalie, and Michelle G. Craske. Depression and Comorbidity with Panic Disorder. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.027.

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Comorbidity between panic disorder and major depression is found in the majority of individuals with panic disorder and a substantial minority of individuals with major depression. Comorbidity between panic disorder and depression is associated with substantially more severe symptoms of each of the disorders, greater persistence of each disorder, more frequent hospitalization and help-seeking behavior, more severe occupational impacts, and a significantly higher rate of suicide attempts. These two disorders share many risk factors, such as neuroticism, exposure to childhood abuse, informational processing biases, and elevated amygdala activation in response to negative facial expressions. Research on the temporal priority of panic disorder and major depression has most frequently found that panic attacks and other symptoms of anxiety predate the onset of the first major depressive episode, but the first depressive episode predates the onset of full panic disorder. Treatment studies indicate that cognitive behavioral therapy (CBT) is the most effective treatment for panic disorder. Other forms of treatment include medication, particularly selective serotonin reuptake inhibitors. Comorbid depression does not appear to affect the outcome of CBT for a principal diagnosis of panic disorder, and CBT for panic disorder has positive, yet limited, effects on symptoms of depression.
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49

Phillips, Katharine A. Body Dysmorphic Disorder in Children and Adolescents. Edited by Katharine A. Phillips. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190254131.003.0014.

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Body dysmorphic disorder (BDD) usually has its onset during childhood or adolescence. Prevalence studies indicate that BDD is common in adolescents. BDD symptoms in children and adolescents appear largely similar to those in adults, although BDD may be somewhat more severe in youth. Youth with BDD typically have poor psychosocial functioning and mental health–related quality of life. BDD often causes academic underachievement, social avoidance, and other types of psychosocial impairment; it may lead to school refusal and dropping out of school. Suicidal ideation and attempts, physical aggression behavior that is attributable to BDD symptoms, and substance use disorders are common risk behaviors in youth with BDD. BDD can derail the developmental trajectory, which makes appropriate treatment especially important during childhood and adolescence. Youth in mental health settings and cosmetic treatment settings, as well as youth who express suicidal ideation or have attempted suicide, should be screened for BDD.
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50

De Rubeis, Silvia, Kathryn Roeder, and Bernie Devlin. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0062.

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The development of the human brain is a complex process that begins during the first weeks of gestation and extends at least through adolescence and early adulthood. This chapter will review the perturbations of the developmental trajectories during prenatal and early postnatal life that can lead to psychiatric disorders of childhood onset. We will provide a general view of the epochs and trajectories of brain development, from embryonic neurulation to postnatal development, with an emphasis on the development of the neocortex. Within each developmental window, we will consider some salient cellular and molecular pathways, and discuss how genetic and environmental insults underlying psychiatric disorders disrupt them.
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