Dissertations / Theses on the topic 'Cell receptors – Physiological effect'
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Siwik, Steven Anthony 1963. "Regulation of receptor-mediated phosphatidylinositol hydrolysis in AR42J rat carcinoma cells." Thesis, The University of Arizona, 1989. http://hdl.handle.net/10150/277180.
Full text游燕珍 and Yin-chun Mabel Yau. "Studies on melatonin receptors in guinea pig platelets and melatonin actions on human leukemic megakaryoblast MEG-01 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31242613.
Full text吳毅賢 and Samuel Ng. "Extracellular calcium in dopamine D1-receptor mediated growth hormone release from Chinese grass carp pituitary cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31219755.
Full textBose, Diptiman Dipen. "Role of ryanodine receptors in neuronal calcium signalling and growth control." Scholarly Commons, 2002. https://scholarlycommons.pacific.edu/uop_etds/566.
Full textKorpelainen, Eija. "Interleukin -3 receptor expression and function in now-hemopoietic cells /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk84.pdf.
Full textFundytus, Marian Elaine. "Contribution of metabotropic glutamate receptors to opioid dependence." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42034.
Full textWe showed that chronic intracerebroventricular (i.c.v.) administration of selective group II and III mGluR antagonists concurrently with subcutaneous (s.c.) morphine significantly reduced the severity of precipitated withdrawal symptoms. Conversely, acute i.c.v. injection of a selective group II mGluR antagonist just prior to the precipitation of withdrawal significantly exacerbated the severity of abstinence symptoms. In addition, acute i.c.v. injection of a selective group II mGluR agonist just prior to the precipitation of withdrawal significantly reduced abstinence symptoms. From these results we hypothesized that chronic opioid treatment may induce a desensitization of group II mGluRs.
We also demonstrated that chronic i.c.v. infusion of a selective group I mGluR antagonist concurrently with s.c. morphine significantly attenuated the precipitated withdrawal syndrome. In addition, we showed that chronic i.c.v. antagonism of $ delta$-opioid receptors with a highly selective antagonist also decreased the development of morphine dependence, as well as tolerance. Since both group I mGluRs and $ delta$-opioid receptors are positively coupled to PI hydrolysis, further evidence for a role of products of PI hydrolysis in the development of morphine dependence was obtained when we showed that selective chronic inhibition of protein kinase C (PKC) activation, as well as selective chronic inhibition of intracellular Ca$ sp{2+}$ release, concurrently with morphine treatment significantly reduced the severity of abstinence symptoms. Thus, compensatory changes usually elicited by chronic opioid treatment may be counteracted by antagonizing receptors positively coupled to PI hydrolysis, as well as by inhibiting products of PI hydrolysis.
In the General Discussion, we propose a model based on the possible interaction of mGluRs and opioid receptors, via related intracellular second messengers, to explain the development of morphine dependence.
Mendelson, Scott Douglas. "Differential roles of serotonin receptor subtypes in the modulation of lordosis behaviour in the female rat." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29021.
Full textArts, Faculty of
Psychology, Department of
Graduate
Marsicano, Giovanni. "Physiological role of the cannabinoid receptor 1 (CB1) in the murine central nervous system." n.p, 2000. http://ethos.bl.uk/.
Full textHerrera, Yelenis. "Modulation of ASIC1a Function by Sigma-1 Receptors: Physiological and Pathophysiological Implications." [Tampa, Fla.] : University of South Florida, 2009. http://digital.lib.usf.edu/?e14.2855.
Full textTrout, Amanda L. "SEX DIFFERENCES IN CELL DEATH AND STEROID HORMONE RECEPTORS IN CORTICAL EXPLANTS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/6.
Full textBeauglehole, Anthony Robert, and anthony@adenrx com. "N3-substituted xanthines as irreversible adenosine receptor antagonists." Deakin University. School of Biological and Chemical Sciences, 2000. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20080612.084330.
Full textWoo, Man-man Michelle, and 胡文文. "The effect of melatonin on human luteal cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223746.
Full textSadideen, Doraid, and Doraid Sadideen. "Exploring G-Protein-Coupled Receptors Regulation, Specificity and Controllability of Exosomes Release in the Neuronal Cell Line SH-SY5Y." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621166.
Full textYamamura, Soichiro. "Mechanism of physiological function of sphingosine-1-phosphate : extracellular action and demonstration of alleged receptor /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9278.
Full textKasten, Chelsea Rae. "Intra-nucleus accumbens shell injections of R(+)- and S(-)- baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice." Thesis, Behavioural Brain Research (Elsevier), 2014. http://hdl.handle.net/1805/6453.
Full textIt has been proposed that the GABAB receptor subtype plays a role in alcoholism and alcohol use disorders (AUDs) (Cousins et al., 2002; Agabio et al., 2012). Specifically, the GABAB agonist baclofen has been looked at extensively in clinical and pre-clinical studies. In various animal models of chronic and intermittent consumption, baclofen has been shown to both increase (Petry, 1997; Smith et al., 1999; Czachowski et al., 2006; Moore et al., 2007) and decrease (Colombo et al., 2000; 2002; 2005; Stromberg, 2004; Moore et al., 2009) drinking. A critical issue in determining pharmacological effects of a drug is using the appropriate animal model. The drinking-in-the-dark (DID) model, developed by Rhodes et al. (2005, 2007), produces high levels of drinking in a binge-like paradigm and has been used to assess many pharmacological targets (e.g. Kamdar et al., 2007; Gupta et al., 2008; Moore et al., 2007; 2009). While DID produces high-levels of binge drinking, it is unclear what areas of the brain are involved in this behavior. A direct way to target areas that are believed to be involved in the circuitry of particular behaviors is through microinjection of drugs (Kiianmaa et al., 2003). Of particular recent interest involving motivated behaviors and addiction is the nucleus accumbens (Acb) (Everitt & Robbins, 2005); specifically the accumbens shell (AcbSh) (e.g. Rewal et al., 2009, 2012; Nie et al., 2011; Leriche et al., 2008). The current study aimed to investigate the role of GABAB receptors in the AcbSh by examining the ability of two different enantiomers of baclofen to alter ethanol and saccharin intake in male C57BL/6J (B6) mice. B6 mice underwent bilateral cannulation surgery targeting the AcbSh. After 48 hours of recovery time, animals began a five day Drinking-in-the-Dark (DID) procedure where they received 20% ethanol or 0.2% saccharin for two hours, three hours into the dark cycle, each day. Throughout the five drinking sessions, animals were kept in home-cage locomotor activity chambers to monitor activity throughout the drinking cycle. Day 4 drinking was immediately preceded by a mock microinjection, whereas Day 5 drinking was immediately preceded by a drug microinjection. Microinjection of one of five doses of baclofen was given in ng/side dissolved in 200 µl of aCSF (aCSF alone, 0.02 R(+)-, 0.04 R(+)-, 0.08 S(-)-, or 0,16 S(-)-). Intake was recorded every twenty minutes on Days 4 and 5. Retro-orbital sinus blood samples were taken from ethanol animals immediately following the Day 5 drinking period to determine blood ethanol concentrations (BECs). A one-way ANOVA on total Day 4 ethanol consumption revealed no baseline differences between dose groups. A one-way ANOVA on total Day 5 ethanol consumption revealed that the 0.04 R(+)- baclofen dose reduced total drinking, but the 0.16 S(-)- baclofen dose increased total drinking (p’s<0.05). This pattern was reflected in the BECs; 0.04 R(+)- baclofen reduced BECs, whereas 0.16 S(-)- baclofen increased BECs (p’s<0.05). These results were also time-dependent, with R(+)-baclofen reducing drinking in the first 20 minutes of the session and S(-)- increasing drinking in the last 40 minutes of the session. There were no effects on saccharin intake. An issue with the locomotor activity boxes led to unreliable locomotor activity counts. However, because there were no drug effects on saccharin consumption, it was concluded that locomotor effects did not contribute to the decreases or increases in ethanol consumption. These results further implicate the role of GABAB receptors in modulating ethanol intake. The bidirectional effects shown highlight the importance of considering enantioselective drug effects when interpreting data. Finally, these results also support previous conclusions that the AcbSh plays an important role in modulating use of drugs of abuse, but not other reinforcers.
Amend, Diane Lisa 1964. "The effect of pentylenetetrazol kindling on the somatostatin cell population in the rat hippocampus." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/278383.
Full textIdrus, Nirelia, and n/a. "Investigation of cerebellar cell death after ethanol exposure during development." University of Otago. Department of Anatomy & Structural Biology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071127.162052.
Full textHoldcraft, Robert Wesley. "Regulation of spermatogenesis by androgen receptor : effect of hypomorphic and cell-specific mutations /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10249.
Full textLuk, Hui Ying. "Effect of the Resistance Exercise-Induced Hormonal Changes on Satellite Cell Myogenic State." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157528/.
Full textLi, Yiming. "Ryanodine receptors in calcium signaling pathways." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/710.
Full textCui, Rui. "The role of Ryanodine receptors in neuronal calcium signaling." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/705.
Full textMattern, Janet. "Muscarinic Receptor Modulation of the Phospholipid Effect in Cardiac Myocytes." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc500469/.
Full textDeering, Susan. "The effect of overexpressing prolactin receptors on cell proliferation and milk protein synthesis in a bovine mammary epithelial cell line." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ50752.pdf.
Full textDeering, Susan. "The effect of overexpressing prolactin receptors on cell proliferation and milk protein synthesis in a bovine mammary epithelial cell line /." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21538.
Full textIt was found that the growth rate of parental cells was depressed in the presence of 5 mug/ml of PRL. In contrast, the growth rate of the transfectants was enhanced by the addition of 5 mug/ml PRL to the culture medium. In addition, both "SP" and "S15" cells produced higher levels of STAT5 upon long-term (48 h) PRL stimulation. No effect on the synthesis of alpha S1- and beta-caseins was noted. It is likely that no differences in protein synthesis were observed because the cells have lost the ability to differentiate, even when cultured on collagen gels in the presence of lactogenic hormones.
Klipp, Robert Carl. "Catecholamine Interactions with the Cardiac Ryanodine Receptor." PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1439.
Full textShanmugam, Vijayalakshmi. "Characterization of osteopontin in RSV transformed rat-1 cells and its role in cell transformation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0005/NQ37025.pdf.
Full textOng, Jennifer. "GABA and GABA-receptors in the enteric nervous system /." Title page, contents and summary only, 1985. http://web4.library.adelaide.edu.au/theses/09PH/09pho582.pdf.
Full textEager, Blenerhassit Edward. "The modulating effect of sildenafil on cell viability and on the function of selected pharmacological receptors in cell cultures / B.E. Eagar." Thesis, North-West University, 2004. http://hdl.handle.net/10394/611.
Full textThesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2005.
Stein, Melissa Marie. "Humoral and T cell immune responses to model antigen delivered with biomaterials used in tissue engineering." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/20175.
Full textWang, Hongying, and 汪紅英. "Studies on the mechanisms of cigarette smoke-induced apoptosis and cell proliferation in gastric epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3124113X.
Full textBECKMANN, M. PATRICIA. "SYNTHESIS AND OLIGOSACCHARIDE PROCESSING OF NORMAL AND ALTERED IMMUNOGLOBULIN M DURING B-CELL DIFFERENTIATION (GLYCOPROTEIN, GLYCOPEPTIDE, MUTANT, CARBOHYDRATE, ASPARAGINE-LINKED)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187906.
Full textHoong, Isabelle Yoke Yien. "Expression of 11β-hydroxysteroid dehydrogenases in mice and the role of glucocorticoids in adipocyte function." Monash University, Dept. of Biochemistry and Molecular Biology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9473.
Full textWong, Tin Lok. "Mechanism of action of silicon in cell signalling." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709339.
Full textWhittington, John. "Physiological effects of salinity on chara corallina /." Title page, contents and summary only, 1990. http://web4.library.adelaide.edu.au/theses/09PH/09phw6258.pdf.
Full textChen, Jianping. "The Effects of Chronic Ethanol Intake on the Allosteric Interaction Between GABA and Benzodiazepine at the GABAA Receptor." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc501231/.
Full textShao, Zuoyi. "The effect of polyamine amide toxins and polyamines in nicotinic acetylcholine receptors of the TE671 cell line." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338532.
Full textJudkins, Courtney Peta. "Pharmacological characterisation of relaxin and the relaxin receptor." Monash University, Dept. of Pharmacology, 2004. http://arrow.monash.edu.au/hdl/1959.1/9497.
Full textDeo, P. "Effect of Food-Derived Advanced Glycation Endproducts on Receptors and Markers of Oxidative Stress in Human Cell Lines." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501257.
Full textSchroeder, Jan-Hendrik. "Adherence of microfilariae of the filarial nematode Brugia malayi to human endothelial cells and their effect on human endothelial cell mediated immune responses." Thesis, Royal Veterinary College (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558986.
Full textRider, Mark Sterling. "Effect of Cell-Specific, Music-Mediated Mental Imagery on Secretory Immunoglobulin A (sIgA)." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc331777/.
Full textChow, Ka-man. "The antioxidant effect of lycium fruit extract on hyperglycemia-induced oxidative stress in human liver and rat muscle cell lines." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B36186132.
Full textVingren, Jakob L. "Effect of Chronic Alcohol Abuse and Resistance Training on the Skeletal Muscle Androgen Receptor Concentration of Rats." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4540/.
Full text黃卓睿 and Cheuk-yui Max Wong. "Role of k-opioid receptor in cardioprotection against stress with coldexposure and restraint or against morphine." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971283.
Full textXia, Yun. "Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3191/.
Full textLee, Sherman. "The effect of acute cigarette smoke exposure on regional pulmonary blood flow, volume, red cell transit and polymorphonuclear leukocyte retention in the rabbit lung." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24840.
Full textPathology and Laboratory Medicine, Department of
Graduate
Franco, Rohini-Ann. "Effect of Estrogen on LPS-induced human endothelial cell adhesion moledule expression and calcium signaling." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/627.
Full textWinter, Lara. "Characterisation of the neurosteroid analgesic alphadolone." Monash University, Dept. of Anaesthesia, 2004. http://arrow.monash.edu.au/hdl/1959.1/9669.
Full textKarhu, T. (Toni). "Isolation of novel ligands for MAS-related G protein-coupled receptors X1 and X2, and their effect on mast cell degranulation." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526216331.
Full textTiivistelmä Syöttösolut on tärkeä osa ihmisen immuunijärjestelmää. Ne ovat tärkeitä tulehdus- ja fysiologistenprosessien säätelijöitä. Syöttösolujen vaikutus välittyy degranulaation ja siinä vapautuvien tulehdusvälittäjäaineiden kautta. Vapautuviin aineisiin lukeutuu esim. histamiini ja lukuisia sytokiinejä, sekä proteaaseja. Syöttösolujen aktivaatio voi tapahtua immunoglobuliineista riippuvaa tai immunoglobuliineista riippumatonta reittiä pitkin. Monet ei-immunologiset tekijät voivat laukaista jälkimmäisen reitin ja kaksi uutta tähän vaikuttavaa G-proteiinikytkentäistä reseptoria on löydetty, MAS-related G protein-coupled receptor X1 (MRGPRX1) ja X2. MRGPRX1:llä ja MRGPRX2:lla on kaksi tunnettua tehtävää: i) ne laukaisevat syöttösolujen degranulaation ja ii) ne osallistuvat kivun ja kutinan aistimiseen tietyissä tuntohermoissa. Näitä reseptoreita ei ilmennetä kaikissa syöttösoluissa, vaan ainoastaa tryptaasia ja kymaasia sisältävissä syöttösoluissa, ja täten osaltaan selittävät syöttösolujen monimuotoisuutta. Useimmista G-proteiinikytkentäisistä reseptoreista poiketen MRGPRX1 ja MRGPRX2 ovat laajakirjoisia, sitoen monia erilaisia ligandeja. Ligandeihin kuuluu endogeenisia neuropeptidejä, antimikrobiaalisia peptidejä ja proteiinin fragmentteja, sekä synteettisiä yhdisteitä kuten erilaisia antibiootteja. Reseptoreiden endogeeniset ligandit voivat toimia laukaisijana jossain syöttösoluihin liittyvissä sairauksissa, degranuloidessaan syöttösoluja ja aiheuttaen paikallisen tulehdustilan. Reseptoreiden laajakirjoisuudesta johtuen niillä on oletettavasti monia vielä tuntemattomia ligandeja. Tämän tutkimuksen tarkoitus oli eristää uusia endogeenisiä ligandeja MRGPRX1:lle ja MRGPRX2:lle ihmisen kudoksista ”kääteisfarmakologista lähestymistapaa” hyödyntäen ja selvittää ligandien kyky syöttösolujen degranulaatioon. Lähtömateriaalina käytetyt ihmisen verihiutaleet ja plasma sisälsivät MRGPRX1:ta ja MRGPRX2:ta aktivoivia yhdisteitä. Plasmasta eristettiin ja sekvensoitiin kolme albumiinin fragmenttia, jotka aktivoivat MRGPRX2:ta. Nämä fragmentit aktivoivat MRGPRX2:ta ja degranuloivat syöttösoluja annosriippuvaisesti. Kaksi MRGPRX1:tä aktivoivaa hemoglobiinin β-ketjun fragmenttia eristettiin ihmisen verihiutaleista. Nämä fragmentit tunnistettiin hemorfiineiksi ja ne aktivoivat MRGPRX1:tä annosriippuvaisesti, mutta eivät vaikuttaneet syöttösolujen degranulaatioon
McKendrick, Joseph James. "Epithelial ovarian cancer cell adhesion to extracellular matrix proteins and the effect on adhesion of peptide inhibitors of adhesion receptors." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316401.
Full textThomas, William James. "60 Hz magnetic field exposure inhibits protein Kinase C dependent induction of Neuropeptide Y mRNA in PC-12 cells." CSUSB ScholarWorks, 1994. https://scholarworks.lib.csusb.edu/etd-project/907.
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