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Relevant bibliographies by topics / Cellular Delivery - Anionic Nanoparticles

Academic literature on the topic 'Cellular Delivery - Anionic Nanoparticles'

Author: Grafiati

Published: 7 September 2023

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Journal articles on the topic "Cellular Delivery - Anionic Nanoparticles"

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Maity, Amit Ranjan, and Nikhil R. Jana. "Chitosan−Cholesterol-Based Cellular Delivery of Anionic Nanoparticles." Journal of Physical Chemistry C 115, no. 1 (December 14, 2010): 137–44. http://dx.doi.org/10.1021/jp108828c.

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Xu, Zhi Ping, and G. Q. (Max) Lu. "Layered double hydroxide nanomaterials as potential cellular drug delivery agents." Pure and Applied Chemistry 78, no. 9 (January 1, 2006): 1771–79. http://dx.doi.org/10.1351/pac200678091771.

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This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.

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Choi, Soo-Jin, Jae-Min Oh, Taeun Park, and Jin-Ho Choy. "Cellular Toxicity of Inorganic Hydroxide Nanoparticles." Journal of Nanoscience and Nanotechnology 7, no. 11 (November 1, 2007): 4017–20. http://dx.doi.org/10.1166/jnn.2007.085.

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Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAl- and MgAl-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAl-LDH was determined to be slightly more toxic than MgAl-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers.

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Choi, Soo-Jin, Jae-Min Oh, Taeun Park, and Jin-Ho Choy. "Cellular Toxicity of Inorganic Hydroxide Nanoparticles." Journal of Nanoscience and Nanotechnology 7, no. 11 (November 1, 2007): 4017–20. http://dx.doi.org/10.1166/jnn.2007.18081.

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Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAl- and MgAl-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAl-LDH was determined to be slightly more toxic than MgAl-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers.

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Berger, Eric, Dalibor Breznan, Sandra Stals, Viraj J. Jasinghe, David Gonçalves, Denis Girard, Sylvie Faucher, Renaud Vincent, Alain R. Thierry, and Carole Lavigne. "Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages." Nanobiomedicine 4 (January 1, 2017): 184954351774625. http://dx.doi.org/10.1177/1849543517746259.

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Current antiretroviral drugs used to prevent or treat human immunodeficiency virus type 1 (HIV-1) infection are not able to eliminate the virus within tissues or cells where HIV establishes reservoirs. Hence, there is an urgent need to develop targeted delivery systems to enhance drug concentrations in these viral sanctuary sites. Macrophages are key players in HIV infection and contribute significantly to the cellular reservoirs of HIV because the virus can survive for prolonged periods in these cells. In the present work, we investigated the potential of the lipid-based Neutraplex nanosystem to deliver anti-HIV therapeutics in human macrophages using the human monocyte/macrophage cell line THP-1. Neutraplex nanoparticles as well as cationic and anionic Neutraplex nanolipoplexes (Neutraplex/small interfering RNA) were prepared and characterized by dynamic light scattering. Neutraplex nanoparticles showed low cytotoxicity in CellTiter-Blue reduction and lactate dehydrogenase release assays and were not found to have pro-inflammatory effects. In addition, confocal studies showed that the Neutraplex nanoparticles and nanolipoplexes are rapidly internalized into THP-1 macrophages and that they can escape the late endosome/lysosome compartment allowing the delivery of small interfering RNAs in the cytoplasm. Furthermore, HIV replication was inhibited in the in vitro TZM-bl infectivity assay when small interfering RNAs targeting CXCR4 co-receptor was delivered by Neutraplex nanoparticles compared to a random small interfering RNA sequence. This study demonstrates that the Neutraplex nanosystem has potential for further development as a delivery strategy to efficiently and safely enhance the transport of therapeutic molecules into human monocyte-derived macrophages in the aim of targeting HIV-1 in this cellular reservoir.

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Tsai, Li-Hui, Chia-Hsiang Yen, Hao-Ying Hsieh, and Tai-Horng Young. "Doxorubicin Loaded PLGA Nanoparticle with Cationic/Anionic Polyelectrolyte Decoration: Characterization, and Its Therapeutic Potency." Polymers 13, no. 5 (February 25, 2021): 693. http://dx.doi.org/10.3390/polym13050693.

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Optimized Doxorubicin hydrochloride (DOX) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (DPN) were prepared by controlling the water/oil distribution of DOX at different pH solutions and controlling the electrostatic interaction between DOX and different terminated-end PLGAs. Furthermore, cationic polyethylenimine (PEI) and anionic poly (acrylic acid) (PAA) were alternately deposited on DPN surface to form PEI-DPN (IDPN) and PAA-PEI-DPN (AIDPN) to enhance cancer therapy potency. Compared to DPN, IDPN exhibited a slower release rate in physiological conditions but PEI was demonstrated to increase the efficiency of cellular uptake and endo/lysosomal escape ability. AIDPN, with the outermost negatively charged PAA layer, still retained better endo/lysosomal escape ability compared to DPN. In addition, AIDPN exhibited the best pH-dependent release profile with 1.6 times higher drug release in pH 5.5 than in pH 7.4. Therefore, AIDPN with the characteristics of PEI and PAA simultaneously was the most optional cancer therapy choice within these three PLGA nanoparticles. As the proposed nanoparticles integrated optimal procedure factors, and possessed cationic and anionic outlayer, our drug delivery nanoparticles can provide an alternative solution to current drug delivery technologies.

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Rotan, Olga, Katharina N. Severin, Simon Pöpsel, Alexander Peetsch, Melisa Merdanovic, Michael Ehrmann, and Matthias Epple. "Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles." Beilstein Journal of Nanotechnology 8 (February 7, 2017): 381–93. http://dx.doi.org/10.3762/bjnano.8.40.

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The efficient intracellular delivery of (bio)molecules into living cells remains a challenge in biomedicine. Many biomolecules and synthetic drugs are not able to cross the cell membrane, which is a problem if an intracellular mode of action is desired, for example, with a nuclear receptor. Calcium phosphate nanoparticles can serve as carriers for small and large biomolecules as well as for synthetic compounds. The nanoparticles were prepared and colloidally stabilized with either polyethyleneimine (PEI; cationic nanoparticles) or carboxymethyl cellulose (CMC; anionic nanoparticles) and loaded with defined amounts of the fluorescently labelled proteins HTRA1, HTRA2, and BSA. The nanoparticles were purified by ultracentrifugation and characterized by dynamic light scattering and scanning electron microscopy. Various cell types (HeLa, MG-63, THP-1, and hMSC) were incubated with fluorescently labelled proteins alone or with protein-loaded cationic and anionic nanoparticles. The cellular uptake was followed by light and fluorescence microscopy, confocal laser scanning microscopy (CLSM), and flow cytometry. All proteins were readily transported into the cells by cationic calcium phosphate nanoparticles. Notably, only HTRA1 was able to penetrate the cell membrane of MG-63 cells in dissolved form. However, the application of endocytosis inhibitors revealed that the uptake pathway was different for dissolved HTRA1 and HTRA1-loaded nanoparticles.

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Uto, Tomofumi, Takami Akagi, Mitsuru Akashi, and Masanori Baba. "Induction of Potent Adaptive Immunity by the Novel Polyion Complex Nanoparticles." Clinical and Vaccine Immunology 22, no. 5 (March 25, 2015): 578–85. http://dx.doi.org/10.1128/cvi.00080-15.

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ABSTRACTThe development of effective and simple methods of vaccine preparation is desired for the prophylaxis and treatment of a variety of infectious diseases and cancers. We have created novel polyion complex (PIC) nanoparticles (NPs) composed of amphiphilic anionic biodegradable poly(γ-glutamic acid) (γ-PGA) and cationic polymers as a vaccine adjuvant. PIC NPs can be prepared by mixing γ-PGA-graft-l-phenylalanine ethylester (γ-PGA-Phe) polymer with cationic polymer in phosphate-buffered saline. We examined the efficacy of PIC NPs for antigen delivery and immunostimulatory activityin vitroandin vivo. PIC NPs enhanced the uptake of ovalbumin (OVA) by dendritic cells (DCs) and subsequently induced DC maturation. The immunization of mice with OVA-carrying PIC NPs induced potent and antigen-specific cellular and humoral immunity. Since PIC NPs can be created with water-soluble anionic γ-PGA-Phe and a cationic polymer by simple mixing in the absence of any organic solvents, PIC NPs may have potential as a novel candidate for an effective antigen carrier and vaccine adjuvant.

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Cotta, Karishma Berta, Sarika Mehra, and Rajdip Bandyopadhyaya. "pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages." Beilstein Journal of Nanotechnology 12 (October 7, 2021): 1127–39. http://dx.doi.org/10.3762/bjnano.12.84.

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Nanoparticle deployment in drug delivery is contingent upon controlled drug loading and a desired release profile, with simultaneous biocompatibility and cellular targeting. Iron oxide nanoparticles (IONPs), being biocompatible, are used as drug carriers. However, to prevent aggregation of bare IONPs, they are coated with stabilizing agents. We hypothesize that, zwitterionic drugs like norfloxacin (NOR, a fluoroquinolone) can manifest dual functionality – nanoparticle stabilization and antibiotic activity, eliminating the need of a separate stabilizing agent. Since these drugs have different charges, depending on the surrounding pH, drug loading enhancement could be pH dependent. Hence, upon synthesizing IONPs, they were coated with NOR, either at pH 5 (predominantly as cationic, NOR+) or at pH 10 (predominantly as anionic, NOR−). We observed that, drug loading at pH 5 exceeded that at pH 10 by 4.7–5.7 times. Furthermore, only the former (pH 5 system) exhibited a desirable slower drug release profile, compared to the free drug. NOR-coated IONPs also enable a 22 times higher drug accumulation in macrophages, compared to identical extracellular concentrations of the free drug. Thus, lowering the drug coating pH to 5 imparts multiple benefits – improved IONP stability, enhanced drug coating, higher drug uptake in macrophages at reduced toxicity and slower drug release.

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Tukova, Anastasiia, Inga Christine Kuschnerus, Alfonso Garcia-Bennett, Yuling Wang, and Alison Rodger. "Gold Nanostars with Reduced Fouling Facilitate Small Molecule Detection in the Presence of Protein." Nanomaterials 11, no. 10 (September 29, 2021): 2565. http://dx.doi.org/10.3390/nano11102565.

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Gold nanoparticles have the potential to be used in biomedical applications from diagnostics to drug delivery. However, interactions of gold nanoparticles with different biomolecules in the cellular environment result in the formation of a “protein corona”—a layer of protein formed around a nanoparticle, which induces changes in the properties of nanoparticles. In this work we developed methods to reproducibly synthesize spheroidal and star-shaped gold nanoparticles, and carried out a physico-chemical characterization of synthesized anionic gold nanospheroids and gold nanostars through transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential (ZP), nanoparticles tracking analysis (NTA), ultraviolet-visible (UV–Vis) spectroscopy and estimates of surface-enhanced Raman spectroscopy (SERS) signal enhancement ability. We analyzed how they interact with proteins after pre-incubation with bovine serum albumin (BSA) via UV–Vis, DLS, ZP, NTA, SERS, cryogenic TEM (cryo-TEM) and circular dichroism (CD) spectroscopy. The tests demonstrated that the protein adsorption on the particles’ surfaces was different for spheroidal and star shaped particles. In our experiments, star shaped particles limited the protein corona formation at SERS “hot spots”. This benefits the small-molecule sensing of nanostars in biological media. This work adds more understanding about protein corona formation on gold nanoparticles of different shapes in biological media, and therefore guides design of particles for studies in vitro and in vivo.

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Dissertations / Theses on the topic "Cellular Delivery - Anionic Nanoparticles"

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Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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Mendez, Eladio A. "Conjugated Polymer Nanoparticles for Biological Labeling and Delivery." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1837.

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Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. However, traditional treatments have proven insufficient for successful medical management of cancer due to the chemotherapeutics’ difficulty in achieving therapeutic concentrations at the target site, non-specific cytotoxicity to normal tissues, and limited systemic circulation lifetime. Although, a concerted effort has been placed in developing and successfully employing nanoparticle(NP)-based drug delivery vehicles successfully mitigate the physiochemical and pharmacological limitations of chemotherapeutics, work towards controlling the subcellular fate of the carrier, and ultimately its payload, has been limited. Because efficient therapeutic action requires drug delivery to specific organelles, the subcellular barrier remains critical obstacle to maximize the full potential of NP-based delivery vehicles. The aim of my dissertation work is to better understand how NP-delivery vehicles’ structural, chemical, and physical properties affect the internalization method and subcellular localization of the nanocarrier. In this work we explored how side-chain and backbone modifications affect the conjugated polymer nanoparticle (CPN) toxicity and subcellular localization. We discovered how subtle chemical modifications had profound consequences on the polymer’s accumulation inside the cell and cellular retention. We also examined how complexation of CPN with polysaccharides affects uptake efficiency and subcellular localization. This work also presents how changes to CPN backbone biodegradability can significantly affect the subcellular localization of the material. A series of triphenyl phosphonium-containing CPNs were synthesized and the effect of backbone modifications have on the cellular toxicity and intracellular fate of the material. A mitochondrial-specific polymer exhibiting time-dependent release is reported. Finally, we present a novel polymerization technique which allows for the controlled incorporation of electron-accepting benzothiadiazole units onto the polymer chain. This facilitates tuning CPN emission towards red emission. The work presented here, specifically, the effect that side-chain and structure, polysaccharide formulation and CPN degradability have on material’s uptake behavior, can help maximize the full potential of NP-based delivery vehicles for improved chemotherapeutic drug delivery.

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Khan, Md Arif. "NANOHARVESTING AND DELIVERY OF BIOACTIVE MATERIALS USING ENGINEERED SILICA NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/110.

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Mesoporous silica nanoparticles (MSNPs) possess large surface areas and ample pore space that can be readily modified with specific functional groups for targeted binding of bioactive materials to be transported through cellular barriers. Engineered silica nanoparticles (ESNP) have been used extensively to deliver bio-active materials to target intracellular sites, including as non-viral vectors for nucleic acid (DNA/RNA) delivery such as for siRNA induced interference. The reverse process guided by the same principles is called “nanoharvesting”, where valuable biomolecules are carried out and separated from living and functioning organisms using nano-carriers. This dissertation focuses on ESNP design principles for both applications. To investigate the bioactive materials loading, the adsorption of antioxidant flavonoids was investigated on titania (TiO2) functionalized MSNPs (mean particle diameter ~170 nm). The amount of flavonoid adsorbed onto particle surface was a strong function of active group (TiO2) grafting and a 100-fold increase in the adsorption capacity was observed relative to nonporous particles with similar TiO2 coverage. Active flavonoid was released from the particle surface using citric acid-mediated ligand displacement. Afterwards, nanoharvesting of flavonoids from plant hairy roots is demonstrated using ESNP in which TiO2 and amine functional groups are used as specific binding sites and positive surface charge source, respectively. Isolation of therapeutics was confirmed by increased pharmacological activity of the particles. After nanoharvesting, roots are found to be viable and capable of therapeutic re-synthesis. In order to identify the underlying nanoparticle uptake mechanism, TiO2 content of the plant roots was quantified with exposure to nanoparticles. Temperature (4 or 23 °C) dependent particle recovery, in which time dependent release of ESNP from plant cells showed a similar trend, indicated an energy independent process (passive transport). To achieve the selective separation and nanoharvesting of higher value therapeutics, amine functionalized MSNPs were conjugated with specific functional oligopeptides using a hetero-bifunctional linker. Fluorescence spectroscopy was used to confirm and determine binding efficiency using fluorescently attached peptides. Binding of targeted compounds was confirmed by solution depletion using liquid chromatography–mass spectrometry. The conjugation strategy is generalizable and applicable to harvest the pharmaceuticals produced in plants by selecting a specific oligopeptide that mimic the appropriate binding sites. For related gene delivery applications, the thermodynamic interaction of amine functionalized MSNPs with double-stranded (ds) RNA was investigated by isothermal titration calorimetry (ITC). The heat of interaction was significantly different for particles with larger pore size (3.2 and 7.6 nm) compared to that of small pore particles (1.6 nm) and nonporous particles. Interaction of dsRNA also depended on molecular length, as longer RNA (282 base pair) was unable to load into 1.6 nm particles, consistent with previous confocal microscopy observations. Calculated thermodynamic parameters (enthalpy, entropy and free energy of interaction) are essential to design pore size dependent dsRNA loading, protection and delivery using MSNP carriers. While seemingly diverse, the highly tunable nature of ESNP and their interactions with cells are broadly applicable, and enable facile nano-harvesting and delivery based on a continuous uptake-expulsion mechanism.

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Duong, Anthony David. "Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508.

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Li, Miao [Verfasser], and Jochen [Akademischer Betreuer] Feldmann. "Optical cellular delivery and intracellular sensing of fN forces using gold nanoparticles / Miao Li. Betreuer: Jochen Feldmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1110748965/34.

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Graf, Franziska. "DNA Origami Nanoparticles for Cell Delivery: The Effect of Shape and Surface Functionalization on Cell Internalization." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10259.

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An outstanding challenge in modern medicine is the safe and efficient delivery of drugs. One approach to improve drug delivery yield and increase specificity towards diseased cells, is to employ a drug carrier to facilitate transport. Promising steps towards developing such a carrier have been taken by the nascent field of nanomedicine: nanometer-sized particles designed to evade premature excretion, non-specific absorption, and the body’s immune response, can reduce undesired drug loss, while also increasing specific drug uptake into diseased cells through targeting surface modifications. However, progress is limited by incomplete knowledge of the ‘ideal’ nanoparticle design as well as a lack of appropriate high resolution construction methods for its implementation. DNA origami, a modular, nanometer-precise assembly method that would enable the rapid testing of particle properties as well as massively parallel fabrication, could provide an avenue to address these needs. In this thesis, I employed the DNA origami method to investigate how nanoscale shape and ligand functionalization affect nanoparticle uptake into cultured endothelial cells. In the first part, I evaluated the uptake yield of a series of eight shapes that ranged from 7.5 nm to 400 nm in their individual dimensions. The best performing shape of that study, a 15 × 100 nm DNA origami nanocylinder, was internalized 18-fold better than a dsDNA control of the same molecular weight. In a follow up study, I decorated this nanocylinder with integrin-targeting cyclic RGD peptides. This surface functionalization increased cellular uptake another 13-fold. In addition, uptake yield and the ratio of internalized versus surface-bound particles depended on the number of ligands present on the nanoparticle surface. This work represents a significant first step towards attaining the ability to design and implement an 'ideal' nanoparticle drug carrier. In the future, the DNA origami method can be used as a platform technology to further expand our understanding of transport properties of drug carriers and achieve safer and more efficient drug delivery.

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Nitin, Nitin. "Optical and MR Molecular Imaging Probes and Peptide-based Cellular Delivery for RNA Detection in Living Cells." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08102005-120350/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.
Dr. X. Hu, Committee Member ; Dr. Al Merrill, Committee Member ; Dr. Niren Murthy, Committee Member ; Dr. Gang Bao, Committee Chair ; Dr. Nicholas Hud, Committee Member. Includes bibliographical references.

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Huang, Xiaomeng. "Targeted Delivery of MicroRNAs by Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405095496.

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Liebsch, Nicole Verfasser], and Claus-Michael [Akademischer Betreuer] [Lehr. "Cationic polymer coating of PLGA nanoparticles for enabling cellular delivery of siRNA / Nicole Liebsch ; Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-ds-271196.

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Liebsch, Nicole [Verfasser], and Claus-Michael [Akademischer Betreuer] Lehr. "Cationic polymer coating of PLGA nanoparticles for enabling cellular delivery of siRNA / Nicole Liebsch ; Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1155760522/34.

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Books on the topic "Cellular Delivery - Anionic Nanoparticles"

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Akashi, Misturu, Takami Akagi, and Michiya Matsusaki. Engineered Cell Manipulation for Biomedical Application. Springer Japan, 2014.

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Akashi, Misturu, Takami Akagi, and Michiya Matsusaki. Engineered Cell Manipulation for Biomedical Application. Springer, 2016.

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Akashi, Misturu, Takami Akagi, and Michiya Matsusaki. Engineered Cell Manipulation for Biomedical Application. Springer, 2014.

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Book chapters on the topic "Cellular Delivery - Anionic Nanoparticles"

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Barin, Gozde, Yakup Gultekin, Pezik, Naile Ozturk, Asli Kara, and Imran Vural. "Cellular Uptake and Transcytosis." In Drug Delivery with Targeted Nanoparticles, 247–79. New York: Jenny Stanford Publishing, 2021. http://dx.doi.org/10.1201/9781003164739-10.

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Kumari, Avnesh, Rubbel Singla, Anika Guliani, Amitabha Acharya, and Sudesh Kumar Yadav. "Cellular Response of Therapeutic Nanoparticles." In Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration, 153–72. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0818-4_7.

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Nagelli, Christopher V., Christopher H. Evans, and Rodolfo E. De la Vega. "Gene Delivery to Chondrocytes." In Advances in Experimental Medicine and Biology, 95–105. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25588-5_7.

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AbstractDelivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different viral and non-viral vectors for this purpose. These vectors may be deployed in an ex vivo fashion, where chondrocytes are genetically modified outside the body, or by in vivo delivery where the vector is introduced directly into the body; in the case of articular and meniscal cartilage in vivo delivery is typically by intra-articular injection. Ex vivo delivery is favored in strategies for enhancing cartilage repair as these can be piggy-backed on existing cell-based technologies, such as autologous chondrocyte implantation, or used in conjunction with marrow-stimulating techniques such as microfracture. In vivo delivery to articular chondrocytes has proved more difficult, because the dense, anionic, extra-cellular matrix of cartilage limits access to the chondrocytes embedded within it. As Grodzinsky and colleagues have shown, the matrix imposes strict limits on the size and charge of particles able to diffuse through the entire depth of articular cartilage. Empirical observations suggest that the larger viral vectors, such as adenovirus (~100 nm), are unable to transduce chondrocytes in situ following intra-articular injection. However, adeno-associated virus (AAV; ~25 nm) is able to do so in horse joints. AAV is presently in clinical trials for arthritis gene therapy, and it will be interesting to see whether human chondrocytes are also transduced throughout the depth of cartilage by AAV following a single intra-articular injection. Viral vectors have been used to deliver genes to the intervertebral disk but there has been little research on gene transfer to chondrocytes in other cartilaginous tissues such as nasal, auricular or tracheal cartilage.

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Smirnov, Pierre. "Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anticancer Therapy." In Methods in Molecular Biology™, 333–53. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-530-9_19.

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"In Vitro Characterization of Nanoparticle Cellular Interaction." In Drug Delivery Nanoparticles Formulation and Characterization, 189–209. CRC Press, 2016. http://dx.doi.org/10.3109/9781420078053-15.

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"Animal and Cellular Models for Use in Nanoparticles Safety Study." In Nanomedicine in Drug Delivery, 371–447. CRC Press, 2013. http://dx.doi.org/10.1201/b14802-16.

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Macedo, Letícia Bueno, Cristiane Franco Codevilla, Daniela Mathes, Bianca Costa Maia, Clarice Madalena Bueno Rolim, and Daniele Rubert Nogueira-Librelotto. "Biofate and cellular interactions of PLGA nanoparticles." In Poly(Lactic-Co-glycolic Acid) (PLGA) Nanoparticles for Drug Delivery, 87–119. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-91215-0.00003-0.

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Liu, Fuguo, Xiuping Liang, Xueqi Li, and Zhaowei Jiang. "Self-assembled Nanoparticle-based Systems." In Bioactive Delivery Systems for Lipophilic Nutraceuticals, 444–76. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839165566-00444.

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Self-assembled nanoparticles are promising carriers for food delivery applications due to their large specific surface area, good dispersibility, biocompatibility, bioavailability, high cell absorption rates and environmental friendliness. This chapter summarizes the latest information on self-assembled nanoparticles, including composition and structures, physicochemical properties, and preparation and modification methods. Besides, this chapter also discusses the advantages and disadvantages of self-assembled nanoparticles and their applications in the delivery of active substances. Self-assembled nanoparticle systems can be endowed with different functional properties by controlling their physicochemical properties, and then used to deliver different lipophilic nutrients. The functional properties of nanoparticles can be optimized by various preparation methods and non-covalent and covalent modifications. Future research may focus on the design of nanoparticles loaded with functional ingredients in a multidisciplinary manner to achieve co-encapsulation, co-protection and precise targeted delivery. Through technical analysis at the cellular and molecular levels, the delivery mechanism and the site of action of nanoparticles in the human body will be evaluated in depth.

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"Quantum Dots Based Material for Drug Delivery Applications." In Materials Research Foundations, 191–215. Materials Research Forum LLC, 2021. http://dx.doi.org/10.21741/9781644901250-8.

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Quantum dots (QDs) have shown promising potential to many biomedical and biological applications, mainly in drug delivery or activation and cellular imaging. These semiconductor nanoparticles, QDs, whose particle size is in the range of 2-10 nanometer with unique photo-chemical and -physical properties that are not possessed by any other isolated molecules, have become one of the distinct class of imaging probes and worldwide platforms for manufacturing of multifunctional nanodevices. In this chapter, properties, applications of QDs, and importance in the biomedical field especially in drug delivery is presented.

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Gore, Kapil, Sankha Bhattacharya, and Bhupendra G. Prajapati. "Recent Pharmaceutical Developments in the Treatment of Cancer Using Nanosponges." In Advances in Drug Delivery Methods [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105817.

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Nanosponges are a class of nanoparticles characterized by their sponge-like surface that ensures high loading capacity. Cancer causes high mortality and requires precise treatment without harming the body. Hence, nanoparticles are required to target medications to tumor. Nanosponges may be synthesized from various polymers and metals, giving them distinct properties. The majority of polymer synthesis entails crosslinking, while metal synthesis entails the isolation of metal nanoparticles accompanied by their assembly into sponges. Nanosponges must be functionalized to precisely attack tumors. There are several patents on nanosponges synthesis and their use. Future trends in the usage of nanosponges include simultaneous distribution of several molecules and expanding the spectrum of use from medicinal delivery to substance encapsulation for a multitude of applications. As their usage in the pharmaceutical industry grows, more emphasis should be put on toxicity-related aspects induced by the near association of cell membrane and nanosponge resulting in intracellular dissolution or reactive oxygen species (ROS) generation, which in turn damages various cellular components. Many techniques have been created to reduce toxicity, including functionalization with various materials such as antioxidants, polymers and altering nanosponges composition. As the application of nanosponges increases in many industries, the phenomenon related to toxicity must be further explored through research.

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Conference papers on the topic "Cellular Delivery - Anionic Nanoparticles"

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Sangtani, Ajmeeta, Russ Algar, Guillermo Lasarte-Aragonés, Kimihiro Susumu, Alan L. Huston, Igor L. Medintz, James B. Delehanty, Eleonara Petryayeva, Miao Wu, and Eunkeu Oh. "Nanoparticle bioconjugate for controlled cellular delivery of doxorubicin." In Colloidal Nanoparticles for Biomedical Applications XIII, edited by Xing-Jie Liang, Wolfgang J. Parak, and Marek Osiński. SPIE, 2018. http://dx.doi.org/10.1117/12.2290031.

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Nieto-Chaupis, Huber. "Modeling the Electrodynamics of Cellular Uptake of Nanoparticles at Drug Delivery Strategies." In 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE). IEEE, 2022. http://dx.doi.org/10.1109/bibe55377.2022.00077.

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Yum, Kyungsuk, Sungsoo Na, Yang Xiang, Ning Wang, and Min-Feng Yu. "Nanomechanochemical Delivery of Nanoparticles for Nanomechanics Inside Living Cells." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13039.

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Studying biological processes and mechanics in living cells is challenging but highly rewarding. Recent advances in experimental techniques have provided numerous ways to investigate cellular processes and mechanics of living cells. However, most of existing techniques for biomechanics are limited to experiments outside or on the membrane of cells, due to the difficulties in physically accessing the interior of living cells. On the other hand, nanomaterials, such as fluorescent quantum dots (QDs) and magnetic nanoparticles, have shown great promise to overcome such limitations due to their small sizes and excellent functionalities, including bright and stable fluorescence and remote manipulability. However, except a few systems, the use of nanoparticles has been limited to the study of biological studies on cell membranes or related to endocytosis, because of the difficulty of delivering dispersed and single nanoparticles into living cells. Various strategies have been explored, but delivered nanoparticles are often trapped in the endocytic pathway or form aggregates in the cytoplasm, limiting their further use. Here we show a nanoscale direct delivery method, named nanomechanochemical delivery, where we manipulate a nanotube-based nanoneedle, carrying “cargo” (QDs in this study), to mechanically penetrate the cell membrane, access specific areas inside cells, and release the cargo [1]. We selectively delivered well-dispersed QDs into either the cytoplasm or the nucleus of living cells. We quantified the dynamics of the delivered QDs by single-molecule tracking and demonstrated the applicability of the QDs as a nanoscale probe for studying nanomechanics inside living cells (by using the biomicrorhology method), revealing the biomechanical heterogeneity of the cellular environment. This method may allow new strategies for studying biological processes and mechanics in living cells with spatial and temporal precision, potentially at the single-molecule level.

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Liu, Xuan, Zhaoxiong Wan, Yuanwei Zhang, and Yuwei Liu. "Optically computed phase microscopy to assess cellular uptake of lipid nanoparticles." In CLEO: Applications and Technology. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.atu5i.6.

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We developed a novel optically computed phase microscopy (OCPM) system, for depth-resolved phase imaging. We used OCPM to assess cellular uptake of lipid nanoparticles (LNPs), for the optimization of drug delivery systems based on LNPs.

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Mulvana, Helen, Julien Reboud, Maria de Scrilli, and Catherine Berry. "Uptake and cellular recovery mechanisms in microbubble-enhanced ultrasound delivery of nanoparticles for cancer therapy." In 2015 IEEE International Ultrasonics Symposium (IUS). IEEE, 2015. http://dx.doi.org/10.1109/ultsym.2015.0403.

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Ibarra, Luis Exequiel, Lucia Beaugé, Carlos Chesta, Viviana Alicia Rivarola, and Rodrigo Palacios. "Exploiting cellular delivery of conjugated polymer nanoparticles for improved photodynamic therapy in a 3D glioblastoma model." In 17th International Photodynamic Association World Congress, edited by Tayyaba Hasan. SPIE, 2019. http://dx.doi.org/10.1117/12.2526763.

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Zhang, Wujie, Jianhua Rong, Qian Wang, and Xiaoming He. "Synthesis, Cellular Uptake, and Cytotoxicity of a Thermally Responsive Nanocapsule." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206872.

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Recently, polymeric nanoparticles have attracted tremendous interests as a useful tool to encapsulate therapeutic drugs, genes, and proteins for their controlled and sustained delivery. Among them, polymeric hydrogel nanoparticles with thermal and/or pH responsiveness have attracted particular attention [1]. Trehalose, a non-reducing disaccharide of glucose, has been demonstrated to be a potent, nontoxic bioprotectant for stabilizing lipids, proteins, viruses, and blood cells at cryogenic and particularly, ambient temperatures (i.e., cryo and lyopreservation) [2]. However, intracellular delivery of trehalose into small eukaryotic mammalian cells in a large quantity for biostabilization purpose has not been very successful so far [2]. In this study, a thermally responsive polymeric nanocapsule was synthesized and characterized with the aim to encapsulate trehalose for its intracellular delivery.

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Afadzi, Mercy, Siv Eggen, Yrr Morch, Per Stenstad, Rune Hansen, Bjorn Angelsen, and Catharina de Lange Davies. "Multifunctional nanoparticles for drug delivery and imaging: Effect of ultrasound on cellular uptake and tumor tissue distribution." In 2012 IEEE International Ultrasonics Symposium. IEEE, 2012. http://dx.doi.org/10.1109/ultsym.2012.0104.

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Rahman, Mohammad Aminur, Pengfei Wang, Dongsheng Wang, Selwyn J. Hurwitz, Zhengjia Chen, Zhuo G. Chen, Yonggang Ke, and Dong M. Shin. "Abstract 187: Efficient delivery of Bcl2 siRNA by DNA nanoparticles to inhibit cellular growth and cancer progression." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-187.

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Lian, Xizhen, Alfredo Erazo-Oliveras, Hong-Cai Zhou, and Jean-Philippe Pellois. "Delivery of nanoparticles inside the cytosol of live cells for the monitoring of cellular processes (Conference Presentation)." In Advances in Photonics of Quantum Computing, Memory, and Communication XI, edited by Zameer U. Hasan, Philip R. Hemmer, Alan L. Migdall, and Alan E. Craig. SPIE, 2018. http://dx.doi.org/10.1117/12.2300544.

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