Relevant bibliographies by topics / Cell mechanobiology

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Cell mechanobiology'

Author: Grafiati
Published: 6 September 2023

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Journal articles on the topic "Cell mechanobiology"

1

Kim, Deok-Ho, and Yu Sun. "Editorial: Cell Mechanobiology." Micro & Nano Letters 6, no. 5 (2011): 289. http://dx.doi.org/10.1049/mnl.2011.9045.

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Lee, David A., Martin M. Knight, Jonathan J. Campbell, and Dan L. Bader. "Stem cell mechanobiology." Journal of Cellular Biochemistry 112, no. 1 (July 12, 2010): 1–9. http://dx.doi.org/10.1002/jcb.22758.

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Castillo, Alesha B., and Christopher R. Jacobs. "Mesenchymal Stem Cell Mechanobiology." Current Osteoporosis Reports 8, no. 2 (April 13, 2010): 98–104. http://dx.doi.org/10.1007/s11914-010-0015-2.

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David Merryman, W., and Adam J. Engler. "Innovations in Cell Mechanobiology." Journal of Biomechanics 43, no. 1 (January 2010): 1. http://dx.doi.org/10.1016/j.jbiomech.2009.09.001.

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Paluch, Ewa K., and Dennis E. Discher. "Cell motion and mechanobiology." Molecular Biology of the Cell 26, no. 6 (March 15, 2015): 1011. http://dx.doi.org/10.1091/mbc.e14-12-1590.

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Kim, Deok-Ho, Pak Kin Wong, Jungyul Park, Andre Levchenko, and Yu Sun. "Microengineered Platforms for Cell Mechanobiology." Annual Review of Biomedical Engineering 11, no. 1 (August 2009): 203–33. http://dx.doi.org/10.1146/annurev-bioeng-061008-124915.

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Xia, Shumin, and Pakorn Kanchanawong. "Nanoscale mechanobiology of cell adhesions." Seminars in Cell & Developmental Biology 71 (November 2017): 53–67. http://dx.doi.org/10.1016/j.semcdb.2017.07.029.

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Ladoux, Benoit, and René-Marc Mège. "Mechanobiology of collective cell behaviours." Nature Reviews Molecular Cell Biology 18, no. 12 (November 8, 2017): 743–57. http://dx.doi.org/10.1038/nrm.2017.98.

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Lammerding, Jan, Adam J. Engler, and Roger Kamm. "Mechanobiology of the cell nucleus." APL Bioengineering 6, no. 4 (December 1, 2022): 040401. http://dx.doi.org/10.1063/5.0135299.

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Saw, Thuan Beng, Shreyansh Jain, Benoit Ladoux, and Chwee Teck Lim. "Mechanobiology of Collective Cell Migration." Cellular and Molecular Bioengineering 8, no. 1 (November 6, 2014): 3–13. http://dx.doi.org/10.1007/s12195-014-0366-3.

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Dissertations / Theses on the topic "Cell mechanobiology"

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Youngstrom, Daniel W. "Mesenchymal Stem Cell Mechanobiology and Tendon Regeneration." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64422.

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Tendon function is essential for quality of life, yet the pathogenesis and healing of tendinopathy remains poorly understood compared to other musculoskeletal disorders. The aim of regenerative medicine is to replace traditional tissue and organ transplantation by harnessing the developmental potential of stem cells to restore structure and function to damaged tissues. The recently discovered interdependency of cell phenotype and biophysical environment has created a paradigm shift in cell biology. This dissertation introduces a dynamic in vitro model for tendon function, dysfunction and development, engineered to characterize the mechanobiological relationships dictating stem cell fate decisions so that they may be therapeutically exploited for tendon healing. Cells respond to mechanical deformation via a complex set of behaviors involving force-sensitive membrane receptor activity, changes in cytoskeletal contractility and transcriptional regulation. Effective ex vivo model systems are needed to emulate the native environment of a tissue and to translate cell-matrix forces with high fidelity. A naturally-derived decellularized tendon scaffold (DTS) was invented to serve as a biomimetic tissue culture platform, preserving the structure and function of native extracellular matrix. DTS in concert with a newly designed dynamic mechanical strain system comprises a tendon bioreactor that is able to emulate the three-dimensional topography, extracellular matrix proteins, and mechanical strain that cells would experience in vivo. Mesenchymal stem cells seeded on decellularized tendon scaffolds subject to cyclic mechanical deformation developed strain-dependent alterations in phenotype and measurably improved tissue mechanical properties. The relative tenogenic efficacies of adult stem cells derived from bone marrow, adipose and tendon were then compared in this system, revealing characteristics suggesting tendon-derived mesenchymal stem cells are predisposed to differentiate toward tendon better than other cell sources in this model. The results of the described experiments have demonstrated that adult mesenchymal stem cells are responsive to mechanical stimulation and, while exhibiting heterogeneity based on donor tissue, are broadly capable of tenocytic differentiation and tissue neogenesis in response to specific ultrastructural and biomechanical cues. This knowledge of cellular mechanotransduction has direct clinical implications for how we treat, rehabilitate and engineer tendon after injury.
Ph. D.
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Gonzalez-Molina, Jordi. "Cell-biomaterial mechanical interactions : from cancer mechanobiology to cell therapies." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052561/.

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The physical characteristics of the cell microenvironment greatly affect cellular processes such as survival, proliferation, migration, and differentiation. Biomaterials with well-defined physical and chemical properties have been used to better understand the cell microenvironment. Furthermore, the physicochemical properties of biomaterials can be modulated to induce host body responses and therapeutic cell behaviour. Based on these premises, the work presented in this thesis investigated the effect of soluble polymers commonly used in cell therapies on the physical properties of the extracellular microenvironment. It was found, that viscosity-enhancing polymers induce mesenchymal migration in liver cancer cells, an effect derived from changes in integrin-dependent cell – substrate adhesion dynamics and mechanosensing. Also, the role of extracellular polymers on endothelial-derived cell alignment was explored indicating that molecular soluble polymers enhance cell elongation and alignment in a molecular weight-dependent manner. In addition, the effect of hydrogel density and crosslinking causing mechanical confinement was found to affect cancer cell growth and cell cycle progression, leading to an enhanced content in polyploid cells. Finally, the effect of mechanical confinement on liver cancer cells was taken advantage of to improve the production of biomass for a bioartificial liver device by modulating the degree of crosslinking of alginate hydrogel. In conclusion, the work presented here indicates that physical properties of both the extracellular fluid and matrix greatly affect cell behaviour and can be exploited to improve biomaterial design for in vitro testing and clinical applications.
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Smith, Rochelle. "Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31268.

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Cancer remains a problem worldwide as one of the leading causes of morbidity and mortality. Many cancer patients experience recurrence and ultimately death due to treatment failure or the development of chemoresistance. The concept of chemoresistance however is complex, recent studies have highlighted that cellular structure and extra-cellular composition, mechanics and structure play a role in the development of chemoresistance. The mechanical properties of cells impact their architecture, migration patterns, intracellular trafficking and many other cellular functions. Studies have also revealed that cellular mechanical properties are modified during cancer progression. We investigated these mechanical properties and changes to them by using a malignant melanoma cell line (WM1158) and a chemoresistant malignant melanoma cell line (SK-MEL29). Malignant melanoma was the cell line of choice as it is one of the most prominent types of cancer known to develop chemoresistance. The aim of this study was to identify the effects of chemotherapeutic drug exposure on the mechanical properties and cytoskeletal composition of drug sensitive and drug resistant malignant melanoma cells. To achieve this, a combination of Multiple particle tracking microrheology (MPTM), quantitative RT-PCR and Western blotting techniques were utilised to demonstrate changes in cytoskeletal elements that are responsible for cellular mechanics. MPTM was developed as an approach to map intracellular mechanical properties of living cells and track the intracellular particles by Brownian motion to establish a viscoelastic model and compare it with the power-law approach. A quantification of the MPTM allowed capturing of the cell stiffness using the mean squared displacement (MSD) of cell under different conditions. The cytoskeletal elements actin and β-tubulin were analysed in qRT-PCR and Western blot as they form the key elements governing a cell’s mechanical stability and response to mechanical stimuli. The findings from this study revealed cell stiffness decreases as cancer progress, thereby cells become stiffer. The same pattern was evident for chemoresistant malignant cells and revealed that they had a loss of elasticity in comparison to their counter non-resistant malignant cells. With regards to protein levels and mRNA expression, the chemotherapeutic drug affected the cytoskeleton causing cells to undergo morphological changes which, however, was not seen in chemoresistant cells. The results from this study indicated that measuring mechanical properties of cells provides an efficient marker for cancer diagnosis and deeper understanding of cancer mechanobiology.
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Wang, Ji. "Suspended Micro/Nanofiber Hierarchical Scaffolds for Studying Cell Mechanobiology." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/76884.

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Extracellular matrix (ECM) is a fibrous natural cell environment, possessing complicated micro-and nano- architectures, which provides signaling cues and influences cell behavior. Mimicking this three dimensional environment in vitro is a challenge in developmental and disease biology. Here, suspended multilayer hierarchical nanofiber assemblies fabricated using the non-electrospinning STEP (Spinneret based Tunable Engineered Parameter) fiber manufacturing technique with controlled fiber diameter (microns to less than 100 nm), orientation and spacing in single and multiple layers are demonstrated as biological scaffolds. Hierarchical nanofiber assemblies were developed to control single cell shape (shape index from 0.15 to 0.57), nuclei shape (shape index 0.75 to 0.99) and focal adhesion cluster length (8-15 micrometer). To further investigate single cell-ECM biophysical interactions, nanofiber nets fused in crisscross patterns were manufactured to measure the "inside out" contractile forces of single mesenchymal stem cells (MSCs). The contractile forces (18-320 nano Newton) were found to scale with fiber structural stiffness (2 -100 nano Newton/micrometer). Cells were observed to shed debris on fibers, which were found to exert forces (15-20 nano Newton). Upon CO? deprivation, cells were observed to monotonically reduce cell spread area and contractile forces. During the apoptotic process, cells exerted both expansive and contractile forces. The platform developed in this study allows a wide parametric investigation of biophysical cues which influence cell behaviors with implications in tissue engineering, developmental biology, and disease biology.
Master of Science
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Nichols, Anne Elizabeth Carmack. "Scleraxis-mediated regulation of tendon and ligament cell mechanobiology." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/86631.

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Tendon and ligament injuries are common orthopedic problems that have an enormous impact on the quality of life of affected patients. Despite the frequency at which these injuries occur, current treatments are unable to restore native function to the damaged tissue. Because of this, reinjury is common. It is well known that mechanical stimulation is beneficial for promoting tendon and ligament development and tissue homeostasis; however, the specific mechanisms remain unclear. The transcription factor scleraxis (Scx) is an interesting candidate for mediating the tendon and ligament mechanoresponse, as it has been shown that Scx expression is induced by cyclic mechanical strain in tenocytes and is required for mechanically-induced stem cell tenogenesis. Moreover, Scx expression is increased in adult tendons following exercise. The studies described in this dissertation therefore focus on the combined role of Scx and mechanical stimulation in two contexts: 1) influencing ligament cell differentiation and 2) regulating adult tenocyte behavior. In the first study, transient Scx overexpression combined with mechanical strain in a 3D collagen hydrogel model was investigated as a means of deriving mature ligament cells from stem cells for use in ligament tissue engineering. Scx overexpression in C3H10T1/2 cells cultured in collagen hydrogels under static strain resulted in increased construct contraction and cell elongation, but no concurrent increase in the expression of ligament-related genes or production of glycosaminoglycans (GAG). When combined with low levels of cyclic strain, Scx overexpression resulted in increased mechanical properties of the tissue constructs, increased GAG production, and increased expression of ligament-related genes compared to cyclic strain alone. Together, these results demonstrate that Scx overexpression combined with cyclic strain can induce ligament cell differentiation and suggest that Scx does so by improving the mechanosensitivity of cells to cyclic strain. In the second study, the role of Scx in adult tenocyte mechanotransduction was explored using RNA-sequencing (RNA-seq) and small interfering RNA (siRNA) technologies. Equine tenocytes were exposed to siRNA targeting Scx or a control siRNA and maintained under cyclic mechanical strain prior to being submitted for RNA-seq. Comparison of the resulting transcriptomes revealed that Scx knockdown decreased the expression of several genes encoding important focal adhesion adaptor proteins. Correspondingly, Scx-depleted tenocytes showed abnormally long focal adhesions, decreased cytoskeletal stiffness, and an impaired ability to migrate on soft surfaces. This suggests that Scx regulates the tenocyte mechanoresponse by promoting the expression of focal adhesion-related genes. Combined, the results of these studies support a role for Scx in tendon and ligament cell mechanotransduction and identify the regulation of genes related to maintaining the cell-extracellular matrix connection and cytoskeletal dynamics as a potential mechanism. These findings enhance our understanding of how mechanical stimulation influences cell behavior and provide new research directions and methodologies for future studies of tendon and ligament mechanobiology.
Ph. D.
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Kamble, Harshad. "Design and Development of Cell Stretching Platforms for Mechanobiology Studies." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370968.

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Cells within the human body are continuously exposed to various mechanical stimuli due to organ function, movement and growth. Cellular response to such mechanical stimuli is known as a mechanobiological signalling, which is an integral part of the cell homeostasis. It is widely accepted that maladaptation of mechanobiological signalling may lead to dysfunction and/or disease. Thus, better understanding of mechanobiological signalling has become a key area of interest for researchers in the field of regenerative medicine and tissue engineering. However, complexity involved in the in vivo biological systems has been a major hurdle for comprehensive mechanobiological investigations. This technological gap motivates researchers to develop in vitro devices capable of introducing mechanical strain onto a cell culture and to closely mimic the in vivo physiological conditions. For example, various cell stretching approaches have been developed to induce mechanical strain onto a cell culture and trigger cellular responses such as migration, proliferation and orientation. However, very few existing cell stretching platforms fulfil the major requirement of a robust cell stretching tool such as high experimental throughput, well-characterised and controllable strain pattern, ease of operation, compatible with a wide range of imaging systems and most importantly high biological relevance for systematic mechanobiological investigation. Thus, the present thesis focuses on the development of robust cell stretching platforms based on electromagnet and pneumatic actuations to address these existing limitations and subsequently to establish a systematic approach for in-depth mechanobiological investigation. To provide a systematic approach for detailed study, the first necessary step is quantification of the parameter. Thus, in the Chapter three of this thesis, a novel cell stretching platform based on a single sided uniaxial stretching approach was developed to apply tensile strain onto the cell culture and observe cellular response of the cells towards different strains in the same field of view with lower fabrication and operation complexity. The effectiveness of the platform was demonstrated by observing the response of cells in culture under different strain amplitudes. In the Chapter four, a standardised numerical tool was developed for the singlesided uniaxial cell stretching platform. The numerical tool provided guidelines for the optimization parameters and paved way for the development of a double-sided cell stretching platform described in Chapter five. The developed platform was capable of investigating the cellular behaviour for a wide range of homogenous strain amplitudes with cyclic and static stretching conditions. Although the developed electromagnetically cell stretching platforms provided a standardised tool for systematic mechanobiological investigation, the biological relevance could still be improved. Thus, the Chapter six involved the development of a novel pneumatically actuated array-based cell stretching platform, which concurrently induced a range of cyclic strain onto the cell culture. It was developed to achieve cell patterns, which provided an improved biological relevance for mechanobiological studies. The toroidal shaped strain pattern was utilised to achieve circumferential cellular alignment of cells similar to that of in vivo smooth muscle in the vascular wall. Furthermore, the dimensions of the platform followed those of standard 96 well plates. This simple and effective design approach ensured a high compatibility with pre-clinical tools and protocols, which is critical for highthroughput cell-stretching assays. Collectively, the findings for these chapters and the thesis at large, suggest the high clinical compatibility and biological relevance of the cell stretching devices reported in this thesis provide promising platform for systematic mechanobiological investigations.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
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Balachandran, Kartik. "Aortic valve mechanobiology - the effect of cyclic stretch." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39486.

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Aortic valve disease is among the third most common cardiovascular disease worldwide, and is also a strong predictor for other cardiac related deaths. Altered mechanical forces are believed to cause changes in aortic valve biosynthetic activity, eventually leading to valve disease, however little is known about the cellular and molecular events involved in these processes. To gain a fundamental understanding into aortic valve disease mechanobiology, an ex vivo experimental model was used to study the effects of normal and elevated cyclic stretch on aortic valve remodeling and degenerative disease. The hypothesis of this proposal was that elevated cyclic stretch will result in increased expression of markers related to degenerative valve disease. Three aspects of aortic valve disease were studied: (i) Altered extracellular matrix remodeling; (ii) Aortic Valve Calcification; and (iii) Serotonin-induced valvulopathy. Results showed that elevated stretch resulted in increased matrix remodeling and calcification via a bone morphogenic protein-dependent pathway. In addition, elevated stretch and serotonin resulted in increased collagen biosynthesis and tissue stiffness via a serotonin-2A receptor-mediated pathway. This work adds to current knowledge on aortic valve disease mechanisms, and could pave the way for the development of novel treatments for valve disease and for the design of tissue engineered valve constructs.
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Mahajan, Gautam. "MECHANOBIOLOGY OF BRAIN-DERIVED CELLS DURING DEVELOPMENTAL STAGES." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1578332547849308.

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McBride, Sarah Howe. "MULTISCALE MECHANOBIOLOGY OF PERIOSTEAL BONE GENERATION: CELL SCALE STUDIES TO TRANSLATIONAL MODELS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1291048293.

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Sharma, Puja. "A Suspended Fiber Network Platform for the Investigation of Single and Collective Cell Behavior." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/82709.

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Cells interact with their immediate fibrous extracellular matrix (ECM); alignment of which has been shown influence metastasis. Specifically, intra-vital imaging studies on cell invasion from tumor-matrix interface and wounds along aligned fibers describe invasion to occur as singular leader (tip) cells, or as collective mass of a few chain or multiple tip cells. Recapitulation of these behaviors in vitro promises to provide new insights in how, when and where cells get the stimulus to break cell-cell junctions and ensue invasion by migrating along aligned tracks. Using Spinneret based Tunable Engineered Parameters (STEP) technique, we fabricated precise layout of suspended fibers of varying diameters (300, 500 and 1000 nm) mimicking ECM dimensions, which were interfaced with cell monolayers to study invasion. We demonstrated that nanofiber diameter and their spacing were key determinants in cells to invade either as singularly, chains of few cells or multiple-chains collectively. Through time-lapse microscopy, we reported that singular cells exhibited a peculiar invasive behavior of recoiling analogous to release of a stretched rubber band; detachment speed of which was influenced with fiber diameter (250, 425 and 400 µm/hr on small, medium and large diameter fibers respectively). We found that cells initiated invasion by putting protrusion on fibers; dynamics of which we captured using a contrasting network of mismatched diameters deposited orthogonally. We found that vimentin, a key intermediate filament upregulated in cancer invasion localized within a protrusion only when the protrusion had widened at the base, signifying maturation. To develop a comprehensive picture of invasion, we also developed strategies to quantify migratory speeds and the forces exerted by cells on fibers. Finally, we extended our findings of cell invasion to report a new wound healing assay to examine gap closure. We found that gaps spanned by crosshatch network of fibers closed faster than those on parallel fibers and importantly, we reported that gaps of 375 µm or larger did not close over a 45-day period. In summary, the methods and novel findings detailed from this study can be extended to ask multiple sophisticated hypotheses in physiologically relevant phenomenon like wound healing, morphogenesis, and cancer metastasis.
Ph. D.
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Books on the topic "Cell mechanobiology"

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Wagoner Johnson, A., and Brendan A. C. Harley, eds. Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-8083-0.

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Johnson, A. Wagoner. Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Boston, MA: Springer Science+Business Media, LLC, 2011.

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Mechanobiology handbook. Boca Raton: Taylor & Francis, 2011.

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Hayden, Huang, and Kwon Ronald Y, eds. Introduction to cell mechanics and mechanobiology. New York: Garland Science, 2013.

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F, Stoltz J., and International Symposium on Mechanobiology of Cartilage and Chondrocyte (1st : 1999 : Sainte-Maxime, France), eds. Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2000.

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F, Stoltz J., ed. Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2006.

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Mechanobiology: Cartilage and chondrocyte. Amsterdam: IOS Press, 2008.

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Robinson, Samuel Thomas. Bone mechanobiology of modeling and remodeling and the effect of hematopoietic lineage cells. [New York, N.Y.?]: [publisher not identified], 2020.

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Johnson, A. Wagoner, and Brendan Harley. Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Springer, 2011.

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Johnson, A. Wagoner, and Brendan Harley. Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Springer, 2014.

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Book chapters on the topic "Cell mechanobiology"

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Marcotti, Stefania, and Gwendolen C. Reilly. "Sugar-Coating the Cell." In Mechanobiology, 43–60. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118966174.ch3.

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Evans, Nicholas D., and Camelia G. Tusan. "Extracellular Matrix Structure and Stem Cell Mechanosensing." In Mechanobiology, 1–21. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118966174.ch1.

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Gautrot, Julien E. "Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales." In Mechanobiology, 297–329. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118966174.ch19.

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Kim, Byumsu, and Lawrence J. Bonassar. "Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior." In Advances in Experimental Medicine and Biology, 31–44. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25588-5_2.

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AbstractInvestigating the mechanobiology of chondrocytes is challenging due to the complex micromechanical environment of cartilagetissue. The innate zonal differences and poroelastic properties of the tissue combined with its heterogeneous composition create spatial- and temporal-dependent cell behavior, which further complicates the investigation. Despite the numerous challenges, understanding the mechanobiology of chondrocytes is crucial for developing strategies for treating cartilage related diseases as chondrocytes are the only cell type within the tissue. The effort to understand chondrocyte behavior under various mechanical stimuli has been ongoing over the last 50 years. Early studies examined global biosynthetic behavior under unidirectional mechanical stimulus. With the technological development in high-speed confocal imaging techniques, recent studies have focused on investigating real-time individual and collective cell responses to multiple / combined modes of mechanical stimuli. Such efforts have led to tremendous advances in understanding the influence of local physical stimuli on chondrocyte behavior. In addition, we highlight the wide variety of experimental techniques, spanning from static to impact loading, and analysis techniques, from biochemical assays to machine learning, that have been utilized to study chondrocyte behavior. Finally, we review the progression of hypotheses about chondrocyte mechanobiology and provide a perspective on the future outlook of chondrocyte mechanobiology.
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DeSimone, Antonio. "Cell Motility and Locomotion by Shape Control." In The Mathematics of Mechanobiology, 1–41. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45197-4_1.

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Perthame, Benoît. "Models of Cell Motion and Tissue Growth." In The Mathematics of Mechanobiology, 43–80. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-45197-4_2.

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Rape, Andrew D., Wei-Hui Guo, and Yu-Li Wang. "Responses of Cells to Adhesion-Mediated Signals: A Universal Mechanism." In Mechanobiology of Cell-Cell and Cell-Matrix Interactions, 1–10. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-8083-0_1.

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Franck, Christian, and Stacey A. Maskarinec. "Quantifying Cell-Matrix Deformations in Three Dimensions." In Mechanobiology of Cell-Cell and Cell-Matrix Interactions, 211–32. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-8083-0_10.

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Taylor, Rebecca E., Vikram Mukundan, and Beth L. Pruitt. "Tools for Studying Biomechanical Interactions in Cells." In Mechanobiology of Cell-Cell and Cell-Matrix Interactions, 233–65. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-8083-0_11.

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De Volder, Ross, and Hyunjoon Kong. "Biomaterials for Studies in Cellular Mechanotransduction." In Mechanobiology of Cell-Cell and Cell-Matrix Interactions, 267–77. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-8083-0_12.

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Conference papers on the topic "Cell mechanobiology"

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Pruitt, Beth L. "MEMS for cell mechanobiology." In 2014 IEEE International Electron Devices Meeting (IEDM). IEEE, 2014. http://dx.doi.org/10.1109/iedm.2014.7047147.

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Naimark, Oleg. "DNA open complex dynamics in cell mechanobiology." In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON PHYSICAL MESOMECHANICS. MATERIALS WITH MULTILEVEL HIERARCHICAL STRUCTURE AND INTELLIGENT MANUFACTURING TECHNOLOGY. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0034276.

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Hepburn, Matt, Philip Wijesinghe, Luke Major, Lixin Chin, Nicholas Hugenberg, Dawei Song, Assad A. Oberai, Yu Suk Choi, and Brendan F. Kennedy. "Quantitative micro-elastography for cell mechanobiology (Conference Presentation)." In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, edited by Joseph A. Izatt and James G. Fujimoto. SPIE, 2019. http://dx.doi.org/10.1117/12.2511486.

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Kamm, R. D., A. K. McVittie, and M. Bathe. "On the Role of Continuum Models in Mechanobiology." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1916.

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Abstract Models of cellular and subcellular mechanics are essential in gaining an understanding of the link between forces applied to a cell and its biological response. Various approaches can be used to construct these models, but one that holds considerable promise is through the use of continuum solid and fluid mechanics, coupled when necessary with molecular dynamic simulations. Here we present a continuum mechanics model of the effects of normal stress applied to a layer of airway epithelial cells. The model predicts widely differing stress distributions associated with basolateral membrane deformation, intercellular flow, or mechanical forcing by other methods such as in the use of adherent beads. When coupled with experimental results obtained from cell culture, these simulations can help to identify the site and possibly the underlying mechanisms of mechanotransduction. We also present some hypotheses concerning the nature of mechanotransduction at the molecular scale.
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Chun-Ting Li, Chin-Hsiung Tsai, Pai-Chi Li, and Po-Ling Kuo. "3D cell mechanobiology study using shear wave elasticity imaging." In 2014 IEEE International Ultrasonics Symposium (IUS). IEEE, 2014. http://dx.doi.org/10.1109/ultsym.2014.0463.

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Jile, Huge, Tsubasa S. Matsui, and Shinji Deguchi. "A new engineering system for the study of cell mechanobiology." In 2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2016. http://dx.doi.org/10.1109/mhs.2016.7824161.

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Doll, J. C., and B. L. Pruitt. "MEMS FORCE PROBES FOR CELL MECHANOBIOLOGY AT THE MICROSECOND SCALE." In 2012 Solid-State, Actuators, and Microsystems Workshop. San Diego: Transducer Research Foundation, 2012. http://dx.doi.org/10.31438/trf.hh2012.44.

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Mowla, Alireza, Brendan F. Kennedy, Matt S. Hepburn, Jiayue Li, Yu Suk Choi, Samuel Maher, and Danielle Vahala. "Subcellular mechano-microscopy for mechanobiology of 3D cell spheroid cultures." In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, edited by Joseph A. Izatt and James G. Fujimoto. SPIE, 2023. http://dx.doi.org/10.1117/12.2647323.

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Campana, Kimberly A., Eric Y. Shin, Beverly Z. Waisner, and Sherry L. Voytik-Harbin. "3D Cell Shape and Cell Fate are Regulated by the Dynamic Micro-Mechanical Properties of the Cell-ECM Interface." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176626.

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Abstract:
Mechanobiology is an interdisciplinary field that focuses on predicting and understanding cellular responses to mechanical loads. The extracellular matrix (ECM) represents a macromolecular framework that naturally imparts structural support and spatial organization for resident cells. The ECM also participates in the communication and transfer of mechanical loads to cells, in part, via integrin attachment to the cytoskeleton (CSK). Recently, using a tissue model in which cells are embedded in a 3D collagen ECM, we have shown that fundamental cell behaviors, including morphology, proliferation, contractility, and ECM remodeling properties, can be modulated by varying 3D microstructural organization and mechanical properties of the surrounding collagen fibrils[1]. While these and other results demonstrate the critical role played by the ECM in regulating cell behavior, the mechanical-based mechanisms underlying these critical cell-ECM interactions have yet to be fully elucidated [2].
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"OPEN COMPLEX DYNAMICS IN CELL MECHANOBIOLOGY AND THE PROBLEM OF CANCER." In Fizicheskaya mezomekhanika. Materialy s mnogourovnevoy ierarkhicheski organizovannoy strukturoy i intellektual'nye proizvodstvennye tekhnologii. Tomsk State University, 2020. http://dx.doi.org/10.17223/9785946219242/21.

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