Relevant bibliographies by topics / Cell stretching device

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Cell stretching device'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Cell stretching device"

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Yadav, Sharda, Pradip Singha, Nhat-Khuong Nguyen, Chin Hong Ooi, Navid Kashaninejad, and Nam-Trung Nguyen. "Uniaxial Cyclic Cell Stretching Device for Accelerating Cellular Studies." Micromachines 14, no. 8 (July 31, 2023): 1537. http://dx.doi.org/10.3390/mi14081537.

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Cellular response to mechanical stimuli is a crucial factor for maintaining cell homeostasis. The interaction between the extracellular matrix and mechanical stress plays a significant role in organizing the cytoskeleton and aligning cells. Tools that apply mechanical forces to cells and tissues, as well as those capable of measuring the mechanical properties of biological cells, have greatly contributed to our understanding of fundamental mechanobiology. These tools have been extensively employed to unveil the substantial influence of mechanical cues on the development and progression of various diseases. In this report, we present an economical and high-performance uniaxial cell stretching device. This paper reports the detailed operation concept of the device, experimental design, and characterization. The device was tested with MDA-MB-231 breast cancer cells. The experimental results agree well with previously documented morphological changes resulting from stretching forces on cancer cells. Remarkably, our new device demonstrates comparable cellular changes within 30 min compared with the previous 2 h stretching duration. This third-generation device significantly improved the stretching capabilities compared with its previous counterparts, resulting in a remarkable reduction in stretching time and a substantial increase in overall efficiency. Moreover, the device design incorporates an open-source software interface, facilitating convenient parameter adjustments such as strain, stretching speed, frequency, and duration. Its versatility enables seamless integration with various optical microscopes, thereby yielding novel insights into the realm of mechanobiology.
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Huang, Lawrence, Pattie S. Mathieu, and Brian P. Helmke. "A Stretching Device for High-Resolution Live-Cell Imaging." Annals of Biomedical Engineering 38, no. 5 (March 2, 2010): 1728–40. http://dx.doi.org/10.1007/s10439-010-9968-7.

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Shao, Yue, Xinyu Tan, Roman Novitski, Mishaal Muqaddam, Paul List, Laura Williamson, Jianping Fu, and Allen P. Liu. "Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions." Review of Scientific Instruments 84, no. 11 (November 2013): 114304. http://dx.doi.org/10.1063/1.4832977.

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HAYASHI, Tatsuya, Tasuku NAKAHARA, Katsuya SATO, and Kazuyuki MINAMI. "Development of cell stretching micro device having micro chamber array." Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP 2016 (2016): E—2–5. http://dx.doi.org/10.1299/jsmeiip.2016.e-2-5.

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Kreutzer, Joose, Marlitt Viehrig, Risto-Pekka Pölönen, Feihu Zhao, Marisa Ojala, Katriina Aalto-Setälä, and Pasi Kallio. "Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes." Biomechanics and Modeling in Mechanobiology 19, no. 1 (August 23, 2019): 291–303. http://dx.doi.org/10.1007/s10237-019-01211-8.

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Sato, Kae, Manami Nitta, and Aiko Ogawa. "A Microfluidic Cell Stretch Device to Investigate the Effects of Stretching Stress on Artery Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension." Inventions 4, no. 1 (December 26, 2018): 1. http://dx.doi.org/10.3390/inventions4010001.

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A microfluidic cell stretch device was developed to investigate the effects of stretching stress on pulmonary artery smooth muscle cell (PASMC) proliferation in pulmonary arterial hypertension (PAH). The microfluidic device harbors upper cell culture and lower control channels, separated by a stretchable poly(dimethylsiloxane) membrane that acts as a cell culture substrate. The lower channel inlet was connected to a vacuum pump via a digital switch-controlled solenoid valve. For cyclic stretch at heartbeat frequency (80 bpm), the open or close time for each valve was set to 0.38 s. Proliferation of normal PASMCs and those obtained from patients was enhanced by the circumferential stretching stimulation. This is the first report showing patient cells increased in number by stretching stress. These results are consistent with the abnormal proliferation observed in PAH. Circumferential stretch stress was applied to the cells without increasing the pressure inside the microchannel. Our data may suggest that the stretch stress itself promotes cell proliferation in PAH.
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Kamble, Harshad, Raja Vadivelu, Mathew Barton, Kseniia Boriachek, Ahmed Munaz, Sungsu Park, Muhammad Shiddiky, and Nam-Trung Nguyen. "An Electromagnetically Actuated Double-Sided Cell-Stretching Device for Mechanobiology Research." Micromachines 8, no. 8 (August 22, 2017): 256. http://dx.doi.org/10.3390/mi8080256.

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SHIMONO, Akihiro, Katsuya SATO, and Kazuyuki MINAMI. "321 Fabrication of micro link mechanism for single cell stretching device." Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME 2007.20 (2008): 119–20. http://dx.doi.org/10.1299/jsmebio.2007.20.119.

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MONJI, Ryo, Kazuyuki MINAMI, Yuta NAKASHIMA, Katsuya SATO, and Keigo NAKANO. "716 Design and Fabrication of Highly Precise Cell Stretching Micro Device." Proceedings of Conference of Chugoku-Shikoku Branch 2011.49 (2011): 195–96. http://dx.doi.org/10.1299/jsmecs.2011.49.195.

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HAJI, Shigeyuki, Katsuya SATO, and Kazuyuki MINAMI. "A211 Development of electro-static actuator for micro cell stretching device." Proceedings of the JSME Conference on Frontiers in Bioengineering 2007.18 (2007): 97–98. http://dx.doi.org/10.1299/jsmebiofro.2007.18.97.

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Dissertations / Theses on the topic "Cell stretching device"

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Chagnon-Lessard, Sophie. "Cellular Responses to Complex Strain Fields Studied in Microfluidic Devices." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37915.

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Cells in living organisms are constantly experiencing a variety of mechanical cues. From the stiffness of the extra cellular matrix to its topography, not to mention the presence of shear stress and tension, the physical characteristics of the microenvironment shape the cells’ fate. A rapidly growing body of work shows that cellular responses to these stimuli constitute regulatory mechanisms in many fundamental biological functions. Substrate strains were previously shown to be sensed by cells and activate diverse biochemical signaling pathways, leading to major remodeling and reorganization of cellular structures. The majority of studies had focused on the stretching avoidance response in near-uniform strain fields. Prior to this work, the cellular responses to complex planar strain fields were largely unknown. In this thesis, we uncover various aspects of strain sensing and response by first developing a tailored lab-on-a-chip platform that mimics the non-uniformity and complexity of physiological strains. These microfluidic cell stretchers allow independent biaxial control, generate cyclic stretching profiles with biologically relevant strain and strain gradient amplitudes, and enable high resolution imaging of on-chip cell cultures. Using these microdevices, we reveal that strain gradients are potent mechanical cues by uncovering the phenomenon of cell gradient avoidance. This work establishes that the cellular mechanosensing machinery can sense and localize changes in strain amplitude, which orchestrate a coordinated cellular response. Subsequently, we investigate the effect of multiple changes in stretching directions to further explore mechanosensing subtleties. The evolution of the cellular response shed light on the interplay of the strain avoidance and the newly demonstrated strain gradient avoidance, which were found to occur on two different time scales. Finally, we extend our work to study the influence of cyclic strains on the early stages of cancer development in epithelial tissues (using MDCK-RasV12 system), which was previously largely unexplored. This work reveals that external mechanical forces impede the healthy cells’ ability to eliminate newly transformed cells and greatly promote invasive protrusions, as a result of their different mechanoresponsiveness. Overall, not only does our work reveal new insights regarding the long-range organization in population of cells, but it may also contribute to paving the way towards new approaches in cancer prevention treatments.
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Chatterjee, Aritra. "Role of Fiber Orientations in the Mechanobiology of Cells under Stretch." Thesis, 2021. https://etd.iisc.ac.in/handle/2005/5632.

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Fiber reinforcement plays an important role in the structure and function of biological materials. Soft connective tissues in human body like artery, heart tissues, skin etc. exhibit anisotropic material responses due to the orientation of fibers along specific directions. At a cellular level, stress fibers in the cytoskeleton play an important role in maintaining cellular shape and influence cell adhesion, migration, and contractility. Cells respond to changes in their mechanical milieu and drive biochemical processes which induce growth and remodeling of the underlying material properties. This results in non-uniform changes to the structural form and function over time. Continuum mechanics-based approaches to address biological growth and remodeling demonstrate an intimate relationship between the cellular level mechanobiology and the underlying tissue properties. How does orientation of fibers affect mechanical response of tissues? How do mechanosensing processes influence cellular growth and remodeling under stretch? I have combined experimental techniques and analytical models, to quantify structure-property correlations in cells and biomimetic materials under stretch. In the first study, we investigated the role of fiber orientations in the mechanics of bioinspired fiber reinforced elastomers (FRE) fabricated to mimic tissue architectures. We fabricated FRE materials in transversely isotropic layouts and characterized the nonlinear stress-strain relationships using uniaxial and equibiaxial experiments. We used these data within a continuum mechanical framework to propose a novel constitutive model for incompressible FRE materials with embedded extensible fibers. The model shows that the interaction between the fiber and matrix along with individual contributions from the matrix and fibers were crucial in capturing the stress-strain responses in the FRE composites. The deviatoric stress components show inversion at fiber orientation angles near the magic angle (54.7°) in the FRE composites. These results are useful in soft robotic applications and in the biomechanics of fiber reinforced tissues. Secondly, we apply these formulations at a cellular level to quantify the role of stress fiber elongation and realignment to changes in cellular morphomechanics under uniaxial cyclic stretch. Cyclic uniaxial stretching results in cellular reorientation orthogonal to the applied stretch direction via a strain avoidance reaction. We show that uniaxial cyclic stretch induces stress fiber lengthening, realignment and increase in cortical actin in fibroblasts stretched over varied amplitudes and durations. Higher amounts of actin and realignment of stress fibers were accompanied with an increase in the effective elastic modulus of cells. We modelled stress fiber growth and reorientation dynamics using a nonlinear, orthotropic, fiber-reinforced continuum representation of the cell. The model predictions match the observed increased cellular stiffness under uniaxial cyclic stretch. As a final study, we have designed and fabricated a microscope mountable cell-stretching device and used it to quantify stretch-induced changes in cellular contractility by measuring the changes cellular traction forces. Our results show a significant 2 increase in cellular traction forces when subjected to prolonged duration of cyclic stretch. Together, these studies demonstrate the importance of uniaxial stretching in mechanotransduction processes which are essential in understanding growth processes and in disease models of fibrosis.
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Book chapters on the topic "Cell stretching device"

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Kumar, Sudheer, and Sukhila Krishnan. "Nanomaterials for Flexible Photovoltaic Fabrics." In Current and Future Developments in Nanomaterials and Carbon Nanotubes, 258–71. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050714122030018.

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The development of extremely flexible photovoltaic (PV) devices for energy harvesting and storage applications is currently receiving more attention by the researchers from industries. The presently available energy storage devices are too rigid and extensive and also not suitable for next-generation flexible electronics such as silicon-based solar cells. Thus, the researchers have developed high-performance, lightweight, conformable, bendable, thin, and flexible dependable devices. On the other hand, these energy storage devices require to be functional under different mechanical deformations, for example, bending, twisting, and even stretching. The nanomaterial (TiO2 , ZnO, Ag, etc.) coated fabrics also play a vital role in improving the efficiency of the solar cell (devices) to a great extent. The current chapter provides information about the development of nanomaterials-based flexible photovoltaic solar cell devices for wearable textile industry applications. The fabricated carbon ink printed fabrics such as polyester, cotton woven and nonwoven, and polyethylene terephthalate nonwoven can be used as cathode and heating sources of PV devices. The organic and flexible conductive substrate printed with carbon ink can be utilized as heating source fabrics for wearable electronics devices. The flexible substrate-based photovoltaics (PV) device is mostly used in the textile industries due to its flexibility, environmental friendliness, low cost as well as easy processability. The flexible-wearable photovoltaic devices pave the way to be used for enormous applications in various fields.
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Conference papers on the topic "Cell stretching device"

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Clark, William W., Randall Smith, Katherine Janes, John Winkler, and Michael Mulcahy. "Development of a piezoelectrically actuated cell stretching device." In SPIE's 7th Annual International Symposium on Smart Structures and Materials, edited by Jack H. Jacobs. SPIE, 2000. http://dx.doi.org/10.1117/12.388171.

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Shan, Yingfeng, Jacob Dodson, Sheena Abraham, John E. Speich, Raj Rao, and Kam K. Leang. "A Biaxial Shape Memory Alloy Actuated Cell/Tissue Stretching System." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-42266.

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In this article, we describe the design of a shape memory alloy-based system to stretch cells cultured on top of a flexible membrane in multi-directions (longitudinal and transverse). Mechanical cues (such as strain and force) can affect the state and behavior of cells, such as, morphology, the differentiation process, and apoptosis. Therefore, a thorough understanding of the effects of mechanical perturbations on cells/tissues will have a deep impact in the biological sciences. The proposed design allows application of anisotropic (multi-axial) strain with high-precision. Certain cells, for example endothelial cells that line the inside of blood vessels, experience multi-axial (circumferential and longitudinal) stresses and strains. A cell stretching device that enables controlled application of biaxial strain will allow for systematic and accurate studies of the effects of externally applied mechanical perturbation throughout the cell, tissue, or organ. A preliminary design is proposed that exploits the strain recovery property of the shape memory alloy (SMA) actuators. We describe the design of the mechanical system and show experimental results to demonstrate stretching of a thin PDMS membrane in the longitudinal and transverse directions. To account for the inherent nonlinearity of the SMA, a feedback controller is implemented to achieve high-precision control of the stretching process. Additionally, the design can be integrated with an atomic force microscope (AFM) for high spatial and temporal resolution studies.
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Mann, Jennifer, Raymond Lam, and Jianping Fu. "Cellular Response to Stretch by Modulation of Cytoskeletal Tension in Two Distinct Phases." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-54016.

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External forces are increasingly recognized as major regulators of cell structure and function, yet the underlying mechanism by which cells sense force and transduce it into intracellular biochemical signals and behavioral responses (‘mechanotransduction’) is largely undetermined. To aid in the mechanistic study of mechanotransduction, we devised a novel cell stretching device that allows for quantitative control and real-time measurement of mechanical stimuli and cellular biomechanical responses. Using this device, we studied the subcellular dynamic responses of contractile force and adhesion remodeling of vascular smooth muscle cells (VSMCs) to stretch. Our data showed that VSMCs could acutely enhance their contraction to resist rapid cell deformation, but they could also allow slow adaptive inelastic cytoskeletal reorganization in response to sustained cell stretch. Our study may help elucidate the mechanotransduction system in smooth muscle cells, and thus contribute to our understanding of pressure-induced vascular disease processes.
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Kollimada, Somanna A., Sambuddha Khan, Sreenath Balakrishna, Shilpa Raju, Suma Matad, and G. K. Ananthasuresh. "A micro-mechanical compliant device for individual cell-stretching, compression, and in-situ force-measurement." In 2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS). IEEE, 2017. http://dx.doi.org/10.1109/marss.2017.8001943.

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Sasoglu, F. Mert, Devrim Kilinc, Kathleen Allen, and Bradley Layton. "Parallel Force Measurement in Cell Arrays." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-42472.

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The primary goal of this work is to establish a robust, repeatable method for growing forebrain nerve cells in a parallel manner by stretching them using a microfabricated PDMS beam array and printing arrays of neurons. The highly compliant, transparent, biocompatible PDMS micro beam array may offer a method for more rapid throughput in cell and protein mechanics force measurement experiments with sensitivities necessary for highly compliant structures such as axons. This work has two endpoints. One is to use a neural array as an experimental testbed for investigating neuronal cell growth hypotheses. The other endpoint is to build a neuronal-based, biosensor device capable of acting as a cell-based sensor. We present preliminary results for microbeams attaching to nerve cells. The attachment ratio the life-length and the axon lengths of the chick forebrain cells on microprinted spots will also be compared with an equivalent protein coated area of cells.
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Zhang, Xudong, Remi Petrissans, Fang Li, and Ioana Voiculescu. "Stretchable Impedance Spectroscopy Sensor for Mammalian Cells Impedance Measurements." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-37737.

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In this paper, an impedance spectroscopy biosensor fabricated on a stretchable substrate has been investigated. A thin stretchable membrane integrated with an impedance biosensor tolerated cyclic strain without cracking. The electric cell-substrate impedance spectroscopy (ECIS) technique has been used to monitor the impedance of the membrane of bovine aortic endothelial cells (BAEC). Integrating mechanical stretching and ECIS sensing onto a single platform requires biocompatible, highly flexible, and reversibly stretchable (elastic) materials for device fabrication. In addition, the interfacial impedance of electrode material to electrolyte should be small to improve the sensitivity of the impedance measurements. In this research, the biocompatible and stretchable membrane was fabricated from polydimethylsiloxane (PDMS), and the ECIS sensor was fabricated on pre-stretched PDMS membrane using sputtering microfabrication and pattern-transferring processes. The stretchable membrane, integrated with the ECIS sensor, can be used to simulate the dynamic environment of organisms and enable the analysis of the cell activity in vitro.
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Islam, Tanveer ul, and Prasanna S. Gandhi. "Controlling Interfacial Flow Instability via Micro Engineered Surfaces Towards Multiscale Channel Fabrication." In ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icnmm2018-7668.

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Hierarchical branched structures exist in nature in diverse forms, functions and scales stretching from micro to very large sizes. Typically effective as heat and mass transfer networks, ordered hierarchal/ multiscale branched/ tree-like networks could be fabricated by controlling a fluid reshaping process in a device called ‘Multiport Hele-Shaw cell’. Control over the instability by employing micro-modified cell plates, containing ‘source-holes’ as ports, rearranges the fluid into ordered tree-like networks. Reshaping is an outcome of ‘Saffman-Taylor interface instability’ induced by the displacement of a high-viscous fluid by a relatively low-viscous one in the cell. A new configuration of ‘source-holes’, is proposed here to control the instability towards shaping of high-viscous fluid into ordered multiscale treelike layouts. The process is lithography-less method of shaping the fluid spontaneously into 3D layouts in a very short interval of time. Fabricated structures are UV-cured and cast into channel-networks in an elastomer PDMS.
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Klein, Steven A., Aleksandar Aleksov, Vijay Subramanian, Rajendra Dias, Pramod Malatkar, and Ravi Mahajan. "Mechanical Testing for Stretchable Electronics." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-68215.

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Stretchable electronics have been a subject of increased research over the past decade [1–3]. Although stretchable electronic devices are a relatively new area for the semiconductor/electronics industries, recent market research indicates the market could be worth more than 900 million dollars by 2023 [4]. At CES (Consumer Electronics Show) in January 2016, two commercial patches were announced which attach to the skin to measure information about the user’s vitals and environmental conditions [5]. One of these measures the sun exposure of the user with a UV sensitive dye — which can communicate with the user’s cell phone to track the user’s sun exposure. Another device is a re-usable flexible patch which measures cardiac activity, muscle activity, galvanic skin response, and user’s motion. These are just two examples of the many devices that will be developed in the coming years for consumer and medical use. This paper investigates mechanical testing methods designed to test the stretching capabilities of potential products across the electronics industry to help quantify and understand the mechanical integrity, response, and the reliability of these devices. Typically, the devices consist of stiff modules connected by stretchable traces [6]. They require electrical and mechanical connectivity between the modules to function. In some cases, these devices will be subject to bi-axial and/or cyclic mechanical strain, especially for wearable applications. The ability to replicate these mechanical strains and understand their effect on the function of the devices is critical to meet performance, process and reliability requirements. There has been a test method proposed recently for harsh / high-rate testing (shock) of stretchable electronics [7]. The focus of the approach presented in the paper aims to simulate expected user conditions in the consumer and medical fields, whereas earlier research was focused on shock testing. In this paper, methods for simulating bi-axial and out-of-plane strains similar to what may occur in a wearable device on the human body are proposed. Electrical and / or optical monitoring (among other methods) can be used to determine cycles to failure depending on expected failure modes. Failure modes can include trace damage in stretchable regions, trace damage in functional component regions, or bulk stretchable material damage, among others. Three different methods of applying mechanical strain are described, including a stretchable air bladder method, membrane test method, and lateral expansion method. This work will describe a prototype of the air bladder method with initial results of the testing for example devices. The system utilizes an expandable bladder to roughly simulate the expansion of muscles in the human body. Besides strain and # of cycles, other variables such as humidity, temperature, ultraviolet exposure, and others can be utilized to determine their effect on the mechanical and electrical reliability of the devices.
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Fartyal, Neeraj Singh, Himanshu Marwah, and Sreenath Balakrishnan. "A Compliant Micromechanism for Biaxially Stretching Biological Cells." In ASME 2021 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/detc2021-68421.

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Abstract Biological cells are known to respond to mechanical forces. Diverse biological phenomena such as tissue development and cancer are regulated by mechanical forces acting on cells. One such mechanical loading found in various tissues such as alveoli, pericardium, blood vessels, and urinary bladder is biaxial stretching. To study the effect of such a loading pattern, it is necessary to develop mechanical tools that can apply controlled biaxial stretching on cells. Here we present the design for such a device, a compliant micromechanism for biaxially stretching single cells. We first designed a compliant, double-input, biaxial stretching mechanism based on re-entrant structures. Various stretch ratios, defined as the ratio between deformations in orthogonal directions, could be obtained by changing the dimensions of this mechanism. Next, we derived an analytical expression relating the geometric parameters to the stretch ratio. This analytical expression was verified using finite element analysis. By numerically solving this expression, multiple designs for a desired stretch ratio were obtained. Furthermore, we converted our design into a single-input mechanism by coupling the double-input biaxial stretcher to a single-input gripper mechanism. Finally, we demonstrate the functioning of our design using a macroscale, 3D-printed version.
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Cheng, Chao-Min, Robert L. Steward, Danny L. Wang, and Philip R. LeDuc. "Effects of Mechanical Strain on Syndecan-4, Focal Adhesion Complexes, and Site-Specific FAK Phosphorylation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192360.

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Cellular mechanics involves the ability of cells to sense and respond to external forces. The type of deformations that cells undergo such as stretching, compression or shearing depends on physiological conditions such as how muscle deforms during movement. Using a custom fabricated stretching device, we focused on investigating how statically applied mechanical stretch affects syndecan-4, focal adhesion complexes and phosphorylated focal adhesion kinase (p-FAK). These results have potential implications in a variety of fields including biophysics, mechanotransduction, and cellular structure.
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