Academic literature on the topic 'Cerebellum model'

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Journal articles on the topic "Cerebellum model"

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Mitoma, Hiroshi, Mario Manto, and Aasef G. Shaikh. "Alcohol Toxicity in the Developing Cerebellum." Diagnostics 14, no. 13 (2024): 1415. http://dx.doi.org/10.3390/diagnostics14131415.

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The impact of ethanol on the fetus is a significant concern as an estimated 2–5% of live births may be affected by prenatal alcohol exposure. This exposure can lead to various functional and structural abnormalities in the cerebral cortex, basal ganglia, diencephalon, and cerebellum, resulting in region-specific symptoms. The deficits relate to the motor and cognitive domains, affecting, in particular, general intelligence, attention, executive functions, language, memory, visual perception, and social skills—collectively called the fetal alcohol spectrum disorder (FASD). Recent studies sugges
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Mwachaka, Philip Maseghe, Peter Gichangi, Adel Abdelmalek, Paul Odula, and Julius Ogeng’o. "Effect of Maternal Folate Use on Offsprings' Cerebellar Morphometric Parameters: An Experimental Study in A Rat Model." International Journal of Anatomy and Research 11, no. 3 (2023): 8685–91. http://dx.doi.org/10.16965/ijar.2023.161.

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Background: Folate is an important nutrient in fetal and early postnatal brain development, and its supplementation during pregnancy has been widely recommended. Folate supplementation has been linked to improved cerebellar function, specifically motor and neuropsychological abilities. It is still unclear exactly how folate affects the cerebellum's structural growth. This study aimed to describe the effects of maternal folate use on cerebellum postnatal development. Methods: Twelve adults (6–8 week old) female rats (Rattus norwegicus) were randomly divided into four groups and fed one of four
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Kotani, Osamu, Tadaki Suzuki, Masaru Yokoyama, et al. "Intracerebral Inoculation of Mouse-Passaged Saffold Virus Type 3 Affects Cerebellar Development in Neonatal Mice." Journal of Virology 90, no. 21 (2016): 10007–21. http://dx.doi.org/10.1128/jvi.00864-16.

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ABSTRACTSaffold virus (SAFV), a human cardiovirus, is occasionally detected in infants with neurological disorders, including meningitis and cerebellitis. We recently reported that SAFV type 3 isolates infect cerebellar glial cells, but not large neurons, in mice. However, the impact of this infection remained unclear. Here, we determined the neuropathogenesis of SAFV type 3 in the cerebella of neonatal ddY mice by using SAFV passaged in the cerebella of neonatal BALB/c mice. The virus titer in the cerebellum increased following the inoculation of each of five passaged strains. The fifth passa
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Kiffmeyer, Elizabeth A., Jameson A. Cosgrove, Jenna K. Siganos, et al. "Deficits in Cerebellum-Dependent Learning and Cerebellar Morphology in Male and Female BTBR Autism Model Mice." NeuroSci 3, no. 4 (2022): 624–44. http://dx.doi.org/10.3390/neurosci3040045.

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Recently, there has been increased interest in the role of the cerebellum in autism spectrum disorder (ASD). To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3tf/J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. When we examined both male and female BTBR mice
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Pollok, Bettina, Joachim Gross, Daniel Kamp, and Alfons Schnitzler. "Evidence for Anticipatory Motor Control within a Cerebello-Diencephalic-Parietal Network." Journal of Cognitive Neuroscience 20, no. 5 (2008): 828–40. http://dx.doi.org/10.1162/jocn.2008.20506.

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The posterior parietal cortex and the cerebellum are assumed to contribute to anticipatory motor control. Thus, it is reasonable that these areas act as a functional unit. To identify a neural signature of anticipatory motor control, 11 healthy volunteers performed a bimanual finger-tapping task with respect to isochronous (i.e., regular) and randomized (i.e., irregular) auditory pacing. Neuromagnetic activity was recorded using a 122-channel whole-head neuromagnetometer. Functional interaction between spatially distributed brain areas was determined by measures of tap-related phase synchroniz
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Kim, Jusik, Keeeun Kim, Jung-soon Mo та Youngsoo Lee. "Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation". Nucleic Acids Research 48, № 7 (2020): 3678–91. http://dx.doi.org/10.1093/nar/gkaa140.

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Abstract Genomic instability resulting from defective DNA damage responses or repair causes several abnormalities, including progressive cerebellar ataxia, for which the molecular mechanisms are not well understood. Here, we report a new murine model of cerebellar ataxia resulting from concomitant inactivation of POLB and ATM. POLB is one of key enzymes for the repair of damaged or chemically modified bases, including methylated cytosine, but selective inactivation of Polb during neurogenesis affects only a subpopulation of cortical interneurons despite the accumulation of DNA damage throughou
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Knolle, Franziska, Erich Schröger, Pamela Baess, and Sonja A. Kotz. "The Cerebellum Generates Motor-to-Auditory Predictions: ERP Lesion Evidence." Journal of Cognitive Neuroscience 24, no. 3 (2012): 698–706. http://dx.doi.org/10.1162/jocn_a_00167.

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Forward predictions are crucial in motor action (e.g., catching a ball, or being tickled) but may also apply to sensory or cognitive processes (e.g., listening to distorted speech or to a foreign accent). According to the “internal forward model,” the cerebellum generates predictions about somatosensory consequences of movements. These predictions simulate motor processes and prepare respective cortical areas for anticipated sensory input. Currently, there is very little evidence that a cerebellar forward model also applies to other sensory domains. In the current study, we address this questi
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Omotoso, Gabriel Olaiya, Leviticus Oghenevurinrin Arietarhire, Ileje Inelo Ukwubile, and Ismail Temitayo Gbadamosi. "The Protective Effect of Kolaviron on Molecular, Cellular, and Behavioral Characterization of Cerebellum in the Rat Model of Demyelinating Diseases." Basic and Clinical Neuroscience Journal 11, no. 5 (2020): 609–18. http://dx.doi.org/10.32598/bcn.9.10.300.

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Introduction: This study aimed at assessing the protective mechanisms of Kolaviron (KV) on the cerebellum in a rat model of demyelination. Methods: Twenty-eight male Wistar rats were used in the present study. They were randomly divided into 4 groups of 7 rats. Group A (control) received corn oil (0.5 mL/kg/d); group B received 0.2% Cuprizone (CPZ); group C was treated with 200 mg/kg/d of KV, and group D received 0.2% CPZ and 200 mg/kg/d KV for 6 weeks. CPZ powder was mixed with the regular diet while KV was dissolved in corn oil and administered orally. A behavioral test was conducted at the
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Liu, Qi, Chang Liu, Yu Chen, and Yumei Zhang. "Cognitive Dysfunction following Cerebellar Stroke: Insights Gained from Neuropsychological and Neuroimaging Research." Neural Plasticity 2022 (April 15, 2022): 1–11. http://dx.doi.org/10.1155/2022/3148739.

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Although the cerebellum has been consistently noted in the process of cognition, the pathophysiology of this link is still under exploration. Cerebellar stroke, in which the lesions are focal and limited, provides an appropriate clinical model disease for studying the role of the cerebellum in the cognitive process. This review article targeting the cerebellar stroke population (1) describes a cognitive impairment profile, (2) identifies the cerebellar structural alterations linked to cognition, and (3) reveals possible mechanisms of cerebellar cognition using functional neuroimaging. The data
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Geminiani, Alice, Claudia Casellato, Alberto Antonietti, Egidio D’Angelo, and Alessandra Pedrocchi. "A Multiple-Plasticity Spiking Neural Network Embedded in a Closed-Loop Control System to Model Cerebellar Pathologies." International Journal of Neural Systems 28, no. 05 (2018): 1750017. http://dx.doi.org/10.1142/s0129065717500174.

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The cerebellum plays a crucial role in sensorimotor control and cerebellar disorders compromise adaptation and learning of motor responses. However, the link between alterations at network level and cerebellar dysfunction is still unclear. In principle, this understanding would benefit of the development of an artificial system embedding the salient neuronal and plastic properties of the cerebellum and operating in closed-loop. To this aim, we have exploited a realistic spiking computational model of the cerebellum to analyze the network correlates of cerebellar impairment. The model was modif
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Dissertations / Theses on the topic "Cerebellum model"

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Gavigan, Thomas. "VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/133.

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Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only
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Senatore, Rosa. "The role of basal ganglia and cerebellum in motor learning. A computational model." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/373.

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2010 - 2011<br>Our research activity investigates the computational processes underlying the execution of complex sequences of movements and aims at understanding how different levels of the nervous system interact and contribute to the gradual improvement of motor performance during learning. Many research areas, from neuroscience to engineering, investigate, from different perspectives and for diverse purposes, the processes that allow humans to efficiently perform skilled movements. From a biological point of view, the execution of voluntary movements requires the interaction between
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Babenko, Olena Mykolayivna, and University of Lethbridge Faculty of Arts and Science. "The molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat model." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010, 2010. http://hdl.handle.net/10133/2604.

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Previous findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the cerebellum. Little is known about the role of the cerebellum in stress-induced behavioural alteration. We hypothesized that alteration in animal behaviour after chronic restraint stress is due to brain-specific changes in miRNA and proteins encoding gene expression. Our results revealed that expression of three miRNAs and 39 mRNAs was changed significantly after two weeks of st
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Chintawar, Satyan. "Neural precursor cells: interaction with blood-brain barrier and neuroprotective effect in an animal model of cerebellar degeneration." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210202.

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Adult neural precursor cells (NPCs) are a heterogeneous population of mitotically active, self-renewing multipotent cells of both adult and developing CNS. They can be expanded in vitro in the presence of mitogens. The B05 transgenic SCA1 mice, expressing human ataxin-1 with an expanded polyglutamine tract in cerebellar Purkinje cells (PCs), recapitulate many pathological and behavioral characteristics of the neurodegenerative disease spinocerebellar ataxia type 1 (SCA1), including progressive ataxia and PC loss. We transplanted neural precursor cells (NPCs) derived from the subventricular zon
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Takagishi, Yoshiko, 芳子 高岸, and Yoshiharu Murata. "Myosin Va mutation in rats is an animal model for the human hereditary neurological disease, Griscelli syndrome type 1." New York Academy of Sciences, 2006. http://hdl.handle.net/2237/10947.

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BALDINI, ROSSELLA. "UNDERSTANDING THE MOLECULAR MECHANISMS UNDERLYING THE PATHOGENESIS OF OPITZ G/BBB SYNDROME EXPLOITING THE Mid1 KNOCK-OUT MOUSE MODEL." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2952507.

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Opitz G/BBB syndrome (OS) is a multiple congenital anomaly disorder characterized by developmental defects of midline structures. Mutations in the MID1 gene are responsible of the X-linked form of the syndrome and lead to loss-of-function of the protein. MID1 is an E3 ubiquitin ligase of the tripartite motif (TRIM) subfamily of RING proteins and associates with microtubules. The mouse line carrying a nonfunctional ortholog of the human MID1 gene, Mid1, (Mid1-/Y) recapitulates the brain morphological abnormalities observed in patients, i.e. hypoplasia of the anterior cerebellar vermis, although
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Klein, de Licona Hannah Washington. "Congenital LCMV virus: mechanism of brain disease in a rat model of congenital viral infection." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/531.

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Lymphocytic choriomeningitis virus (LCMV) infection during pregnancy severely injures the human fetal brain. Neonatal rats inoculated with LCMV are an excellent model of congenital LCMV infection, as they develop neuropathology, including cerebellar injuries, similar to those seen in humans. The goal of this thesis was to determine what underlies brain injury and the differential immune response and to determine the role of T-cells in LCMV induced pathology. First, I examined whether cytokine and chemokine expression after LCMV infection was higher in the cerebellum and olfactory bulbs, which
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Hecker, David [Verfasser]. "Migration of interneuronal precursor cells in the developing cerebellum of mice : model-based cell tracking and simulation / David Hecker." Bonn : Universitäts- und Landesbibliothek Bonn, 2010. http://d-nb.info/1016155654/34.

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Balastik, Martin. "Trim2 mutant mice as a model for cerebellar ataxia." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975117025.

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MARSHALL, CRAIG ANTHONY. "QUANTITATIVE MEASUREMENT OF THE EXPRESSION OF TWO GENES IN THE CORETX AND CEREBELLUM OF A MOUSE MODEL OF JUVENILE ALZHEIMER’S." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613283.

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There is a continuing effort in order to connect the two neurodegenerative diseases: Alzheimer’s Disease and Niemann-Pick Type C Disease (NPC1) “Juvenile Alzheimer’s”. Here in this study, we attempted to determine if there was a connection through the gene expression in inflammatory genes, CD14 and ETS-1, in a NPC1 mouse model, Npc1nmf164, using quantitative real time PCR. Hydroxypropyl-beta-cyclodextrin (HPβCD) is reported to provide a beneficial effect on NPC1, and there was interest in seeing if HPβCD treatment could return the expression levels to wildtype levels. Instead, only a sig
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Books on the topic "Cerebellum model"

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David, Rogers, and Research Institute for Advanced Computer Science (U.S.), eds. Temporal learning in the cerebellum: The MicroCircuit model. Research Institute for Advanced Computer Science, NASA Ames Research Center, 1990.

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Eskandarian, Azim. A reference model dynamics-CMAC algorithm for simulation and control of robotic manipulators. George Washington University, 1991.

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Randolph, Raugh Michael, Ames Research Center, Research Institute for Advanced Computer Science (U.S.), and Compcon (34th : 1989 : San Francisco, Calif.), eds. Cerebellar models of associative memory: Three papers from IEEE COMPCON Spring '89. Research Institute for Advanced Computer Science, NASA Ames Research Center, 1989.

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Ely, Budding Deborah, ed. Subcortical structures and cognition: Implications for neuropsychological assessment. Springer, 2009.

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Mason, Peggy. Cerebellum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0024.

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The cerebellum uses sensory feedback and information about intended actions to ensure coordinated and smooth movements despite changing conditions. An analogy between the cerebellum and an orchestral conductor is elaborated. The cerebellum’s involvement in forming and executing motor memories is presented. Cerebellar circuits through the cerebellar cortex and deep nuclei and the dependence of cerebellar learning on climbing fiber input to Purkinje cells are briefly described. Sensory reafference and motor efference copy are defined and their roles in coordinating movement introduced. Cerebella
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Soong, Bing-wen. Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies. Springer International Publishing AG, 2023.

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Berman, Frederick W. Development and characterization of a model of glutamate and domoate toxicity in cultured rat cerebellar granule neurons. 1997.

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Koziol, Leonard F., and Deborah Ely Budding. Subcortical Structures and Cognition: Implications for Neuropsychological Assessment. Springer New York, 2010.

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McLachlan, Neil M. Timbre, Pitch, and Music. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199935345.013.44.

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The perception of a sound’s timbre and pitch may be related to the more basic auditory function of sound recognition. Timbre may be related to the sensory experience (or memory) by which we recognize the source or meaning of a sound, while pitch may involve the recognition and mapping of timbres along a cognitive spatial dimension. Musical dissonance may then result from failure of sound recognition mechanisms, resulting in poor integration of pitch information and heightened arousal in musicians. Neurobiological models of auditory processing that include cortico-ponto-cerebellar and limbic pa
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Faraone, Stephen V., Pradeep G. Bhide, and Joseph Biederman. Neurobiology of Attention Deficit Hyperactivity Disorder. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0064.

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Attention deficit hyperactivity disorder (ADHD) is a prevalent, early-onset and persistent disorder of inattention, hyperactivity, and impulsivity. The mechanisms of action of ADHD medications, neuroimaging studies, and studies of monoamine systems and animal models suggest that dysregulation of catecholaminergic neurotransmission in cerebellar-corticostriatal circuits plays a key role in the pathophysiology of ADHD. The efficacy of ADHD medications likely arises from their differing profile of effects on (a) dopaminergic and noradrenergic systems and (b) the localization of these effects in p
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Book chapters on the topic "Cerebellum model"

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Koziol, Leonard F., Deborah Ely Budding, and Dana Chidekel. "The Cerebellum." In ADHD as a Model of Brain-Behavior Relationships. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8382-3_18.

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Zhan, Xiaoqin, and Ray W. Turner. "Restoring a Loss of Mossy Fiber Plasticity in a Model of Fragile X Syndrome." In Essentials of Cerebellum and Cerebellar Disorders. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-15070-8_48.

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Travis, Bryan J. "A Computational Model of the Cerebellum." In Analysis and Modeling of Neural Systems. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-4010-6_14.

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Houk, J. C. "Model of the Cerebellum as an Array Of Adjustable Pattern Generators." In Cerebellum and Neuronal Plasticity. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-0965-9_16.

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Koziol, Leonard F., Deborah Ely Budding, and Dana Chidekel. "The Modular Organization of the Cerebellum." In ADHD as a Model of Brain-Behavior Relationships. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-8382-3_19.

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Zhang, Shaobai, and Qun Chen. "Study over Cerebellum Prediction Model During Hand Tracking." In Communications in Computer and Information Science. Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-3966-9_17.

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Antonietti, Alberto, Claudia Casellato, Egidio D’Angelo, and Alessandra Pedrocchi. "Computational Modelling of Cerebellar Magnetic Stimulation: The Effect of Washout." In Lecture Notes in Computer Science. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82427-3_3.

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AbstractNowadays, clinicians have multiple tools that they can use to stimulate the brain, by means of electric or magnetic fields that can interfere with the bio-electrical behaviour of neurons. However, it is still unclear which are the neural mechanisms that are involved and how the external stimulation changes the neural responses at network-level. In this paper, we have exploited the simulations carried out using a spiking neural network model, which reconstructed the cerebellar system, to shed light on the underlying mechanisms of cerebellar Transcranial Magnetic Stimulation affecting sp
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Sotelo, Constantino. "Cerebellar Transplantation: A Potential Model to Study Repair and Development of Neurons and Circuits in the Cerebellum." In Development of the Cerebellum from Molecular Aspects to Diseases. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-59749-2_22.

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Wang, Xin, Peng Yu, Mingzhi Mao, and Ning Tan. "A Cerebellum-Inspired Model-Free Kinematic Control Method with RCM Constraint." In Neural Information Processing. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-30108-7_12.

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Pessac, Bernard, and Françoise Alliot. "Do Mouse Cerebellum Astrocytes Play a Role in Neuronal Survival and Differentiation?" In Model Systems of Development and Aging of the Nervous System. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-2037-1_14.

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Conference papers on the topic "Cerebellum model"

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Kawato, M., and H. Gomi. "Model of four regions of the cerebellum." In 1991 IEEE International Joint Conference on Neural Networks. IEEE, 1991. http://dx.doi.org/10.1109/ijcnn.1991.170436.

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"Brain-inspired Sensorimotor Robotic Platform - Learning in Cerebellum-driven Movement Tasks through a Cerebellar Realistic Model." In Special Session on Challenges in Neuroengineering. SCITEPRESS - Science and and Technology Publications, 2013. http://dx.doi.org/10.5220/0004659305680573.

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Zhang Shao-bai, Ruan Xiao-gang, and Cheng Xiefeng. "A new constructing method of cerebellum model applying to DIVA model." In 2009 Chinese Control and Decision Conference (CCDC). IEEE, 2009. http://dx.doi.org/10.1109/ccdc.2009.5192809.

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Zhou, Chenye, and Shaobai Zhang. "Research on timing function of cerebellum in DIVA model." In International Conference on Communication Technology. WIT Press, 2014. http://dx.doi.org/10.2495/icct130381.

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Mathew, Seema, Parimal Giri, and Manjusha Agwan. "A Simulink Implementation of the Cerebellum Model Articulation Controller." In 2010 Second International Conference on Advances in Computing, Control and Telecommunication Technologies (ACT). IEEE, 2010. http://dx.doi.org/10.1109/act.2010.47.

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Presannan, Anandhu, Arathi Rajendran, Bipin Nair, and Shyam Diwakar. "Reproducing the Firing Properties of a Cerebellum Deep Cerebellar Nucleus with a Multi-Compartmental Morphologically Realistic Biophysical Model." In 2018 International Conference on Advances in Computing, Communications and Informatics (ICACCI). IEEE, 2018. http://dx.doi.org/10.1109/icacci.2018.8554491.

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Luo, Junwen, Graeme Coapes, Patrick Degenaar, Tadashi Yamazaki, Terrence Mak, and Chung Tin. "A real-time silicon cerebellum spiking neural model based on FPGA." In 2014 International Symposium on Integrated Circuits (ISIC). IEEE, 2014. http://dx.doi.org/10.1109/isicir.2014.7029586.

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Yoosef, Afila, Harilal Parasuram, Chaitanya Medini, et al. "Parallelization of a Computational Model of a Biophysical Neuronal Circuitry of Rat Cerebellum." In the 2014 International Conference. ACM Press, 2014. http://dx.doi.org/10.1145/2660859.2660962.

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Geminiani, Alice, Aurimas Mockevicius, Egidio D'Angelo, and Claudia Casellato. "Cerebellum involvement in dystonia: insights from a spiking neural network model during associative learning." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871205.

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Reyes López, Misael, Fernando Arámbula Cosío, Boris Escalante Ramírez, and Jimena Olveres Montiel. "Shape model and Hermite features for the segmentation of the cerebellum in fetal ultrasound." In 14th International Symposium on Medical Information Processing and Analysis, edited by Eduardo Romero, Natasha Lepore, and Jorge Brieva. SPIE, 2018. http://dx.doi.org/10.1117/12.2511411.

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Reports on the topic "Cerebellum model"

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Gambello, Michael. Behavioral Analysis and Rescue of a Novel Cerebellar Mouse Model of Tuberous Sclerosis Complex. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada566012.

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