Journal articles: 'Centre of Advanced Study in Sanskrit'

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Smith, John D. "S. D. Joshi and Saroja Bhate: The fundamentals of anuvṛtti. (Publications of the Centre of Advanced Study in Sanskrit, Class B, No. 9.) viii, 350 pp. Pune: University of Poona, 1984 - S. D. Joshi and S. D. Laddu (ed.): proceedings of the International Seminar on Studies in the Aṣṭādhyāyī of Pāṇini. (Publications of the Center of Advanced Study in Sanskrit, Class e, No. 9.) xxiii, 232 pp. Pune: University of Poona, 1983." Bulletin of the School of Oriental and African Studies 49, no. 2 (June 1986): 401–2. http://dx.doi.org/10.1017/s0041977x0002440x.

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Kumar, Sonu, Shivam Gupta, Sandeep Singh, and Nidheesh Yadav. "Kinetics of Kapalbhati: A mathematical interpretation of force, pressure, centre of gravity and centre of mass." International Journal of Scientific & Engineering Research 13, no. 10 (November 25, 2022): 181–88. http://dx.doi.org/10.14299/ijser.2022.11.01.

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This article introduces the theoretical study of kinetics of kapalbhati, how mathematical parameters correlated to each other. Kapalbhati is high frequency yoga breathing (exhalation breathing rate up to 2 Hz) literally means shining forehead (kapala = cranium or forehead, bhati = shining or even knowledge in Sanskrit). It is known widely for its positive effects on abdominal muscles and overall health. Kapalbhati plays an important role to enhance the abdominal muscle strength and its muscle tone as well.

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Kakkar, Shruti. "NATURE OF AESTHETIC CLASSICAL THINKING IN SECULAR SANSKRIT LITERATURE." International Journal of Research -GRANTHAALAYAH 7, no. 11 (November 30, 2019): 268–73. http://dx.doi.org/10.29121/granthaalayah.v7.i11.2019.3751.

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English: The Ramayana and the Mahabharata are considered epics, which are two representative texts of the advanced tradition of Indian literature. Their study gives the knowledge of the state of art prevailing at that time. By the time of "Ramayana" and "Mahabharata", there had been substantial development of painting, sculpture and architecture. Hindi: रामायण और महाभारत को महाकाव्य माना जाता है जो भारतीय साहित्य की उन्नत परम्परा के दो प्रतिनिधि ग्रन्थ हैं। इनके अध्ययन से उस समय प्रचलित कला की स्थिति का ज्ञान होता है। ''रामायण'' और ''महाभारत'' काल तक चित्रकला, मूर्तिकला व वास्तुकला का पर्याप्त विकास हो चुका था।

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Woolf, Stuart. "The Centre for the Advanced Study of Italian Society at Reading." Modern Italy 16, no. 4 (November 2011): 473–78. http://dx.doi.org/10.1080/13532944.2011.611232.

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The Centre for the Advanced Study of Italian Society was created by Stuart Woolf at Reading University in 1966. It provided the institutional basis for close collaboration with Italian academics and politicians, many of whom participated in seminars. It attracted funding from Italy for research collaboration with Italian academics. The presence of the Centre led to donations from English antifascists of books and archives, and to the acquisition by the University Library of a major Italian private library on post-unity Italian history and culture.

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Mushi, Grace Leonard, Furaha Serventi, Julius Pius Alloyce, Vivian Frank Saria, Xianghua Xu, Khalid Khan, Qinqin Cheng, and Yongyi Chen. "Willingness of advanced cancer patients to receive palliative care and its determinants: A cross-sectional study in Northern Tanzania." PLOS ONE 18, no. 10 (October 5, 2023): e0290377. http://dx.doi.org/10.1371/journal.pone.0290377.

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Background The purpose of this study was to assess willingness of advanced cancer patients to receive palliative care and its determinants at Cancer Care Centre in Kilimanjaro Christian Medical Centre Northern Tanzania. Objective The purpose of this study was to assess willingness of advanced cancer patients to receive palliative care and its determinants at Cancer Care Centre in Kilimanjaro Christian Medical Centre Northern Tanzania. Methods This was an institution-based cross-sectional study and the target population was all advanced cancer patients attending care at Cancer care Centre in Northern Tanzania. Data was collected using a structured questionnaire and analysed using Stata for windows 15. A descriptive analysis was conducted to summarize the data using mean standard deviation, while categorical data was summarized using frequency and percentages. Both bivariate and multivariate logistic regression analysis was used to determine the predictors associated with willingness to receive palliative care. Results The results showed that more than half of the respondents had willingness to accept palliative care. The degree of willingness PC among advanced cancer patients was high 60.6% (95%CI: 55.8–65.3). The predictors which remained significant associated with willingness to receive palliative care in multivariate analysis were the knowledgeable of palliative care [AOR: 2.86; 95%CI: 1.69–4.85] and high perceived benefits of palliative care [AOR: 3.58; 95%CI: 2.12–6.04]. Conclusion Willingness to accept palliative care services was more than half of the patients just 60.6% among patients with advanced cancer from the study site. Advanced age of a patient, occupations, better knowledge, and perceived benefits for palliative care was the significant predictor for patients’ willingness to accept palliative care.

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Umrethwala, Sakina Muslim, Sohel Shaikh, Tushar Tatyabe Palve, Komal Devnikar, and Sejal Kulkarni. "Outcome of advanced epithelial ovarian cancer: a tertiary care centre study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 6 (May 26, 2023): 1644–49. http://dx.doi.org/10.18203/2320-1770.ijrcog20231529.

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Background: Ovarian cancer is the fourth most common cancer in Indian women with an incidence of 4.9 cases per 100,000. Epithelial ovarian cancer is a silent killer disease as it presents at an advanced stage with minimal signs and symptoms. Methods: It is a type of research article. The present study was conducted in Department of Obstetrics and Gynecology, Cama and Albless Hospital, Mumbai, Maharashtra, India, from a period of January 2018 to July 2019, during which 53 cases of EOC were studied. Results: Out of 53 cases of EOC, 45 cases were advanced stage EOC, they were either operated as PDS-ACT or NACT- IDS. Conclusions: NACT is recommended wherein optimal cytoreduction appears unlikely, or in patients where upfront surgery is high risk and extensive causing high morbidity post-surgery. Places where there is non-availability of special surgical expertise and hospital resources, there too NACT-IDS is recommended.

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P.N., Wichendu, and Dodiyi-Manuel A. "Advanced Breast Cancer in Nigeria: A Single Centre Experience." African Journal of Biology and Medical Research 4, no. 2 (May 17, 2021): 51–56. http://dx.doi.org/10.52589/ajbmr-t1cpaeni.

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Background: Breast cancer is the most common cancer globally and in Nigeria, it constitutes about 12% of all new cancers and 25% of all cancers in women. In Nigeria, the majority of patients present with late disease and globally, advanced breast cancer is associated with a low survival rate among patients. This study seeks to review the presentation of advanced breast cancer as seen in the University of Port Harcourt Teaching Hospital, Southern Nigeria. Patients and Methods: This is a 5-year retrospective study conducted at the University of Port Harcourt Teaching Hospital. Records of patients that presented to the hospital within the study period with histologically proven breast cancer (stages 3 and 4) were retrieved, and relevant data extracted and analysed using SPSS version 22. Results: There were 47 patients with advanced breast cancer and they were all females. Their ages ranged from 25 to 72 years with a mean of 43.9 ± 4.7 and peak age of 31–50 years. Majority of the patients (72.3%) had stage 3 disease while 13 (27.7%) of them had stage 4. The lung was the commonest metastatic site and this was seen in 7 (14.9%) patients, followed by the liver in 1 (2.1%). Conclusion: Advanced breast cancer remains a dreaded disease that reduces patients’ quality of life significantly and may also be rapidly fatal. Community-based efforts in collaboration with Non-Governmental Organizations (NGOs) targeted at information dissemination to the public, and offering breast cancer screening and subsidized cancer treatment are essential to reduce the mortality associated with this deadly disease.

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Singhal, Aaditi. "Sanskrit Scriptures (Ancient Indian History) and Their Scientific Relevance in Modern Science." International Journal for Research in Applied Science and Engineering Technology 11, no. 12 (December 31, 2023): 2185–93. http://dx.doi.org/10.22214/ijraset.2023.57820.

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Abstract: Ancient Indian Science has a plethora of knowledge which include Vedas, Upanishads, Bhagavad Gita, and Puranas but limited online resources available to everyone. to Indian Ancient History preserves the truths of modern science and many justifications of present questions raised in the field of sciences. Most of these scriptures were written in 500-1500 BCE, an era which is believed to have lacked scientific knowledge and reasonings. Many of the Indian transcripts testify data and proofs evident in the Ancient Indian Literature. The Vedas contain intricate details about celestial bodies, their movements, and the concept of time, reflecting an advanced understanding of astronomy. Mathematical concepts, including geometry and algebraic principles, are discernible in texts like the Shulba Sutras. Moreover, Ayurveda, an ancient Indian medical system documented in Sanskrit, provides holistic insights into healthcare, emphasizing a balance of physical, mental, and spiritual well-being. The scriptures also exhibit ecological awareness, prescribing sustainable practices for harmonious coexistence with nature. Sushruta Samhita and other scriptures provide in depth details of utilization of every plant part for cure of diseases. This study encompasses reasonings and specific citing of exact verses of scientific findings found years before modern scientists. Further research will contribute in expansion of knowledge and help delve deeper into Ancient Indian Text.

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Alam, Mohammed Iftekharul, Kiran Natarajan, Takhellambam Biram Singh, Abha Kumari, and Mohan Kameswaran. "Management of advanced otosclerosis: experience in a tertiary care centre." International Journal of Otorhinolaryngology and Head and Neck Surgery 4, no. 2 (February 23, 2018): 376. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20180439.

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Background: Advanced otosclerosis affects approximately 10% of patients with otosclerosis. Ossification of the cochlea increases with the course of the disease and may cause sensori-neural or mixed hearing loss. Hearing aids, stapedotomy and cochlear implants are management options for hearing loss associated with advanced otosclerosis. Methods: A retrospective study of 153 patients with advanced otosclerosis was done in a tertiary ENT centre. 110 patients with advanced otosclerosis underwent stapedotomy and 43 patients with advanced otosclerosis underwent cochlear implantation (CI) from 1997 till date. Exclusion criteria included patients with profound hearing loss from causes other than otosclerosis. The aim was to study the indications, selection criteria, as well as surgical issues of stapedotomy and cochlear implantation in patients with advanced otosclerosis. Results: Stapedotomy followed by use of hearing aid was found to give good outcomes in advanced otosclerosis. Patients with advanced otosclerosis who had poor pre-operative speech discrimination underwent CI. Complete insertion was possible in 39 patients and partial insertion was done in 4 patients. The outcomes of cochlear implantation were found to be satisfactory. Facial nerve stimulation was seen in 5 patients who underwent CI; however this was successfully managed by reprogramming or switching off the concerned electrodes. Conclusions: In our experience, stapedotomy or CI in advanced otosclerosis has proven successful, with a low complication rate. The selection criteria for stapedotomy versus CI have to be stringent for optimal outcomes.

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Rombouts, SJ, TH Mungroop, MN Heilmann, HW van Laarhoven, OR Busch, IQ Molenaar, MG Besselink, and JW Wilmink. "FOLFIRINOX in Locally Advanced and Metastatic Pancreatic Cancer: A Single Centre Cohort Study." Journal of Cancer 7, no. 13 (2016): 1861–66. http://dx.doi.org/10.7150/jca.16279.

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Huis in 't Veld, E. A., D. J. Grünhagen, C. Verhoef, H. G. Smith, A. C. J. van Akkooi, R. Jones, F. van Coevorden, A. J. Hayes, and W. J. van Houdt. "Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study." European Journal of Cancer 85 (November 2017): 114–21. http://dx.doi.org/10.1016/j.ejca.2017.07.023.

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Piña-Fuentes, Dan, Martijn Beudel, Simon Little, Peter Brown, D. L. Marinus Oterdoom, and J. Marc C. van Dijk. "Adaptive deep brain stimulation as advanced Parkinson’s disease treatment (ADAPT study): protocol for a pseudo-randomised clinical study." BMJ Open 9, no. 6 (June 2019): e029652. http://dx.doi.org/10.1136/bmjopen-2019-029652.

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IntroductionAdaptive deep brain stimulation (aDBS), based on the detection of increased beta oscillations in the subthalamic nucleus (STN), has been assessed in patients with Parkinson’s disease (PD) during the immediate postoperative setting. In these studies, aDBS was shown to be at least as effective as conventional DBS (cDBS), while stimulation time and side effects were reduced. However, the effect of aDBS on motor symptoms and stimulation-induced side effects during the chronically implanted phase (after the stun effect of DBS placement has disappeared) has not yet been determined.Methods and analysisThis protocol describes a single-centre clinical study in which aDBS will be tested in 12 patients with PD undergoing battery replacement, with electrodes implanted in the STN, and as a proof of concept in the internal globus pallidus. Patients included will be allocated in a pseudo-randomised fashion to a three-condition (no stimulation/cDBS/ aDBS), cross-over design. A battery of tests will be conducted and recorded during each condition, which aim to measure the severity of motor symptoms and side effects. These tests include a tablet-based tapping test, a subscale of the Movement Disorder Society-unified Parkinson’s disease rating scale (subMDS-UPDRS), the Speech Intelligibility Test (SIT) and a tablet-based version of the Stroop test. SubMDS-UPDRS and SIT recordings will be blindly assessed by independent raters. Data will be analysed using a linear mixed-effects model.Ethics and disseminationThis protocol was approved by the Ethical Committee of the University Medical Centre Groningen, where the study will be carried out. Data management and compliance to research policies and standards of our centre, including data privacy, storage and veracity, will be controlled by an independent monitor. All the scientific findings derived from this protocol are aimed to be made public through publication of articles in international journals.Trial registration numberNTR 5456; Pre-results.

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Kimura, M., M. Shimizu, M. Shirai, Y. Sakaguchi, K. Kobayashi, R. Iruya, S. Seki, et al. "P796 Effectiveness and safety of ustekinumab for patients with ulcerative colitis: A single-centre retrospective study." Journal of Crohn's and Colitis 17, Supplement_1 (January 30, 2023): i927—i928. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0926.

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Abstract Background Ustekinumab, a monoclonal antibody directed against the interleukin 12/23 p40 subunit, was approved worldwide in 2020 for the treatment of ulcerative colitis. The efficacy of ustekinumab in inducing and maintaining remission in moderate to severe ulcerative colitis was demonstrated in the phase 3 clinical study, the UNIFI trial; however, real-world data on the effectiveness and safety of ustekinumab for patients with ulcerative colitis is still scarce. We aimed to investigate the real-world effectiveness and safety of ustekinumab in patients with ulcerative colitis. Methods This was a single-centre retrospective study enrolling patients with ulcerative colitis who were aged 16 years or more and administered ustekinumab between March 2022 and March 2022 at Toho University Sakura Medical Center, a tertiary center. Data were extracted by chart review. Ustekinumab was administered as a single intravenous infusion (approximately 6 mg/kg) followed by 90mg subcutaneous injection at week 8 and then by 90mg subcutaneous injection every 8-12 weeks. The endpoints were 1) the proportion of patients achieving symptomatic remission, defined as a rectal bleeding score of 0 and a stool frequency score of 0 or 1 in patient-reported outcome-2 (PRO-2), at week 8, 2) time to discontinuation, and 3) safety during the observation periods. Results We enrolled 53 patients in this study, with a median age of 45 years (interquadrant range: 27-57). Thirty patients (56.6%) were male and 23 (43.4%) were female. The majority of patients (n=39; 73.6%) had extensive colitis. Notably, 21 (38.9%) patients were naïve to advanced therapies. Thiopurines had been administered to 24 (45.3%) patients. Twenty-one (39.6%) patients achieved symptomatic remission at week 8 after a single intravenous infusion. The proportion of patients with symptomatic remission was numerically higher in advanced therapy-naïve patients compared with advanced therapy-experienced patients (47.6% versus 34.4%) (Figure 1). Univariate analysis failed to identify clinical predictors for symptomatic remission at week 8. The time to discontinuation were significantly longer in advanced-therapy naïve patients compared with advanced therapy experienced patients, with a median observation period of 296 days (Figure 2). As for safety, one patient discontinued ustekinumab due to skin disorder. One death due to pneumonia was observed, which was unrelated to ustekinumab. Conclusion Ustekinumab was effective and safe in the real-world setting. Advanced-therapy naïve patients were more likely to continue ustekinumab compared with advanced therapy experienced patients.

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C. V., Jose, Lissiamma George, and Sunitha Sukumaran. "Does advanced maternal age influence obstetric outcome: a study in a tertiary care centre." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 4 (March 26, 2019): 1313. http://dx.doi.org/10.18203/2320-1770.ijrcog20190976.

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Background: Advanced maternal age defined as age 35 years and older at estimated date of delivery has become increasingly common in last two to three decades. The International Federation of Gynaecology and Obstetrics in 1958 recommended that all women going through their first pregnancy over the age of 35 years should be considered high risk for pregnancy and included in this category 1.Methods: A one-year prospective observational study conducted in a tertiary care hospital after institutional ethical clearance. All 165 women above 35yrs who delivered during this period were taken as Cohort 1. Same number of women aged between 20 and 34 years were randomly selected as comparison group (Cohort 2). Both the groups were compared in terms of preexisting medical disorders, obstetrical morbidities, antenatal complications, intrapartum complications.Results: Older and younger women had similar antenatal booking, occupational and socioeconomic status. The main reason for pregnancy at advanced age group was late marriage. The risk of chronic hypertension, gestational diabetes mellitus, pre-existing medical disorders were higher in advanced maternal age.Conclusions: Increasing maternal age is associated with elevated risks for pregnancy complications. They are at high risk for gestational diabetes, cesarean section and to have low birth weight babies. Since these women are at higher risk of complications, they should be advised to adhere to frequent antenatal visits and close supervision.

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De Jong, Michiel E., Sanne B. Van Tilburg, Loes H. C. Nissen, Wietske Kievit, Iris D. Nagtegaal, Carmen S. Horjus, Tessa E. H. Römkens, Joost P. H. Drenth, Frank Hoentjen, and Lauranne A. A. P. Derikx. "Long-term Risk of Advanced Neoplasia After Colonic Low-grade Dysplasia in Patients With Inflammatory Bowel Disease: A Nationwide Cohort Study." Journal of Crohn's and Colitis 13, no. 12 (July 7, 2019): 1485–91. http://dx.doi.org/10.1093/ecco-jcc/jjz114.

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AbstractBackground and AimsThe long-term risk of high-grade dysplasia [HGD] and colorectal cancer [CRC] following low-grade dysplasia [LGD] in inflammatory bowel disease [IBD] patients is relatively unknown. We aimed to determine the long-term cumulative incidence of advanced neoplasia [HGD and/or CRC], and to identify risk factors for advanced neoplasia in a nationwide IBD cohort with a history of LGD.MethodsThis is a nationwide cohort study using data from the Dutch National Pathology Registry [PALGA] to identify all IBD patients with LGD between 1991 and 2010 in the Netherlands. Follow-up data were collected until January 2016. We determined the cumulative incidence of advanced neoplasia and identified risk factors via multivariable Cox regression analysis.ResultsWe identified 4284 patients with colonic LGD with a median follow-up of 6.4 years after initial LGD diagnosis. The cumulative incidence of subsequent advanced neoplasia was 3.6, 8.5, 14.4 and 21.7%, after 1, 5, 10 and 15 years, respectively. The median time to develop advanced neoplasia after LGD was 3.6 years. Older age [≥ 55 years] at moment of LGD (hazard ratio [HR] 1.73, 95% confidence interval [CI] 1.44–2.06), male sex [HR 1.33, 95% CI 1.10–1.60], and follow-up at an academic [vs non-academic] medical centre [HR 1.37, 95% CI 1.07–1.76] were independent risk factors for advanced neoplasia following LGD.ConclusionsIn a large nationwide cohort with long-term follow-up of IBD patients with LGD, the cumulative incidence of advanced neoplasia was 21.7% after 15 years. Older age at LGD [≥55 years], male sex and follow-up by a tertiary IBD referral centre were independent risk factors for advanced neoplasia development after initial LGD.

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Hawkins, Janine, Nigel Smeeton, Amanda Busby, David Wellsted, Beth Rider, Julia Jones, Retha Steenkamp, et al. "Contributions of treatment centre and patient characteristics to patient-reported experience of haemodialysis: a national cross-sectional study." BMJ Open 11, no. 4 (April 2021): e044984. http://dx.doi.org/10.1136/bmjopen-2020-044984.

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ObjectivesTo examine the relative importance of patient and centre level factors in determining self-reported experience of care in patients with advanced kidney disease treated by maintenance haemodialysis (HD).DesignAnalysis of data from a cross sectional national survey; the UK Renal Registry (UKRR) national Kidney patient-reported experience measure (PREM) survey (2018). Centre-level data were obtained from the UKRR report (2018).SettingNational survey of patients with advanced kidney disease receiving treatment with maintenance HD in UK renal centres in 2018.ParticipantsThe Kidney PREM was distributed to all UK renal centres by the UKRR in May 2018. Each centre invited patients receiving outpatient treatment for kidney disease to complete the PREM. These included patients with chronic kidney disease, those receiving dialysis—both HD and peritoneal dialysis, and those with a functioning kidney transplant. There were no formal inclusion/exclusion criteria.Main outcome measuresThe Kidney PREM has 38 questions in 13 subscales. Responses were captured using a 7-point Likert scale (never 1, always 7). The primary outcome of interest was the mean PREM score calculated across all questions. Multilevel modelling was used to determine the proportion of variation of the mean PREM score across centres due to patient-related and centre-related factors.ResultsThere were records for 8253 HD patients (61% men, 77% white) from 69 renal centres (9–710 patients per centre). There was significant variation in mean PREM score across centres (5.35–6.53). In the multivariable analysis there was some variation in relation to both patient- and centre-level factors but these contributed little to explaining the overall variation. However, multilevel modelling showed that the overwhelming proportion of the explained variance (45%) was explained by variation between centres (40%), only a small proportion of which is identified by measured factors. Only 5% of the variation was related to patient-level factors.ConclusionsCentre rather than patient characteristics determine the experience of care of patients receiving HD. Further work is required to define the characteristics of the treating centre which determine patient experience.

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Choy, Petrus W. C., T. L. Yip, Kelvin Pang, and Eunha Lee. "A study of the critical success factors of international ship finance centre." Maritime Business Review 1, no. 1 (April 25, 2016): 40–54. http://dx.doi.org/10.1108/mabr-03-2016-0003.

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Purpose The purpose of this study is to identify the critical success factors to international ship finance centre (ISFC) and to understand the reasons behind ship financing decision by shipowners and their views on the potential of Shanghai to become an ISFC in the near future. Design/methodology/approach Survey questionnaire and follow-up interviews were conducted. The survey of this study was conducted by firstly sending online questionnaire with interview questions via email and then carrying out interview either on telephone or in-person with the interview questions to collect factual data and views from individual interviewees. Findings This study identified governmental support and stable policy, sound and favourable legal system, advanced maritime cluster and dynamic source of finance as critical success factors which can help Shanghai to evolve into an international maritime centre with dual function as an ISFC which is a synthesis with the maritime sector of an international finance centre. Originality/value This paper is known to be the first to link international maritime centre with ISFC.

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Babu, VenkataPradeep K., Vineet Talwar, Shubhra Raina, Varun Goel, PrasantaK Dash, Rajat Bajaj, Manish Sharma, et al. "Gemcitabine with carboplatin for advanced intrahepatic cholangiocarcinoma: A study from North India Cancer Centre." Indian Journal of Cancer 55, no. 3 (2018): 222. http://dx.doi.org/10.4103/ijc.ijc_622_17.

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Liu, Chao, Qi Jia, Haifeng Wei, Xinghai Yang, Tielong Liu, Jian Zhao, Yan Ling, et al. "Apatinib in patients with advanced chordoma: a single-arm, single-centre, phase 2 study." Lancet Oncology 21, no. 9 (September 2020): 1244–52. http://dx.doi.org/10.1016/s1470-2045(20)30466-6.

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Regan, Michael A., Thomas J. Triggs, and Stuart T. Godley. "Evaluation of a Novice Driver CD-Rom Based Training Program: A Simulator Study." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 44, no. 11 (July 2000): 334–37. http://dx.doi.org/10.1177/154193120004401101.

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The Monash University Accident Research Centre (MUARC) in Melbourne, Australia, recently completed research which culminated in the development of a CD ROM-based perceptual and cognitive skills training product for young novice car drivers. This paper describes the design of an experiment, using an advanced driving simulator located at MUARC, to evaluate the instructional effectiveness of the product.

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Natarajan, Kiran, Rahul Kurkure, Swathi ., Anubhav Shrivastava, Sowmya Gajapathy, and Mohan Kameswaran. "Management of advanced cholesteatoma: Madras ENT Research Foundation experience." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 6 (May 22, 2020): 1149. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20202216.

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Background: Cholesteatoma is a common condition encountered by the otolaryngologist in the Indian subcontinent. Due to absence of pain in most patients, they may have advanced disease at presentation. Lack of awareness, long distance between the patient’s home and the treatment centre are also reasons for late presentation. Surgical management is the mainstay of treatment. The aim of this study was to retrospectively analyze the number of patients with advanced cholesteatoma, the extent of disease, and associated complications.Methods: Fifty one patients out of a total of 1132 patients with cholesteatoma presented with advanced disease in a tertiary referral centre between January 2010 to January 2020. The surgical issues in the management of the disease and the outcomes were studied. Results: Fifty one patients presented with extensive cholesteatoma in a tertiary referral centre. There were 33 males and 18 females in the study. Of fifty one patients, pediatric cholesteatoma was seen in 6 patients. Hearing loss was the most common presentation. Facial palsy, labyrinthine fistula, dural involvement, internal auditory meatus involvement was noted in some patients. All patients underwent surgical management with good outcomes.Conclusions: Advanced cholesteatoma is a dreaded disease that can result in various complications. Involvement of the facial canal, labyrinth, cochlea, dura, internal auditory meatus, internal carotid artery, jugular bulb, and sigmoid sinus involvement in the presence of extensive disease should be identified before surgery. Appropriate treatment with complete disease clearance can result in good outcomes.

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Amarin, V. N., and H. F. Akasheh. "Advanced maternal age and pregnancy outcome." Eastern Mediterranean Health Journal 7, no. 4-5 (September 15, 2001): 646–51. http://dx.doi.org/10.26719/2001.7.4-5.646.

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To assess the effect of maternal age on obstetric intervention and pregnancy outcome, a retrospective study compared obstetric intervention, pregnancy complications and outcome in 73 women of age > 35 years with 471 women of age 20-25 years attending Prince Ali Military Hospital, Jordan from June 1999 to May 2000. Older women were found to have significantly higher rates of medical complications such as hypertension and diabetes mellitus. Despite significantly increased frequency of large babies, trisomy 21, twin pregnancy and antepartum haemorrhage, overall outcome was satisfactory. We conclude that older women, managed by modern obstetric methods and delivered in a modern health-care centre, can expect good pregnancy outcomes.

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Viswanathan, Kaladharan. "Kerala Kalamandalam: A legacy revisited." Indian Theatre Journal 7, no. 1 (June 1, 2023): 17–35. http://dx.doi.org/10.1386/itj_00032_1.

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The performance landscape of Kerala is diverse, and its history hails the glory of Kutiyattam, the sole surviving Sanskrit theatre tradition in India; Kathakali, the classical dance-drama; and Mohiniyattam, an exclusive female dance form. This is in addition to a huge variety of ritual and folk performance forms all over the region. While the first onstage recital of Kutiyattam performance and the subsequent development of its aesthetics and criticism date back to tenth and eleventh century AD, the entire Kathakali repertory originated and developed in the seventeenth century. On the other hand, Mohiniyattam seems to have originated even later. As a residential training centre for traditional performing arts in Kerala, Kalamandalam facilitated intense and uninterrupted communications amongst the top-ranking artists of various art forms. The Second World War had its devastating effects on the cultural institutions in India in general, and Kalamandalam in particular. Then, the Department of Education, Government of India, took over the administration of Kalamandalam. In 1976, Kalamandalam became a grant-in-aid institution under the Charities Registration Act and started functioning under a General Council and Executive Board constituted by the Government of Kerala. In 2006, Kalamandalam was deemed to be a university, functioning under the Cultural Affairs Department, Government of Kerala. The main objective of the institutional transformation was to combine practical training in different performing arts at the academic level. Several groups of students are now coming out of Kalamandalam every year after successfully completing their graduate and postgraduate programmes. Advanced training programmes are held at the Nila Campus in Cheruthuruthy, while the undergraduate courses are offered at the sprawling Vallathol Nagar Campus.

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Georgiev, Dejan, Sentilija Delalić, Nina Zupančič Križnar, Achinoam Socher, Tanya Gurevich, and Maja Trošt. "Switching and Combining Device-Aided Therapies in Advanced Parkinson’s Disease: A Double Centre Retrospective Study." Brain Sciences 12, no. 3 (March 2, 2022): 343. http://dx.doi.org/10.3390/brainsci12030343.

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Background: Device-aided therapies (DAT), such as continuous subcutaneous apomorphine infusion (CSAI), levodopa-carbidopa intestinal gel infusion (LCIG), and deep brain stimulation of the subthalamic nucleus (STN-DBS), have markedly changed the treatment landscape of advanced Parkinson’s disease (aPD). In some patients, it is necessary to switch or combine DATs for various reasons. The aim of this retrospective study was to explore the frequency and reasons for switching between or combining DATs in two movement disorders centres in Slovenia and Israel. Methods: We collected and analysed demographic and clinical data from aPD patients who switched between or combined DATs. Motor and non-motor reasons, adverse events for switching/combining, and their frequency were examined, as was the effect of DAT using the Global Improvement subscale of the Clinical Global Impression Scale, Movement Disorders Society Unified Parkinson’s Disease Rating Scale part III, Mini Mental State Examination, and Parkinson’s Disease Questionnaire 39. Descriptive statistics and non-parametric tests were used to analyse the data. Results: Of 505 aPD patients treated with DATs at both centres between January 2009 and June 2021, we identified in a total of 30 patients (6%) who either switched DAT (n = 24: 7 LCIG-to-STN−DBS, 1 LCIG-to-CSAI, 5 CSAI-to STN−DBS, 8 CSAI-to-LCIG, 1 STN−DBS-to-LCIG, 1 LCIG-to-CSAI-to-STN−DBS, and 1 STN−DBS-to-CSAI-to-LCIG) or combined DATs (n = 6:5 STN−DBS+LCIG and 1 STN−DBS+CSAI-to-STN−DBS+LCIG). In most of these patients, an inadequate control of motor symptoms was the main reason for switching or combining DATs, but non-motor reasons (related to the disease and/or DAT) were also identified. Conclusions: Switching between and combining DATs is uncommon, but in some patients brings substantial clinical improvement and should be considered in those who have either inadequate symptom control on DAT treatment or have developed DAT-related complications.

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Mishra, Seema, Sushma Bhatnagar, Freeny Ann Philip, Vasudha Singhal, Shiv Pratap Singh Rana, Surjya Prasad Upadhyay, and Govindi Chauhan. "Psychosocial Concerns in Patients With Advanced Cancer: An Observational Study at Regional Cancer Centre, India." American Journal of Hospice and Palliative Medicine® 27, no. 5 (February 18, 2010): 316–19. http://dx.doi.org/10.1177/1049909109358309.

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Heidrick, Ted R., John W. Kramers, and Marc C. Godin. "Deriving Value from Industry-University Partnerships: A Case Study of the Advanced Engineering Materials Centre." Engineering Management Journal 17, no. 3 (September 2005): 26–32. http://dx.doi.org/10.1080/10429247.2005.11415294.

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Moin, Muhammad, Lubna Siddiq Mian, Clare Gilbert, Abdullah Irfan, and Umar K. Mian. "Blindness in infants presenting with advanced and untreated ROP: a single-centre study in Pakistan." BMJ Open Ophthalmology 7, no. 1 (November 2022): e000911. http://dx.doi.org/10.1136/bmjophth-2021-000911.

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ABSTRACTPurposeTo describe the ocular features and characteristics of young children presenting with advanced, untreated retinopathy of prematurity and to determine appropriate screening guidelines for retinopathy of prematurity (ROP) in Pakistan.Material and methodsA retrospective case series of young children with stage5A or 5B or cicatricial changes (4B or 4A ROP) was undertaken in the Department of Ophthalmology, Lahore General Hospital, Lahore, Pakistan, from August 2017 to July 2019. Information was obtained from interviewing parents and from neonatal care discharge summaries, if available. An assessment of visual function and a dilated fundus examination were performed.Results51 children presented at mean age of 9.7 (1.5–36) months. Their mean gestational age (GA) was 28.84 (26–38) weeks, and mean birth weight (BW) was 1229 (800–2100) g. Four children (7.8%) had a GA of >31 weeks plus a BW of >1501 g. 40 (76.4%) children were blind and 11 (23.6%) had impaired vision. Sixty-five eyes (63.7%) had stage 5B; 13 (12.7%) eyes had stage 5A; 18 (17.6%) had falciform macular folds (4B ROP) and 6 eyes (5.9%) had macular dragging (4A ROP). 39 (76.5%) children had bilateral stage 5A/5B. Half (47%) of the children lived outside the capital city of Lahore, and 15 came from small cities (population <1 million).ConclusionThe third epidemic of blindness due to ROP has arrived in Pakistan, and premature babies are going blind even in smaller cities. Initial screening guidelines of a GA of ≤35 weeks and BW of ≤2000 g seem reasonable. There is an urgent need to improve the quality of neonatal care and to increase the coverage of ROP screening and treatment services across the country.

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Graham, Janet S., Stephen Falk, Leslie M. Samuel, Josep M. Cendros, and T. R. Jeffry Evans. "A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy." Cancer Chemotherapy and Pharmacology 63, no. 5 (July 25, 2008): 945–52. http://dx.doi.org/10.1007/s00280-008-0795-6.

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Schummer, Patrick, Valerie Glutsch, Lukas Haug, Mathias Rosenfeldt, Johann Lock, Michael Meir, Agmal Scherzad, et al. "Neoadjuvant ipilimumab plus nivolumab in locally advanced melanoma: A real-world single-centre retrospective study." EJC Skin Cancer 1 (2023): 100003. http://dx.doi.org/10.1016/j.ejcskn.2023.100003.

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Shah, Narender Singh, Dhiraj Daga, Deepti Singh, Manish Kumar Chaturvedi, Upen Kishor Mathur, Poonam Banthia, and Ashish Kavia. "Retrospective Study of Palliative Radiotherapy in Locally Advanced and Metastatic Head and Neck Carcinoma: A Single Institution Study." Bengal Journal of Otolaryngology and Head Neck Surgery 29, no. 3 (March 18, 2022): 231–37. http://dx.doi.org/10.47210/bjohns.2021.v29i3.514.

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Introduction The most common cancer of India is head and neck, and about 70% of them present in locally advanced or metastatic disease. Palliative radiotherapy is one of the commonly used treatments in such cases. A retrospective study on the outcomes and toxicity of palliative radiotherapy is studied at a tertiary centre. Materials and Methods In this study, 74 patients who underwent palliative radiotherapy at the tertiary centre between Nov 2017 and Oct 2019 were retrospectively analysed. The frequency of different presenting symptoms, radiotherapy regimens, their outcome in form of symptomatic relief and disease status along with toxicity was studied and analysed through the available records. Results We identified 74 eligible patients. The median age was 48years (range, 26–82). Oropharyngeal primary cancer was the most common primary site. The Eastern Cooperative Oncology Group performance status was 3 or more in 74.4% patients. The radiation regimen used were ranged from 8Gyin single fraction, 20Gy in 4 fractions, 20Gy in 5 fractions, 30Gy in 10 fractions and 60Gy in 30 fractions. 93.2% of them completed their treatment. Pain and swelling were the most common presenting symptoms and 90.6% of them had more than 50% relief, while 46.5% had complete or partial response to the treatment. Conclusion Palliative radiotherapy to the head and neck provides some symptomatic benefit in most patients, there are multiple dose fractionation regimens currently being used for palliative radiation treatment, and consideration should be given to higher dose palliative RT regimens in patients having good performance status to maximize locoregional control and minimize late toxicity, patient with poor performance status will benefit from a hypofractionated palliative radiation treatment.

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Burwell, Kim. "Issues of dissonance in advanced studio lessons." Research Studies in Music Education 41, no. 1 (May 3, 2018): 3–17. http://dx.doi.org/10.1177/1321103x18771797.

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In recent years researchers have contributed a great deal to our shared understanding of the complexities of studio practices, which are widely regarded as a centre-point of higher education music. This article investigates an aspect of studio learning that does not lend itself easily to scrutiny, by drawing common issues from the cases of two students who, exceptionally, reported dissatisfaction with the approaches taken by their current teachers. These issues, loosely grouped under the metaphor of dissonance, are explored through interview and observation evidence, in terms of the balance of activity within lessons, turn taking, and encouragement. The study gives rise to questions that might be applied, arguably, in any studio setting.

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Wolny, Daniel, Ladislav Štěpánek, Dagmar Horáková, Janet Thomas, Jana Zapletalová, and Mihir Sanjay Patel. "Risk Factors for Non-Healing Wounds—A Single-Centre Study." Journal of Clinical Medicine 13, no. 4 (February 9, 2024): 1003. http://dx.doi.org/10.3390/jcm13041003.

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Background: Chronic wounds present a significant clinical, social, and economic challenge. This study aimed to objectify the risk factors of healing outcomes and the duration of chronic wounds from various etiologies. Methods: Patients treated for non-healing wounds at the surgical outpatient clinic of the Olomouc Military Hospital were involved. Data from patients treated between 8/2021 and 9/2023 were selected. Patients were mostly treated as outpatients, with microbiological follow-up indicated in cases of advanced signs of inflammation. Results: There were 149 patients who met our selection criteria (the mean age was 64.4 years). Predominant causes of wounds involved diabetes (30.9%), post-trauma (25.5%), pressure ulcers (14.8%), surgical site infections (14.8%), and vascular ulcers (14.1%). Patient outcomes included wound resolution in 77.2% of patients (with a mean healing time of 110.9 days), amputation in 14.1%, and wound-related death in 8.7% of patients. Non-healing cases (amputation/death) were predicted by several local factors including an initial depth greater than 1 cm, wound secretion, inflammatory base, and a maximum wound size. Systemic factors included most strongly clinically manifested atherosclerosis and its risk factors. Of the 110 swabs performed, 103 identified at least 1 bacterial genus. The dominant risk factor for a prolonged healing duration was bacterial infection. Wounds contaminated by Proteus or Pseudomonas had prolonged healing times of 87 days (p = 0.02) and 72 days (p = 0.045), respectively. Conclusions: The early identification of local and systemic risk factors contributes to the successful resolution of chronic wounds and a reduced duration of healing.

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Lazzaro, Carlo, Francesco Plotti, Stella Capriglione, Matteo Ferrario, and Roberto Angioli. "Cost of illness of advanced ovarian carcinoma in Italy: results of an empirical, single-centre study." Farmeconomia. Health economics and therapeutic pathways 16, no. 3 (September 30, 2015): 61–76. http://dx.doi.org/10.7175/fe.v16i3.1181.

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AIM: To perform an empirical, single-centre, retrospective and secondary cost of illness (COI) study of advanced ovarian carcinoma (AOC) in Italy. METHODS: Demographic, clinical, health care and non-health care resource consumption data concerning a convenience sample of subsequent patients in 1st line of treatment (100 patients), 2nd line of treatment A (surgery + chemotherapy; 30 patients) and 2nd line of treatment B (chemotherapy only; 20 patients) were obtained from a database created in 2011 by the Obstetrics and Ginecology Unit at Campus Biomedico teaching hospital, Rome. Patients were followed-up for 2 years. Resources were valued according to the above mentioned database and literature, following the societal viewpoint. Costs are expressed in Euro (€) 2014 and reported as mean and standard deviation (SD). RESULTS: One-year COI for 1st line of treatment reaches € 44,999.7 (SD: €28,757.3), € 55,410.8 (SD: € 32,454.6) and €46,895.6 (SD: € 28,407.4) for 2nd line of treatment A and B, respectively. Regardless the line of treatment, COI is mainly driven by cost borne by patient and her family. Due to the high costs of relapse the mean COI per patient after 2 years from the diagnosis of AOC equals € 81,869.4 (SD: € 30,660.9), or 182% of the COI for the 1st line of treatment. CONCLUSIONS: Despite some limitations, our results show that increasing progression-free survival could well reduce the COI for AOC in Italy.

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Borysiewicz, Zuzanna, and Iwona Ryniewicz-Zander. "Toxicity profile of lapatinib plus capecitabine in advanced breast cancer – a single-centre follow-up study." OncoReview 5, no. 4 (December 30, 2015): 164–68. http://dx.doi.org/10.5604/20828691.1189750.

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Colle, Royal D., and M. P. Saxena. "The Centre of Advanced Studies in Agricultural Communication: A Case Study of Institution Building in India." Media Asia 13, no. 3 (January 1986): 137–43. http://dx.doi.org/10.1080/01296612.1986.11726220.

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Lim, Li Hoon, Eric Pei Ping Pang, Hansa Jadva-Patel, and Sharon Mei Mei Wong. "Perceptions on site-specific advanced practice roles for radiation therapists in Singapore – A single centre study." Technical Innovations & Patient Support in Radiation Oncology 13 (March 2020): 17–20. http://dx.doi.org/10.1016/j.tipsro.2019.11.010.

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Du, Yang, Xiao-Yian Liu, RuiLi Pan, Xiao-Tong Zhang, Xiao-Yan Si, Minjiang Chen, Mengzhao Wang, and Li Zhang. "Tocilizumab for advanced non-small cell lung cancer with concomitant inflammatory cachexia: A single-centre study." Journal of Clinical Oncology 42, no. 16_suppl (June 1, 2024): 2647. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.2647.

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2647 Background: Cancer cachexia significantly contributes to morbidity and mortality in patients with non-small cell lung cancer (NSCLC). Inflammatory pathways mediated by interleukin-6 play a crucial role in the development of cancer cachexia. This study aimed to investigate the use of tocilizumab, an anti-interleukin-6 receptor inhibitor, in the management of NSCLC with coexisting inflammatory cachexia. Methods: Data were collected from patients with NSCLC and concurrent inflammatory cachexia who received either tocilizumab plus anti-tumour therapy or anti-tumour therapy alone. The primary endpoints were overall survival (OS) and improved modified Glasgow Prognostic Score (mGPS) at week 12, while secondary endpoints included changes from baseline over 12 weeks in body weight, albumin, C-reactive protein and mGPS. Qualitative improvements in patient self-rated appetite and fatigue were reported as exploratory analysis. Results: The study included 49 patients diagnosed with NSCLC and coexisting inflammatory cachexia, of which 26 received tocilizumab in combination with anti-tumour therapy, and 23 received anti-tumour therapy alone. The tocilizumab group demonstrated a significantly longer median OS compared to the control group (15.1 vs. 3.2 months; hazard ratio 0.18, 95% confidence interval 0.08-0.38; p < 0.001). The rate of patients surviving with mGPS improvement at week 12 was significantly higher in the tocilizumab group than in the control group (OR 168.7, 95% CI 16.3-1746.5; p < 0.001). Over the 12-week period, significant improvements were observed in body weight, albumin, C-reactive protein, and mGPS in the tocilizumab group compared to the control group. Additionally, the tocilizumab group displayed significantly higher rates of improvement in appetite and fatigue. The incidence of grade 3 or higher adverse events was 34.6% in the tocilizumab group compared to 78.3% in the control group. Tocilizumab-related adverse events were observed in three patients (11.5%), including two cases of neutropenia and one case of skin and subcutaneous tissue infection. Conclusions: Tocilizumab demonstrated significant benefits in survival and various clinical parameters, including body weight, albumin, C-reactive protein, mGPS, and symptom burden in patients with NSCLC and concurrent inflammatory cachexia. Given the existing unmet medical need for effective interventions for cancer cachexia, tocilizumab may be considered as a potential treatment option.

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Filice, A., A. Fraternali, A. Frasoldati, M. Asti, E. Grassi, L. Massi, M. Sollini, A. Froio, P. A. Erba, and A. Versari. "Radiolabeled Somatostatin Analogues Therapy in Advanced Neuroendocrine Tumors: A Single Centre Experience." Journal of Oncology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/320198.

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The aim of this study was to assess the efficacy of PRRT in patients with advanced neuroendocrine tumors (NETs).Patients and Methods. From January 2007 to August 2011, we enrolled 65 patients (m/f 38/27; mean age 65 years, range 33–83) with advanced NETs having enhanced SSTR expression, treated with PRRT. The enhanced expression of SSTR was assessed using68Ga-DOTATOC/DOTATATE PET/CT. Among all the enrolled patients, 6 of them were excluded from the present analysis since they voluntarily interrupted treatment. Mean activity/cycle of 2.6 GBq (90Y-DOTATOC/DOTATATE) or 6.0 GBq (177Lu-DOTATOC/DOTATATE) was administrated intravenously (max 9 cycles).Results. Complete response (CR) was found in 1/59 (2%) patients, partial remission (PR) in 24/59 (40.5%) patients, stable disease (SD) in 24/59 (40.5%), and progression (PD) in 10/59 (17%) patients. The overall tumor response rate (CR + PR) was 42.5%. In 40.5% of patients, the disease could be stabilized. Overall, 49 out of 59 patients had no tumor progression (83%). Twelve patients out of 59 (20%) had grade 2-3 hematological side effects including anemia, thrombocytopenia, and leukopenia. Long-term nephrotoxicity was observed in 3 patients (2 moderate, 1 severe).Conclusions. PRRT is a promising perspective for patients with advanced NETs.

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King, Anthony J., Gordon Fernie, Augusto Azuara-Blanco, Jennifer M. Burr, Ted Garway-Heath, John M. Sparrow, Luke Vale, et al. "Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma—study protocol." British Journal of Ophthalmology 102, no. 7 (October 26, 2017): 922–28. http://dx.doi.org/10.1136/bjophthalmol-2017-310902.

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BackgroundPresentation with advanced glaucoma is the major risk factor for lifetime blindness. Effective intervention at diagnosis is expected to minimise risk of further visual loss in this group of patients.AimTo compare clinical and cost-effectiveness of primary medical management compared with primary surgery for people presenting with advanced open-angle glaucoma (OAG).MethodsDesign: A prospective, pragmatic multicentre randomised controlled trial (RCT).SettingTwenty-seven UK hospital eye services.ParticipantsFour hundred and forty patients presenting with advanced OAG, according to the Hodapp-Parish-Anderson classification of visual field loss.InterventionParticipants will be randomised to medical treatment or augmented trabeculectomy (1:1 allocation minimised by centre and presence of advanced disease in both eyes).Main outcome measuresThe primary outcome is vision-related quality of life measured by the National Eye Institute—Visual Function Questionnaire-25 at 24 months. Secondary outcomes include generic EQ-5D-5L, Health Utility Index-3 and glaucoma-related health status (Glaucoma Utility Index), patient experience, visual field measured by mean deviation value, logarithm of the mean angle of resolution visual acuity, intraocular pressure, adverse events, standards for driving and eligibility for blind certification. Incremental cost per quality-adjusted life-year (QALY) based on EQ-5D-5L and glaucoma profile instrument will be estimated.ResultsThe study will report the comparative effectiveness and cost-effectiveness of medical treatment against augmented trabeculectomy in patients presenting with advanced glaucoma in terms of patient-reported health and visual function, clinical outcomes and incremental cost per QALY at 2 years.ConclusionsTreatment of Advanced Glaucoma Study will be the first RCT reporting outcomes from the perspective of those with advanced glaucoma.Trial registration numberISRCTN56878850, Pre-results.

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Shah, Bashir Ahmed, Muzafar Ahmed Naik, Sajjad Rajab, Syed Muddasar, Ghulam Nabi Dhobi, Afaq A. Khan, Khursheed A. Banday, and Shabir Baba. "Serum Magnesium Levels in Exacerbation of COPD: A Single Centre Prospective Study from Kashmir, India." JMS SKIMS 13, no. 1 (June 21, 2010): 15–19. http://dx.doi.org/10.33883/jms.v13i1.38.

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Objective: To study the significance of serum magnesium levels during COPD exacerbation and stability.Materials & Methods: The patient population consisted of all patients of COPD admitted as acute exacerbation as defined by the Anthonisens criteria, from June 2006 to may 2008. Same patients one month post discharge presenting to the OPD for routine check up as stable COPD served as controls. Results: A total number of 77 patients of COPD presenting as acute exacerbation were included in the study. The incidence of Hypomagnesaemia was 33.8% at admission; 5% at discharge and 4% at one month of post discharge in COPD patients. The mean serum magnesium levels were significantly lower in cases than controls (1.88±0.67mg/ dl V/S 2.3±0.36mg/dl; p<0.0001). Also, hypomagnesemia was present in higher number of cases (22/77, 33.8%) compared to controls, 3/75, 4.0%; (p<0.0001). Patients of COPD with acute exacerbation and hypomagnesemia, had longer duration of symptoms and had advanced stage III of COPD (p<0.001); and had raised mean corpuscle volume (p<0.045) and longer hospital stay (p<0.008). Conclusion: We conclude COPD exacerbation is associated with hypomagnesemia. The duration of symptoms of more than 8 days, advanced stage of COPD (stage III) and raised MCV were associated with hypomagnesemia. We recommend to monitor serum magnesium levels in COPD patients with acute exacerbation at the time of admission and during their stay in the hospital.J Med Sci.2010;13(1);15-19

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Pant, Pankaj, Shovit Thapa, Santa K. Das, and Niraj Bam. "Serum Vitamin D Level in Chronic Obstructive Pulmonary Disease and its Relation with Severity: A Single Centre Study." Journal of Institute of Medicine Nepal 41, no. 2 (December 4, 2019): 56–58. http://dx.doi.org/10.3126/jiom.v41i2.26552.

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Introduction: Chronic obstructive pulmonary disease (COPD) is a public health problem of epidemic proportion. Several studies have shown low serum vitamin D levels in patients with COPD. The aim of this study was to compare serum vitamin D level in patients with Global Initiative for Chronic Obstructive Lung Diseases (GOLD) COPD stage II, III and IV with controls and correlate serum vitamin D level with severity of COPD. Methods: A cross sectional study was conducted from June 2014 to November 2015 at Tribhuvan University Teaching Hospital (TUTH). A total of 154 subjects were enrolled for study that consisted of 77 cases of COPD and 77 controls for comparison. Participants were taken from medical wards and outpatient department. COPD staging was done as per GOLD guidelines and stage II, III and IV were labeled as advanced COPD cases. Both descriptive and inferential statistics were performed in SPSS version 20. Results: Stage II, III and IV COPD were 30%, 36% and 34% respectively. Mean serum vitamin D level was 15.16±7.19 ng/ml in COPD cases and 33.99±12.37 ng/ml in healthy controls showing statistically significant relation of low serum vitamin D in patients with advanced COPD (p <0.0001). Serum vitamin D was found to be in decreasing trend with increasing severity of COPD. Conclusion: Patients with advanced COPD (GOLD stage II, III and IV) had low serum vitamin D levels compared to normal population and serum vitamin D level correlated with GOLD severity in Nepalese patients with COPD.

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Pant, Pankaj, Shovit Thapa, Santa K. Das, and Niraj Bam. "Serum Vitamin D Level in Chronic Obstructive Pulmonary Disease and its Relation with Severity: A Single Centre Study." Journal of Institute of Medicine Nepal 41, no. 2 (August 31, 2019): 56–58. http://dx.doi.org/10.59779/jiomnepal.1045.

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Introduction: Chronic obstructive pulmonary disease (COPD) is a public health problem of epidemic proportion. Several studies have shown low serum vitamin D levels in patients with COPD. The aim of this study was to compare serum vitamin D level in patients with Global Initiative for Chronic Obstructive Lung Diseases (GOLD) COPD stage II, III and IV with controls and correlate serum vitamin D level with severity of COPD. Methods: A cross sectional study was conducted from June 2014 to November 2015 at Tribhuvan University Teaching Hospital (TUTH). A total of 154 subjects were enrolled for study that consisted of 77 cases of COPD and 77 controls for comparison. Participants were taken from medical wards and outpatient department. COPD staging was done as per GOLD guidelines and stage II, III and IV were labeled as advanced COPD cases. Both descriptive and inferential statistics were performed in SPSS version 20. Results: Stage II, III and IV COPD were 30%, 36% and 34% respectively. Mean serum vitamin D level was 15.16±7.19 ng/ml in COPD cases and 33.99±12.37 ng/ml in healthy controls showing statistically significant relation of low serum vitamin D in patients with advanced COPD (p <0.0001). Serum vitamin D was found to be in decreasing trend with increasing severity of COPD. Conclusion: Patients with advanced COPD (GOLD stage II, III and IV) had low serum vitamin D levels compared to normal population and serum vitamin D level correlated with GOLD severity in Nepalese patients with COPD.

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Waton, Anthony, Rachel Prichard, Carolina Navarro Rodriquez, Nicola Hannaway, Ashraf Azzabi, Robert Chandler, John A. Frew, Xue Yan Jiang, Rachel Pearson, and Ian Pedley. "Optimising bone health management in advanced prostate cancer: A comparative cohort study." Journal of Clinical Oncology 41, no. 6_suppl (February 20, 2023): 133. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.133.

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133 Background: Survival in prostate cancer is increasing due to advances in hormonal therapy. The recommended duration of Androgen Deprivation Therapy (ADT) is 18 months or more for patients with Non-Metastatic (NM) high risk disease, and lifelong in Metastatic disease. ADT is, however, an independent risk factor for osteoporosis, a disease characterised by low Bone Mineral Density (BMD) and subsequent increased risk of fractures, which can lead to significant disability and early death. In patients with advanced prostate cancer, it is therefore recommended that BMD is assessed yet there remains no established national guidance on how bone health should be managed. Methods: In total, 515 case notes for patients with newly diagnosed advanced hormone sensitive prostate cancer were retrospectively reviewed for assessment of bone health management. Our data analysis included a comparison of outcomes between patient cohorts managed at a dedicated Cancer Bone Health Unit (CBHU) and the Northern centre for Cancer Care (Oncology Centre, OC). Results: 1) Baseline characteristics: The cohorts were well balanced in terms of age and cancer stage. Data was available for 410 patients in the CBHU and 105 in the OC. Median age was 75 (range 59-94) in the CBHU and 71 (range 46-86) in the OC. The majority of patients had metastatic disease and were therefore receiving lifelong ADT. 2) Fracture incidence: was consistently higher in the OC (p<0.001). The most common fractures were hip, spine and wrist. Median time to first fracture in the CBHU was 112 (range 2 to 240) vs 83 weeks (8 to 229) in the OC (p=0.252). 3) Survival: for all patients 2 years after ADT commenced was 96.7% in the CBHU vs 91.8% in the OC (HR 0.321, 95% CI 0.19-0.55, p<0.001). Median survival has not yet been reached. Conclusions: This comparative analysis suggests that a strategy of standardised bone health management within a CBHU is associated with reduced fracture incidence and may delay time to first fracture compared with clinician discretion in an OC. Additionally the data suggests that this strategy also improves survival at 2 years in patients with NM high risk disease. Bone health strategies for prostate cancer should be implemented within hospital trusts to provide standardised care across the region. This could reduce costs associated with fractures and improve quality of life for patients who avoid fractures through timely introduction of treatment. The Northern Cancer Alliance (NCA) has recently approved guidance on the management of bone health in prostate cancer, and implementation has since commenced.

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Wong, J. Y. "Optimization of the Tractive Performance of Articulated Tracked Vehicles Using an Advanced Computer Simulation Model." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 206, no. 1 (January 1992): 29–45. http://dx.doi.org/10.1243/pime_proc_1992_206_158_02.

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This paper describes the results of a study of the effects of articulation joint configuration, suspension characteristics, location of the centre of gravity and initial track tension on the mobility of a two-unit, articulated tracked vehicle. The study was carried out using a comprehensive computer simulation model known as NTVPM-86. The results show that suspension characteristics, location of the centre of gravity and initial track tension have noticeable effects on the mobility of articulated tracked vehicles over marginal terrain, while the articulation joint angle has a less significant influence on vehicle performance. Locking the articulation joint between the two units of an articulated tracked vehicle usually causes a degradation of tractive performance. The approach to the optimization of the design of articulated tracked vehicles is demonstrated. It is shown that the simulation model NTVPM-86 can play a significant role in the optimization of articulated tracked vehicle design or in the evaluation of vehicle candidates for a given mission and environment.

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Mane, Vaibhav Pandurang, Darshana Narayan Wakkar, and Prashant Shrimant Dorkar. "Study of histomorphological spectrum of malignant breast diseases- In a tertiary care centre of Mumbai." Indian Journal of Pathology and Oncology 8, no. 3 (August 15, 2021): 334–39. http://dx.doi.org/10.18231/j.ijpo.2021.066.

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Breast cancer is the most common cancer in women worldwide, comprising 16% of all -female cancers. It is by far the most frequent cancer in female, both in developed and developing regions and is second overall next only lung. In India, breast cancer is the most common cancer among women in many regions and has overtaken cervix cancer, which was the most frequent cancer a decade ago 5 As in other developing regions, the mortality rates for breast cancer in India are high in comparison to its incidence rates. A poor survival may be largely explained by the lack of or limited access to the early detection services and treatment. Though clinical examination of the breast lump and the age of the patient can provide information about the nature of the lump, Histopathological examination is necessary to establish the diagnosis. To classify the breast lesions and study them with age, clinical presentation and various pathological parameters. The present study of the breast lesions was performed in the department of pathology in a general teaching hospital and tertiary referral health care centre in Mumbai. All the assimilated data was collected and analysed to find the incidence and frequency of lesions. Infiltrating duct carcinoma (IDC) is the most common breast malignancy. Grade -2 IDC’s were more common than grade- 1 and grade-3 IDC’s. Breast cancers were bulky and presented at an advanced stage in younger population. Breast carcinomas in our population presents as locally advanced cancer, with predominance of higher histological grade and higher stage in view of lack of or limited access to the early detection services and treatment.

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Scott, Jennifer, Eithne Nic an Ríogh, Shamma Al Nokhatha, Cliona Cowhig, Alyssa Verrelli, Ted Fitzgerald, Arthur White, et al. "ANCA-associated vasculitis in Ireland: a multi-centre national cohort study." HRB Open Research 5 (December 1, 2022): 80. http://dx.doi.org/10.12688/hrbopenres.13651.1.

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Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare multisystem autoimmune disease. There is a need for interoperable national registries to enable reporting of real-world long-term outcomes and their predictors in AAV. Methods: The Irish National Rare Kidney Disease (RKD) registry was founded in 2012. To date, 842 patients with various forms of vasculitis have been recruited across eight nephrology, rheumatology and immunology centres. We focus here on patient- and disease- characteristics, treatment and outcomes of the 397 prospectively recruited patients with AAV. Results: Median age was 64 years (IQR 55–73), 57.9% were male, 58.9% had microscopic polyangiitis and 85.9% had renal impairment. Cumulative one- and five-year patient survival was 94% and 77% respectively. Median follow-up was 33.5 months (IQR 10.7–52.7). After controlling for age, baseline renal dysfunction (p = 0.04) and the burden of adverse events (p <0.001) were independent predictors of death overall. End-stage-kidney-disease (ESKD) occurred in 73 (18.4%) patients; one- and five-year renal survival was 85% and 79% respectively. Baseline severity of renal insufficiency (p = 0.02), urine soluble CD163 (usCD163) (p = 0.002) and “sclerotic” Berden histological class (p = 0.001) were key determinants of ESKD risk. Conclusions: Long-term outcomes of Irish AAV patients are comparable to other reported series. Our results emphasise the need for personalisation of immunosuppression, to limit treatment toxicity, particularly in those with advanced age and renal insufficiency. Baseline usCD163 is a potential biomarker for ESKD prediction and should be validated in a large independent cohort.

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Matsubara, Chieko, Maxwell Ayindenaba Dalaba, Laata Latif Danchaka, and Paul Welaga. "Situation Analysis of a New Effort of Community-Based Health Planning and Services (CHPS) for Maternal Health in Upper West Region in Rural Ghana." International Journal of Environmental Research and Public Health 20, no. 16 (August 18, 2023): 6595. http://dx.doi.org/10.3390/ijerph20166595.

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A free maternal health policy started in Ghana in 2008, however, health facility utilization is still low, and out-of-pocket payments (OOPPs) are putting households at risk of catastrophic expenditure. To improve this situation, some rural communities have assigned a midwife to a health post called community-based health planning and services (CHPS), where only assistant nurses are allocated. This study explored the effectiveness of the new approach in Upper West Region, Ghana. We conducted a cross-sectional study and interviewed women who gave birth in the last year. We systematically selected communities matched into four criteria: communities near CHPS (functional CHPS), communities near CHPS with a midwife (advanced CHPS), communities near a health centre, and communities without a health facility in their neighbourhood. In total, 534 women were interviewed: functional CHPS 104, advanced CHPS 131, near health centre 173, and no facility 126. About 78% of the women were 20 to 34 years old. About half of the women incurred OOPP, however, catastrophic payment (household spending > 5% of annual income) was significantly lower in advanced CHPS communities for normal delivery compared with the other three communities. The new local approach of assigning a midwife to CHPS functioned well, improving access to healthcare facilities for childbirth.

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John, Afra, Robert P. Ambooken, and Anil A. "Non-alcoholic fatty liver disease- correlation between shear wave elastography and nafld fibrosis score: a descriptive single centre study." International Journal of Research in Medical Sciences 10, no. 6 (May 27, 2022): 1271. http://dx.doi.org/10.18203/2320-6012.ijrms20221481.

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Background: Due to the global burden of obesity and type 2 diabetes, prevalence of NAFLD is now increasing, becoming one of the most common cause of chronic liver disease and liver transplantation both for end-stage liver disease and hepatocellular carcinoma. Although traditionally liver biopsy is gold standard for diagnosis of NAFLD, majority of patients can be non-invasively diagnosed with various tools like scoring systems (NAFLD fibrosis score, BARD score), ultrasound and MR elastographic techniques. The primary objective of this study was to assess the liver stiffness measurement by shear wave elastography and assess correlation between LSM by SWE and NAFLD fibrosis score in NAFLD patients.Methods: This is a descriptive study comprising 75 patients with clinical suspicion of NAFLD, referred from Gastroenterology department from January 2020 to June 2021. All patients had undergone SWE, NAFLD fibrosis score calculated and results analyzed.Results: Among the 75 patients studied, applying low cut off value of NAFLD fibrosis score (below -1.455), the presence of advanced fibrosis was excluded and by applying the high cut off point (>0.676) majority of subjects had advanced fibrosis. The NAFLD fibrosis score was correlated with E median values of liver stiffness measurement using Pearson correlation test and showed a moderate positive correlation (p=0.0001, =0.685) between both the variables.Conclusions: Our study showed positive moderate correlation between NAFLD fibrosis score and LSM by 2D SWE. Multistep strategies using liver 2D SWE and NAFLD fibrosis score in combination can be used in the future to accurately diagnose or exclude the presence of advanced fibrosis in NAFLD patients.

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Kusumajaya, Christopher, and Ferry Safriadi. "Characteristics of Penile Cancer at Tertiary Centre Hospital: A Nine Years Study from 2010-2019." Indonesian Journal of Cancer 16, no. 1 (April 1, 2022): 28. http://dx.doi.org/10.33371/ijoc.v16i1.832.

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Background: Penile cancer is a rare and aggressive disease. The incidence in India, Africa, and South America ranges from 2.3 to 8.3 per 100,000. No data regarding incidence rates in Indonesia. The etiological factors include poor genital hygiene, phimosis, tobacco use, multiple sex partners, human papillomavirus (HPV) infection, and chronic inflammatory states. Squamous cell carcinoma (SCC) represents 95% of penile cancers. Progression and treatment of the disease cause devastating consequences and morbidity such as disfiguring penile amputation. This study aimed to assess the epidemiological characteristics of penile cancer in the city of Bandung, its associated risk factors, clinical manifestations, and compare the results with previous studies. Methods: This was a descriptive study conducted at Hasan Sadikin Hospital Bandung from January 2010 to 2019. The study included all penile cancer patients that came to Urology Department. Variables such as age, history of circumcision, phimosis, HPV infection, marital status, smoking habit, educational level, age of onset, operation, histopathological results, history of multiple sex partners, location of the tumor, comorbidities, and staging are collected from the medical record and analyzed. Results: A total of 13 penile cancer patients were involved with the age range from 28 to 67 years and 50.69 years on average. Most of them were smokers (69.2%) and uncircumcised (53.8%). All of the patients came at an advanced stage, and penectomy was done. Histopathologically, 84.6% were SCC. One of our patients was consulted by a haemato-oncologist for adjuvant chemotherapy (6 cycles of cisplatin and 5-fluorouracil). Conclusions: Penile cancer is a rare neoplasm in Bandung, West Java. The characteristics of penile cancer patients found in our hospitals were on average 50.7 years old, and the most risk factors found were smoking and uncircumcised. Histopathologically, most of them were SCC. All patients came to seek medical treatment at an advanced stage and had undergone surgical penectomy.

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Rianyta, Rianyta, Melva Louisa, Elisna Syahruddin, and Vivian Soetikno. "Observational Study of Paclitaxel-Carboplatin versus Pemetrexed-Carboplatin for Advanced Pulmonary Adenocarcinoma at Single-Centre in Indonesia." eJournal Kedokteran Indonesia 9, no. 3 (January 31, 2022): 178–86. http://dx.doi.org/10.23886/ejki.9.16.178-86.

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Platinum-based chemotherapy regimens with two types of drugs, such as paclitaxel-carboplatin and pemetrexedcarboplatin, are first-line therapy for pulmonary adenocarcinoma patients with negative epidermal growth factor receptor (EGFR) mutation. This study aimed to determine the efficacy, toxicity, and cost profile of paclitaxel-carboplatin compared to pemetrexed-carboplatin. This is a cross-sectional study. Pulmonary adenocarcinoma negative EGFR mutation naïve patients treated with paclitaxel-carboplatin or pemetrexed-carboplatin were included. Effectiveness was assessed based on the overall response rate (ORR) according to the response evaluation criteria in solid tumours (RECIST). A pharmacoeconomic analysis is performed based on clinical outcomes consisting of effectiveness and direct medical costs. Medical records from 21 patients with paclitaxel-carboplatin and 21 patients with pemetrexedcarboplatin were successfully evaluated. The effectiveness of the two chemotherapy regimens was not significantly different (OR, 1.25; 95% confidence interval, 0.34 to 4.64; p = 0.739). Frequent haematological toxicities experienced in the two groups were grade 1-2 anaemia, neutropenia, leukopenia. Grade 3 anaemia, leukopenia, and neutropenia were more common in the paclitaxel-carboplatin group. The two groups’ nonhematological toxicities were nausea vomitus and hair loss, with peripheral neuropathy more experienced by the paclitaxel-carboplatin group. Costminimization analysis reveals that the average cost per patient with pulmonary adenocarcinoma negative EGFR mutation with paclitaxel-carboplatin regimen was cheaper IDR 10,986,257.55 or 50.25%, compared to pemetrexedcarboplatin. In conclusion, there was no significant difference in the effectiveness of the two regimens. The most common adverse effects in both regimens were haematological toxicities. The average cost per patient with a paclitaxel-carboplatin regimen was cheaper compared to pemetrexed-carboplatin.

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Journal articles on the topic 'Centre of Advanced Study in Sanskrit'

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