Relevant bibliographies by topics / Chemotherapy

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Chemotherapy'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Chemotherapy"

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Akl, Maher Monir. "Glucosodiene: Opening a New Branch of Chemotherapic Sciences Called Toxinutromedicanical-Chemotherapy." Cell & Cellular Life Sciences Journal 8, no. 2 (2023): 1–2. http://dx.doi.org/10.23880/cclsj-16000185.

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Chemotherapy is a widely employed treatment modality in the fight against cancer aiming to eliminate both normal and cancerous cells. However, its non-discriminatory nature leads to severe side effects
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Armini, Ni ketut alit, Masfin Muhayanah, and Aria Nastiti. "DIARRHEA INCIDENT IN CERVICAL CANCER PATIENTS POST CHEMOTHERAPY TREATMENT." Jurnal NERS 11, no. 1 (April 1, 2016): 106. http://dx.doi.org/10.20473/jn.v11i12016.106-111.

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Backgrounds : Cervical cancer is second most diseases suffered by women. Chemotherapy is primary treatment for cervical cancer. Chemotherpy has some side effect, and one of them is diarrhea. Diarrhea make cervical cancer suffered more. The purpose of this research was to analyze the correlation of factor’s that cause diarrhea on cervical cancer.Methods : This research uses descriptive analitic method with retrospective design. The population in this research is all patients who had post first chemotherapy. Sample in this study were 21 respondents, with purposive sampling. Variable independent were type of chemotherapy drugs, character of chemotheraphy, staging, stress and dietary. Variable dependent was diarrhea. Data collected using quesionare. Data were analyzed using chi square test with level of significant α≤0,05.Results : The result of the study reveals that type of the chemotherapy drug p:0,598, character of chemotheraphy p:0,336,. Staging has correlation with diarrhea significant of p:0,022. Stress and dietary analysisis presented p:0,00. It means that there was significant correlation with diarrhea.Conclusion : It can be concluded that diarrhea incident related to staging, stress and dietarry. There‘s no correlation between type of chemotherapy drug, character of chemotheraphy with diarrhea Further studies should give health education about dietary causing diarrhea, chemotherapy procedural and sides effect’s, increase supports for patient with cervical cancer. Keyword: Cervical Cancer, Chemotherapy, Diarrhea.
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Armini, Ni ketut alit, Masfin Muhayanah, and Aria Nastiti. "The Incident of Diarrhea among Cervical Cancer Patients Post Chemoterapy Treatment." Jurnal Ners 11, no. 1 (April 1, 2016): 106–11. http://dx.doi.org/10.20473/jn.v11i1.1357.

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Backgrounds : Cervical cancer is second most diseases suffered by women. Chemotherapy is primary treatment for cervical cancer. Chemotherpy has some side effect, and one of them is diarrhea. Diarrhea make cervical cancer suffered more. The purpose of this research was to analyze the correlation of factor’s that cause diarrhea on cervical cancer.Methods : This research uses descriptive analitic method with retrospective design. The population in this research is all patients who had post first chemotherapy. Sample in this study were 21 respondents, with purposive sampling. Variable independent were type of chemotherapy drugs, character of chemotheraphy, staging, stress and dietary. Variable dependent was diarrhea. Data collected using quesionare. Data were analyzed using chi square test with level of significant α≤0,05.Results : The result of the study reveals that type of the chemotherapy drug p:0,598, character of chemotheraphy p:0,336,. Staging has correlation with diarrhea significant of p:0,022. Stress and dietary analysisis presented p:0,00. It means that there was significant correlation with diarrhea.Conclusion : It can be concluded that diarrhea incident related to staging, stress and dietarry. There‘s no correlation between type of chemotherapy drug, character of chemotheraphy with diarrhea Further studies should give health education about dietary causing diarrhea, chemotherapy procedural and sides effect’s, increase supports for patient with cervical cancer.
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Dougherty, Lisa. "Practical Chemotherapy Practical Chemotherapy." Nursing Standard 17, no. 41 (June 25, 2003): 29. http://dx.doi.org/10.7748/ns2003.06.17.41.29.b333.

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S., Karthik, Seenivasan P., and Rajanandh M.G. "Pattern of Chemotherapy Induced Alopecia." Indian Journal of Cancer Education and Research 4, no. 2 (2016): 45–47. http://dx.doi.org/10.21088/ijcer.2321.9815.4216.1.

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Fitrianingsih, Nining. "HUBUNGAN TINGKAT PENGETAHUAN PERAWAT TENTANG KEMOTERAPI DENGAN TINDAKAN PEMBERIAN KEMOTERAPI PADA PASIEN KANKER PARU." Jurnal Persatuan Perawat Nasional Indonesia (JPPNI) 1, no. 3 (March 16, 2017): 207. http://dx.doi.org/10.32419/jppni.v1i3.31.

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ABSTRAKLatar Belakang: Kemoterapi merupakan salah satu cara pengobatan kanker dengan memberikanobat atau zat yang berkhasiat membunuh sel kanker. Dalam tindakan medis, perawat harusmemiliki pengetahuan tentang prosedur pemberian obat kemoterapi karena pemberian kemoterapiyang dilakukan oleh perawat rentan terkena pada kulit atau mata pada saat melakukan tindakan.Tujuan Penelitian: mengetahui hubungan tingkat pengetahuan perawat tentang kemoterapidengan tindakan pemberian kemoterapi pada pasien kanker paru. Metode: Desain penelitianyang digunakan ialah analisis korelasional dengan pendekatan cross sectional. Populasi yangditeliti adalah perawat berjumlah 46 dengan teknik pengambilan sampel total sampling. Instrumenpenelitian berupa uesioner dan lembar observasi. Analisis data secara univariat dan divariat. Hasil:hasil penelitian menunjukkan nilai uji statistik chi square dengan p value = 0,001 (≤ 0,05), hal iniberarti ada hubungan antara tingkat pengetahuan perawat tentang kemoterapi dengan tindakanpemberian kemoterapi pada pasien kanker paru. Diskusi: seseorang yang mempunyai tingkatpengetahuan, pengalaman kerja yang banyak, serta diikuti bertambahnya usia akan memberikanpelayanan/perawatan dalam pemberian kemoterapi yang lebih baik hasilnya. Simpulan: perawatyang memiliki pengetahuan yang baik tentang kemoterapi akan memberikan tindakan kemoterapiyang sesuai dengan prosedur.Kata Kunci: Pengetahuan, kemoterapi, kanker paru.THE CORRELATION BETWEEN KNOWLEDGE LEVEL OF NURSES ABOUT CHEMOTHERAPHYAND CHEMOTHERAPHY ADMINISTRATION IN LUNG CANCER PATIENTSABSTRACTBackground: Chemotherapy is one of the methods in treating cancer by providing effi cacious drugs orsubstances that kill cancer cells. In a medical procedure, nurses must have knowledge of proceduresfor chemotherapy regimens because the chemotherapy conducted by nurses is susceptible to skinor eyes at the time of the intervention. Objective: To identify the correlation between knowledgelevel of nurses about chemotheraphy and chemotheraphy administration in lung cancer patients.Methods: This study was correlational analytical with cross sectional approach. Samples were46 nurses taken using total sampling technique. Questionnaire observation sheet were used asinstruments. Data was analyzed with univariate and bivariate. Results: There was a correlationbetween knowledge level of nurses about chemotherapy and chemotherapy administration, pvalue=0.001 (≤ 0.05). Discussion: One who has higher level of knowledge, a lot of work experience,and get older will administer better chemotherapy. Conclusions: Nurses with comprehensiveknowledge of chemotherapy will administer chemotherapy in accordance with procedure.Keywords: Knowledge level, Chemotherapy, Lung Cancer
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Winata, I. Gde Sastra GdeSastra. "Neoadjuvant Chemotherapy In Stadium Ib3, Iia2 And Iib Cervical Cancer." Andalas Obstetrics And Gynecology Journal 7, no. 1 (March 2, 2023): 214–24. http://dx.doi.org/10.25077/aoj.7.1.214-224.2023.

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Aim: This study aimed to describe Paclitaxel-Carboplatin chemotherapy as neoadjuvant chemotherapy in stage IB3, IIA2 and IIB cervical cancer. Materials and Methods: The review was conducted by collecting journals from previous studies discussing neoadjuvant chemotherapy in cervical cancer stages IB3, IIA2, and IIB and in this case specifically discussing Paclitaxel-Carboplatin chemotherapy. Results: Neoadjuvan chemotherapy refers to systemic therapy intended to reduce the size of the tumor before the definitive operation. Several studies have shown that neoadjuvant chemotherapy has greater advantages than surgery alone for early stage cancers (IB3, IIA2, and IIB). Paclitaxel and Carboplatin are known chemotherapeutic agents that can be used as neoadjuvant chemotherapy. Conclusions: Neoadjuvant Chemotherapy regimen Paclitaxel Carboplatin is one of the options in performing therapy for early stage cervical cancer which can be very helpful in healing and cancer-free patient condition. Neoadjuvant chemotherapy followed by radical surgery has significant benefits that have been described in several previous studies.  Clinical Significance: Neoadjuvant Chemotherapy regimen Paclitaxel Carboplatin may be used as therapy regimen for early stage cervical cancer with all advantage compared to only surgery. Thus, this type of regimen can be used to decrease mortality and morbidity in patient with stadium IB3, IIA2 and IIB cervical cancer.Â
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Friedrich, Michael, Alexander Khudyakov, Arne Terjung, Wolfgang Zinn, and Ulrich Füllers. "Influence of hyperthermic intraperitoneal chemotherapy (HIPEC) on the onset of adjuvant chemotherapy in ovarian cancer." Voprosy ginekologii, akušerstva i perinatologii 21, no. 2 (2022): 14–17. http://dx.doi.org/10.20953/1726-1678-2022-2-14-17.

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Objective. To determine the benefits of intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced ovarian cancer. Patients and methods. The study included 87 patients, while 74 patients had epithelial ovarian cancer and 13 patients showed other neoplasms. At the end of the operation, a 1-hour perfusion of the abdominal cavity was performed with cisplatin 50 mg/m2 at a temperature of 41°C. The patient data was retrospectively analyzed considering the time interval of postoperative chemotherapy based on the guideline. Results. Sixty patients manifested macroscopic tumor clearance (81.1%), 13 patients (17.6%) – residual tumor <1 cm, and 1 patient (1.4%) – a residual tumor >1 cm. Postoperative chemotherapy was performed in 72 patients (92.3%). The average interval between HIPEC and induction of postoperative chemotherapy lasted 37 days. Conclusion. In case of complete resection of the tumor, intraperitoneal chemotherapy with cisplatin can improve the prognosis for advanced ovarian cancer. HIPEC does not reduce the use of postoperative systemic chemotherapy, though a new approach to chemotherapy presented in the article facilitates a more uniform distribution of the chemotherapeutic drug inside the intraperitoneal cavity, and, thereby, micro metastases in the late stages of ovarian cancer are more effectively suppressed. Key words: epithelial ovarian cancer, intraoperative hyperthermic intraperitoneal chemotherapy, cisplatin, postoperative chemotherapy
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Chung, Fu-Tsai, Ming-Yun Ho, Yueh-Fu Fang, Meng-Heng Hshieh, Tsai-Yu Wang, Chih-Hsi Kuo, Hao-Cheng Chen, et al. "The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on DifferentEGFRMutation Lung Adenocarcinoma." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/948267.

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Objectives. Chemotherapy as first-/second-line treatment in different epidermal growth factor receptor (EGFR) mutation lung adenocarcinoma remains controversial.Methods. Consecutive patients were collected between 2009 and 2012. Patients were divided into two groups (1st-line chemotherapy:n= 56 and 2nd-line chemotherapy:n= 55). Their outcomes profiles were analyzed.Results. The overall survival (OS) of all patients (390 versus 662 days,p< 0.0001), as well as both progression-free survival (PFS, 151 versus 252 days,p= 0.0001) and OS (308 versus 704 days,p= 0.0001) of patients withL858Rmutation (n= 63), who received 2nd-line chemotherapy, was significantly poor. By univariate and multivariate analysis, 2nd-line chemotherapy, andL858Rmutation were significantly related to poor PFS and OS.Conclusion. In advanced lung adenocarcinoma,L858Rmutation and 2nd-line chemotherapy caused a poor outcome. It is a consideration to choice of 1st-line chemotherapy in these subjects. A prospective design is warranted to confirm this finding.
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(R.T), Dr C. S. K. Prakash, M. D. "Nasopharyngeal Carcinoma- Role of External Beam Radiotherapy (EBRT) and Chemotherapy Vs EBRT, Chemotherapy and Intraluminal Brachytherapy." Journal of Medical Science And clinical Research 04, no. 10 (October 27, 2016): 13348–61. http://dx.doi.org/10.18535/jmscr/v4i10.92.

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Dissertations / Theses on the topic "Chemotherapy"

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McGrath, Pamela. "Chemotherapy : Treatment Experimentation or Illusion? : a Study into the Bioethics of Chemotherapy." Thesis, Queensland University of Technology, 1993.

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The use of cytotoxic drugs, Chemotherapy, is considered by many a valid modality in the treatment of cancer. The use of this modality in the 1950's and 1960's led to considerable success in the treatment of a number of incurable and quickly lethal rare cancers. This gave rise in the 1970's to a high expectation that Chemotherapy would provide a much needed breakthrough in the search for a cure for cancer. This optimism has led to a significant extension of the modality beyond the above known limits of successful use and created a climate which strongly supports this experimental application, although a small but increasing number of voices now challenge the legitimacy of this belief. This research explores a number of ethical issues which now arise from the continued use of this treatment modality. The discussion will center on three issues. These will be, firstly, the integrity of the treatment modality, secondly, the concerns about the experience of Chemotherapy on the individual and their family, and thirdly, the concerns involved in the public presentation of Chemotherapy and the lack of public debate. As a basis for understanding the ethical concepts used in this study into the Bioethics of Chemotherapy, a broad background of information on the relevant aspects of Normative Ethics is provided, at the beginning of this discussion. A study of the newspaper reporting of Chemotherapy is included to extend the discussion of the third issue, that of the public presentation of Chemotherapy.In conclusion, an open ended, four step plan for action is recommended.
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Mulholland, K. C. "Experimental chemotherapy-induced mucositis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479433.

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Bates, Robert W. "Prodrugs for cancer chemotherapy." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333294.

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Morris, D. L. "Chemotherapy of hydatid disease." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374320.

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Taylor, Duncan Hugh. "Chemotherapy of Echinococcus species." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252947.

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Lindner, Oana. "Chemotherapy-induced cognitive changes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/chemotherapyinduced-cognitive-changes(48ea95ea-4510-41b6-850e-72e733747c7c).html.

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The present thesis, entitled Chemotherapy-induced cognitive changes, is being submitted in the alternative format, by Oana Calina Lindner to The University of Manchester for the degree of Doctor of Philosophy in the Faculty of Medical and Human Sciences, School of Psychological Sciences. The thesis consists of five empirical studies, written in article formats and three connecting chapters. The General introduction in Chapter 1, places the thesis in the context of late effects research in cancer survivors. I describe the prevalence of physical and emotional late effects, before going into more details on cognitive late effects. Chapter 2 provides a meta-analytical summary of cognitive impairments following chemotherapy in adult patients. It has already been published in Neuropsychology in 2014. Chapter 3 describes the general objectives and hypotheses of the empirical studies, and Chapter 4 provides more details on the General methods utilized in all the studies. The studies focus on pre- and post-treatment young adult cancer patients who were compared to age-, sex-, and education-matched controls. The instruments include a comprehensive neuropsychological battery, a newly designed memory task, and a complex battery of self-assessment questionnaires. Chapter 5 is the first empirical study, which will be submitted to Journal of Clinical Oncology. It describes the pattern of neuropsychological status of young adult cancer patients following treatment for lymphoma, sarcoma, breast cancer, and germ cell tumour. The impairments were specific to executive functioning, verbal memory, and visuospatial abilities. Uniquely, the chapter depicts differences between cancer groups. Because chemotherapy may not be the primary factor triggering such effects, Chapter 6 details the neuropsychological profile of a group of young adult pre-treatment patients diagnosed with the same malignancies. This chapter will be submitted to Journal of Neuropsychology. Impairments were observed on tests of attention, executive functioning and visuospatial abilities. Both Chapters 5 and 6 emphasize the importance of matching on full scale IQ in cross-sectional studies and they provide evidence that patients' performance on tests of verbal memory and executive functioning may vary as a function of age. Chapter 7 will be submitted to Psycho-Oncology and it suggests the presence of acute memory deficits after the first treatment. Finally, Chapter 8, which will be submitted to Psychosomatic Medicine, provides an in-depth description of the psycho-emotional status of cancer survivors. It describes higher levels of anxiety, depression, fatigue, and cognitive complaints, which mediated the relationship between illness perceptions and quality of life. The complex interaction between these psycho-emotional factors is interpreted within the framework of cognitive-behavioural therapies, which may provide a method to decrease the emotional burden of survivorship in clinical practice. Finally, Chapter 9 summarizes all the empirical findings whilst connecting them to previous literature and specifying future research direction.
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Tintoré, Gazulla Maria. "hAGT inhibitors as chemotherapy enhancers." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/299794.

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The O6-alkylguanine DNA alkyltransferase (hAGT or MGMT) is a DNA repair protein in charge of removing alkyl adducts from the O6 position of guanines, blocking their cytotoxic effects and playing an important role as a resistance mechanism to chemotherapy in cancer patients. For these reasons, it is considered relevant as a prognosis marker of cancer and represents a potential therapeutic target. Intense research efforts have been devoted to the identification of small molecules capable of inhibiting hAGT activity and enhancing the cytotoxic effect of the alkylating agents in tumour cells. In this doctoral thesis, we have explored 10 compounds with potential inhibitory activity against hAGT. The analysis by mass spectrometry (ESI-MS) confirmed the complex formation of hAGT with 5 of them (compounds 5, 6, 7, 8 and 9). MTT cytotoxicity studies in cell culture showed that 2 compounds (5 and 8) were non-toxic and showed enhancement of carmustine toxicity. This compounds were further analysed by colony formation assays, which confirmed that compound 8 was non-toxic at long-term experiments and exhibited a stimulation effect of carmustine. Compound 8 seem to be the best candidates for hAGT inhibition, as it forms a complex with hAGT and it enhances BCNU without being toxic in MTT and colony formation assays. Due to the lack of a consistent in vitro assay for the activity of hAGT, we have devoted part of this doctoral thesis to the search of bio and nanotechnologies to detect hAGT activity which enable the evaluation of potential inhibitors of the protein. Chapter 2 describes the development of a new fluorescence method using the conformational change of a DNA Gquadruplex, the thrombin binding aptamer (TBA), as a molecular beacon for the detection of hAGT activity and the development of new inhibitor compounds. The conformational change of TBA is further explored to develop a detection platform on DNA origami which allows de quantification of the repair activity of hAGT on a single molecules basis, through the direct visualization by AFM of the interaction of TBA-thrombin when its G-quadruplex structure is restored. In addition, this work reports the synthesis of guanine derivatives modified at position 6 and properly functionalized for their incorporation into double stranded oligonucleotides that are used for the development of another novel fluorescence methodology to evaluate hAGT activity and to assess potential inhibitors as enhancers of chemotherapy. Finally, during a short stay in the University of Milan, we have developed a new sensor to detect a methylation in TBA using three types of nanoparticles: AuNPs, SPIONs and AuSPIONs. AuSPIONs combine the features of the gold coating and the magnetic core, and exhibit similar performance as AuNPs and SPIONs in UV, DLS and MRI assays to detect thrombin and a single methylation in TBA. Ths results provide the basis for the development of a new straightforward method to study hAGT activity and to evaluate potential inhibitors.
La proteïna de reparació de l’ADN alquilguanina-ADN-O6-alquiltransferasa (hAGT) elimina productes d'alquilació en la posició O6 de les guanines, bloquejant la citotoxicitat dels agents alquilants i produint resistència a la quimioteràpia. Es considera rellevant com a marcador de pronòstic en càncer i representa una potencial diana terapèutica. L’objectiu a llarg termini d’aquesta tesi doctoral és trobar inhibidors de l’activitat d’hAGT per millorar l'efecte de la quimioteràpia en pacients amb càncer. En primer lloc, es va avaluar la capacitat de 10 compostos, potencials inhibidors d’h!GT, de formar un complexe amb hAGT utilitzant espectrometria de masses, i es va estudiar la seva toxicitat en cultius cel·lulars a través d'assajos de MTT i de formació de colònies. A continuació, es desenvolupen diferents mètodes per a la detecció de l’activitat d’hAGT, per a avaluar els potencials inhibidors d’aquesta proteïna in vitro. Dos d’aquests mètodes utilitzen el canvi conformacional que es produeix en l’aptàmer d’unió a la trombina (TBA) en introduir una O6-metilguanina, substracte d’hAGT, en una de les seves tètrades centrals. En el primer mètode es va emprar el TBA per generar un sensor de fluorescència incorporant un fluoròfor i un inhibidor de fluorescència a cadascun dels seus extrems. Aquest sensor permet la detecció de la disminució en la fluorescència deguda al canvi conformacional del TBA produït per l’activitat d’hAGT. Posteriorment, el canvi conformacional del TBA va permetre dissenyar un biosensor de l'activitat d'hAGT a nivell unimolecular sobre la superficie d’un origami d'ADN. La interacció del TBA amb la seva proteïna diana, l’alfa-trombina, es va seguir per AFM per detectar que l’estructura de G-quàdruplex metilada es restableix per la reparació d’hAGT. El tercer mètode es basa en la transferència de fluorescència al centre actiu d’h!GT degut a la reparació d’un oligonucleòtid que conté una guanina modificada amb un grup alquil marcat amb un fluoròfor. Amb aquest objectiu, es va portar a terme la síntesi química d’aquesta guanina modificada. En el marc d’una estada en la Universitat de Milà, es descriu l’estudi de nanopartícules funcionalitzades amb TBAs per a detectar una metilació en una guanina utilitzant espectroscòpia d’UV, DLS o MRI, amb l’objectiu de desenvolupar un nou assaig de l’activitat reparadora d’ADN d’h!GT.
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Prytz, Anna, and Linda Harnfeldt. "Chemotherapy and Cancer - childrens experiences." Thesis, Kristianstad University College, Department of Health Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-3754.

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With good knowledge about the disease and the treatment, the fear and worry of children and parents can be reduced. Children may be helped by painting to express their experiences. In order to have a good care, the care-personnel need to see and understand what the children need. It is important to live an as regular life as possible during the disease and its treatment. The aim of this study was to elucidate how children experience chemotherapy in conection with their cancer disease. The method that was chosen was an systematic literature review. The result was based on five qualitative articles, which could be divided into four categories: to feel afraid and worried, to feel limited, to feel different and to feel sick. Discussion: There is risk that important information that the children want to tell will go lost when parents and care-personnels communicate children’s experiences to a third part. There is reaserch telling that children may need an adult to help express their experiences.

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Fallon, Padraic G. "Experimental chemotherapy of Schistosoma mansoni." Thesis, Bangor University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240017.

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Sujendran, Vijay. "Neoadjuvant chemotherapy in oesophageal cancer." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501118.

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Neoadjuvant chemotherapy in oesophageal cancer has gained rapid favour in le United Kingdom over the past few years. It remains controversial outside the UK, with mixed results from clinical trials. The work in this thesis begins with a review of the literature on neoadjuvant chemotherapy, and of the antimetabolites and platinum agents used. The quantitative reverse transcriptase polymerase chain reaction (qRTPCR) used to identify molecular determinants of chemosensitivity is discussed followed by a look at the clinical experience of neoadjuvant chemotherapy at a single centre. Over the past six years 194 patients in Oxford have undergone neoadjuvant chemotherapy with cisplatin and 5-flurouracil. Six patients developed progressive disease, 12 patients stopped chemotherapy early, one patient died during chemotherapy and one patient had perforation of the oesophagus. Overall chemotherapy was well tolerated among patients with no significant increase in respiratory complications and anastomotic leak following the use of neoadjuvant chemotherapy. Following the advent of neoadjuvant chemotherapy, there has been a significant decrease in circumferential resection margin involvement, compared to historical controls. Locoregional recurrence and overall survival have also improved. Cox's multivariate analysis shows circumferential resection margin to be an independent prognostic factor for locoregional recurrence and overall survival.
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Books on the topic "Chemotherapy"

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Bardhan-Quallen, Sudipta. Chemotherapy. San Diego: Thomson/Gale, 2004.

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Challand, Richard. Antiviral chemotherapy. Oxford: Spektrum, 1997.

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Rosenthal, Philip J. Antimalarial Chemotherapy. New Jersey: Humana Press, 2001. http://dx.doi.org/10.1385/1592591116.

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Aigner, Karl Reinhard, and Frederick O. Stephens, eds. Induction Chemotherapy. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28773-7.

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Aigner, Karl Reinhard, and Frederick O. Stephens, eds. Induction Chemotherapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18173-3.

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Metzger, Urs, Felix Largiadèr, and Hans-Jörg Senn, eds. Perioperative Chemotherapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-82432-6.

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Markman, Maurie, ed. Regional Chemotherapy. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-219-7.

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Bocci, Guido, and Giulio Francia, eds. Metronomic Chemotherapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-43604-2.

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Priestman, Terry J. Cancer chemotherapy. 3rd ed. London: Springer-Verlag, 1989.

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1946-, Laffer U., Weber-Stadelmann Walter, and Metzger U. 1945-, eds. Regional chemotherapy. Basel: Karger, 1988.

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Book chapters on the topic "Chemotherapy"

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Rodriguez-Galindo, Carlos. "Chemotherapy." In Pediatric Head and Neck Tumors, 23–30. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8755-5_3.

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Gritsenko, Karina, and Michael Lubrano. "Chemotherapy." In Essentials of Interventional Cancer Pain Management, 19–27. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99684-4_4.

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Goldstein, Bram. "Chemotherapy." In Encyclopedia of Clinical Neuropsychology, 753–55. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_98.

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Ramina, Ricardo, and Marcos Soares Tatagiba. "Chemotherapy." In Tumors of the Jugular Foramen, 163–67. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43368-4_13.

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Duffaud, F., P. Fumoleau, and R. Favre. "Chemotherapy." In Bone Metastases, 31–42. London: Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3251-6_3.

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Jasmin, Claude, Marjorie C. Green, and Gabriel N. Hortobagyi. "Chemotherapy." In Textbook of Bone Metastases, 259–75. Chichester, UK: John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470011610.ch20.

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Yamada, Yu. "Chemotherapy." In Encyclopedia of Behavioral Medicine, 424–25. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_388.

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Yamada, Yu. "Chemotherapy." In Encyclopedia of Behavioral Medicine, 383–84. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_388.

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Nicolaides, Theodore, Biljana Horn, and Anuradha Banerjee. "Chemotherapy." In Pediatric Oncology, 317–42. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30789-3_15.

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Tohnai, Iwai, and Kenji Mitsudo. "Chemotherapy." In Oral Cancer, 319–33. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-54938-3_13.

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Conference papers on the topic "Chemotherapy"

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Levine, M., A. Arnold, L. Kelleher, S. Lord, W. Hryniuk, J. Hrish, and M. Gent. "CANCER CHEMOTHERAPY AND THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643203.

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Malignant disease is recognized as a risk factor for venous thromboembolism. A number of recent reports have suggested that cancer chemotherapy may contribute to this risk, but it was not possible to separate the role of chemotherapy from the effects of the malignant disease. We are conducting a randomized trial to determine the optimal duration of adjuvant chemotherapy in women with Stage II breast carcinoma. These ambulatory patients, with negligible tumour burden, receive either 12 weeks of chemo-hormonal therapy (cyclophosphamide, methotrexate, 5 fluorouracil, vincristine, prednisone, adriamycin and tamoxifen) or 36 weeks of chemotherapy (cyclophosphamide, methotrexate, 5 fluorouracil, vincristine and prednisone). This study has provided us with an opportunity to evaluate the thrombogenic effects of chemotherapy since patients in the 12 week group, while off chemotherapy, can be compared directly to the patients in the other group who are still on chemotherapy. This allows the confounding influence of the malignant process to be circumvented. All patients undergo screening tests for thrombosis (impedance plethysmography and Doppler ultrasound) and routine clinical assessments. Suspected venous thrombosis is confirmed by venography and suspected pulmonary embolism by either pulmonary angiography or high probability ventilation perfusion scanning. There have been 11 episodes of venous thromboembolism to date among 191 patients of whom 164 have completed the first 36 weeks of study. There were 3 episodes in each group during the first 12 weeks. During the subsequent 24 weeks there have been no events in the group whose treatment was stopped and 5 events in the group still on treatment (p 0.03). These findings demonstrate that chemotherapy per se is an important risk factor for venous thromboembolism in patients with malignant disease.
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Punt, Cornelis, and Robert van den Heuvel. "Triplet chemotherapy beats doublet chemotherapy in colorectal cancer liver metastases." In ASCO Annual Meeting 2022, edited by Cornelis Punt and Stefan Rauh. Baarn, the Netherlands: Medicom Medical Publishers, 2022. http://dx.doi.org/10.55788/c49a680e.

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Sevinc, Suleyman. "planCT : Chemotherapy scheduling system." In 2009 14th National Biomedical Engineering Meeting. IEEE, 2009. http://dx.doi.org/10.1109/biyomut.2009.5130274.

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Chaucer, B., A. Stone, R. M. Davis, and B. S. Aulakh. "Fatal Chemotherapy-Induced Mucositis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4827.

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Detpittayanan, Tipaya, and Atthapon Jaishuen. "Adjuvant chemotherapy alone compared with chemotherapy plus radiotherapy for stage III endometrial carcinoma." In The 7th Biennial Meeting of Asian Society of Gynecologic Oncology. Korea: Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology; Japan Society of Gynecologic Oncology, 2021. http://dx.doi.org/10.3802/jgo.2021.32.s1.e01.

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Johal, Sukhvinder, Miguel Miranda, Tina Sarbajna, Xiaojin Shi, Alastair Greystoke, and Melissa Johnson. "581 Matching-adjusted indirect treatment comparison of tremelimumab + durvalumab + chemotherapy vs pembrolizumab + chemotherapy and nivolumab + ipilimumab + chemotherapy for first-line metastatic NSCLC." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0581.

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Wroblewska, Hanna Piotrzkowska, Ziemowit Klimonda, Katarzyna Dobruch-Sobczak, Piotr Karwat, Wojciech Secomski, and Jerzy Litniewski. "Quantitative Ultrasound for Chemotherapy Monitoring." In 2018 Joint Conference - Acoustics. IEEE, 2018. http://dx.doi.org/10.1109/acoustics.2018.8502336.

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Ring, A. "Abstract ES4-2: Tailoring chemotherapy." In Abstracts: Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 8-12, 2015; San Antonio, TX. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.sabcs15-es4-2.

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Kumar, Siva. "Neoadjuvant chemotherapy in epithelial ovarian cancer: Largest single institute experience." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685313.

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Purpose: Neoadjuvant chemotherapy followed by interval debulking surgery (IDS) is an alternative treatment option, compared to the current standard of care primary debulking surgery for treating advanced epithelial ovarian cancer (EOC). We present our institute experience of neoadjuvant chemotherapy strategy in the management of EOC which is one of the largest single institute experience. Methods: This is a retrospective analysis of patients with epithelial ovarian cancer who were treated in our institute between 2000 and 2006. Patient with advanced disease by clinical and imaging were treated with 3 cycles of neoadjuvant chemotherapy and then taken up for interval debulking surgery (IDS) who had static or partial or complete response to chemotherapy. The remaining chemotherapy is delivered after the surgery. Patient who had limited disease had primary debulking surgery and then adjuvant chemotherapy according to institute protocol. Outcomes in terms of disease free and overall survival were analysed. Results: This retrospective analysis included 59 patients with limited disease who had primary debulking surgery and 283 patients with advanced disease who received neoadjuvant chemotherapy. The median age was 50 years and majority are in the 50-59 years age group. Age more than 60 years represent 14.5%. Postmenopausal women were55.3 % and premenopausal women were 44.7 %. Multiparity is higher 70.2% than the uniparity 16.4% ornulliparity 11.7%. Abdomen distension 42% and pain 25 % are the most common symptoms. Advanced stage was the most common presentation 71% with stage III-56.1% and stage IV-14.9%. Among the neoadjuvant chemotherapy group 126/283(44.5%) had optimal cytoreduction, 44/283 (15.5%) had suboptimal cytoreduction and 113/283 (40%) not suitable for IDS. The 5 year disease free and overall survival was 30.8% and 41.5% in the NACT group with advanced disease and 58.5% and 75.8% in the primary cytoreduction group who had limited diseaserespectively. The 5 years overall survival among the IDS group with optimal cytoreduction was 57.1% and 11.7% for the suboptimal cytoreduction group. The 5 years survival was not affected by the number of neoadjuvant chemotherapy cycles delivered before surgery in the IDS group. Patient who received paclitaxol + carboplatin as first line chemotherapy had better survival than carboplatin alone or cyclophosphamide + cisplatin. Conclusion: NACT as an alternative option to primary debulking surgery in operable EOC is still debatable. But for patient with high disease burden where optimal cytoreduction is not possible NACT strategy is a valid option. Recent randomised controlled trials from Europe had shown the noninferiority of neoadjuvant chemotherapy followed by IDS when compared to the primary debulking surgery in operable advanced EOC.
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Vieira, Natália Barros Salgado, Sarah Joanny da Silva Pereira, and Ana Flávia Silva Castro. "Neurocognitive Implications in Children Undergoing Chemotherapy and Radiotherapy." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.499.

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Background: Radiotherapy and chemotherapy drugs were essential for increasing the survival rates of pediatric cancer patients, but dysfunctions associated with treatment, mainly neurological and cognitive, are recorded and should be considered in deciding the therapeutic plan. Objectives: Analyze the current literature on the neurocognitive effects in children undergoing chemotherapy and radiation therapy. Methods: A bibliographic review was carried out in the MEDLINE / Pubmed and LILACS databases, using the terms “cognitive effects”, “chemotherapy”, “radiotherapy” and “child”, in Portuguese and in English. 79 articles were found and 6 followed for complete analysis. Articles published more than 5 years ago and that did not address the proposed subject were not used. Results: Radiotherapy, especially cranial (CRT), is associated with serious effects, such as induction of vasculopathy, stroke, cerebrovascular malformations, in addition to an increased risk for subsequent malignant CNS tumors. Despite being a standard treatment for several neoplasms, radiotherapy has been replaced, when possible, by higher doses of chemotherapy, which has a considerable level of neurotoxicity, capable of causing coagulopathy, encephalopathy, seizures and neuropathies, both sensory and motor. However, deficits in children’s attentional capacity in both treatment categories stood out, sometimes implying educational difficulties and decline in non-verbal skills. Conclusions: Although chemotherapy and radiation therapy represent impressive advances, their consequences remain a concern. Future studies should seek strategies for prevention, early recognition and management of neurotoxicity, in order to promote better life quality for patients.
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Reports on the topic "Chemotherapy"

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Peters, Wallace. Chemotherapy of Rodent Malaria. Fort Belvoir, VA: Defense Technical Information Center, October 1988. http://dx.doi.org/10.21236/ada228273.

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Shu, Yefei, Xiaofeng Xu, Wei Yang, and Ling Xu. Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: A Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0102.

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Moore, Sandra L. Antizyme Activation in Chemotherapy and Chemoprevention. Fort Belvoir, VA: Defense Technical Information Center, April 2002. http://dx.doi.org/10.21236/ada405302.

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Deborah Schrag, Deborah Schrag, Andrea Andrea Enzinger, Christine Cronin, and Jennifer Wind. Improving Informed Consent for Palliative Chemotherapy. Patient-Centered Outcomes Research Institute® (PCORI), August 2019. http://dx.doi.org/10.25302/7.2019.ce.13046517.

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Moore, Sandra L., and John L. Mitchell. Antizyme Activation in Chemotherapy and Chemoprevention. Fort Belvoir, VA: Defense Technical Information Center, March 2003. http://dx.doi.org/10.21236/ada420170.

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Porkka, Kimmo. Tumor Targeting Peptides for Cytotoxic Chemotherapy. Fort Belvoir, VA: Defense Technical Information Center, July 2000. http://dx.doi.org/10.21236/ada391964.

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Peters, Wallace. Chemotherapy of Rodent Malaria. Part 1. Fort Belvoir, VA: Defense Technical Information Center, October 1987. http://dx.doi.org/10.21236/adb121870.

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Peters, Wallace. Chemotherapy of Rodent Malaria. Part 2. Fort Belvoir, VA: Defense Technical Information Center, October 1987. http://dx.doi.org/10.21236/adb121871.

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Wang, Yan. For platinum-sensitive, recurrent ovarian cancer, secondary surgical cytoreduction combined with intravenous chemotherapy versus chemotherapy alone. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2021. http://dx.doi.org/10.37766/inplasy2021.7.0063.

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Lu, Yidan, Zheng Jin, Song Zheng, and Yurong Bai. Hyperthermic Intraperitoneal Chemotherapy combined with systemic chemotherapy versus systemic chemotherapy alone for Gastric Cancer Peritoneal Carcinomatosis: a systematic review and meta-analysis of randomised controlled trials. International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2020. http://dx.doi.org/10.37766/inplasy2020.5.0006.

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