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Dissertations / Theses on the topic 'Cell spreading'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 January 2023

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1

Treloar, Katrina K. "Mathematical models for collective cell spreading." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/86960/1/Katrina_Treloar_Thesis.pdf.

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Collective cell spreading is frequently observed in development, tissue repair and disease progression. Mathematical modelling used in conjunction with experimental investigation can provide key insights into the mechanisms driving the spread of cell populations. In this study, we investigated how experimental and modelling frameworks can be used to identify several key features underlying collective cell spreading. In particular, we were able to independently quantify the roles of cell motility and cell proliferation in a spreading cell population, and investigate how these roles are influenc
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2

Promwikorn, Waraporn. "Regulation of gene expression and cell cycle progression by cell shape." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250316.

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3

Jin, Hua. "The role of Abl tyrosine kinase in cell spreading." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3274697.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed October 5, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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4

Streicher, Pia. "Studying integrin-mediated cell spreading using a biomimetic system." Paris 6, 2008. http://www.theses.fr/2008PA066668.

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L'adhésion cellulaire dépendant des intégrines a été étudiée grâce à un système modèle réaliste. Nous avons développé une méthode basée sur celle initialement mise au point pour d'autres protéines dans l'équipe de P. Bassereau. Elle consiste à reconstituer l'intégrine αIIbβ3 dans des protéoliposomes (0. 1 -0. 2 µm de diamètre), puis à électroformer les vésicules géantes à partir des protéoliposomes partiellement séchés. Le succès de la reconstitution a été vérifié en analysant l'incorporation de la protéine et son activité biologique. La dynamique de l'adhésion ces vésicules sur des surfaces c
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Vo, Brenda. "Novel likelihood-free Bayesian parameter estimation methods for stochastic models of collective cell spreading." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/99588/1/Brenda_Vo_Thesis.pdf.

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Biological processes underlying skin cancer growth and wound healing are governed by various collective cell spreading mechanisms. This thesis develops new statistical methods to provide key insights into the mechanisms driving the spread of cell populations such as motility, proliferation and cell-to-cell adhesion, using experimental data. The new methods allow us to precisely estimate the parameters of such mechanisms, quantify the associated uncertainty and investigate how these mechanisms are influenced by various factors. The thesis provides a useful tool to measure the efficacy of medica
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Redmann, Anna-Lena. "Kinetics of cell attachment and spreading on hard and soft substrates." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290385.

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A very important aspect for the functioning of an organism is that cells adapt their behaviour to external stimuli. They continuously interact with their environment, and biochemical and physical cues can activate cellular signalling, which leads to changes in cell behaviour such as proliferation and shape. Understanding cells' interactions with their environment is also important for understanding diseases. For example mechanosensing, which is the sensing of the cell's mechanical environment, has been associated with cancer development. In order for a cell to be able to sense its mechanical e
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Moore, Edward Andrew. "Cell attachment and spreading on physical barriers used in periodontal guided tissue regeneration /." Oklahoma City : [s.n.], 2002. http://library.ouhsc.edu/epub/theses/Moore-William-A.pdf.

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8

Gill, Amritpal Singh. "Development of a Novel Single-Cell Attachment and Spreading Platform Utilizing Fused-Fiber Nanonets." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/73504.

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Initial attachment to the extracellular matrix (ECM) and consequent spreading is a necessary process in the cell cycle of which little is known. Cell spreading has been well-recognized in 2D systems, however, the native fibrous ECM presents cells with 3D biophysical cues. Thus, using suspended fibers as model systems, we present the development of a novel platform (Cell-STEPs) capable of capturing cell attachment dynamics and forces from the moment a cell in suspension contacts the fiber. Cell-STEPs comprises of a custom glass-bottom petri dish with a lid to deliver a constant supply of CO2
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9

Messmer-Blust, Angela F. "Murine Guanylate-Binding Protein-2: An interferon-induced GTPase that inhibits cell adhesion, cell spreading and MMP-9 expression." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1263394455.

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10

Tse, Kathy Wan-Kei. "The role of Pyk2 and FAK in B cell migration, adhesion, and spreading." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/25041.

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The ability of the B cell receptor (BCR) to stimulate integrin-mediated adhesion, and induce cytoskeletal reorganization and cell spreading enhances the ability of B cells to bind and respond to antigens (Ag). The proper localization and trafficking of B cells in the secondary lymphoid organs are also critical for B cells to encounter Ags and to be activated. Proline-rich tyrosine kinase (Pyk2) and focal adhesion kinase (FAK) are related cytoplasmic tyrosine kinases that have been shown to regulate cell adhesion, morphology, and migration. However, their functions in B cells are not clear.
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Mearns, Bryony Megan BABS UNSW. "Transglutaminase II: an integrator of fibroblast adhesion pathways in wound healing." Awarded by:University of New South Wales. BABS, 2006. http://handle.unsw.edu.au/1959.4/24166.

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Transglutaminase II (TG2) is a complex protein with five different reported activities. Increases in TG2 expression and TGase activity have previously been observed during wound healing in rat studies; however, it has been unclear whether these phenomena were directly involved in the healing process or if they were simply a by-product of it. The aims of this thesis were, thus, to determine if TG2 plays a role in wound healing in vivo and to elucidate the mechanism of any effects TG2 may have at the cellular level. TG2 ablation resulted in delayed wound healing. To gain mechanistic insight
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12

Ferro, Valerie Anne. "The role of endothelial cells in promoting adhesion, spreading and migration of B16F10 cells." Thesis, University of St Andrews, 1989. http://hdl.handle.net/10023/14067.

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For the successful establishment of secondary tumours, blood-borne metastatic tumour cells must adhere and spread on the vascular endothelium before they can migrate through it to form secondary growths in the tissue beneath. In this study an in vitro assay was developed to study the behavourial interactions between B16F10 cells and Bovine aortic endothelial cells. It was hypothesized that molecules synthesized by the endothelial cells may be involved in the mediation of the adhesion, spreading and migration events and hence that such molecules may possibly be involved in the process of haemat
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13

Kovari, Daniel T. "Investigations of the spreading and closure mechanisms of phagocytosis in J774a.1 macrophages." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54882.

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Phagocytosis is the process by which cells engulf foreign bodies. It is the hallmark behavior of white blood cells, being the process through which those cells ingest and degrade pathogens and debris. To date a large amount of research has focused on documenting the existence and role of biochemical components involved with phagocytosis. Scores of signaling molecules have been implicated in the complex signal cascade which drives the process. These molecules are small (typically no larger than 5 nanometers) and operate in a crowded, chemically “noisy,” environment, yet they coordinate the cell
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14

Sasse, Ramona [Verfasser], and Benedikt [Akademischer Betreuer] Wirth. "Mutual information based parameter extraction for spreading cell colonies / Ramona Sasse ; Betreuer: Benedikt Wirth." Münster : Universitäts- und Landesbibliothek Münster, 2021. http://d-nb.info/1240763557/34.

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15

Lai, Jacqueline Cheuk-Yan. "Involvement of CD45 in early thymocyte development." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/3416.

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CD45 is a protein tyrosine phosphatase that is expressed on all nucleated hematopoietic cells. The major substrates of CD45 in thymocytes and T cells are the Src family kinases Lck and Fyn. The role of CD45 in thymocyte development and T cell activation via its regulation of Src family kinases in T cell receptor signaling has been studied extensively. However, the role of CD45 in processes that affect thymocyte development prior to the expression of the T cell receptor has not been explored. The overall hypothesis of this study was that CD45 is a regulator of spreading, migration, prolifera
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16

Xu, Feng, Satoko Ito, Michinari Hamaguchi, and Takeshi Senga. "Disruption of Cell Spreading by the Activation of MEK/ERK Pathway is Dependent on AP-1 Activity." Nagoya University School of Medicine, 2010. http://hdl.handle.net/2237/14175.

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17

Hinoue, Atsushi. "Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cell cultured in vitro." Kyoto University, 2005. http://hdl.handle.net/2433/144698.

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18

Zeller, Kathrin Stephanie. "Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170267.

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Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. These complex cellular responses involve processes such as cell attachment, spreading, and various signaling pathways, which in turn depend on the composition of the extracellular environment, on its mechanical properties, and involved integrin types. This thesis focuses on identifying molecules that signal downstream of integrins and how integrin-induced signals may differ
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19

Huang, Yunjie. "ADP-RIBOSYLATION FACTOR 6 (ARF6) REGULATES INTEGRIN αIIbβ3 TRAFFICKING, PLATELET SPREADING, AND CLOT RETRACTION". UKnowledge, 2015. http://uknowledge.uky.edu/biochem_etds/20.

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Endocytic trafficking of platelet surface receptors plays a role in the accumulation of granule cargo (i.e. fibrinogen and VEGF) and thus could contribute to hemostasis, angiogenesis, or inflammation. However, the mechanisms of platelet endocytosis are poorly understood. The small GTP-binding protein, ADP-ribosylation factor 6 (Arf6), regulates integrin trafficking in nucleated cells; therefore, we posited that Arf6 functions similarly in platelets. To address this, we generated platelet-specific, Arf6 knockout mice. Arf6-/- platelets had a storage defect for fibrinogen but not other cargo, im
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20

Stefansson, Anne. "Mechanisms of Integrin Signal Transduction." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8221.

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<p>Integrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. They have no intrinsic kinase activity; instead the signals are transduced through conformational changes. </p><p>In this thesis, work is presented which is focused on molecular mechanisms of integrin signal transduction. The signal transduction was first studied from a structural point of view, determini
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21

Schuler, Jeffrey Thomas. "Forward Chemical Genetics Drug Screen Yields Novel Proteases and Proteolytic Inhibitors of HGF–induced Epithelial–Mesenchymal Transition." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6257.

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Hepatocyte Growth Factor (HGF)–induced Epithelial–Mesenchymal Transition (EMT) is a complex cellular pathway that causes epithelial cell scattering by breaking cell–cell contacts, eliminating apical–basal polarity, and replacing epithelial markers and characteristics with mesenchymal markers. Early EMT events include a brief period of cell spreading, followed by cell compaction and cell–cell contact breaks. A forward chemical genetics drug screen of 50,000 unique compounds measuring HGF–induced cell scattering identified 26 novel EMT inhibitors, including 2 proteolytic inhibitors. Here, we sh
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22

Rudnicki, Mathilda Sophia. "Cell sensing on strain-stiffening substrates is not fully explained by the nonlinear mechanical property." Digital WPI, 2012. https://digitalcommons.wpi.edu/etd-theses/216.

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Cells respond to their mechanical environment by changing shape and size, migrating, or even differentiating to a more specialized cell type. A better understanding of the response of cells to surrounding cues will allow for more targeted and effected designs for biomedical applications, such as disease treatment or cellular therapy. The spreading behavior of both human mesenchymal stem cells (hMSCs) and 3T3 fibroblasts is a function of substrate stiffness, and can be quantified to describe the most visible response to how a cell senses stiffness. The stiffness of the substrate material can
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23

Song, Jaekyung Cecilia. "Protein Kinase C-δ and Protein Kinase C-ε Cooperatively Enhance Epithelial Cell Spreading via Transactivation of Epidermal Growth Factor Receptor and Actin-Dependent Phosphorylation of Focal Adhesion-Associated Proteins". Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1132198567.

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Thesis (Ph. D.)--University of Cincinnati, 2005.<br>Title from electronic thesis title page (viewed Sept. 13, 2007). Includes abstract. Keywords: Protein Kinase C; Cell spreading; Cell migration; Epithelial Cells; Epidermal Growth Factor Receptor; Transactivation; Focal Adhesion; Actin; Focal Adhesion Kinase; Src; Paxillin Includes bibliographical references.
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24

Hatzikirou, H., K. Böttger, and A. Deutsch. "Model-based Comparison of Cell Density-dependent Cell Migration Strategies." Cambridge University Press, 2015. https://tud.qucosa.de/id/qucosa%3A39048.

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Here, we investigate different cell density-dependent migration strategies. In particular, we consider strategies which differ in the precise regulation of transitions between resting and motile phenotypes. We develop a lattice-gas cellular automaton (LGCA) model for each migration strategy. Using a mean-field approximation we quantify the corresponding spreading dynamics at the cell population level. Our results allow for the prediction of cell population spreading based on experimentally accessible single cell migration parameters.
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25

Wilson, Cameron. "Mediation of Osteoblast Responses to Titanium Roughness by Adsorbed Proteins." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16096/.

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Stable fixation of implants such as artificial teeth depends on the direct apposition of bone to the implanted material. While endosseous implants were traditionally allowed to "osseointegrate" over several months without carrying load, clinical and experimental data show that prostheses with roughened surfaces allow successful integration when subject to earlier loading and more challenging implant sites. However, to design implant surfaces for an optimal biological response requires an understanding of the mechanism by which roughened surfaces promote osseointegration. Research into this me
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Wilson, Cameron John. "Mediation of Osteoblast Responses to Titanium Roughness by Adsorbed Proteins." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16096/1/Cameron_Wilson_Thesis.pdf.

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Stable fixation of implants such as artificial teeth depends on the direct apposition of bone to the implanted material. While endosseous implants were traditionally allowed to "osseointegrate" over several months without carrying load, clinical and experimental data show that prostheses with roughened surfaces allow successful integration when subject to earlier loading and more challenging implant sites. However, to design implant surfaces for an optimal biological response requires an understanding of the mechanism by which roughened surfaces promote osseointegration. Research into this me
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Willett, Mark. "Investigating the localisation and trafficking of the mammalian eIF4F complex in NIH3T3 fibroblasts during cell spreading, adhesion and normal growth conditions." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437454.

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28

Sandmann, Rabea [Verfasser], Sarah [Akademischer Betreuer] Köster, and Florian [Akademischer Betreuer] Rehfeldt. "Blood Platelet Behavior on Structured Substrates : From Spreading Dynamics to Cell Morphology / Rabea Sandmann. Betreuer: Sarah Köster. Gutachter: Sarah Köster ; Florian Rehfeldt." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1078420084/34.

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Nguyen, Beth P. "Integrin alpha 6 beta 4 ligation to laminin 5 and phosphoinositide 3-OH kinase define differences in alpha 3 beta 1-laminin 5 and alpha 2 beta 1-collagen spreading : implications for epidermal wound repair /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9286.

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30

Cavalher, Felicia Peterson. "Caracterização funcional das isoformas de splicing do gene ADAM23." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-10052013-130119/.

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A ADAM23 é uma glicoproteína transmembrana pertencente à família ADAM (A Disintegrin and Metalloprotease) que apresenta a estrutura protéica típica dos membros desta família, mas não possui atividade de metaloprotease. O gene ADAM23 apresenta três isoformas de splicing, &#945;, &#946; e &#947;, que codificam proteínas com porções C-terminais distintas. As isoformas &#945; e &#946; codificam proteínas com domínios transmembranas diferentes, enquanto &#947; provavelmente consiste em uma isoforma secretada ou citoplasmática de ADAM23. Foi demonstrado que o gene ADAM23 está epigeneticamente silenc
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Copley, LaRae. "Investigation of the function of myotubularin through the examination of protein-protein interactions and exclusion of MTMR1 as a frequent cause of X-linked myotubular myopathy." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1080146560.

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32

Venkova, Larisa. "Régulation du volume cellulaire en réponse aux déformations." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS396/document.

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Dans les tissus, les cellules génèrent et sont soumises en permanence à des forces mécaniques. Les perturbations biochimiques à l'intérieur des cellules, ainsi que les altérations de leur environnement mécanique peuvent modifier l'équilibre physiologique et mener à des pathologies, comme le cancer. Bien que les propriétés mécaniques puissent être modifiées à l'échelle du tissus, la compréhension de la mécanique au niveau de la cellule unique demeure importante. En particulier, la différenciation, la migration des cellules immunitaires et le caractère invasif d'un cancer dépendent fortement des
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Gustavsson, Anna. "Effects of invasin and YopH of Yersinia pseudotuberculosis on host cell signaling." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183.

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34

Deveraux, Solenne. "Modélisation de la mécanique de la cellule et son noyau dans le cadre de la migration confinée." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLC063/document.

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Les cellules possèdent une capacitéfondamentale à leur survie : la migration. Del’embryogénèse aux métastases tumorales, lorsde la migration, les cellules doivent se faufiler àtravers des mailles sub-nucléaires pour atteindreleur localisation cible. Pour ce faire, ellespeuvent adapter leur mode locomotion ou leurspropriétés mécaniques à l’environnement quiles entoure. La cellule ainsi que son noyausubissent d’importantes déformations lors de lamigration en milieu confiné. Le noyau étantl’organelle le plus gros et le plus rigide, il peutlimiter la capacité migratoire de la cellule. Sespropriété
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Monteiro, Eric. "Contributions aux méthodes numériques pour traiter les non linéarités et les discontinuités dans les matériaux hétérogènes." Phd thesis, Université Paris-Est, 2010. http://tel.archives-ouvertes.fr/tel-00601050.

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Motivé par l'étude de tissus biologiques, ce travail contribue aux développements d'outils numériques permettant de prédire la réponse mécanique de matériaux hétérogènes non linéaires dans lesquels les énergies d'interfaces deviennent prépondérantes. Ainsi, une méthode d'homogénéisation multi échelle combinée à une technique de réduction de modèle basée sur la décomposition orthogonale aux valeurs propres est proposée dans un cadre thermique et hyperélastique. Les énergies d'interfaces entre les différentes phases des composites sont décrites par un modèle d'interface cohérent et prises en com
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36

Salazar, Montano Ylia [Verfasser]. "Microenvironmental Th9 and Th17 lymphocytes induce epithelial-mesenchymal transition in lung cancer cells thereby promoting metastatic spreading / Ylia Maria Salazar Montano." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461866/34.

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Salazar, Montano Ylia Maria [Verfasser]. "Microenvironmental Th9 and Th17 lymphocytes induce epithelial-mesenchymal transition in lung cancer cells thereby promoting metastatic spreading / Ylia Maria Salazar Montano." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461866/34.

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Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.

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Traumatic brain injury (TBI) is a leading cause of disability worldwide. Annually, 150 to 200/1,000,000 people become disabled as a result of brain trauma. Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. Molecular pathways underlying the pathology of TBI have not been defined and there is no efficacious treatment for TBI. Despite this significant societal impact, surprisingly little is known about the molecular mechanisms that actively drive axon degeneration in any context and particularly followi
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Holmqvist, Kristina. "The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3943.

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<p>Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. Angiogenesis is initiated by binding of specific growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), to their cell surface receptors. Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors. My aim has been to identify the role of Shb in FGF- and VEGF-signalling in e
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Abounit, Saïda. "Molecular and cellular mechanism of α-synuclein assemblies transfer between neuronal cells : role of Tunneling nanotubes". Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112063.

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Les synucléionopathies représentent un groupe de maladies neuro-dégénératives incurables du système nerveux central. Elles regroupent entre autres la maladie de Parkinson, l’atrophie multi-systématisée et la maladie à corps de Lewy. Toutes ces maladies se caractérisent par un déclin progressif des fonctions motrices, cognitives, comportementales et autonomiques. La mal-conformation et l’agrégation de la protéine α-synuclein qui forme des inclusions intraneuronales sont des éléments communs à toutes les synucleinopathies. Ces inclusions portent le nom de corps de Lewy et se forment dans des neu
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廖乾廷. "numerical simulation of cell spreading and protrusion." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/43941693301365920356.

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Choo, Lai Mun, and 朱麗雯. "The function of human MOB2 in cell spreading in fibrosarcoma cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/40238958167824388773.

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碩士<br>東海大學<br>生命科學系<br>99<br>Cell spreading is an initial mechanism for cell migration which plays a vital role in cancer development. Cell spreading has been shown to act as one of the key regulating steps between static and metastatic transition of a cancer cell. Hence, by identifying regulatory networks controlling cell spreading, it may provide valuable information and therapeutic strategies for preventing tumor metastasis. Both cell spreading and cell migration involve actin polymerization at the leading edge of plasma membrane follow by cell retraction at the rear end of cells. The molec
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Tu, Hsin-Mou, and 杜信謀. "Finite Element Analysis of Bio-cell Spreading and Phagocytosis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/74476416189886343995.

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Cheng-EnLu and 呂承恩. "Routability-Driven Post-Optimization of Placement Using Cell Spreading Technique." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/59839231735619670683.

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Wong, Nelson Kwan Yin. "CD44 signaling in T cells leading to cell spreading and its regulation by CD45." Thesis, 2006. http://hdl.handle.net/2429/18417.

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CD44 is a widely expressed adhesion molecule that has been implicated in mediating cellular signaling. In this dissertation, the signaling pathway initiated by CD44 that leads to actin rearrangement and cell spreading in T cells was studied. The results indicate that engagement of CD44 leads to actin-dependent clustering of this adhesion molecule. CD44 clustering then initiates the recruitment of signaling proteins, including the Src-family kinases (SFK) Lck and Fyn, phosphatidylinositol-3 kinase (PI3K), and non-receptor related focal adhesion kinase Pyk2. The outcome of actin rearrangem
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Hsiu-MeiChen та 陳秀梅. "The Role of Integrin-β1 in Leiomyomal Cell Spreading and Proliferation". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/7a65eq.

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博士<br>國立成功大學<br>基礎醫學研究所<br>101<br>Uterine leiomyoma is a benign tumor derived from uterine smooth muscle layer. It is one of the most common gynecological diseases in women of reproductive age. Symptoms of leiomyoma include pelvic pressure, abnormal uterine bleeding, and infertility. Due to the presence of excessive amount of extracellular matrix (ECM), leiomyoma is also called fibroid. Besides contributing to the huge volume in leiomyoma, ECM may play an important role in the development of leiomyoma. Integrins are the major ECM-receptor on cell surface. Binding of ECM to integrins leads to c
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47

Chen, Ying-Ti, and 陳映荻. "Evidence for the Involvement of Thrombomodulin in Cell Spreading and Migration." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/87516128485901231231.

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碩士<br>中國醫藥大學<br>醫學檢驗生物技術學系碩士班<br>98<br>Thrombomodulin（TM）, a cell surface-expressed glycoprotein, is critical for thrombin-mediated activation of protein C. Recent evidence has revealed that TM also has protein C- and thrombin-independent physiological function. In this study, we found that depletion of TM could regulate the morphology of the human keratinocyte cell line, HaCaT. These cells showed an enhanced migratory activity. Phalloidin staining revealed that TM-knockdown induced lamellipodia protrusion at the free edges of colonies. To investigate the mechanism of TM regulated the cytoskel
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Chang, Chu-Lung, and 張主龍. "L-Caldesmon Dependent Mechanical Changes of Cell Spreading and Adhesion Force in Osteoclastogenesis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/84570975147666939765.

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碩士<br>國立中興大學<br>生命科學系所<br>105<br>Caldesmon (CaD) is an actin regulator, expressing two isoforms in smooth muscle cells (h-CaD) and non-muscle cells (l-CaD), respectively. Both isoforms of CaD are capable of stabilizing actin filaments against actin-severing proteins, inhibiting actomyosin ATPase activity, and inhibiting Arp2/3-mediated actin polymerization. However, little is known about the role of l-CaD in the control of cell-cell fusion in osteoclastogenesis. To determine the functional role of the increased l-CaD expression in osteoclastogenesis, Raw264.7 cells transfected with fusion DNA
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Ferguson, Caroline. "Mechanical Forces Regulate Cartilage Tissue Formation by Chondrocytes via Integrin-mediated cell Spreading." Thesis, 2009. http://hdl.handle.net/1807/19322.

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In vitro grown cartilage is functionally inferior to native tissue, and improvements in its quality should be attempted so it can be used therapeutically. In these studies we investigated the effects of cell shape on tissue quality through alteration of substrate geometry and application of mechanical stimuli. Articular chondrocytes were isolated and cultured on the surface Ti-6Al-4V substrates with various geometries. When cultured on fully porous titanium alloy substrates, chondrocyte spreading was enhanced over those grown on substrates with solid bases. Chondrocytes which remained round
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Bastien, Jayson I. L. "Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6." Thesis, 2012. https://doi.org/10.7916/D8R78N8R.

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Cell migration is an orchestrated and highly coordinated multi-step process that is central to the development and maintenance of multicellular organisms. Dysregulated migration however, is associated with pathological states such as tumor formation and metastasis; thus a clear understanding of the molecular mechanisms that drive this process is critical to the development of counteracting therapeutics. Cell migration and adhesion-dependent cell spreading share a number of features. For example, both processes rely on the activation of mechanisms for the coordinated spatial and temporal assemb
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