Academic literature on the topic 'Cerebrospiral fluid'

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Journal articles on the topic "Cerebrospiral fluid"

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Carrette, Odile, Pierre R. Burkhard, Severine Hughes, Denis F. Hochstrasser, and Jean-Charles Sanchez. "Truncated cystatin C in cerebrospiral fluid: Technical artefact or biological process?" PROTEOMICS 5, no. 12 (August 2005): 3060–65. http://dx.doi.org/10.1002/pmic.200402039.

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Carrette, Odile, Pierre R. Burkhard, Severine Hughes, Denis F. Hochstrasser, and Jean-Charles Sanchez. "Truncated cystatin C in cerebrospiral fluid: Technical artefact or biological process? (vol. 5, Issue 12, pp. 3060-3065)." PROTEOMICS 5, no. 14 (September 2005): 3822. http://dx.doi.org/10.1002/pmic.200590062.

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Kesavan, T. M. Ananda. "Cerebrospinal Fluid Examination in Meningitis: Diagnostic Dilemmas." Indian Journal of Trauma and Emergency Pediatrics 10, no. 2 (2018): 53–56. http://dx.doi.org/10.21088/ijtep.2348.9987.10218.4.

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Than Aye, Than, Aye Aye Sann, and Hpone Pyae Tun. "Recurrent bacterial meningitis with cerebrospinal fluid rhinorrhea." International Journal of Case Reports and Images 13, no. 2 (November 28, 2022): 210–14. http://dx.doi.org/10.5348/101362z01ta2022cr.

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Introduction: Recurrent bacterial meningitis is a rare clinical phenomenon, but a telltale sign of a mysterious foe. It is an occurrence of two or more episodes of bacterial meningitis by different organisms, or with the same organism and the episodes separated by an interval of at least three weeks. Case Report: We present a case of a 29-year-old gentleman who presented with acute pyogenic meningitis due to Streptococcus pneumoniae. This is the second episode of confirmed bacterial meningitis in two years with another episode of meningitis ten years ago, which was treated as tuberculous. History of rhinorrhea was elicited on direct questioning and cerebrospinal fluid leak through cribriform plate was confirmed on magnetic resonance imaging. The current episode of meningitis was successfully treated with intravenous high dose cephalosporin and short course dexamethasone. The patient was referred to a neurosurgeon for closure of cerebrospinal fluid leak. Conclusion: This case highlights the importance of a thorough clinical history and awareness of a seemingly unimportant symptom which can be an important diagnostic clue.
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Galan, A., A. Seisdedos-Benzal, BE Carletti, S. Quiros, EM Martin, D. Menor, and MM Granados. "Cisternal versus lumbar cerebrospinal fluid lactate concentration in healthy dogs." Veterinární Medicína 65, No. 7 (July 10, 2020): 297–300. http://dx.doi.org/10.17221/136/2019-vetmed.

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The analysis of cerebrospinal fluid biomarkers provides a wide range of information about the neurological health of a patient. Lactate is a metabolic precursor necessary for brain gluconeogenesis. When oxidative impairment or mitochondrial damage is present, lactate alteration occurs. The rostro-caudal dynamics of cerebrospinal biomarkers along the craniospinal axis in humans and horses was demonstrated in other studies. To the authors’ knowledge, no clinical study has, so far, investigated the cerebrospinal fluid lactate concentration in dogs in association with the puncture site. The purpose of this study was to compare the cerebellomedullary cistern and lumbar cistern cerebrospinal fluid lactate concentrations in healthy dogs. Cerebellomedullary and lumbar cerebrospinal fluids were collected for the cell count, total protein determination and lactate analysis from ten healthy Beagle dogs. The results revealed a significantly increased lumbar cerebrospinal fluid lactate concentration when compared with the cerebellomedullary cistern level. The results included: the total nucleated cell count < 5 cells/µl, the red blood cell count < 500 cell/µl, the total proteins < 0.3 g/l, as well as the cerebellomedullary lactate values (1.44 ± 0.06 mM/l) and the lumbar cistern lactate values (1.58 ± 0.1 mM/l). The results of this study highlight useful data that help to understand the physiological lactate variations depending on the cerebrospinal fluid puncture site.
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Lauridsen, Karin Holst, Kristine Boisen Olsen, Eva Løbner Lund, Tomas O. Jensen, Thomas Ingemann Pedersen, Zitta Barrella Harboe, Valeria Antsupova, et al. "Neurological Complications in COVID-19 Patients: Can Analysis of Specific Antibodies and Viral RNA in Paired Cerebrospinal Fluid and Serum be Used for Accurate Diagnosis of SARS-CoV-2 Neuroinflammatory Disease? A Case Series." Clinical Pathology 15 (January 2022): 2632010X2211390. http://dx.doi.org/10.1177/2632010x221139096.

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Background: Neurological complications during and after SARS-CoV-2 infection have been frequently described. The detection of either SARS-CoV-2 RNA or specific antibodies against SARS-CoV-2 in cerebrospinal fluid in the context of concomitant neurological manifestations indicates neuroinfection. Methods and Results: This is a retrospective descriptive analysis of cerebrospinal fluids and serum samples from 2 hospitalized patients and autopsy findings from 2 patients who died at home. Samples were analysed by 3 independent enzyme-linked immunosorbent assays. Specific antibodies against SARS-CoV-2 were detected in cerebrospinal fluids and paired serum in all 4 cases. Levels of antibodies in cerebrospinal fluids were highest in samples from a deceased man with critical progression of COVID-19 and detectable SARS-CoV-2 viral RNA in cerebrospinal fluid, serum, 4 brain biopsies and 15 additional tissue samples, though immunohistochemical staining for SARS-CoV-2 in brain tissue did not detect the virus. Conclusion: Detection of SARS-CoV-2 antibodies in paired serum and cerebrospinal fluid may support the presence of SARS-CoV-2 neuroinflammatory disease in patients with COVID-19 and neurological manifestations.
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Bhaskar, Amit, Mohammad Shafat Imam Siddiqui, Kumar Bhaskar, and Smitha S. "Adenosine Deaminase Levels in Cerebrospinal Fluid in Different Etiology of Meningitis." Academia Journal of Medicine 2, no. 2 (July 24, 2019): 186–89. http://dx.doi.org/10.21276/ajm.2019.2.2.48.

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Krishnan, G. Sundhar, V. J. Vikram, and Shruthi Satish. "ENDOSCOPIC TRANSNASAL REPAIR OF CEREBROSPINAL FLUID RHINORRHEA - ANALYSIS OF 400 CASES." ORISSA JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY 10, no. II (December 31, 2016): 36–41. http://dx.doi.org/10.21176/ojolhns.2016.2.6.

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Peate, Ian. "Body fluids: components and disorders of cerebrospinal fluid." British Journal of Healthcare Assistants 2, no. 9 (September 2008): 434–36. http://dx.doi.org/10.12968/bjha.2008.2.9.31170.

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Kumari, Deepa, Shampa Anupurbha, Manish Gupta, Sarita Kumari, and Anup Singh. "Correlation of GeneXpert and cerebrospinal fluid culture in patients of tubercular meningitis." Asian Pacific Journal of Health Sciences 5, no. 2 (June 2018): 148–51. http://dx.doi.org/10.21276/apjhs.2018.5.2.28.

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Dissertations / Theses on the topic "Cerebrospiral fluid"

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Owler, Brian Kenneth. "Pathophysiology of normal pressure hydrocephalus." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/685.

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Normal pressure hydrocephalus (NPH), a CSF circulation disorder, is important as a reversible cause of gait and cognitive disturbance in an aging population. The inconsistent response to CSF shunting is usually attributed to difficulties in differential diagnosis or co-morbidity. Improving outcome depends on an increased understanding of the pathophysiology of NPH. Specifically, this thesis examines the contribution of, and inter-relationship between, the brain parenchyma and CSF circulation in the pathophysiology of NPH. Of the four core studies of the thesis, the first quantifies the characteristics of the CSF circulation and parenchyma in NPH using CSF infusion studies to measure the resistance to CSF absorption and brain compliance. The second study assesses cerebral blood flow (CBF) was using O15-labelled positron emission tomography (PET) with MR co-registration. By performing CSF infusion studies in the PET scanner, CBF at baseline CSF pressure and at a higher equilibrium pressure is measured. Regional changes and autoregulatory capacity are assessed. The final study examines the microstructural integrity of the parenchyma using MR diffusion tensor imaging. These studies confirm the importance of the inter-relationship of the brain parenchyma and CSF circulation. NPH symptomatology and its relationship to the observed regional CBF reductions in the basal ganglia and thalamus are discussed. Regional CBF reductions with increased CSF pressure and the implications for autoregulatory capacity in NPH are considered. The reduction in CBF when CSF was increased was most striking in the periventricular regions. In addition, periventricular structures demonstrated increased diffusivity and decreased anisotropy. The relationship between these changes and mechanisms such as transependymal CSF passage are reviewed. The findings of this thesis support a role of both the CSF circulation and the brain parenchyma in the pathophysiology of NPH. The results have implications for the approach to the management of patients with NPH.
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Owler, Brian Kenneth. "Pathophysiology of normal pressure hydrocephalus." University of Sydney. Surgery, 2004. http://hdl.handle.net/2123/685.

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Normal pressure hydrocephalus (NPH), a CSF circulation disorder, is important as a reversible cause of gait and cognitive disturbance in an aging population. The inconsistent response to CSF shunting is usually attributed to difficulties in differential diagnosis or co-morbidity. Improving outcome depends on an increased understanding of the pathophysiology of NPH. Specifically, this thesis examines the contribution of, and inter-relationship between, the brain parenchyma and CSF circulation in the pathophysiology of NPH. Of the four core studies of the thesis, the first quantifies the characteristics of the CSF circulation and parenchyma in NPH using CSF infusion studies to measure the resistance to CSF absorption and brain compliance. The second study assesses cerebral blood flow (CBF) was using O15-labelled positron emission tomography (PET) with MR co-registration. By performing CSF infusion studies in the PET scanner, CBF at baseline CSF pressure and at a higher equilibrium pressure is measured. Regional changes and autoregulatory capacity are assessed. The final study examines the microstructural integrity of the parenchyma using MR diffusion tensor imaging. These studies confirm the importance of the inter-relationship of the brain parenchyma and CSF circulation. NPH symptomatology and its relationship to the observed regional CBF reductions in the basal ganglia and thalamus are discussed. Regional CBF reductions with increased CSF pressure and the implications for autoregulatory capacity in NPH are considered. The reduction in CBF when CSF was increased was most striking in the periventricular regions. In addition, periventricular structures demonstrated increased diffusivity and decreased anisotropy. The relationship between these changes and mechanisms such as transependymal CSF passage are reviewed. The findings of this thesis support a role of both the CSF circulation and the brain parenchyma in the pathophysiology of NPH. The results have implications for the approach to the management of patients with NPH.
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Cardillo, Giulia. "Fluid Dynamic Modeling of Biological Fluids : From the Cerebrospinal Fluid to Blood Thrombosis." Thesis, Institut polytechnique de Paris, 2020. http://www.theses.fr/2020IPPAX110.

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Dans cette thèse, trois modèles mathématiques ont été proposés, avec l’objectif de modéliser autant d’aspects complexes de la biomédecine, dans lesquels la dynamique des fluides du système joue un rôle fondamental: i) les interactions fluide-structure entre la pulsatilité du liquide céphalo-rachidien et la moelle épinière (modélisation analytique); ii) dispersion efficace d’un médicament dans l’espace sous-arachnoïdien (modélisation numérique); et iii) la formation et l’évolution d’un thrombus au sein du système cardiovasculaire (modélisation numérique).Le liquide céphalorachidien est un fluide aqueux qui entoure le cerveau et la moelle épinière afin de les protéger. Une connaissance détaillée de la circulation du liquide céphalorachidien et de son interaction avec les tissus peut être importante dans l’étude de la pathogenèse de maladies neurologiques graves, telles que la syringomyélie, un trouble qui implique la formation de cavités remplies de liquide (seringues) dans la moelle épinière.Par ailleurs, dans certains cas, des analgésiques - ainsi que des médicaments pour le traitement de maladies graves telles que les tumeurs et les infections du liquide céphalorachidien - doivent être administrés directement dans le liquide céphalorachidien. L’importance de connaître et de décrire l’écoulement du liquide céphalorachidien, ses interactions avec les tissus environnants et les phénomènes de transport qui y sont liés devient claire. Dans ce contexte, nous avons proposé: un modèle capable de décrire les interactions du liquide céphalo-rachidien avec la moelle épinière, considérant cela, pour la première fois, comme un milieu poreux imprégné de différents fluides (sang capillaire et veineux et liquide céphalo-rachidien); et un modèle capable d’évaluer le transport d’un médicament dans l’espace sousarachnoïdien, une cavité annulaire remplie de liquide céphalo-rachidien qui entoure la moelle épinière.Avec le troisième modèle proposé, nous entrons dans le système cardiovasculaire.Dans le monde entière, les maladies cardiovasculaires sont la cause principale de mortalité. Parmi ceux-ci, nous trouvons la thrombose, une condition qui implique la formation d’un caillot à l’intérieur d’un vaisseau sanguin, qui peut causer sa occlusion. À cet égard, un modèle numérique a été développé qui étudie la formation et l’évolution des thrombus, en considérant simultanément les aspects chimico-biomécaniques et dynamiques des fluides du problème. Dans le modèle proposé pour la première fois, l'importance du rôle joué par les gradients de contrainte de cisaillement dans le processus de thrombogenèse est pris en compte.Les modèles sélectionnés ont fourni des résultats intéressants. Tout d’abord, l’étude des interactions fluide-structure entre le liquide céphalo-rachidien et la moelle épinière a mis en évidence es conditions pouvant induire l’apparition de la syringomyélie. Il a été observé comment la déviation des valeurs physiologiques du module d’Young de la moelle épinière, les pressions capillaires dans l’interface moelle-espace sousarachnoïdien et la perméabilité des compartiments capillaire et veineux, conduisent à la formation de seringues.Le modèle de calcul pour l’évaluation de la dispersion pharmacologique dans l’espace sousarachnoïdien a permis une estimation quantitatif de la diffusivité effective du médicament, une quantité qui peut aider à l’optimisation des protocoles d’injections intrathécales.Le modèle de thrombogenèse a fourni un instrument capable d’étudier quantitativement l’évolution des dépôts de plaquettes dans la circulation sanguine. En particulier, les résultats ont fourni des informations importantes sur la nécessité de considérer le rôle de l’activation mécanique et de l’agrégation des plaquettes aux côtés de la substance chimique
In the present thesis, three mathematical models are described. Three different biomedical issues, where fluid dynamical aspects are of paramount importance, are modeled: i) Fluid-structure interactions between cerebro-spinal fluid pulsatility and the spinal cord (analytical modeling); ii) Enhanced dispersion of a drug in the subarachnoid space (numerical modeling); and iii) Thrombus formation and evolution in the cardiovascular system (numerical modeling).The cerebrospinal fluid (CSF) is a liquid that surrounds and protects the brain and the spinal cord. Insights into the functioning of cerebrospinal fluid are expected to reveal the pathogenesis of severe neurological diseases, such as syringomyelia that involves the formation of fluid-filled cavities (syrinxes) in the spinal cord.Furthermore, in some cases, analgesic drugs -- as well drugs for treatments of serious diseases such as cancers and cerebrospinal fluid infections -- need to be delivered directly into the cerebrospinal fluid. This underscores the importance of knowing and describing cerebrospinal fluid flow, its interactions with the surrounding tissues and the transport phenomena related to it. In this framework, we have proposed: a model that describes the interactions of the cerebrospinal fluid with the spinal cord that is considered, for the first time, as a porous medium permeated by different fluids (capillary and venous blood and cerebrospinal fluid); and a model that evaluates drug transport within the cerebrospinal fluid-filled space around the spinal cord --namely the subarachnoid space--.The third model deals with the cardiovascular system. Cardiovascular diseases are the leading cause of death worldwide, among these diseases, thrombosis is a condition that involves the formation of a blood clot inside a blood vessel. A computational model that studies thrombus formation and evolution is developed, considering the chemical, bio-mechanical and fluid dynamical aspects of the problem in the same computational framework. In this model, the primary novelty is the introduction of the role of shear micro-gradients into the process of thrombogenesis.The developed models have provided several outcomes. First, the study of the fluid-structure interactions between cerebro-spinal fluid and the spinal cord has shed light on scenarios that may induce the occurrence of Syringomyelia. It was seen how the deviation from the physiological values of the Young modulus of the spinal cord, the capillary pressures at the SC-SAS interface and the permeability of blood networks can lead to syrinx formation.The computational model of the drug dispersion has allowed to quantitatively estimate the drug effective diffusivity, a feature that can aid the tuning of intrathecal delivery protocols.The comprehensive thrombus formation model has provided a quantification tool of the thrombotic deposition evolution in a blood vessel. In particular, the results have given insight into the importance of considering both mechanical and chemical activation and aggregation of platelets
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Smuts, Heidi Esther Marie. "Isotachophoresis of human cerebrospinal fluid." Thesis, University of Cape Town, 1986. http://hdl.handle.net/11427/26160.

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Nikkilä, Heikki. "Cerebrospinal fluid cytology in schizophrenia." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/nikkila/.

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Lebret, Alain. "Study on the cerebrospinal fluid volumes." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST1088/document.

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Cette thèse contribue au manque d'outils informatiques pour l'analyse d'images médicales et le diagnostic, en particulier en ce qui concerne l'étude des volumes du liquide cérébrospinal. La première partie concerne la mesure du volume des compartiments du liquide à partir d'images corps entier, pour une population composée d'adultes sains et de patients atteints d'hydrocéphalie. Les images sont obtenues à partir d'une séquence IRM développée récemment et mettant en évidence le liquide par rapport aux structures voisines, de manière à faciliter sa segmentation. Nous proposons une méthode automatique de segmentation et de séparation des volumes permettant une quantification efficace et reproductible. Le ratio des volumes des compartiments sous-arachnoïdien et ventriculaire est constant chez l'adulte sain, ce qui permet de conserver une pression intracrânienne stable. En revanche, il diminue et varie fortement chez les patients atteints d'hydrocéphalie. Ce ratio fournit un index physiologique fiable pour l'aide au diagnostic de la maladie. La seconde partie de la thèse est consacrée à l'analyse de la distribution du liquide dans le compartiment sous-arachnoïdien intracrânial supérieur. Il convient de souligner que ce compartiment, particulièrement complexe d'un point de vue anatomique, demeure peu étudié. Nous proposons deux techniques de visualisation de la distribution du volume liquidien contenu dans ce compartiment, qui produisent des images bidimensionnelles à partir des images d'origine. Ces images permettent de caractériser la distribution du volume liquidien et de son réseau, tout en distinguant les adultes sains des patients souffrant d'hydrocéphalie
This work aims to contribute to the lack of computational methods for medical image analysis and diagnosis about the study of cerebrospinal fluid volumes. In the first part, we focus on the volume assessment of the fluid spaces, from whole body images, in a population consisting of healthy adults and hydrocephalus patients. To help segmentation, these images, obtained from a recent "tissue-specific" magnetic resonance imaging sequence, highlight cerebrospinal fluid unlike its neigh borhood structures. We propose automatic segmentation and separation methods of the different spaces, which allow efficient and reproducible quantification. We show that the ratio of the total subarachnoid space volume to the ventricular one is a proportionality constant for healthy adults, to support a stable intracranial pressure. However, this ratio decreases and varies significantly among patients suffering from hydrocephalus. This ratio provides a reliable physiological index to help in the diagnosis of hydrocephalus. The second part of this work is dedicated to the fluid volume distribution analysis within the superior cortical subarachnoid space. Anatomical complexity of this space induces that it remains poorly studied. We propose two complementary methods to visualize the fluid volume distribution, and which both produce two-dimensional images from the original ones. These images, called relief maps, are used to characterize respectively, the fluid volume distribution and the fluid network, to classify healthy adults and patients with hydrocephalus, and to perform patient monitoring before and after surgery
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Lebret, Alain, and Alain Lebret. "Study on the cerebrospinal fluid volumes." Phd thesis, Université Paris-Est, 2013. http://tel.archives-ouvertes.fr/tel-00939308.

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This work aims to contribute to the lack of computational methods for medical image analysis and diagnosis about the study of cerebrospinal fluid volumes. In the first part, we focus on the volume assessment of the fluid spaces, from whole body images, in a population consisting of healthy adults and hydrocephalus patients. To help segmentation, these images, obtained from a recent "tissue-specific" magnetic resonance imaging sequence, highlight cerebrospinal fluid unlike its neigh borhood structures. We propose automatic segmentation and separation methods of the different spaces, which allow efficient and reproducible quantification. We show that the ratio of the total subarachnoid space volume to the ventricular one is a proportionality constant for healthy adults, to support a stable intracranial pressure. However, this ratio decreases and varies significantly among patients suffering from hydrocephalus. This ratio provides a reliable physiological index to help in the diagnosis of hydrocephalus. The second part of this work is dedicated to the fluid volume distribution analysis within the superior cortical subarachnoid space. Anatomical complexity of this space induces that it remains poorly studied. We propose two complementary methods to visualize the fluid volume distribution, and which both produce two-dimensional images from the original ones. These images, called relief maps, are used to characterize respectively, the fluid volume distribution and the fluid network, to classify healthy adults and patients with hydrocephalus, and to perform patient monitoring before and after surgery
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Mohammed, Ben Husien. "Endoscopic repair of cerebrospinal fluid leaks." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/27881.

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Developmental Venous Anomalies are a normal variant that may be associated with other cerebral vascular malformation they have bean previously referred to Venous angiomas. DVAs are the most frequently encountered cerebral vascular malformation and their incidence is reported to be high as 2.6%. DVAs are classified into two types based on draining veins. Either deep or superficial. Those that drain into subependymal veins are classified as deep and those that drain into cortical pial veins are classified as superficial. The trans-cerebral veins join either the deep or superficial venous systems by crossing a varying length of the brain parenchyma. Controversy surrounds their exact clinical significance, as DVAs are rarely symptomatic. The symptoms displayed by a patient can be related to a lesion that is associated with DVAs, such as a cavernoma. Study Aim: To describe the patients presenting to a single unit over a 10-year period with symptoms attributable to a DVA. Results: Out of 19 patients in the database with the diagnosis of DVA, 10 were identified where the clinical presentation was directly related to the DVA. Seven of the patients presented with haemorrhage, 6 had parenchymal bleeds and one was intraventricular. Two patients had neurological deficit, 1 was transient and one was progressive. One patient had sudden severe headache with no evidence of haemorrhage on CT scan. The age range was from 14 to 55 with a mean of 32,7 years. Four patients were male and 6 were female. Of the patients that presented with haemorrhage only one had a fistula, three other patients with haemorrhage had evidence on DSA of stenosis of the large collector vein, In the remaining 3 patients no reason for the bleed could be detected. One patient presented with left hemianopia that resolved after several hours, DSA showed minimal caput medusa with delayed filling of the collector vein. The other patient that presented with progressive neurological deficit in the form of progressive leg spasticity and dysarthria, Angiography showed a large collecting vein that drains in the jugular bulb was stenosed. The last patient that presented with sudden sever headaches, with no haemorrhage identified on CT scan, On DSA there was early filling of the DVA veins compared to other cerebral veins and two prominent posterior communicating thalamoperforating vessels were seen. Conclusion: Developmental venous anomalies are the commonest vascular malformation, and are rarely symptomatic unless associated with a cavernoma. In patients that have symptoms linked to DVAs (Haemorrhage, neurological deficit, sudden sever headaches) overall they have a good outcome, and the deficit related to a DVA tend to improve overtime, except for one patient that we had in our group, the DVA draining the pons and the cerebellar hemisphere had a tight outflow stenosis, that lead to progressive neurological deficit. In general, the majority of DVAs that are symptomatic do well.
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Kronander, Björn. "Quantification of alpha-synuclein in cerebrospinal fluid." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84598.

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To date there is no accepted clinical diagnostic test for Parkinson's disease (PD) based on biochemical analyses of blood or cerebrospinal uid. Currently, diagnosis, measurement of disease progression and response to therapeutic intervention are based on clinical observation, but the rst neuronal dysfunction precede the earliest recognition of symptom by at least 5 - 10 years. A potential diagnostic biomarker is oligomeric alpha-synuclein which in recent papers have reported a signicant quantitative dierence between PD and controls. In this master thesis, a method for measuring oligomeric levels of alpha-synuclein is presented together with a monomeric measuring commercial kit used to measure alpha-synuclein in a preclinical model of PD. A signicant dierence of monomeric levels could be detected between two weeks and four weeks post injection of a vector containing the gene for human alpha-synuclein, no signicant dierence between four and eight weeks was found.
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Saugstad, Julie A., Theresa A. Lusardi, Keuren-Jensen Kendall R. Van, Jay I. Phillips, Babett Lind, Christina A. Harrington, Trevor J. McFarland, et al. "Analysis of extracellular RNA in cerebrospinal fluid." TAYLOR & FRANCIS LTD, 2017. http://hdl.handle.net/10150/624656.

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We examined the extracellular vesicle (EV) and RNA composition of pooled normal cerebrospinal fluid (CSF) samples and CSF from five major neurological disorders: Alzheimer's disease (AD), Parkinson's disease (PD), low-grade glioma (LGG), glioblastoma multiforme (GBM), and subarachnoid haemorrhage (SAH), representing neurodegenerative disease, cancer, and severe acute brain injury. We evaluated: (I) size and quantity of EVs by nanoparticle tracking analysis (NTA) and vesicle flow cytometry (VFC), (II) RNA yield and purity using four RNA isolation kits, (III) replication of RNA yields within and between laboratories, and (IV) composition of total and EV RNAs by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and RNA sequencing (RNASeq). The CSF contained similar to 106 EVs/mu L by NTA and VFC. Brain tumour and SAH CSF contained more EVs and RNA relative to normal, AD, and PD. RT-qPCR and RNASeq identified disease-related populations of microRNAs and messenger RNAs (mRNAs) relative to normal CSF, in both total and EV fractions. This work presents relevant measures selected to inform the design of subsequent replicative CSF studies. The range of neurological diseases highlights variations in total and EV RNA content due to disease or collection site, revealing critical considerations guiding the selection of appropriate approaches and controls for CSF studies.
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Books on the topic "Cerebrospiral fluid"

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Teunissen, Charlotte E., and Henrik Zetterberg, eds. Cerebrospinal Fluid Biomarkers. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1319-1.

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Limbrick, David D., and Jeffrey R. Leonard, eds. Cerebrospinal Fluid Disorders. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-97928-1.

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Herndon, Robert M., and Roger A. Brumback, eds. The Cerebrospinal Fluid. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1591-9.

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Kaufman, Howard H. Cerebrospinal fluid collection. Park Ridge, Illinois: Amer. Assoc. of Neurological Surgeons, 1998.

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Santamaría, Enrique, and Joaquín Fernández-Irigoyen, eds. Cerebrospinal Fluid (CSF) Proteomics. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9706-0.

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Ali, Syed Z. Serous Cavity Fluid and Cerebrospinal Fluid Cytopathology. Boston, MA: Springer US, 2012.

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Ali, Syed Z., and Edmund S. Cibas. Serous Cavity Fluid and Cerebrospinal Fluid Cytopathology. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-1776-7.

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Integrated cytology of cerebrospinal fluid. Berlin: Springer, 2008.

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Deisenhammer, Florian, Finn Sellebjerg, Charlotte E. Teunissen, and Hayrettin Tumani, eds. Cerebrospinal Fluid in Clinical Neurology. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-01225-4.

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Martin, Alastair J. H. Cerebrospinal fluid flow in ventriculoperitoneal shunts. Ottawa: National Library of Canada, 1990.

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Book chapters on the topic "Cerebrospiral fluid"

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Siegel, Andrea. "Cerebrospinal Fluid." In Equine Clinical Pathology, 253–69. Chichester, UK: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118718704.ch13.

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Noggle, Chad A. "Cerebrospinal Fluid." In Encyclopedia of Child Behavior and Development, 328. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_508.

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Treves, S. T., L. A. O’Tuama, and A. Kuruc. "Cerebrospinal Fluid." In Pediatric Nuclear Medicine, 109–20. New York, NY: Springer New York, 1995. http://dx.doi.org/10.1007/978-1-4757-4205-3_7.

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Coffman, Keith A., and Miya Asato. "Cerebrospinal Fluid." In Encyclopedia of Autism Spectrum Disorders, 564–66. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_665.

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Mesko, D., and R. Pullmann. "Cerebrospinal Fluid." In Differential Diagnosis by Laboratory Medicine, 393–414. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-642-55600-5_6.

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Ali, Syed Z., and Edmund S. Cibas. "Cerebrospinal Fluid." In Serous Cavity Fluid and Cerebrospinal Fluid Cytopathology, 227–77. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1776-7_10.

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Torre, Matthew. "Cerebrospinal Fluid." In Practical Cytopathology, 143–59. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24059-2_10.

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Aleman, Monica. "Cerebrospinal Fluid." In Interpretation of Equine Laboratory Diagnostics, 393–400. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118922798.ch59.

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Coffman, Keith A., and Miya Asato. "Cerebrospinal Fluid." In Encyclopedia of Autism Spectrum Disorders, 864–66. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_665.

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Treves, S. T., Keasley Welch, and Alvin Kuruc. "Cerebrospinal Fluid." In Pediatric Nuclear Medicine, 223–31. New York, NY: Springer New York, 1985. http://dx.doi.org/10.1007/978-1-4757-1874-4_14.

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Conference papers on the topic "Cerebrospiral fluid"

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Abdullah, Afnizanfaizal, Akihiro Hirayama, Satoshi Yatsushiro, Mitsunori Matsumae, and Kagayaki Kuroda. "Cerebrospinal fluid pulsatile segmentation - a review." In 2012 5th Biomedical Engineering International Conference (BMEiCON). IEEE, 2012. http://dx.doi.org/10.1109/bmeicon.2012.6465494.

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Zheng, Lili, Michael Egnor, and Keith Banninger. "Network Analysis of Cerebrospinal Fluid Dynamics." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23126.

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Abstract Hydrocephalus is a group of life threatening disorders of cerebrospinal fluid flow in and around the brain. It is characterized, in most cases, by accumulation of cerebrospinal fluid in the ventricles of the brain and a progressive increase in pressure in the cranium. The etiology has traditionally been ascribed to an imbalance between the formation and absorption of the cerebrospinal fluid (CSF). Based on this understanding, the treatment is to insert a shunt surgically in order to drain the accumulating fluid in the heart or abdomen. This treatment is invasive and has a high failure rate.
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Bloomfield, Isabelle G. S., Ian H. Johnston, and Lynne E. Bilston. "Effect of Biochemical Composition on Cerebrospinal Fluid Viscosity." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0172.

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Abstract The viscosity of the cerebrospinal fluid has long been assumed to be similar to water but only a handful of studies have measured the rheological properties of this fluid. In the present study the viscosity of cerebrospinal fluid was measured on a rotational rheometer at shear rates from 25 to 1460 sec−1, at 37°C. Each cerebrospinal fluid sample was biochemically analysed and comparisons of viscosity with protein, glucose and blood cell content in the sample were made. Despite the amount of proteins, glucose and blood cells, the viscosity of cerebrospinal fluid remained at a relatively constant level of 0.8mPa.s for the range of shear rate used, at 37°C. These findings were significant using linear regression analysis. It is concluded that cerebrospinal fluid is a newtonian fluid and that its viscosity does not significantly change with its composition.
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Ossipova, E., P. Emami Khoonsari, J. Lengqvist, E. Kosek, D. Kadetoff, P. J. Jakobsson, K. Kultima, and J. Lampa. "AB1064 Exploring cerebrospinal fluid proteome in fibromyalgia." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.5253.

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Englhard, AS, V. Volgger, A. Leunig, and G. Ledderose. "Evaluation of spontaneous nasal cerebrospinal fluid leaks." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640839.

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Staroń, Waldemar, Leszek Herbowski, and Henryk Gurgul. "Microscopic examinations of human cerebrospinal fluid (CSF)." In SPIE Proceedings, edited by Anton Štrba, Dagmar Senderákova, and Miroslav Hrabovský. SPIE, 2005. http://dx.doi.org/10.1117/12.638937.

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Kim, Young-Tak, Hakseung Kim, Dae-Hyeon Park, Xiao ke Yang, Hack-Jin Lee, Eun-Jin Jeong, and Dong-Joo Kim. "Automated phase segmentation in cerebrospinal fluid infusion test." In 2015 3rd International Winter Conference on Brain-Computer Interface (BCI). IEEE, 2015. http://dx.doi.org/10.1109/iww-bci.2015.7073047.

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Lee, Kuan-Ru, Yi-Xian Yeh, Chao-Cheng Wu, Jiannher Lin, and Yung-Hsiao Chiang. "Unsupervised Classification of Cerebrospinal Fluid by Statistical Indicators." In 2018 IEEE International Conference on Systems, Man, and Cybernetics (SMC). IEEE, 2018. http://dx.doi.org/10.1109/smc.2018.00648.

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Pentyala, Srinivas. "Rapid detection of cerebrospinal fluid leaks in trauma." In 2011 Defense Science Research Conference And Expo (DSR). IEEE, 2011. http://dx.doi.org/10.1109/dsr.2011.6026829.

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Miled, Amine. "Thermal effect of dielectrophoresis manipulation on cerebrospinal fluid." In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2014. http://dx.doi.org/10.1109/embc.2014.6945042.

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Reports on the topic "Cerebrospiral fluid"

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Aliev, M. A., A. M. Mamadaliev, and S. A. Mamadalieva. Research of Essential Elements Composition in the Cerebrospinal Fluid in Patients with Outcomes of Traumatic Brain Injury. Innovative Pedagogical Technology, LLC, 2016. http://dx.doi.org/10.17347/5.

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Karantali, Eleni, Dimitrios Kazis, Symela Chatzikonstantinou, Jack McKena, Fivos Petridis, and Ioannis Mavroudis. Cerebrospinal fluid and blood levels of neurofilament light chain in traumatic brain injury: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2020. http://dx.doi.org/10.37766/inplasy2020.10.0031.

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Marenco-Hillembrand, Lina, Michael A. Bamimore, Julio Rosado-Philippi, Blake Perdikis, David N. Abarbanel, Alfredo Quinones-Hinojosa, Kaisorn L. Chaichana, and Wendy J. Sherman. The Evolving Landscape of Leptomeningeal Cancer from Solid Tumors: A Systematic Review of Clinical Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0112.

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Review question / Objective: Among adult patients with leptomeningeal carcinomatosis from solid tumors (population) treated with chemotherapy, targeted therapy, or immunotherapy (intervention and comparator) what are the differences in overall survival (OS) and progression-free survival (PFS) and treatment response based on clinical trial outcomes? Eligibility criteria: Included articles reported 1) human subjects ≥ 18 years 2) diagnosis of leptomeningeal carcinomatosis from solid tumors confirmed by imaging or cerebrospinal fluid (CSF) cytology and clinical or neurological symptoms 3) clinical trials 4) with either PFS or MOS outcomes listed. Book chapters, case reports, review articles, observational studies, ed-itorials, and publications of leptomeningeal cancer from hematological tumors and studies consisting solely of pediatric patients were excluded from the analysis.
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Figueredo, Luisa, Liliana Martinez, and Joao Paulo Almeida. Current role of Endoscopic Endonasal Approach for Craniopharyngiomas. A 10-year Systematic review and Meta-Analysis Comparison with the Open Transcranial Approach. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0045.

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Review question / Objective: To identify and review studies published in the last ten years, presenting the efficacy and outcomes of EEA and TCA for patients with cranio-pharyngiomas. Eligibility criteria: Studies meeting the following criteria were included: (a) retrospective and prospective studies and (b) observational studies (i.e., cross-sectional, case-control, case-series). The outcomes included visual outcomes (improvement, no changes, worsening), endocrinological outcomes (permanent diabetes insipidus and hypopituitarism), operatory site infection, meningitis, cerebrospinal fluid leak, stroke, hemorrhage, and mortality. Studies were excluded if they were determined to be: (a) case-report studies, (b) studies testing genetic disorders, (c) poster presentation abstracts without full-text availability, (d) systematic reviews, and (e) metanalyses.
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Wang, HongZhou, WanHua Wang, HaiCun Shi, LiJian Han, and PingLei Pan. Cerebrospinal fluid and blood levels of neurofilament light chain in Parkinson's disease: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2020. http://dx.doi.org/10.37766/inplasy2020.6.0025.

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Chen, Yue, Huiping Li, and Xilu Chen. A meta-analysis of high mobility group 1 frame protein levels in cerebrospinal fluid and serum of patients with epilepsy. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0029.

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Zhang, Jing, Hongjiang Cheng, Longbin Jia, Wei Liu, and Yi Song. Neurofilament Light Chain in Cerebrospinal Fluid or Blood as a Biomarker for Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2021. http://dx.doi.org/10.37766/inplasy2021.8.0101.

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Ma, Yunxing, Julia Brettschneider, and Joanna Collingwood. A systematic review and meta-analysis of cerebrospinal fluid amyloid and tau levels in patients progressing from Mild Cognitive Impairment to Alzheimer’s Disease. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0020.

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Review question / Objective: Reported levels of amyloid-beta and tau in human cerebrospinal fluid (CSF) are evaluated to discover if these biochemical markers can predict the transition from Mild Cognitive Impairment (MCI) to Alzheimer’s disease (AD). A systematic review and quantitative meta-analyses are performed to test relationships between three potential biomarkers in CSF (Aβ(1-42), T-tau, and P-tau181) and the evolution of AD in longitudinal evaluations of levels relative to baseline, using prior-published experimental data. The primary focus of the analysis is on the period describing the transition of a patient from MCI to AD, where it is critical to discover the main biomarker characteristics that differentiate patient outcomes for those who have a stable form of MCI, and those who progress to a confirmed diagnosis of AD. A secondary purpose of the review was to examine the status of iron in CSF as a function of disease status.
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Shujaa, Asaad Suliman, and Qasem Almulihi. Is Hypertonic Saline an Effective Alternative to Mannitol in the Treatment of TBI in Adult and Pediatric Patients? A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0010.

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Review question / Objective: Evaluate and compare the effectiveness of hypertonic saline and mannitol in patients with traumatic brain injury. Rationale: Traumatic brain injury is one of the main reasons for death and disability worldwide. Generally, the frequency of traumatic brain injury in Europe is >2,000 per million yearly; guidelines suggest more conservative interventions, e.g., raising of the upper body, cerebrospinal fluid drainage, and the use of hypertonic saline or mannitol before executing decompressive craniectomy. It is still uncertain whether hypertonic saline is better than mannitol in managing pediatric and adult patients with traumatic brain injury. The present systemic review and meta-analysis aimed to evaluate the effect of hypertonic saline compared to mannitol for managing TBI in traumatic brain injury. Eligibility criteria: Studies were included based on the described eligibility criteria using PICOS: P (Population); I (Intervention); C (Control); O (Outcome); S (Studies); only clinical trials and cohort studies published in English were selected.
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