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Relevant bibliographies by topics / Chemotherapy-induced mucositis

Academic literature on the topic 'Chemotherapy-induced mucositis'

Author: Grafiati

Published: 10 December 2022

Last updated: 10 March 2023

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Journal articles on the topic "Chemotherapy-induced mucositis"

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Sadasivan, Raj. "Chemotherapy-induced Oral Mucositis." Oncology & Hematology Review (US) 06 (2010): 13. http://dx.doi.org/10.17925/ohr.2010.06.0.13.

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Oral mucositis is one of the most common side effects cancer patients experience when undergoing chemotherapy. However, it is frequently under-reported and leads to high morbidity and complication rates. Advances in molecular biology have provided greater insight into the pathophysiology of this condition. Although there are no current treatments that completely resolve this painful condition, encouraging research developments indicate that a new, over-the-counter pH-balanced salt solution, reBalanceCa, shows promise.

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Knox, Jennifer J., Anitasha L. V. Puodziunas, and Ronald Feld. "Chemotherapy-Induced Oral Mucositis." Drugs & Aging 17, no. 4 (October 2000): 257–67. http://dx.doi.org/10.2165/00002512-200017040-00002.

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Lalla, Rajesh V., Deborah P. Saunders, and Douglas E. Peterson. "Chemotherapy or Radiation-Induced Oral Mucositis." Dental Clinics of North America 58, no. 2 (April 2014): 341–49. http://dx.doi.org/10.1016/j.cden.2013.12.005.

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Keefe, Dorothy M., Stephen T. Sonis, and Joanne M. Bowen. "Emerging drugs for chemotherapy-induced mucositis." Expert Opinion on Emerging Drugs 13, no. 3 (September 2008): 511–22. http://dx.doi.org/10.1517/14728214.13.3.511.

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Huang, Junhua, Alan Yaw Min Hwang, Yuting Jia, Brian Kim, Melania Iskandar, Ali Ibrahim Mohammed, and Nicola Cirillo. "Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models." International Journal of Molecular Sciences 23, no. 23 (December 6, 2022): 15434. http://dx.doi.org/10.3390/ijms232315434.

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Mucositis is a common and most debilitating complication associated with the cytotoxicity of chemotherapy. The condition affects the entire alimentary canal from the mouth to the anus and has a significant clinical and economic impact. Although oral and intestinal mucositis can occur concurrently in the same individual, these conditions are often studied independently using organ-specific models that do not mimic human disease. Hence, the purpose of this scoping review was to provide a comprehensive yet systematic overview of the animal models that are utilised in the study of chemotherapy-induced mucositis. A search of PubMed/MEDLINE and Scopus databases was conducted to identify all relevant studies. Multiple phases of filtering were conducted, including deduplication, title/abstract screening, full-text screening, and data extraction. Studies were reported according to the updated Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. An inter-rater reliability test was conducted using Cohen’s Kappa score. After title, abstract, and full-text screening, 251 articles met the inclusion criteria. Seven articles investigated both chemotherapy-induced intestinal and oral mucositis, 198 articles investigated chemotherapy-induced intestinal mucositis, and 46 studies investigated chemotherapy-induced oral mucositis. Among a total of 205 articles on chemotherapy-induced intestinal mucositis, 103 utilised 5-fluorouracil, 34 irinotecan, 16 platinum-based drugs, 33 methotrexate, and 32 other chemotherapeutic agents. Thirteen articles reported the use of a combination of 5-fluorouracil, irinotecan, platinum-based drugs, or methotrexate to induce intestinal mucositis. Among a total of 53 articles on chemotherapy-induced oral mucositis, 50 utilised 5-fluorouracil, 2 irinotecan, 2 methotrexate, 1 topotecan and 1 with other chemotherapeutic drugs. Three articles used a combination of these drugs to induce oral mucositis. Various animal models such as mice, rats, hamsters, piglets, rabbits, and zebrafish were used. The chemotherapeutic agents were introduced at various dosages via three routes of administration. Animals were mainly mice and rats. Unlike intestinal mucositis, most oral mucositis models combined mechanical or chemical irritation with chemotherapy. In conclusion, this extensive assessment of the literature revealed that there was a large variation among studies that reproduce oral and intestinal mucositis in animals. To assist with the design of a suitable preclinical model of chemotherapy-induced alimentary tract mucositis, animal types, routes of administration, dosages, and types of drugs were reported in this study. Further research is required to define an optimal protocol that improves the translatability of findings to humans.

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Thomsen, Michael, and Luis Vitetta. "Adjunctive Treatments for the Prevention of Chemotherapy- and Radiotherapy-Induced Mucositis." Integrative Cancer Therapies 17, no. 4 (August 23, 2018): 1027–47. http://dx.doi.org/10.1177/1534735418794885.

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Background: Chemoradiotherapy-associated mucositis can manifest as pain, inflammation, dysphagia, diarrhea, weight loss, rectal bleeding, and infection. Mucositis is a major dose-limiting side effect of chemotherapy, affecting nutritional intake and oral and intestinal function. Despite several interventions being available, there is a need for safe and effective preventative and treatment options for treatment-induced mucositis. The goals of this review are to discuss interventions based on foods and natural products and present the research to date. Methods: A narrative literature review identified 60 clinical studies examining various nutritional compounds and 20 examining probiotics. 9 studies on probiotics for the prevention of diarrhea were also assessed on methodological quality and limitations identified. Results: Several compounds have been posited as useful adjuvants for cancer treatment–related mucositis. Probiotics demonstrate efficacy for the prevention and treatment of chemoradiotherapy-induced gastrointestinal toxicity without significant side effects. Glutamine and activated charcoal were reported to reduce chemotherapy-induced diarrhea but not radiation-induced intestinal mucositis. Honey has been reported to decrease treatment interruptions, weight loss, and delays the onset of oral mucositis. Zinc, glutamine, and topical vitamin E were demonstrated efficacy for oral mucositis. Conclusion: There is plausible clinical evidence for the administration of several adjunctive treatments for the prevention and treatment of mucositis. Probiotics were reported to reduce the burden of intestinal mucositis and treatment-induced diarrhea. Activated charcoal and glutamine are beneficial for chemotherapy-induced diarrhea, whereas the administration of honey, zinc, and glutamine reduce the risk of developing oral mucositis during chemotherapy or radiotherapy.

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Patel, Alkesh, Subhankar Biswas, Muhammed Haneefa Shoja, Grandhi Venkata Ramalingayya, and K. Nandakumar. "Protective Effects of Aqueous Extract ofSolanum nigrumLinn. Leaves in Rat Models of Oral Mucositis." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/345939.

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Oral mucositis is one of the most debilitating side effects in patient undergoing chemotherapy or chemoradiotherapy. Leaves of the plantSolanum nigrumare used in folklore medicine to treat oral ulcers in India. However, no pharmacological investigation has been carried out till date. Aqueous extract ofSolanum nigrumleaves (AESN) was prepared and subjected to various phytochemical screening. HPLC analysis of the ethyl acetate fraction was carried out. The aqueous extract (100 and 200 mg/kg) was further evaluated for its protective effect on two rat models: (a) busulfan plus infrared radiation (chemoradiotherapy) induced oral mucositis and (b) methotrexate (chemotherapy) induced oral mucositis. Various parameters including body weight change, food intake, and mortality were measured. AESN showed protective effect in both models of oral mucositis; however, the higher dose was more effective in chemotherapy induced oral mucositis. A reduction in oral mucositis score(P<0.05)was observed in the treatment groups. Significant(P<0.05)improvement in food intake was also observed in AESN treated groups. Aqueous extract ofSolanum nigrumleaves has protective effect on chemotherapy and chemoradiotherapy induced oral mucositis in rats.

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Wei, Ling, Xue-Sen Wen, and Cory J. Xian. "Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways." International Journal of Molecular Sciences 22, no. 17 (August 31, 2021): 9474. http://dx.doi.org/10.3390/ijms22179474.

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Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–100% of patients undergoing chemotherapy, can reduce the patients’ quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies.

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Cidon, E. Una. "Chemotherapy induced oral mucositis: prevention is possible." Chinese Clinical Oncology 7, no. 1 (February 2018): 6. http://dx.doi.org/10.21037/cco.2017.10.01.

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Una-Cidon, Maria Esther. "Chemotherapy-induced oral mucositis: prevention is possible." Clinical Medicine 19, Suppl 2 (March 2019): s5. http://dx.doi.org/10.7861/clinmedicine.19-2-s5.

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Dissertations / Theses on the topic "Chemotherapy-induced mucositis"

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Mulholland, K. C. "Experimental chemotherapy-induced mucositis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479433.

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Koning, Barbara Anna Eleonora de. "Chemotherapy induced intestinal mucositis: from bench to bed." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/10865.

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Tran, Cuong Duy. "Intestinal zinc and metallothionein : role in chemotherapy-induced mucositis." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc9736.pdf.

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Bowen, Joanne Marie. "Chemotherapy-induced intestinal mucositis the role of apoptosis regulators /." Click here to access, 2006. http://thesis.library.adelaide.edu.au/public/adt-SUA20060831.142913/index.html.

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Thesis (Ph.D.) -- University of Adelaide, School of Medicine, Discipline of Medicine, 2006.
Includes author's previously published papers. "March 2006" Bibliography: leaves 168-191. Also available in a print form.

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Bingham, J. M. M. "Gut mucosal architecture and barrier function in chemotherapy induced mucositis." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411063.

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Williams, Evan, and Jacob Dale Stearley. "Physicochemical Properties of a ‘Magic Mouthwash’ for Chemotherapy Induced Oral Mucositis." The University of Arizona, 2011. http://hdl.handle.net/10150/623534.

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Class of 2011 Abstract
OBJECTIVES: To determine the solubility and stability of hydrocortisone in a ‘magic mouthwash; suspension. METHODS: A literature review was conducted to establish the most common ingredients in a ‘magic mouthwash’ suspension It was decided that the test suspension would consist of 75% commercially available diphenhydramine solution, 12.5% nystatin suspension (100,000 units/ml) , and 12.5% lidocaine solution (2% lidocaine). Powdered hydrocortisone was then added to the test suspensions at different concentrations and stored at 27C, 38C, and 48C. Aliquots were taken from each of the test samples at the time of compounding and at 4, 7, 13, 19, and 26 days to be analyzed by HPLC for degradation of hydrocortisone and percent hydrocortisone in suspension. RESULTS: At 27C, 98.5% of hydrocortisone was recovered after 26 days, versus 33.7% at 38C, and 7% at 48C. The solubility of hydrocortisone in the suspension was higher at higher temperatures, with 82% in solution at 48C, 70% at 38C, and 38% at 27C. CONCLUSION: The amount of hydrocortisone recovered deteriorated over time and at higher temperatures, and solubility of hydrocortisone in the suspension was greater at higher temperatures.

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Gibson, Rachel J. "Chemotherapy-induced mucositis : mechanisms of damage, time course of events and possible preventative strategies /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phg4481.pdf.

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Poon, Sze-wan, and 潘詩尹. "An evidence-based guideline on using cryotherapy for chemotherapy-induced oral mucositis in adult cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48339192.

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Oral mucositis is a common adverse side-effect caused by cancer treatments and can lead to mucosa toxicity. Patients with oral mucositis may experience extreme pain and may not be able to eat, drink and talk and, as a result, their quality of life is impaired. Thirty to eighty five percent of patients undergoing chemotherapy would develop oral mucositis. Preventing or reducing incidence of oral mucositis and its severity can help reduce patients’ sufferings. One of the methods to achieve this objective is the oral cryotherapy, which is a prophylactic intervention. However, there is no evidence-based guideline to instruct nurses on providing oral cryotherapy to cancer patients. The aims of this study are 1) to establish an evidence-based guideline on applying cryotherapy to reduce the incidence and severity of chemotherapy-induced oral mucositis, 2) to develop a standard nursing care and assess its transferability and feasibility, and 3) to develop a communication plan and evaluation plan for this guideline in an oncology ii- department for the targeted local hospitals in Hong Kong. A systematic search of four electronic journal databases identified seven articles corresponding to 6 randomized controlled trials (RCTs) on using oral cryotherapy for adult cancer patients. Five RCTs with high to weak quality reported supporting evidence for the beneficial effect of oral cryotherapy on chemotherapy-induced oral mucositis, whereas 1 RCT with moderate quality failed to identify supportive evidence for the use of oral cryotherapy. However, potential confounding factors were identified to be presented in that insignificant RCT. Hence, there was sufficient evidence to show that oral cryotherapy can significantly reduce chemotherapy-induced oral mucositis in adult cancer patients. An evidence based guideline for using cryotherapy on chemotherapy-induced oral mucositis in adult cancer patients was established. The transferability and feasibility of the proposed oral cryotherapy guideline were assessed. As identified, the clinical situation and patient characteristics in the local settings are similar to those who reported in the reviewed studies. Staff readiness, skills and resources are also readily available in the target clinical settings. Findings from the reviewed studies of oral cryotherapy can be transferred to the local target settings and are feasible to be implemented. It is also estimated that the innovated guidelines for cryotherapy can save HK$3,210,745 per year for the target setting. Stakeholders for the innovated guideline in the local setting were identified. And a communication plan was developed. A pilot study lasting for 10 weeks will be conducted to test the feasibility of the staff training session and the implementation of the oral cryotherapy guideline. Modification of innovated guidelines will be made after evaluating the data collected from the pilot study. Eventually, the final version of the evidence-based guideline will be established. A six months evaluation plan will be used to evaluate the implementation of the new guideline. The policy for adopting the oral cryotherapy will be determined with the outcome measures, including the incidence of chemotherapy-induced oral mucositis, mean of the oral mucositis score, staff satisfaction level, and the cost and benefit ratio of the innovated guideline.
published_or_final_version
Nursing Studies
Master
Master of Nursing

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Hotama, Peggy Yulia [Verfasser]. "The role of Herpes Simplex Virus in chemotherapy-induced Mucositis in pediatric patients / Peggy Yulia Hotama." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2014. http://d-nb.info/1052530168/34.

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Ivester, Clifford. "15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.

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Books on the topic "Chemotherapy-induced mucositis"

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Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in pediatric patients: A pilot study. 2004.

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Book chapters on the topic "Chemotherapy-induced mucositis"

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Rosenthal, C., M. Karthaus, and A. Ganser. "New Strategies in the Treatment and Prophylaxis of Chemo- and Radiotherapy-Induced Oral Mucositis." In Antibiotics and Chemotherapy, 115–32. Basel: KARGER, 1999. http://dx.doi.org/10.1159/000059321.

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Ciorba, M. A. "The Prevention and Treatment of Radiation and Chemotherapy-Induced Intestinal Mucositis." In The Microbiota in Gastrointestinal Pathophysiology, 383–87. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-804024-9.00041-0.

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Conference papers on the topic "Chemotherapy-induced mucositis"

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Chaucer, B., A. Stone, R. M. Davis, and B. S. Aulakh. "Fatal Chemotherapy-Induced Mucositis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4827.

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Iwamoto, M., N. Umezaki, J. Matsuda, K. Kawaguchi, R. Terasawa, N. Sato, H. Fyjioka, K. Kimura, S. Tanaka, and K. Uchiyama. "Abstract OT3-02-01: Randomized phase II study of Hangeshashinto (TJ-14) for chemotherapy induced oral mucositis in patients with breast cancer (Hangesha-B study)." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-ot3-02-01.

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