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Journal articles on the topic 'Chikungunya'

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Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Gómez Alba, Virgen, Maylen Chalas, and Eduardo Michelen. "Epidermolisis por chikungunya por transmisión autóctona en República Dominicana. Caso atípico y severo en un recién nacido (RN)." Ciencia y Salud 4, no. 1 (March 3, 2020): 71–78. http://dx.doi.org/10.22206/cysa.2020.v4i1.pp71-78.

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Introducción: chikunguya, enfermedad transmitida por la picadura del mosquito del género Aedes, suele ser asin-tomática y benigna en su evolución. Sin embargo, se han observado manifestaciones clínicas atípicas y severas en niños durante la infección por chikungunya. Objetivo: presentar caso epidermólisis por chikungunya en RN de 24 días de edad durante la epidemia del 2014 en República Dominicana. Caso clínico: RN de 27 días de edad con lesión inicial ampollosa en tórax que luego se generalizó correspondiendo a una epidermólisis. Se observó una buena evolución y lesiones residuales híper e hipocrómicas en piel.

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2

NAYAK, KAUSTUV, Vineet Jain, Manpreet Kaur, Naushad Khan, Ramesh Chandra Rai, Kritika Dixit, Rohit Sagar, et al. "Human immunity to chikungunya infection." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 249.3. http://dx.doi.org/10.4049/jimmunol.204.supp.249.3.

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Abstract Chikungunyna virus is expanding globally and continue to cause major public health threat to Indian populations. Vaccine efforts are underway, and it is hoped that these will eventually progress to human evaluation. However, currently we have little understanding of the phenotypes and functions of the human T cells in chikungunya patients, a knowledge that is essential for improving vaccine design/testing and evaluation efforts. Here, we provide a detailed analysis of the CD8 T cell responses in chikungunya patients from India. We found that CD38+ HLADR+ CD8 T cell subset expanded dramatically in chikungunya febrile patients with frequencies averaging about 20% of the total CD8 T cells, and reaching as high as 50% of the CD8 T cells in some patients. The frequencies of these activated CD8 T cells were substantially low and barely above background levels in afebrile patients reporting to the clinic with persistent arthralgia/arthritis that was lasting for more than 30 days. These massively expanding CD8 T cells observed in the acute febrile patients were highly proliferating (KI67 ), robustly expressing markers indicative strong Th1 differentiation (T-bet), cytotoxic functions (Perforin) and inflammatory/synovial tissue homing characteristics (CX3CR1 and CXCR4). Interestingly, antigen-stimulation mediated IFN-g producing functions of these cells was highly compromized, reminiscent of the “cytokine stunned” phenotype. Taken together, these results suggest that these highly differentiated effector CD8 T cell that were massively expanding during acute chikungunya febrile infection might be involved in protection by homing to infected tissues and eliminating infected targets rather than causing inflammation.

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3

Burnett, Mark W. "Chikungunya." Journal of Special Operations Medicine 14, no. 4 (2014): 129. http://dx.doi.org/10.55460/8h36-wo5p.

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4

Rodriguez-Cintron, William. "Chikungunya." Annals of Internal Medicine 162, no. 7 (April 7, 2015): 531. http://dx.doi.org/10.7326/l15-5076.

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5

Al-Araimi, Tariq, and Shikha Mittoo. "Chikungunya." Annals of Internal Medicine 162, no. 7 (April 7, 2015): 531. http://dx.doi.org/10.7326/l15-5076-2.

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6

Hamer, Davidson H., and Lin H. Chen. "Chikungunya." Annals of Internal Medicine 162, no. 7 (April 7, 2015): 532. http://dx.doi.org/10.7326/l15-5076-3.

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7

HORWOOD, P. F., and P. BUCHY. "Chikungunya." Revue Scientifique et Technique de l'OIE 34, no. 2 (August 1, 2015): 479–89. http://dx.doi.org/10.20506/rst.34.2.2373.

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8

Anadarajah, Cholan. "Chikungunya." London Student Journal of Medicine 1, no. 1 (June 15, 2009): 66–67. http://dx.doi.org/10.4201/lsjm.gch.001.

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9

Amin, Md Robed, Md Mujibur Rahman, and Quazi Tarikul Islam. "Chikungunya." Journal of Medicine 18, no. 2 (August 24, 2017): 92–108. http://dx.doi.org/10.3329/jom.v18i2.33687.

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10

Powers, Ann M. "Chikungunya." Clinics in Laboratory Medicine 30, no. 1 (March 2010): 209–19. http://dx.doi.org/10.1016/j.cll.2009.10.003.

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11

Epidemiologist, Chief. "Chikungunya." Journal of the College of Community Physicians of Sri Lanka 11, no. 2 (December 20, 2010): 27. http://dx.doi.org/10.4038/jccpsl.v11i2.8261.

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12

MacFadden, D. R., and I. I. Bogoch. "Chikungunya." Canadian Medical Association Journal 186, no. 10 (June 9, 2014): 775. http://dx.doi.org/10.1503/cmaj.140031.

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13

Vairo, Francesco, Najmul Haider, Richard Kock, Francine Ntoumi, Giuseppe Ippolito, and Alimuddin Zumla. "Chikungunya." Infectious Disease Clinics of North America 33, no. 4 (December 2019): 1003–25. http://dx.doi.org/10.1016/j.idc.2019.08.006.

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14

Stamm, Lola V. "Chikungunya." JAMA Dermatology 151, no. 3 (March 1, 2015): 257. http://dx.doi.org/10.1001/jamadermatol.2014.2034.

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15

Castillo Ocampos, Erika Belén, Carlos Rubén Perdomo Paredes, Amanda Gabriel Roa Colman, Ramón Abundio Silva Jara, Bruno Marcelo Ortellado Garrido, Myrian Monserratt Grance Meza, Luz María Cabrera Yudis, María Eugenia Acosta de Hetter, and Laura Aria Zayas. "Tratamiento de las manifestaciones articulares en fase crónica de la fiebre chikungunya." Revista Paraguaya de Reumatología 9, no. 2 (December 30, 2023): 64–70. http://dx.doi.org/10.18004/rpr/2023.09.02.64.

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La fiebre Chikungunya es causada por un arbovirus ARN perteneciente a la familia Togaviridae del género alphavirus, llamado “virus del chikungunya”, este virus tiene como vector el Aedes aegypti y el Aedes albopictus. En su fase aguda la enfermedad se manifiesta por fiebre, artritis o artralgias severas, mialgias, cefalea, fotofobia, linfadenopatías y brotes cutáneos, los síntomas pueden progresar a una fase subaguda hasta crónica, donde persisten las manifestaciones articulares y la fatiga. Se realizó una revisión sistemática en las bases de PubMed, Cochrane, Dovepress y SciELO, utilizando las palabras claves: chikungunya y chikunguña, cruzadas con las palabras: artritis crónica y tratamiento. Se incluyeron en el estudio un total de 16 artículos, 6 artículos de revisión, 4 artículos originales, 2 ensayos clínicos, 2 reportes de caso, 1 revisión sistemática y 1 carta al editor. Entre las opciones farmacológicas, el metotrexato es el fármaco más estudiado y compite con los efectos de los AINE. Como terapias no farmacológicas se encuentran la fisioterapia y la terapia física, utilizados como complementos a la terapia farmacológica. El uso de terapias caseras, incluso la homeopatía, también podrían agregarse, atendiendo principalmente el factor psíquico y cultural de los pacientes.

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16

Pathak, Santosh, Nagendra Chaudhary, Prativa Dhakal, Sanjay Ray Yadav, Binod Kumar Gupta, and Om Prakash Kurmi. "Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal." International Journal of Pediatrics 2021 (April 20, 2021): 1–6. http://dx.doi.org/10.1155/2021/6613564.

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Objectives. Chikungunya and scrub typhus infection are important causes of undifferentiated fever in tropical zones. The clinical manifestations in both conditions are nonspecific and often overlap. This study compares the clinical manifestations and the outcome of chikungunya with chikungunya-scrub typhus coinfection in children. Methods. A hospital-based observational study was conducted in children below 15 years of age over 16-month duration in 2017-2018. Chikungunya was diagnosed by IgM ELISA. All positive chikungunya cases were subjected to scrub typhus testing, dengue testing, leptospira testing, and malaria testing. Clinical manifestations and outcomes of all patients were recorded. Results. Out of the 382 admitted cases with fever, 11% ( n = 42 ) were diagnosed with chikungunya, and the majority ( n = 30 , 71.4%) were male. Among the 42 chikungunya cases, 17 (40.5%) tested positive for scrub typhus and one positive for falciparum malaria. Out of a total of 42 chikungunya cases, myalgia, nausea/vomiting, headache, abdominal pain, lymphadenopathy, hepatomegaly, splenomegaly, and edema were 81%, 73.8%, 66.7%, 64.3%, 59.5%, 52.4%, 40.5%, and 38.1%, respectively. Besides, altered sensorium (31%), jaundice (26.2%), dry cough (21.4%), shortness of breath (19%), and seizures (16.7%) were other clinical manifestations present in this group of children. Patients with chikungunya-scrub typhus coinfection reported headaches, pain in the abdomen, dry cough, shortness of breath, seizures, and splenomegaly, significantly more ( p value < 0.05) compared to those with chikungunya only. Thirteen (31%) children developed shock, five in the chikungunya group and eight in the chikungunya-scrub typhus coinfection group. Six children in the coinfection group received inotrope. Among the chikungunya-only cases, 22 recovered and one died, whereas in the chikungunya-scrub typhus coinfection group, fourteen recovered and three died. Conclusions. Both the chikungunya and scrub typhus coinfection groups shared many similar clinical manifestations. In children, coinfection with scrub typhus often leads to modification of the clinical profile, complications, and chikungunya outcome.

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17

Gopakumar, Hariharan, and Sivji Ramachandran. "Congenital chikungunya." Journal of Clinical Neonatology 1, no. 3 (2012): 155. http://dx.doi.org/10.4103/2249-4847.101704.

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18

Pathak, Himanshu, Mithun C. Mohan, and Vinod Ravindran. "Chikungunya arthritis." Clinical Medicine 19, no. 5 (September 2019): 381–85. http://dx.doi.org/10.7861/clinmed.2019-0035.

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19

Azad, Khan Abdul Kalam. "Chikungunya Fever." Journal of Dhaka Medical College 21, no. 2 (June 14, 2013): 129–30. http://dx.doi.org/10.3329/jdmc.v21i2.15298.

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20

Quintanilla, Sergio Daniel, and Emilio Barruetos. "Fiebre Chikungunya." Acta Pediátrica Hondureña 5, no. 1-2 (December 8, 2015): 371–77. http://dx.doi.org/10.5377/pediatrica.v5i1-2.2260.

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Antecedentes: La fiebre Chikungunya es causada por un alfavirus (CHIKV) ARN perteneciente a la familia Togaviridae. Fue descrito en 1953, a partir de entonces se han presentado epidemias desde África, Asia y últimamente casos en las Antillas en América. Ante el riesgo de importación y transmisión del virus, esta entidad ha adquirido importancia, antes poco conocida en nuestro continente. La presente revisión bibliográfica tiene como objetivo la actualización de conocimientos acerca de la fiebre Chikungunya. El CHIKV es transmitido por dos vectores, Aedes aegypti y albopictus, los humanos son el reservorio principal en los periodos epidémicos. Después de 3 a 7 días de incubación, aparece la fiebre, artralgias, cefalea. Laboratorialmente, se observa trombocitopenia leve, leucopenia con linfopenia. Los individuos no infectados previamente están en riesgo de adquirir la infección y desarrollar la enfermedad, siendo los neonatos y los ancianos más propensos a desarrollar formas más graves. La transmisión de madre a hijo es frecuente en la viremia materna intraparto, y conduce a la infección. La mortalidad es baja, pero la artralgia inflamatoria con artropatía/artritis destructiva puede comprometer la calidad de vida del paciente afectado. Dada la introducción del CHIKV en la Región, la detección oportuna, una respuesta apropiada y rápida, son necesarias para minimizar el riesgo de importación y transmisión del CHIKV.Acta Pediátrica Hondureña, Vol. 5, No. 1 y 2 / Abril 2014 a Marzo 2015: 371-377

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21

Simon, Fabrice, Philippe Parola, Marc Grandadam, Sabrina Fourcade, Manuela Oliver, Philippe Brouqui, Pierre Hance, et al. "Chikungunya Infection." Medicine 86, no. 3 (May 2007): 123–37. http://dx.doi.org/10.1097/md/0b013e31806010a5.

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22

Abraham, George M. "Chikungunya Virus." Infectious Diseases in Clinical Practice 27, no. 2 (March 2019): 67. http://dx.doi.org/10.1097/ipc.0000000000000706.

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23

Cinti, Sandro. "Chikungunya Fever." Infectious Diseases in Clinical Practice 17, no. 1 (January 2009): 6–11. http://dx.doi.org/10.1097/ipc.0b013e31818a15e5.

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24

Islam, Quazi Tarikul. "Chikungunya Fever." Journal of Medicine 18, no. 2 (August 24, 2017): 54–55. http://dx.doi.org/10.3329/jom.v18i2.33677.

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25

Phillips, Jennan A. "Chikungunya Virus." Workplace Health & Safety 63, no. 6 (June 2015): 280. http://dx.doi.org/10.1177/2165079915591290.

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26

Mourya, DT, and AC Mishra. "Chikungunya fever." Lancet 368, no. 9531 (July 2006): 186–87. http://dx.doi.org/10.1016/s0140-6736(06)69017-x.

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27

Yazdani, R., and V. V. Kaushik. "Chikungunya fever." Rheumatology 46, no. 7 (May 9, 2007): 1214–15. http://dx.doi.org/10.1093/rheumatology/kem059.

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28

Krishnamurthy, V. "Chikungunya arthritis." Indian Journal of Rheumatology 3, no. 3 (September 2008): 91–92. http://dx.doi.org/10.1016/s0973-3698(10)60124-0.

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29

Vu, David M., Donald Jungkind, and Angelle Desiree LaBeaud. "Chikungunya Virus." Clinics in Laboratory Medicine 37, no. 2 (June 2017): 371–82. http://dx.doi.org/10.1016/j.cll.2017.01.008.

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30

Kucharz, Eugene J., and Ilona Cebula-Byrska. "Chikungunya fever." European Journal of Internal Medicine 23, no. 4 (June 2012): 325–29. http://dx.doi.org/10.1016/j.ejim.2012.01.009.

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31

Gerber, A., and D. Klingelhoefer. "Chikungunya-Fieber." Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie 64, no. 4 (June 14, 2014): 281–82. http://dx.doi.org/10.1007/s40664-014-0042-4.

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32

Petersen, Lyle R., and Ann M. Powers. "Chikungunya: epidemiology." F1000Research 5 (January 19, 2016): 82. http://dx.doi.org/10.12688/f1000research.7171.1.

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Chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. Joint pains may last months or years. It is vectored primarily by the tropical and sub-tropical mosquito, Aedes aegypti, but is also found to be transmitted by Aedes albopictus, a mosquito species that can also be found in more temperate climates. In recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the tropical and sub-tropical world and, as such, has also become a frequent cause of travel-associated febrile illness. In this review, we discuss our current understanding of the biological and sociological underpinnings of its emergence and its future global outlook.

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33

Lucas, GN. "Chikungunya fever." Sri Lanka Journal of Child Health 36, no. 1 (September 23, 2008): 3. http://dx.doi.org/10.4038/sljch.v36i1.38.

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34

Dotters-Katz, Sarah K., Matthew R. Grace, Robert A. Strauss, Nancy Chescheir, and Jeffrey A. Kuller. "Chikungunya Fever." Obstetrical & Gynecological Survey 70, no. 7 (July 2015): 453–57. http://dx.doi.org/10.1097/ogx.0000000000000184.

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35

Stephenson, Joan. "Chikungunya Fever." JAMA 298, no. 15 (October 17, 2007): 1752. http://dx.doi.org/10.1001/jama.298.15.1752-a.

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36

Stephenson, Joan. "Chikungunya Virus." JAMA 298, no. 23 (December 19, 2007): 2733. http://dx.doi.org/10.1001/jama.298.23.2733-d.

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37

Carina, Annisa', Sauqi Futaqi, Carly Marshanda Arta M, Ita Purnama Sari, and Abdul Ghofur. "Penyuluhan Bahaya Chikungunya di Desa Purwokerto, Kecamatan Ngimbang, Kabupaten Lamongan." I-Com: Indonesian Community Journal 3, no. 3 (September 6, 2023): 1166–74. http://dx.doi.org/10.33379/icom.v3i3.2983.

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Chikungunya adalah penyakit yang disebabkan oleh virus Chikungunya (CHIKV) yang ditandai dengan gejala demam tinggi dan nyeri sendi yang sangat parah. Kasus chikungunya yang terjadi pertama kali di Indonesia adalah di Kota Samarinda tahun 1973 dan tercatat menjadi KLB (Kejadian Luar Biasa), kemudian kasus tersebut hilang selama kurang lebih 20 tahun setelah itu mulai muncul lagi di tahun 2001 di Sumatera yang juga tercatat sebagai KLB. Tercatat kasus chikungunya di tahun 2001-2003 mencapai 3.918 total kasus tanpa kematian. Penyuluhan ini bertujuan untuk mengetahui seberapa besar tingkat kematian yang diakibatkan oleh virus Chikungunya (CHIKV) dan mengetahui cara pencegahan dan pengobatan virus Chikungunya, khususnya di Desa Purwokerto, Kecamatan Ngimbang, Kabupaten Lamongan. Metode yang digunakan adalah melakukan pengumpulan data melalui studi pustaka, survei kondisi lapangan dan penyuluhan terkait chikungunya. Dari hasil penyuluhan chikungunya didapat hasil positif yaitu meningkatnya pengetahuan masyarakat terkait penyakit chikungunya seperti gejala, cara pencegahan dan pengobatannya.

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38

Hakim, Mohamad S., and Abu T. Aman. "Understanding the Biology and Immune Pathogenesis of Chikungunya Virus Infection for Diagnostic and Vaccine Development." Viruses 15, no. 1 (December 23, 2022): 48. http://dx.doi.org/10.3390/v15010048.

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Chikungunya virus, the causative agent of chikungunya fever, is generally characterized by the sudden onset of symptoms, including fever, rash, myalgia, and headache. In some patients, acute chikungunya virus infection progresses to severe and chronic arthralgia that persists for years. Chikungunya infection is more commonly identified in tropical and subtropical regions. However, recent expansions and epidemics in the temperate regions have raised concerns about the future public health impact of chikungunya diseases. Several underlying factors have likely contributed to the recent re-emergence of chikungunya infection, including urbanization, human travel, viral adaptation to mosquito vectors, lack of effective control measures, and the spread of mosquito vectors to new regions. However, the true burden of chikungunya disease is most likely to be underestimated, particularly in developing countries, due to the lack of standard diagnostic assays and clinical manifestations overlapping with those of other endemic viral infections in the regions. Additionally, there have been no chikungunya vaccines available to prevent the infection. Thus, it is important to update our understanding of the immunopathogenesis of chikungunya infection, its clinical manifestations, the diagnosis, and the development of chikungunya vaccines.

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Beda Ama, Petrus Geroda. "KEJADIAN PENYAKIT CHIKUNGUNYA DI WILAYAH KERJA PUSKESMAS KECAMATAN MAKASAR JAKARTA TIMUR." Jurnal Ilmiah Kesehatan 10, no. 2 (September 13, 2019): 146–54. http://dx.doi.org/10.37012/jik.v10i2.49.

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Chikungunya adalah suatu jenis penyakit menular yang disebabkan oleh virus Chikungunya (CHIK). Tujuan penelitian ini adalah “Diketahuinya faktor apa sajakah yang berhubungan dengan kejadian Penyakit Chikungunya di wilayah kerja Puskesmas Kecamatan Makasar Jakarta Timur”. Hasil penelitian analisis bivariate ditemukan ada dua variabel yang berhubungan dengan kejadian Penyakit Chikungunya yaitu : (1) Keberadaan jentik nyamuk : OR=2,062 dengan CI=1,169-3,636, (2) Umur : OR= 1,807 dengan CI = 1,117-2,923. Sementara variabel jenis kelamin dan pekerjaan tidak berhubungan. Hasil analisa multivariate, variabel yang berhubungan dengan Chikungunya adalah keberadaan jentik nyamuk dan umur. keberadaan jentik nyamuk merupakan variabel yang paling dominan dengan nilai OR tertingi yaitu 2,286. Sementara Umur dengan nilai OR: 1,804. Namun menurut hubungan temporal, Keberadaan jentik tidak selalu mendahului kejadian Chikungunya, sementara umur selalu mendahului kejadian Chikungunya. Oleh karena itu, walaupun secara statistic, nilai OR tertinggi pada keberadaan jentik nyamuk namun secara temporal, Umur lebih dominan. Untuk menghindari resiko terjadinya penyakit Chikungunya maka pihak puskesmas perlu melakukan edukasi ke masyarakat terkait “Self Jumantik” untuk menekan keberadaan nyamuk maupun jentik nyamuk di lingkungan rumah warga. Daftar Pustaka : 12 (2007-2015) Kata Kunci: Kejadian Penyakit Chikungunya

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40

Okabayashi, Tamaki, Tadahiro Sasaki, Promsin Masrinoul, Nantarat Chantawat, Sutee Yoksan, Narong Nitatpattana, Sarunyou Chusri, et al. "Detection of Chikungunya Virus Antigen by a Novel Rapid Immunochromatographic Test." Journal of Clinical Microbiology 53, no. 2 (November 19, 2014): 382–88. http://dx.doi.org/10.1128/jcm.02033-14.

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Chikungunya fever is a mosquito-borne disease of key public health importance in tropical and subtropical countries. Although severe joint pain is the most distinguishing feature of chikungunya fever, diagnosis remains difficult because the symptoms of chikungunya fever are shared by many pathogens, including dengue fever. The present study aimed to develop a new immunochromatographic diagnosis test for the detection of chikungunya virus antigen in serum. Mice were immunized with isolates from patients with Thai chikungunya fever, East/Central/South African genotype, to produce mouse monoclonal antibodies against chikungunya virus. Using these monoclonal antibodies, a new diagnostic test was developed and evaluated for the detection of chikungunya virus. The newly developed diagnostic test reacted with not only the East/Central/South African genotype but also with the Asian and West African genotypes of chikungunya virus. Testing of sera from patients suspected to have chikungunya fever in Thailand (n= 50), Laos (n= 54), Indonesia (n= 2), and Senegal (n= 6) revealed sensitivity, specificity, and real-time PCR (RT-PCR) agreement values of 89.4%, 94.4%, and 91.1%, respectively. In our study using serial samples, a new diagnostic test showed high agreement with the RT-PCR within the first 5 days after onset. A rapid diagnostic test was developed using mouse monoclonal antibodies that react with chikungunya virus envelope proteins. The diagnostic accuracy of our test is clinically acceptable for chikungunya fever in the acute phase.

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41

Rafe, Md Rajdoula, Syeda Naureen Ahmed, and Zebunnesa Ahmed. "Origins, pathophysiology, diagnosis, vaccination and prevention of Chikungunya virus." Current Issues in Pharmacy and Medical Sciences 32, no. 1 (March 1, 2019): 40–44. http://dx.doi.org/10.2478/cipms-2019-0009.

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Abstract Chikungunya virus is an Alphavirus that possesses characteristics similar to that of an arthropod-borne virus. Chikungunya virus has been one of the major concerns for the last few decades due to its nature of explosive spreading throughout the world. This article is intended to give detailed information about Chikungunya virus, and includes its pathogenesis, origins, diagnosis, treatment and prevention. Although, recent researches suggests various approaches to treating Chikungunya virus, extensive literature search on Chikungunya virus has revealed that, currently, there is no effective treatment available and the virus is greatly dependent on its vectors. Patients affected by Chikungunya virus mainly show symptoms of fever, arthralgia, joint pain and skin rash. Since there is no effective treatment available, public awareness is the most significant factor for potential prevention against Chikungunya virus.

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Alwin, Este Latifahanun, Diena Nur Khayati, and MB Ali Syaban. "Pola Hubungan Faktor Lingkungan Dengan Kejadian Chikungunya Di Wilayah Temanggung Jawa Tengah." Jurnal Geografi, Edukasi dan Lingkungan (JGEL) 7, no. 2 (July 26, 2023): 157–67. http://dx.doi.org/10.22236/jgel.v7i2.11579.

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In the world around 17% of human infectious diseases are caused by viruses transmitted anthropods such as chikungunya fever. Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV), a type of ribonucleic acid virus (RNA) is transmitted through Aedes aegipty bites. Acute Chikungunya infection in humans can cause sudden fever, joint pain, rashes. Indonesian was reportedly 241 cases of Chikungunya cases in 2021, in the Temanggung Regency until 2022 there were no cases of Chikungunya. On July 26, 2022 there was a suspected Chikungunya in Temanggung I Village as many as 17 people Temanggung Health Center Work Area. The aims of study was to determine relationship between environmental factors and suspected chikungunya. Research used the quantitative with a case control design. The sampling technique uses a total sampling of 17 cases with a sample ratio of 1: 1 (17 cases and 17 controls), analyzed using the Chi-square test. The results showed that environmental factors variables presence of larvae (OR 5,958, p = 0.016), presence water reservoirs (or 4,643, p = 0.037), presence of waste (OR 4,400, p = 0.039), and occupancy density (OR 5,760, p = 0.016) has a significant pattern of relationship with the suspected Chikungunya.

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Adusei, Jonathan Akwasi, Patrick Williams Narkwa, Michael Owusu, Seth Agyei Domfeh, Mahmood Alhassan, Emmanuel Appau, Alimatu Salam, and Mohamed Mutocheluh. "Evidence of chikungunya virus infections among febrile patients at three secondary health facilities in the Ashanti and the Bono Regions of Ghana." PLOS Neglected Tropical Diseases 15, no. 8 (August 30, 2021): e0009735. http://dx.doi.org/10.1371/journal.pntd.0009735.

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Background Chikungunya is now of public health concern globally due to its re-emergence in endemic areas and introduction into new areas of the world. Worldwide, the vectors for transmission of the chikungunya virus are Aedes mosquitoes and these are prevalent in Ghana. Despite its global significance, the true burden of chikungunya virus infection in Ghana is largely unknown and the threat of outbreak remains high owing to international travel. This study sought to determine chikungunya virus infection among febrile patients suspected of having malaria infections at some selected health facilities in the Ashanti, Bono East, and Bono Regions of Ghana. Methodology This cross-sectional study recruited six hundred (600) febrile patients suspected of having malaria who submitted their clinical samples to the laboratories of the selected health facilities for the diagnosis of their infections. Five to ten millilitres (5-10ml) of venous blood were collected from each study participant. Sera were separated and tested for anti-chikungunya (IgM and IgG) antibodies using InBios ELISA kit following the manufacturer’s instruction. Samples positive for chikungunya IgM and IgG were selected and tested for chikungunya virus RNA using Reverse Transcription-quantitative Polymerase Chain Reaction. Malaria Rapid Diagnostic Test kits were used to screen the participants for malaria. Structured questionnaires were administered to obtain demographic and clinical information of the study participants. Result Of the 600 samples tested, the overall seroprevalence of chikungunya was 6%. The seroprevalence of chikungunya IgM and IgG antibodies were 1.8% and 4.2% respectively. None of the chikungunya IgM and IgG positive samples tested positive for chikungunya RNA by RT-qPCR. Of the 600 samples, tested 32.3% (194/600) were positive for malaria parasites. Malaria and chikungunya co-infection was detected in 1.8% (11/600) of the participants. Conclusion Findings from the current study indicate low-level exposure to the chikungunya virus suggesting the virus is circulating and potentially causing morbidity in Ghana.

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Sativa, Alvira Rifdah, Endang Srimurni Kusmintarsih, and Trisnowati Budi Ambarningrum. "Deteksi Molekuler Virus Chikungunya pada Nyamuk Aedes aegypti Menggunakan Metode Two Step RT PCR." BioEksakta : Jurnal Ilmiah Biologi Unsoed 2, no. 2 (July 22, 2020): 218. http://dx.doi.org/10.20884/1.bioe.2020.2.2.1834.

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Demam Chikungunya adalah suatu penyakit yang disebabkan oleh virus Alphavirus dari familia Togaviridae dengan gejala postur penderita yang membungkuk akibat nyeri sendi hebat (arthalgia). Penyakit Chikungunya dapat ditularkan ke manusia melalui nyamuk vektor Aedes aegypti. Kejadian Luar Biasa (KLB) Chikungunya di Indonesia pertama kali dilaporkan pada tahun 1973 di Samarinda dan kemudian menyebar ke berbagai wilayah lainnya. Data surveil menunjukkan hampir setiap tahun terjadi KLB di berbagai wilayah di Indonesia. Pada tahun 2013 terjadi kejadian KLB Chikungunya di Purwokerto Utara, khususnya wilayah Bancarkembar dan Grendeng. Hingga saat ini belum ditemukan obat ataupun vaksin untuk mencegah penyakit Chikungunya. Tujuan penelitian ini adalah untuk mengetahui infeksi virus Chikungunya pada nyamuk dewasa Ae. aegypti. Penelitian ini dilakukan dengan metode survei dengan pengambilan sampel menggunakan teknik purposive Parameter yang diamati adalah positif nyamuk yang terinfeksi virus Chikungunya. Analisis data secara deskriptif dengan mengamati kemunculan pita DNA pada UV Transilluminator. Hasil penelitian menunjukkan bahwa amplikon cDNA CHIKV tidak terdeteksi dengan metode Two step RT-PCR. Kata Kunci : Aedes aegypti, Chikungunya, DNA, Vektor

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Setiyaningsih, Riyani, Ary Oktsari Yanti S, Mega Tyas Prihatin, Evi Sulistyorini, Dwi Susilo, Marjiyanto Marjiyanto, Mujiyanto Mujiyanto, Siti Alfiah, and Triwibowo Ambar Garjito. "ANALISIS KEBERADAAN VEKTOR STADIUM PRADEWASA DAN DEWASA TERHADAP SIRKULASI VIRUS DEMAM BERDARAH DENGUE DAN CHIKUNGUNYA DI PROVINSI DKI JAKARTA." Vektora : Jurnal Vektor dan Reservoir Penyakit 12, no. 1 (July 31, 2020): 61–72. http://dx.doi.org/10.22435/vk.v12i1.2930.

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The Special Capital Region of Jakarta is the sixth-highest province with a DHF incidence in Indonesia in 2017, however, no Chikungunya cases were found. North Jakarta, East Jakarta, and West Jakarta were reported as high endemic dengue areas. The purpose of this study to identify the behavior, distribution patterns of dengue vector and chikungunya, and their pathogens as well as their potential transmission in North, East, and West Jakarta. Entomological surveys were conducted by human landing collection, around cattle collection, animal-baited traps, and light traps. The larvae survey was also conducted in selected 100 houses in the study areas. Mosquitoes and larvae of the Aedes genus were collected and examined for the presence of dengue and chikungunya viruses using molecular analysis. The results showed that Ae. aegypti identified as the main Dengue vector and chikungunya vector in DKI Jakarta. Dengue and chikungunya vector were found in various breeding habitat indoor. During this study, Dengue and chikungunya viruses were found in North and West Jakarta. Whereas in East Jakarta only the chikungunya virus circulation was found. Abstrak Daerah Khusus Ibukota Jakarta merupakan provinsi dengan kasus demam berdarah dengue (DBD) tertinggi ke enam di Indonesia pada tahun 2017, tetapi kasus chikungunya tidak ditemukan. Wilayah dengan kasus DBD tinggi antara lain Jakarta Utara, Jakarta Timur dan Jakarta Barat. Faktor yang mempengaruhi peningkatan kasus DBD dan chikungunya di suatu daerah antara lain keberadaan vektor dan patogennya. Tujuan penelitian adalah mengetahui perilaku, pola distribusi vektor DBD dan Chikungunya, patogen; serta potensi penularannya di Jakarta Utara, Timur, dan Barat Provinsi DKI Jakarta. Metode penangkapan nyamuk dilakukan dengan umpan orang, umpan ternak, animal-baited trap dan light trap. Survei jentik dilakukan di 100 bangunan masing-masing di Jakarta Utara, Jakarta Timur dan Jakarta Barat. Keberadaan patogen pada nyamuk dan jentik dari genus Aedes diperiksa secara molekuler. Hasil penelitian menunjukkan vektor DBD dan chikungunya di DKI Jakarta adalah Aedes aegypti. Nyamuk ini ditemukan dominan pada siang hari namun juga berhasil dikoleksi pada malam hari. Tempat perkembangbiakan vektor DBD dan chikungunya cenderung ditemukan di berbagai tempat penampungan air di dalam rumah. Sirkulasi virus DBD dan chikungunya ditemukan di wilayah Jakarta Utara dan Barat, sedangkan di Jakarta Timur hanya diemukan sirkulasi virus chikungunya.

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Fraiman, Pedro Henrique Almeida, Mariana Freire, Bruno Fernandes, Felipe Palitot, Nathalia Mota, Eduardo Sequerra, Glauco Santos, Mario Emilio Dourado, Clecio de Oliveira Godeiro-Junior, and Manuel Moreira-Neto. "“Clock dial pattern”, a radiologic clue to neuro-chikungunya diagnosis: a case series." Arquivos de Neuro-Psiquiatria 82, no. 01 (January 2024): 001–6. http://dx.doi.org/10.1055/s-0044-1779033.

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Abstract Background Chikungunya is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and can lead to neurological complications in severe cases. Objective This study examined neuroimaging patterns in chikungunya cases during two outbreaks in Brazil to identify specific patterns for diagnosis and treatment of neuro-chikungunya. Methods Eight patients with confirmed chikungunya and neurological involvement were included. Clinical examinations and MRI scans were performed, and findings were analyzed by neuroradiologists. Data on age, sex, neurological symptoms, diagnostic tests, MRI findings, and clinical outcomes were recorded. Results Patients showed different neuroimaging patterns. Six patients exhibited a “clock dial pattern” with hyperintense dotted lesions in the spinal cord periphery. One patient had thickening and enhancement of anterior nerve roots. Brain MRI revealed multiple hyperintense lesions in the white matter, particularly in the medulla oblongata, in six patients. One patient had a normal brain MRI. Conclusion The “clock dial pattern” observed in spinal cord MRI may be indicative of chikungunya-related nervous system lesions. Isolated involvement of spinal cord white matter in chikungunya can help differentiate it from other viral infections. Additionally, distinct brainstem involvement in chikungunya-associated encephalitis, particularly in the rostral region, sets it apart from other arboviral infections. Recognizing these neuroimaging patterns can contribute to early diagnosis and appropriate management of neuro-chikungunya.

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Guillot, Xavier, Anne Ribera, and Philippe Gasque. "Chikungunya-Induced Arthritis in Reunion Island: A Long-Term Observational Follow-Up Study Showing Frequently Persistent Joint Symptoms, Some Cases of Persistent Chikungunya Immunoglobulin M Positivity, and No Anticyclic Citrullinated Peptide Seroconversion After 13 Years." Journal of Infectious Diseases 222, no. 10 (May 19, 2020): 1740–44. http://dx.doi.org/10.1093/infdis/jiaa261.

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Abstract Background Reunion Island was struck by a massive Chikungunya outbreak in 2005–2006. Chikungunya infection is characterized by inflammatory joint symptoms, which may evolve into chronic arthritis. Methods In this long-term longitudinal observational monocentric study, after the 2005–2006 outbreak in Reunion Island, 159 patients were first referred to a rheumatologist for post-Chikungunya chronic musculoskeletal pain, 73 of them were diagnosed with classifiable Chikungunya-related chronic inflammatory rheumatic diseases (>3 month symptom duration from the initial viral infection). Thirty of these 73 patients were clinically evaluated by a second rheumatologist in 2018–2019. The main objective of this second examination was to estimate the proportion of patients with persistent Chikungunya-related inflammatory joint symptoms after 13 years. Results Inflammatory joint symptoms persisted in 17/30 patients after 13 years (therefore in at least 23.3% of the 73 patients initially diagnosed with Chikungunya-related inflammatory joint symptoms and 10.7% of the 159 patients referred for post-Chikungunya chronic musculoskeletal pain). In the symptom persistence subgroup, the prevalence of positive autoantibodies (antinuclear or ACPA) was significantly higher – without any seroconversion, Chikungunya IgG and IgM levels were higher, long-term IgM positivity and radiographic damage were more frequent. Overall, after 13 years, pain and fatigue levels remained significant, 5 patients were still treated by methotrexate, 3 by TNF-blockers, highlighting long-term Chikungunya-related patient burden. Conclusions Such a long-term persistence of Chikungunya-related chronic inflammatory rheumatic diseases had not been reported so far. Furthermore, the long-term Chikungunya IgM positivity we observed in some cases might corroborate the hypothesis of residual viral antigen-driven chronic arthritis.

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Singla, Ipsa, Haripriya Bansal, and Tavishi Oberoi. "Chikungunya Infection: A Potential Re-Emerging Global Threat." International Journal of Health Sciences and Research 14, no. 5 (May 7, 2024): 155–59. http://dx.doi.org/10.52403/ijhsr.20240517.

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Background- Arboviral diseases, such as chikungunya dengue and now zika represent a problem. Epidemiology of chikungunya and dengue is well known, including its social and climatic factors associated, but only few data and reports of chikungunya are available. The clinical differentiation of chikungunya from dengue is no doubt challenging since both diseases can share clinical signs and symptoms leading to potential misdiagnosis of chikungunya in areas where dengue is endemic resulting in delayed treatment and high morbidity. Aim & Objective- To assess seroprevalence, clinical presentations and seasonal trends of chikungunya infection in this region. Material and method- The study was conducted in the Department of Microbiology, Government Medical College, Amritsar from January 2023 to December 2023. The serum samples were subjected to IgM antibody capture enzyme linked immunosorbent assay (MAC-ELISA) for detection of anti-chikungunya virus IgM antibodies. Result- Overall, 52% (241/465) clinical samples were positive by MAC-ELISA. Females were more affected than males and age group >45 years was mostly affected. Fever (100%) was the primary symptom. Maximum cases were detected in the months of August to October with peak in September month. Majority of the cases were reported from rural area (94.8%). Conclusion- In this study, seroprevalence of Chikungunya was significantly high. Though Chikungunya is a self-limiting infection, increasing morbidity by Chikungunya virus infection is affecting social and economic status of individual. Thus, a community empowerment to effectively control mosquito population by employing different mosquito control measures along with personal protection is mandatory to tackle future outbreak of the disease. Key words: Chikungunya, Neglected disease, re-emerging, IgM antibody capture enzyme linked immunosorbent assay write relevant keywords

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Santoso, Marsha Sinditia, Sotianingsih Haryanto, Fadil Rulian, Rahma F. Hayati, Amanda Kristiani, Rini Kartika, Benediktus Yohan, Martin L. Hibberd, and R. Tedjo Sasmono. "Continuous Circulation of Chikungunya Virus during COVID-19 Pandemic in Jambi, Sumatra, Indonesia." Tropical Medicine and Infectious Disease 7, no. 6 (June 5, 2022): 91. http://dx.doi.org/10.3390/tropicalmed7060091.

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Chikungunya fever is a self-limiting viral illness that is caused by the chikungunya virus (CHIKV). CHIKV is found in multiple provinces of Indonesia, with clustered local outbreaks. This case series investigates a local chikungunya outbreak during the COVID-19 pandemic, involving two virologically confirmed chikungunya cases found in Jambi, Sumatra, Indonesia in 2021 and the contact tracing of 65 people from the same neighborhood (one of which was also virologically confirmed with CHIKV). The two original cases were symptomatic with classic signs of chikungunya fever, while the CHIKV-positive neighbor was asymptomatic. Out of the 65 participants, chikungunya IgM was detected in seven (10.8%) people while chikungunya IgG was detected in six (9.2%) using capture ELISA. Dengue IgG was detected by rapid test in three (4.6%) of the participants, showcasing a history of dengue virus (DENV) infection along with the circulation of CHIKV in the area. A phylogenetic analysis demonstrates a close evolutionary relationship between all three 2021 Jambi CHIKV isolates and the 2015–2016 isolates from Jambi. This case series showcases the endemicity and persistent circulation of CHIKV in Jambi, leaving the area vulnerable to eminent outbreaks of chikungunya fever and doubling the burden of disease during the COVID-19 pandemic. Health staff training for case detection and notification, as well as an integrated vector surveillance should continue to be implemented to provide an early warning indicator of possible chikungunya outbreaks.

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Haque, Hasna Fahmima, Farhana Afroz, Samira Rahat Afroze, Muhammad Abdur Rahim, Najeeb Mahiuddin, Mohammad Gaffar Amin, and AKM Musa. "Dengue-Chikungunya Co-Infection: A Case Report from 2017-Chikungunya Outbreak in Dhaka, Bangladesh." BIRDEM Medical Journal 8, no. 1 (December 27, 2017): 72–74. http://dx.doi.org/10.3329/birdem.v8i1.35044.

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A case of dengue virus and chikungunya viruse co-infection is reported here. The patient had fever, severe generalized bodyache, arthritis as well as drowsiness. Laboratory investigations showed dengue-chikungunya co-infection. The objective of our report is to emphasize the co-existence of dengue and chikungunya in a clinical case and to aware the clinicians about chikungunya and dengue co-infection.Birdem Med J 2018; 8(1): 72-74

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