Academic literature on the topic 'Chemonucleolysis'

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Journal articles on the topic "Chemonucleolysis"

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Graham, Edmund. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 494–95. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121207.x.

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Werth, Peter D. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 495–96. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121208.x.

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Taylor, Thomas K. F., Peter Ghosh, and James Melrose. "Chemonucleolysis." Medical Journal of Australia 154, no. 7 (April 1991): 496. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121209.x.

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Rydevik, Björn, and Robert Deutman. "Chemonucleolysis." Acta Orthopaedica Scandinavica 64, no. 1 (January 1993): 124–26. http://dx.doi.org/10.3109/17453679308994550.

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Simmons, James W. "Chemonucleolysis." Journal of Bone & Joint Surgery 67, no. 9 (December 1985): 1454–55. http://dx.doi.org/10.2106/00004623-198567090-00032.

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&NA;. "Chemonucleolysis." Back Letter 3, no. 9 (July 1989): 2–3. http://dx.doi.org/10.1097/00130561-198907000-00002.

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Wright, P. H. "Chemonucleolysis." JAMA: The Journal of the American Medical Association 263, no. 7 (February 16, 1990): 948–49. http://dx.doi.org/10.1001/jama.263.7.948.

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Wright, Peter H. "Chemonucleolysis." JAMA: The Journal of the American Medical Association 263, no. 7 (February 16, 1990): 948. http://dx.doi.org/10.1001/jama.1990.03440070034021.

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JABAAY, GERALD A. "Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 24???31. http://dx.doi.org/10.1097/00003086-198605000-00006.

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THOMAS, JAMES C., LEON L. WILTSE, ERIC H. WIDELL, C. W. SPENCER, MICHAEL R. ZINDRICK, and B. TED FIELD. "Chemonucleolysis." Clinical Orthopaedics and Related Research &NA;, no. 206 (May 1986): 61???66. http://dx.doi.org/10.1097/00003086-198605000-00013.

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Dissertations / Theses on the topic "Chemonucleolysis"

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Fraser, Robert D. "Discitis after discography and chemonucleolysis /." Title page, table of contents and abstract only, 1986. http://web4.library.adelaide.edu.au/theses/09MD/09mdf842.pdf.

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Daibert, Ana Paula Falci. "Quimionucleólise cervical associada à fenda ventral em cães: avaliação clínico-cirúrgica, radiográfica e histológica." Universidade Federal de Viçosa, 2004. http://locus.ufv.br/handle/123456789/4994.

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The present study has as objectives to evaluate the clinical-surgical, radiological and histological aspects of canine cervical intervertebral disks after chemonucleolysis with chymopapain associated to the ventral slot. For that, it was used 24 dogs randomly divided into six equal groups. The ventral slot was accomplished in the area of the intervertebral disk C2-C3 and chemonucleolysis in the other cervical disks. Each group of four animals was submitted to euthanasia with an anesthetic overdose 24 hours, eight, 30, 60, 90 and 120 days after the enzyme injection and sagittal sections of the treated disks, associated to adjacent cartilaginous endplates and bony structures were obtained for histological analysis. The dogs were also monitored clinically and radiographically for up to 120 days, according to the groups. In this study, all dogs tolerated the surgical procedure, without detectable postoperative pain, neurological deficit or alteration of the conscience state. In the radiographic evaluation, it was observed consistent disk space narrowing 24 hours after the procedure and total absence of space from the eighth to the 90th day after chemonucleolysis in the area of all treated disks. However, at 120 days of postoperative there was an increase in disk height, corresponding, on average, to 59.13% of the preinjection value. Also, on the 30th day of postoperative, it was noted absorption of the vertebral bodies adjacent to the treated disks that progressed to healing, with evidences of vertebral fusion 120 days after the treatment. In the histological evaluation, it was observed 24 hours after disk injection nuclear digestion, characterized by cavitations and decrease of safranin-O staining intensity, indicating loss of proteoglycans. At eight days, the nuclear content was still vacuolated but more fibrillar. At 30 days, it was noted lesions and hemorrhage in the cartilaginous endplates. An irregularly defined mass in the nuclear space was observed on days 60th and 90th, but it seemed fibrocartilaginous tissue on day 120th. It was also observed microfractures and bone necrosis on day 90th, which were healed by day 120th. Chemonucleolysis with chymopapain associated to the ventral slot in the cervical column of dogs determines lysis of intervertebral disks, cervical instability and lesions of cartilaginous and bone adjacent structures that tend to repair with fibrocartilaginous tissue along the time.
Foram avaliados os aspectos clínico-cirúrgicos, radiográficos e histológicos de discos intervertebrais cervicais após quimionucleólise com quimiopapaína associada à fenda ventral. Foram utilizados 24 cães separados, aleatoriamente, em seis grupos iguais e de acordo com o tempo de observação pós-operatório. A fenda ventral foi realizada na região do disco intervertebral C2-C3 e as quimionucleólises nos demais discos cervicais. Cada grupo de quatro animais foi eutanasiado por sobredose anestésica 24 horas, oito, 30, 60, 90 e 120 dias após aplicação da enzima e foram obtidos cortes sagitais dos discos intervertebrais tratados, associados a estruturas cartilaginosas e ósseas adjacentes, para análise histológica. Os cães foram também avaliados, de acordo com o grupo, clinica e radiograficamente por até 120 dias. Todos os cães toleraram bem o procedimento cirúrgico, não apresentando déficit neurológico, alteração do estado de consciência e dor aparente na região cervical. Na avaliação radiográfica, com 24 horas, observou-se marcada redução da espessura dos espaços intervertebrais. Do oitavo ao 90º dia, foi verificada ausência total de espaço intervertebral na região de todos os discos tratados. Aos 120 dias, entretanto, as espessuras dos espaços intervertebrais correspondiam, em média, a 59,13% da espessura anterior ao procedimento. Ainda, radiograficamente, verificou-se aos 30 dias, absorção das porções dos corpos vertebrais adjacentes aos discos tratados, que progrediu para reparação, inclusive com evidências de fusão vertebral aos 120 dias. Na avaliação histológica, 24 horas após a quimionucleólise, foi observada digestão nuclear caracterizada por cavitações e redução da intensidade de coloração pela safranina-O, indicando perda de proteoglicanos. Aos oito dias, o conteúdo nuclear apresentou-se ainda vacuolizado, contudo mais fibrilar. Aos 30 dias, foram observadas lesões e áreas de hemorragia nas placas terminais cartilaginosas. A partir do 60º dia, notou-se a presença de material amorfo no espaço nuclear, que, aos 120 dias, tinha aparência de tecido fibrocartilaginoso. Aos 90 dias, verificou-se presença de microfraturas e osteonecrose, que estavam reparadas aos 120 dias. A quimionucleólise com quimiopapaína concomitante à fenda ventral na coluna cervical de cães determinou a lise dos discos intervertebrais, instabilidade cervical e lesões nas estruturas cartilaginosas e ósseas adjacentes, que tendem à reparação por tecido fibrocartilaginoso ao longo do tempo. Os trabalhos apresentados como parte integrante desta tese estão seguindo as normas de publicação do Arquivo Brasileiro de Medicina Veterinária e Zootecnia da Universidade Federal de Minas Gerais, indexada ao ISI, AGRIS, BIOSIS, CAB, CAS, MEDLARS e LILACS. ISSN 01020935.
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BENOIT, CHRISTIAN PAUL. "Nucleolyse : traitement des hernies discales ; etude et resultats des nucleolyses realisees a l'hopital de martigues de 1983 a 1988." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20369.

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GRUNSTEIN, GODON SOPHIE. "Traitement de la hernie discale par discolyse enzymatique." Amiens, 1989. http://www.theses.fr/1989AMIEM069.

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BADERE, JEAN-MARC. "Chimionucleolyse lombaire : revue de la litterature ; experience du c.h.u. de clermont-ferrand." Clermont-Ferrand 1, 1990. http://www.theses.fr/1990CLF13820.

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MILLOT, CHRISTOPHE. "Recidive de hernie discale apres chimionucleolyse a l'etage lombaire : a propos de 32 observations." Besançon, 1993. http://www.theses.fr/1993BESA3020.

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DESROUSSEAUX, JEAN-FRANCOIS. "Echecs de traitements invasifs de hernies discales lombaires : prise en charge chirurgicale ; etude d'une serie de 71 reprises." Lille 2, 1994. http://www.theses.fr/1994LIL2M089.

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LASCAUX, JEAN-JACQUES. "Devenir des hernies discales operees ou nucleolysees : deux lots comparables : sujet de moins de 40 ans, hernie discale avec signes cliniques et radiologiques, date par rapport a la chirurgie ou a la nucleolyse inferieure a trois mois." Limoges, 1988. http://www.theses.fr/1988LIMO0206.

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Thibault, Fabienne. "Nucléolyse cervicale à la chymopapaïne : à propos de 26 cas." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR1M150.

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Feuerstein, Philippe. "Discoscanner et nucléolyse lombaire : à propos de 75 cas." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M048.

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Books on the topic "Chemonucleolysis"

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Bonneville, Jean-François, ed. Focus on Chemonucleolysis. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4.

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1915-, Brown Joseph E., Nordby Eugene J, and Smith Lyman, eds. Chemonucleolysis. Thorofare, NJ: Slack, 1985.

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1943-, Bonneville Jean-François, ed. Focus on chemonucleolysis. Berlin: Springer-Verlag, 1986.

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Carl, Sutton J., Medi-Cine Communications International, and Royal Society of Medicine, eds. Current concepts in chemonucleolysis. London: Royal Society of Medicine, 1985.

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(Editor), R. H. Wittenberg, and R. Steffen (Editor), eds. Chemonucleolysis and Related Intradiscal Therapies. Thieme Publishing Group, 1994.

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Chemonucleolysis and related intradiscal therapies. Stuttgart: Georg Thieme Verlag, 1994.

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Book chapters on the topic "Chemonucleolysis"

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de Graaff, R. "Chemonucleolysis." In Verhandlungen der Deutschen Gesellschaft für Neurologie, 135–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-83201-7_30.

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Clère, P., M. Runge, and J. F. Bonneville. "Results after Chemonucleolysis." In Focus on Chemonucleolysis, 79–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_11.

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Deramond, H. "Failures of Chemonucleolysis." In Focus on Chemonucleolysis, 107–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_14.

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Eltorai, Ibrahim M. "Paraplegia Following Chemonucleolysis." In Rare Diseases and Syndromes of the Spinal Cord, 129–30. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45147-3_41.

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Benoist, M. "Principles of Chemonucleolysis Using Chymopapain." In Focus on Chemonucleolysis, 9–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_2.

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Roland, J., S. Bracard, D. Forlodou, C. Moret, and L. Picard. "Anatomical Aspects of the Intervertebral Disc." In Focus on Chemonucleolysis, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_1.

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Castagnera, L., B. Lavignolle, J. P. Claverie, B. Destribats, G. Macouillard, and J. Senegas. "Advantages of Disc Compliance Recording VS Discography." In Focus on Chemonucleolysis, 67–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_10.

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Laxenaire, M. C., and D. A. Monneret-Vautrain. "Anaphylactic Accidents Related to Chymopapain: Prevention and Treatment." In Focus on Chemonucleolysis, 87–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_12.

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Courtheoux, P., and J. Theron. "Complications of Nucleolysis." In Focus on Chemonucleolysis, 101–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_13.

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Houtteville, J. P., and K. Toumi. "Surgical Findings and Results After Chemonucleolysis Failure in Sciatica." In Focus on Chemonucleolysis, 115–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71182-4_15.

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Conference papers on the topic "Chemonucleolysis"

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Houseman, C., D. Chen, M. Scro, D. A. Grande, M. Levine, and N. O. Chahine. "Treatment of Intervertebral Disc With Chondroitinase-ABC Results in Reversible Degeneration in Rat Tail Model." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19247.

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Injury models of intervertebral disc provide a strong tool for studying the etiology of degenerative disc disease. Enzymatic degradation of the IVD with injection of chondroitinase ABC (ChABC) has been used in models of disc injury in rats, rabbits and goats [1–3], as well as used to induce repair of herniated discs in rabbits via chemonucleolysis [4, 7]. In a recent study, we investigated the dose effect of ChABC dosage on inducing disc degeneration [5]. Consistent with previous studies, our results found that a low dosage of ChABC (0.1 U/ml) resulted in decreased mechanical properties and glycosaminoglycan (GAG) content by 4 weeks post injections. Interestingly, when the dosage was increased to 10 U/ml, results indicated no measurable difference in GAG content or compressive mechanical properties after 4 weeks compared to sham saline injection or intact controls. These findings suggested that rat IVD was either unaffected by the enzymatic injection, or that it was capable of mounting a repair process after degradation with ChABC.
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Chahine, Nadeen, Nate Stetson, Neena Rajan, Daniel Grande, and Mitchell Levine. "Recovery of Intervertebral Disc Degeneration Post Enzymatic Treatment is Mediated by Matrix Metalloproteinases." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53887.

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Enzymatic degradation of the intervertebral disc (IVD) with chondroitinase ABC (ChABC) reduces proteoglycan content of the IVD, thus simulating the GAG loss seen clinically in patients suffering from disc degeneration. This approach has been employed in models of disc injury in rats, rabbits and goats when administered over a large range of dosages [1–3]. Moreover, ChABC has also been used to induce repair of herniated discs in rabbits via chemonucleolysis [4, 5]. Despite the effectiveness of ChABC treatment to reduce the GAG content of the IVD, several recent studies including our own, have shown that this GAG loss is reversible at extended time points post enzymatic treatment [2,6,7]. The goal of the current study is to examine the dose dependent response of IVDs to degradation by ChABC in vivo. We hypothesize that administration of ChABC will result in dose dependent GAG loss and reduced mechanical properties. We administered ChABC at 0.1 U/ml, 1.0 U/ml and 10 U/ml and examined the changes in biomechanical properties, biochemical content, and gene expression in order to examine the biophysical and molecular mechanism by which GAG loss occurs in this model.
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