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Dissertations / Theses on the topic 'Cell proliferation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Falk, Anna. "Stem cells : proliferation, differentiation, migration /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-497-X/.

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2

Cheng, Wai. "The relationship between peroxisome proliferator-activated receptors (PPARs) and cell proliferation /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36433937.

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3

Cheng, Wai, and 鄭蔚. "The relationship between peroxisome proliferator-activated receptors (PPARs) and cell proliferation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45010614.

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4

Ashagbley, Anthony J. "Ethanolamine requirement and cell proliferation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23203.pdf.

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5

Hooper, Nigel I. "Methylglyoxal, glyoxalases and cell proliferation." Thesis, Aston University, 1987. http://publications.aston.ac.uk/12548/.

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The metabolic function of the glyoxalase system was investigated in (a) the differentiation and proliferation of human tumour cells in vitro, (b) the cell-free assembly of microtubules and (c) in the red blood cells during hyperglycaemia associated with Diabetes Mellitus. Chemically-induced differentiation of human promyelocytic HL60 leukaemia cells to neutrophils, and K562 erythroleukaemia cells, was accompanied by a decrease and an increase in the activity of glyoxalase I, respectively. Growth-arrest of Burkitt's lymphoma Raji cells and GM892 lymphoblastoid cells was accompanied by an increa

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6

Ellison, David William. "Cell proliferation, cell death, and differentiation in gliomas." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295912.

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7

Petersen, Cecilia. "Paracrine regulation of Sertoli cell proliferation /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-443-7/.

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8

Zhang, Jiao, and 张姣. "Regulation of cell proliferation and modulation of differentiation in human induced pluripotent stem cell-derived mesenchumal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617503.

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Functional mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (iPSCs) may represent an unlimited cell source with superior therapeutic benefits for tissue regeneration to somatic tissue, such as bone marrow (BM)-derived MSC. In the first part of this project, I investigated whether the differential expression of ion channels in iPSC-MSCs was responsible for their higher proliferation capacity than that of BM-MSCs. The expression of ion channels for K+, Na+, Ca2+ and Cl- currents was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The function

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9

Yamak, Fatimah Abir. "GATA4 Partners in Cardiac Cell Proliferation." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23802.

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Cardiovascular diseases are the leading cause of death in humans throughout the world and “congenital heart defects” (CHDs) are the major cause of infant mortality and morbidity. GATA4 is one of the most critical and intensely studied cardiac transcription factor. It is important for proliferation of cardiomyocytes as well as their survival and adaptive response. The focus of the following thesis was to identify GATA4 mediators and cofactors in cardiac growth. The first part focused on cyclin D2 (CycD2), a growth inducible cell cycle protein. We identified Ccnd2 (gene encoding CycD2) as a dire

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10

Cheung, Man-keung, and 張文強. "FBI-1 and choriocarcinoma cell proliferation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193565.

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Gestational trophoblastic disease (GTD) includes a spectrum of diseases that involve abnormal growth of trophoblastic cells inside the uterus. It can range from benign hydatidiform moles (HM) to frankly malignant choriocarcinoma, placental site trophoblastic tumor (PSTT) or epithelioid trophoblastic tumour (ETT).GTD are considered curable if the patient is correctly diagnosed and receive appropriate treatment during the early stage of the disease. About 15% -30% of hydatidiform moles will develop persistent GTD, but majority of them can usually resolved by surgical intervention and post-ope

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11

Dunphy, Elizabeth Louise. "TAF1 HAT activity in cell proliferation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6250.

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12

Roshan, Amit. "Stochasticity and order : studies of keratinocyte proliferation." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/252966.

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A central tenet of stem cell biology has been that proliferating tissues are maintained through a cellular hierarchy comprising of self-renewing stem cells at the apex, multiple lineage-restricted short-lived progenitor cells, and post-mitotic differentiated cells. The wide range of colony sizes in cultured human keratinocytes has been taken to support this hypothesis. Contrary to this model, researchers using genetic lineage tracing in mouse epidermis have inferred a single progenitor population for homeostasis, and a quiescent stem cell population activated upon wounding or genetic mutation.

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13

Kinoshita, Naoko. "REGULATION OF CELL PROLIFERATION USING TISSUE ENGINEERING IN MIN6 CELLS." Kyoto University, 2001. http://hdl.handle.net/2433/150577.

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14

Ryan, John Joseph. "Stem Cell Factor in Mast Cell and Schwann Cell Proliferation and Hyperplasia." VCU Scholars Compass, 1992. https://scholarscompass.vcu.edu/etd/5273.

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Stem cell factor (SCF) is a recently characterized hematopoietic growth factor capable of stimulating the proliferation and differentiation of many hematopoietic cells, including the mast cell. We have cloned the gene encoding SCF from a cDNA library prepared from NIH 3T3 fibroblasts, and have characterized the ability of recombinant SCF to induce the development of mast cell-committed progenitors (MCCP), found in the mesenteric lymph nodes of mice infected with Nippostrongylus brasiliensis (Nb-MLN), but not naive mice. We have also examined Schwann cells, mast cells, and reproductive tissues

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15

Vanhee, Christine. "Influence of shear stress on cell proliferation and on protein kinase C localization in an anchorage-dependent mammalian cell line." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/18866.

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16

Delorme, Marilyne. "Downregulation of ATRX disrupts cell proliferation and cell cycle progression." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27627.

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ATRX is a chromatin remodelling protein of the SNF2 family of chromatin remodelling proteins. Mutations in the ATRX gene have been shown to cause the ATR-X syndrome, an X-linked mental retardation disorder. ATRX is part of a chromatin-remodelling complex with Daxx that localizes to PML nuclear bodies or pericentromeric heterochromatin and is thought to regulate gene expression. In mice, Atrx inactivation results in embryonic lethality whereas conditional forebrain specific Atrx ablation showed impaired development and disorganization of the cortex. Furthermore, ATRX phosphorylation was shown t

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17

Keith, Brooks. "IgE Enhances B Cell-Derived Exosomal Induced T Cell Proliferation." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2909.

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For many years it has been known that the injection of antigen bound to an antibody leads to more than a 1000-fold increase in antigen specific antibody response. This observation holds true for IgE, which is dependent upon CD23 expression, as this enhancement is not present in mice deficient in CD23. It also has been shown that when mice are injected with IgE-antigen complexes also display an increase in antigen specific T cell proliferation. While there are published studies that demonstrate a role for B cell derived exosomes in the activation and proliferation of T cells, none have focuse

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18

Gan, Lisha. "Corneal cellular proliferation and wound healing /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4505-5/.

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19

Apperly, James A. "The relationship between proliferation and differentiation during oligodendrocyte development." Thesis, University College London (University of London), 2001. http://discovery.ucl.ac.uk/1349376/.

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How do precursor cells know when it is time to stop dividing and differentiate? The phenomenon of lineage-specific progenitor cells undergoing a limited period of proliferation prior to terminal differentiation is a common theme in multicellular development. Despite this, little is understood about how these two events are co-ordinated during the normal schedule of development. I have studied the question of how proliferation and differentiation are co-regulated in the oligodendrocyte lineage in the rodent optic nerve. Oligodendrocytes are post-mitotic cells that myelinate axons in the vertebr

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20

Miess, H. "Identification of metabolic genes essential for proliferation of clear cell Renal Cell Carcinoma (ccRCC) cells." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1462468/.

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Kidney cancer accounts for 2-3% of adult malignancies with clear cell renal cell carcinoma (ccRCC) being the most common histological subtype (70-80% of cases). Interestingly, ccRCCs show a highly distinct metabolic phenotype making this disease stand out amongst other cancer types. The underlying causes of the aberrant metabolism in ccRCC are not fully understood, but metabolic transformation could provide novel strategies for targeted therapies in this disease. The pVHL tumour suppressor is located on chromosome 3p21, which is frequently lost in ccRCC. pVHL is a negative regulator of the Hyp

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21

Sutton, Selina Kaye. "How does mitochondrial heteroplasmy affect cell proliferation?" Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/1306.

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Mitochondrial mutations and heteroplasmy have been associated with disease states that result from inadequate cellular energy production. As mitochondrial DNA (mtDNA) encodes many of the polypeptides involved in oxidative phosphorylation (OXPHOS), mtDNA mutations may lower energy production which is required for cell division and sustained ATP synthesis. In order to test the relationship between mtDNA mutations and the rate of cell division, a mammary epithelial cancer cell line, MCF-7, is used as a model. Nine proliferate single cell clones have been isolated from MCF-7. Population dou

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22

Wang, Yanling. "cAMP-Regulated Cell Proliferation in Brown Preadipocytes." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-88393.

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As a prototypical second messenger, cAMP is involved in the regulation of multiple cell functions. cAMP has a well established inhibitory effect on cell proliferation in smooth muscle and epithelial cell types. However, there is accumulating evidence also for stimulatory effect on proliferation, mainly in endocrine cell types. Mechanisms mediating the cAMP stimulatory effect are not well studied. cAMP, produced via β1-adrenoceptor activation, promotes cell proliferation in brown preadipocytes. Due to the importance of brown adipose tissue in energy metabolism and its implication in the treatme

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23

Sohi, Jasloveleen. "Investigation of factors regulating parathyroid cell proliferation." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55530.

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Parathyroid glands are responsible for maintaining normal extracellular calcium concentrations through their release of PTH. Calcium and 1,25-(OH)$ rm sb2D sb3$ have been demonstrated to be potent regulators of PTH and CgA synthesis and release. Primary cultures of quiescent bovine parathyroid cells proliferate in response to high concentrations of serum. Next, I examined the role of c-myc in the proliferation of the PT-r cell line, which was cloned from rat parathyroid cells. In order to study the role of c-myc in PT-r cell proliferation more precisely, I used antisense RNA technology to inhi

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24

Livingstone, D. "Modelling cell proliferation in a structured tissue." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379764.

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25

Goodlad, J. R. "Germinal centre cell proliferation in murine spleens." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241447.

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Germinal centres are dynamic structures in which a number of kinetic processes take place. This thesis was designed to investigate mechanisms whereby one of these kinetic events, germinal centre cell proliferation, is regulated <I>in vivo</I>. In order to achieve this, the proliferative rate of germinal centre cells was measured in C3H/HeN mice under a variety of experimental conditions. In particular, the effect on germinal centre cell proliferation of different classes of antigen and of variously timed doses of the immunosuppressant drug cyclosporin A, was examined. In some experiments, an i

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26

Noordin, Liza. "Molecular mechanisms of cell proliferation in endometriosis." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16808.

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27

Li, Zhaoqi Ph D. Massachusetts Institute of Technology. "Bioenergetics and metabolism of eukaryotic cell proliferation." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130658.

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Thesis: Ph. D. in Biochemistry, Massachusetts Institute of Technology, Department of Biology, February, 2021<br>Cataloged from the official PDF of thesis. "February 2021." Vita. Page 179 blank.<br>Includes bibliographical references.<br>Cellular growth and proliferation necessitates the transformation of cell-external nutrients into biomass. Strategies of biomass accumulation across the kingdoms of life are diverse and range from carbon fixation by autotrophic organisms to direct biomass incorporation of consumed nutrients by heterotrophic organisms. The goal of this dissertation is to better

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28

Jarboe, Daniel Lee. "Proliferation and Differentiation of Mast Cell Progenitors." VCU Scholars Compass, 1988. http://scholarscompass.vcu.edu/etd/4940.

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We have identified a late, committed stage in the differentiation of the mast cell progenitor just prior to granulation. This mast cell-committed progenitor (MCCP) differs from the more primitive bone marrow mast cell progenitor in that it is able to proliferate and differentiate in the absence of interleukin-3 (IL-3) when cultured on a monolayer of embryonic skin or 3T3 fibroblasts. The MCCP can be harvested from the mesenteric lymph nodes of mice in their fourteenth day of infection with the rodent hookworm Nippostrongylus brasiliensis and can be cloned in a methylcellulose culture system by

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29

Perez, Madrigal Diana. "The role of ERK5 in cell proliferation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-erk5-in-cell-proliferation(ee569cda-581d-4698-80c0-84f15fe88f53).html.

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The extracellular signal-regulated protein kinase 5 (ERK5), also known as big mitogen-activated protein (MAP) kinase 1 (BMK1), is a non-redundant mitogen-activated protein kinase (MAPK) implicated in mediating the response of cells to mitogens, oxidative and osmotic stresses. The molecular complexity of the ERK5 cascade has been mostly delineated by over-expression studies. For example, like other MAPKs, ERK5 activity increases upon phosphorylation by a MAPK/ERK kinase, namely MEK5. However, the physiological role of ERK5 is not rigorously established by these data. Furthermore, in comparison

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30

Cavanagh, Brenton. "Investigating Cell Proliferation in the Nervous System." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370820.

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Cell proliferation is a strictly regulated process which is preceded by DNA synthesis and results in an increase in the number of new cells. It is essential for the development, regeneration and is upregulated in tumours. Whilst the study of cell proliferation is fundamental for many arms of biomedical investigation, the techniques used in its study have remained unchanged for decades. Neuroscience is one such field where cell proliferation in the adult can be a rare event and where molecular biology techniques are accelerating discoveries. Unfortunately, the limitations of studying cell proli

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31

TUBITA, ALESSANDRO. "ERK5-dependent mechanisms regulate melanoma cell proliferation." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072181.

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Melanoma is the deadliest skin cancer, with a very poor prognosis in advanced stages. Available treatments for melanoma, especially in its intermediate or advanced stages, are unsatisfactory. ERK5 is a member of the Mitogen-Activated Protein kinase family and regulates cell functions critical for tumor development, such as proliferation, invasion and angiogenesis. In silico data analysis indicated that ERK5 pathway components are upregulated in 47% of human melanomas. On this basis, we hypothesized that ERK5 could play a relevant role in melanoma. To study the possible role of ERK5 in the biol

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32

Browning, Alexander P. "Stochastic mathematical models of cell proliferation assays." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110808/1/Alexander_Browning_Thesis.pdf.

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Cell proliferation assays are routinely used to study collective cell behaviour, and can be interpreted with mathematical models. In this thesis, we apply a computational Bayesian technique to calibrate stochastic discrete mathematical models of cell migration and cell proliferation in the context of a cell proliferation assay. Initially, we use a lattice-based model to explore the optimal duration of a cell proliferation assay. Next, we estimate the parameters in a lattice-free model using three independent experimental data sets. Our model is able to both describe and predict the evolution o

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33

Batsivari, Antoniana. "Studying the cell cycle status during haematopoietic stem cell development." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25802.

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In adults blood stem cells, called haematopoietic stem cells (HSC), give rise to all blood cells throughout life. The origin and biology of HSCs during embryo development has been an intensely studied topic. Definitive HSCs are generated intra-embryonically in the aorta-gonad-mesonephros (AGM) region of the mid-gestation embryo. Recent research revealed that HSCs emerge through multistep maturation of precursors: proHSC → preHSC I → preHSC II → definitive HSC (dHSC). A hallmark of the HSC emergence is the appearance of intra-aortic haematopoietic clusters that are considered to be sites of hae

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34

Li, Jing. "Effects of intrinsic & extrinsic factors on the growth and differentiation of human mesenchymal stem cells." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434450.

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35

Wiklund, Sofia. "Effects on immune cell viability, morphology and proliferation in a sub-microliter cell sampler system." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89982.

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Today, most traditional method used in the research of immune cells, such as flow cytometry and microscopy, are based on average values of cell responses. However, immune cells are heterogeneous and respond differently to a given stimuli. There is also a risk that important, but rare, behaviors of individual cells are missed when a larger population of immune cells is analyzed. Also, flow cytometry and microscopy do not allow long-term survival of cells; these methods lack the ability to do dynamic long-term analysis of motile immune cells, i.e. studies of cell-cell interaction

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36

Harrington, Elizabeth Anne. "Analysis of the molecular regulation of cell proliferation and cell death." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283286.

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37

Herbert, Shane Paul. "Endothelial cell phospholipase Aâ‚‚ : roles in prostaglandin production and cell proliferation." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432387.

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38

Salinas, Daniel Cirera. "miR-33 regulates cell proliferation, cell cycle progression and liver regeneration." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16721.

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Der Cholesterin-Stoffwechsel ist sehr streng auf zellulärer Ebene reguliert und ist essentiell für das Zellwachstum. MicroRNAs (miRNAs), eine Klasse nicht-kodierender RNAs, wurden als kritische Regulatoren der Genexpression identifiziert und entfalten ihre Wirkung vorwiegend auf posttranskriptioneller Ebene. Aktuelle Arbeiten aus der Gruppe um Fernández-Hernando haben gezeigt, dass hsa-miR-33a und hsa-miR-33b, miRNAs die in den Intronsequenzen der Gene für die Sterol-regulatorischen Element- Bindungsproteine (SREBP-2 und SREBP -1) lokalisiert sind, den Cholesterin-Stoffwechsel im Einkl

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39

Chen, Jingbo, and 陳靜波. "Calcium signaling pathways and cell proliferation in human cardiac fibroblast." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290434.

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Chen, Jingbo. "Calcium signaling pathways and cell proliferation in human cardiac fibroblast." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41290434.

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41

Gustincich, Stefano. "Positive and Negative Pathways in Cell Proliferation Control." Doctoral thesis, SISSA, 1992. http://hdl.handle.net/20.500.11767/4206.

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42

Belsey, Mark James. "Osmosensitive taurine release and cell proliferation in neural cells : a pharmacological study." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424410.

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43

Camplejohn, Richard Stephen. "Cell kinetics and cancer." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327272.

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44

Beith, Jennifer Lynn. "The role of insulin on beta-cell proliferation." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/32143.

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A relative decrease in β-cell mass is key in the pathogenesis of type 1 diabetes, type 2 diabetes and in the failure of transplanted islet grafts. It is now clear that β-cell duplication plays a dominant role in the regulation of adult β-cell mass. Knowledge of the endogenous regulators of β-cell replication is therefore critical for understanding the physiological control of β-cell mass and for harnessing this process therapeutically. We have shown that physiological concentrations of insulin act directly on β-cells to promote survival. Whether insulin stimulates adult β-cell proliferat

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45

Fiorini, Federica. "Soft hybrid materials for cell growth and proliferation." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF027/document.

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Le travail de recherche consiste à développer des hydrogels pour la prolifération et la migration cellulaires in vitro et in vivo en trois dimensions (3D). Des hydrogels à base de polyamidoamines avec d'intéressantes propriétés physicochimiques et une remarquable biocompatibilité ont été développés pour différentes applications biomédicales. Un hydrogel avec des sondes luminescentes d’iridium(III) incorporés de manière covalente, a été conçue comme plate-forme 3D de culture cellulaire, pour la visualisation directe des cellules vivantes en temps réel, et a démontré être un puissant outil de bi

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46

Schutte, Berend. "Cancer cell ploidy and proliferation in colorectal carcinoma." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1987. http://arno.unimaas.nl/show.cgi?fid=5360.

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47

Simon, Charles. "Novel resveratrol analogues : synthesis, metabolism and cell proliferation." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9289.

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Resveratrol or trans-3,4’,5-trihydroxystilbene is a naturally occurring phytochemical contained in red grapes skin, nuts and berries. It has been shown over the years to have different biological properties particularly in the chemoprevention of cancer. However, it is metabolised in vivo to sulfates and glucuronides within 1h and is active against different targets in a dose dependant manner. A library of new analogues of resveratrol has been synthesised with the aim of stopping or at least slowing down the metabolism whilst keeping its activity on the inhibition of cancer cell proliferation.

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48

Penglong, Tipparat. "Molecular Basis of Erythroid Cell Proliferation and Differentiation." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T022.

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Pour assurer la production de milliards de globules rouges, l’érythropoièse doit parfaitement contrôler les processus de prolifération et de différenciation. Ces deux processus sont régulés par l’expression de gènes spécifiques dépendant d’une coordination entre l’activité des facteurs de transcription (FT) et les fonctions épigénétiques portées par exemple par les protéines à bromodomaine. Cette étude se concentre sur les conséquences de l’association ou la dissociation du FT clef de l’érythropoièse GATA-1 avec les FT déterminant pour le cycle cellulaire, pRb et E2F. Dans la première partie d

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49

Gui, Dan Y. (Dan Yi). "The role of respiration in supporting cell proliferation." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/115451.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, June 2017.<br>Cataloged from PDF version of thesis. "May 2017." Page 163 blank. Vita.<br>Includes bibliographical references.<br>Compared to non-proliferating cells, proliferating cells such as cancer cells have additional metabolic requirements for generating biomass. However, despite these additional requirements the components of the mammalian metabolic network in both proliferating and non-proliferating cells are largely the same. Thus, in order to balance the competing anabolic and catabolic needs of a prolifera

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Stöber, Kai. "Pre-replicative complex proteins and human cell proliferation." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621319.

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