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Journal articles on the topic 'Centrifugal Microfluidics'

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Author: Grafiati

Published: 6 September 2023

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1

Schwarz, I., S. Zehnle, T. Hutzenlaub, R. Zengerle, and N. Paust. "System-level network simulation for robust centrifugal-microfluidic lab-on-a-chip systems." Lab on a Chip 16, no. 10 (2016): 1873–85. http://dx.doi.org/10.1039/c5lc01525a.

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2

Schwemmer, F., S. Zehnle, D. Mark, F. von Stetten, R. Zengerle, and N. Paust. "A microfluidic timer for timed valving and pumping in centrifugal microfluidics." Lab on a Chip 15, no. 6 (2015): 1545–53. http://dx.doi.org/10.1039/c4lc01269k.

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3

Vargas, Matheus J. T., Michel K. Nieuwoudt, Rakesh Arul, David E. Williams, and M. Cather Simpson. "Direct laser writing of hydrophobic and hydrophilic valves in the same material applied to centrifugal microfluidics." RSC Advances 13, no. 32 (2023): 22302–14. http://dx.doi.org/10.1039/d3ra01749d.

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The fabrication of hydrophobic and hydrophilic surfaces, achieved using femtosecond and nanosecond laser treatments, and their subsequent integration into centrifugal microfluidics, resulted in a noticeable improvement in operation of microfluidic valves.

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4

Xie, Zhongqiang, Yongchao Cai, Jiahao Wu, Zhaokun Xian, and Hui You. "Research on the Centrifugal Driving of a Water-in-Oil Droplet in a Microfluidic Chip with Spiral Microchannel." Applied Sciences 12, no. 9 (April 26, 2022): 4362. http://dx.doi.org/10.3390/app12094362.

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Combining the advantages of droplet-based microfluidics and centrifugal driving, a method for centrifugally driving W/O droplets with spiral microchannel is proposed in this paper. A physical model of droplet flow was established to study the flow characteristics of the W/O droplet in the spiral microchannel driven by centrifugal force, and kinematic analysis was performed based on the rigid body assumption. Then, the theoretical formula of droplet flow rate was obtained. The theoretical value was compared with the actual value measured in the experiments. The result shows that the trend of the theoretical value is consistent with the measured value, and the theoretical value is slightly larger than the experimentally measured value caused by deformation. Moreover, it is found that the mode of centrifugal driving with spiral microchannel has better flow stability than the traditional centrifugal driving structure. A larger regulation speed range can be achieved by adjusting the motor speed without using expensive equipment or precise instruments. This study can provide a basis and theoretical reference for the development of droplet-based centrifugal microfluidic chips.

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5

Xie, Zhongqiang, Yongchao Cai, Jiahao Wu, Zhaokun Xian, and Hui You. "Research on the Centrifugal Driving of a Water-in-Oil Droplet in a Microfluidic Chip with Spiral Microchannel." Applied Sciences 12, no. 9 (April 26, 2022): 4362. http://dx.doi.org/10.3390/app12094362.

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Combining the advantages of droplet-based microfluidics and centrifugal driving, a method for centrifugally driving W/O droplets with spiral microchannel is proposed in this paper. A physical model of droplet flow was established to study the flow characteristics of the W/O droplet in the spiral microchannel driven by centrifugal force, and kinematic analysis was performed based on the rigid body assumption. Then, the theoretical formula of droplet flow rate was obtained. The theoretical value was compared with the actual value measured in the experiments. The result shows that the trend of the theoretical value is consistent with the measured value, and the theoretical value is slightly larger than the experimentally measured value caused by deformation. Moreover, it is found that the mode of centrifugal driving with spiral microchannel has better flow stability than the traditional centrifugal driving structure. A larger regulation speed range can be achieved by adjusting the motor speed without using expensive equipment or precise instruments. This study can provide a basis and theoretical reference for the development of droplet-based centrifugal microfluidic chips.

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6

Shi, Yuxing, Peng Ye, Kuojun Yang, Jie Meng, Jiuchuan Guo, Zhixiang Pan, Qiaoge Bayin, and Wenhao Zhao. "Application of Microfluidics in Immunoassay: Recent Advancements." Journal of Healthcare Engineering 2021 (July 15, 2021): 1–24. http://dx.doi.org/10.1155/2021/2959843.

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In recent years, point-of-care testing has played an important role in immunoassay, biochemical analysis, and molecular diagnosis, especially in low-resource settings. Among various point-of-care-testing platforms, microfluidic chips have many outstanding advantages. Microfluidic chip applies the technology of miniaturizing conventional laboratory which enables the whole biochemical process including reagent loading, reaction, separation, and detection on the microchip. As a result, microfluidic platform has become a hotspot of research in the fields of food safety, health care, and environmental monitoring in the past few decades. Here, the state-of-the-art application of microfluidics in immunoassay in the past decade will be reviewed. According to different driving forces of fluid, microfluidic platform is divided into two parts: passive manipulation and active manipulation. In passive manipulation, we focus on the capillary-driven microfluidics, while in active manipulation, we introduce pressure microfluidics, centrifugal microfluidics, electric microfluidics, optofluidics, magnetic microfluidics, and digital microfluidics. Additionally, within the introduction of each platform, innovation of the methods used and their corresponding performance improvement will be discussed. Ultimately, the shortcomings of different platforms and approaches for improvement will be proposed.

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7

Burger, Robert, Daniel Kirby, Macdara Glynn, Charles Nwankire, Mary O'Sullivan, Jonathan Siegrist, David Kinahan, et al. "Centrifugal microfluidics for cell analysis." Current Opinion in Chemical Biology 16, no. 3-4 (August 2012): 409–14. http://dx.doi.org/10.1016/j.cbpa.2012.06.002.

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8

Gorkin, Robert, Jiwoon Park, Jonathan Siegrist, Mary Amasia, Beom Seok Lee, Jong-Myeon Park, Jintae Kim, Hanshin Kim, Marc Madou, and Yoon-Kyoung Cho. "Centrifugal microfluidics for biomedical applications." Lab on a Chip 10, no. 14 (2010): 1758. http://dx.doi.org/10.1039/b924109d.

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9

Pishbin, Esmail, Amin Kazemzadeh, Mohammadreza Chimerad, Sasan Asiaei, Mahdi Navidbakhsh, and Aman Russom. "Frequency dependent multiphase flows on centrifugal microfluidics." Lab on a Chip 20, no. 3 (2020): 514–24. http://dx.doi.org/10.1039/c9lc00924h.

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10

Noroozi, Zahra, Horacio Kido, Miodrag Micic, Hansheng Pan, Christian Bartolome, Marko Princevac, Jim Zoval, and Marc Madou. "Reciprocating flow-based centrifugal microfluidics mixer." Review of Scientific Instruments 80, no. 7 (July 2009): 075102. http://dx.doi.org/10.1063/1.3169508.

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11

Peshin, Snehan, Marc Madou, and Lawrence Kulinsky. "Microvalves for Applications in Centrifugal Microfluidics." Sensors 22, no. 22 (November 18, 2022): 8955. http://dx.doi.org/10.3390/s22228955.

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Centrifugal microfluidic platforms (CDs) have opened new possibilities for inexpensive point-of-care (POC) diagnostics. They are now widely used in applications requiring polymerase chain reaction steps, blood plasma separation, serial dilutions, and many other diagnostic processes. CD microfluidic devices allow a variety of complex processes to transfer onto the small disc platform that previously were carried out by individual expensive laboratory equipment requiring trained personnel. The portability, ease of operation, integration, and robustness of the CD fluidic platforms requires simple, reliable, and scalable designs to control the flow of fluids. Valves play a vital role in opening/closing of microfluidic channels to enable a precise control of the flow of fluids on a centrifugal platform. Valving systems are also critical in isolating chambers from the rest of a fluidic network at required times, in effectively directing the reagents to the target location, in serial dilutions, and in integration of multiple other processes on a single CD. In this paper, we review the various available fluidic valving systems, discuss their working principles, and evaluate their compatibility with CD fluidic platforms. We categorize the presented valving systems into either “active”, “passive”, or “hybrid”—based on their actuation mechanism that can be mechanical, thermal, hydrophobic/hydrophilic, solubility-based, phase-change, and others. Important topics such as their actuation mechanism, governing physics, variability of performance, necessary disc spin rate for valve actuation, valve response time, and other parameters are discussed. The applicability of some types of valves for specialized functions such as reagent storage, flow control, and other applications is summarized.

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12

Acharya, Sourav, Jasleen Chhabra, Soumyo Mukherji, and Debjani Paul. "A low-cost and portable centrifugal microfluidic platform for continuous processing of large sample volumes." AIP Advances 13, no. 1 (January 1, 2023): 015212. http://dx.doi.org/10.1063/5.0128239.

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Centrifugal microfluidic platforms are becoming increasing popular in many research and diagnostic applications. A major challenge in centrifugal microfluidics is continuous handling of large sample volumes. Keeping the flow rate constant during sample inflow is difficult without a pump. We report an affordable (<USD 40) and portable platform that can handle sample volumes of up to 50 ml without a pump. We use a Mariotte bottle for sample inflow into the disk at a constant flow rate and with a throughput of 1 ml/s. Our pumping mechanism allows basic operations, such as volume metering, flow switching, and mixing. Our platform fulfills the need for portable and affordable instrumentation in developing countries.

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13

Klatt, J. N., M. Depke, N. Goswami, N. Paust, R. Zengerle, F. Schmidt, and T. Hutzenlaub. "Tryptic digestion of human serum for proteomic mass spectrometry automated by centrifugal microfluidics." Lab on a Chip 20, no. 16 (2020): 2937–46. http://dx.doi.org/10.1039/d0lc00530d.

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14

Shih, Chih Hsin, Chien Hsing Lu, Chia Hui Lin, and Hou Jin Wu. "Design and Analysis of Micromixers on a Centrifugal Platform." Advanced Materials Research 74 (June 2009): 203–6. http://dx.doi.org/10.4028/www.scientific.net/amr.74.203.

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This work reports a novel mixing design that can do fast, batch-typed liquid mixing on a centrifugal platform. Mixing is an important procedure for many applications related to chemical reactors and biological assays, especially in the field of microfluidics. The extremely small sizes of microchannels make it difficult to achieve turbulence to assist mixing. To overcome this problem, a meandering fluidic design on the centrifugal platform is proposed. Centrifual force promotes mixing by inducing lateral flow movement in the circular section and flow focusing effect in the bending section. The degree of mixing was studied for solutions with various viscosities under different rotational speeds. The experimental results showed that this mixer can mix microliter or nanoliter volumes of aqueous solutions within one second.

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15

Liu, Xun, Yuan Ji, Yongbo Deng, and Yihui Wu. "Advection of droplet collision in centrifugal microfluidics." Physics of Fluids 31, no. 3 (March 2019): 032003. http://dx.doi.org/10.1063/1.5082218.

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16

Hess, J. F., S. Zehnle, P. Juelg, T. Hutzenlaub, R. Zengerle, and N. Paust. "Review on pneumatic operations in centrifugal microfluidics." Lab on a Chip 19, no. 22 (2019): 3745–70. http://dx.doi.org/10.1039/c9lc00441f.

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The combination of pneumatic and centrifugal forces enables robust automation of multistep biochemical workflows. We review technical implementations on microfluidic cartridges and discuss the design of pneumatic unit operations within two tutorials.

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17

Maguire, I., R. O'Kennedy, J. Ducrée, and F. Regan. "A review of centrifugal microfluidics in environmental monitoring." Analytical Methods 10, no. 13 (2018): 1497–515. http://dx.doi.org/10.1039/c8ay00361k.

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18

Boisen, Anja. "(Sensor Division Outstanding Achievement Award) Micro/Nano Sensors and Drug Delivery." ECS Meeting Abstracts MA2022-02, no. 61 (October 9, 2022): 2247. http://dx.doi.org/10.1149/ma2022-02612247mtgabs.

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Our research center of excellence ‘IDUN’ combines research in nanosensors/centrifugal microfluidics and microfabricated devices for oral drug delivery. This allows us to explore the synergy between sensor development and search for new pharmaceutical delivery tools and materials. I will show examples of recent findings and results within drug/polymer characterization, microdevices for drug delivery and diagnostics. Also, new applications within therapeutic drug monitoring using Surface Enhanced Raman Scattering will be presented as well as sensor integration with centrifugal microfluidics platforms. In the future our vision is to combine sensing and delivery, to be able to perform e.g. personalized medication.

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19

Azimi-Boulali, Javid, Masoud Madadelahi, Marc J. Madou, and Sergio O. Martinez-Chapa. "Droplet and Particle Generation on Centrifugal Microfluidic Platforms: A Review." Micromachines 11, no. 6 (June 22, 2020): 603. http://dx.doi.org/10.3390/mi11060603.

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The use of multiphase flows in microfluidics to carry dispersed phase material (droplets, particles, bubbles, or fibers) has many applications. In this review paper, we focus on such flows on centrifugal microfluidic platforms and present different methods of dispersed phase material generation. These methods are classified into three specific categories, i.e., step emulsification, crossflow, and dispenser nozzle. Previous works on these topics are discussed and related parameters and specifications, including the size, material, production rate, and rotational speed are explicitly mentioned. In addition, the associated theories and important dimensionless numbers are presented. Finally, we discuss the commercialization of these devices and show a comparison to unveil the pros and cons of the different methods so that researchers can select the centrifugal droplet/particle generation method which better suits their needs.

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20

Wang, Guanghui, Jie Tan, Minghui Tang, Changbin Zhang, Dongying Zhang, Wenbin Ji, Junhao Chen, Ho-Pui Ho, and Xuping Zhang. "Binary centrifugal microfluidics enabling novel, digital addressable functions for valving and routing." Lab on a Chip 18, no. 8 (2018): 1197–206. http://dx.doi.org/10.1039/c8lc00026c.

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21

Schaff, Ulrich Y., and Greg J. Sommer. "Whole Blood Immunoassay Based on Centrifugal Bead Sedimentation." Clinical Chemistry 57, no. 5 (May 1, 2011): 753–61. http://dx.doi.org/10.1373/clinchem.2011.162206.

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BACKGROUND Centrifugal “lab on a disk” microfluidics is a promising avenue for developing portable, low-cost, automated immunoassays. However, the necessity of incorporating multiple wash steps results in complicated designs that increase the time and sample/reagent volumes needed to run assays and raises the probability of errors. We present proof of principle for a disk-based microfluidic immunoassay technique that processes blood samples without conventional wash steps. METHODS Microfluidic disks were fabricated from layers of patterned, double-sided tape and polymer sheets. Sample was mixed on-disk with assay capture beads and labeling antibodies. Following incubation, the assay beads were physically separated from the blood cells, plasma, and unbound label by centrifugation through a density medium. A signal-laden pellet formed at the periphery of the disk was analyzed to quantify concentration of the target analyte. RESULTS To demonstrate this technique, the inflammation biomarkers C-reactive protein and interleukin-6 were measured from spiked mouse plasma and human whole blood samples. On-disk processing (mixing, labeling, and separation) facilitated direct assays on 1-μL samples with a 15-min sample-to-answer time, <100 pmol/L limit of detection, and 10% CV. We also used a unique single-channel multiplexing technique based on the sedimentation rate of different size or density bead populations. CONCLUSIONS This portable microfluidic system is a promising method for rapid, inexpensive, and automated detection of multiple analytes directly from a drop of blood in a point-of-care setting.

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22

Li, Qi, Xingchen Zhou, Qian Wang, Wenfang Liu, and Chuanpin Chen. "Microfluidics for COVID-19: From Current Work to Future Perspective." Biosensors 13, no. 2 (January 20, 2023): 163. http://dx.doi.org/10.3390/bios13020163.

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Spread of coronavirus disease 2019 (COVID-19) has significantly impacted the public health and economic sectors. It is urgently necessary to develop rapid, convenient, and cost-effective point-of-care testing (POCT) technologies for the early diagnosis and control of the plague’s transmission. Developing POCT methods and related devices is critical for achieving point-of-care diagnosis. With the advantages of miniaturization, high throughput, small sample requirements, and low actual consumption, microfluidics is an essential technology for the development of POCT devices. In this review, according to the different driving forces of the fluid, we introduce the common POCT devices based on microfluidic technology on the market, including paper-based microfluidic, centrifugal microfluidic, optical fluid, and digital microfluidic platforms. Furthermore, various microfluidic-based assays for diagnosing COVID-19 are summarized, including immunoassays, such as ELISA, and molecular assays, such as PCR. Finally, the challenges of and future perspectives on microfluidic device design and development are presented. The ultimate goals of this paper are to provide new insights and directions for the development of microfluidic diagnostics while expecting to contribute to the control of COVID-19.

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23

Burger, S., M. Schulz, F. von Stetten, R. Zengerle, and N. Paust. "Rigorous buoyancy driven bubble mixing for centrifugal microfluidics." Lab on a Chip 16, no. 2 (2016): 261–68. http://dx.doi.org/10.1039/c5lc01280e.

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24

Okamoto, Shunya, and Yoshiaki Ukita. "Automatic microfluidic enzyme-linked immunosorbent assay based on CLOCK-controlled autonomous centrifugal microfluidics." Sensors and Actuators B: Chemical 261 (May 2018): 264–70. http://dx.doi.org/10.1016/j.snb.2018.01.150.

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25

Ding, Zhaoxiong, Dongying Zhang, Guanghui Wang, Minghui Tang, Yumin Dong, Yixin Zhang, Ho-pui Ho, and Xuping Zhang. "An in-line spectrophotometer on a centrifugal microfluidic platform for real-time protein determination and calibration." Lab on a Chip 16, no. 18 (2016): 3604–14. http://dx.doi.org/10.1039/c6lc00542j.

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26

Brenner, Thilo, Thomas Glatzel, Roland Zengerle, and Jens Ducrée. "Frequency-dependent transversal flow control in centrifugal microfluidics." Lab Chip 5, no. 2 (2005): 146–50. http://dx.doi.org/10.1039/b406699e.

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27

Peytavi, Régis, Frédéric R. Raymond, Dominic Gagné, François J. Picard, Guangyao Jia, Jim Zoval, Marc Madou, et al. "Microfluidic Device for Rapid (<15 min) Automated Microarray Hybridization." Clinical Chemistry 51, no. 10 (October 1, 2005): 1836–44. http://dx.doi.org/10.1373/clinchem.2005.052845.

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Abstract Background: Current hybridization protocols on microarrays are slow and need skilled personnel. Microfluidics is an emerging science that enables the processing of minute volumes of liquids to perform chemical, biochemical, or enzymatic analyzes. The merging of microfluidics and microarray technologies constitutes an elegant solution that will automate and speed up microarray hybridization. Methods: We developed a microfluidic flow cell consisting of a network of chambers and channels molded into a polydimethylsiloxane substrate. The substrate was aligned and reversibly bound to the microarray printed on a standard glass slide to form a functional microfluidic unit. The microfluidic units were placed on an engraved, disc-shaped support fixed on a rotational device. Centrifugal forces drove the sample and buffers directly onto the microarray surface. Results: This microfluidic system increased the hybridization signal by ∼10fold compared with a passive system that made use of 10 times more sample. By means of a 15–min automated hybridization process, performed at room temperature, we demonstrated the discrimination of 4 clinically relevant Staphylococcus species that differ by as little as a single-nucleotide polymorphism. This process included hybridization, washing, rinsing, and drying steps and did not require any purification of target nucleic acids. This platform was sensitive enough to detect 10 PCR-amplified bacterial genomes. Conclusion: This removable microfluidic system for performing microarray hybridization on glass slides is promising for molecular diagnostics and gene profiling.

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28

Ge, Ya-Hao, Yi-Mei Lan, Xing-Rui Li, Yu-Wei Shan, Yu-Jie Yang, Sen-Sen Li, Chaoyong Yang, and Lu-Jian Chen. "Polymerized cholesteric liquid crystal microdisks generated by centrifugal microfluidics towards tunable laser emissions [Invited]." Chinese Optics Letters 18, no. 8 (2020): 080006. http://dx.doi.org/10.3788/col202018.080006.

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29

Kainz, Daniel M., Susanna M. Früh, Tobias Hutzenlaub, Roland Zengerle, and Nils Paust. "Flow control for lateral flow strips with centrifugal microfluidics." Lab on a Chip 19, no. 16 (2019): 2718–27. http://dx.doi.org/10.1039/c9lc00308h.

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Lateral flow strips (LFSs) are widely used for clinical diagnostics. The restricted flow control is one challenge to the development of quantitative and highly sensitive LFSs. Here, we present a flow control for LFSs using centrifugal microfluidics.

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30

Miyazaki, Celina M., Eadaoin Carthy, and David J. Kinahan. "Biosensing on the Centrifugal Microfluidic Lab-on-a-Disc Platform." Processes 8, no. 11 (October 28, 2020): 1360. http://dx.doi.org/10.3390/pr8111360.

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Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use. The present global pandemic draws attention to the importance of rapid sample-to-answer PoC devices for minimising manual intervention and sample manipulation, thus increasing the safety of the health professional while minimising the chances of sample contamination. A biosensor is defined by its ability to measure an analyte by converting a biological binding event to tangible analytical data. With evolving manufacturing processes for both LoaDs and biosensors, it is becoming more feasible to embed biosensors within the platform and/or to pair the microfluidic cartridges with low-cost detection systems. This review considers the basics of the centrifugal microfluidics and describes recent developments in common biosensing methods and novel technologies for fluidic control and automation. Finally, an overview of current devices on the market is provided. This review will guide scientists who want to initiate research in LoaD PoC devices as well as providing valuable reference material to researchers active in the field.

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31

Kazemzadeh, Amin, P. Ganesan, Fatimah Ibrahim, Lawrence Kulinsky, and Marc J. Madou. "Guided routing on spinning microfluidic platforms." RSC Advances 5, no. 12 (2015): 8669–79. http://dx.doi.org/10.1039/c4ra14397c.

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A robust two stage passive microvalve is devised that can be used for (a) changing the flow direction continuously from one direction to another, and (b) liquid/particle distribution in centrifugal microfluidics.

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32

Delgado, Saraí M. Torres, David J. Kinahan, Fralett Suárez Sandoval, Lourdes Albina Nirupa Julius, Niamh A. Kilcawley, Jens Ducrée, and Dario Mager. "Fully automated chemiluminescence detection using an electrified-Lab-on-a-Disc (eLoaD) platform." Lab on a Chip 16, no. 20 (2016): 4002–11. http://dx.doi.org/10.1039/c6lc00973e.

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33

Hin, S., N. Paust, M. Keller, M. Rombach, O. Strohmeier, R. Zengerle, and K. Mitsakakis. "Temperature change rate actuated bubble mixing for homogeneous rehydration of dry pre-stored reagents in centrifugal microfluidics." Lab on a Chip 18, no. 2 (2018): 362–70. http://dx.doi.org/10.1039/c7lc01249g.

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Temperature change rate as actuation principle for a bubble mixer in centrifugal microfluidics minimizes external means required. We applied the new bubble mixer to the rehydration of dry reagents for nucleic acid amplification.

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34

Woolf, Michael, Leah Dignan, Scott Karas, Hannah Lewis, Kevyn Hadley, Aeren Nauman, Marcellene Gates-Hollingsworth, et al. "Characterization of a Centrifugal Microfluidic Orthogonal Flow Platform." Micromachines 13, no. 3 (March 20, 2022): 487. http://dx.doi.org/10.3390/mi13030487.

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To bring to bear the power of centrifugal microfluidics on vertical flow immunoassays, control of flow orthogonally through nanoporous membranes is essential. The on-disc approach described here leverages the rapid print-cut-laminate (PCL) disc fabrication and prototyping method to create a permanent seal between disc materials and embedded nanoporous membranes. Rotational forces drive fluid flow, replacing capillary action, and complex pneumatic pumping systems. Adjacent microfluidic features form a flow path that directs fluid orthogonally (vertically) through these embedded membranes during assay execution. This method for membrane incorporation circumvents the need for solvents (e.g., acetone) to create the membrane-disc bond and sidesteps issues related to undesirable bypass flow. In other recently published work, we described an orthogonal flow (OF) platform that exploited embedded membranes for automation of enzyme-linked immunosorbent assays (ELISAs). Here, we more fully characterize flow patterns and cellulosic membrane behavior within the centrifugal orthogonal flow (cOF) format. Specifically, high-speed videography studies demonstrate that sample volume, membrane pore size, and ionic composition of the sample matrix significantly impact membrane behavior, and consequently fluid drainage profiles, especially when cellulosic membranes are used. Finally, prototype discs are used to demonstrate proof-of-principle for sandwich-type antigen capture and immunodetection within the cOF system.

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35

Noroozi, Zahra, Horacio Kido, Régis Peytavi, Rie Nakajima-Sasaki, Algimantas Jasinskas, Miodrag Micic, Philip L. Felgner, and Marc J. Madou. "A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics." Review of Scientific Instruments 82, no. 6 (June 2011): 064303. http://dx.doi.org/10.1063/1.3597578.

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36

Yeo, Joo Chuan, Kenry, Zhihai Zhao, Pan Zhang, Zhiping Wang, and Chwee Teck Lim. "Label-free extraction of extracellular vesicles using centrifugal microfluidics." Biomicrofluidics 12, no. 2 (March 2018): 024103. http://dx.doi.org/10.1063/1.5019983.

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37

Yu, Zeta Tak For, Jophin George Joseph, Shirley Xiaosu Liu, Mei Ki Cheung, Parker James Haffey, Katsuo Kurabayashi, and Jianping Fu. "Centrifugal microfluidics for sorting immune cells from whole blood." Sensors and Actuators B: Chemical 245 (June 2017): 1050–61. http://dx.doi.org/10.1016/j.snb.2017.01.113.

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38

Grumann, Markus, Thilo Brenner, Christian Beer, Roland Zengerle, and Jens Ducrée. "Visualization of flow patterning in high-speed centrifugal microfluidics." Review of Scientific Instruments 76, no. 2 (February 2005): 025101. http://dx.doi.org/10.1063/1.1834703.

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39

CHEN, Jerry Min, Yu-Jen CHEN, and Lung-Sheng TSENG. "Micromixing of Fluids within Droplets Generated on Centrifugal Microfluidics." Journal of Fluid Science and Technology 8, no. 2 (2013): 200–208. http://dx.doi.org/10.1299/jfst.8.200.

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40

Keller, M., G. Czilwik, J. Schott, I. Schwarz, K. Dormanns, F. von Stetten, R. Zengerle, and N. Paust. "Robust temperature change rate actuated valving and switching for highly integrated centrifugal microfluidics." Lab on a Chip 17, no. 5 (2017): 864–75. http://dx.doi.org/10.1039/c6lc01536k.

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Thermally induced underpressure for temperature change rate (TCR) actuated siphon valving, which is controlled by the rotational frequency. The TCR actuated siphon valve makes use of already present air vents for implementation at no additional cost in centrifugal microfluidics.

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41

Klatt, J. N., T. J. Dinh, O. Schilling, R. Zengerle, F. Schmidt, T. Hutzenlaub, and N. Paust. "Automation of peptide desalting for proteomic liquid chromatography – tandem mass spectrometry by centrifugal microfluidics." Lab on a Chip 21, no. 11 (2021): 2255–64. http://dx.doi.org/10.1039/d1lc00137j.

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Andreasen, Sune Z., Dorota Kwasny, Letizia Amato, Anna Line Brøgger, Filippo G. Bosco, Karsten B. Andersen, Winnie E. Svendsen, and Anja Boisen. "Integrating electrochemical detection with centrifugal microfluidics for real-time and fully automated sample testing." RSC Advances 5, no. 22 (2015): 17187–93. http://dx.doi.org/10.1039/c4ra16858e.

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Snider, Adam, Ileana Pirozzi, and Anubhav Tripathi. "Centrifugal Microfluidics Traps for Parallel Isolation and Imaging of Single Cells." Micromachines 11, no. 2 (January 29, 2020): 149. http://dx.doi.org/10.3390/mi11020149.

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Analysis at the single cell level has becoming an increasingly important procedure to diagnose cancer tissue biopsies. These tissue samples are often heterogeneous and consist of 1000–15,000 cells. We study the use of centrifugal microfluidics to isolate single cells into micro chambers. We describe the optimization of our microfluidics flow device, characterize its performance using both polystyrene beads as a cell analogue and MCF-7 breast cancer cells, and discuss potential applications for the device. Our results show rapid isolation of ~2000 single cell aliquots in ~20 min. We were able to occupy 65% of available chambers with singly occupied cancer cells, and observed capture efficiencies as high as 80% using input samples ranging from 2000 to 15,000 cells in 20 min. We believe our device is a valuable research tool that addresses the unmet need for massively parallel single cell level analysis of cell populations.

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Schwemmer, F., T. Hutzenlaub, D. Buselmeier, N. Paust, F. von Stetten, D. Mark, R. Zengerle, and D. Kosse. "Centrifugo-pneumatic multi-liquid aliquoting – parallel aliquoting and combination of multiple liquids in centrifugal microfluidics." Lab on a Chip 15, no. 15 (2015): 3250–58. http://dx.doi.org/10.1039/c5lc00513b.

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Mahmodi Arjmand, Ehsan, Maryam Saadatmand, Manouchehr Eghbal, Mohammad Reza Bakhtiari, and Sima Mehraji. "A New Detection Chamber Design on Centrifugal Microfluidic Platform to Measure Hemoglobin of Whole Blood." SLAS TECHNOLOGY: Translating Life Sciences Innovation 26, no. 4 (March 1, 2021): 392–98. http://dx.doi.org/10.1177/2472630320985456.

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Undoubtedly, microfluidics has been a focal point of interdisciplinary science during the last two decades, resulting in many developments in this area. Centrifugal microfluidic platforms have good potential for use in point-of-care devices because they take advantage of some intrinsic forces, most notably centrifugal force, which obviates the need to any external driving forces. Herein, we introduce a newly designed detection chamber for use on microfluidic discs that can be employed as an absorbance readout step in cases where the final solution has a very low viscosity and surface tension. In such situations, our chamber easily eliminates the air bubbles from the final solution without any interruption. One microfluidic disc for measuring the hemoglobin concentration was designed and constructed to verify the correct functioning of this detection chamber. This disc measured the hemoglobin concentration of the blood samples via the HiCN method. Then, the hemoglobin concentration of 11 blood samples was quantified and compared with the clinic’s data using the hemoglobin measurement disc, which included four hemoglobin measurement sets, and each set contained two inlets for the blood sample and the reagent, one two-part mixing chamber, and one bubble-free detection chamber. The measured values of the disc had good linearity and conformity compared with the clinic’s data, and there were no air bubbles in the detection step. In this study, the standard deviation and the turnaround time were ± 0.51 g/dL and 68 s, respectively.

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Madadelahi, Masoud, Javid Azimi-Boulali, Marc Madou, and Sergio Omar Martinez-Chapa. "Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics." Micromachines 13, no. 6 (May 31, 2022): 881. http://dx.doi.org/10.3390/mi13060881.

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The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets.

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Xiao, Yujin, Shunji Li, Zheng Pang, Chao Wan, Lina Li, Huijuan Yuan, Xianzhe Hong, et al. "Multi-reagents dispensing centrifugal microfluidics for point-of-care testing." Biosensors and Bioelectronics 206 (June 2022): 114130. http://dx.doi.org/10.1016/j.bios.2022.114130.

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Hess, Jacob Friedrich, Maria Elena Hess, Roland Zengerle, Nils Paust, Melanie Boerries, and Tobias Hutzenlaub. "Automated library preparation for whole genome sequencing by centrifugal microfluidics." Analytica Chimica Acta 1182 (October 2021): 338954. http://dx.doi.org/10.1016/j.aca.2021.338954.

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Klatt, Jan-Niklas, Ingmar Schwarz, Tobias Hutzenlaub, Roland Zengerle, Frank Schwemmer, Dominique Kosse, Jake Vincent, et al. "Miniaturization, Parallelization, and Automation of Endotoxin Detection by Centrifugal Microfluidics." Analytical Chemistry 93, no. 24 (June 8, 2021): 8508–16. http://dx.doi.org/10.1021/acs.analchem.1c01041.

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Peshin, Snehan, Derosh George, Roya Shiri, and Marc Madou. "Reusable Capillary Flow-Based Wax Switch Valve for Centrifugal Microfluidics." ECS Meeting Abstracts MA2021-01, no. 60 (May 30, 2021): 1611. http://dx.doi.org/10.1149/ma2021-01601611mtgabs.

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