Dissertations / Theses on the topic 'Cellular differentiation'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Cellular differentiation.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Glover, Beverley Jane. "Cellular differentiation in plants." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338247.
Full textBrero, Alessandro. "Nuclear topology during cellular differentiation in mouse." Diss., [S.l.] : [s.n.], 2004. http://edoc.ub.uni-muenchen.de/archive/00002625/.
Full textLeahy, Rachel A. "Signal Transduction and Cellular Differentiation in Airway Epithelium." Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1352673026.
Full textYu, Lu. "Multiple signaling pathways cooperate to activate skeletal muscle differentiation /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BICH%202005%20YU.
Full textChano, Laura. "Emdogain regulation of cellular differentiation in wounded rat periodontium." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63000.pdf.
Full textParker, Emma. "The role of insulin-like growth factor binding proteins (IGFBPs) in the pathogenesis of pulmonary fibrosis." Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269130.
Full textClarke, A. R. "Retroviral mediated expression of B-galactosidase in mouse cells." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303267.
Full textDixon, Katherine. "Characterization of the Global and Locus-Specific Regulation of Gene Expression During Early Myogenic Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35079.
Full textBerg, Tove. "C/EBP transcription factors in lung cellular differentiation and development /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-586-0/.
Full textMunkley, Jennifer. "The sub-cellular organisation of DNA replication factors during differentiation." Thesis, University of York, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547361.
Full textCowan, Joanne L. "Translational control during cellular stress and differentiation of C2C12 myoblasts." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436824.
Full textMidgley, Adam Christopher. "Cellular mechanisms of myofibroblast differentiation and dysfunctions in wound healing." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/59241/.
Full textNguyen, Khoi Thien. "Epigenetic determinants of cellular differentiation, transcriptional reprogramming, and human disease." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130186.
Full textCataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 111-130).
Much of the diversity we observe in cellular and organismal phenotypes can be attributed to epigenetic and genetic variation. DNA provides the instructions for life, while epigenetic modifications regulate which parts of the genetic information contained in DNA can be read out in a given cell and how this information is interpreted. In recent years, epigenetic and genetic variation has been profiled on a large scale with sequencing-based assays, generating many datasets to be explored. In this thesis, I present three projects which apply computational techniques to identify and characterize epigenetic mechanisms that may contribute to the regulation of phenotypic variance. First, we mine a dataset charactering the epigenomes of diverse cell types in order to discover signatures of adult stem cell differentiation.
We identify a novel marker of the multipotent state, a chromatin state characterized by the histone marks H3K36me3 and H3K9me3, and describe biological processes that may be linked to the loss of this chromatin state in fully differentiated cell types. Next, I present what we learned from profiling the epigenetic state of cells before and after transplantation into Xenopus oocytes, a process that transcriptionally reprograms the cells. This analysis elucidates how the initial epigenetic state of a cell influences the success of cellular reprogramming and identifies transcription factors that help regulate this process. Finally, we integrate studies measuring the effects of genetic variants on disease with studies measuring the effects of genetic variants on transcriptional and epigenetic activity. This identifies specific mechanisms underlying disease processes, and demonstrates that transcriptional and epigenetic mechanisms may independently contribute to disease pathogenesis.
Together, these projects demonstrate the biological insights that can be gained from epigenetic profiling, and expand our understanding of the potential effects of epigenetic modifications.
by Khoi Thien Nguyen.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biological Engineering
Thulabandu, Venkata Revanth Sai Kumar. "REGULATION OF CELLULAR DIFFERENTIATION BY EZH2 DURING SKIN ANDMUSCLE DEVELOPMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1623415890187889.
Full textHerron, Matthew David. "Evolution of Multicellularity and Cellular Differentiation in the Volvocine Algae." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/196054.
Full textHung, Hiu Wai. "Signal transduction mechanism in xenopus presynaptic differentiation /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20HUNG.
Full textWang, Kepeng. "The involvement of JAK2/STAT2/STAT3 in myogenic differentiation /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BICH%202008%20WANGK.
Full textRider, Beverley J. "Immunoregulatory and cellular differentiation activity of apolipoprotein E-derived self peptides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq31117.pdf.
Full textMohamed, Ahmed Safwat Mohamed. "Molecular modelling and synthesis of novel ligands related to cellular differentiation." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54516/.
Full textChaffee, Blake Richard. "Cell Cycle Regulation and Cellular Differentiation in the Developing Ocular Lens." Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1437562575.
Full textWu, George Tatung. "The role of anaphase-promoting complex in cellular differentiation and tumorigenesis /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1528351821&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Full textDuong, Khanh Linh. "Molecular and cellular basis of hematopoietic stem cells maintenance and differentiation." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1448.
Full textMei, Hua. "The role of G[alpha]z during muscle differentiation /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20MEI.
Full textPitstick, Amy L. "Nuclear Reorganization and Gene Expression During Muscle Cell Differentiation." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1309997417.
Full textBuensuceso, Charito Saradpon. "Cellular and molecular characterisation of vanadate-induced phenotypic change in PC12 cells." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336446.
Full textNewsome, Philip N. "Studies on cellular engraftment and hepatocytic differentiation in liver injury and repair." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/27118.
Full textPreston, Thomas John. "Studies on the regulation of adipocytic differentiation by cellular and viral oncogenes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22382.pdf.
Full textGill, Robert James Montgomery. "Regulation and activity of cell cycle control factors in terminal cellular differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0024/NQ49922.pdf.
Full textAttias, Ortal. "The role of Rac1 in mouse podocyte cellular process formation and differentiation /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111588.
Full textPatel, Imran Iqbal. "Vibrational spectroscopy for the interrogation of mechanisms for cellular transformation and differentiation." Thesis, Lancaster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656331.
Full textHenderson, David John. "Studies on cellular differentiation in the dwarf tapeworm Hymenolepis nana (Cestoda: Cyclophyllidea)." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329352.
Full textNeems, Daniel. "The Formation and Function of Lineage Specific Nuclear Topologies during Cellular Differentiation." Thesis, Northwestern University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10044036.
Full textDNA is the physical medium for information storage inside of cells. Sub-regions of the DNA composed of linear stretches of nucleic acid sequences (DNA sequences), known as genes are the basic unit of storage in the human genome. Genes contain a myriad different types of information, of which a major class is protein coding genes. As the name suggests these genes hold the information required to make proteins, which then go on to perform cellular function and consequently dictate cellular activity and identity. Genes themselves are further grouped through the physical lineage of being contained on the same macromolecule known as chromosomes. The entire complement of chromosomes makes up the genome of the organism. In the case of humans, which are diploid, the genome is made up of 22 sets of autosomes and one set of sex chromosomes, a total of 46 discrete chromosomes. During interphase of the cell cycle all 46 of these chromosomes are found inside the nucleus in partially condensed, largely discrete regions known as chromosome territories.
The positioning of chromosome territories and the genes within them is non-random and has previously been demonstrated to be a function of gene expression. In order for a gene to be expressed, its sequence must be accessible to the RNA polymerases (RNAPs) that transcribe it, not tightly compacted around histones in an inaccessible form known as heterochromatin. As different types of cells need different types of proteins to function, and thus different genes to be expressed, the regions of the genome that are found in heterochromatin are cell type specific. The location of gene locus inside the nucleus relative to other sub-nuclear features such as RNAPII foci, known as transcription factories, also dictate expression. This relationship results in the interphase genome forming a cell type specific topology which is the result of the expressed genes. In spite of the persistent observation of cell type specific nuclear topologies, the factors that guide the formation and the function of observed topologies remains unclear.
Here, we test the relationship between linear and three-dimensional (3D) organization of gene regulation during myogenesis. Our analysis indicates that a subset of human chromosomes is significantly enriched for topologically associated domains (TADs) that contain muscle-specific genes. These lineage-enriched TADs demonstrate an expression dependent pattern of nuclear organization that also affects the positioning of non-enriched TADs. Therefore, lineage-enriched TADs affect cell-specific genome organization during myogenesis. The allelic spatial proximity of one of these domains, which encodes myogenin, reduces transcriptional variability. Moreover, this cell-specific nuclear topology is dependent on cell division. We propose that the linear and spatial organization of gene locus is functionally inter-dependent and that mitosis is critical in establishing this behavior during cellular differentiation.
We then extend this analysis into murine lymphocyte development. Specifically, we look at naturally occurring suppressive T-regulatory cells (Tregs ) that dampen the strength/severity of the immune response and have been demonstrated to be clinically relevant in the emergence and pathogenesis of auto-immune disorders. T-regulatory cells are an interesting model for studying lineage specific nuclear topologies because during an active immune response they are a mixed population of natural Tregs and induced Tregs that phenocopy each other but have different developmental histories. There is also clinical interest in finding a reliable means to make a distinction between these two cell types for the potential treatment of auto-immune disease. By studying features of nuclear organization for two candidate genes, FoxP3 and Helios, and the chromosomes they reside on, X and one respectively, we were able to distinguish these two populations of cells on the basis of nuclear topologies. We propose this distinction is the result of differing nuclear topologies in the progenitor population in conjunction with only a sub-set of regions, such as LE-TADs, showing lineage specific localizations. This would lead to remnants of progenitor topologies in terminal lineages. We also make the interesting observation of unexpectedly high rates of coalescence between the active and inactive X chromosomes in cells that specifically express the X-linked gene FoxP3. This finding may lead to transvection based silencing of FoxP3 and the increase in autoimmunity observed in females.
Collectively, this body of work furthers the understanding of how lineage specific nuclear topologies emerge as a function of gene expression and greatly expands the current understanding of how these topologies exert influence over the expression of genes.
Burr, Simon Jonathan. "The role of molecular oxygen in the epigenetic regulation of cellular differentiation." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-molecular-oxygen-in-the-epigenetic-regulation-of-cellular-differentiation(4eae590b-fa8b-4d9e-862d-69ad3452734e).html.
Full textPereira, Marie Antoinette Tanya. "Cellular differentiation and antibiotic production by Streptomyces nodosus immobilised in alginate capsules." View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/20504.
Full textA thesis submitted to the University of Western Sydney, College of Health and Science, School of Natural Sciences, as a requirement for the degree of Doctor of Philosophy. Includes bibliography.
Wilczynska, Katarzyna Marta. "Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation." VCU Scholars Compass, 2008. http://hdl.handle.net/10156/1772.
Full textChoi, Olivia J. "Spag17 Deficiency Impairs Neuronal Cell Differentiation in Developing Brain." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5877.
Full textJamie, Hajierah. "Possible crosstalk between signal transduction pathways in the induction of differentiation in HT-29 cells." Thesis, University of Port Elizabeth, 2000. http://hdl.handle.net/10948/d1019684.
Full textBarnett, David. "Activation antigens in the proliferation and differentiation of normal and malignant human leucocytes." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293382.
Full textLautenschlaeger, Franziska. "Cell compliance : cytoskeletal origin and importance for cellular function." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/239393.
Full textBiver, Galadrielle. "Identification and characterization of the control of murine MSC differentiation by the ADP receptors P2Y12 and P2Y13." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209334.
Full textTo determine the physiological roles of P2Y receptor family, our laboratory generated different strains of P2Y knockout mice (P2Y4 ,6 and 13). In collaboration with A. Gartland ,I. And Arnett TR Orriss ( Sheffield and London University) ,it has been observed that the P2Y13R-/- mice exhibit an impaired bone tissue metabolism that leads to a reduction in the volume of the femoral trabecular bone and the number of trabeculae. This phenotype is correlated with the decrease in the number of osteoblasts at the endo-cortical bone surface .
We therefore examined whether P2Y13 R activation was involved in the osteogenic differentiation of mesenchymal stem cells (MSCs). In the first part of our work we have shown that :
Induction of the MSCs differentiation is associated with the release of ATP and its conversion to ADP (agonist of the P2Y13R). ATP release probably involves the pannexine1 while the conversion of ATP into ADP is probably due to the activity of the ecto-nucleotidase CD39L1.
ADP stimulation of P2Y13 R+/+ (but not P2Y13 R-/-) adherent bone marrow stromal cells (BMSC) increased significantly the formation of alkaline phosphatase-colony forming units (CFU-ALP), as well as the expression of osteoblastic genes such as Osterix involved in the maturation of pre-osteoblasts into osteoblasts. The number of CFU-ALP obtained from P2Y13 R-/- BMSC and the level of osteoblastic gene expression after osteogenic stimulation were also strongly reduced compared to those obtained in wild-type cell cultures. In contrast, when P2Y13 R-/- BMSCs were incubated in an adipogenic medium, the number of adipocytes generated and the level of adipogenic gene expression (PPARγ2 and Adipsin) were higher than those obtained in P2Y13 R+/+ MSC. We also observed a significant increase of the number of bone marrow adipocytes in tibia of P2Y13 R-/- mice.
The P2ry12 gene deletion (also activated by ADP) also affects the ability of BMSCs to differentiate into osteoblasts but stimulates adipogenic differentiation.
In a second part of our work ,we have shown that the pro- osteogenic action of P2Y13R is indirect. Indeed ,this receptor is not expressed by MSCs but by adherent myeloid cells present in the bone marrow cell cultures (characterized by the expression of CD11b and CD45 markers) .In addition, we observed that following receptor activation by ADP ,these myeloid cells produce BMP2 factor.
We therefor propose that the stimulation of MSCs differentiation induces CD45- adherent cells to release ATP that is converted into ADP, most probably by the up-regulated CD39L1 ectonucleotidase. This ADP stimulates P2Y12R and P2Y13R expressed by CD45+/CD11b+ myeloid cells leading to the release of the osteogenic factor BMP2. This cytokine favours the maturation of pre-osteoblasts into osteoblasts and concomitantly inhibits the maturation of pre-adipocytes.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.
Full textMudumba, Sreenivasu. "Characterization of polyamine-induced differentiation in PC12 cells." Scholarly Commons, 1997. https://scholarlycommons.pacific.edu/uop_etds/2609.
Full textYang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.
Full textSun, Qian. "Cellular and molecular mechanisms of dendritic cell differentiation from cells of leukaemic origin." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38885335.
Full textCarthy, Jonathon Morgan. "Cellular and molecular biology of Wnt signaling and versican expression in myofibroblast differentiation." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39838.
Full textSun, Qian, and 孫倩. "Cellular and molecular mechanisms of dendritic cell differentiation from cells of leukaemic origin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38885335.
Full textMello, Cintra L. Muller Thias. "The role of cohesin in regulating early steps of cellular differentiation and reprogramming." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18023.
Full textFong, Lai-ping Iris, and 方麗萍. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971015.
Full textStrand, Laura Therese. "A Proteomic Analysis of Differentiation in the Mammary Epithelium." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/825.
Full textRoth, Ronelle. "Phenotypic characterization of maize bundle sheath defective mutants." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339349.
Full text