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Journal articles on the topic 'Cervical lymphadenopathy'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Marvin, Kastley, Gregory Capra, and David P. Mullin. "Cervical Lymphadenopathy." JAMA Otolaryngology–Head & Neck Surgery 141, no. 11 (November 1, 2015): 1023. http://dx.doi.org/10.1001/jamaoto.2015.2358.

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2

Glumbíková, Veronika, and Richard Salzman. "Cervical lymphadenopathy." Medicína pro praxi 19, no. 4 (September 29, 2022): 259–63. http://dx.doi.org/10.36290/med.2022.040.

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3

Weinstock, Michael S., Neha A. Patel, and Lee P. Smith. "Pediatric Cervical Lymphadenopathy." Pediatrics in Review 39, no. 9 (August 31, 2018): 433–43. http://dx.doi.org/10.1542/pir.2017-0249.

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4

Al Awfi, Mahmood Masud, Yahya Al Badaai, and Ibrahim Al Haddabi. "Unilateral Cervical Lymphadenopathy." Oman Medical Journal 35, no. 2 (March 15, 2020): e121-e121. http://dx.doi.org/10.5001/omj.2020.39.

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5

Kim, Chang Duck. "Right Cervical Lymphadenopathy." Journal of the Korean Medical Association 42, no. 3 (1999): 283. http://dx.doi.org/10.5124/jkma.1999.42.3.283.

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6

Choi, Jin Hyuk. "Multiple Cervical Lymphadenopathy." Journal of the Korean Medical Association 44, no. 6 (2001): 661. http://dx.doi.org/10.5124/jkma.2001.44.6.661.

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7

Rosenberg, Tara L., and Abby R. Nolder. "Pediatric Cervical Lymphadenopathy." Otolaryngologic Clinics of North America 47, no. 5 (October 2014): 721–31. http://dx.doi.org/10.1016/j.otc.2014.06.012.

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8

LEUNG, A., and W. ROBSON. "Childhood cervical lymphadenopathy." Journal of Pediatric Health Care 18, no. 1 (January 2004): 3–7. http://dx.doi.org/10.1016/s0891-5245(03)00212-8.

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9

Gilbert, Latoni Kaysha, and Janavikulam Thiruchelvam. "Cervical silicone lymphadenopathy." British Journal of Oral and Maxillofacial Surgery 54, no. 6 (July 2016): e52-e54. http://dx.doi.org/10.1016/j.bjoms.2016.01.011.

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10

Pasticci, Maria. "Acute Cervical Lymphadenopathy." Emerging Infectious Diseases 2, no. 3 (September 1996): 241. http://dx.doi.org/10.3201/eid0203.960316.

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11

Sato, J., H. Tsubota, and T. Himi. "Syphilitic cervical lymphadenopathy." European Archives of Oto-Rhino-Laryngology 260, no. 5 (December 3, 2002): 283–85. http://dx.doi.org/10.1007/s00405-002-0559-6.

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12

Khan, R., S. H. Harris, A. K. Verma, and A. Syed. "Cervical lymphadenopathy: scrofula revisited." Journal of Laryngology & Otology 123, no. 7 (October 10, 2008): 764–67. http://dx.doi.org/10.1017/s0022215108003745.

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AbstractBackground:The commonest form of extrapulmonary tuberculosis is tubercular cervical lymphadenitis, or scrofula.Methods and results:A total of 1827 patients with cervical lymphadenopathy who presented to various out-patients clinics of our institution were studied over a three-year period. Eight hundred and ninety-three (48.87 per cent) of these patients had lesions of tubercular origin. The most common observation was unilateral, matted adenopathy in female patients aged between 11 and 20 years and without constitutional symptoms of tuberculosis. Posterior triangle nodes were affected in 43.8 per cent of cases, followed by upper deep cervical nodes in 33.9 per cent. Fine needle aspiration cytology constituted the main diagnostic tool, with a positive yield in 90 per cent of patients. Polymerase chain reaction analysis was performed in 126 patients, with a sensitivity of 63 per cent. Only 18 per cent of patients had associated pulmonary tuberculosis, the rest having isolated involvement of cervical nodes. Medical treatment with anti-tubercular drugs for a period of six months formed the mainstay of treatment and cure. Surgical management was reserved for selected refractory patients.Conclusion:Tubercular cervical lymphadenitis can readily be diagnosed by fine needle aspiration cytology, a simple and cost-effective test. The disease can be cured completely by a short course of anti-tubercular chemotherapy, without surgical intervention.

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13

Peters, Timothy R., and Kathryn M. Edwards. "Cervical Lymphadenopathy and Adenitis." Pediatrics in Review 21, no. 12 (December 2000): 399–405. http://dx.doi.org/10.1542/pir.21-12-399.

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Peters, Timothy R., and Kathryn M. Edwards. "Cervical Lymphadenopathy and Adenitis." Pediatrics In Review 21, no. 12 (December 1, 2000): 399–405. http://dx.doi.org/10.1542/pir.21.12.399.

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15

Kaji, Arjun Vikram, Tamara Mohuchy, and Joel D. Swartz. "Imaging of cervical lymphadenopathy." Seminars in Ultrasound, CT and MRI 18, no. 3 (June 1997): 220–49. http://dx.doi.org/10.1016/s0887-2171(97)90021-4.

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16

Mukhia, Rupesh, Sushama Bhatta, Ganesh Simkhada, Abishek Thapa, and Rupashia Mukhia. "Clinico-pathological evaluation of cervical lymphadenopathy." Journal of Society of Surgeons of Nepal 22, no. 2 (December 31, 2019): 23–36. http://dx.doi.org/10.3126/jssn.v22i2.28740.

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Introduction: Cervical lymph nodes are peripheral lymphoid organs distributed in the neck. The term lymphadenopathy refers to nodes that are palpable and abnormal in size, consistency or numbers. Diagnosis of cervical lymphadenopathy can vary from neoplasm to various kinds of infection. Accurate diagnosis of the cause of lymphadenopathy can sometimes be challenging and can lead to delay in diagnosis causing delayed treatment and subsequent health issues. Methods: A prospective observational study was carried out on 78 patients of cervical lymphadenopathy who presented in the surgical outpatient department of KIST Medical College. Detailed history, physical examination and necessary investigations including fine needle aspiration cytology were done in all patients Results: Most patients were between 21 to 40 years of age. The commonest cause for cervical lymphadenopathy was reactive lymphadenitis (53.84%) followed by Tuberculosis (34.61%). Secondary metastasis was seen in 7 patients (8.97%). In tubercular lymphadenitis, the anterior triangle group was the most commonly involved group of cervical lymph nodes (74 %), followed by the posterior triangle and supraclavicular equally (11.11%). Conclusions: Reactive Lymphadenopathy is the commonest cause of cervical lymphadenopathy. However, variable diagnosis can be possible from non-neoplastic to neoplastic condition.

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David, Sandeep Kumar, Bonny A. Joseph, Easwarapillai B. K., and R. R. Varma. "Proportion of malignancy in cervical lymphadenopathy." International Surgery Journal 4, no. 10 (September 27, 2017): 3378. http://dx.doi.org/10.18203/2349-2902.isj20174499.

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Background: Cervical lymphadenopathy is a commonly encountered presenting complaint in out-patient departments. There are many reasons for cervical lymphadenopathy in a range spanning from benign through infective to malignant pathology. This study aims to find out the proportion of malignancy in such patients.Methods: 100 patients with cervical lymphadenopathy who fulfilled the criteria were included in the study from January 2015 to June 2016. Each patient underwent clinical examination and investigations including ESR, total count, fine needle aspiration cytology and biopsy.Results: Out of the 100 cases examined, 19 (19%) had malignancy. Among them, 6 (6%) had primary malignancy and 13 (13%) had secondary malignancy. 25 (25%) had tuberculous lymphadenopathy and 46 (46%) had reactive hyperplasia.Conclusions: There is significant incidence of malignancy in patients with cervical lymphadenopathy. The most common was metastatic lymph node from a primary malignancy. It is important to keep this in mind while evaluating a case of cervical lymphadenopathy.

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Deosthali, Ankita, Katherine Donches, Michael DelVecchio, and Stephen Aronoff. "Etiologies of Pediatric Cervical Lymphadenopathy: A Systematic Review of 2687 Subjects." Global Pediatric Health 6 (January 2019): 2333794X1986544. http://dx.doi.org/10.1177/2333794x19865440.

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Background. Cervical lymphadenopathy in children is common and its etiologies diverse. No systematic review of the differential diagnosis of pediatric cervical lymphadenopathy has been conducted. Objective. To determine the prevalence rate of specific etiologies of pediatric cervical lymphadenopathy. Data Sources. EMBASE, PubMed, and SCOPUS were searched electronically. Bibliographies of select studies were reviewed as well. Study Selection. (1) Any clinical trial, observational study, or cross-sectional case series with 10 or more subjects that included delineation of etiologies and/or associated conditions with lymphadenopathy; (2) subjects aged 0 to 21 years with enlarged lymphoid tissue on body; (3) lymphadenopathy was confirmed by clinical evaluation; and (4) no specific diagnoses were excluded. Data Extraction. Year and location of publication, definition of lymphadenopathy, percentage of lymphadenopathy that was cervical, total number of subjects, gender distribution of subjects, age range of patients, and specific etiologies. Results. Of the 1790 studies, 7 studies that were combined resulted in 2687 subjects that were selected. Nonspecific benign etiology was the most common diagnosis occurring at a rate of 67.8%. Epstein-Barr virus was the next most prevalent (8.86%), followed by malignancy (4.69%) and granulomatous disease (4.06%). The most common malignancy etiology was non-Hodgkin’s lymphoma (46.0%), and the most common granulomatous disease was tuberculosis (73.4%). Conclusions. This systematic review and meta-analysis provides a rate-based differential diagnosis of pediatric cervical lymphadenopathy. Although the most common causes of pediatric cervical lymphadenopathy are nonspecific, the etiologies are diverse. Rates and credible intervals are provided to enable a probability-based diagnostic approach to palpable cervical lymphadenopathy in this age group.

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Bhatta, Sushama, Samir Singh, and Sangita Regmi Chalise. "Diagnostic Value of Fine Needle Aspiration Cytology in the Assessment of Cervical Lymphadenopathy." Med Phoenix 3, no. 1 (August 15, 2018): 36–40. http://dx.doi.org/10.3126/medphoenix.v3i1.20760.

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Background: Cervical lymphadenopathy is one of the most frequent clinical manifestations of patients attending outpatient department. The etiology of cervical lymphadenopathy varies from inflammatory condition to malignant lesion. Fine needle aspiration cytology (FNAC) is a safe, easy and quick diagnostic technique. It has become the first line of investigation in the evaluation of lymphadenopathy. The objective of this study was to evaluate the spectrum of lesions in cervical lymphadenopathy and role of FNAC in the diagnosis of cervical lymphadenopathy.Methods: This study was conducted over a period of two years (May 2015 to May 2017). 206 patients with cervical lymphadenopathy were included in the study.Results: Most of the cases were non-neoplastic (91.74 %) whereas (8.26 %) cases were neoplastic. The most common cause of non-neoplastic lymphadenopathy was reactive lymphadenitis. Histocytological correlation was done in 32 cases. The diagnostic accuracy of FNAC for metastatic carcinoma and reactive lymphadenitis was 100% and 93.75% respectively.Conclusions: FNAC is a safe, cost effective and reliable procedure to diagnose the causes of cervical lymphadenopathy.Med Phoenix. Vol. 3, Issue. 1, 2018, Page: 36-40

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20

Harikrishnan, Volga, Sulochana Sonti, and Chitra Srinivasan. "Diagnostic Evaluation of Cervical Lymphadenopathy in FNAC Samples." Annals of Pathology and Laboratory Medicine 6, no. 4 (April 29, 2019): A180–184. http://dx.doi.org/10.21276/apalm.1935.

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21

Rahman, Md Atiqur, Md Mamun Ali Biswas, Syeda Tasfia Siddika, and Abdul Mannan Sikder. "Histomorphological Pattern of Cervical Lymphadenopathy." Journal of Enam Medical College 3, no. 1 (February 17, 2013): 13–17. http://dx.doi.org/10.3329/jemc.v3i1.13837.

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Background: Enlarged palpable cervical lymph nodes as a primary presenting sign are very common and may be due to inflammatory lesions and tumors. Correlation between clinical findings and laboratory data is essential in arriving at a diagnosis. In patients presenting with cervical lymphadenopathy, excision biopsy provides material to establish an early diagnosis. We designed this study in our population for histological evaluation of cervical lymph node biopsies that might be important in the management of these patients. Objective: Histopathological evaluation of different diseases involving the cervical lymph nodes in relation to age and sex of the study population. Materials and Methods: It was a cross sectional study conducted in the department of Pathology, Enam Medical College & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. A total of 107 patients were evaluated for specific cause of cervical lymphadenopathy in relation to age and sex. Lymph node biopsies of all patients of both sexes and all age groups were included in the study. Results: Among the 107 subjects 58 (54.2%) were males and 49 (45.8%) were females with a male to female ratio of 1.2:1. The age of the patients ranged from 2 to 85 years with a mean age of 32.68 ± 18.01 years. Of the 107 lymph node biopsies, 34 cases (31.8%) were reactive lymphadenitis, 41 cases (38.3%) were tuberculosis, 2 cases (1.9%) were non-caseous granuloma, 6 cases (5.6%) were Hodgkin lymphoma, 8 cases (7.5%) were non-Hodgkin lymphoma, 12 cases (11.2%) were metastatic neoplasm and 4 cases (3.7%) were other specific lesions. Conclusion: The commonest cause of cervical lymphadenopathy was tuberculosis, followed by reactive lymphadenitis, lymphoma and metastatic neoplasm. DOI: http://dx.doi.org/10.3329/jemc.v3i1.13837 J Enam Med Col 2013; 3(1): 13-17

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22

Guruswamy, Chetas H., K. Ananth Prabhu, and H. R. Basavaraj. "Cervical lymphadenopathy: a clinicopathological study." International Surgery Journal 8, no. 5 (April 28, 2021): 1428. http://dx.doi.org/10.18203/2349-2902.isj20211446.

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Background: Aim of the study was to evaluate the clinical presentation and histopathological findings in patients presenting with cervical lymphadenopathy.Methods: Patients presenting to the outpatient units and admitted in the wards of departments of general surgery and onco-surgery, Yenepoya medical college hospital, Mangalore from December 2017 to December 2019 were included in the study.Results: From December 2017 to December 2019, 130 patients had presented with cervical lymphadenopathy to our hospital. Cervical lymphadenopathy was most common in the age group of 50-60 years and in males. The most common histopathological diagnosis was found to be secondaries in the neck. Multiple lymph node level involvement was more common.Conclusions: To conclude, cervical lymphadenopathy is seen frequently. In this study conducted in a tertiary centre 130 cases were reported in a span of two years of the study period. Further analysis of age and gender distribution, clinical and histopathological analysis suggested that in majority, age group was found to be above 50 years, with male preponderance. Commonest cause was secondaries in the neck (28.5%) followed by tubercular lymphadenitis (24.6%).

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23

Naik, Sudhir, BL Yatish Kumar, S. Ravishankara, T. Shashikumar, R. Navya, and P. Sathya. "Kikuchi's Disease: A Rare Clinical Entity of Cervical Lymphadenopathy with Review of Literature." An International Journal of Otorhinolaryngology Clinics 8, no. 3 (2016): 101–5. http://dx.doi.org/10.5005/jp-journals-10003-1241.

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ABSTRACT Background and objectives Kikuchi disease is an uncommon, idiopathic, generally self-limited cause of lymphadenitis. The disease runs a self-limiting course usually resolving in 6 to 8 months of occurrence, with the usual clinical manifestations being cervical lymphadenopathy, with or without systemic manifestations. Materials and methods A retrospective study was done in three cases of Kikuchi disease reported over 2 years. All three females had cervical lymphadenopathy not responding to empirical treatment. All had excision of the lymph nodes with immunohistochemistry, which suggested the necrotizing lymphadenopathy. Other similar diagnoses, like systemic lupus erythematosus, non-Hodgkin's lymphoma, Kawasaki, tuberculous, metastatic lymphadenopathy, were excluded. Conclusion The rare possibility of cervical lymphadenopathy being Kikuchi's disease should be thought if empirical therapy fails. So, a meticulous effort by the pathologist and surgeon helps in diagnosing the self-limiting, little understood disease of Kikuchi in young patients with cervical lymphadenopathy and fever. How to cite this article Naik SM, Kumar BLY, Ravishankara S, Shashikumar T, Navya R, Sathya P. Kikuchi's Disease: A Rare Clinical Entity of Cervical Lymphadenopathy with Review of Literature. Int J Otorhinolaryngol Clin 2016;8(3):101-105.

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Patel, Kiran. "A clinical study of tuberculous cervical lymphadenopathy: surgeon’s perspectives." International Surgery Journal 6, no. 2 (January 28, 2019): 581. http://dx.doi.org/10.18203/2349-2902.isj20190407.

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Background: Cervical lymphadenopathy is common in this country. There are many causes of cervical lymphadenopathy like, malignancies, infections, autoimmune disorders, iatrogenic, and other miscellaneous conditions. There are more chances of wrong clinical diagnosis in case of lymphadenopathy than any other diseases. The present study was planned with the objective to study the clinical presentation of tuberculous cervical lymphadenopathy.Methods: A prospective, cross-sectional study was undertaken with inclusion of all cases of cervical lymphadenopathy attending the department of general surgery. The patients with cervical lymphadenopathy irrespective of age, sex, caste, religion, socio-economic status, duration and severity of illness were included in this study. The patients with primary malignancy, patients with clinical features of suspected malignancy like obvious growth or ulcer in head and neck region and pregnant women were excluded from the study.Results: Total 130 patients presented with cervical lymphadenopathy during the study duration. Infective etiology was the commonest (55, 42.31%) cause for the cervical lymphadenopathy followed by TB (50, 38.46%). The commonest age group affected by tuberculous cervical lymphadenopathy (TCL) was 20-35 years. The females (29, 58.00%) were more affected with TCL as compared to males (21, 42.00%). A majority of the patients (45, 90.00%) had unilateral TCL. Commonly involved lymph node group was level V (26, 52.00%). Other than excision biopsy (12 patients), no other type of surgery was needed in patients.Conclusions: Though, anti-tuberculous chemotherapy is the mainstay of treatment for TCL, surgical treatment is more useful in selected cases. In this regard, early diagnosis and treatment are critical in lowering the overall prevalence. Therefore, it is important that surgeons are aware of tuberculosis in the head and neck region.

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25

Motiwala, Mohammed Ali, Deepak Dalmia, and Sanjaya Kumar Behara. "Cervical lymphadenopathy: a clinicopathological study." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 2 (March 25, 2017): 210. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20171176.

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<p class="abstract">Cervical lymphadenopathy is one of the commonest presentations of underlying pathology of the head and neck region which has large number of differential diagnosis like neoplasms, infections (specific and non-specific), immune deficiency disorders and rare disorders like Inflammation. Pseudotumour (plasma cell granuloma) and Kikuchi-Fujimoto disease.</p><p class="abstract"><strong>Methods:</strong> The present study is a prospective study conducted in our institution Dr B.A.M. Central Railway Hospital, Mumbai. Our study included 115 patients with cervical lymphadenopathy presenting with swelling of more than 1.5 cm size in longest diameter. All the patients included in our study are more than 12 years of age, in whom the lymph node did not regress after adequate antibiotic therapy in acute cases (i.e. Conservative management for at least 2 week), and all the chronic cervical lymphadenopathy patients. </p><p class="abstract"><strong>Results:</strong> Tuberculosis was found to be the most common cause of cervical Lymphadenopathy in 54.78% cases followed by reactive lymphadenitis in 22.61% cases, chronic nonspecific lymphadenitis in 12.17% cases and metastatic lymphadenopathy in 7.83% cases. Other causes were unknown primary in 1.74% cases and non-Hodgkin’s lymphoma in 0.87% cases. Sensitivity and specificity of FNAC was 79.36% and 100% respectively.</p><p><strong>Conclusions:</strong> Tuberculosis, reactive lymphadenitis and malignancy are the most important cause of cervical Lymphadenopathy. They present in different age groups with different clinical feature. Fine Needle Aspiration Cytology (FNAC) is extremely sensitive and highly specific investigation for early diagnosis</p>

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26

Moura, Ana Cecilia C. Almeida de, and Fátima C. Mendes de Matos. "COVID-19 and cervical lymphadenopathy." Archives of Head and Neck Surgery 51 (2022): e20220003. http://dx.doi.org/10.4322/ahns.2022.0003.

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27

King, Ann D., Anil T. Ahuja, and Constantine Metreweli. "MRI of Tuberculous Cervical Lymphadenopathy." Journal of Computer Assisted Tomography 23, no. 2 (March 1999): 244–47. http://dx.doi.org/10.1097/00004728-199903000-00013.

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28

Yazıcı, Zahide Mine. "Approach to pediatric cervical lymphadenopathy." Praxis of Otorhinolaryngology 3, no. 3 (November 23, 2015): 117–21. http://dx.doi.org/10.5606/kbbu.2015.44127.

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29

R, Pradeep Kulal, Sharvan R. Shanbhag, Kumar Dontamsetty V V M S, Madhu B S, and Ramu B K. "CLINICOPATHOLOGICAL STUDY OF CERVICAL LYMPHADENOPATHY." Journal of Evolution of Medical and Dental Sciences 4, no. 54 (July 6, 2015): 9437–48. http://dx.doi.org/10.14260/jemds/2015/1367.

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30

Al Busaidi, Ibrahim, Danyal Saeed, and Isaac I. Bogoch. "Cervical lymphadenopathy due tolymphogranuloma venereuminfection." Sexually Transmitted Infections 93, no. 8 (November 24, 2017): 589. http://dx.doi.org/10.1136/sextrans-2016-052839.

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31

Bede, Salwan Yousif Hanna, Auday M. Al-Anee, and Hassanien A. Aljumaily. "Surgical Biopsy in Cervical Lymphadenopathy." Journal of Baghdad College of Dentistry 28, no. 4 (December 2016): 111–14. http://dx.doi.org/10.12816/0033220.

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32

Turk, A. J. "Hoarseness, cough and cervical lymphadenopathy." European Respiratory Journal 26, no. 1 (July 1, 2005): 174–77. http://dx.doi.org/10.1183/09031936.05.00137004.

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Biller, Jason A., Michael C. Scheuller, and David W. Eisele. "Coccidioidomycosis Causing Massive Cervical Lymphadenopathy." Laryngoscope 114, no. 11 (November 2004): 1892–94. http://dx.doi.org/10.1097/01.mlg.0000147916.35992.e7.

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34

Daley, AJ. "Non-tuberculous mycobacterial cervical lymphadenopathy." Journal of Paediatrics and Child Health 37, no. 1 (February 11, 2001): 78–80. http://dx.doi.org/10.1046/j.1440-1754.2001.00627.x.

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TAKATO, Tsuyoshi, and Hideto SAIJO. "The diagnosis of cervical lymphadenopathy." Japanese Journal of Oral & Maxillofacial Surgery 54, no. 8 (2008): 468–73. http://dx.doi.org/10.5794/jjoms.54.468.

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36

Connor, S. E. J., and J. F. C. Olliff. "Imaging of malignant cervical lymphadenopathy." Dentomaxillofacial Radiology 29, no. 3 (2000): 133–43. http://dx.doi.org/10.1038/sj.dmfr.4600521.

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37

Kumar Singh Bhadouriya, Sunil, Kansal H M, Rohit Saxena, Vivek Kumar Pathak, and Sanjeev Kumar Awasthi. "CLINICOPATHOLOGICAL STUDY OF CERVICAL LYMPHADENOPATHY." Journal of Evolution of Medical and Dental Sciences 5, no. 66 (August 18, 2016): 4730–34. http://dx.doi.org/10.14260/jemds/2016/1078.

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Karthik, S. Venkatesh. "Emerging challenges in cervical lymphadenopathy." Hospital Medicine 64, no. 6 (June 2003): 376. http://dx.doi.org/10.12968/hosp.2003.64.6.376a.

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39

Kubba, H. "A child with cervical lymphadenopathy." Clinical Otolaryngology 31, no. 5 (October 2006): 433–34. http://dx.doi.org/10.1111/j.1749-4486.2006.01308.x.

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40

Hoyt, David J., and Samuel R. Fisher. "Kikuchi's Disease Causing Cervical Lymphadenopathy." Otolaryngology–Head and Neck Surgery 102, no. 6 (June 1990): 755–58. http://dx.doi.org/10.1177/019459989010200621.

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41

Joy, Priya, G. Gayathri, and V. Gangadharan. "Cervical lymphadenopathies: a diagnostic crisis." International Journal of Advances in Medicine 4, no. 5 (September 22, 2017): 1490. http://dx.doi.org/10.18203/2349-3933.ijam20174310.

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Cervical lymphadenopathy refers to lymphadenopathy of the cervical lymph nodes. The causes are varied, and may be inflammatory, degenerative, infective or neoplastic. The first case presented here is of a 29-year old male presented with h/o recurrent progressive right sided painless swelling in the infraparotid region with cervical lymphadenopathy for past one year. Swelling was 6×6cm, nontender, firm mass. Cervical lymph nodes were palpable. He had raised eosinophil counts and elevated serum IgE levels. Biopsy showed abundant eosinophilic infiltration with microabscess suggestive of Kimura’s disease. Second case reported here is of a 17-year old female patient presented with fever for 3 weeks with cervical lymphadenopathy. The lymph node was 3×2cm, tender and firm. Routine blood investigations showed anemia. Biopsy showed lymph nodes composed of sheets of macrophages with crescent shaped nuclei with areas of necrosis and karyhorrhexis suggestive of Kikuchi’s disease. Kimura’s disease is a relatively uncommon chronic inflammatory benign condition mostly affecting the lymph nodes, subcutaneous tissue and salivary glands of head and neck region. It is seen in males in their second decade of lives. Peripheral eosinophilia, regional lymphadenopathy and elevated serum IgE levels are characteristics of Kimura’s disease. Kikuchi-Fujimoto disease is a benign, idiopathic and self-limited disease. Affects young females between 20-35 years of age. Usually there will be localized painful lymphadenopathy, fever and leukopenia. Kikuchi disease runs a benign course and resolves in several weeks to months. The two cases are presented to make clinicians aware of Kimura’s disease and Kikuchi’s disease as a differential diagnosis of cervical lymphadenopathy and to avoid the diagnostic dilemma both clinically and histopathologically.

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Shreepaili, Ashok, and Sushil Dhakal. "Malignant Cervical Lymphadenopathy among Fine Needle Aspiration Cytology in a Tertiary Care Center in Far Western Nepal: A Descriptive Cross-sectional Study." Med Phoenix 6, no. 2 (February 16, 2022): 2–6. http://dx.doi.org/10.3126/medphoenix.v6i2.42692.

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Introduction Metastatic cervical lymphadenopathy is a diagnostic and therapeutic challenge. The utility of Fine Needle Aspiration Cytology is well established in the diagnosis of metastatic lymph nodes, new-onset, or recurrence. This study aims to find the prevalence of metastatic cervical lymphadenopathy among fine needle aspiration cytology in a tertiary care center in far western Nepal. Materials and Methods This is a descriptive cross-sectional study carried out in Seti Provincial Hospital and Maya Metro Hospital, Dhangadhi, Kailali, Nepal between July 2018 to December 2019. Total 534 cervical lymph node aspirations were performed during this period out of which 48 cases were cytologically proven as malignant lymph nodes. Clinical charts and cytology reports of patients with malignant lymph nodes were reviewed. Results Out of 534 cervical lymph node aspirations performed during the study period, the number of malignant lymph nodes was 48 (8.99%). Among malignant lymph nodes (n=48), primary hematolymphoid malignancy was 14 (29.17%) and metastatic cervical lymphadenopathy was 34 (70.83%). Metastatic squamous cell carcinoma was the most common etiology of metastatic cervical lymphadenopathy followed by nasopharyngeal carcinoma and papillary carcinoma of the thyroid. Conclusion Fine needle aspiration cytology has been proved to be a valuable tool in the initial evaluation of metastatic cervical lymphadenopathy in resource-limited settings. Metastatic squamous cell carcinoma is the most common diagnosis in metastatic cervical lymphadenopathy.

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Vivekanandarajah, A., B. Krishnarasa, M. Hurford, and S. Gupta. "Kikuchi's Disease: A Rare Cause of Fever and Lymphadenopathy." Clinical Medicine Insights: Pathology 5 (January 2012): CPath.S8685. http://dx.doi.org/10.4137/cpath.s8685.

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Kikuchi's disease is a benign condition that occurs in women. A young woman presented to the hospital with fevers and cervical lymphadenopathy. Infectious work-up was negative except for streptococcus pharyngitis. Imaging studies revealed the presence of diffuse cervical and axillary lymphadenopathy. The fevers persisted and she underwent excisional cervical lymph node biopsy that revealed histiocytic necrotizing lymphadenitis corresponding to a benign diagnosis of Kikuchi's disease. Three months later, the patient was afebrile and there was complete resolution of the cervical lymphadenopathy.

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Virdee, Jaspreet, Roya Hazara, and Michael Amin. "A pain in the neck: cervical lymphadenopathy in metastatic disease." Dental Update 48, no. 11 (December 2, 2021): 942–45. http://dx.doi.org/10.12968/denu.2021.48.11.942.

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Cervical lymphadenopathy can serve as a silent progressive indicator of systemic pathology and metastatic disease. Incidental or asymptomatic cervical lymphadenopathy can present a clinical dilemma when deciding on appropriate referral pathways and in specialist investigations. Metastasis to the head and neck may be more easily identified than locating the primary tumour site, which often requires a multitude of investigations to achieve an accurate diagnosis. As highlighted in this case report, primary care dentists play a central role in identification of patients with cervical lymphadenopathy who may require urgent specialist input in the context of subclavicular disease. CPD/Clinical Relevance: This article highlights the clinical assessment of cervical lymphadenopathy and the investigatory tools used in secondary care to facilitate diagnosis.

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Schweitzer, Vanessa G., and Gregg D. Bobier. "Sinus Histiocytosis with Massive Cervical Lymphadenopathy." Annals of Otology, Rhinology & Laryngology 95, no. 4 (July 1986): 331–35. http://dx.doi.org/10.1177/000348948609500403.

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Sinus histiocytosis with massive cervical lymphadenopathy (SHML) was originally described in 1969 as a benign clinicopathologic entity characterized by massive bilateral cervical lymphadenopathy, fever, leukocytosis, elevated ESR, and hypergammaglobulinemia, usually occurring within the first two decades of life. We present an illustrated case of an elderly patient with polyclonal hypergammaglobulinemia and a 2-year history of multilobulated cervical and submandibular lymphadenopathy. The etiology and pathogenesis of SHML are not known. Diagnosis requires lymph node biopsy to exclude other causes of cervical lymphadenopathy such as malignant lymphoma, malignant histiocytosis, metastatic carcinoma, and tuberculous lymphadenitis. Histologic examination shows marked dilatation of subcapsular and medullary lymph node sinuses containing large, foamy or vacuolated histiocytes. Although no curative treatment is known, corticosteroids, radiation therapy, vinblastine and oral cyclophosphamide, and surgery have been used to palliate constitutional symptoms and mechanical obstruction from massive lymphadenopathy. Since one third of SHML patients have evidence of disease for 5 years, and a mortality rate of 7% exists with benign histologic disease, all patients with SHML should be carefully screened for evidence of immunodeficiencies that may precipitate a fatal outcome.

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Janagam, Chandralekha, and Bhagyalakshmi Atla. "Role of FNAC in the diagnosis of cervical lymphadenopathy." International Journal of Research in Medical Sciences 5, no. 12 (November 25, 2017): 5237. http://dx.doi.org/10.18203/2320-6012.ijrms20175383.

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Background: Cervical lymphadenopathy is one of the commonest presentations in inflammatory and neoplastic disorders. Fine Needle Aspiration Cytology (FNAC) is simple, quick, inexpensive and minimally invasive OPD technique used for establishing the etiology of cervical lymphadenopathy. In this study we describe cytomorphological patterns of cervical lymph nodes and its utility in establishing diagnosis. Objectives of present study were to assess the distribution of various cytomorphological patterns of cervical lymphadenopathy and to assess the age specific distribution of various cytomorphological patterns of cervical lymphadenopathy.Methods: This study was carried out in the Department of Pathology, Andhra Medical College on 200 cases of cervical lymphadenopathy over a period of three months from August - October 2017. FNAC diagnosis was correlated with relevant clinical findings and investigations.Results: Total 200 cases were studied. Of these, 170 (85%) were inflammatory and 30 (15%) were neoplastic. Reactive non-specific lymphadenitis was the most common disease found in 95 (47.5%) patients followed by tuberculous lymphadenitis in 60 patients (30%) and granulomatous lymphadenitis in 15 patients (7.5%). Among neoplastic lesions, metastatic tumours were reported in 26 patients (13%) and Lymphoproliferative disorder/Lymphoma was reported in 4 patients (2%). Highest incidence of cervical lymphadenopathy was found in patients of 10-39 years age group, among which most of the cases were non-specific lymphadenitis followed by tuberculous lymphadenitis. Amongst the neoplastic lesions, most of the cases were in the age group of 40-79 years.Conclusions: FNAC is simple, safe, reliable procedure for diagnosis of cervical lymphadenopathy.

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Aparup Dhua, Pranab Mandal, Priya Ranjan Chattopadhyay, and Santu Kumar Samanta. "A study on cervical lymphadenopathy in a rural based teaching hospital in India." Asian Journal of Medical Sciences 13, no. 10 (October 1, 2022): 133–37. http://dx.doi.org/10.3126/ajms.v13i10.45766.

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Background: Presence of cervical lymphadenopathy may indicate serious systemic disease process. Proper evaluation of cervical lymphadenopathy is of extreme clinical importance. Aims and Objective: The study objective was to evaluate clinical and demographic profile of cervical lymphadenopathy, to find the etiology, and to study the role of fine-needle aspiration cytology (FNAC) in it’s etiological diagnosis. Materials and Methods: Prospective observational study was carried out in a rural based teaching hospital in India for 1 year. One hundred and twenty-one patients of more than 12 years of age from both genders were included in the study. Detailed history, clinical, blood examination, radiological, microbiological evaluation, and FNAC from lymph node were done for all patients. Excision biopsy was done for selective cases. Results: It was a male predominant study with male: female ratio of 1.12:1 and mean age of the patient was 34.54 years. Cervical lymphadenopathy was mostly unilateral (77.69%) and it was more common in the right side (43.80%). Tuberculosis (TB) (36.37%) was the most common cause of cervical lymphadenopathy in our study followed by reactive hyperplasia of lymph node (23.14%) and metastatic deposit (19%). Among metastatic deposit, 9 (39.13%) had squamous cell carcinoma, 5 (21.74%) had adenocarcinoma, and 1 (4.35%) had small cell carcinoma. Conclusion: TB is the most common cause of cervical lymphadenopathy followed by reactive hyperplasia and metastatic secondary deposit. FNAC is a simple inexpensive relatively painless rapid and reliable method for diagnosis which can be considered as a frontline investigation and can guide requirement for further investigation in the management of cervical lymphadenopathy.

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Alkumasi, Hussein Ali, Mohammed Reda Al Ghadhban, and Faris Talib Mohammed. "Common sites and causes of chronic cervical lymphadenopathy among a sample of Iraqi patients." International Surgery Journal 5, no. 3 (February 26, 2018): 892. http://dx.doi.org/10.18203/2349-2902.isj20180798.

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Background: Chronic cervical lymphadenopathy may result from a variety of different underlying diseases. It could be a sign of inflammation, metastatic tumor or lymphoma.Methods: This is a prospective study of 60 patients with cervical lymphadenopathy who attended Al Karama Teaching Hospital for the period (1/12/2008 to 1/2/2010). Data includes their demographic information, clinical presentation, investigations and histopathological results.Results: Twenty six patients were males (43.3%) and 34 were females (56.7%). The male to female ratio was 1:1.3. Age distribution had shown that the highest incidence occurred in those between (11-20) years old (15 patients, 25%), followed by those between (1-10) years old. The mean age was 31.2±21.5 SD. The most common cause of cervical lymphadenopathy was reactive hyperplasia (23 patients, 38.3%) followed by Tuberculous lymphadenopathy (15patients, 25%). Lymphomas (13 patients, 21.7%) and metastatic deposits (7 patients, 11.7%).Conclusions: The most common cause of cervical lymphadenopathy was reactive hyperplasia followed by tuberculous lymphadenopathy. Tuberculous lymphadenopathy continues to be a major health problem, and this may be explained by situation in this country in the last few decades that affected the socio-economic, health care and the living standard of population.

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Marwat, Arshad Ali, Farmanullah Burki, Aftab Ahmad, Amir Amanullah, and Kamran Iqbal. "FREQUENCY AND DISTRIBUTION OF DIFFERENT TYPES OF CERVICAL LYMPHADENOPATHY IN PATIENTS IN D.I.KHAN DISTRICT, PAKISTAN." Gomal Journal of Medical Sciences 16, no. 1 (March 31, 2018): 12–14. http://dx.doi.org/10.46903/gjms/16.01.1510.

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Background: Cervical lymphadenopathy is a common medical problem. The objective of the study was to determine the frequency and distribution of different types of cervical lymphadenopathy in patients in D.I.Khan, KP, Pakistan. Material & Methods: This cross sectional study was conducted at Department of ENT, Gomal Medical College, Dera Ismail Khan from April 2013 to March 2016. Sample size was 80, selected through consecutive sampling technique. Patients having enlarged lymph nodes of either sex and of any age of at least 2 months duration were included. Patients having generalized lymphadenopathy were excluded from the study. Gender and age groups were the demographic variables. The research variables were types of cervical lymphadenopathy (tuberculous lymphadenopathy/ reactive hyperplasia/ metastatic carcinoma/ lymphpoma) and side of the neck involved (right/ left). All variables being categorical, the frequencies and percentages were calculated. descriptive statistical analysis was done using SPSS version 10. Results: Out of 80 patients, 42 were males and 38 females. Majority of the patients were in the first decade. Chronic granulomatous diseases especially the tuberculous cervical lymphadenopathy was the most frequent histological findings in 31 patients. Lymphoma was noted in 21, reactive hyperplasia in 18 and metastatic malignancy in 10 cases. Lymph nodes involvement on the right side was more common 36 than on the left side 32. Conclusion: Unilateral tuberculous cervical lymphadenopathy was most common found especially in young males.

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Adeyemo, Adebolajo A. "Metastatic cervical lymphadenopathy masquerading as extrapulmonary tuberculosis." Bangladesh Journal of Otorhinolaryngology 18, no. 2 (November 24, 2012): 234–37. http://dx.doi.org/10.3329/bjo.v18i2.12030.

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Introduction: Cervical lymphadenopathy can be due to various pathologies especially in the young. A high index of suspicion is required in the management of cervical lymphadenopathy to prevent misdiagnosis and wrong treatment.Case report: Here present the diagnostic challenge in the case of a young lady with nasopharyngeal carcinoma who initially presented solely with cervical lymphadenopathy. Previous fine needle aspiration cytology had suggested tuberculosis (TB) and she was commenced on anti-TB drugs. However failure of improvement and worsening symptoms led to another review in ENT clinic. A subsequent nasopharyngeal biopsy confirmed nasopharyngeal carcinoma. She subsequently improved after commencement of appropriate treatment.Conclusion: In regions with a high prevalence rate of tuberculosis, care must be taken to exclude malignancy in patients with cervical lymphadenopathy even when cytology suggests a granulomatous infection. DOI: http://dx.doi.org/10.3329/bjo.v18i2.12030 Bangladesh J Otorhinolaryngol 2012; 18(2): 234-237

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