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Academic literature on the topic 'Cencer cells'

Author: Grafiati

Published: 6 September 2023

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Journal articles on the topic "Cencer cells"

1

Novikova, Inna Arnoldovna, Galina Nerodo, and Anna Iurievna Mordan. "Comparative analysis of DNA-cytometric indices of primary and relapsing ovarian cencer." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e16558-e16558. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e16558.

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e16558 Background: A ploidy of an average grade of aneuploidy cells and of proliferation index in ovarian tumor was studied. Methods: 21 patients with ovarian cancer of III-IV grades and 12 patients with acknowledged relapse of the disease aged from 46 to 67 to part in the research. We used CycleTEST PLUS DNA Reagent Kit (Becton Dickinson) for the analysis of DNA in the tumor’s tissues. Preparation of the tumor’s tissues was made with the use of disaggregating device BD Medimachine; after painting with propidium iodide (PI) we analyzed at flow cytofluorimeter BD Facs CantooII. Received data was processed with the help of computer program ModFit LT, allowing to analyze the ploidy and distribution of tumor’s cells according to phases of cellular cycle. Results: There was revealed the 2.5 times predominance of aneuploidy tumors over diploid in case of the relapse of the disease. The DNA index, different from 1.0, was registered in 83.3%, whereas there was noticed 33.3% primary ovarian tumors with aneuploidy content of DNA with predominance of diploidy tumors. There was noticed a tendency to the increase of aneuploidy cells during the relapse of the disease, where they made up 42.7±1.8%, whereas in primary ovarian tumors the share of aneuploidy cells was 40.4±1.6%. The index of proliferation of relapsing tumors was 1.8 times higher than this index of primary tumors, and made up 35.5±2.9 and 26.7±2.1 (p < 0.05). Conclusions: During the relapse of a tumor there is a predominance of aneuploidy tumors over diploid, the index of proliferation is higher in comparison with primary tumors.

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Wang, Huishan, Yan wen Liu, and Lin Miao. "Su2018 – Long Non-Coding Rna Zfas1 Promotes Proliferation of Colorectal Cencer Cells Via Upregulation Srebp1C to Promote De Novo Lipogenesis." Gastroenterology 156, no. 6 (May 2019): S—691—S—692. http://dx.doi.org/10.1016/s0016-5085(19)38650-0.

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Hamel, Keith M., Vladimir M. Liarski, and Marcus R. Clark. "Germinal Center B-cells." Autoimmunity 45, no. 5 (April 2, 2012): 333–47. http://dx.doi.org/10.3109/08916934.2012.665524.

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LANKHEET, MARTIN J. M., PETER LENNIE, and JOHN KRAUSKOPF. "Distinctive characteristics of subclasses of red–green P-cells in LGN of macaque." Visual Neuroscience 15, no. 1 (January 1998): 37–46. http://dx.doi.org/10.1017/s0952523898151027.

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We characterized the chromatic and temporal properties of a sample of 177 red–green parvocellular neurons in the LGN of Macaca nemestrina, using large-field stimuli modulated along different directions through a white point in color space. We examined differences among the properties of the four subclasses of red–green P-cells (on- and off-center, red and green center). The responses of off-center cells lag the stimulus more than do those of on-center cells. At low temporal frequencies, this causes the phase difference between responses of the two kinds of cells to be considerably less than 180 deg. For isoluminant modulations the phases of on- and off-responses were more nearly 180 deg apart. A cell's temporal characteristics did not depend on the class of cone driving its center. Red center and green center cells have characteristically different chromatic properties, expressed either as preferred elevations in color space, or as weights with which cells combine inputs from L- and M-cones. Red center cells are relatively more responsive to achromatic modulation, and attach relatively more weight to input from the cones driving the center. Off-center cells also attach relatively more weight than do on-center cells to input from the class of cone driving the center.

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Glover, Joel C. "From cartilage to cancer: Translational research at the Norwegian Center for Stem Cell Research." Cellular Therapy and Transplantation 4, no. 1-2 (2015): 66–68. http://dx.doi.org/10.18620/1866-8836-2015-4-1-2-66-68.

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Hurtley, Stella M., and Kristen L. Mueller. "Guiding immune cells to the center." Science 356, no. 6339 (May 18, 2017): 712.11–714. http://dx.doi.org/10.1126/science.356.6339.712-k.

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Zanetti, Maurizio. "Gating on germinal center B cells." Blood 110, no. 12 (December 1, 2007): 3816–17. http://dx.doi.org/10.1182/blood-2007-08-105502.

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Butch, A. W., G. H. Chung, J. W. Hoffmann, and M. H. Nahm. "Cytokine expression by germinal center cells." Journal of Immunology 150, no. 1 (January 1, 1993): 39–47. http://dx.doi.org/10.4049/jimmunol.150.1.39.

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Abstract Germinal centers (GC) primarily consist of B cells along with a small number of T cells (5 to 10%) and follicular dendritic cells (FDC) (< or = 1%). Although extensive Ag-driven B cell proliferation and maturation occurs in GC, very little is known about the role of cytokines in the development of GC B cells. Therefore, to identify cytokines present in the GC microenvironment that may influence B cell development, we systematically examined cytokine gene expression by GC cells. GC T cells (CD57+/CD4+), GC B cells (CD77+), and FDC (HJ2+) were isolated from human tonsils by cell sorting using a flow cytometer. Freshly isolated GC cells were examined for mRNA expression for IL-1 alpha, IL-1 beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, TNF-alpha, and IFN-gamma using reverse transcription polymerase chain reaction. Freshly isolated GC T cells consistently expressed IL-4 mRNA (11 of 12 tonsils), whereas CD57- Th cells (mostly non-GC Th cells) were often negative for IL-4 mRNA. When the other nine cytokine mRNA were studied, freshly isolated CD57+ Th cells occasionally expressed mRNA for IL-10, TNF-alpha, and IFN-gamma. CD57- Th cells were occasionally positive for IL-1 beta, IL-10, IFN-gamma, and TNF-alpha, and negative for IL-2 and IL-6. Freshly isolated GC B cells as well as FDC failed to express detectable quantities of mRNA for all 10 cytokines that were studied. Thus, IL-4 is the only cytokine out of 10 that is consistently expressed in GC and may be important for the development of B cells in GC. After stimulation of CD57+ Th cells with PWM, production of IL-4 mRNA was dramatically reduced, whereas CD57- Th cell production of IL-4 was greatly augmented. This finding indicates that GC T cells may differ from other Th cells in cytokine gene expression and that results of cytokine production obtained after in vitro stimulation do not always reflect in vivo results.

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Bowen, Mary B., Anthony W. Butch, Curtis A. Parvin, Alan Levine, and Moon H. Nahm. "Germinal center T cells are distinct helper-inducer T cells." Human Immunology 31, no. 1 (May 1991): 67–75. http://dx.doi.org/10.1016/0198-8859(91)90050-j.

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Norman, Helen. "Advice Center." Electric and Hybrid Rail Technology 2022, no. 1 (March 2022): 30–31. http://dx.doi.org/10.12968/s2754-7760(23)70037-6.

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Dissertations / Theses on the topic "Cencer cells"

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Dahlenborg, Katarina. "Celluar and molecular aspects of the germinal center reaction." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945013.html.

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Alexander, Carla-Maria Alana. "T regulatory cells and the germinal center." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1117.

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Germinal center (GC) reactions are central features of T cell-driven B cell responses, and the site where antibody (Ab) producing cells and memory B cells are generated. Within GCs, a range of complex cellular and molecular events occur which are critical for the generation of high affinity Abs. These processes require exquisite regulation not only to ensure the production of desired Abs, but to minimize unwanted autoreactive or low affinity Abs. To assess whether T regulatory cells (Treg) participate in the control of GC responses, immunized mice were treated with either an anti-glucocorticoid-induced TNFR-related protein (GITR) mAb or an anti-CD25 mAb to disrupt Treg activity. In both groups of treated mice, the GC B cell pool was significantly larger compared with control treated animals, with switched GC B cells composing an abnormally high proportion of the response. With these results indicating Tregs influence on GC dynamics, experiments were conducted to determine if Tregs were located in the GC, which subset of Treg was involved and by which mechanisms were their functions being effected. Within the spleens of immunized mice, CXCR5+ and CCR7- Tregs were documented by flow cytometry and Foxp3+ cells were found within GCs using immunohistology. Studies demonstrated administration of either anti-TGF-β or anti-IL-10R blocking mAb to likewise result in dysregulated GCs, suggesting that generation of inducible Tregs is important in controlling the GC response. Blockade of two Treg methods of suppression, PD-1/PD-L1 pathway and CTLA-4, also resulted in disrupted GCs, indicating the possible use of them for suppression by Treg. Collectively, these findings indicate that Tregs contribute to the overall size and quality of the humoral response by controlling homeostasis within GCs.

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Le, Thuc-vy L. "B cell clonal abundance and madcam-1 mediate affinity maturation and fate of germinal center B cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/le.pdf.

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Blink, Elizabeth J. "B cell selection in the germinal centre /." Connect to thesis, 2002. http://eprints.unimelb.edu.au/archive/00001459.

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Alexander, Lou-Ella M. m. "Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7119.

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The studies presented in this dissertation establish the dynamics of Eleven nineteen Lysine-rich leukemia (ELL) family of elongation factors during B cell differentiation and provide a description of ELL3 function in B cells. The transition from a mature naïve B cells into an activated B cell is dependent on a large increase in transcriptional output, which is followed by focused expression on secreted immunoglobulin upon terminal differentiation into plasma cell. While ELL family members have previously been implicated in alternative splicing at the immunoglobulin heavy chain locus in plasma cells, their presence and function prior to differentiation is currently not known. However, the use of elongation factors has been implied by the finding of mostly paused RNA polymerase II in the genome of naïve B cells. In the first study, the expression of transcriptional elongation factor ELL3 is shown to be restricted to activated B cells and B cell lymphomas. All three family members were characterized in B cell lymphoma cell lines, genome wide expression, microarray analysis and primary B cell stimulus. The expression of ELL3 was induced upon activation of B cells concurrently with family member ELL. In addition, the abundant expression of ELL3 was restricted to GC derived B cell lymphoma cell lines. While the expression of ELL is maintained, the expression of ELL3 is diminished and ELL2 is up-regulated in terminally differentiated plasma cells. The expression of master regulator of terminal plasma cell differentiation PRDM1 was inverse correlated with that of ELL3. To further establish PRDM1s role in regulating the ELL family member dynamics, global binding was assessed in plasma cell lines. Chromatin immunoprecipitation followed by quantitative PCR was utilized to identify direct association of PRDM1 at exclusively the ELL3 loci. Ectopic expression of PRDM1 in B cells down regulated the expression of ELL3. Furthermore, two consensus PRDM1 binding sites were defined at the ELL3 loci, which mediate significant repression of the promoter activity. Collectively, these experiments indicate that PRDM1 mediates the switch from ELL3 in B cells to ELL2 in plasma cells. The data presented in the final chapter aimed at defining a function for ELL3 in the cells that express it most abundantly, which are B cell lymphoma cell lines. Transient depletion of ELL3 in a Burkitt’s lymphoma cell line resulted in a diminished proliferation rate due to a severe disruption of DNA replication and its regulators minichromosome maintenance proteins. Additionally, compromised cell division and mitotic regulators were observed along with increased DNA damage and cell death. The data presented here demonstrate a key role for ELL3 in the proliferation and survival of B cell lymphomas and positions ELL3 as an attractive therapeutic target against B cell lymphoma’s with a germinal center origin.

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Yaghoubi, Houman. "Bio-Photoelectrochemical Solar Cells Incorporating Reaction Center and Reaction Center Plus Light Harvesting Complexes." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5803.

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Harvesting solar energy can potentially be a promising solution to the energy crisis now and in the future. However, material and processing costs continue to be the most important limitations for the commercial devices. A key solution to these problems might lie within the development of bio-hybrid solar cells that seeks to mimic photosynthesis to harvest solar energy and to take advantage of the low material costs, negative carbon footprint, and material abundance. The bio-photoelectrochemical cell technologies exploit biomimetic means of energy conversion by utilizing plant-derived photosystems which can be inexpensive and ultimately the most sustainable alternative. Plants and photosynthetic bacteria harvest light, through special proteins called reaction centers (RCs), with high efficiency and convert it into electrochemical energy. In theory, photosynthetic RCs can be used in a device to harvest solar energy and generate 1.1 V open circuit voltage and ~1 mA cm-2 short circuit photocurrent. Considering the nearly perfect quantum yield of photo-induced charge separation, efficiency of a protein-based solar cell might exceed 20%. In practice, the efficiency of fabricated devices has been limited mainly due to the challenges in the electron transfer between the protein complex and the device electrodes as well as limited light absorption. The overarching goal of this work is to increase the power conversion efficiency in protein-based solar cells by addressing those issues (i.e. electron transfer and light absorption). This work presents several approaches to increase the charge transfer rate between the photosynthetic RC and underlying electrode as well as increasing the light absorption to eventually enhance the external quantum efficiency (EQE) of bio-hybrid solar cells. The first approach is to decrease the electron transfer distance between one of the redox active sites in the RC and the underlying electrode by direct attachment of the of protein complex onto Au electrodes via surface exposed cysteine residues. This resulted in photocurrent densities as large as ~600 nA cm-2 while still the incident photon to generated electron quantum efficiency was as low as %3 × 10-4. 2- The second approach is to immobilize wild type RCs of Rhodobacter sphaeroides on the surface of a Au underlying electrode using self-assembled monolayers of carboxylic acid terminated oligomers and cytochrome c charge mediating layers, with a preferential orientation from the primary electron donor site. This approach resulted in EQE of up to 0.06%, which showed 200 times efficiency improvement comparing to the first approach. In the third approach, instead of isolated protein complexes, RCs plus light harvesting (LH) complexes were employed for a better photon absorption. Direct attachment of RC-LH1 complexes on Au working electrodes, resulted in 0.21% EQE which showed 3.5 times efficiency improvement over the second approach (700 times higher than the first approach). The main impact of this work is the harnessing of biological RCs for efficient energy harvesting in man-made structures. Specifically, the results in this work will advance the application of RCs in devices for energy harvesting and will enable a better understanding of bio and nanomaterial interfaces, thereby advancing the application of biological materials in electronic devices. At the end, this work offers general guidelines that can serve to improve the performance of bio-hybrid solar cells.

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Hung, Hui-Fang. "Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/842.

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Epithelial cells are necessary building blocks of the organs they line. Their apicalbasolateral polarity, characterized by an asymmetric distribution of cell components along their apical-basal axis, is a requirement for normal organ function. Although the centrosome, also known as the microtubule organizing center, is important in establishing cell polarity the mechanisms through which it achieves this remain unclear. It has been suggested that the centrosome influences cell polarity through microtubule cytoskeleton organization and endosome trafficking. In the first chapter of this thesis, I summarize the current understanding of the mechanisms regulating cell polarity and review evidence for the role of centrosomes in this process. In the second chapter, I examine the roles of the mother centriole appendages in cell polarity during cell migration and cell division. Interestingly, the subdistal appendages, but not the distal appendages, are essential in both processes, a role they achieve through organizing centrosomal microtubules. Depletion of subdistal appendages disrupts microtubule organization at the centrosome and hence, affects microtubule stability. These microtubule defects affect centrosome reorientation and spindle orientation during cell migration and division, respectively. In addition, depletion of subdistal appendages affects the localization and dynamics of apical polarity proteins in relation to microtubule stability and endosome recycling. Taken together, our results suggest the mother centriole subdistal appendages play an essential role in regulating cell polarity. A discussion of the significance of these results is included in chapter three.

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Hung, Hui-Fang. "Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/842.

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Epithelial cells are necessary building blocks of the organs they line. Their apicalbasolateral polarity, characterized by an asymmetric distribution of cell components along their apical-basal axis, is a requirement for normal organ function. Although the centrosome, also known as the microtubule organizing center, is important in establishing cell polarity the mechanisms through which it achieves this remain unclear. It has been suggested that the centrosome influences cell polarity through microtubule cytoskeleton organization and endosome trafficking. In the first chapter of this thesis, I summarize the current understanding of the mechanisms regulating cell polarity and review evidence for the role of centrosomes in this process. In the second chapter, I examine the roles of the mother centriole appendages in cell polarity during cell migration and cell division. Interestingly, the subdistal appendages, but not the distal appendages, are essential in both processes, a role they achieve through organizing centrosomal microtubules. Depletion of subdistal appendages disrupts microtubule organization at the centrosome and hence, affects microtubule stability. These microtubule defects affect centrosome reorientation and spindle orientation during cell migration and division, respectively. In addition, depletion of subdistal appendages affects the localization and dynamics of apical polarity proteins in relation to microtubule stability and endosome recycling. Taken together, our results suggest the mother centriole subdistal appendages play an essential role in regulating cell polarity. A discussion of the significance of these results is included in chapter three.

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Eijk, Martinus Cornelis van. "Regulation of germinal center B cell apoptosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/83857.

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Gimpel, Petra. "Mechanisms of non-centrosomal MTOC formation at the nucleus in muscle cells." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066442/document.

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Le juste positionnement du noyau durant la formation musculaire semble important pour la fonction musculaire et des défauts ont été associés à plusieurs maladies musculaires. Le positionnement nucléaire dépend des microtubules (MTs), qui sont réorganisés depuis le centrosome, dans les myoblastes proliférants, vers l’enveloppe nucléaire (EN), dans les myotubes différenciés. Cette réorganisation s'accompagne de la redistribution des protéines centrosomales vers l’EN qui adopte le rôle de centre organisateur des microtubules (MTOC) lors de la différenciation myogénique. Néanmoins, les mécanismes sous-jacents restent inconnus. Ici, nous avons identifié les protéines Nesprin-1 et Sun1/2, localisées respectivement à la membrane nucléaire externe et interne, comme impliquées dans le recrutement de la fonction MTOC à l’EN. Les cellules déficientes en Nesprin-1 ou Sun1/2 ont montré une localisation altérée des protéines centrosomales dans le cytoplasme et l’absence des MTs depuis l’EN. De plus, Nesprin-1alpha, une myo-isoforme de Nesprin-1, s’associait aux protéines centrosomales Akap450, Pericentrin et Pcm1 dans les myotubes C2C12 et était suffisante pour corriger les défauts observés dans des cellules déplétées en Nesprin-1. Parmi les protéines centrosomales recrutées par Nesprin-1alpha, seule Akap450 semble nécessaire à la nucléation des MTs à l’EN. Ce processus, médié par Akap450 et Nesprin-1alpha, s’est avéré important pour le positionnement nucléaire lors du développement des myotubes. Ces résultats renforcent notre compréhension sur le lien causal entre des défauts lors de la formation du MTOC à l’EN et des défauts de positionnement nucléaire dans les dystrophies musculaires
The accurate position of the nucleus during skeletal muscle formation seems to be important for muscle function, and defects have been associated with numerous muscle diseases. Nuclear positioning requires microtubules (MTs) which are reorganized from the centrosome in proliferating myoblasts to the nuclear envelope (NE) in differentiated myotubes. This dramatic MT reorganization is accompanied by a redistribution of proteins from the centrosome to the NE which thus takes over the function as a microtubule-organizing center (MTOC) during myogenic differentiation. However, the underlying mechanisms are still unknown. Here, we identified Nesprin-1 and Sun1/2, outer and inner nuclear membrane proteins, respectively, to be involved in the recruitment of MTOC function to the NE. Nesprin-1 or Sun1/2 deficient cells displayed mislocalization of centrosomal proteins to the cytoplasm and failed to regrow MTs from the NE. Moreover, the muscle-specific isoform of Nesprin-1, namely Nesprin-1alpha, was shown to be highly associated with the centrosomal proteins Akap450, Pericentrin and Pcm1 in C2C12 myotubes and to be sufficient to rescue the observed defects in Nesprin-1 depleted cells. Among the centrosomal proteins localizing at the NE during myogenic differentiation, solely Akap450 seemed to be required for MT nucleation. Akap450-Nesprin-1alpha-mediated MT nucleation from the NE was demonstrated to play an important role in nuclear positioning during myotube formation. These findings strengthen our understanding on how defects in MTOC formation at the NE can link to nuclear positioning defects in muscular dystrophies

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Books on the topic "Cencer cells"

1

A, Khairallah Edward, Bond Judith S, and Bird John W. C, eds. Intracellular protein catabolism: Proceedings of the Fifth International Symposium on Intracellular Protein Catabolism, held May 29-June 2, 1984, at the Airlie Conference Center, Airlie, Virginia. New York: A.R. Liss, 1985.

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Administration, United States National Aeronautics and Space. Space Photovoltaic Research and Technology-1989: Proceedings of a conference held at NASA Lewis Research Center, Cleveland, Ohio, November 7-9, 1989. Cleveland, Ohio: Lewis Research Center, 1991.

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Center, Lewis Research. Space Photovoltaic Research and Technology 1988: High efficiency, space environment, and array technology : proceedings of a conference held at NASA Lewis Research Center, Cleveland, Ohio, April 19-21, 1988. Cleveland, Ohio: Lewis Research Center, 1989.

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Italy) International Meeting on Lithium Batteries (10th 2000 Como. 10th International Meeting on Lithium Batteries: Lithium 2000, Villa Erba Conference Center, Como, Italy, May 28-June 2, 2000, IMLB. Pennington, N.J: Electrochemical Society, 2000.

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Center, Lewis Research. Space Photovoltaic Research and Technology 1995: Proceedings of the SPRAT XIV Conference held at and sponsored by NASA Lewis Research Center, Cleveland, Ohio, October 24-26, 1995. Cleveland, Ohio: Lewis Research Center, 1996.

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Bei-Jiann, Chang, and NASA Glenn Research Center, eds. Regenerative fuel cell test rig at Glenn Research Center. [Cleveland, Ohio]: National Aeronautics and Space Administration, Glenn Research Center, 2003.

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Kjell, Fuxe, and Agnati Luigi Francesca, eds. Receptor-receptor interactions: A new intramembrane integrative mechanism : proceedings of an international symposium held at the Wenner-Gren Center, Stockholm, October 9th-11th, 1986. New York: Plenum Press, 1987.

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Center, Lewis Research. Space Electrochemical Research and Technology: Proceedings of a conference held at NASA Lewis Research Center, April 9-10, 1991. Cleveland, Ohio: Lewis Research Center, 1991.

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1957-, Ang Simon S., Brown W. D, and United States. National Aeronautics and Space Administration., eds. Study of Staebler-Wronski degradation effect in a-Si:H based p-i-n solar cells: Final report submitted to NASA/Lewis Research Center. Fayetteville, Ark: Dept. of Electrical Engineering, University of Arkansas, 1993.

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1957-, Ang Simon S., Brown W. D, and United States. National Aeronautics and Space Administration., eds. Study of Staebler-Wronski degradation effect in a-Si:H based p-i-n solar cells: Final report submitted to NASA/Lewis Research Center. Fayetteville, Ark: Dept. of Electrical Engineering, University of Arkansas, 1993.

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Book chapters on the topic "Cencer cells"

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Valberg, Arne. "Ganglion Cells, On-Center Ganglion Cells, Off-Center Ganglion Cells, Midget Ganglion, Diffuse Ganglion Cells." In Encyclopedia of Color Science and Technology, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27851-8_276-1.

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Wu, Ian Qianhuang, Francesca Lorraine Wei Inng Lim, and Liang Piu Koh. "Outpatient Care." In The Comprehensive Cancer Center, 21–33. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82052-7_4.

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AbstractManagement of haematology-oncology patients has historically been largely inpatient-based. With advances in the understanding of disease and improvements in supportive care, patients are increasingly being managed in the outpatient setting. This is especially evident in autologous stem cell transplantation, which is now routinely done as an outpatient procedure at various centres. As clinicians gain more experience in novel therapies such as chimeric antigen receptor (CAR)-T cell therapy and bispecific T cell engager (BiTE) therapy, these may potentially be administered in the outpatient setting in the near future with the adoption of a risk-stratified approach. Such a paradigm shift in the practice of haematology-oncology is inevitable and has been driven by several factors, including pressure from the institution/hospital to avoid unnecessary hospital admissions and for optimal use of inpatient resources to be more cost-effective and efficient. With favourable local regulations and funding, outpatient cancer care can be economically beneficial. The success of an outpatient cancer center is heavily dependent on planning the facility to be equipped with the appropriate infrastructure, together with the trained medical and supportive personnel in place. This, coupled with the utilization of emerging technology such as telemedicine, has the potential to revolutionize cancer care delivery in the outpatient setting.

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Majhail, Navneet S., and Marcos De Lima. "Transplantation and Cellular Therapy." In The Comprehensive Cancer Center, 121–33. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82052-7_13.

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AbstractComprehensive cancer services include provision of care to patients with advanced hematologic malignancies, among whom some patients are candidates for hematopoietic cell transplantation (HCT). HCT is a complex and resource-intense medical procedure and optimal transplant outcomes require a high-functioning, multidisciplinary, and cohesive team. The presence of a successful HCT program reflects the commitment from a cancer center to provide comprehensive cancer care services. The program can also serve as a platform for performing cellular therapy procedures such as chimeric antigen receptor T-cell therapies. This chapter reviews the potential pathways to establish an HCT and cellular therapy program along with recommendations on the required infrastructure and personnel. In addition, the chapter provides the foundation for establishing a robust quality program and the resources required for data and research.

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Subtil, Antonio. "Extrafollicular Localization of Germinal Center Cells." In Diagnosis of Cutaneous Lymphoid Infiltrates, 23–25. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11654-5_6.

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Casamayor-Palleja, M., A. Gulbranson-Judge, and I. C. M. MacLennan. "T Cells in the Selection of Germinal Center B Cells." In Chemical Immunology and Allergy, 27–44. Basel: KARGER, 1997. http://dx.doi.org/10.1159/000058676.

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Brown, A. N., and H. N. A. Willcox. "Enrichment of Germinal Centre Cells." In Advances in Experimental Medicine and Biology, 227–32. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5535-9_34.

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Riexinger, Günther, David J. Regina, Christoph Haar, Tobias Schmid-Schirling, Inga Landwehr, Michael Seib, Jonas Lips, et al. "Traceability in Battery Production: Cell-Specific Marker-Free Identification of Electrode Segments." In Advances in Automotive Production Technology – Towards Software-Defined Manufacturing and Resilient Supply Chains, 344–53. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-27933-1_32.

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AbstractDigitalization in battery production, as well as the increase and stabilization of product quality of lithium-ion battery cells, require the elimination of information gaps between processes to enable the traceability of components and process steps to the finished product. In lithium-ion battery cell manufacturing, using a traceability system is considered a promising approach to reduce scrap rates and enable more efficient production. Today, traceability is possible from the assembled cell onwards. However, with a view to the new EU battery regulation, complete traceability down to the material needs to be ensured. One of the challenges in this context is to ensure both, traceability in continuous electrode production and cell-specific identification within the production chain. This paper presents an approach for identifying individual electrode segments without identification markers, using the individual microstructure of the electrode surface. The Fraunhofer Institute for Manufacturing Engineering and Automation IPA and the Fraunhofer Institute for Physical Measurement Techniques IPM are further developing and testing an identification technique known as Track & Trace Fingerprint. This technique is dedicated to serialization within battery production as part of the joint project DigiBattPro 4.0 and to be implemented at the Center for Digitalized Battery Cell Manufacturing (ZDB) of Fraunhofer IPA.

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Pattengale, Paul K. "Follicular Center Cell Lymphoma, Mouse." In Hemopoietic System, 147–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-84110-1_23.

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Peters, Nils, Martin Dichgans, Sankar Surendran, Josep M. Argilés, Francisco J. López-Soriano, Sílvia Busquets, Klaus Dittmann, et al. "Cutaneous Follicle Center Cell Lymphoma." In Encyclopedia of Molecular Mechanisms of Disease, 476–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8262.

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Ferrero, Domenico, Andrea Lanzini, and Massimo Santarelli. "Solid Oxide Fuel Cells Modeling." In CISM International Centre for Mechanical Sciences, 291–342. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46146-5_8.

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Conference papers on the topic "Cencer cells"

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Rios-Colon, Leslimar, Anamika Basu, Catherine Elix, Carlos A. Casiano, and Marino De León. "Abstract 892: The stress oncoprotein LEDGF/P75 promotes selective resistance to multiple chemotherapeutic drugs in prostate cencer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-892.

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Smith, Vivianne C., Joel Pokorny, Barry B. Lee, Paul R. Martin, and Arne Valberg. "Cone inputs to macaque M-pathway (phasic) retinal ganglion cells." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.thv6.

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At ARVO 1989 we presented amplitude and phase data for macaque retinal ganglion cells to a temporal stimulus. Our stimulus presented 2000-td equiluminant red and green LEDs in temporal sine wave modulation. We measured ganglion cell responses as a function of physical phase difference between the LEDs. P-pathway (tonic) cells could be described by a linear model of the LWS and MWS cone inputs. M-pathway (phasic) cell behavior was more complicated. Phasic ON- and OFF-center cells showed similar amplitude behavior as a function of physical phase angle that paralleled psychophysical data for the same stimulus. The data suggested evidence of compound center-surround inputs: centers show (LWS + MWS) cone summation while surrounds show cone opponency and can be Red-On or Green-On. The phasic cells showed differing phase patterns. Some phasic cells showed a phase response dominated by L cones while others showed evidence of a phasic response dominated by M cones, giving four different phase patterns: ON-center with LWS cone phase, OFF-center with MWS cone phase, ON-center with MWS cone phase and OFF-center with LWS cone phase. The first two could be fit by an (LWS + MWS) center with an opponent surround that showed a fixed 90° phase shift, predicted by the quadrature nature of the stimulus. The other pair of phasic cells could also be predicted by a (LWS + MWS) center and an opponent surround. However, the surround phase was 180° with respect to the center. All cells show a small center-surround latency.

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De Valois, Russell L. "Encoding of spatial frequency, orientation, and contrast in striate cortex." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1985. http://dx.doi.org/10.1364/oam.1985.thr1.

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Electrophysiological and anatomical evidence from monkeys indicates that the striate cortex is broken up into some 1500 modules, each containing cells which process information from a limited part of the visual field which overlaps to a varying extent (depending on the cell’s peak spatial frequency) with the cells in neighboring modules. Within each module is a systematic columnar arrangement of cells tuned to various 2-D spatial frequency regions (orientation and spatial frequency). The various cells within a foveally related module cover at least a 5-octave spatial frequency range. With increasing eccentricity, the center of the band shifts to lower spatial frequencies, and the octave range may also narrow. The narrowly tuned simple cells within each module have multiple, mutually antagonistic subregions within their receptive fields and an overall rf shape which approximates a 2-D Gabor (a sinusoid tapered in x and y by a Gaussian). Each narrowly tuned simple and complex cell is optimally activated by patterns containing power within its particular 2-D spatial frequency region in its particular limited part of the visual field; the simple cells are also selective for the phase of the pattern, but the complex cells are not.

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Lennie, Peter, P. William Haake, and David R. Williams. "Chromatic opponency through indiscriminate connections to cones." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.thv3.

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A midget (P) ganglion cell in or close to the macaque's fovea has a receptive field in which the center is probably driven by a single cone. Thus, even if the surround drew indiscriminately on signals from all classes of cone, such a receptive field would be chromatically opponent. We have used a computer simulation to analyze the chromatic properties of P-cells with receptive fields constructed by drawing on a mosaic of R, G, and B cones, and allowing single or multiple cones to contribute to the center, without selection of the classes of cones that contribute to center and surround. For each synthetic cell we calculated the spectral sensitivity and also the weights that it attached to signals from the different classes of cone, and we compared the distribution of weights obtained from a population of such cells with the distribution obtained by Derrington, Krauskopf, and Lennie [J. Physiol. 357, 241 (1984)] in their analysis of the chromatic properties of P-cells in LGN.

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Nix, Stephanie, Yohsuke Imai, Daiki Matsunaga, Takuji Ishikawa, and Takami Yamaguchi. "Dynamics of a Spherical Capsule in a Near-Wall Shear Flow." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80518.

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Lateral migration of cells in the bloodstream is affected by the material properties of the constituent cells. In blood vessels, red blood cells migrate to the center of the vessel, leading to the formation of a cell-free layer near the vessel wall; on the other hand, less deformable cells such as white blood cells and platelets are more likely to be found near the blood vessel wall. [1]

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Croitoru, N., M. Zafrir, S. Amirhaghi, and Z. Harzion. "Schottky-type photovoltaic junctions with transparent conductor films." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1985. http://dx.doi.org/10.1364/oam.1985.fr6.

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Junctions between transparent conductor (ITO) and single-crystal silicon or polycrystalline silicon (poly-Si) were prepared. Electrical I–V and C-V, as well as photovoltage decay (PVD) measurements, were performed. Data of open circuit voltage (Voc), short circuit current (Isc), fill factor (FF), efficiency (η), built-in potential (ϕ- bl ), and lifetime were obtained. It was found that the lifetime of photogenerated carriers in the poly-Si/ITO junction is much shorter than in single crystal. There are two types of recombination center that have an essential influence on the efficiency of the solar cells; those at the contact between ITO and the silicon; and those due to the grain boundaries (GB) between the crystallites in poly-Si. The solar cells were annealed, either by heating them in vacuum or by irradiation with the light of a Cd–Ne laser (441.6 nm). The annealing reduced the influence of the recombination centers at the contact, whereas those at the GB were not affected. Passivation of GB with iodine improved the characteristics of the solar cells. This improvement is attributed to the reduction of the recombination centers at GB. The influence of the annealing and passivation on the lifetime of this type of cell was studied by measuring PVD.

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Parker, Kevin Kit, and Donald E. Ingber. "Cell Motility in Microfabricated Models of the Tissue Microenvironment." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23075.

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Abstract We conducted studies using micropatterned substrates to elucidate how cell shape and geometric confinement regulates the inter- and intracellular signaling pathways required for cell motility. When cells were cultured on individual cell-sized square adhesive islands coated with ECM, they extend to the edge of the island and assume a square shape. When these cells were stimulated with growth factors, they preferentially extended lamellipodia from the corners versus the sides. This process was mediated by myosin-generated isometric tension that induced tight spatial localization of Rac in the corners. When two or three capillary endothelial cells are constrained to a fibronectin (FN) island, coordinated cell migration results in stable rotation of the entire system about its center. Thus, the emergent pattern is due to the coordinated migration behavior of the cells. These observations suggest that ECM-induced mechanotransduction potentiates compartmentalized signaling pathways and the multicellular organization required of tissue morphogenesis.

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Lee, B. B., J. M. Crook, and A. Valberg. "Thresholds of monkey LGN cells to chromatic spots on a white background." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1985. http://dx.doi.org/10.1364/oam.1985.wu8.

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Measurements of psychophysical thresholds to chromatic spots presented on a white background purport to demonstrate the existence of chromatic and luminance channels. We measured thresholds to such stimuli of the phasic, magnocellular (MCL) and the tonic, wavelength-opponent parvocellular (POL), cells of the macaque lateral geniculate nucleus. Spectral sensitivity of MCL cells approximated the V function. Wtih 4° spots, blue on-center and red on-center PCL cells were the most sensitive at the spectral ends, while in midspectrum MCL cells were somewhat more sensitive than the most sensitive PCL cells; with achromatic stimuli MCL cells were substantially more sensitive than PCL cells. With small spots, sensitivity of the different opponent cells decreased substantially at the spectral ends to become close to or slightly higher than that of MCL cells. Psychophysical thresholds with human subjects at similar retinal eccentricities with similar spot sizes could be accounted for by assuming the most sensitive cells were responsible for detection, supporting the notion that different cell classes support detection in different stimulus conditions.

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Redler, Adam, Shawn Paul, and Charles Berry. "The Role of Remote Monitoring in Promoting Increased Adoption of Mission Critical Fuel Cells." In ASME 2010 8th International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2010. http://dx.doi.org/10.1115/fuelcell2010-33087.

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Fuel cells are seen by the general public as a new and potentially risky energy source, despite their long history of reliable operation. Fuel cells have been applied in critical applications since their deployment in NASA’s Gemini missions in the mid-1960’s. They are still being used in today’s space shuttles to provide electrical power and drinking water. Over the past decade hundreds of stationary systems have been installed in commercial applications for primary, backup and supplemental power. To promote a better understanding of the benefits of fuel cells, a wider dissemination of real world performance data is needed to show the efficiency, reliability and economic reality of fuel cells. Fuel cell performance is of special interest to the mission critical data center industry, which is slowly considering blending conventional and alternative power sources. Fuel cells are a cleaner and more efficient alternative to grid-supplied electricity in addition to being a viable alternative to batteries and diesel generators for backup power. In areas with poor grid reliability or other power quality issues, fuel cells can be used as the primary power source to provide high quality prime power while the grid provides backup and supplemental power. Waste heat from the fuel cells may be captured and used for space heating or hot water production, or used in absorption chillers to provide air-conditioning for server rooms. With a well-designed heat recovery system, the overall combined heat and power efficiency of a fuel cell installation can approach 90%. This paper will discuss the implementation and applications of the web-based fuel cell monitoring system currently being deployed across Connecticut to promote fuel cell technology awareness and highlight their economic benefits. This monitoring system is being used as a proof-of-concept demonstration that is expected to drive technology adoption in the very competitive and critical private sector data center industry. The monitoring system is already providing publicly accessible data on fuel cell performance via the Internet, and can be used to analyze real-world fuel cell performance data from a wide variety of applications as the system is expanded across the state.

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Shiraishi, Toshihiko, Takafumi Onishi, Shin Morishita, and Ryohei Takeuchi. "Measurement of Dynamic Viscoelasticity of an Osteoblast Under Adhesive Condition Using a Piezoelectric Vibrator." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67235.

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Bone cells are adaptive to surrounding mechanical conditions. Osteoblasts, one of bone cells, have been reported to be sensible to mechanical stimulation and change the generated bone mass. Viscoelastic properties of such cells are predicted to be related to this phenomenon in the view of mechanical dynamics. In order to find the effective stimulation on the bone formation, it is necessary to understand the viscoelastic properties of the cells. Especially in the case of bone cells, it is important to consider their adhesive condition because they attach on surfaces of bone matrices. In this study, we measured dynamic viscoelastic properties of a cultured osteoblast, MC3T3-E1, under adhesive condition. Using the experimental results, we derived a model for viscoelasticity of the cell and identified the value of each element in this model. The cells were seeded on a glass plate in a petri dish. After the cells were cultured for one day and adhered on the glass plate, it was vertically raised and fixed on a piezo actuator. The center of the cell surface was aspirated with an L-shaped micropipette to be held. The glass plate was moved with the piezo actuator. The load applied to the cell was obtained by measuring the deflection of the micropipette whose spring constant was calibrated after each test. Deflection of the micropipette and elongation of the cell were measured by captured image during the test. As a result, the dynamic viscoelasticity of the cells was measured and modeled, and the value of each element in this model was identified.

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Reports on the topic "Cencer cells"

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Santurri, P. R. ,., C. Hartmann-Thompson, and S. E. Keinath. Center for Intelligent Fuel Cell Materials Design. Office of Scientific and Technical Information (OSTI), August 2008. http://dx.doi.org/10.2172/944938.

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Bailey, Sharon A., Carl P. Baker, O. Dennis Mullen, and Patrick LJ Valdez. Solid Waste Processing Center Primary Opening Cells Systems, Equipment and Tools. Office of Scientific and Technical Information (OSTI), April 2006. http://dx.doi.org/10.2172/881692.

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Eshed-Williams, Leor, and Daniel Zilberman. Genetic and cellular networks regulating cell fate at the shoot apical meristem. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7699862.bard.

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The shoot apical meristem establishes plant architecture by continuously producing new lateral organs such as leaves, axillary meristems and flowers throughout the plant life cycle. This unique capacity is achieved by a group of self-renewing pluripotent stem cells that give rise to founder cells, which can differentiate into multiple cell and tissue types in response to environmental and developmental cues. Cell fate specification at the shoot apical meristem is programmed primarily by transcription factors acting in a complex gene regulatory network. In this project we proposed to provide significant understanding of meristem maintenance and cell fate specification by studying four transcription factors acting at the meristem. Our original aim was to identify the direct target genes of WUS, STM, KNAT6 and CNA transcription factor in a genome wide scale and the manner by which they regulate their targets. Our goal was to integrate this data into a regulatory model of cell fate specification in the SAM and to identify key genes within the model for further study. We have generated transgenic plants carrying the four TF with two different tags and preformed chromatin Immunoprecipitation (ChIP) assay to identify the TF direct target genes. Due to unforeseen obstacles we have been delayed in achieving this aim but hope to accomplish it soon. Using the GR inducible system, genetic approach and transcriptome analysis [mRNA-seq] we provided a new look at meristem activity and its regulation of morphogenesis and phyllotaxy and propose a coherent framework for the role of many factors acting in meristem development and maintenance. We provided evidence for 3 different mechanisms for the regulation of WUS expression, DNA methylation, a second receptor pathway - the ERECTA receptor and the CNA TF that negatively regulates WUS expression in its own domain, the Organizing Center. We found that once the WUS expression level surpasses a certain threshold it alters cell identity at the periphery of the inflorescence meristem from floral meristem to carpel fate [FM]. When WUS expression highly elevated in the FM, the meristem turn into indeterminate. We showed that WUS activate cytokinine, inhibit auxin response and represses the genes required for root identity fate and that gradual increase in WUCHEL activity leads to gradual meristem enlargement that affect phyllotaxis. We also propose a model in which the direction of WUS domain expansion laterally or upward affects meristem structure differently. We preformed mRNA-seq on meristems with different size and structure followed by k-means clustering and identified groups of genes that are expressed in specific domains at the meristem. We will integrate this data with the ChIP-seq of the 4 TF to add another layer to the genetic network regulating meristem activity.

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Saur, Genevieve, Vanessa Arjona, Amberlie Clutterbuck, and Eric Parker. Hydrogen and Fuel Cells for Data Center Applications Project Meeting: Workshop Report. Office of Scientific and Technical Information (OSTI), December 2019. http://dx.doi.org/10.2172/1578270.

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Nelson, Douglas. GATE Center for Automotive Fuel Cell Systems at Virginia Tech. Office of Scientific and Technical Information (OSTI), September 2011. http://dx.doi.org/10.2172/1053591.

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William W. Glauz. MOLTEN CARBONATE FUEL CELL POWER PLANT LOCATED AT LADWP MAIN STREET SERVICE CENTER. Office of Scientific and Technical Information (OSTI), September 2004. http://dx.doi.org/10.2172/835953.

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Erickson, Paul. UC Davis Fuel Cell, Hydrogen, and Hybrid Vehicle (FCH2V) GATE Center of Excellence. Office of Scientific and Technical Information (OSTI), May 2012. http://dx.doi.org/10.2172/1055762.

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Berry, JB. Fuel Cell Demonstration Project - 200 kW - Phosphoric Acid Fuel Cell Power Plant Located at the National Transportation Research Center: FINAL REPORT. Office of Scientific and Technical Information (OSTI), May 2005. http://dx.doi.org/10.2172/885957.

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Binder, Michael J., Franklin H. Holcomb, and William R. Taylor. Site Evaluation for Application of Fuel Cell Technology, Naval Education Training Center, Newport, RI. Fort Belvoir, VA: Defense Technical Information Center, February 2001. http://dx.doi.org/10.21236/ada389613.

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Binder, Michael J., Franklin H. Holcomb, and William R. Taylor. Site Evaluation for Application of Fuel Cell Technology, Construction Battalion Center, Port Hueneme, CA. Fort Belvoir, VA: Defense Technical Information Center, February 2001. http://dx.doi.org/10.21236/ada389909.

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