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Dissertations / Theses on the topic 'Cerebellum model'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

Gavigan, Thomas. "VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/133.

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Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only

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2

Senatore, Rosa. "The role of basal ganglia and cerebellum in motor learning. A computational model." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/373.

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2010 - 2011<br>Our research activity investigates the computational processes underlying the execution of complex sequences of movements and aims at understanding how different levels of the nervous system interact and contribute to the gradual improvement of motor performance during learning. Many research areas, from neuroscience to engineering, investigate, from different perspectives and for diverse purposes, the processes that allow humans to efficiently perform skilled movements. From a biological point of view, the execution of voluntary movements requires the interaction between

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3

Babenko, Olena Mykolayivna, and University of Lethbridge Faculty of Arts and Science. "The molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat model." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, 2010. http://hdl.handle.net/10133/2604.

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Previous findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the cerebellum. Little is known about the role of the cerebellum in stress-induced behavioural alteration. We hypothesized that alteration in animal behaviour after chronic restraint stress is due to brain-specific changes in miRNA and proteins encoding gene expression. Our results revealed that expression of three miRNAs and 39 mRNAs was changed significantly after two weeks of st

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4

Chintawar, Satyan. "Neural precursor cells: interaction with blood-brain barrier and neuroprotective effect in an animal model of cerebellar degeneration." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210202.

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Adult neural precursor cells (NPCs) are a heterogeneous population of mitotically active, self-renewing multipotent cells of both adult and developing CNS. They can be expanded in vitro in the presence of mitogens. The B05 transgenic SCA1 mice, expressing human ataxin-1 with an expanded polyglutamine tract in cerebellar Purkinje cells (PCs), recapitulate many pathological and behavioral characteristics of the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1), including progressive ataxia and PC loss. We transplanted neural precursor cells (NPCs) derived from the subventricular zon

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5

Takagishi, Yoshiko, 芳子高岸, and Yoshiharu Murata. "Myosin Va mutation in rats is an animal model for the human hereditary neurological disease, Griscelli syndrome type 1." New York Academy of Sciences, 2006. http://hdl.handle.net/2237/10947.

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6

BALDINI, ROSSELLA. "UNDERSTANDING THE MOLECULAR MECHANISMS UNDERLYING THE PATHOGENESIS OF OPITZ G/BBB SYNDROME EXPLOITING THE Mid1 KNOCK-OUT MOUSE MODEL." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2952507.

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Opitz G/BBB syndrome (OS) is a multiple congenital anomaly disorder characterized by developmental defects of midline structures. Mutations in the MID1 gene are responsible of the X-linked form of the syndrome and lead to loss-of-function of the protein. MID1 is an E3 ubiquitin ligase of the tripartite motif (TRIM) subfamily of RING proteins and associates with microtubules. The mouse line carrying a nonfunctional ortholog of the human MID1 gene, Mid1, (Mid1-/Y) recapitulates the brain morphological abnormalities observed in patients, i.e. hypoplasia of the anterior cerebellar vermis, although

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7

Klein, de Licona Hannah Washington. "Congenital LCMV virus: mechanism of brain disease in a rat model of congenital viral infection." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/531.

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Lymphocytic choriomeningitis virus (LCMV) infection during pregnancy severely injures the human fetal brain. Neonatal rats inoculated with LCMV are an excellent model of congenital LCMV infection, as they develop neuropathology, including cerebellar injuries, similar to those seen in humans. The goal of this thesis was to determine what underlies brain injury and the differential immune response and to determine the role of T-cells in LCMV induced pathology. First, I examined whether cytokine and chemokine expression after LCMV infection was higher in the cerebellum and olfactory bulbs, which

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8

Hecker, David [Verfasser]. "Migration of interneuronal precursor cells in the developing cerebellum of mice : model-based cell tracking and simulation / David Hecker." Bonn : Universitäts- und Landesbibliothek Bonn, 2010. http://d-nb.info/1016155654/34.

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9

Balastik, Martin. "Trim2 mutant mice as a model for cerebellar ataxia." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975117025.

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10

MARSHALL, CRAIG ANTHONY. "QUANTITATIVE MEASUREMENT OF THE EXPRESSION OF TWO GENES IN THE CORETX AND CEREBELLUM OF A MOUSE MODEL OF JUVENILE ALZHEIMER’S." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613283.

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There is a continuing effort in order to connect the two neurodegenerative diseases: Alzheimer’s Disease and Niemann-Pick Type C Disease (NPC1) “Juvenile Alzheimer’s”. Here in this study, we attempted to determine if there was a connection through the gene expression in inflammatory genes, CD14 and ETS-1, in a NPC1 mouse model, Npc1nmf164, using quantitative real time PCR. Hydroxypropyl-beta-cyclodextrin (HPβCD) is reported to provide a beneficial effect on NPC1, and there was interest in seeing if HPβCD treatment could return the expression levels to wildtype levels. Instead, only a sig

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11

Parnell, Scott E., Jayanth Ramadoss, Michael D. Delp, et al. "Chronic Ethanol Increases Fetal Cerebral Blood Flow Specific to the Ethanol-Sensitive Cerebellum Under Normoxaemic, Hypercapnic and Acidaemic Conditions: Ovine Model." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/4134.

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Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure causes fetal alcohol spectrum disorder (FASD) in children, but no study had tested this hypothesis using a chronic exposure model that mimicks a common human exposure pattern. Pregnant sheep were exposed to ethanol, 0.75 or 1.75 g kg−1 (to create blood ethanol concentrations of 85 and 185 mg dl−1, respectively), or saline 3 days per week in succession (a ‘binge drinking’ model) from gestational day (GD) 109 until GD 132. Fetuses were instrumented on GD 119–120 and studied on GD 132. The 1.75 g kg−1 dose result

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12

Jaeg, Tiphaine. "Exploring the mitochondrial function in muscle and molecular dysregulation in cerebellum in a mouse model for ARCA2, a recessive ataxia with coenzyme Q10 deficiency." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ082/document.

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ARCA2 est une ataxie autosomique récessive rare, caractérisée par une atrophie du cervelet et un léger déficit en Coenzyme Q10 (CoQ). La majorité des patients présentent des signes neurologiques supplémentaires comme l’épilepsie ou l’intolérance à l’exercice. La maladie est due à des mutations dans le gène COQ8A qui semble encoder une protéine kinase-like atypique, impliquée dans la biosynthèse du CoQ. Pour comprendre les mécanismes physiopathologiques, une souris Coq8a knock-out (KO) constitutif a été générée et récapitule les symptômes observés chez les patients. Le but de ce travail de thès

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13

Maffei, Giovanni. "Automatic and deliberate control of action: an embodied perspective of artificial and biological brains." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/666954.

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Animals evolved to survive in dynamic environments by developing multiple behavioral strategies to adapt and to learn from their interaction with the world. Associative mechanisms and internal representations are at the core brain computation, however, to acquire a complete knowledge of their relevance for behavior it is necessary to take into consideration their embodied nature. In an interdisciplinary effort which integrates methods from computational modeling, robotics, and electrophysiology, this dissertation presents a series of studies that aim at advancing the understanding of the autom

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14

Šuminaite, Daumante. "Elucidating the reversibility of ataxia." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28911.

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Heterozygous and recently identified homozygous mutations in the SPTBN2 gene, encoding b-III spectrin, are implicated in spinocerebellar ataxia type 5 (SCA5) and spectrin-associated autosomal recessive cerebellar ataxia type 1 (SPARCA1), respectively. Our mouse model, lacking b-III spectrin (KO), mimics the progressive human phenotype displaying motor deficiencies as well as reduced Purkinje cell firing frequency followed by dendritic tree degeneration and cell death. The aims of this study were to evaluate progression of Purkinje cell degeneration following loss of b-III spectrin function and

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15

El, Nagar Salsabiel. "Rôle du facteur de transcription Otx2 dans le développement normal et tumoral du cervelet." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4138.

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Les médulloblastomes (MB) sont les tumeurs cérébrales les plus fréquentes en pédiatrie. Ils apparaissent le plus souvent au niveau du cervelet. Ils peuvent être stratifiés en quatre groupes : les groupes WNT et SHH, où ces voies de signalisation sont altérées, et les groupes 3 et 4, présentant des anomalies chromosomiques et amplifications multiples, dont c-Myc (groupe 3) et N-Myc (groupe 4). L’une des altérations génétiques les plus retrouvées dans les MB est la surexpression du facteur de transcription OTX2. Ce facteur est exprimé dans les précurseurs des cellules granulaires (GCP) du cervel

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El, Nagar Salsabiel. "Rôle du facteur de transcription Otx2 dans le développement normal et tumoral du cervelet." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2017. http://theses.univ-cotedazur.fr/2017AZUR4138.

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Les médulloblastomes (MB) sont les tumeurs cérébrales les plus fréquentes en pédiatrie. Ils apparaissent le plus souvent au niveau du cervelet. Ils peuvent être stratifiés en quatre groupes : les groupes WNT et SHH, où ces voies de signalisation sont altérées, et les groupes 3 et 4, présentant des anomalies chromosomiques et amplifications multiples, dont c-Myc (groupe 3) et N-Myc (groupe 4). L’une des altérations génétiques les plus retrouvées dans les MB est la surexpression du facteur de transcription OTX2. Ce facteur est exprimé dans les précurseurs des cellules granulaires (GCP) du cervel

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17

RIZZA, MARTINA FRANCESCA. "Parameter estimation of cerebellar stellate neuron model." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/180709.

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La principale area della mia ricerca è la modellizzazione delle proprietà biofisiche dei neuroni del cervelletto. I modelli computazionali di neuroni sono descrizioni matematiche del loro funzionamento e sono importanti mezzi per lo studio di queste cellule. Saranno presentati i modelli che seguono la notazione matematica di Hodgkin e Huxley (HH) e i modelli descritti secondo la teoria degli Integrate and Fire e infine mi concentrerò sui modelli del cervelletto, essendo questa regione del sistema nervoso centrale il principale interesse della mia ricerca. La prima parte della tesi esamina la

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18

Lu, Song, and 鲁嵩. "Phenotype analysis of Pdss2 conditional knockout mouse." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45552381.

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19

Koontz, Thadeus B. "MCMV induced cerebellar maldevelopment." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/koontz.pdf.

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20

Anderson, Jennifer Louise Medical Sciences Faculty of Medicine UNSW. "Cerebellar synaptic plasticity in two animal models of muscular dystrophy." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43524.

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Duchenne muscular dystrophy (DMD) and congenital muscular dystrophy 1A (MDC1A) are the two most common forms of muscular dystrophy in humans, caused by mutations in dystrophin and laminin α2 genes respectively. Both are severe forms of the disease that lead to premature death due and are both now known to have a significant effect on the central nervous system. This project investigated the role of both proteins involved in each of these diseases in cerebellar Purkinje cells of two murine models of disease: the mdx mouse a dystrophin-deficient model of DMD and the dy2J a laminin α2-deficient m

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21

Matos, Pinto Thiago. "Computational models of intracellular signalling and synaptic plasticity induction in the cerebellum." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/11560.

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Many molecules and the complex interactions between them underlie plasticity in the cerebellum. However, the exact relationship between cerebellar plasticity and the different signalling cascades remains unclear. Calcium-calmodulin dependent protein kinase II (CaMKII) regulates many forms of synaptic plasticity, but very little is known about its function during plasticity induction in the cerebellum. The aim of this thesis is to contribute to a better understanding of the molecular mechanisms that regulate the induction of synaptic plasticity in cerebellar Purkinje cells (PCs). The focus of t

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22

Ortiz, Abalia Jon. "Estudio de los efectos de la reducción de la expresión de Dyrk1A, mediante interferencia de RNA, sobre el fenotipo motor del model transgénico TgDyrk1A. Implantación de kis receptores glutamatérgicos de tipo NMDA." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7188.

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DYRK1A es uno de los principales genes candidatos que podrían explicar algunos de los defectos neurológicos asociados al fenotipo Síndrome de Down (SD); desde el retraso mental, rasgo común a todos los individuos con SD hasta los déficits motores, también muy frecuentes entre la población con SD. Con el fin de validar la implicación de DYRK1A en el fenotipo SD se ha desarrollado una estrategia de terapia génica basada en la reducción de la expresión del gen mediante interferencia del RNA, en el modelo transgénico TgDyrk1A, y se han evaluado los efectos en el fenotipo motor de estos animales. A

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23

Darka, Murat Özdemir Serhan. "The control of a manipulator using cerebellar model articulation controllers/." [s.l.]: [s.n.], 2003. http://library.iyte.edu.tr/tezler/master/makinamuh/T000251.pdf.

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24

Scarfe, Peter Craig. "Error minimising gradients for improving cerebellar model articulation controller performance." Thesis, Curtin University, 2009. http://hdl.handle.net/20.500.11937/1241.

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In motion control applications where the desired trajectory velocity exceeds an actuator’s maximum velocity limitations, large position errors will occur between the desired and actual trajectory responses. In these situations standard control approaches cannot predict the output saturation of the actuator and thus the associated error summation cannot be minimised.An adaptive feedforward control solution such as the Cerebellar Model Articulation Controller (CMAC) is able to provide an inherent level of prediction for these situations, moving the system output in the direction of the excessive

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25

Leroux, Sarah. "Etude des hypoxies périnatales : conception d'outils et effets sur le développement du cervelet chez la souris. Hypoxia is associated with a retardation of cerebellar development and long-term functional deficits in a mouse model of apnea of prematurity." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR100.

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Le cervelet est une région du système nerveux central, située à l’arrière du cerveau et impliquée dans de nombreuses fonctions motrices telles que la coordination ou encore l’équilibre. Des études plus récentes ont également permis de mettre en évidence son implication dans plusieurs fonctions cognitives comme le langage et les processus d’apprentissage. Le cervelet est constitué d’une substance blanche interne et d’une substance grise périphérique appelée cortex cérébelleux. Ce dernier est composé de 4 différentes couches cellulaires lors de la période foetale : la couche granulaire externe (

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ROMANO, FAUSTO. "Evaluation of acute alcohol intoxication as a model of cerebellar disease." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203377.

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The cerebellum is one of the most sensible regions to alcohol effect, since ethanol directly interacts with the functioning of synapses in the cerebellar cortex. Cerebellar patients manifest deficits of cerebellar functions comparable, although stronger, to those experienced by alcohol-intoxicated subjects. Based on such similarities, my work aimed at exploiting the transient cerebellar impairment caused by alcohol in order to model cerebellar diseases, and get new insights on its role in motor control. To achieve this goal, the research activity described in this thesis has concerned the stud

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27

Steuber, Volker. "Computational models of intracellular signalling in cerebellar Purkinje cells." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/21550.

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The aim of this thesis is to contribute to an understanding of the intracellular signalling network that is linked to the activation of metabotropic glutamate receptors (mGluRs) in a cerebellar Purkinje cell. In the thesis, ten different computational models of the mGluR signalling network are mathematically analysed and numerically integrated. The main result of this thesis is that the mGluR signalling network can implement an <I>adaptive time delay</I> between the activation of the mGluRs by glutamate and the release of calcium from intracellular stores. The adaptation of the time delay has

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28

Al-Gonaiah, Majed A. "Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1057/.

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In the last few decades, evidence has been accumulating for a role for xanthine oxidoreductase (XOR)-generated toxic reactive oxygen species (ROS) in a variety of pathological conditions that affect different organ systems. This enzyme in mammals exists in two inter-convertible forms: xanthine dehydrogenase (XDH) (the predominant intracellular form under physiological conditions) and xanthine oxidase (XO). A combination of XO and its oxidizable substrate xanthine (X) (or hypoxanthine (HX)) is widely used as a model to produce ROS and to study their effects in a variety of cell culture studies.

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Anderle, Marica. "Human cerebellar organoids as an in vitro 3D model of Group 3 Medulloblastoma." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/262782.

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Medulloblastoma (MB) is a heterogeneous tumor that represents the most common malignant brain tumor of childhood. It stands as a cause for a high percentage of morbidity and mortality among cancer patients. Thanks to genome-wide analyses, MB can be divided into four significant subgroups, different from each other for diagnosis, prognosis, and metastatic recurrence. WNT subtype has the best prognosis; SHH subtype has an intermediate prognosis; Group 3 subtype is characterized by a high percentage of metastases and worst prognosis; Group 4 MB is the most common subtype, but the less understood.

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Anderle, Marica. "Human cerebellar organoids as an in vitro 3D model of Group 3 Medulloblastoma." Doctoral thesis, Università degli studi di Trento, 2020. http://hdl.handle.net/11572/262782.

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Medulloblastoma (MB) is a heterogeneous tumor that represents the most common malignant brain tumor of childhood. It stands as a cause for a high percentage of morbidity and mortality among cancer patients. Thanks to genome-wide analyses, MB can be divided into four significant subgroups, different from each other for diagnosis, prognosis, and metastatic recurrence. WNT subtype has the best prognosis; SHH subtype has an intermediate prognosis; Group 3 subtype is characterized by a high percentage of metastases and worst prognosis; Group 4 MB is the most common subtype, but the less understood.

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Jo, Sungho 1974. "Application of a model of cerebellar function to the maintenance of human upright posture." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/34345.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.<br>Includes bibliographical references (leaves 82-87).<br>In this thesis a simple human postural control model is suggested and analyzed based on hypothesized neurophysiology of the cerebellar function and the musculoskeletal system. The cerebellum model is made up of simple linear filters such as differentiator and integrator. The simple linear filters implement a linear feedback control scheme including a phase lead compensator. The neural feedback signal represents the action of the cerebellum in th

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Kalia, Lokeshvar Nath. "An investigation of the behaviour of the granular layer of the cerebellum using neuronal and network models." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312830.

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Kaslin, Jan, and Michael Brand. "Cerebellar Development and Neurogenesis in Zebrafish." Springer, 2013. https://tud.qucosa.de/id/qucosa%3A33555.

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Cerebellar organization and function have been studied in numerous species of fish. Fish models such as goldfish and weakly electric fish have led to important findings about the cerebellar architecture, cerebellar circuit physiology and brain evolution. However, most of the studied fish models are not well suited for developmental and genetic studies of the cerebellum. The rapid transparent ex utero development in zebrafish allows direct access and precise visualization of all the major events in cerebellar development. The superficial position of the cerebellar primordium and cerebellum furt

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Ramadoss, Jayanth. "Mechanisms underlying fetal alcohol spectrum disorders: ovine model." 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2660.

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Maternal alcohol abuse during pregnancy can result in a range of structural and functional abnormalities that include lifelong physical, mental, behavioral and learning disabilities, now collectively termed as Fetal Alcohol Spectrum Disorders (FASD). The incidence of FASD is now estimated be as high as 10 per 1000 live births. Each year, 40,000 babies are born with FASD in the United States at an estimated cost of $1.4 million per individual and total cost of $6 billion. Because of the magnitude of this problem and because the incidence has not decreased in spite intensive efforts to educate w

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(8755629), Laura E. Hawley. "Quantifying DYRK1A during perinatal development in the hippocampus, cerebral cortex, and cerebellum of the Ts65Dn mouse model." Thesis, 2020.

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<p>The relationship between gene copy number and protein expression levels has not thoroughly been examined in humans or mouse models of Down syndrome (DS) in relationship to developmental changes in the trisomic brain. Found on human chromosome 21 (Hsa21) and triplicated in DS, Dual-specificity tyrosine-phosphorylated regulated kinase 1A (<i>DYRK1A)</i> has been linked in DS to neurological deficits by restricting cell growth and proliferation. Little information exists regarding DYRK1A during perinatal development and how its expression may lead to cognitive deficits, and none exists that

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BRUNO, FRANCESCO. "Morphofunctional impairment of neuronal and glial cells in the developing cerebellum of a mouse model of Niemann-Pick type C1 disease." Doctoral thesis, 2017. http://hdl.handle.net/11573/986527.

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La malattia di Niemann-Pick di tipo C è un disturbo da accumulo lisosomiale ereditario, causata da mutazioni a carico del gene NPC1 (~95% dei casi) e NPC2 (~5% dei casi). La genetica di tale malattia è molto complessa; attualmente sono state identificate 380 mutazioni a carico del gene NPC1 e 22 a carico del gene NP2. Questi geni codificano per le proteine Npc1 e Npc2 coinvolte nel trasporto intracellulare del colesterolo e di altri lipidi. Infatti, la loro ridotta funzionalità causa un accumulo di colesterolo e altri lipidi, quali sfingosina e i gangliosidi GM2 e GM3, nei compartimenti endo

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Izzo, Mariapaola. "The KCASH2KO mice: a new mouse model with mild cerebellar Hedgehog-dependent phenotype and spermatozoa abnormalities." Doctoral thesis, 2019. http://hdl.handle.net/11573/1269209.

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KCASH2 gene participates in the modulation of the Hedgehog (Hh) pathway, which plays a role in development, embryogenesis and tumorigenesis. In particular, KCASH2 protein prevents the transcriptional Gli1 activity, interacting with the E3 ubiquitin Ligase Cullin 3, mediating histone-deacetylase 1 (HDAC1) ubiquitin-dependent degradation, which would otherwise deacetylate Gli1 enhancing their transcriptional activity. In the present work, we generated KCASH2 knockout mice (KCASH2KO) to evaluate in vivo effect of KCASH2 deletion on the Shh pathway and cerebellar development. KCASH2 expression

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Teles, Magda. "Adult neurogenesis in a new model specie, the cichlid fish Oreochromis mossambicus." Master's thesis, 2010. http://hdl.handle.net/10400.12/4045.

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Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário<br>Em comparação com outros vertebrados, os peixes teleósteos têm um enorme potencial para produzir células novas no cérebro de animais adultos. Em contraste com os mamíferos, onde o processo de neurogénese adulta encontra-se restrito a duas áreas cerebrais, a zona subventricular (SVZ) e a zona subgranular parte do giro dentado do hipocampo, em peixes teleósteos foram descritas mais de 10 regiões neurogénicas. Através da marcação de células mitóticas com 5-bromo-2’-deoxiuridina (BrdU), foram caracterizadas as zonas prolifera

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Yu-Ju, Liu. "Fault Accommodation Using Cerebellar-Model Articulation Controller." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0009-0112200611330190.

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Liu, Yu-Ju, and 劉郁汝. "Fault Accommodation Using Cerebellar-Model Articulation Controller." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/05841755424482700783.

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碩士<br>元智大學<br>電機工程學系<br>92<br>This thesis presents the fault accommodation using Cerebellar-Model Articulation Controller and recurrent Cerebellar-Model Articulation Controller. These controllers are applied to a three-tank system and two engine systems to illustrate their effectiveness. First, a learning architecture, with CMAC network as on-line approximator of the off-nominal system behavior, is used for the accommodation control of two engine systems and a three-tank system. Simulation results show that this method can effectively achieve the fault accommodation. Furthermore, a robust fau

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Chuang, Chih-Ying, and 莊智穎. "STUDY OF PARAMETRIC CEREBELLAR MODEL ARTICULATION CONTROLLER." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99899097621827012510.

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Lin, Tzu-Hua, and 林子華. "A Study on Cerebellar Model Articulation Controller." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/2m53up.

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碩士<br>國立臺北科技大學<br>電機工程系研究所<br>95<br>The PID controller is the longest standing and the most popular controller that has ever been used in the industry because it is convenient and has a simple structure. However, the PID controller can not be used for every system. If the PID controller is used in a more complicated system or in a system where it is not possible to estimate the mathematical model of the plant, then the control performance could be very poor and the plant may not be able to be controlled. In addition, if the parameters of the plant are changed due to external factors, the param

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Hsu, Julie Yong. "The relationship between posterior cerebellum volume and cross-modal divided attention in Autism Spectrum Disorders." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-12-4431.

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The purpose of the current study is to understand the relationship between the volume of the posterior cerebellar hemispheres and cross-modality divided attention in ASD and control participants. Abnormalities in shifting, orienting, and selective attention are well reported in ASD, but few studies have examined divided attention. Furthermore, there is evidence of volumetric reduction of the posterior cerebellum in ASD. However, few studies have examined the relationship between the posterior cerebellum and behavioral performance. The current study addresses this gap in the literature through

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Šalomová, Martina. "Změny motorických funkcí u myšího modelu cerebelární degenerace v průběhu ontogeneze." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-367899.

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The cerebellum affects a number of important and complex processes in the organism. It ensures coordination, motor learning and plays an important role in cognitive and affective functions. In the case of cerebellar degeneration, we find not only the movement disorders but also behavioral abnormalities, collectively referred to as cognitive-affective syndrome. The aim of this work was to investigate motor functions during ontogenesis in animal models of hereditary cerebellar degeneration - mutant mice Lurcher and Purkinje cell degeneration using the device for quantitative gait analysis and ro

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Lu, Wei-Ting, and 呂韋廷. "Deadzone compensation based on Cerebellar Model Articulation Controller." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/82472173577771948228.

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碩士<br>龍華科技大學<br>工程技術研究所<br>100<br>In this paper, the utilization of adaptive control and Cerebellar Model Articulation Controller is the compensation of the phenomenon of Non-Linear Deadzone which is in Servo-Hydraulic System. In addition, the controlled-dynamical model is separated into Non-Linear Deadzone System and Linear Time-Invariant System. In the systems, there are two Cerebellar Model Articulation Controller; One is for identifying the parameters of Deadzone, then the result is used to train the other one which is used for the inverse compensation of Deadzone that is employed to elimi

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Chi-Jui, Kao. "Intelligent Car-Following Control Using Cerebellar Model Articulation Controller." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0009-0112200611330076.

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Lin, Ming-Hung, and 林明宏. "Design and Applications of Robust Cerebellar Model Articulation Controller." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/57069450746764653910.

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碩士<br>清雲科技大學<br>電機工程研究所<br>94<br>In this thesis the cerebellar model articulation controller (CMAC) is the main controller. First , since the dynamic characteristics of the linear piezoelectric ceramic motor (LPCM) are highly nonlinear and time varying, it is difficult to design a suitable motor position controller to achieve high-precision position control at all time. An robust cerebellar model articulation controller (CMAC) via the backstepping control technique is proposed. In the robust CMAC backstepping control system, an adaptive CMAC is used to mimic an ideal backstepping control law a

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Kao, Chi-Jui, and 高啟瑞. "Intelligent Car-Following Control Using Cerebellar Model Articulation Controller." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/41258903770963265558.

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碩士<br>元智大學<br>電機工程學系<br>92<br>The application of new technologies of computer and communications on the transportation vehicle can improve the vehicle safety and accelerate the vehicle performance dramatically. Also, the vehicle can communicate with all other information suppliers at any time. This is called the Intelligent Vehicle (IV). This thesis focuses on the design of the cerebellar model articulation controller (CMAC) based on adaptive control, supervisory control and recursive control, which attempt to provide a comprehensive treatment of CMACs in closed-loop control applica

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Lan, Shih-Wei, and 藍世緯. "Adaptive Echo Cancellation Using Deep Cerebellar Model Articulation Controller." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/80404587248894079955.

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碩士<br>元智大學<br>電機工程學系<br>105<br>ABSTRACT It had the very big breakthrough in the machine learning development in recent years. No matter the Watson which developed by IBM or Google’s AlphaGo, they both are based on depth of neural networks. And the cerebellar model articulation controller (CMAC) has been widely used in various applications of neural networks, such as: inverted pendulum, nonlinear channel equalization and robot control. It has great generalization and learning fast characteristics enough to deal with the basic applications of neural network. But if the complexity of the higher

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Lin, Shou-Chuang, and 林首壯. "High Performance PID-type Cerebellar Model Articulation Controller Design." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/t6rks5.

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碩士<br>國立臺北科技大學<br>電機工程系所<br>94<br>As modeling the physical systems to meet the need of control purpose, finding mathematical models of these systems is a challenging work, and there are many approaches proposed to solve this problem. To reduce the complexity of analysis, model reduction and linearization techniques are frequently adopted. Also, insignificant parameters or inferences are sometimes neglected during the modeling process. Though using the forgoing obtained mathematical models can easily and quickly calculate the control force, in some circumstances, the control behavior of simulat

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