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Journal articles on the topic 'Chemonucleolysis'

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Published: 4 June 2021
Last updated: 8 February 2022

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1

Graham, Edmund. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 494–95. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121207.x.

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2

Werth, Peter D. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 495–96. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121208.x.

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3

Taylor, Thomas K. F., Peter Ghosh, and James Melrose. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 496. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121209.x.

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4

Rydevik, Björn, and Robert Deutman. "Chemonucleolysis." Acta Orthopaedica Scandinavica 64, no. 1 (January 1993): 124–26. http://dx.doi.org/10.3109/17453679308994550.

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5

Simmons, James W. "Chemonucleolysis." Journal of Bone & Joint Surgery 67, no. 9 (December 1985): 1454–55. http://dx.doi.org/10.2106/00004623-198567090-00032.

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6

&NA;. "Chemonucleolysis." Back Letter 3, no. 9 (July 1989): 2–3. http://dx.doi.org/10.1097/00130561-198907000-00002.

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7

Wright, P. H. "Chemonucleolysis." JAMA: The Journal of the American Medical Association 263, no. 7 (February 16, 1990): 948–49. http://dx.doi.org/10.1001/jama.263.7.948.

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8

Wright, Peter H. "Chemonucleolysis." JAMA: The Journal of the American Medical Association 263, no. 7 (February 16, 1990): 948. http://dx.doi.org/10.1001/jama.1990.03440070034021.

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9

JABAAY, GERALD A. "Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 24???31. http://dx.doi.org/10.1097/00003086-198605000-00006.

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10

THOMAS, JAMES C., LEON L. WILTSE, ERIC H. WIDELL, C. W. SPENCER, MICHAEL R. ZINDRICK, and B. TED FIELD. "Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 61???66. http://dx.doi.org/10.1097/00003086-198605000-00013.

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11

SMITH, LYMAN. "Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 287 (February 1993): 117???124. http://dx.doi.org/10.1097/00003086-199302000-00019.

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12

Javid, Manucher J. "A 1- to 4-year follow-up review of treatment of sciatica using chemonucleolysis or laminectomy." Journal of Neurosurgery 76, no. 2 (February 1992): 184–90. http://dx.doi.org/10.3171/jns.1992.76.2.0184.

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✓ To help clarify the comparative effects of chemonucleolysis and discectomy, the author studied 178 consecutive patients with sciatica who did not respond to conservative treatment. None had previously undergone laminectomy or chemonucleolysis or had spinal stenosis. All received postmyelography computerized tomography (CT) and, if the radiological interpretation was that of an extruded migrated disc, a laminectomy was performed; otherwise, the patient was given a choice of the two procedures. Of the 178 patients, 106 underwent chemonucleolysis and 72 laminectomy. Workers' compensation was being paid to 21.6% of the chemonucleolysis patients and 20.8% of the laminectomy patients. Postoperatively, substantial improvement was noted in 82.7% of the chemonucleolysis patients and 92.5% of the laminectomy patients at 6 weeks and in 92.8% of the chemonucleolysis patients and 89.7% of the laminectomy patients at 6 months. The majority of patients in both groups had improved neurological signs. Follow-up questionnaires at 1 to 4 years postoperatively revealed an overall success rate of 86.5% for chemonucleolysis patients and 83.8% for laminectomy patients. In patients not receiving workers' compensation, 90.1% of the chemonucleolysis patients and 88.6% of the laminectomy patients had a successful outcome; in those receiving workers' compensation, 69.6% of the chemonucleolysis patients and 60.0% of the laminectomy patients had a successful outcome. No statistically significant differences in improvement rate in neurological symptoms or signs were identified between the two procedures. Overall, 85.1 % of the chemonucleolysis patients and 78.5% of the laminectomy patients were employed at follow-up review. To achieve optimum results and eliminate noncandidates for chemonucleolysis, routine use of postmyelography CT is recommended. When properly used, chymopapain chemonucleolysis is an acceptable alternative to surgical discectomy.
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13

Maroon, Joseph C., and Adnan Abla. "Microdiscectomy versus Chemonucleolysis." Neurosurgery 16, no. 5 (May 1, 1985): 644–49. http://dx.doi.org/10.1227/00006123-198505000-00010.

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Abstract A retrospective analysis of 50 consecutive patients treated with chemonucleolysis and 50 treated with microlumbar discectomy was carried out. Similar clinical criteria for the diagnosis of “virgin” herniated lumbar discs were used. All patients had low back or radicular pain unrelieved by a minimum of 4 weeks of conservative therapy. Physical findings included a positive straight leg raising sign, weakness of the appropriate muscle groups, and a sensory loss or evidence of depressed reflexes. All had myelograms or computed tomographic scans demonstrating an extradural defect. Compensation cases were eliminated. Results demonstrated a 90% marked improvement in the microdiscectomy category and a 58% marked improvement in the chemonucleolysis group. Four per cent of the microdiscectomy patients were unimproved, and 18% of the chemonucleolysis group required a subsequent surgical procedure. The average postoperative hospital stay was 3 days for both groups. Because of the necessity for reoperations in the chemonucleolysis group, chemonucleolysis seemed less cost-effective than microdiscectomy.
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14

Konings, Joop G. "Chymopapain chemonucleolysis." Acta Orthopaedica Scandinavica 64, sup251 (January 1993): 27–29. http://dx.doi.org/10.3109/17453679309160110.

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15

&NA;. "Chemonucleolysis Redux." Back Letter 8, no. 8 (1993): 1. http://dx.doi.org/10.1097/00130561-199308080-00001.

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16

Batson, Eric P. "Chemonucleolysis-Reply." JAMA: The Journal of the American Medical Association 263, no. 7 (February 16, 1990): 948. http://dx.doi.org/10.1001/jama.1990.03440070034022.

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17

SUTTON, J. CARL. "Repeat Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 45???49. http://dx.doi.org/10.1097/00003086-198605000-00010.

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18

Atilola, Matthew A. O., Joe P. Morgan, Cleta Sue Bailey, and Takayoshi Miyabayashi. "CANINE CHEMONUCLEOLYSIS." Veterinary Radiology 29, no. 4 (July 1988): 168–75. http://dx.doi.org/10.1111/j.1740-8261.1988.tb01770.x.

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19

Guha, Abhijit Ranjan, Ujjwal Kanti Debnath, and Sunil D??Souza. "Chemonucleolysis Revisited." Journal of Spinal Disorders & Techniques 19, no. 3 (May 2006): 167–70. http://dx.doi.org/10.1097/01.bsd.0000182233.74524.bb.

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20

Deutman, Robert. "(iv) Chemonucleolysis." Current Orthopaedics 9, no. 2 (April 1995): 106–10. http://dx.doi.org/10.1016/0268-0890(95)90069-1.

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21

Gomez-Castresana, F. B., C. Vazquez Herrero, and J. L. Baltes Horche. "CERVICAL CHEMONUCLEOLYSIS." Orthopedics 18, no. 3 (March 1995): 237–42. http://dx.doi.org/10.3928/0147-7447-19950301-04.

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22

van Alphen, H. August M., Reinder Braakman, P. Dick Bezemer, Gijs Broere, and M. Willem Berfelo. "Chemonucleolysis versus discectomy: a randomized multicenter trial." Journal of Neurosurgery 70, no. 6 (June 1989): 869–75. http://dx.doi.org/10.3171/jns.1989.70.6.0869.

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✓ A randomized clinical trial was carried out to compare the results of open discectomy with those of chemonucleolysis in 151 patients suffering from a disc herniation at L4–5 or L5–S1. All patients fulfilled strict entry criteria; 78 patients underwent open discectomy and 73 were subjected to chemonucleolysis. An increase in radicular pain immediately after treatment was encountered in 16 patients (22%) in the chemonucleolysis group, as compared to none in the discectomy group. The efficacy of discectomy appeared to be definitely superior to that of chemonucleolysis. Within a follow-up period of 1 year, 18 patients (25%) required open discectomy following failed chemonucleolysis; two patients (3%) in the discectomy group needed a second operation. Open discectomy following previous chemonucleolysis was successful in only 44% of cases. Comparison of the final results of the two modes of treatment 12 months after the last intervention (including second treatment) did not reveal any significant differences. The duration of the preoperative symptoms, the level of disc herniation, and the leakage of contrast medium out of the disc appeared to be of no relevance to the final outcome. The complication rates in both treatment groups were low.
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23

Stagni, S., F. De Santis, L. Cirillo, M. Dall'Olio, C. Princiotta, L. Simonetti, A. Stafa, and M. Leonardi. "A Minimally Invasive Treatment for Lumbar Disc Herniation: DiscoGel® Chemonucleolysis in Patients Unresponsive to Chemonucleolysis with Oxygen-Ozone." Interventional Neuroradiology 18, no. 1 (March 2012): 97–104. http://dx.doi.org/10.1177/159101991201800113.

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A multitude of therapies is available to treat disc herniation, ranging from conservative methods (medication and physical therapy) to minimally invasive (percutaneous) treatments and surgery. O2-O3 chemonucleolysis (O2-O3 therapy) is one of the minimally invasive treatments with the best cost/benefit ratio and lowest complication rate. Another substance recently made available exploiting the chemical properties of pure ethanol is DiscoGel®, a radiopaque gelified ethanol more viscous than absolute alcohol 8,9. The present study aimed to assess the therapeutic outcome of DiscoGel® chemonucleolysis in patients with lumbar disc herniation unresponsive to O2-O3 therapy. Thirty-two patients aged between 20 and 79 years were treated by DiscoGel® chemonucleolysis between December 2008 and January 2010. The treatment was successful (improvement in pain) in 24 out of 32 patients. DiscoGel® is safe and easy to handle and there were no complications related to product diffusivity outside the treatment site. The therapeutic success rate of DiscoGel® chemonucleolysis in patients unresponsive to O2-O3 therapy was satisfactory. Among other methods used to treat lumbar disc herniation, DiscoGel® chemonucleolysis can be deemed an intermediate procedure bridging conservative medical treatments and surgery.
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24

Onofrio, Burton M. "Focus on Chemonucleolysis." Mayo Clinic Proceedings 62, no. 7 (July 1987): 641–42. http://dx.doi.org/10.1016/s0025-6196(12)62316-7.

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25

Maroon, J. C., and A. Abla. "Microdiscectomy versus chemonucleolysis." Neurosurgery 16, no. 5 (May 1985): 644???9. http://dx.doi.org/10.1097/00006123-198505000-00010.

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26

Wilkinson, H. A. "Microdiscectomy vs. chemonucleolysis." Neurosurgery 17, no. 6 (December 1985): 1016. http://dx.doi.org/10.1097/00006123-198512000-00028.

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27

Chicheportiche, Valerie, Caroline Parlier-Cuau, Pierre Champsaur, and Jean-Denis Laredo. "Lumbar Chymopapain Chemonucleolysis." Seminars in Musculoskeletal Radiology 1, no. 02 (1997): 197–206. http://dx.doi.org/10.1055/s-2008-1080139.

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28

Krause, Denis, J. Grafé, D. Maithôr, and J. Tongio. "Cervical Chymopapain Chemonucleolysis." Seminars in Musculoskeletal Radiology 1, no. 02 (1997): 207–14. http://dx.doi.org/10.1055/s-2008-1080140.

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29

van Leeuwen, R. B., P. H. Hoogland, and A. W. de Weerd. "Chemonucleolysis; Predictive Factors." Spine 17, no. 7 (July 1992): 838–41. http://dx.doi.org/10.1097/00007632-199207000-00019.

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30

Javid, Manucher J. "Chemonucleolysis Versus Laminectomy." Spine 20, no. 18 (September 1995): 2016–22. http://dx.doi.org/10.1097/00007632-199509150-00013.

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31

&NA;. "Chemonucleolysis for Spondylolisthesis?" Back Letter 13, no. 3 (March 1998): 30–31. http://dx.doi.org/10.1097/00130561-199803000-00008.

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32

KITCHEL, SCOTT H., and MARK D. BROWN. "Complications of Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 284 (November 1992): 63???74. http://dx.doi.org/10.1097/00003086-199211000-00009.

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33

DYCK, PETER. "Paraplegia Following Chemonucleolysis." Spine 10, no. 4 (May 1985): 359–62. http://dx.doi.org/10.1097/00007632-198505000-00012.

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34

Nordby, Eugene J., Robert D. Fraser, and Manucher J. Javid. "Spine Update Chemonucleolysis." Spine 21, no. 9 (May 1996): 1102–5. http://dx.doi.org/10.1097/00007632-199605010-00023.

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35

Romy, Maurice. "Open letter to surgeons performing chemonucleolysis (from a surgeon performing chemonucleolysis)." Surgical Neurology 24, no. 5 (November 1985): 587. http://dx.doi.org/10.1016/0090-3019(85)90279-4.

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36

Javid, Manucher J. "Efficacy of chymopapain chemonucleolysis." Journal of Neurosurgery 62, no. 5 (May 1985): 662–66. http://dx.doi.org/10.3171/jns.1985.62.5.0662.

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✓ A 9- to 12-year follow-up review was conducted in 105 of 124 patients who were treated with chymopapain chemonucleolysis for herniated lumbar disc. The data were obtained from responses to a questionnaire. Seventy-nine patients (75.2%) reported marked improvement, six (5.7%) had slight improvement, and 20 (19.0%) had no improvement. Of the 87 patients not receiving workman's compensation, 70 patients (80.5%) had marked improvement; four (4.6%) had slight improvement; and 13 (14.9%) had no improvement. Of the 18 compensation cases, nine patients (50.0%) had marked improvement; two patients (11.1%) had slight improvement; and seven patients (38.9%) had no improvement. These results are comparable to those reported for surgical discectomy, and confirm that chymopapain chemonucleolysis is an alternative to surgery.
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37

Berkson, B., M. G. Zakhary, M. L. Primack, and R. Firfer. "Urological Complications Following Chemonucleolysis." Journal of Urology 133, no. 6 (June 1985): 1065–66. http://dx.doi.org/10.1016/s0022-5347(17)49381-5.

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38

WEINSTEIN, JAMES N., T. R. LEHMANN, W. HEJNA, THOMAS MCNEILL, and K. SPRATT. "Chemonucleolysis Versus Open Discectomy." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 50???55. http://dx.doi.org/10.1097/00003086-198605000-00011.

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39

MOSS, JONATHAN, and MICHAEL F. ROIZEN. "Adverse Reactions to Chemonucleolysis." International Anesthesiology Clinics 23, no. 3 (1985): 119–32. http://dx.doi.org/10.1097/00004311-198511000-00008.

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40

MOSS, JONATHAN, and MICHAEL F. ROIZEN. "Adverse Reactions to Chemonucleolysis." International Anesthesiology Clinics 23, no. 3 (1985): 119–32. http://dx.doi.org/10.1097/00004311-198523030-00008.

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41

BROWN, MARK D., and JANET S. TOMPKINS. "Chemonucleolysis (Discolysis) with Collagenase." Spine 11, no. 2 (March 1986): 123–30. http://dx.doi.org/10.1097/00007632-198603000-00004.

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42

NORTON, WAYNE L. "Chemonucleolysis Versus Surgical Discectomy." Spine 11, no. 5 (June 1986): 440–43. http://dx.doi.org/10.1097/00007632-198606000-00008.

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43

TAKAHASHI, KAZUHISA, SHUN-ICHI INOUE, SHUN-ICHI TAKADA, HIDEKI NISHIYAMA, MASAYA MIMURA, and YUICHI WADA. "Experimental Study on Chemonucleolysis." Spine 11, no. 6 (July 1986): 617–20. http://dx.doi.org/10.1097/00007632-198607000-00014.

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44

Brown, Mark D. "▪ Update on Chemonucleolysis." Spine 21, Supplement (December 1996): 62S—68S. http://dx.doi.org/10.1097/00007632-199612151-00007.

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45

AMICO, SALVATORE, JEAN PAUL ESCHARD, JEAN CLAUDE LIEHN, and JACQUES VALEYRE. "Bone Scan and Chemonucleolysis." Clinical Nuclear Medicine 15, no. 12 (December 1990): 908–10. http://dx.doi.org/10.1097/00003072-199012000-00012.

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46

Steffen, R., and R. von Bremen-Kühne. "Chemonucleolysis. Development, experience, perspectives." Der Orthopäde 28, no. 7 (July 1999): 609–14. http://dx.doi.org/10.1007/pl00003649.

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47

Cusick, Joseph F., Khang-Cheng Ho, and Jay F. Schamberg. "Subarachnoid hemorrhage following chymopapain chemonucleolysis." Journal of Neurosurgery 66, no. 5 (May 1987): 775–78. http://dx.doi.org/10.3171/jns.1987.66.5.0775.

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✓ Subarachnoid hemorrhage is a frequent finding in patients who have incurred neurological complications following chymopapain chemonucleolysis, but the basis for this occurrence remains controversial. The authors report the clinical and postmortem findings in a 42-year-old man who died 5 days after chemonucleolysis at the L4–5 and L5–S1 disc spaces. The predominant histological abnormality was a severe inflammatory arteritis of a medium-sized artery at the upper cervical level with disruption of the vessel wall. The potential causative role of chymopapain in this situation and the correlation of a vascular basis for many of the complications found after inadvertent intrathecal chymopapain injection are discussed.
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48

Tashiro, Kouichi, Naoya Tajima, Keiichiro Kawano, Kouichi Matsumoto, and Shinichiro Kubo. "Chemonucleolysis for Lumbar Disc Herniation." Orthopedics & Traumatology 37, no. 3 (1989): 1154–59. http://dx.doi.org/10.5035/nishiseisai.37.1154.

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49

Moon, Myung-Sang, In-Young Ok, and Sung-Soo Kim. "Chemonucleolysis in Lumbar Disc Disease." Journal of the Korean Orthopaedic Association 21, no. 2 (1986): 223. http://dx.doi.org/10.4055/jkoa.1986.21.2.223.

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50

Brautaset, N. J., and S. Hernminghytt. "Chemonucleolysis for herniated lumbar discs." Acta Neurologica Scandinavica 75, no. 6 (June 1987): 445. http://dx.doi.org/10.1111/j.1600-0404.1987.tb05483.x.

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