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1
Saffer, Dylan. "Does Age Matter? Comparing CEO Age and Social Media Success in Startups." Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1685.
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In this paper, I examine the role of CEO age in predicting the success of startup firms, as measured by social media exposure. I use a novel measure of early-stage growth defined by increased levels of social media and online traction. I hypothesize that the age of the company’s CEO will be negatively correlated with their social media scores while controlling for the company’s total funding amounts and employee counts. My data consists of 250 United States-based startup companies that were founded between 2011 and 2015. Furthermore, they are all relatively successful in that they are still operating and have received between $100 thousand and $10 million of funding. I find that the social media score of a company is negatively impacted by the age of their CEO.
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Bouvier, Anthony. "The Effect of Age upon CEO Compensation: A Cross-Industry Study." Scholarship @ Claremont, 2010. http://scholarship.claremont.edu/cmc_theses/11.
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The compensation of CEO’s has been at the forefront of the public’s mind for the past few years. During the recession, one could not go a day without hearing about the atrocious salaries and bonuses that executives were being paid. Although it only recently became an explosive topic, academics have been researching all aspects of compensation for many years. One of the earliest looked at the idea of pay for performance (Jensen and Murphy 1990), and the field has taken off from there. Many studies have been done on the determinants of compensation, and I was interested in how age relates to compensation. I created a model for determining compensation, but also took it one step further and looked at the compensation structure across different industries as well. I found that age did indeed influence compensation levels, but that it only had some effect on pay structure and only in certain industries.
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D'Ewart, Brandon H. "The Effect of CEO Gender, Age, and Salary On Firm Value." Scholarship @ Claremont, 2015. http://scholarship.claremont.edu/cmc_theses/1059.
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This paper investigates the academic conclusions on how CEO gender and salary affect firm value, while at the same time adding data on how CEO age affects firm value. Via an event study of S&P 500 CEO changes from 2000 to 2006 I confirm the current academic findings and discover that CEOs promoted during their 40s negatively influence firm value, while CEOs in older age brackets show a positive abnormal return on firm value. With this validation and addition to the existing data, firms and investors can more effectively assess proper candidates for the position of CEO and allocate resources accordingly.
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Andersson, Fredrik, and Fredrik Lilja. "Earnings Management in times of CEO turnover : A quantitative study with the attributes – Industry, Company Size, CEO Origin, and CEO Age on the Swedish market." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202617.
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This thesis researches to which extent companies use earnings management in times of CEO turnover, which is a continuing, complex and rather complicated issue. Earnings management was tested on different attribute such as: firm industry, firm size, CEO’s age, and the CEO’s origin (internal or external). The data was gathered through a quantitative study based on public companies’ financial reports. The sample includes 252 firms listed on Nasdaq OMX Stockholm and have been subject of a CEO change at some occasion during 2005-2011. The statistical result from the mixed-model ANOVA tests showed in general significant result of upward earnings management the year of CEO change, but not the following year. While there are many explanations to the findings of how earnings management is used on the Swedish market, the analysis and conclusion elaborate the reason that ought to be the blueprint of reality.
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Wang, Hongxia. "Essays On CEO Turnover, Succession, And Compensation." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1879673281&sid=20&Fmt=2&clientId=1509&RQT=309&VName=PQD.
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Thesis (Ph. D.)--Southern Illinois University Carbondale, 2009."College of Business Administration." Keywords: CEO compensation, CEO succession, CEO turnover, Managerial discretion, Sarbanes-Oxley Act, Successor age. Includes bibliographical references (p. 112-124). Also available online.
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Christensen, Ryan T. "Age Effects on Iron-Based Pipes in Water Distribution Systems." DigitalCommons@USU, 2009. https://digitalcommons.usu.edu/etd/505.
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Pipes in water distribution systems may change as they age. The accumulation of corrosion byproducts and suspended particles on the inside wall of aged pipes can increase pipe roughness and reduce pipe diameter. To quantify the hydraulic effects of irregular accumulation on the pipe walls, eleven aged pipes ranging in diameter from 0.020-m (0.75-in) to 0.100-m (4-in) and with varying degrees of turberculation were located and subjected to laboratory testing. The laboratory test results were used to determine a relationship between pipe diameter reduction and Hazen-Williams C. This relationship, combined with a manipulation of the Hazen-Williams equation, provided a simple and direct method for correcting the diameters of aged pipes in distribution models. Using EPANET 2, the importance of correcting pipe diameters when modeling water distribution systems containing aged pipes was investigated. Correcting the pipe diameters in the sample network reduced the modeled water age by up to 10% and changed the pattern of fluctuating water age that occurred as waters with different sources moved through the pipe network. In addition, two of the aforementioned aged pipes with diameters of 0.025-m (1-in) and 0.050-m (2-in) were modeled using Reynolds-Averaged Navier-Stokes (RANS) turbulence modeling. Flow was computed at Reynolds numbers ranging from 6700 to 31,000 using three turbulence models including a 4-equation v2-f model, and 2-equation realizable k-e; and k-ω models. In comparing the RANS results to the laboratory testing, the v2-f model was found to be most accurate, producing Darcy-Weisbach friction factors from 5% higher to 15% lower than laboratory-obtained values. The capability of RANS modeling to provide a detailed characterization of the flow in aged pipes was demonstrated. Large eddy simulation (LES) was also performed on a single 0.050-m (2-in) pipe at a Reynolds number of 6800. The Darcy-Weisbach friction factor calculated using LES was 20% less than obtained from experimental tests. Roughness elements smaller than the grid scale and deficiencies in the subgrid-scale model at modeling the complex three-dimensional flow structures due to the irregular pipe boundary were identified as likely sources of error. Even so, the utility of LES for describing complex flows was established.
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Kopplin, Laura J. "The Identification of Genetic Risk Factors for Age-Related Macular Degeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251752708.
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Schmidt, Ricarda, Robert Richter, Anne Brauhardt, Andreas Hiemisch, Wieland Kiess, and Anja Hilbert. "Parental feeding practices in families with children aged 2-13 years: Psychometric properties and child age-specific norms of the German version of the Child Feeding Questionnaire (CFQ)." Elsevier, 2017. https://ul.qucosa.de/id/qucosa%3A34077.
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The Child Feeding Questionnaire (CFQ) is a self-report questionnaire for assessing parental attitudes to child weight and parental feeding practices. revious evaluations of its psychometric properties were conducted primarily with small to medium-sized samples ( N < 500) and a small range of children's age.
The present study aims to analyze the psychometric properties of the CFQ in a large German community sample and, for the first time, to establish normative data. Within the population-based LIFE Child study, the CFQ was administered to
N - 982 mothers of 2- to 13-year-old children. Psychometric analyses on
item statistics and internal consistency were conducted. Using structural equation modeling, four empirically-based factorial models of the CFQ were evaluated, and measurement invariance across child age groups and sex was examined. Age-specific norms for the CFQ subscales were computed. Item statistics were highly favorable for the majority of items, but floor and ceiling effects were found for 14 of 31 items. Internal consistency of the CFQ subscales ranged from acceptable to excellent (0.71< a < 0.91), except for the subscale Perceived Responsibility (a - 0.65). Regarding factorial validity, an eight-factor model with the newly created Reward subscale provided the best fit to the data. This model was factorial invariant across child sex and adjacent age groups. Maternal and child weight status showed large effects on CFQ subscale scores. The analyses established good psychometric properties for the German version of the CFQ and confirmed an eight-factor model. The provided norms allow for the comparison of individual parental feeding practices and change over time. The CFQ's sensitivity to
change and longitudinal associations of parental feeding practices and child weight status warrant further research.
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Geels, Alexis. "Assessing the late Holocene14C reservoir age of theChukchi Sea with the AniakchakCFE II tephra 3.6 kyr BP." Thesis, Stockholms universitet, Institutionen för naturgeografi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193090.
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Tephrochronology is a powerful tool to correlate and improve the chronology of sedimentaryarchives in the Arctic Ocean. The Aniakchak Caldera Forming Eruption (CFE) in Alaska at3.6 cal kyr BP ejected ash that were found in a widespread layer in Alaska, and as cryptotephrain the Chukchi Sea, Newfoundland, and Greenland. This study presents data from the coreSWERUS-L2-4-PC1 (4PC) taken at a water depth of 120 m in the Chukchi Sea. The sharp peakin tephra shards concentration permitted to clearly place the isochron. Unfortunately, the microprobeanalyses were unsuccessful, however measurements of trace elements were performedwith Laser Ablated-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS). The geochemicalsignature of the Aniakchak 3.6 eruption was ensured with significant trace elementratios. The isochron of the eruption combined with the radiocarbon dates from 4PC permittedto calculate the local marine radiocarbon reservoir age offset DR=36446 years. This value isrelatively low compared to recent estimates in the Chukchi Sea, especially to the neighbouringcore SWERUS-L2-2-PC1 were DR=47760. The DR value of this study is explained by theinfluence of the "young" Atlantic water mixing with the "old" Pacific water at the depth wherethe core was taken.
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Longville, Brooke Allison Cattell. "Genetic Epidemiology of Age-Related Macular Degeneration (AMD): The Role of the Complement Component 2 (C2) and Complement Factor B (CFB) Genes in Determining AMD Subphenotypes." Thesis, Longville, Brooke Allison Cattell (2009) Genetic Epidemiology of Age-Related Macular Degeneration (AMD): The Role of the Complement Component 2 (C2) and Complement Factor B (CFB) Genes in Determining AMD Subphenotypes. PhD thesis, Murdoch University, 2009. https://researchrepository.murdoch.edu.au/id/eprint/2438/.
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Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in people over the age of 50 in the developed world. Inflammation has a central role in the pathobiology of AMD; complement pathway dysfunction is thought to induce significant damage to macular cells, leading to atrophy, degeneration and the elaboration of choroidal neovascular membranes. The complement component 2 (C2) and complement factor B (CFB) genes are among several loci implicated though basic biology and genetic association studies in playing a significant role in determining susceptibility to AMD. The precise manner by which these genes affect AMD risk is unclear and largely theoretical. The purpose of this study was to examine the potential role of C2/CFB polymorphic genetic loci in determining the clinical severity of AMD and the manifestation of different AMD subphenotypes. Specifically, it was hypothesised that the C2/CFB genes are associated with AMD severity, independent of known AMD risk factors such as the complement factor H (CFH) Y402H polymorphism, smoking, and other plausible covariates.
This research forms part of, and contributed greatly to, the WA Macular Degeneration Study (WAMDS); a cross-sectional clinic-based case series of 1013 AMD cases comprising 675 choroidal neovascularisation (CNV) patients, 71 geographic atrophy patients, and 267 “early” (Age-Related Eye Disease Study [AREDS] grades 1-3) patients. Case-control analyses of subphenotypes utilised either or both of the geographic atrophy and early AMD subsets as „controls.. All participants were existing patients of the Lions Eye Institute Elsie Gadd Eye Clinic in Nedlands, Western Australia.
DNA samples were genotyped for C2/CFB using a haplotype-tagging set of 19 single nucleotide polymorphisms (SNPs) to capture 78% of the common variation in these genes. Additionally, the DNA samples were also genotyped for the CFH Y402H variant. AMD severity was graded according to the AREDS scale by ophthalmologists upon review of fundus photographs. Smoking and other relevant environmental/medical histories were collected via a comprehensive questionnaire. The multivariate associations of tagging SNPs and AMD phenotypes were tested.
Significant associations between C2/CFB genetic variants and AMD subphenotypes were observed. The rs7746553 (P = 0.04), rs3020644 (P = 0.008) and rs4151657 (P = 0.02) variants were associated with neovascular AMD; rs7746553 was also associated with legal blindness (P = 0.04). The rs2072633 (P = 0.002), rs1048709 (P = 0.005) and rs537160 (P = 0.002) variants were associated with neovascular lesion composition. Models were adjusted for appropriate covariates and CFH Y402H, and all P values were adjusted for multiple testing.
These results support the hypothesis, suggesting that C2/CFB genetic variants are associated with altered/compromised functioning of the alternative complement pathway and with a concomitant increased risk of developing more severe AMD independent of the CFH Y402H variant. Additionally, in establishing this study, I and my collaborators have created a comprehensive and useful resource for current and future AMD research.
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BHAGAT, ALI ASGAR SALEEM. "DESIGN AND CHARACTERIZATION OF PLANAR LOW REYNOLDS NUMBER MICROFLUIDIC MIXERS FOR LAB-ON-A-CHIP APPLICATIONS." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1154956875.
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Venosa, Robert Donato. ""Freedom Will Win—If Free Men Act!": Liberal Internationalism in an Illiberal Age, 1936-1956." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1588271691660565.
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Fernandes, João Pedro Lourenço. "Corporate governance and the impact on German companies' performance." Master's thesis, Instituto Superior de Economia e Gestão, 2014. http://hdl.handle.net/10400.5/7671.
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Mestrado em FinançasQual a relação existente entre corporate governance e a performance? Este estudo ajuda a esclarecer esta questão e deslindar este tema dentro do mercado Alemão. Os resultados obtidos a partir de uma análise empírica com uma amostra de 61 empresas Alemãs cotadas em bolsa, durante o espaço temporal de 2005-2008 proporcionam suporte para uma característica específica na Alemanha, a representação dos empregados na Administração da empresa, relacionando-a com uma boa performance. Este estudo obtém evidência de um impacto positivo na performance, ao nível medidas de operacionalidade, de CEOs com mais idade e da componente de remuneração variável dos directores de supervisão. A concentração acionista apresenta um efeito positivo nas medidas de performance de mercado. As empresas detidas pelo Estado apresentam, em média, melhor performance do que as restantes.
What is the relationship between corporate governance and performance? This study helps to understand this question and examine this issue on the German market. Results drawn from an analysis of a sample of 61 German quoted companies over the period 2005?2008 provide support for the Germany specific characteristic of the employee representation on the board of directors and its positive relation with performance. The research provides evidence of positive impact on performance of older CEOs and Supervisory Board variable remuneration, on the level of operating performance measures. Shareholder concentration has a positive effect on the market based performance measure studied. Evidence regarding the type of owner, shows companies held by the State have better performance on average.
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Zaidan, Nada Mousa O. "The role of Gata3 in blood stem cell emergence." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274544.
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The first definitive haematopoietic stem cells (HSCs) produced during embryonic development are generated from a specialised subset of endothelial cells known as haemogenic endothelium. Recently, it was reported that Gata3 plays a dual role in the development of sympathetic nervous system and haematopoietic system. In fact, Gata3 has proven to be crucial for the production of HSCs through regulation of catecholamine production from the co-developing sympathetic nervous system. Also, it was recently shown that Gata3 is expressed in the haemogenic endothelium and haematopoietic progenitor cells. Here, I will specifically examine the role of Gata3 in the production of HSCs; if it is expressed and plays a role in the precursors from which HSCs arise. Using a Gata3-GFP reporter mouse line, we found that Gata3 is expressed in various cell types in the HSCs microenvironment, including mesenchymal cells, endothelial cells, haematopoietic cells and sympathetic nervous system, and this expression was stage dependant. In the endothelial cells, we have found that the haemogenic endothelium activity is enriched in Gata3 expressing cells. Within the haematopoietic cells, we have found that Gata3 marks a specific stage along the developmental pathway towards the generation of definitive haematopoietic stem cells, and that Gata3 expressing haematopoietic cells are enriched for the most immature and stem cell like progenitors. Moreover, Gata3 will be specifically knocked out in haemogenic endothelial cells to determine whether it plays an essential role in the production of HSCs from the endothelium using the Vec-Cre system. We found that Gata3 within the haemogenic endothelium plays a major role in haematopoietic progenitors formation, and possibly haematopoietic stem cell formation. Finally, we used molecular assay (RNA seq) to identify the role of Gata3 in the haematopoietic stem cell microenvironment and found that Gata3 plays a major role in the development and differentiation of various cells and systems, and implicated Gata3 as cell cycle regulator. In summary, we found that Gata3 expressing cells is enriched for haemogenic endothelium, crucial for the haematopoietic progenitors formation, plays and important role in endothelial to haematopoietic transition, and plays a key developmental role in both haematopoietic stem cell and its microenvironment.
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Oliveira, Jos? Evandro Gerv?sio de. "Assimetrias e semelhan?as da cria??o de equinos no Sul do Brasil (RS) e na Argentina: aspectos produtivos, sanit?rios e comerciais." Universidade Federal Rural do Rio de Janeiro, 2012. https://tede.ufrrj.br/jspui/handle/jspui/2424.
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2012 - Jos? Evandro Gerv?sio de Oliveira.pdf: 1339113 bytes, checksum: 157cc8e574872feafeb6d9df50fd7792 (MD5)Made available in DSpace on 2018-09-11T13:48:17Z (GMT). No. of bitstreams: 1 2012 - Jos? Evandro Gerv?sio de Oliveira.pdf: 1339113 bytes, checksum: 157cc8e574872feafeb6d9df50fd7792 (MD5) Previous issue date: 2012-08-14
Businesses that involve the creation and use of the horse occupy a prominent position in developed countries and in many those developing countries, like Brazil and Argentina. However, little is known about the configuration of the Horse Agribusiness, particularly their contribution in generating income and jobs. Highlighting the need for studies aimed at the development of this activity and related economic sectors, since the breeding of horse in Brazil is approximately 5.8 million and 2.5 million heads in Argentina. There is a growing interest in scientific research in the production of horses. Agricultural activity in Brazil and Argentina, specifically the production of horses and their derivatives, has great relevance for the economy of both countries. Within this context, there is a chance that the knowledge of this chain is the main factor in the increase of production and generation of employment and income. Thus, this study aims to verify the asymmetries and similarities in the production of horses in southern Brazil (RS) and Argentina, analyzing the productive, health and trade aspects. This is a descriptive study, the multiple case study, which uses empirical research to investigate a contemporary phenomenon. The methodology used during this descriptive study comprised collection, tabulation and analysis of primary and secondary data, through field work and library research. The sample consisted of horses producers in Rio Grande do Sul, Brazil and in Argentina, the intentional type non-probabilistic. The collected data were tabulated in a spreadsheet Excell Version 2010 and for the descriptive analyzes it was used the Statistical Package for Social Science (SPSS Inc. Chicago, Illinois, USA), version 15.0. To complement the statistical analyzes were performed nonparametric analyzes on the observed frequencies. The observed frequencies were evaluated in 2x2 contingency tables. Relative frequencies were compared using the chi-square (?2) test at 5% probability using the InStat statistical package. As a result, it was observed that there is a similarity in various aspects in the production and trade, whereas in the health aspects are asymmetry in certain respects. It was concluded that at the complex agribusiness horse there are several activities that resemble and other distinguished. Based on this study, regional policies could be implemented in order to develop best practices observed by optimizing the horse production in both countries.
Os neg?cios que envolvem a cria??o e utiliza??o do cavalo ocupam uma posi??o de destaque nos pa?ses desenvolvidos e em muitos daqueles em desenvolvimento, como o Brasil e a Argentina. No entanto, pouco se conhece sobre a configura??o do Agroneg?cio do Cavalo, particularmente, a sua contribui??o na gera??o de renda e de postos de trabalho. Destacandose a necessidade de estudos que visem o desenvolvimento desta atividade e dos segmentos econ?micos relacionados, visto que o plantel de equino brasileiro ? de, aproximadamente, 5,8 milh?es de cabe?as e 2,5 milh?es na Argentina. H? um crescente interesse em pesquisas cient?ficas no complexo de cavalos. A atividade agropecu?ria no Brasil e na Argentina, especificamente, a produ??o de equinos e seus derivados, possuem grande relev?ncia para economia de ambos os pa?ses. Dentro desse contexto, existe a hip?tese de que o conhecimento dessa cadeia ? o principal fator na eleva??o da produ??o e gera??o de emprego e renda. Sendo assim, esse trabalho tem por objetivo verificar as assimetrias e semelhan?as na cria??o de equinos no sul do Brasil (RS) e na Argentina, analisando os aspectos produtivos, sanit?rios e comerciais. Trata-se de um estudo descritivo, do tipo estudo de caso m?ltiplo, que utiliza uma investiga??o emp?rica para averiguar um fen?meno contempor?neo. A metodologia utilizada no decorrer desse estudo descritivo compreendeu coleta, tabula??o e an?lise de dados prim?rios e secund?rios, atrav?s de trabalhos de campo e pesquisas bibliogr?ficas. A amostra foi constitu?da por produtores de equinos do Rio Grande do Sul, Brasil e da Argentina, do tipo intencional n?o probabil?stica. Os dados coletados foram tabulados em planilha eletr?nica Excell Vers?o 2010 e para as an?lises descritivas utilizou-se o Statistical Package for Social Science (SPSS Inc. Chicago, Illinois, EUA), vers?o 15.0. A fim de complementar as an?lises estat?sticas, foram efetuadas as an?lises n?o param?tricas sobre as frequ?ncias observadas. As frequ?ncias observadas foram avaliadas em tabelas de conting?ncias 2x2. As frequ?ncias relativas foram comparadas por meio do teste de Qui-quadrado (?2) a 5% de probabilidade, utilizando-se o pacote estat?stico InStat. Como resultado, observou-se que existe uma semelhan?a em v?rios aspectos na produ??o e no comercial, enquanto que no sanit?rio h? uma assimetria em alguns aspectos. Concluiu-se que no complexo do agroneg?cio equino existem diversas atividades que se assemelham e outras que se distinguem. Com base neste estudo, pol?ticas regionais poderiam ser implantadas a fim de se desenvolver as melhores pr?ticas observadas, otimizando a cria??o de equinos em ambas as localidades
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LUPO, GIUSEPPE FRANCESCO DAMIANO. "RUOLO POTENZIALE DEL MICROBIOMA NELLA SINDROME DA AFFATICAMENTO CRONICO/ ENCEFALOMIELITE MIALGICA (CFS/ME)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2020. http://hdl.handle.net/10280/72840.
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La Sindrome da Affaticamento Cronico/Encefalomielite Mialgica (CFS/ME), è una grave malattia multisistemica caratterizzata da anomalie immunologiche e disfunzioni del metabolismo energetico.
Recenti evidenze suggeriscono l’esistenza di una forte correlazione tra disbiosi e condizione patologica. La presente ricerca ha analizzato la composizione del microbiota intestinale ed orale in pazienti con CFS/ME rispetto a controlli sani e ha determinato se eventuali differenze osservate potrebbero essere utili in futuro per l'identificazione di biomarcatori diagnostici.
La composizione batterica fecale e salivare dei pazienti con CFS/ME è stata studiata mediante sequenziamento Illumina degli ampliconi del gene 16S rRNA.
Il microbiota fecale dei pazienti con CFS/ME ha mostrato una significativa riduzione di Lachnospiraceae, in particolare di Anaerostipes, rispetto ai gruppi di soggetti senza CFS/ME e un incremento di Phascolarctobacterium faecium e unclassified Ruminococcus. Bacteroides vulgatus, unclassified Bacteroides, Bacteroides uniformis e unclassified Barnesiella sono risultati significativamente più abbondanti nei pazienti con CFS/ME.
Il microbiota orale dei pazienti con CFS/ME ha mostrato un aumento significativo di Rothia dentocariosa. Il profilo metabolico fecale di un sottogruppo di pazienti con CFS/ME ha mostrato un aumento complessivo di SCFA e di derivati dell'indolo rispetto ai gruppi non CFS/ME, suggerendo un aumento dei processi di fermentazione.
I nostri risultati supportano l'ipotesi autoimmune per la CFS/ME e se saranno confermati da studi più ampi, le differenze rilevate nei profili microbici dei pazienti CFS/ME potrebbero essere utilizzate come markers per una diagnosi più accurata e per lo sviluppo di strategie terapeutiche specifiche.The Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), is a severe multisystemic disease characterized by immunological abnormalities and dysfunction of energy metabolism. Recent evidence suggest that there is a strong correlation between dysbiosis and pathological condition. The present research investigated the composition of the intestinal and oral microbiota in CFS/ME patients in comparison to healthy controls and determined whether any observed differences could be useful for the identification of diagnostic biomarkers. The fecal and salivary bacterial composition in CFS/ME patients was investigated by Illumina sequencing of 16S rRNA gene amplicons. The fecal microbiota of CFS/ME patients showed a significant reduction of Lachnospiraceae, particularly Anaerostipes, compared to the non-CFS/ME groups, and an increase of Phascolarctobacterium faecium and unclassified Ruminococcus. Bacteroides vulgatus, unclassified Bacteroides, Bacteroides uniformis and unclassified Barnesiella resulted significantly more abundant in CFS/ME patients. The oral microbiota of CFS/ME patients showed a significant increase of Rothia dentocariosa. The fecal metabolic profile of a subgroup of CFS/ME patients revealed an overall increase of SCFAs and indole derivatives compared to the non-CFS/ME groups, suggesting an increase in the fermentation processes. Our results support the autoimmune hypothesis for CFS/ME condition and if confirmed by larger studies, the differences detected in the microbial profiles of CFS/ME patients may be used as markers for a more accurate diagnosis and for the development of specific therapeutic strategies.
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Urban, Ondřej. "Větrání tělocvičny." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-372264.
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The master thesis deals with flow modeling in the CFD program. By means of which the opti-mal version of the air distribution diffuser in the sports hall will be selected. The first variant will bring fresh air through textile diffusers. The second variant will bring fresh air through flooded large circular diffusers. The tested parameter of the indoor environment will be the flow velocity and the age of the air. The better-performing version will be processed as an implementation documentation.
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Oliveira, Cinthia Soares de. "Muitas hist?rias, uma imagem: a percep??o s?cio-ambiental de alunos residentes da Escola Agr?cola de Jundia?" Universidade Federal do Rio Grande do Norte, 2008. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12301.
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Previous issue date: 2008-01-03Tendo como base os conceitos de espa?o, lugar, ambiente e imagem, sob as vertentes da Arquitetura e Urbanismo, Geografia e Psicologia Ambiental, esta pesquisa teve como objetivo averiguar a percep??o de estudantes da Escola Agr?cola de Jundia? (EAJ UFRN) a fim de identificar aspectos das interrela??es pessoa-ambiente que diferenciam tal escola de outras institui??es. A coleta de dados utilizou multim?todos e investigou um grupo de alunos residentes na Escola que cursavam o ensino m?dio e t?cnico em agropecu?ria em 2006, analisando seus discursos, comportamentos e atitudes de modo a identificar os principais elementos da imagem s?cio-ambiental da EAJ. Os resultados apontaram locais, pr?ticas sociais e s?mbolos representativos da institui??o, indicando espa?os (constru?dos e naturais) adequados/inadequados ?s necessidades/expectativas dos estudantes incluindo a amplia??o da interdisciplinaridade no conjunto de suas atividades. Al?m disso, a fim de incrementar a an?lise s?cio-ambiental em institui??es que promovem experi?ncias exitosas, recomenda-se que os aspectos cotidiano e tempo sejam mais profundamente investigados em estudos futuros na ?rea
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Jůza, Štěpán. "Proudění vzduchu v uzavřeném prostoru budovy." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265727.
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Masters degree thesis with name “Air flow in closed space” in teoretical part describes air flow. Defined here basic types of flow including the flow in a closed space and the methods for the description of the air flow. The practical part deals with project eva-luation distribution of air conditioning system using CFD model. Next solves a second variant of air distribution and compare the changes that have occurred. The end of the practical part approaching the possibility of using CFD model for creating the quality environment maps and the possibility to create variants of calculating with changing levels of the supply air.
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Pereira, M?nica Cox de Britto. "M?nica Cox de. Media??o de conflitos agr?rios e ambientais: um estudo sobre o Vale do S?o Jo?o no estado do Rio de Janeiro." Universidade Federal Rural do Rio de Janeiro, 2006. https://tede.ufrrj.br/jspui/handle/tede/679.
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Previous issue date: 2006-12-01Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
The research dealt with conflicts that occurred in S?o Jo?o River Valley on public lands disappropriated by INCRA to Biological Reserve of Po?o das Antas. We tried to understand them bringing into focus land conflicts, occupations and camps in the surrounding of Reserve at 1990. The thesis aims to show how, after sanitation work at 1980, some areas were invaded by farmers as well as rural workers required agrarian reform in those public lands. Biological Reserve began to dispute adjoining areas in order to enlargement and moved judicial actions against rural settlements. Along those conflicts, an environmental conception that considers man action as an external factor and nature as untouchable earned force of law and conflicted with land work right claimed by means of collective occupation. The thesis intends to show either the limits of State dialogue with workers organizations or conflicts resolutions between State agencies and at public politics conduction to rural settlements and to Biological Reserve. We tried to show that neither environmental question nor agrarian question can be understood isolated, they may be inter-related.
A pesquisa enfoca os conflitos que surgiram no Vale do Rio S?o Jo?o fluminense, em terras p?blicas desapropriadas pelo INCRA para cria??o da Reserva Biol?gica Po?o das Antas. Procura-se entend?-los a partir dos conflitos por terra e das ocupa??es e acampamentos no entorno da Reserva nos anos 1990. A tese procura mostrar como, ap?s obras de saneamento na d?cada de 1980, algumas ?reas foram griladas por fazendeiros, ao mesmo tempo em que trabalhadores rurais demandaram a reforma agr?ria nessas terras que eram p?blicas. A Reserva Biol?gica passou tamb?m a disputar ?reas cont?guas a seus limites originais para sua amplia??o e moveu a??es judiciais contra assentamentos no seu entorno. Ao longo desses conflitos, revelou-se, com for?a de lei, uma concep??o ambiental que v? a a??o do homem como fator externo ao ambiente e a natureza como intocada, passando a se antagonizar com o direito ao trabalho na terra demandado por meio de ocupa??o coletiva. A tese procura mostrar os limites existentes quer no di?logo do Estado com as organiza??es porta-vozes dos trabalhadores, quer na resolu??o dos conflitos entre as inst?ncias estatais e na condu??o das pol?ticas p?blicas para os assentamentos rurais e para a Reserva Biol?gica. Procura-se mostrar que nem a quest?o ambiental nem a quest?o agr?ria podem ser entendidas isoladamente e que elas necessitam ser inter-relacionadas.
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Billi, Alex. "Meccanismi di produzione dell'energia in astrofisica." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19480/.
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Ci sono vari meccanismi di produzione di energia in astrofisica; questo elaborato si concentrerà principalmente su due di essi. Nel capitolo 1 viene trattata l'energia prodotta dalle reazioni termonucleari nei nuclei stellari. Verranno trattati vari tipi di reazioni: principalmente le catene di bruciamento di idrogeno ed elio, con accenni alle reazioni di pre sequenza e quelle successive alla 3α. Nel capitolo 2 invece verrà trattato un meccanismo più "esotico": la produzione di energia che deriva dall'accrescimento di materia da parte dei buchi neri supermassicci (Super Massive Black Hole, SMBH). In questo
capitolo è presente anche una sezione in cui viene discusso l'esempio astrofisico di questo processo: i nuclei galattici attivi (Active Galactic Nuclei, AGN).
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Santos, Deusa Maria dos. "O Benef?cio de Presta??o Continuada BCP: as condi??es de vida dos usu?rios no Munic?pio de Macau/RN." Universidade Federal do Rio Grande do Norte, 2005. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17937.
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Previous issue date: 2005-10-15Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
This rescearch comprises a study of the life condictions of the users of the Continuous Installment Allowance in the city of Macau, RN. This benefit has been predicted by the Federal 1988 Constitution and regulated by the Social Assistance Organic Law (LOAS), but it has been carried out only since january 1996. It consists of an amount of half a minimum salary given to old-age and handicapped peoplewhose families mathch the per capita income criterion of less than 0,25 minimum salary. It is a least-income policy relud by the principle of the smallest elegibility. The study focused on aged or handicapped people who were receiving the BPC from 1996 to 2004. Through a quatitative analysis, the life reality of these users has been critically examined. In order to achieve this, it has been necessary to trace their social and economical profile. The research revealed the precarious life conditions of the aged and handicapeed people after they were given the BPC, as well as their interpretation of this politcal directive, and also the need for revision of the eligibility criteria so that a public policy of integral service to the basic needs of the social being can be accomplished
A pesquisa em quest?o compreende um estudo sobre as condi??es de vida dos usu?rios do Benef?cio de Presta??o Continuada no Munic?pio de Macau/RN. O BPC foi previsto na Constitui??o Federal de 1988 e regulamentado pela Lei Org?nica da Assist?ncia Social LOAS. Mas, s? teve sua concess?o a partir de janeiro de 1996. Este benef?cio consiste no repasse de um sal?rio m?nimo vigente ?s pessoas idosas e portadoras de defici?ncia, cujas fam?lias se enquadram no crit?rio de renda per capita inferior a ? do sal?rio m?nimo. Trata-se de uma pol?tica de renda m?nima que se rege pelo princ?pio da menor elegibilidade. O espa?o temporal compreendido abrangeu os idosos e portadores de defici?ncia que recebem o BPC entre o per?odo de 1996 a 2004. Atrav?s do estudo quanti-qualitativo, buscou-se apreender e analisar criticamente a realidade da vida desses usu?rios. Para tanto, fez-se necess?rio realizar o perfil dos benefici?rios, bem como sua caracteriza??o s?cio-econ?mica. Os resultados revelam as prec?rias condi??es de vida dos idosos e portadores de defici?ncia ap?s a concess?o do BPC, e apresentam a interpreta??o que os mesmos fazem desta pol?tica;Assim identifica-se a prem?ncia de serem revistos os crit?rios de elegibilidade dos benefici?rios, objetivando uma pol?tica p?blica de atendimento integral ?s necessidades b?sicas do ser social. Unitermos: Benef?cio de Presta??o Continuada, assist?ncia social, necessidades humanas, idosos e portadores de defici?ncia
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Tien-MingCheng and 鄭天銘. "CEO AGE AND TAX AVOIDANCE." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/sue63x.
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Zhan, Ya-Fan, and 詹雅帆. "The Factors That Influence the Age of Newly Appointed CEO?" Thesis, 2018. http://ndltd.ncl.edu.tw/handle/jz4rjz.
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碩士國立臺北商業大學
財務金融研究所
106
CEO is different from other management. The decisions they make have the influence of major decisions about the company and will influence the future direction of the company. Therefore, when a company hires a manager, the manager characteristics will be an important consideration. In this study, the listed company in Taiwan between 1999 and 2013 CEO turnover as samples to explore the factors affecting the age of newly appointed CEO and take the CEO characteristics, company investment decisions and financing decisions, and other factors as variables.The empirical results show that companies will change from CEO to different positions. When the transfer position is the chairman of the board, the main influencing factors are whether the company is a family business, financial leverage, capital expenditure, research and development and growth opportunities;. When the transfer position is general manager, the main influencing factors are whether the former CEO are voluntary resignation, manager gender and debt ratio
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Birgi, Elif Nazli. "AML/CFT regulations of EU in the age of virtual currency." Master's thesis, 2018. http://hdl.handle.net/1822/60949.
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Dissertação de mestrado em European and Transglobal Business LawGlobal consideration on money laundering has its origins in narco-trafficking of 1980s which raised public awareness and took international regulatory body’s attention. Throughout time, due to the socio-economic and political context, legislations on money laundering were transformed in order to introduce an efficient response to new issues. As a need in the aftermath of 9/11, counter-financing of terrorism (CFT) was included in the scope of anti-money laundering (AML) legislations, due to the intertwined nature of these two criminal matters. A new challenge to the AML/CFT legislations was introduced by the technological developments and the emergence of virtual currency. Appearing as an alternative, fast, easy and cheap non-cash payment method, its relation with criminal activities, widespread usage and unregulated operations raised concerns. When traditional approaches to the fight against money laundering and financing of terrorism were circumvented by pseudo-anonymous and decentralized nature of new transaction methods, existing legislations were forced to be transformed once more. European Union, taking its powers for regulating criminal matters from the Treaty of the Functioning of European Union (TFEU), proposed an amendment to the 4th AML, with the purpose of reducing anonymity of virtual currency. Not being accepted yet, its ability to produce an adequate respond to challenges, due to the special nature of virtual currency, is questionable. This thesis analyse European Union’s current Anti-Money Laundering legislation and its responsiveness to the characteristics of virtual currency that are attributable to the risks, with particular attention to crypto-currency, through a critical perspective. It aimed to raise awareness of the subject matter and contribute to the future of AML/CFT reuglations of the EU.
A preocupação internacional com o branqueamento de capitais está ligada ao narcotráfico da década de oitenta. Ao longo do tempo e devido ao contexto sócio económico e político, a legislação relacionada com o branqueamento de capitais foi sendo adaptada, permitindo introduzir uma resposta mais eficiente aos novos desafios. Isto foi particularmente visível na sequência dos ataques de 11 de setembro, momento a partir do qual a prevenção do financiamento do terrorismo passou a estar incluída no domínio do branqueamento de capitais, atendendo à ligação próxima entre estes dois fenómenos. Um novo desafio à legislação sobre branqueamento de capitais surgiu como desenvolvimento tecnológico, nomeadamente com o aparecimento de cripto-moedas. As moedas virtuais surgiram como uma alternativa rápida, fácil e pouco dispendiosa, para realizar pagamentos. Porém, a sua associação a atividades criminosas, uso generalizado e ausência de regulamentação própria conduziram a fortes preocupações por parte das entidades reguladoras. As abordagens tradicionais de combate à lavagem de dinheiro e financiamento do terrorismo tornaram-se obsoletas perante a natureza descentralizada e pseudoanónima destes novos métodos de transações, demandando uma reforma célere da legislação existente. A União Europeia, utilizando o Tratado sobre o Funcionamento da União Europeia como forma de fundamentar os seus poderes, propôs uma alteração à diretiva 4.ª AML, com o objetivo de reduzir o anonimato das cripto-moedas. Não tendo sido ainda aprovada, a capacidade desta alteração produzir a resposta adequada aos desafios apresentados pela natureza especial das moedas virtuais é, no mínimo, questionável. O trabalho aqui apresentado analisa a atual legislação europeia contra o branqueamento de capitais e a sua capacidade de responder às características das moedas virtuais, às quais se atribui um elevado risco. Tem também como objetivo salientar questões relativas a esta temática e despertar maior interesse, assim como contribuir para o futuro da regulamentação AML/CFT da União Europeia.
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I-TIENLEE and 李沂恬. "The influence of CEO age on financial decisions: Evidence from firms in Taiwan." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/8b8ke2.
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葉伯璋. "Hydrodynamic Simulations of Proton Exchange Membrane Fuel Cell with CFD-ACE+ code." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/43277947826055822429.
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碩士國立清華大學
工程與系統科學系
93
Abstract The report summarizes the results of the numerical simulations of proton exchange membrane fuel cell (PEMFC) by computational fluid dynamic (CFD) software. The code employed is CFD-ACE+ developed by ESI-CFDRC Company. The purpose of the study is to assess the capabilities of CFD-ACE+ code in the simulations of PEMFC. The phenomena involved in the water and heat management of PEMFC are very complicated. The phenomena involved include the flow of multi-component and multi-phase fluid in an open channel and through porous media, the electrochemical reactions at catalyst layers, the evaporation and condensation of water, conduction and convection heat transfer. A three-dimension single cell PEMFC model is built and the input values of the physical and chemical parameters of PEMFC are collected from the literatures surveyed. The measured polarization curves of a PEMFC can be reproduced by the present simulations. The PEMFC simulation results of CFD-ACE+ are examined and discussed in detail to check the consistency of the simulated results. Sensitivity studies are performed. The parameters considered in the sensitivity studies are the direction of flow (co-flow and counter flow), the thermal conductivities of membrane-electrode assembly (MEA), the coefficient of the proton in the JANNAF method which calculates the enthalpy of the mix gases, the thermal boundary condition of fuel cell outer surface (constant temperature and convective). The result of the simulations demonstrated that CFD-ACE+ has the capabilities to simulate the hydrodynamic phenomena of PEMFC. However, the code does not provide enough output about liquid water flow in the channel and its distribution in the fuel cell. Key words: PEMFC, PEFC, CFDs, heat and water analytic.
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Abootorabi, Seyedalireza. "Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow." Thesis, 2020. http://hdl.handle.net/1805/23571.
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Indiana University-Purdue University Indianapolis (IUPUI)The thesis includes two application studies of computational fluid dynamics. The first is new and efficient drug delivery to the posterior part of the eye, a growing health necessity worldwide. Current treatment of eye diseases, such as age-related macular degeneration (AMD), relies on repeated intravitreal injections of drug-containing solutions. Such a drug delivery has significant cant drawbacks, including short drug life, vital medical service, and high medical costs. In this study, we explore a new approach of controlled drug delivery by introducing unique porous implants. Computational modeling contains physiological and anatomical traits. We simulate the IgG1 Fab drug delivery to the posterior eye to evaluate the effectiveness of the porous implants to control the drug delivery. The computational model was validated by established computation results from independent studies and experimental data. Overall, the results indicate that therapeutic drug levels in the posterior eye are sustained for eight weeks, similar to those performed with intravitreal injection of the same drug. We evaluate the effects of the porous implant on the time evaluation of the drug concentrations in the sclera, choroid, and retina layers of the eye. Subsequent simulations were carried out with varying porosity values of a porous episcleral implant. Our computational results reveal that the time evolution of drug concentration is distinctively correlated to drug source location and pore size. The response of this porous implant for controlled drug delivery applications was examined. A correlation between porosity and fluid properties for the porous implants was revealed in this study. The second application lays in the computational modeling of the oscillating
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Börncke, Florian. "Funktionelle Charakterisierung der mit altersabhängiger Makuladegeneration (AMD) assoziierten Komplementfaktor-H-Variante Y402H." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0006-B2D4-9.
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Murphy, Caitlin. "The Visual Impairment/Cognitive Impairment Co-morbidity : Examining the Genotype-Structure-Function Relationship." Thèse, 2017. http://hdl.handle.net/1866/19986.
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