Relevant bibliographies by topics / Cell niche

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cell niche'

Author: Grafiati
Published: 24 April 2022

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Journal articles on the topic "Cell niche"

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Ema, Hideo, and Toshio Suda. "Two anatomically distinct niches regulate stem cell activity." Blood 120, no. 11 (September 13, 2012): 2174–81. http://dx.doi.org/10.1182/blood-2012-04-424507.

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Abstract The niche microenvironment controls stem cell number, fate, and behavior. The bone marrow, intestine, and skin are organs with highly regenerative potential, and all produce a large number of mature cells daily. Here, focusing on adult stem cells in these organs, we compare the structures and cellular components of their niches and the factors they produce. We then define the niche as a functional unit for stem cell regulation. For example, the niche possibly maintains quiescence and regulates fate in stem cells. Moreover, we discuss our hypothesis that many stem cell types are regulated by both specialized and nonspecialized niches, although hematopoietic stem cells, as an exception, are regulated by a nonspecialized niche only. The specialized niche is composed of 1 or a few types of cells lying on the basement membrane in the epithelium. The nonspecialized niche is composed of various types of cells widely distributed in mesenchymal tissues. We propose that the specialized niche plays a role in local regulation of stem cells, whereas the nonspecialized niche plays a role in relatively broad regional or systemic regulation. Further work will verify this dual-niche model to understand mechanisms underlying stem cell regulation.
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Hayashi, Yoshiki, Satoru Kobayashi, and Hiroshi Nakato. "Drosophila glypicans regulate the germline stem cell niche." Journal of Cell Biology 187, no. 4 (November 9, 2009): 473–80. http://dx.doi.org/10.1083/jcb.200904118.

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Stem cells are maintained in vivo by short-range signaling systems in specialized microenvironments called niches, but the molecular mechanisms controlling the physical space of the stem cell niche are poorly understood. In this study, we report that heparan sulfate (HS) proteoglycans (HSPGs) are essential regulators of the germline stem cell (GSC) niches in the Drosophila melanogaster gonads. GSCs were lost in both male and female gonads of mutants deficient for HS biosynthesis. dally, a Drosophila glypican, is expressed in the female GSC niche cells and is responsible for maintaining the GSC niche. Ectopic expression of dally in the ovary expanded the niche area, showing that dally is required for restriction of the GSC niche space. Interestingly, the other glypican, dally-like, plays a major role in regulating male GSC niche maintenance. We propose that HSPGs define the physical space of the niche by serving as trans coreceptors, mediating short-range signaling by secreted factors.
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Chan, Charles, Ching-Cheng Chen, Daniel L. Kraft, Cynthia Luppen, Jae-Beom Kim, Anthony DeBoer, Kevin Wei Wei, and Irving L. Weissman. "Identification and Isolation of the Hematopoietic Stem Cell Niche Initiating Cell Population." Blood 112, no. 11 (November 16, 2008): 3574. http://dx.doi.org/10.1182/blood.v112.11.3574.3574.

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Abstract Introduction: Identification and understanding of the cells and processes that can generate, sustain and influence the HSC niche and hematopoiesis are critical for the development of a more comprehensive knowledge of normal hematopoiesis, stem cell homing, trafficking, differentiation and hematopoietic pathology. Growth and renewal in many tissues are initiated by stem cells, supported by the microenvironment (niche) in which they reside. While recent work has begun to describe functional interactions between stem cells and their niches, little is known about the formation of stem cell niches. Methods & Results: We established a functional, in vivo assay (via implantation of cells under the renal capsule) to isolate the determinants of hematopoietic stem cell (HSC) niche formation and activity. Using this novel assay, we show that a population of progenitor cells (CD45−Tie2-aV+CD105+Thy1.1−; CD105+Thy1−) sorted from 15.5 dpc fetal limbs and transplanted under the adult mouse renal capsule recruit host-derived vasculatures in a VEGF dependent manner, produce donor-derived ectopic bones through endochondral ossification, and generate a marrow cavity populated by host-derived long term reconstituting HSC (LT-HSC). In contrast, CD45−Tie2-aV+CD105+Thy1a+ (CD105+Thy1+) progenitors form bone that does not contain a marrow cavity. While analyzing these and other sorted populations, we did not observe any instances where niche was present without bone, suggesting that skeletal progenitors are necessary for initiating an HSC niche but osteoblasts alone cannot initiate and support niche activity. Suppression of factors important for HSC maintenance, such as steel factor (SLF), in progenitor populations prior to transplant did not alter their ability to initiate and support an HSC niche. On the other hand, suppression of factors involved in endochondral ossification, such as osterix and VEGF, inhibited niche generation. Furthermore, CD105+Thy1− progenitor populations derived from regions of the fetal mandible or calvaria that do not undergo endochondral ossification form only bone without marrow in our assay. Conclusions: In addition to identifying the limb-derived skeletal progenitor capable of endochondral ossification involved and the basic mechanisms of HSC niche initiation, our study provides a functional framework by which future studies on HSC-niche interactions at the cellular level can be carried out.
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Gulmez Sevim, Duygu, and Ugur Acar. "Stem Cell-Based Treatment Modalities for Limbal Stem Cell Deficiency." Niche Journal 2, no. 3 (February 9, 2015): 25–30. http://dx.doi.org/10.5152/niche.2014.166.

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Cakmak, Hasan Basri. "Corneal Endothelial Cell Sheaths: A New Avenue in Stem Cell Research?" Niche Journal 2, no. 3 (February 9, 2015): 31–35. http://dx.doi.org/10.5152/niche.2014.169.

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Sharma, Shilpa, and Gurudutta Gangenahalli. "Adult Hematopoietic Stem Cells: Niche Cross-Talks to Affect the Cell Fate." Niche Journal 3, no. 1 (January 6, 2016): 12–23. http://dx.doi.org/10.5152/niche.2015.215.

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Ozdemir, Aysun, and Mustafa Ark. "xCELLigence Real Time Cell Analysis System: A New Method for Cell Proliferation and Cytotoxicity." Niche Journal 2, no. 2 (September 12, 2014): 15–17. http://dx.doi.org/10.5152/niche.2014.153.

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Kandarakov, Oleg, Alexander Belyavsky, and Ekaterina Semenova. "Bone Marrow Niches of Hematopoietic Stem and Progenitor Cells." International Journal of Molecular Sciences 23, no. 8 (April 18, 2022): 4462. http://dx.doi.org/10.3390/ijms23084462.

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The mammalian hematopoietic system is remarkably efficient in meeting an organism’s vital needs, yet is highly sensitive and exquisitely regulated. Much of the organismal control over hematopoiesis comes from the regulation of hematopoietic stem cells (HSCs) by specific microenvironments called niches in bone marrow (BM), where HSCs reside. The experimental studies of the last two decades using the most sophisticated and advanced techniques have provided important data on the identity of the niche cells controlling HSCs functions and some mechanisms underlying niche-HSC interactions. In this review we discuss various aspects of organization and functioning of the HSC cell niche in bone marrow. In particular, we review the anatomy of BM niches, various cell types composing the niche, niches for more differentiated cells, metabolism of HSCs in relation to the niche, niche aging, leukemic transformation of the niche, and the current state of HSC niche modeling in vitro.
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Boulais, Philip E., and Paul S. Frenette. "Making sense of hematopoietic stem cell niches." Blood 125, no. 17 (April 23, 2015): 2621–29. http://dx.doi.org/10.1182/blood-2014-09-570192.

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Abstract The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and proliferation. Anatomic localization of the niche is a dynamic unit from the developmental stage that allows proliferating HSCs to expand before they reach the bone marrow where they adopt a quiescent phenotype that protects their integrity and functions. Recent studies have sought to clarify the complexity behind the HSC niche by assessing the contributions of specific cell populations to HSC maintenance. In particular, perivascular microenvironments in the bone marrow confer distinct vascular niches that regulate HSC quiescence and the supply of lineage-committed progenitors. Here, we review recent data on the cellular constituents and molecular mechanisms involved in the communication between HSCs and putative niches.
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Khlusov, Igor A., Larisa S. Litvinova, Marina Yu Khlusova, and Kristina A. Yurova. "Concept of Hematopoietic and Stromal Niches for Cell-Based Diagnostics and Regenerative Medicine (a Review)." Current Pharmaceutical Design 24, no. 26 (November 14, 2018): 3034–54. http://dx.doi.org/10.2174/1381612824666180829154119.

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Background: R. Schofield (1978) proposed a hypothesis of hematopoietic stem cells (HSCs) niche (specialized cell microenvironment). An existence of osteoblastic and vascular niches for HSCs has been postulated since 2003. At the same time, the discussion about the existence and functioning of niche for multipotent mesenchymal stromal cells (MMSCs) is just beginning to develop. The design of artificial materials capable of biomimetical reproductionof the cellular and tissue microenvironment based on ideas and main elements borrowed from wildlife is an experimental approach in search of the stem cell niches. Results: Recent attempts to model the microterritories (niches) for HSCs have been undertaken and the behavior of cells in such structures has been investigated. However, the main quantitative factors involved in the original design of stem cell microterritories remain unknown. At the modern stage, the topography, hierarchy, and the size of the niches have to be determined, because the definition of the niches as morphological (structural and functional) units (microterritories), which provides the conditions for vital activity of stem cells, implies finite values of its parameters. The aim of this review was the critical review of key milestones of the niche concept for HSCs and MMSCs as we understood it. Conclusion: We speculated our definition of the stem cell niche, proposed and described certain stages (postulation; morphofunctional; topographical; quantitative; bioengineering) of the niche theory development. Prospective directions of the niche designing for cell-based diagnostics and regenerative medicine were noted.
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Dissertations / Theses on the topic "Cell niche"

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Young, Christopher Cheng. "The adult neural stem cell niche in ischaemic stroke." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:86e6e236-047c-46d8-96e5-449a3f0505a8.

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Ischaemic stroke is a major cause of mortality and chronic disability for which there is no effective treatment. The subventricular zone (SVZ) is an adult neurogenic niche which mediates limited endogenous repair following stroke. To harness this phenomenon for therapy, it is important to understand how the SVZ niche is altered in stroke, and the processes that recruit neural precursors to the site of injury, which becomes a de facto neurogenic niche. Galectin-3 (Gal-3) is a β-galactoside binding protein involved in cellular adhesion, inflammation and tumour metastasis. Gal-3 is specifically expressed in the SVZ and maintains neuroblast migration to the olfactory bulb, although its role in post-stroke neurogenesis is not well-understood. Therefore, this project aimed to (1) characterise the cytoarchitecture of the SVZ in response to stroke, and (2) examine the role of Gal-3 in stroke outcome and tissue remodelling, and test the hypothesis that Gal-3 is required for neuroblast ectopic migration into the ischaemic striatum. Using the intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice, and whole mounts of the lateral ventricular wall, significant SVZ reactive astrocytosis and increased vascular branching were observed, thereby disrupting the neuroblast migratory scaffold. Stroke increased SVZ cell proliferation without increase in cell death. Post-stroke ependymal cells were enlarged and non-proliferative, and assumed a reactive astroglial phenotype, expressing de novo high levels of glial fibrillary acidic protein. This was associated with focal planar cell polarity misalignment, and turbulent and decreased rate of cerebrospinal fluid flow. These findings demonstrate significant changes in multiple SVZ cell types which are positioned to influence post-stroke neurogenesis and regulation of the neural stem cell niche Gal-3 was up-regulated in the ischaemic brain and ipsilateral SVZ. To elucidate the role of Gal-3 after stroke, MCAO was performed in wildtype and Gal-3 null (Gal-3-/-) mice, and parameters of stroke outcome and post-stroke neurogenesis compared. The deletion of Gal-3 did not affect infarct volumes or neurological outcomes, although neuroblast migration into the ischaemic striatum was increased in Gal-3-/- brains. Gal-3-/- mice failed to mount an angiogenic response in the ischaemic striatum, and this was associated with lower levels of vascular endothelial growth factor (VEGF) and increased anti-angiogenic protein levels. Loss of Gal-3 further disrupted the pro-proliferative neural-vascular interaction at the basement membrane. The current data indicate that Gal-3 is a pleiotropic molecule which has distinct roles in both the SVZ and the post-stroke striatum as niches of adult neurogenesis.
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Michel, Marcus. "Stem cell regulation in the Drosophila testicular niche." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-121226.

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All multicellular organisms constantly need to replace aged or damaged cells. This vital task of tissue homeostasis is fulfilled by stem cells. The balance between self-renewal and differentiation of the stem cell is crucial for this task and tightly regulated by a signaling microenvironment termed the niche. A widely used model for studying stem cell niche biology is the Drosophila testis, where two stem cell populations, the germline stem cells (GSCs) and the somatic cyst stem cells (CySCs), reside in a niche located at the apical tip. A lot is known about the signals regulating GSC maintenance in the testicular niche. It is, however, unknown how the spatial regulation of these signals defines the range of the niche. Here I show, that Bone Morphogenetic Protein (BMP) signaling is specifically activated at the interface of niche and stem cells. This local activation is achieved by coupling the transport of adhesion and signaling molecules in the niche cells and directing their transport to contact sites of niche and stem cells. Localized niche signaling at junctions underlies the so called stem-cell-niche synapse hypothesis proposed for the mammalian hematopoietic stem cell niche. I have shown that disrupting the localized transport causes premature differentiation and stem cell loss. BMP signaling between niche and GSCs therefore provides the first description of a stem-cell-niche synapse and will yield valuable insights into mammalian stem cell biology. The CySCs reside in the niche of the testis together with the GSCs. To understand how the niche maintains both stem cell types in a concerted way, it is essential to know the pathways regulating both stem cell types. Here I show that Hedgehog (Hh) signaling is a key stem cell factor of CySCs, while only indirectly affecting GSCs. Loss of Hh signaling in CySCs results in premature differentiation and consequent loss of the cells. Overactivation of the pathway leads to an increased proliferation and an expansion of the cyst stem cell compartment. As Hh signaling is also a regulator of the somatic cells in the mammalian testis and the Drosophila ovary this may reflect a higher degree of homology between these systems than previously expected.
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Yeung, Aaron Ming Hon. "Limbal stem cell niche and ocular surface reconstruction." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580161.

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In the quest to master ocular surface regeneration, one must isolate the stem cells at the limbus and understand them. The stem cell niche is a concept that-was first described in 1978 and subsequently gained interest and became widely accepted. The work presented in Chapter 2 sought to characterize the stem cell niche at the ocular surface, and in doing so led to further understanding of stem cells at the limbus. In Chapter 3 the sampling of infant tissue provided further insight into the niche at that age group. In Chapter 4, Desmoglein 3 was hypothesized to be a negative stem cell marker. Finally in Chapter 5, the Amniotic Membrane was investigated as a possible surrogate stem cell niche. The stem cells at the limbus have not been isolated yet, but hopefully we are one step closer to mastering ocular surface reconstruction.
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Paton-Hough, Julia. "Defining key molecules in a myeloma cell niche." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6732/.

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Multiple myeloma is an incurable B cell malignancy characterised by the expansion of malignant plasma cells in the bone marrow. It has been suggested that during initial colonisation of bone and possibly during therapy, some myeloma cells may occupy a bone marrow niche similar to that inhabited by haemopoietic stem cells. Haemopoietic stem cells residing in BM niches adhere to osteoblastic cells via a series of molecules that promote haemopoietic stem cell quiescence. Therefore, we hypothesise that myeloma cells express the same molecules as haemopoietic stem cells, chemokine C-X-C-motif-receptor 4, notch-1, tyrosine kinase-2 and n-cadherin, which interact with their complementary ligands expressed by osteoblastic cells, chemokine C-X-C-motif-ligand 12, jagged-1, angiopoietin-1 and n-cadherin. These interactions may result in myeloma cell adhesion to an osteoblastic niche, resulting in myeloma cell dormancy. The aims of these studies were to determine the expression of haemopoietic stem cell niche molecules and ligands by murine myeloma cell lines and osteoblastic cells and to determine the role of one of the key molecules in vitro and in vivo. 5T33MMvt and 5TGM1 cells expressed the haemopoietic stem cell niche molecules; chemokine C-X-C-motif-receptor 4, notch-1, tyrosine kinase-2 and n-cadherin and the MC3T3-E1 cells and primary osteoblast lineage cells expressed the ligands chemokine C-X-C-ligand 12, jagged-1, angiopoietin-1 and n-cadherin. Knock-down of n-cadherin was achieved in the 5TGM1 cells, with 71% gene and 75% protein reduction. 5TGM1 n-cadherin knock-down cell attachment to primary osteoblast lineage cells was reduced in vitro, though this did not reach significance. Mice injected with 5TGM1 n-cadherin knock-down cells had significantly less tumour in vivo compared to controls. In conclusion, murine myeloma cells expressed the same repertoire of molecules as haemopoietic stem cells and osteoblastic cells expressed their complementary ligands. Knock-down of one of these key molecules, n-cadherin, did not significantly inhibit myeloma cell attachment to primary osteoblasts in vitro but potentially impaired tumour growth in vivo. Further experiments are required to confirm this.
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Joshi, Ramila Joshi. "Micro-engineering of embryonic stem cells niche to regulate neural cell differentiation." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1544029342969082.

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Gu, Ying. "A Traveling Niche: The Role of Steel Factor in Mouse Primordial Germ Cell Development." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321370449.

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Zhao, Yiding. "Characterization of the developing haematopoietic stem cell niche using a novel immortalization system." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22025.

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Embryonic haematopoiesis is a complex process under intensive research. Murine definitive Haematopoietic Stem Cells (HSCs) originates from the Aorta-Gonad-Mesonephros (AGM) region of E10.5 embryo. It is thought that definitive HSCs arise from endothelial lining of dorsal aorta. However, detail of HSC specification in the developing embryo remains elusive. One way to deciphering events occurred during HSC specification is to derive cell lines from the developing HSC niche. Previous work by Oostendorp et al. showed the AGM and fetal liver derived lines could maintain HSCs in vitro (Oostendorp, Harvey et al. 2002). In this study, I established a more robust immortalization system using normal SV40 large T antigen delivered via Neon™ electroporation system. The new immortalization system achieved direct immortalization without going through crisis. And it is compatible with small number of primary cells dissected from different haematopoietic niches. With my new system, multiple cell lines from different haematopoietic sites at different developmental points are derived. Moreover, some of these lines demonstrated ability to mature precursors from E9.5 embryo (pro-HSCs) to definitive HSC without help of growth factors. This result is better compared to OP9 stromal lines. Such data proved usefulness of using stromal cell lines to study haematopoietic specification.
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Mirzadeh, Zaman. "Epithelial organization of the adult neural stem cell niche." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311332.

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Thesis (Ph.D.)--University of California, San Francisco, 2008.
Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3358. Adviser: Arturo Alvarez-Buylla. Includes supplementary digital materials.
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Young, Sarah Jane. "Biomechanical modelling of the gastrointestinal epithelial stem cell niche." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518236.

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Wang, Longlong. "A mesenchymal stem cell (MSC) niche in mouse incisor." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/a-mesenchymal-stem-cell-msc-niche-in-mouse-incisor(8f92b75d-f90f-4c58-ab06-682af9f90e95).html.

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Mesenchymal stem cells (MSCs) are heterogeneous cell populations that are identified by their in vitro characteristics while their biological properties and in vivo identities are often less understood. Different from human teeth, mouse incisors grow and erupt continuously throughout their lives and compensate for daily abrasions with the existence of stem cells. However, the precise location of the mesenchymal stem cells (MSCs) in the incisor is unclear. Generally, the MSCs in the mouse incisor are believed to be located in the mesenchyme close to the epithelium cervical loops, since the growth and differentiation of the incisor always initiates at the apical end and extends towards the incisal end. The utilization of label-retaining experiments and transgenic reporter mouse lines has enabled further understanding of the less established identities and properties of dental pulp stem cells in vivo. The work described in this thesis demonstrates that the mesenchymal stem cell niche located at the apical end of mouse incisor contains three distinct but connected cell populations: 1) a slow cycling cell population containing Thy-1+ cells essential for tooth dental pulp and odontoblast formation 2) a Ring1/Bcor-associated fast cycling cell population crucial for maintaining tissue growth and homeostasis of epithelium stem cells in labial cervical loop 3) a quiescent long-term cell population marked by Flamingo homologue Celsr1 might respond to generate new stem cells when the stem cells become depleted.
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Books on the topic "Cell niche"

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Turksen, Kursad, ed. Stem Cell Niche. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9508-0.

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Turksen, Kursad, ed. Stem Cell Niche. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8.

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Roy, Krishnendu, ed. Biomaterials as Stem Cell Niche. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13893-5.

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Turksen, Kursad, ed. Biology in Stem Cell Niche. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21702-4.

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Turksen, Kursad, ed. Tissue-Specific Stem Cell Niche. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21705-5.

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Schaible, Ulrich E., and Haas Albert. Intracellular niches of microbes: A pathogens guide through the host cell. Weinheim: Wiley-VCH, 2009.

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Rice, Jerry M. The bone marrow niche, stem cells, and leukemia: Impact of drugs, chemicals, and the environment. Hoboken, NJ: published on behalf of the New York Academy of Sciences by Wiley Subscription Services, Inc., 2014.

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Sugao no Yamanaka Shin'ya: Kisha ga otta 2500-nichi. Kyōto-shi: Nakanishiya Shuppan, 2013.

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E.C. Photovoltaic Solar Energy Conference (13th 1995 Nice, France). Thirteenth European Photovoltaic Solar Energy Conference: Proceedings of the International Conference, held at Nice, France, 23-27 October 1995. Bedford, UK: H.S. Stephens & Associates, 1995.

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Kagaku Gijutsu no Mirai o Tenbōsuru Senryaku Wākushoppu (2004 Tokyo, Japan). Kagaku Gijutsu no Mirai o Tenbōsuru Wākushoppu: Suiso enerugī shisutemu no kanōsei to kadai (Heisei 16-nen 4-gatsu 10-nichi--11nichi kaisai) : hōkokusho. Tōkyō: Kagaku Gijutsu Shinkō Kikō Kenkyū Kaihatsu Senryaku Sentā Inoue Jōseki Ferō Gurūpu, 2004.

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Book chapters on the topic "Cell niche"

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Dalloul, Ali. "Hypoxia and Visualization of the Stem Cell Niche." In Stem Cell Niche, 199–205. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_17.

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McCauley, Heather A., and Géraldine Guasch. "Serial Orthotopic Transplantation of Epithelial Tumors in Single-Cell Suspension." In Stem Cell Niche, 231–45. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_20.

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Luo, Lichao, Phing Chian Chai, and Yu Cai. "Immunostaining of Germline Stem Cells and the Niche in Drosophila Ovaries." In Stem Cell Niche, 1–7. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_1.

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Heazlewood, Shen Y., Brenda Williams, Melonie J. Storan, and Susan K. Nilsson. "The Prospective Isolation of Viable, High Ploidy Megakaryocytes from Adult Murine Bone Marrow by Fluorescence Activated Cell Sorting." In Stem Cell Niche, 121–33. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_10.

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Gaviro, María Victoria Gómez, Pedro Luis Sánchez Fernández, Robin Lovell Badge, and Francisco Fernández Avilés. "Looking for the Niche: Substance Delivery into the Lateral Ventricle of the Brain: The Osmotic Minipump System." In Stem Cell Niche, 135–40. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_11.

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Falcão, Ana Mendanha, Joana Almeida Palha, Ana Catarina Ferreira, Fernanda Marques, Nuno Sousa, and João Carlos Sousa. "Unbiased Stereological Method to Assess Proliferation Throughout the Subependymal Zone." In Stem Cell Niche, 141–52. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_12.

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Mishra, Paras Kumar, Nicholas John Kuypers, Shree Ram Singh, Noel Diaz Leiberh, Vishalakshi Chavali, and Suresh C. Tyagi. "Cardiac Stem Cell Niche, MMP9, and Culture and Differentiation of Embryonic Stem Cells." In Stem Cell Niche, 153–63. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_13.

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Abou-Khalil, Rana, Fabien Le Grand, and Bénédicte Chazaud. "Human and Murine Skeletal Muscle Reserve Cells." In Stem Cell Niche, 165–77. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_14.

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Boldrin, Luisa, and Jennifer E. Morgan. "Modulation of the Host Skeletal Muscle Niche for Donor Satellite Cell Grafting." In Stem Cell Niche, 179–90. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_15.

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Pozzobon, Michela, Martina Piccoli, Andrea Alex Schiavo, Anthony Atala, and Paolo De Coppi. "Isolation of c-Kit+ Human Amniotic Fluid Stem Cells from Second Trimester." In Stem Cell Niche, 191–98. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-508-8_16.

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Conference papers on the topic "Cell niche"

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Simion, Luminita, Georgina Shaw, Florin Zugun Eloae, Paul Botez, Marry Murphy, and Frank Barry. "Stem Cell Niche in Osteoarthritic Joints - Preliminary Results." In 2010 Advanced Technologies for Enhancing Quality of Life (ATEQUAL). IEEE, 2010. http://dx.doi.org/10.1109/atequal.2010.9.

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Giles, Amber J., Meera Murgai, Yorleny Vicioso, Steven Highfil, Crystal Mackall, Leonard Wexler, David Lyden, and Rosandra Natasha Kaplan. "Abstract 3058: Bone marrow hematopoietic stem cell niche activation and mobilization fosters the metastatic niche." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3058.

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Croucher, Peter, Weng Hua Khoo, Ryan Chai, Alex Corr, James Smith, Qihao Ren, Paul Baldock, Michelle McDonald, Sheila Stewart, and Tri G. Phan. "Abstract IA015: Niche-dependent control of tumor cell dormancy." In Abstracts: AACR Virtual Special Conference: The Evolving Tumor Microenvironment in Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities; in association with the Tumor Microenvironment (TME) Working Group; January 11-12, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.tme21-ia015.

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Van Hamme, Evelien. "The liver revisited: CLEM reveals the Kupffer cell niche." In European Microscopy Congress 2020. Royal Microscopical Society, 2021. http://dx.doi.org/10.22443/rms.emc2020.602.

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Zon, Leonard I. "Abstract SY42-02: Stem cell clonality and the niche." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-sy42-02.

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Liu, Qingxin, Kristina Shahriari, Marina Sazanovich, Danielle Jernigan, and Alessandro Fatatis. "Abstract 3943: Cancer cell cooperation in the bone metastatic niche." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3943.

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Clement, Amanda L., and George D. Pins. "Every cell has its niche: Harnessing microtopography to control keratinocyte fate." In 2014 40th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2014. http://dx.doi.org/10.1109/nebec.2014.6972759.

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Zhu, Thant S., Shawn Hervey-Jumper, Francesco DiMeco, Angelo L. Vescovi, Jason A. Heth, Karin M. Muraszko, and Xing Fan. "Abstract 4235: Notch ligand-dependent cancer stem cell niche in glioblastoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4235.

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Coppes, Rob P. "Abstract IA-020: Optimizing stem cell niche for post-irradiation regeneration." In Abstracts: AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1557-3265.radsci21-ia-020.

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Wieland, J., T. Agibalova, AM Bührer, IE Demir, B. Kohnke-Ertel, M. Quante, RM Schmid, and M. Middelhoff. "Characterization of the cholinergic stem cell niche in the murine colon." In Viszeralmedizin 2021 Gemeinsame Jahrestagung Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), Sektion Endoskopie der DGVS, Deutsche Gesellschaft für Allgemein und Viszeralchirurgie (DGAV). Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1733541.

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Reports on the topic "Cell niche"

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Hinch, Lindsay. Elucidating the Tumor Suppressive Role of SLITs in Maintaining the Basal Cell Niche. Fort Belvoir, VA: Defense Technical Information Center, July 2010. http://dx.doi.org/10.21236/ada537890.

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Hinck, Lindsay. Elucidating the Tumor-Suppressive Role of SLITs in Maintaining the Basal Cell Niche. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada561080.

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Hinck, Lindsay. Elucidating the Tumor Suppressive Role of SLITs in Maintaining the Basal Cell Niche. Fort Belvoir, VA: Defense Technical Information Center, July 2009. http://dx.doi.org/10.21236/ada515794.

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Chepko, Gloria, and Leena Hilakivi-Clarke. Role of the Stem Cell Niche in Hormone-induced Tumorigenesis in Fetal Mouse Mammary Epithelium. Fort Belvoir, VA: Defense Technical Information Center, August 2006. http://dx.doi.org/10.21236/ada471087.

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Dijkema, G. P. J., J. Grievink, C. P. Luteijn, and M. P. C. Weijnen. The chemical industry, a novel market NICHE for fuel cells? Office of Scientific and Technical Information (OSTI), December 1996. http://dx.doi.org/10.2172/460272.

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Marsden, Carolyn. Mesenchymal Stem Cells in the Bone Marrow Provide a Supportive Niche for Early Disseminated Breast Tumor-Initiating Cells. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada552881.

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Shpigel, Nahum Y., Ynte Schukken, and Ilan Rosenshine. Identification of genes involved in virulence of Escherichia coli mastitis by signature tagged mutagenesis. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7699853.bard.

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Mastitis, an inflammatory response of the mammary tissue to invading pathogenic bacteria, is the largest health problem in the dairy industry and is responsible for multibillion dollar economic losses. E. coli are a leading cause of acute mastitis in dairy animals worldwide and certainly in Israel and North America. The species E. coli comprises a highly heterogeneous group of pathogens, some of which are commensal residents of the gut, infecting the mammary gland after contamination of the teat skin from the environment. As compared to other gut microflora, mammary pathogenic E. coli (MPEC) may have undergone evolutionary adaptations that improve their fitness for colonization of the unique and varied environmental niches found within the mammary gland. These niches include competing microbes already present or accompanying the new colonizer, soluble and cellular antimicrobials in milk, and the innate immune response elicited by mammary cells and recruited immune cells. However, to date, no specific virulence factors have been identified in E. coli isolates associated with mastitis. The original overall research objective of this application was to develop a genome-wide, transposon-tagged mutant collection of MPEC strain P4 and to use this technology to identify E. coli genes that are specifically involved in mammary virulence and pathogenicity. In the course of the project we decided to take an alternative genome-wide approach and to use whole genomes bioinformatics analysis. Using genome sequencing and analysis of six MPEC strains, our studies have shown that type VI secretion system (T6SS) gene clusters were present in all these strains. Furthermore, using unbiased screening of MPEC strains for reduced colonization, fitness and virulence in the murine mastitis model, we have identified in MPEC P4-NR a new pathogenicity island (PAI-1) encoding the core components of T6SS and its hallmark effectors Hcp, VgrG and Rhs. Next, we have shown that specific deletions of T6SS genes reduced colonization, fitness and virulence in lactating mouse mammary glands. Our long-term goal is to understand the molecular mechanisms of host-pathogen interactions in the mammary gland and to relate these mechanisms to disease processes and pathogenesis. We have been able to achieve our research objectives to identify E. coli genes that are specifically involved in mammary virulence and pathogenicity. The project elucidated a new basic concept in host pathogen interaction of MPEC, which for the best of our knowledge was never described or investigated before. This research will help us to shed new light on principles behind the infection strategy of MPEC. The new targets now enable prevalence and epidemiology studies of T6SS in field strains of MPEC which might unveil new geographic, management and ecological risk factors. These will contribute to development of new approaches to treat and prevent mastitis by MPEC and perhaps other mammary pathogens. The use of antibiotics in farm animals and specifically to treat mastitis is gradually precluded and thus new treatment and prevention strategies are needed. Effective mastitis vaccines are currently not available, structural components and effectors of T6SS might be new targets for the development of novel vaccines and therapeutics.
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Or, Dani, Shmulik Friedman, and Jeanette Norton. Physical processes affecting microbial habitats and activity in unsaturated agricultural soils. United States Department of Agriculture, October 2002. http://dx.doi.org/10.32747/2002.7587239.bard.

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experimental methods for quantifying effects of water content and other dynamic environmental factors on bacterial growth in partially-saturated soils. Towards this end we reviewed critically the relevant scientific literature and performed theoretical and experimental studies of bacterial growth and activity in modeled, idealized and real unsaturated soils. The natural wetting-drying cycles common to agricultural soils affect water content and liquid organization resulting in fragmentation of aquatic habitats and limit hydraulic connections. Consequently, substrate diffusion pathways to soil microbial communities become limiting and reduce nutrient fluxes, microbial growth, and mobility. Key elements that govern the extent and manifestation of such ubiquitous interactions include characteristics of diffusion pathways and pore space, the timing, duration, and extent of environmental perturbations, the nature of microbiological adjustments (short-term and longterm), and spatial distribution and properties of EPS clusters (microcolonies). Of these key elements we have chosen to focus on a manageable subset namely on modeling microbial growth and coexistence on simple rough surfaces, and experiments on bacterial growth in variably saturated sand samples and columns. Our extensive review paper providing a definitive “snap-shot” of present scientific understanding of microbial behavior in unsaturated soils revealed a lack of modeling tools that are essential for enhanced predictability of microbial processes in soils. We therefore embarked on two pronged approach of development of simple microbial growth models based on diffusion-reaction principles to incorporate key controls for microbial activity in soils such as diffusion coefficients and temporal variations in soil water content (and related substrate diffusion rates), and development of new methodologies in support of experiments on microbial growth in simple and observable porous media under controlled water status conditions. Experimental efforts led to a series of microbial growth experiments in granular media under variable saturation and ambient conditions, and introduction of atomic force microscopy (AFM) and confocal scanning laser microscopy (CSLM) to study cell size, morphology and multi-cell arrangement at a high resolution from growth experiments in various porous media. The modeling efforts elucidated important links between unsaturated conditions and microbial coexistence which is believed to support the unparallel diversity found in soils. We examined the role of spatial and temporal variation in hydration conditions (such as exist in agricultural soils) on local growth rates and on interactions between two competing microbial species. Interestingly, the complexity of soil spaces and aquatic niches are necessary for supporting a rich microbial diversity and the wide array of microbial functions in unsaturated soils. This project supported collaboration between soil physicists and soil microbiologist that is absolutely essential for making progress in both disciplines. It provided a few basic tools (models, parameterization) for guiding future experiments and for gathering key information necessary for prediction of biological processes in agricultural soils. The project sparked a series of ongoing studies (at DTU and EPFL and in the ARO) into effects of soil hydration dynamics on microbial survival strategy under short term and prolonged desiccation (important for general scientific and agricultural applications).
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Kapulnik, Yoram, and Donald A. Phillips. Isoflavonoid Regulation of Root Bacteria. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7570561.bard.

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The overall objective of this project was to develop a conceptual framework for enhancing root colonization by beneficial bacteria. To accomplish this aim we tested the hypothesis that production and excretion of the plant phytoalexin medicarpin can be used for creation of a special niche along the legume roots, where beneficial microorganism, such as rhizobium, will have a selective advantage. On the Israeli side it was shown that higher medicarpin levels are exuded following the application of Rhizobium meliloti to the rhizosphere but the specific biochemical pathway governing medicarpin production was not induced significantly enough to support a constant production and excretion of this molecule to the rhizosphere. Furthermore, pathogenic bacteria and chemical elicitors were found to induce higher levels of this phytoalexin and it became important to test its natural abundance in field grown plants. On the US side, the occurrence of flavonoids and nucleosides in agricultural soils has been evaluated and biologically significant quantities of these molecules were identified. A more virulent Agrobacterium tumefaciens strain was isolated from alfalfa (Medicago sativa L.) which forms tumors on a wide range of plant species. This isolate contains genes that increase competitive colonization abilities on roots by reducing the accumulation of alfalfa isoflavonoids in the bacterial cells. Following gene tagging efforts the US lab found that mutation in the bacterial efflux pump operons of this isolate reduced its competitive abilities. This results support our original hypothesis that detoxification activity of isoflavenoids molecules, based on bacterial gene(s), is an important selection mechanism in the rhizosphere. In addition, we focused on biotin as a regulatory element in the rhizosphere to support growth of some rhizosphere microorganisms and designed a bacterial gene construct carrying the biotin-binding protein, streptavidin. Expressing this gene in tobacco roots did not affect the biotin level but its expression in alfalfa was lethal. In conclusion, the collaborative combination of basic and applied approaches toward the understanding of rhizosphere activity yielded new knowledge related to the colonization of roots by beneficial microorganisms in the presence of biological active molecules exuded from the plant roots.
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Splitter, Gary, and Menachem Banai. Microarray Analysis of Brucella melitensis Pathogenesis. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7709884.bard.

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Original Objectives 1. To determine the Brucella genes that lead to chronic macrophage infection. 2. To identify Brucella genes that contribute to infection. 3. To confirm the importance of Brucella genes in macrophages and placental cells by mutational analysis. Background Brucella spp. is a Gram-negative facultative intracellular bacterium that infects ruminants causing abortion or birth of severely debilitated animals. Brucellosis continues in Israel, caused by B. melitensis despite an intensive eradication campaign. Problems with the Rev1 vaccine emphasize the need for a greater understanding of Brucella pathogenesis that could improve vaccine designs. Virulent Brucella has developed a successful strategy for survival in its host and transmission to other hosts. To invade the host, virulent Brucella establishes an intracellular niche within macrophages avoiding macrophage killing, ensuring its long-term survival. Then, to exit the host, Brucella uses placenta where it replicates to high numbers resulting in abortion. Also, Brucella traffics to the mammary gland where it is secreted in milk. Missing from our understanding of brucellosis is the surprisingly lillie basic information detailing the mechanisms that permit bacterial persistence in infected macrophages (chronic infection) and dissemination to other animals from infected placental cells and milk (acute infection). Microarray analysis is a powerful approach to determine global gene expression in bacteria. The close genomic similarities of Brucella species and our recent comparative genomic studies of Brucella species using our B. melitensis microarray, suqqests that the data obtained from studying B. melitensis 16M would enable understanding the pathogenicity of other Brucella organisms, particularly the diverse B. melitensis variants that confound Brucella eradication in Israel. Conclusions Results from our BARD studies have identified previously unknown mechanisms of Brucella melitensis pathogenesis- i.e., response to blue light, quorum sensing, second messenger signaling by cyclic di-GMP, the importance of genomic island 2 for lipopolysaccharide in the outer bacterial membrane, and the role of a TIR domain containing protein that mimics a host intracellular signaling molecule. Each one of these pathogenic mechanisms offers major steps in our understanding of Brucella pathogenesis. Strikingly, our molecular results have correlated well to the pathognomonic profile of the disease. We have shown that infected cattle do not elicit antibodies to the organisms at the onset of infection, in correlation to the stealth pathogenesis shown by a molecular approach. Moreover, our field studies have shown that Brucella exploit this time frame to transmit in nature by synchronizing their life cycle to the gestation cycle of their host succumbing to abortion in the last trimester of pregnancy that spreads massive numbers of organisms in the environment. Knowing the bacterial mechanisms that contribute to the virulence of Brucella in its host has initiated the agricultural opportunities for developing new vaccines and diagnostic assays as well as improving control and eradication campaigns based on herd management and linking diagnosis to the pregnancy status of the animals. Scientific and Agricultural Implications Our BARD funded studies have revealed important Brucella virulence mechanisms of pathogenesis. Our publication in Science has identified a highly novel concept where Brucella utilizes blue light to increase its virulence similar to some plant bacterial pathogens. Further, our studies have revealed bacterial second messengers that regulate virulence, quorum sensing mechanisms permitting bacteria to evaluate their environment, and a genomic island that controls synthesis of its lipopolysaccharide surface. Discussions are ongoing with a vaccine company for application of this genomic island knowledge in a Brucella vaccine by the U.S. lab. Also, our new technology of bioengineering bioluminescent Brucella has resulted in a spin-off application for diagnosis of Brucella infected animals by the Israeli lab by prioritizing bacterial diagnosis over serological diagnosis.
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