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Journal articles on the topic 'Cell based studies'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Palonko, R. I. "STUDIES OF MAGNESIUM AND PHOSPHORUS COMBINED MEDICATION BASED ON CASEIN." Biotechnologia Acta 14, no. 5 (October 2021): 56–62. http://dx.doi.org/10.15407/biotech14.05.056.

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Aim. The Department of Biochemistry and Physiology of Animals, named after Academician Guly NUBIP of Ukraine, developed magnesium and phosphorus combined medication based on casein. Our aim was to test its bioavailability based on the ability to be hydrolyzed by a mixture of pancreatic digestive enzymes trypsin and chymotrypsin, also check the absence of cytotoxic effects on cell cultures. Methods. To assess bioavailability, we used hydrolysis of the medication with a mixture of trypsin and chymotrypsin, followed by detection of hydrolysis products by polyacrylamide gel electrophoresis. A standard MTT-test performed on both MT-4 and Namalva cell lines was used to assess cytotoxic effects. Results. Based on electrophoresis data, it was found that despite chemical modifications of the natural casein, the medication based on it is characterized by a high ability to hydrolyze by digestive enzymes under the same conditions as casein. Also, an MTT-test demonstrates that the medication has no cytotoxic properties against cell lines MT-4 and Namalva. Conclusions. Since the negative effects of the drug associated with its digestibility and toxicity have not been observed, it is recommended to continue the study of its effects on living organisms.

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2

Sun, Jing, Attila Tárnok, and Xuantao Su. "Deep Learning‐Based Single‐Cell Optical Image Studies." Cytometry Part A 97, no. 3 (January 25, 2020): 226–40. http://dx.doi.org/10.1002/cyto.a.23973.

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3

Stacey, Dennis W., and Masahiro Hitomi. "Cell cycle studies based upon quantitative image analysis." Cytometry Part A 73A, no. 4 (2008): 270–78. http://dx.doi.org/10.1002/cyto.a.20511.

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4

Zhou, Wei, Erek D. Nelson, Anan A. Abu Rmilah, Bruce P. Amiot, and Scott L. Nyberg. "Stem Cell-Related Studies and Stem Cell-Based Therapies in Liver Diseases." Cell Transplantation 28, no. 9-10 (June 26, 2019): 1116–22. http://dx.doi.org/10.1177/0963689719859262.

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Owing to the increasing worldwide burden of liver diseases, the crucial need for safe and effective interventions for treating end-stage liver failure has been a very productive line of inquiry in the discipline of hepatology for many years. Liver transplantation is recognized as the most effective treatment for end-stage liver disease; however, the shortage of donor organs, high medical costs, and lifelong use of immunosuppressive agents represent major drawbacks and demand exploration for alternative treatments. Stem cell-based therapies have been widely studied in the field of liver diseases and are considered to be among the most promising therapies. Herein, we review recent advances in the application of stem cell-related therapies in liver disease with the aim of providing readers with relevant knowledge in this field and inspiration to spur further inquiry.

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Simioni, A. R., O. P. Martins, Z. G. M. Lacava, R. B. Azevedo, E. C. D. Lima, B. M. Lacava, P. C. Morais, and A. C. Tedesco. "Cell Toxicity Studies of Albumin-Based Nanosized Magnetic Beads." Journal of Nanoscience and Nanotechnology 6, no. 8 (August 1, 2006): 2413–15. http://dx.doi.org/10.1166/jnn.2006.511.

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6

Xu, Xiao-Ning, and Gavin R. Screaton. "MHC/peptide tetramer-based studies of T cell function." Journal of Immunological Methods 268, no. 1 (October 2002): 21–28. http://dx.doi.org/10.1016/s0022-1759(02)00196-5.

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7

Harding, John, and Oleg Mirochnitchenko. "Preclinical Studies for Induced Pluripotent Stem Cell-based Therapeutics." Journal of Biological Chemistry 289, no. 8 (December 20, 2013): 4585–93. http://dx.doi.org/10.1074/jbc.r113.463737.

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8

Haddad, Mônica Santoro, Cristiane Valverde Wenceslau, Celine Pompeia, and Irina Kerkis. "Cell-based technologies for Huntington's disease." Dementia & Neuropsychologia 10, no. 4 (December 2016): 287–95. http://dx.doi.org/10.1590/s1980-5764-2016dn1004006.

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ABSTRACT Huntington's disease (HD) is a fatal genetic disorder, which causes the progressive breakdown of neurons in the human brain. HD deteriorates human physical and mental abilities over time and has no cure. Stem cell-based technologies are promising novel treatments, and in HD, they aim to replace lost neurons and/or to prevent neural cell death. Herein we discuss the use of human fetal tissue (hFT), neural stem cells (NSCs) of hFT origin or embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs), in clinical and pre-clinical studies. The in vivo use of mesenchymal stem cells (MSCs), which are derived from non-neural tissues, will also be discussed. All these studies prove the potential of stem cells for transplantation therapy in HD, demonstrating cell grafting and the ability to differentiate into mature neurons, resulting in behavioral improvements. We claim that there are still many problems to overcome before these technologies become available for HD patient treatment, such as: a) safety regarding the use of NSCs and pluripotent stem cells, which are potentially teratogenic; b) safety regarding the transplantation procedure itself, which represents a risk and needs to be better studied; and finally c) technical and ethical issues regarding cells of fetal and embryonic origin.

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9

Rodriguez, Antonio, and Erik K. Flemington. "Transfection-Mediated Cell-Cycle Signaling: Considerations for Transient Transfection-Based Cell-Cycle Studies." Analytical Biochemistry 272, no. 2 (August 1999): 171–81. http://dx.doi.org/10.1006/abio.1999.4156.

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10

Jin, Meiling, Yuansheng Xie, Qinggang Li, and Xiangmei Chen. "Stem Cell-Based Cell Therapy for Glomerulonephritis." BioMed Research International 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/124730.

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Glomerulonephritis (GN), characterized by immune-mediated inflammatory changes in the glomerular, is a common cause of end stage renal disease. Therapeutic options for glomerulonephritis applicable to all cases mainly include symptomatic treatment and strategies to delay progression. In the attempt to yield innovative interventions fostering the limited capability of regeneration of renal tissue after injury and the uncontrolled pathological process by current treatments, stem cell-based therapy has emerged as novel therapy for its ability to inhibit inflammation and promote regeneration. Many basic and clinical studies have been performed that support the ability of various stem cell populations to ameliorate glomerular injury and improve renal function. However, there is a long way before putting stem cell-based therapy into clinical practice. In the present article, we aim to review works performed with respect to the use of stem cell of different origins in GN, and to discuss the potential mechanism of therapeutic effect and the challenges for clinical application of stem cells.

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11

Goshtasbi, Alireza, Hao Wang, Zeng Qiu, and Daniel Wilkosz. "Model-Based Membrane Hydration Studies for Automotive Fuel Cell Systems." ECS Meeting Abstracts MA2021-02, no. 37 (October 19, 2021): 1103. http://dx.doi.org/10.1149/ma2021-02371103mtgabs.

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12

Chen, Gang, Hongguang Xia, Yu Cai, Dawei Ma, Junying Yuan, and Chengye Yuan. "Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies." MedChemComm 2, no. 4 (2011): 315. http://dx.doi.org/10.1039/c0md00236d.

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13

Cooley, Christina B., Brian M. Trantow, Fredrik Nederberg, Matthew K. Kiesewetter, James L. Hedrick, Robert M. Waymouth, and Paul A. Wender. "Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies." Journal of the American Chemical Society 131, no. 45 (November 18, 2009): 16401–3. http://dx.doi.org/10.1021/ja907363k.

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14

Marikkannu, K. R., K. Surya Kala, G. Paruthimal Kalaignan, and T. Vasudevan. "Electroplating of nickel from acetate based bath – Hull Cell studies." Transactions of the IMF 86, no. 3 (May 2008): 172–76. http://dx.doi.org/10.1179/174591908x304153.

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15

Lal, Sweta, Vinod M. Janardhanan, Melepurath Deepa, and Kirti Chandra Sahu. "Experimental and Modeling Studies of Paper Based Methanol Fuel Cell." ECS Transactions 80, no. 10 (October 25, 2017): 843–49. http://dx.doi.org/10.1149/08010.0843ecst.

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16

Fruhauf, Sebastian, Heidi Schwartz, Franz Ottner, Rudolf Krska, and Elisavet Vekiru. "Yeast cell based feed additives: studies on aflatoxin B1and zearalenone." Food Additives & Contaminants: Part A 29, no. 2 (February 2012): 217–31. http://dx.doi.org/10.1080/19440049.2011.630679.

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17

Letasiova, Silvia, Amy Hunter, Maureen Spratt, Alex Armento, Mitchell Klausner, and Seyoum Ayehunie. "Human dendritic cell based model (DC-100) for immunotoxicity studies." Toxicology Letters 211 (June 2012): S138. http://dx.doi.org/10.1016/j.toxlet.2012.03.504.

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18

Sampedro, Angel, Ruth Villalonga-Planells, Manuel Vega, Guillem Ramis, Silvia Fernández de Mattos, Priam Villalonga, Antoni Costa, and Carmen Rotger. "Cell Uptake and Localization Studies of Squaramide Based Fluorescent Probes." Bioconjugate Chemistry 25, no. 8 (July 24, 2014): 1537–46. http://dx.doi.org/10.1021/bc500258b.

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19

Shu, Yiwei, Ho Nam Chan, Dongshi Guan, Hongkai Wu, and Lan Ma. "A simple fabricated thickness-based stiffness gradient for cell studies." Science Bulletin 62, no. 3 (February 2017): 222–28. http://dx.doi.org/10.1016/j.scib.2016.12.012.

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20

Guillén, C., M. A. Martı́nez, J. Herrero, and M. T. Gutiérrez. "Chemical studies of solar cell structures based on electrodeposited CuInSe2." Solar Energy Materials and Solar Cells 58, no. 2 (June 1999): 219–24. http://dx.doi.org/10.1016/s0927-0248(98)00205-0.

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21

Prasad, Chakka Vara, Vadithe Lakshma Nayak, Sistla Ramakrishna, and Uppuluri Venkata Mallavadhani. "Novel menadione hybrids: Synthesis, anticancer activity, and cell-based studies." Chemical Biology & Drug Design 91, no. 1 (August 21, 2017): 220–33. http://dx.doi.org/10.1111/cbdd.13073.

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22

Tessier, Laurent, Ana Lacoste, Henri Doyeux, Serge Salavin, Jiting Ouyang, Thierry Callegari, Nicolas Lebarq, Bruno Caillier, and Jean-Pierre Boeuf. "Improvement of PDP discharge efficiency based on macro-cell studies." Journal of the Society for Information Display 11, no. 3 (2003): 551. http://dx.doi.org/10.1889/1.1825685.

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23

Domaszewska-Szostek, Anna, Marta Krzyżanowska, and Maria Siemionow. "Cell-Based Therapies for Chronic Wounds Tested in Clinical Studies." Annals of Plastic Surgery 83, no. 6 (December 2019): e96-e109. http://dx.doi.org/10.1097/sap.0000000000001947.

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Varela, Juan A., Christoffer Åberg, Jeremy C. Simpson, and Kenneth A. Dawson. "Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies." Small 11, no. 17 (December 15, 2014): 2026–31. http://dx.doi.org/10.1002/smll.201401849.

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25

Madhu, Basetti, Madalina Dadulescu, and John Griffiths. "Artefacts in 1H NMR-based metabolomic studies on cell cultures." Magnetic Resonance Materials in Physics, Biology and Medicine 28, no. 2 (August 10, 2014): 161–71. http://dx.doi.org/10.1007/s10334-014-0458-z.

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26

Park, You Jeong, Kuniyasu Niizuma, Maxim Mokin, Mari Dezawa, and Cesar V. Borlongan. "Cell-Based Therapy for Stroke." Stroke 51, no. 9 (September 2020): 2854–62. http://dx.doi.org/10.1161/strokeaha.120.030618.

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Stem cell-based regenerative therapies may rescue the central nervous system following ischemic stroke. Mesenchymal stem cells exhibit promising regenerative capacity in in vitro studies but display little to no incorporation in host tissue after transplantation in in vivo models of stroke. Despite these limitations, clinical trials using mesenchymal stem cells have produced some functional benefits ascribed to their ability to modulate the host’s inflammatory response coupled with their robust safety profile. Regeneration of ischemic brain tissue using stem cells, however, remains elusive in humans. Multilineage-differentiating stress-enduring (Muse) cells are a distinct subset of mesenchymal stem cells found sporadically in connective tissue of nearly every organ. Since their discovery in 2010, these endogenous reparative stem cells have been investigated for their therapeutic potential against a variety of diseases, including acute myocardial infarction, stroke, chronic kidney disease, and liver disease. Preclinical studies have exemplified Muse cells’ unique ability mobilize, differentiate, and engraft into damaged host tissue. Intravenously transplanted Muse cells in mouse lacunar stroke models afforded functional recovery and long-term engraftment into the host neural network. This mini-review article highlights these biological properties that make Muse cells an exceptional candidate donor source for cell therapy in ischemic stroke. Elucidating the mechanism behind the therapeutic potential of Muse cells will undoubtedly help optimize stem cell therapy for stroke and advance the field of regenerative medicine.

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Mumm, Florian, Kai M. Beckwith, Sara Bonde, Karen L. Martinez, and Pawel Sikorski. "A Transparent Nanowire-Based Cell Impalement Device Suitable for Detailed Cell-Nanowire Interaction Studies." Small 9, no. 2 (October 4, 2012): 263–72. http://dx.doi.org/10.1002/smll.201201314.

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28

Kocherova, Ievgeniia, Bartosz Kempisty, Greg Hutchings, Lisa Moncrieff, Claudia Dompe, Krzysztof Janowicz, Jim Petitte, Jamil A. Shibli, and Paul Mozdziak. "Cell-based approaches in drug development – a concise review." Medical Journal of Cell Biology 8, no. 1 (April 29, 2020): 44–49. http://dx.doi.org/10.2478/acb-2020-0005.

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AbstractIn vitro models represent an alternative technique to in vivo or ex vivo studies in the drug development process. Cell-based assays are used to measure the level of proliferation and toxicity, as well as activation of signalling pathways and changes in morphology in cultivated cells. The studies conducted in vitro are aimed to estimate the newly synthesised drugs’ ability to permeate biological barriers and exert their therapeutic or cytotoxic effects. However, more than half of all studied drugs fail in the second or third phase of clinical trials due to a lack of confirmed efficacy. About a third of drugs fail because of safety issues, such as unacceptable levels of toxicity. To reduce attrition level in drug development, it is crucial to consider the implementation of translational phenotypic assays as well as to decipher various molecular mechanisms of action for new molecular entities. In this review, we summarise the existing cell-based methods most frequently used in the studies on drugs, taking into account their advantages and drawbacks.Running title: Cell-based approaches in drug development

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29

Linkova, Daria D., Yulia P. Rubtsova, and Marfa N. Egorikhina. "Cryostorage of Mesenchymal Stem Cells and Biomedical Cell-Based Products." Cells 11, no. 17 (August 29, 2022): 2691. http://dx.doi.org/10.3390/cells11172691.

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Mesenchymal stem cells (MSCs) manifest vast opportunities for clinical use due both to their ability for self-renewal and for effecting paracrine therapeutic benefits. At the same time, difficulties with non-recurrent generation of large numbers of cells due to the necessity for long-term MSC expansion ex vivo, or the requirement for repeated sampling of biological material from a patient significantly limits the current use of MSCs in clinical practice. One solution to these problems entails the creation of a biobank using cell cryopreservation technology. This review is aimed at analyzing and classifying literature data related to the development of protocols for the cryopreservation of various types of MSCs and tissue-engineered structures. The materials in the review show that the existing techniques and protocols for MSC cryopreservation are very diverse, which significantly complicates standardization of the entire process. Here, the selection of cryoprotectors and of cryoprotective media shows the greatest variability. Currently, it is the cryopreservation of cell suspensions that has been studied most extensively, whereas there are very few studies in the literature on the freezing of intact tissues or of tissue-engineered structures. However, even now it is possible to develop general recommendations to optimize the cryopreservation process, making it less traumatic for cells.

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30

Bai, Xiaowen. "Stem Cell-Based Disease Modeling and Cell Therapy." Cells 9, no. 10 (September 29, 2020): 2193. http://dx.doi.org/10.3390/cells9102193.

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Stem cell science is among the fastest moving fields in biology, with many highly promising directions for translatability. To centralize and contextualize some of the latest developments, this Special Issue presents state-of-the-art research of adult stem cells, induced pluripotent stem cells (iPSCs), and embryonic stem cells as well as cancer stem cells. The studies we include describe efficient differentiation protocols of generation of chondrocytes, adipocytes, and neurons, maturation of iPSC-derived cardiomyocytes and neurons, dynamic characterization of iPSC-derived 3D cerebral organoids, CRISPR/Cas9 genome editing, and non-viral minicircle vector-based gene modification of stem cells. Different applications of stem cells in disease modeling are described as well. This volume also highlights the most recent developments and applications of stem cells in basic science research and disease treatments.

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31

Ramos, Geraldo A., and Joshua M. Hare. "Cardiac Cell-Based Therapy: Cell Types and Mechanisms of Actions." Cell Transplantation 16, no. 9 (October 2007): 951–61. http://dx.doi.org/10.3727/096368907783338208.

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Over the past decade, the concept that the heart could undergo cardiac regeneration has rapidly evolved. Studies have indicated that numerous sites in the body harbor stem or progenitor cells, prompting clinical trials of these potential therapeutic cell-based approaches. Most notable are the series of trials utilizing either skeletal myoblasts or autologous whole bone marrow. More recently the quest has focused on specific bone marrow constituents, most notably the mesenchymal stem cell, which has several unique advantages including immunoprivilege, immunosuppression, and the ability to home to areas of tissue injury. Most recently, cells have been identified within the heart itself that are capable of self-replication and differentiation. The discovery of cardiac stem cells offers not only a potential therapeutic approach but also provides a plausible target for endogenous activation as a therapeutic strategy. Together the new insights obtained from studies of cell-based cardiac therapy have ushered in new biological paradigms and enormous potential for novel therapeutic strategies for cardiac disease.

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32

Rigaud, Vagner O. C., Robert Hoy, Sadia Mohsin, and Mohsin Khan. "Stem Cell Metabolism: Powering Cell-Based Therapeutics." Cells 9, no. 11 (November 16, 2020): 2490. http://dx.doi.org/10.3390/cells9112490.

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Cell-based therapeutics for cardiac repair have been extensively used during the last decade. Preclinical studies have demonstrated the effectiveness of adoptively transferred stem cells for enhancement of cardiac function. Nevertheless, several cell-based clinical trials have provided largely underwhelming outcomes. A major limitation is the lack of survival in the harsh cardiac milieu as only less than 1% donated cells survive. Recent efforts have focused on enhancing cell-based therapeutics and understanding the biology of stem cells and their response to environmental changes. Stem cell metabolism has recently emerged as a critical determinant of cellular processes and is uniquely adapted to support proliferation, stemness, and commitment. Metabolic signaling pathways are remarkably sensitive to different environmental signals with a profound effect on cell survival after adoptive transfer. Stem cells mainly generate energy through glycolysis while maintaining low oxidative phosphorylation (OxPhos), providing metabolites for biosynthesis of macromolecules. During commitment, there is a shift in cellular metabolism, which alters cell function. Reprogramming stem cell metabolism may represent an attractive strategy to enhance stem cell therapy for cardiac repair. This review summarizes the current literature on how metabolism drives stem cell function and how this knowledge can be applied to improve cell-based therapeutics for cardiac repair.

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33

Joseph George Kallivayalil, Kavitha S, Vishnupriya V, and Gayathri R. "Engineered Cell Based Therapeutics." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 17, 2020): 780–85. http://dx.doi.org/10.26452/ijrps.v11ispl3.3019.

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Engineered cell-based therapeutics is having a great commitment in the field of treatment of human diseases. Scientific studies revealed that cell-based therapeutics play a key role in the treatment of cancers which can be an alternative for traditional immunotherapy. Even though there have been promising results, and the potential side effects resulting in mortality forced the scientists to impart regulations in the current therapies. These are evident in the growing frame of the literature of synthetic biology. Synthetic Biology empowered these new approaches to several applications in the medical field, including the development of bioengineered cell-based immunotherapies, peculiarly T-cell engineering with tumour-targeting receptors and the Chimeric Antigen Receptor (CAR)-T cells. The specific applications of this bioengineering of cells include direct injection of cells, merging the cells with a biomaterial scaffold in an in vitro or situ condition, or the biomaterial scaffold implantation alone which can induce surrounding cells leading to tissue restoration. Hence the aim of this review article is to highlight the various aspects of engineered cell-based therapeutics.

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Kim, Hi Chul, Jin Yeong Heo, Tae-Kyu Lee, Ssang-Goo Cho, and Yong-Jun Kwon. "Optimization of Cell-Based cDNA Microarray Conditions for Gene Functional Studies in HEK293 Cells." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 8 (March 21, 2017): 1053–59. http://dx.doi.org/10.1177/2472555217699823.

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Since the cell-based cDNA microarray (CBCM) technique has been a useful tool for gain-of-function studies, many investigators have used CBCMs to identify interesting genes. However, this method requires better-established conditions to ensure high reverse transfection efficiency without cross-contamination. Therefore, we optimized CBCM techniques through various means. We determined that Lipofectamine 2000 was the most appropriate transfection reagent by evaluating eight commercialized reagents, and we determined that the most effective concentrations for printing solution constituents were 0.2 M sucrose (to yield a final concentration of 32 mM) and 0.2% gelatin (to yield a final concentration 0.075%). After examining various combinations, we also determined that the best concentrations of cDNA and transfection reagent for optimal reverse transfection efficiency were 1.5 µg/5 µL of cDNA and 5.5 µL of Lipofectamine 2000. Finally, via a time course, we determined that 72 h was the most effective reaction duration for reverse transfection, and we confirmed the stability of cDNA spot activity of CBCMs for various storage periods. In summary, the CBCM conditions that we have identified can provide more effective outcomes for cDNA reverse transfection on microarrays.

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Kim, Hi Chul, David Shum, Hyang Sook Seol, Se Jin Jang, Ssang-Goo Cho, and Yong-Jun Kwon. "Development of Cell-Defined Lentivirus-Based Microarray for Mammalian Cells." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 1 (October 5, 2016): 108–13. http://dx.doi.org/10.1177/1087057116672417.

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Although reverse transfection cell microarray (RTCM) is a powerful tool for mammalian cell studies, the technique is not appropriate for cells that are difficult to transfect. The lentivirus-infected cell microarray (LICM) technique was designed to improve overall efficiency. However, LICM presents new challenges because individual lentiviral particles can spread through the cell population, leading to cross-contamination. Therefore, we designed a cell-defined lentivirus microarray (CDLM) technique using cell-friendly biomaterials that are controlled by cell attachment timing. We selected poly-l-lysine (PLL) with Matrigel as the best combination of biomaterials for cell-defined culture. We used 2 µL PLL to determine by titration the optimum concentration required (0.04% stock, 0.005% final concentration). We also determined the optimum concentration of 10 µL of lentivirus particles for maximum reverse infection efficiency (1 × 108 infectious units [IFU]/mL stock, 62.5% final concentration) and established the best combination of components for the lentivirus mixture (10 µL of lentivirus particles and 2 µL each of siGLO Red dye, Matrigel, and 0.04% PLL). Finally, we validated both the effect of reverse infection in various cell lines and lentivirus spot activity in CDLM by storage period. This method provides an effective lentivirus-infected cell microarray for large-scale gene function studies.

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Campos de Carvalho, Antonio Carlos, and Adriana Bastos Carvalho. "Stem Cell-Based Therapies in Chagasic Cardiomyopathy." BioMed Research International 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/436314.

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Chagas disease is caused byTrypanosoma cruziand can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.

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37

Price, Leo, Bob van de Water, Joost van Delft, Jan Commandeur, Michiel Braver, Maarten Coonen, Sreenivasa Ramaiahgari, Danyel Jennen, and John Meerman. "A physiologically relevant HepG2 cell based 3D cell culture model for high throughput toxicity studies." Toxicology Letters 221 (August 2013): S138. http://dx.doi.org/10.1016/j.toxlet.2013.05.269.

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38

Faghfuri, Elnaz, Mahdi Abdoli Shadbad, Amir Hossein Faghfouri, and Narges Soozangar. "Cellular immunotherapy in gastric cancer: adoptive cell therapy and dendritic cell-based vaccination." Immunotherapy 14, no. 6 (April 2022): 475–88. http://dx.doi.org/10.2217/imt-2021-0285.

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Gastric cancer (GC) is one of the most frequently diagnosed malignancies. Recent studies have highlighted cellular immunotherapy (CI) as a promising approach for treating this disease. Among the CI-based approaches, adoptive cell therapy and dendritic cell-based vaccination are commonly studied in preclinical and clinical trials. Here we review the current evidence on the potentiality of CI in treating GC, the targets for adoptive cell therapy, ongoing clinical trials, constraints and the future outlook. The results suggest that there is a need to identify novel biomarkers that predict which GC patients will most likely respond to these approaches. Also, CI plus chemotherapy or immune checkpoint inhibitors can improve the survival of patients with late-stage GC. Therefore, this approach can be promising for treating these patients.

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Ali, K., and M. Abdel-Mottaleb. "Photochemical Studies and Dye Sensitized Solar Cell Based On 8-Hydroxyquinoline." International Conference on Chemical and Environmental Engineering 7, no. 7 (May 1, 2014): 1–9. http://dx.doi.org/10.21608/iccee.2014.35402.

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40

McIntosh, Andrew, Yi Lu, and Nathan Skene. "CELL- AND TISSUE-TYPE ENRICHMENT TESTING BASED ON GENETIC ASSOCIATION STUDIES." European Neuropsychopharmacology 63 (October 2022): e35. http://dx.doi.org/10.1016/j.euroneuro.2022.07.075.

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41

Lim, Megan S., and Kojo S. J. Elenitoba-Johnson. "Mass Spectrometry-based Proteomic Studies of Human Anaplastic Large Cell Lymphoma." Molecular & Cellular Proteomics 5, no. 10 (June 19, 2006): 1787–98. http://dx.doi.org/10.1074/mcp.r600005-mcp200.

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42

Baxter, Gregory T. "Hurel™ — anIn Vivo-surrogate Assay Platform for Cell-based Studies." Alternatives to Laboratory Animals 37, no. 1_suppl (September 2009): 11–18. http://dx.doi.org/10.1177/026119290903701s01.

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Vardar, E., Michel Vert, Jean Coudane, V. Hasirci, and N. Hasirci. "Porous Agarose-Based Semi-IPN Hydrogels: Characterization and Cell Affinity Studies." Journal of Biomaterials Science, Polymer Edition 23, no. 18 (May 11, 2012): 2273–86. http://dx.doi.org/10.1163/156856211x614770.

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RAGDE, HAAKON, WILLIAM A. CAVANAGH, and BENJAMIN A. TJOA. "DENDRITIC CELL BASED VACCINES: PROGRESS IN IMMUNOTHERAPY STUDIES FOR PROSTATE CANCER." Journal of Urology 172, no. 6 Part 2 (December 2004): 2532–38. http://dx.doi.org/10.1097/01.ju.0000144211.51111.e4.

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Pluchino, Stefano, Roberto Furlan, and Gianvito Martino. "Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies." Current Opinion in Neurology 17, no. 3 (June 2004): 247–55. http://dx.doi.org/10.1097/00019052-200406000-00003.

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Vesela, Eva, Katarina Chroma, Zsofia Turi, and Martin Mistrik. "Common Chemical Inductors of Replication Stress: Focus on Cell‐Based Studies." Biomolecules 7, no. 4 (February 21, 2017): 19. http://dx.doi.org/10.3390/biom7010019.

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Chuck, Roy S., Ashley Behrens, and Peter J. McDonnell. "Microkeratome-based limbal harvester for limbal stem cell transplantation: preliminary studies." American Journal of Ophthalmology 131, no. 3 (March 2001): 377–78. http://dx.doi.org/10.1016/s0002-9394(00)00801-1.

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Pelled, Gadi, Kuangshin Tai, Dima Sheyn, Yoram Zilberman, Sangamesh Kumbar, Lakshmi S. Nair, Cato T. Laurencin, Dan Gazit, and Christine Ortiz. "Structural and nanoindentation studies of stem cell-based tissue-engineered bone." Journal of Biomechanics 40, no. 2 (January 2007): 399–411. http://dx.doi.org/10.1016/j.jbiomech.2005.12.012.

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Zhu, Yong Jian, Feng Jun Chen, and Shao Hui Yin. "Studies on Mega-Pixel Cell Phone Lenses Based on Aspheric Optics." Applied Mechanics and Materials 109 (October 2011): 441–44. http://dx.doi.org/10.4028/www.scientific.net/amm.109.441.

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Abstract:

According to the principle of optical design, two kinds of 2 Mega-pixel cell phone camera lenses are proposed. One is made up of three plastic (3P) lenses; the other is made up of two plastic lenses and one glass (2P1G) lens. The shapes of all lenses are aspheric. By comparison, the overall length of 2P1G lens is much less than that of 3P lens. Furthermore, in FOV the former is 5 degrees larger than the latter. At the same time, in distortion of the maximum field angle, the former is much less. The other aberrations of 2P1G lens are almost same to those of 3P lens. Therefore, in cell phone camera lens design, it’s recommended to adopt one aspheric glass lens to improve the performance and compactness though the cost will become a little higher due to the introduction of aspheric glass lens. However, the cost of aspheric glass lens could be reduced tremendously by a new cost-effective manufacturing method  compression molding technology.

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Novik, Eric, Timothy J. Maguire, Piyun Chao, K. C. Cheng, and Martin L. Yarmush. "A microfluidic hepatic coculture platform for cell-based drug metabolism studies." Biochemical Pharmacology 79, no. 7 (April 2010): 1036–44. http://dx.doi.org/10.1016/j.bcp.2009.11.010.

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